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Query: [S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEPDSVIEDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSESRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISRLast
1 -122.000[S] KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins  ali  100  1MEPDSVIEDKTIELMISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSESRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR 508
2 -63.500[D] KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats  ali follow..  15  392............................................................................................................................RADEVEALTFPPSSGKSFIMGADEALESE---LGPGELAGLTVANEADSLTYDIANNKDALRKTWNP----KFTLRSHFDGIRAL-AFHPIEPVLITASEDHTLKMWNLQKTEPIYTFRAHKGPVLCVVMNGEQCYSGGTDGLIQGWNTTNPNLRGPLLGHTDAVWGLAYSAAHLLSCSADGTLRLWNTTEVAPASVFNDIKELGIPASLVSSDPSHMVASFSKGYTSIFNMETQQRILTLENSSCQINRVISTLSISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVNGLYLMSGSHDCSIRLWNLE---------SKTCIQEFTAHEESIHDVAFSKCYIASAGADALAKVF......................... 779
3 -62.900[S] KOG0271 Notchless-like WD40 repeat-containing protein  ali follow..  17  46............................................................................................................................SDDPVPISFFTTEGAEIVDSIRRVRPVTRCSASIPGHGEPVISAQFSPDGRGLASGSGDQTMRIWDIELELLHTCKSHKSWVLCI-AWSPDATKIASACKNGEICIWNAKTGEQIKTLKRHKQWITSLAWTCRLLASCGKDGNIFIWDTVQGTVVRCLSGHTASVTCLRWGGEGIYSGSQDRTVKMWRADDGV---MCRNMTGHAHWINTLALDYALRTSCFEPSKRCIKPDTVEECQKVAQTRYEAA-LEIAGGERLVSGSDDFTLFMWNPETKQSINRMTGHMQLVNQVVFDTRYIASASFDKSVKLWCGR---------TGKYLASLRGHVGPVYQVAWDSRLLVSGSADSTLKVFELKTKSLYYDLPGHGDEVFTVDWS. 453
4 -62.800[S] KOG0295 WD40 repeat-containing protein  ali follow..  22  1............................................................................................................................................MSLSERQKEEINRAIAEYMQNNGYSESFSVFLKESSLSENDIKPLGGILEKKWTTLRLQRKVNDLESKL-QESQREINHGAPTRDKRQAADWIPRPPETQKLTGHRLPITRVIFLWTIMASCSEDATIKVWDYETGQLERTLKGHTDAVNDIAIDAAGLVSCSSDLSIKLWDFGQ--TYDCLKSLKGHEHTVSSVTFTGDFVLSASRDHTIKQWDISTGYCVYTFRGHNDWVRMIRIDGTLFASASLDQTVTVWSFATKSAKLVLRDHEHAVECVEWSTHILFSGSRDRSIKAWNIN---------TGDVLFTLLAHENWVRGLAFKGKYLISVADDKTLRVWELSAQRCMKAIEAHEHFVSTVAFH. 383
5 -62.600[K] KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA)  ali follow..  17  111...............................KDDHTDLHDFDVKNLKSLSLPSHVA--DRTAQQYRQNKYQLHFSRITFDLLLHFLFENVSNGGSIIIKLINQHIDIHIVPGRPTVLENAKVINEQEGITGQSFERGDAQLQPVKLQQMPMDKEMEKIVEMDLEEEDMMHQNDPNNQSPKLLKEFRKLHEPNAEDAPSRDYIPLPPHKGVDILSEVEAVKDWSKRLHLGPRASLPSVCMYTFHHTNNNMNCAEFDSTMIACGFQESYIRLWSIKDSDGSVRLLSHSGPVYGTTFSPDNLLSCSEDASARLWSVDTKTA---LVAYKGHTGPVWDVAFFGHYFATASHDQTAQLWSCDHIYPLRVFAGHLSDVDCVTFNSAYVLTGSSDKTCRLWDVHRGHSVRVFNGHTQPVTAVAIDGHTMASADSEGLIHLWDIG---------TGRRIKTMRGHRGNIYSLSFESTVLVSGGSDCTVRAWDVFKTNYNNPVSSSLTGSVVTPFS. 598
6 -61.900[A] KOG0285 Pleiotropic regulator 1  ali follow..  17  76............................................................................................................................APLKALALPGPKGSKELRKSATEKATLPPRDLNNTGNPGKSTAILPAPGSFSSTAALMERMPSRWPRPEWHYRVLQGHLGWVRSV-AFDPSNEWFCTGSADRTIKIWDVATGVLKLTLTGHIGQVRGLAVRHTYMFSAGDDKQVKCWDLEQNKVIRSYHGHLHGVYCLALHPTLVLTGGRDSVCRVWDIRTKMQIFVL----PHDSDVFSVLATDPQVITGSHDSTIKFWDLRYGKSMATITNHKKTVRAMALKENDFVSASADNIKKFSLPKGEFCHNMLSLQRDIINAVAVNEDVMVTGGDKGGLWFWDWKSGHNFQRA-ETIVQPGSLESEAGIYAACYTGSRLVTCEGDKTIKMWKEDED--------ATPETHPLNFK. 469
7 -61.600[R] KOG0286 G-protein beta subunit  ali follow..  18  2................................................................................................................................................................................................GEMEQLRQEAEQLKKQIADARKACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGVACGGLDNMCSIYNLKSRENVKVSRELSAHTGYLSCCRFDDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVDFNLFISGACDASAKLWDVREGTCRQTFTGHESDINAICFNGEAICTGSDDASCRLFDLRADQELICFSH-------ESIICGITSVAFSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVT. 321
8 -61.100[S] KOG0316 Conserved WD40 repeat-containing protein  ali follow..  18  1.........................................................................................................................................................................................MSATELPTKEAHILKGHEGAVLAA-RFNGDGNYALTCGKDRTIRLWNPHRGILIKTYKSHGREVRDVHVDNAKFCSCGGDRQVYYWDVSTGRVIRKFRGHDGEVNAVKFNDSSVVSAGFDRSLRVWDCRSHSVEPVQ-IIDTFLDTVMSVVLTKTEIIGGSVDGTVRTFDMRIGREMSDNLGQPVNCISISNDGNCVLAGCLDSTLRLLDRTTGELLQVYKGHISKSFKTDCSDAHVIGGSEDGLVFFWDLV---------DAKVLSKFRAHDL-VNSIDVDFYKFFVAGDKRELPPEGRLYVDFFGRWYNSIDFVIYVSNS. 335
9 -60.700[U] KOG0276 Vesicle coat complex COPI, beta` subunit  ali follow..  18  2....................................................................................................................................................PLRLEIKRKLAQRSERVKSVDLHPTEPWILASLYSGTLCIWNYQTQVAKSFEVTELPVRSA-KFVARKQWVVAGADDMYIRVYNYNTMDKVKVFEAHSDYIRCVAVTLPYVLSSSDDMLIKLWDWEKGACTQIFEGHSHYVMQVTFNPKDFASASLDRTIKIWNLGSPD---PNFTLDAHQKGVNCVDYDKPYLITGSDDHTAKVWDYQTKSCVQTLEGHTHNVSAVCFELPIIITGSEDGTVRIWHATTYRLENTLNYGLERVWAIGYSSRRVVIGYDEGTIMVKL----------GREIPVASMDNTGKIIWAKHNQTANIKSIGADYEVTDGERLPLS-VKELGTCDLYPQSLKHN. 362
10 -59.900[A] KOG0265 U5 snRNP-specific protein-like factor and related proteins  ali follow..  20  4...................................................................................................................................................KRPNNSVILAQEAKRSKNDLMAYTNRDKALLESGVRRTSNLQAP----IMQLEGHEGEIFTA-EFHPEGELLLSSGFDRQIYIWQVYEDENVMAMSGHSGAVMEAHFDGSHIFTCSTDKTLAFWDIATGQRQRRFKGHGNFVNSVQGSRRGLCSGSDDRTIKIWDARKKHAAHTL----ESPFQVTAVCFTGEQVISGGIDNEVKIWDIRKQAVLHHLRGHSDTITGMSLEGDFILTNAMDNTLRVWDVRGERCVKVFQGHEKNLLRCAWGSDKITSGSADRHVYIWDVN---------TRRILYKLPGHNGSVNAVDFKEPLILSGSSDKTLYLGEIDE..................... 347
11 -59.500[A] KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  16  215.........................................................................................................DQTMSIHETETQETLRVLPLYESIEGGAIGHNGNLFTVGEEFVIETAKLVRKKRIASSNLDHLAYDVVSNRFLAISAEQNLIILDFENLKARQIVGFHDEIYSCCLLGKDESHMAVASNTSEIRLYNTKTLDCQLIRGHTESVLSVVSPDTSLLASCSKDNSIIFWRLSTLVPVAAATGHANTVTALAISNTGLASVSTDCTIKLWGLGVSPKLTCSSTMVAHGKDVNCVDISDALIATGGMDKLVKLWQVDTHKIAGTLSGHRRGVGDVKFNSHKLASCSGDMTIKIWNISEKSCLQTISGHSCAVFRVIFNDSQLISADSAGIIKIWTIK---------TADCECSIDAHTDKIWSLSKNESEFVTAGTDGRIVVWKDVTEEKQKAEDNKR--REAIEQDQ 657
12 -59.100[A] KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  18  301.........................................................................................................SVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQNIKTSAKIKSFDLIHSPHGEKAVFLLQNNLVELYSLNPSLRITIGGHRSDVRTL-SFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQFVTGGADKSVKFWDFELVKDENKQTRTLQLDEDVLCVSYNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFKSHLFFTAGKDHKIKQWDAD---------KFEHIQTLEGHHQEIWCLAVSGDYVVSSSHDKSLRLWERTREPLI--LEEEREMEREAEYEE 725
13 -58.500[B] KOG0273 Beta-transducin family (WD-40 repeat) protein  ali follow..  18  136........................................................................................................................KNREATVNGEENGAHEINNHSKPMEIDGDVEPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSGGHDVPSNKDVTSL-DWNSDGTLLAMGSYDGFARIWTE-NGNLASTLGQHKGPIFALKWKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMFASCSTDMCIHVCRLGCDH---PVKTFQGHTNEVNAIKWSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFDGKYLASGSFDKYVHIWNTQ---------SGSLVHSYQGTGG-IFEVCWRGDKVGASASDGSVCVLDL....................... 522
14 -58.400[A] KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  14  251.........................................................................................................EDDVENVVEKDALKEESTKEAEDVNHIKNEDETKSHPFFYKKITRHYLAEPRKEQRDVQLTAANYNTRTKVLVVAFSSGAFYLYELPDVNIHSLSISDYPISAA-LFNCTGDWVALASREGQLLVWEWQSEQYIMKQQGHSSEMTCIAYDGQFIATGGEDSKVKLWNTQSSFCFVTFSEHTSGVTGIQFSRNKLVSSSLDGTVRAFDVNRYR--NFRTFTSPNPAQFSCVAVSGELVVAGGQDVDIFLWSVKTGKLLEIISGHEGPVVSIAFTSSTLVSGSWDKTVKIWNCLESNSEHETIDAVSDVTNVTFSGEEIAVATLSGNITIFDIKSAGQVTTIETDIITARKNAQANYFSTIEYDGECILAAGKSANICIYHVREAILLKKFEGLNDFISRKHLSE 687
15 -58.100[S] KOG0282 mRNA splicing factor  ali follow..  16  205............................................................................................................................VAKPSEEEQKELDEITAKRQKKGKQGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGRRCLRTFIGHSKAVRDICFAGTQFLSAAYDRYLKLWDTETGQCISRFTNR-KVPYCVKFNPDEFVAGMSDKKIVQWDIRSGE---IVQEYDRHLGAVNTIVFENRRFVSTSDDKSLRVWEWDIPVDFKYIEPSMHSMPAVTLNGKWLACQSMDNQILIFGAQNRFRLNKKKMVAGYACQVDFDMSYVISGDGNGKLNIWDWK---------TTKLYSRFKAHDKVCIGAVWETSKVITCGWDGLIKLWD........................ 579
16 -57.700[JT] KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1)  ali follow..  19  2..................................................................................................................................................................................................KPILLQGHERSITQI-KYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADTKHVLTGSADNSCRLWDCETGKQLALL-KTNSAVRTCGFDFGGIMFSTDKQMVSFFDLRDPDNNEPYMKIPCNDSKITSAVWLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLDMTMFVTASKDNTAKLFDSTTLEHQKTF-RTERPVNSAALNYDHVVLGGGQEAMDVTTTSTRARFFHLAFEEEFGRVKGHFGPINSVAFDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA............ 325
17 -57.400[R] KOG0645 WD40 repeat protein  ali follow..  21  1..........................................................................................................................................................................................................SGHTGRLVAAHPMLPLFATSSQDKSVRIYNSNTYNLVHVIDGHTRSIRRVAWRRPVLAVASFDSVVSINEKDDWECTAALEGHENEVKCIAWSCNGLATCSRDKSVWIWEATEDDEFDCLAVLQEHTQDVKVVTWTEDLLVSGSYDNSICFWDGDDWALTCQLQGHTNTVWALAFNGNTLASADNDGNVFLWIKISSNQTSLPHIHKGAVYTISWMNDTLCSAGGDGKIVVYQREKHDE--ALWHVAYEQDHAHGVYEINSLEYLDDRLLSGGDDGECRVWSFK...................... 322
18 -57.400[S] KOG0308 Conserved WD40 repeat-containing protein  ali follow..  16  15...................................................................................................................................................KISFIIRDEHEYSNRSAVSALQYDAQNGRLFTGGSDTIIRTWSVPHHKQGSLEQHTDWVNDM-ILCGHGKILISASNDTTVKVWNIERDNFIDCIRTHKDYVSCLAYIVEKAVSASFDHNIFVYDINANKTVNNLIGCKDSIYSLATTPNLVLGAGTEKCIRLFDPRTNE---KIMKLRGHTDNVRALVVDGTRALSAGSDATIRLWDIGQQRCIATCIAHEEGVWTLQVSFTTVYSAGKDKMVVKTPLYDFTKSQLLFKEEAPVKKLLLSEKSLWVGTWKSDIKRWSIRPSAQLSIGGDQSTPELVIPGAPAIKKHAMDKRHVLTRDSDGNVALYDVLAARKIKDFEEVVDENSRQVYI. 447
19 -56.900[S] KOG0293 WD40 repeat-containing protein  ali follow..  16  64....................................................RKSEFVRIITRALYSLGYDKTGAMLEEELHNSTIKLFLQQVKD-LEQKFLEFLKVEKIADALRTLRN-SFISHTTSTPGKESVNSRSKVLEELQTLLPASVECLVENSLHIQRDSCVFHNTLDSDLSLYSDHQCGKHQIPSQTAQILESHTDEVWFL-QFSHNGKYLASSSKDQTAIIWEISADSLKHTLVGHHKPVIAILWDDRQVLTCGAEEVIRRWDVDSGDCVHMYEKGGISPISCGWYPDGIIAGMTDRSICMWDLDGRE---KECWKGQRTQKVSDIAMDGKWLVSVCKDSVISLFDREATV--ERLIEEEDMITSFSLDNKYILVNLLNQEIRLWNIEGDPKISRYKGHKRSRFIIRSKQAFIASGSEDSQVYIWHRS---------TGKLIVELPGHAGAVNCVSWSPHMLASASDDGTIRIWGLDRINQQNQKLVQGSSSNGVIHR. 585
20 -56.700[T] KOG0279 G protein beta subunit-like protein  ali follow..  26  2.............................................................................................................................................................................................AEGLVLKGTMCAHTDMVTAI-ATPVDNDVIVTSSRDKSIILWKLTYGVAQRRMTGHSHFVQDVVLDGQFALSGSWDGELRLWDLATGESTRRFVGHTKDVLSVAFSTDNIVSASRDRTIKLWNTLGECK-YTISEADGHKEWVSCVRFSPNTIVSASWDKTVKVWNLQNCKLRNTLAGHSGYLNTVAVDGSLCASGGKDGVILLWDLAEGKKLYSLEAG-SIIHSLCFSPNYWLCAATENSIRIWDLESKSVVEDLKDGSTGIGNKTKVIYCTSLNWDGNTLFSGYTDGVIRVWGIGR..................... 325
21 -56.000[S] KOG0296 Angio-associated migratory cell protein (contains WD40 repeats)  ali follow..  18  1....................................................................................................................................................MAEEEENQELYIAENEVEEVKLMDQGVTEDEAEQEQNDTMNNMVMDSVQGFFEHKDSVFSVSINPVHSNLCASGGGDDLGYIWDITTGEQICQLTGHKDSIVAIDWDGTYIATGGMDSQVRLWKSSTGFEFITAFETVDEIVWLSWHPKGLAAGCNDGSIWMWSLPSGK---VVQVMYGHTAPVNAGKFVGKRLATVDDSGTLIVWNPATGAPECRMEETAAGWTSFDCEGNVLFLGGSSGKVKVVNINSSHILASLEAQTESVEAIALALPICACASVDGTVALYDSASLK----------FRKSLPHEQAVIDCKFNTPYLLTACADCVIRKWDVRSGQLLGEYTGHQEPILCMAIT. 377
22 -56.000[I] KOG0301 Phospholipase A2-activating protein (contains WD40 repeats)  ali follow..  16  2................................................................................................................................................................................ADDGLGDVPMETESMPQYTIHVIEAHKSDTKALAVTQ--GGCLISGGRDETVKFWAKKGKKTHAFEQPKGITVNSIAYDGWRLFVGRRDGTIAVFGPSQAEPYAIFNEHKQNVCCLHINEKAMLSGSWDSNVIIWPITELNSSFTTIVCPGHTLSVWALASLPNTYLSASADKTIRMWF--GDTTLSVFKGHTDVVRALVVSSSHFLSAGNDGHIIHWDVASASILRKFATQAHEIYSMTLSDSHILTTGEDGTLEFWAIDGGKDGN--LAIVSEAVIQLPTTNTWDAKVLNSDIAVAGSDGRIYIMTTDKNRDDDILDAFDAEVVAKLTAK 346
23 -55.900[D] KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats)  ali follow..  17  2.....................................................................................................................................................................................................SLCGHTSPVDSV-AFNSEEVLVLAGASSGVIKLWDLEESKMVRAFTGHRSNCSAVEFFGEFLASGSSDTNLRVWDTRKKGCIQTYKGHTRGISTIEFSPDGVVSGGLDNVVKVWDLTAGK---LLHEFKCHEGPIRSLDFLEFLLATGSADRTVKFWDLETFELIGTTRPEATGVRAIAFDGQTLFCGLDDG-LKVYSWEPVICRDGVDMGWSTLGDFCIEGKFIGCSYYRNSVGIWVSDISESERMGSGPRGSVSPDYETREIKNIYVTGGNLNVAQNPGSLKATLPLESGKVATM--VSEKQNAAYFG. 340
24 -55.000[Z] KOG0318 WD40 repeat stress protein/actin interacting protein  ali follow..  14  21...........................................................................................................................TQRGQPIVLGADPKGKNFLYTNGRNIENPAIADVYTEHSCAVNVAKYSPSGFYIASGDASGKIRIWDTVNKEHLLKNEFQPIAGPIISWSPDNQRIVAVGEGRFGHVFMSETGTSVGEISGQSKSINSADFRPARIVTGSEDNTIAVFEGPPFKFKMTKQDHSRFVQAVRYSPDGFASAGFDGKVFLYDGTSSELVGEFG-SPAHKGGVYALAWDSTQLLTCSGDKTCRLWTVESRELVSEFMGTTVDDQQVSCQGDNLITVSLSGVITYLNVADSKPLRVVKGHNKPITVLGLDRSTIYTGSHDGVVTNWNSGSGTNDRITG--------TGHGNQINGIAAWGDFVYTCGIDDSLRQFSVEGNSYTDYVVKLNCQPRGLAILR 418
25 -54.700[B] KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats)  ali follow..  14  388...................................................................................................................................................GAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIP-PNLAGIPGGKPAYSF-HVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTIPTRHVYTGG-KGCVKVWDISHPGNKSDCLNRDNYIRSCKLLPDGLIVGGEASTLSIWDLAAPTP-RIKAELTSSAPACYALAIDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIDGTKLWTGGLDNTVRSWDLREGRQLQQH-DFTSQIFSLGYTGEWLAVGMESSNVEVLHVNKPD----------KYQLHLHESCVLSLKFCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDIS. 748
26 -54.700[R] KOG0288 WD40 repeat protein TipD  ali follow..  17  147............................................................................................................................RVQKAETENKMLIDRWMLQKMQLNEANDLYEEMLAKLKANGLETLARQQVDGIVRRNEDGTDHFVESPSTCANRIHAHEGGCGSI-VFEYNSGTLFTGGQDRAVKMWDTNSGTLIKSLYGSLGNILDMAVDNKSVIAATSSNNLFVWDVSSGRVRHTLTGHTDKVCAVDVSKFSVVSAAYDRTIKLWDLHKGYCTNTV----LFTSNCNAICLDGLTVFSGHMDGNLRLWDIQTGKLLSEVAGHSSAVTSVSLNGNRILTSGRDNVHNVFDTRTLEICGTLRASGNRLACISPDDDYVAAGSADGSVHVWSLS---------KGNIVSILKEQTSPILCCSWIGKPLASADKNGYVCTWT........................ 515
27 -54.600[BK] KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily  ali follow..  15  5...............................................................................................................TKVEAKRVFIGAGCNRVVNNVSWGASGLVSFGAQNFCPKTAQILTTLPGHKASVNCTHWLPDRQYLLSGDSDGIIILWELSTLNLQLPLSHKKGVTCIYMVSETDAMFASASSDGVVNVWDVSFPVCLDSICVDTKAIVTLSLGRFALALGGLDNKIKLYSGERTTSVCELKGHTDWIRSLDFSLPLLVSSSQDKVIRIWKLVLVGQISVESVLIGHEDWVYSVEWQPLSILSASMDKTMMIWRPEKKTCVGELSHCALGFYGGHWNSLSILAHGYGGAFHLWRNVSSQMQKVPSGHFAAVTDVTWTGEYLLSVSQDQTTRVFSAWKNDEGNEAEHELARPQVHGHDINCVAMVQGNHRFVSGAEEKVVRVFEAPLSHTCAGGEGSFPEDLQADVQ. 527
28 -53.800[ABO] KOG1446 Histone H3 (Lys4) methyltransferase complex and RNA cleavage factor II complex, subunit SWD2  ali follow..  16  2........................................................................................................................................................................................KIKLIDSVVRSFKVAKIFRENTDKIIDFAPNGEHLISCSEDDQIVIYDCEKGTQSRTVNSKKYGVDLIHFTHAIHSSTKVDDTIRYLSLHDNKYLRYFPGHTKKVISLCISPVEFLSGSLDKTLRLWDLRSPN---CQGLMHLSGRPIAAYDPEGLIFAAGVNSESIKLYDLRSFDTFKLNQEKECDWTGLKFDGKTILISTNGSVIRLVDAFHGTPLQTFTGYPNIPIEASFDSQFIFSGSTDGRVHIWNAD---------TGNKVSVLNGHPGPVQCVQFKYMMLASACTNMAFWLPTSEEG.................... 316
29 -53.500[A] KOG0640 mRNA cleavage stimulating factor complex; subunit 1  ali follow..  15  31............................................................................................................................LEKFAMELSMLVKADQCAPSERGMQTLSDKDKTNSDDVLPGIDLEFEPEASALAPEP----------HSYETAYVTSHKQACRAG-AFSCDGSLVATGSVDASIKILDVERMPVIRTLYDHTDEVSYLEFKEHILASASRDGTVKLFDIAKPSVKKKVFTDCEPVLCLSFHPTGVAIGTEHNVLRVYDVATTQCFVSAIPSQQHKAGVTCVKYTGKLYATGSYDGDIKIWDGISGRCINTIAEAHGGICSLEFNGKYLLSSGMDSLVYLWELCTSRPIQTYTGQEHQTEAVFNEDYVLFPDEATTSLCSWNSRNGC--------RLTLNSLGHNGPVRYITHNGPAFLTCSDDFRARFWYRRANN................... 423
30 -53.100[U] KOG0277 Peroxisomal targeting signal type 2 receptor  ali follow..  19  4..............................................................................................................................................................................................VCGGAARMLRTPGRHGYAAEFSPYLPGRLACATAQGTLLILDPEAGLRLFRSFDWNDGLFDVTWSEHVLITCSGDGSLQLWDTAKAGPLQVYKEHAQEVYSVDWSQTRVVSGSWDQTVKLWDPTVGKS---LCTFRGHESIIYSTIWIPGCFASASGDQTLRIWDVKAAGVRIVIPAHQAEILSCDWNENLLVTGAVDCSLRGWDLRNRQPVFELLGHTYAIRRVKFSASVLASCSYDFTVRFWNFSKP--------DSLLETVEHHTEFTCGLDFSPTQVADCSWDETIKIYDPACLTIPA................ 323
31 -52.800[A] KOG0284 Polyadenylation factor I complex, subunit PFS2  ali follow..  16  1........................................................................................................MNGGMMRG------------NQMPNVTLTIQPSTSSMQNSQPRIMNNHHHPHNRFQREHVMPDVMGDGPGRRAVPADSTPDVPVDCILTKFITAMNKVKCPVYSV-CWSPEGKRLITGCQTGEFTLWNGTAFNFETILQAHDSAIRALKWNEQWLLSADQGGYVKYWQPNMNNAHMFSAHKDEAIRGLAFAPTDFATASDDGTARVWDFARYT---EERVLRGHGAEVRCIDWTKGLIATGSRDTPVKIWDPKSGSCLATLQEHKSSVMAVEFNGNWLLTGGRDHLVKMYDIRMMKEMRTYRAHKKEVISLAWHPGLFVSGGGDGSIVYWMVDGEK--------EIGLLEHAHDQAIWSMKWLGHILATGSNDNNTKFWARNFGLSNTNMIGHLDKEREPRMA. 449
32 -52.700[R] KOG0289 mRNA splicing factor  ali follow..  15  26.....................................................ERRLIEKYIAENGTDPIN------NQPLSEEQLIDIKVAHPIRPKPPSATSIPAILKALQDAVMLHSFTLRQQLQTTRQELSHALYQHDAACRVIAAAREALATLKPQAGLIVPQAVPSSQPSVVGAGEPMDLGELVGMTPEISHVGLHSASIPGILALDLDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGLLSSSDDQYWAFSDIQTGRVLTKVTD-ETSGCSLTCAQFDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFNGYYLATAADDSSVKLWDLRKLKNFKTLQDNNFEVKSLIFSGTYLALGGTDVQIYICK-----------QWTEILHFTEHSGLTTGVAFHAKFIASTGMDRSLKFYSL....................... 504
33 -52.300[S] KOG1407 WD40 repeat protein  ali follow..  20  2.....................................................................................................................................................................................EETTIPFKSL---HSREYQGHKKKVHSV-AWNSNGTKLASGSVDQTARIWNIESKAKDLELKGHTDSVDQLCWDSDLVATASGDKSVRLWDARSGKCTQQV-ELSGENINITYKPDGVAVGNRDDELTILDVRKFKPLH----RRKFNYEVNEIAWPGDFFFLTTGLGTVEVLSYPSLKPLDTLTAHTAGCYCIAIKGRYFAVGSADSLVSLWDISDMLCLRTFTKLEWPVRTISFSGEYIASASEDLFIDIANVQ---------TGRTVHQIPCRAA-MNSVEWKYNLLAYAGDDKNPKYNTDEGVFRI................. 309
34 -52.200[A] KOG0299 U3 snoRNP-associated protein (contains WD40 repeats)  ali follow..  13  1MSDPFFTRPEHRKRKARSATSKREKENQKLERNGPANED------LASISSESEFNGFEDEIDE-----------------ENEDTYETAAEKRLRLAREYLDEVKNELVEDGGFDAKEVDRELLASRLKEDVLEKKGQLDYTSKINPDVKIETAQLRGRHMRPLVGVVAYENF--VYSADKSGLIQKWEALQEKDRSRRGENDHVKEILAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMGTNEMFSCSADRSIKVWSLDQMSYIETLFGHQDVIFGVDALAREVSVGGRDRTSRLWKIVEESGGTSMKATAGYMEGSVDCMIDEDHFVTGSDNGVIALWSVQRKKPLFTYPLAHGLDPILAPGRH--------------SAETSPDPVTIPPQPRWITSLAAYSNLFASGSWDGNIRLWKIAEGLR---SFEPLTIATPLSVYGCINSLSLSLQVFAACGRETRVGRWKTLRGIPNSGF-VFNIPLTVIPSV. 516
35 -52.200[R] KOG0315 G-protein beta subunit-like protein (contains WD40 repeats)  ali follow..  13  1....................................................................................................................................MGDQQQLILATGGYDHTIKVWQKTMRFVETSQVNALDRTPDKTRLAACGYQCI-RLYDLESNCTAPVINFDGVQKNVLGFQEDGNWMFTAGEDHHVRIWDMIAAPHCSRIFDCEAPVNAACLNQVEIAMGSQNGSVFLWDVKSERHERIVPEVDASIQDVAISPDGLAAANNKGNCYIWSLTSQDTLRPNRKIPAHSRYILRCKFDSRLLLTTSGDGTVCIWKTDDFSKWRELCIENYWVWDAAFDSKWLFTASSDGIARLWKLQTKSSIRDYTGHTKAITALSFEIPVKSTNISDVQSSAKPPT---------------QRDNPPGTNNLAFFVGRVAMNPYMGNTTTELN........................ 362
36 -52.100[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  13  391..........................................................................................................................................................SRYLRERFLRCLDLYLCPRAKRVKLNIDAEYLIPKLPSPRDLQVYRGHTDLVRSV-SVEPKGEYLVSGSDDKTVKIWEIATGRCIRTI-ETDEVVRCVAWCPNSIIAVATGNRLNAEADEQEKGVRVVITHFKPIRQVTWHGRGLATVMPEGANRSALIHQLSKRRSQIPFSKSKGLIQFVLFVKPCFFVAT-QHNIRIYDLVKQELVKKLLTNSKWISGMSIKGDNLLVSTYDKKMLWFDLDSTKPYQTMRLHRNAVRSVAFRYPLFASGSDDQAVIVSHGMVYNDLLQNPLIVPLKKLQTHEFGVLDVNWVQPWVFSTGADSTIRLYT........................ 784
37 -52.000[A] KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats)  ali follow..  17  156................................................................................................................AERRRRLKELLAGLGENAINKRQYEDEERKQQQREQDQATWYHEADYSLPRAKDRLVRAREALEVPSAARAGRMVEMQKKLQSLAPLCSQVGDTRPVAAFSEDSSLLLTSSWSGLCKLWSVPDCELKQTLRGHASYVGGVALNVVAMASGGHDGAVKLWGFNNEESIADITGHPHRVSKVAFHPSGLATACYDSSWRLWDLEQKTE---VLHQEGHAKPVHCLSYDGSVLVTGGLDAFGRVWDLRTGRCIMFLEGHLGAVFGVDFNGFHIATGSQDNTCKIWDLRRRQPVYTIPAHTNLISDVKYQGSFLVTCSYDSTTKIWSNK---------TWQPLKTLQGHDNKVISVDINSQYIATTSFDRTFKLWSPDS..................... 553
38 -51.900[S] KOG0310 Conserved WD40 repeat-containing protein  ali follow..  13  1.................................................................................................................................................................................MAQPYLPAEKFLSRKQETILLDEDEPAVVSSV-RISPKKPYHVATTSSVRLTLYDTVVCEPLNLFSRFKKGVCSIDFDGRLLAIGGDEGKVRIFDVESKVALRVMQASQSTVKSVHFSPRGVFSMADDGKIKQYRVADTANAVPIIEIQAHEDAIRCGAVNDHIVLTGGYDHKVRLWDIRSKEKSLEL-DCEHPVESVLFLGEQLIATAAGPIVKIWDTTTGRQLTALQAHYKTVTSLRLNSTCLLSAGIDRRVNAFRTTNYSLINSW----------SMPSPVLDIDVDDQTMAIGMGNLLALYRRAEIKKEATASAAIEDKRSLIRTS. 338
39 -51.900[R] KOG2394 WD40 protein DMR-N9  ali follow..  11  4.........................................................................................................TSNGMISAPSSSSSPAANPQSPGIKTYFKTPEGKYKLHYEKTHSSGLLHYAAQLKERAAPSTPTGTSSGYSASSGFRSATARLLGTGNGSALSFVGGNGGGKSVTNFDGKGTYLVFNVSDAFICDLNSQEKDPVKSIHFSNSNPMCHAFDGHDLLIGLNSGDVYTVSLRQQLQ-GSVNNRQDRCTSISWVPGGAIRDPTQFSVDKAKYSKSNP---VARWHICQGSINSIAFDGAHLATVGRDGYLRIFDFLTQKLVCGGKSYYGALLCCSWDGKYILTGGEDDLVQVWSMEDRKVVAWGEGHNSWVSGVAFDSNRFGSVGQDTQLLLWDLEMDECKRDVPKLSPIIAHRVHTEPLSGLMFTQESVVTACREGHIKIWTRPSESETQTNSNPTTALLSTSFT. 537
40 -51.800[T] KOG4378 Nuclear protein COP1  ali follow..  15  4.................................................................................................................................................................................................................NLVEPSWRLLAASGGD-TVKLFDVSADSVLSYTPSPGCAVNSVKWTNLVVASTGEDKKISLWRKNGQSLGTVGDSAEECLSAISFSKKGICSGGTGQIVKIWDLQRKL---CIKKLKGHTSTITGVMYKDEHLASVSVGGDLIVHNLASGARATELKDPNGQLRLLDYSRHLLVTAGDDGTVHLWDTTGRSKMSWLKQHSAPTAGVCFSPKIIASVGMDKKLYTYDSGSRR----------SSSCIAYEAPFSSLAFNGYILVAGTSNGRVVFYDIRGKPTVLHAFSNSEDVTSLSWQ. 324
41 -51.600[R] KOG0646 WD40 repeat protein  ali follow..  20  2......................................................................................................................................................................................................................EITVIASSSIDEGIGSWDLKTGTEQLQFKPCASPAHGLTAVSSQLSARNTSGSIFYWSWTKPQ-AEVKSYPVEPIKALAANNEGLVGGGISGDIYLWEVATGK---LLKKWHGHYRSVTCLVFDDSLLVSGSQDGSIRVWSLIRTLYEHNFNEHTMSVTDIVIDNAVIISSSEDRTCKVWSLSRGKLLKNI-IFPSVINALALDGCVFYAGARDSKIYIGAINAT----SEYGTQVLGSVSEKGKAITCLAYDGNLLISGSEDGVVCVWDPKSLRHVRTLIHAKGSRKGPVNN. 314
42 -51.500[S] KOG0772 Uncharacterized conserved protein, contains WD40 repeat  ali follow..  13  1........................................................................................................MDDNTAPKKEKKARVFEPTHVPQSVSVSSKSESGVSSSAVSDDEDDFMPDFQMQQSEAGPSSSRAEGPEDSDDSDFDETEAISIIKLIPAAEAKISHGTQAISAL-RVEPPGVRFASGGLDYYVKLFDFQKMDMSELLPAESHVINSLAFNGETLVVASGEAIIRLLDRAGKQWLNITKGHTATVNCVEFNPLNFISCSDDGSLRLWNLDDHKKVIKTKGANGKRVSPQVCTFDGKWIAAGCDDGSVQAWKYGSQYVYLVRKAHNGSITSIAFDSKRLLSRGFDDTLKMWSLDNPKLVKTGLENAFKSTDCGFRAEVVFTGTTPGTLQFFDPM---------TFDLVYKIDYPGISCHRIQWRLNQIIAGLSDGTIHVYYDQTMSQRGVMSCVTKPLKRNRAS. 469
43 -51.200[S] KOG0321 WD40 repeat-containing protein L2DTL  ali follow..  16  76...................................................................................................................................................KKPAQLCKELLIRQLGGSRSHPFSTKTSRHVGGRLNLETYYSRPSE----CLMMLNQLPFCL-GFANNESLLAVCTETGALELFDSRSARRIHGWLAHNNAIFSVNFDDSLLATSSGDQTSKVFDLSTQQCITRLGYHSHSVKQVNFCNDSLVSCSRDGSIIFWDMRTHGRIRKAHENSGRDCSITSATWLPQVISSCSANSALKLWDLRTVHTVRTTSKRDFGVTNVCTDGERIYAASRDSIIYEYSSRHLNYKDPRLRISSFYVKLACDGATLACGGKTSGVVVFDTTRN-------CSSSAMLTGGHTKDVTAVDWSEGQLASISDDGSVRVWNSSLHGSAANLEKNFSEIFYWGFSE 489
44 -51.000[A] KOG1272 WD40-repeat-containing subunit of the 18S rRNA processing complex  ali follow..  9  1...................................................................................................................................MEISSEDNNLMEKQVLTWTLIQICMQESDVELETKVKKYLRGEGANLETLKDKKLKTQLASREKLYGKSAKAAAKIEKWLLPAEAGYLETEGLEKTWRVKDILSSRNQYDIVLPDFGPYKLDFSGRHMLAGGRKGHLALLDMMNMSLIKEIQKERGPVARLRFLKNHLASVNMSGQLHYQDVTHGG---MVASIRTGKGRTDVMEVYNSVVGLGHSGGTVTMWKPTSQAPLVQMQCHPGPVSSVAFNGHLMATSGKERKIKIWDLRKFEEVQTI--HSFHAKTLSFSQKGLLAAGTGSFVQILGDSSGGSSH--NYTRYMNHSMVKGYQIEKVMFYEDVIGIGHSMGWSSILIPGSGEPNFDSWVANP-FETSKQRR 431
45 -50.800[Z] KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC  ali follow..  17  1......................................................................................................................................................................................................MSLHQFLLEPIHAWNRDRTQIALSPNNHEVHIYKKNGSQKAHELKEHNGHITGIDWKSDRIVTCGADRNAYVWSQKDGKPTLVILRINRAATFVKWSPLEFAVGSGARLISVCYFEAEND-VSKHIKKPIRSTVLSLDWNNVLLAAGSCDFKCRVFSAYIKESEFGGSGTGGWVHGVSFSGSRLAWVSHDSTVSVADASKSVQVSTLKTEFLPLLSVSFVSESVVAAGHDCCPMLFIYDDNMDKRATTEDRNTALETLHQNSITQVSIDCRKFCTTGIDGAMTIWDFKTLESS................. 363
46 -50.600[R] KOG4227 WD40 repeat protein  ali follow..  15  4..........................................................................................................................................................RAGLGGSMRSVVGFLSQRGLHGDPLLTQDFQRRRLRGCRNLKKDLLGHFGCVNAI-EFSNNGQWLVSGGDDRRVLLWHMEQAKPIQLKGEHHSNIFCLAFGNTKVFSGGNDEQVILHDVESSETLDVF-AHEDAVYGLSVSPVNFASSSDDGRVLIWDIRESPHGEPF-CLANYPSAFHSVMFEPRLLATANSKEGVGLWDIRKPQLRYGGNLSLQSAMSVRFNGTQLLALRRRLPPVLYDIHSRLPVFQFDFNSCTMKSCCFAGQYILSGSDDFNLYMWRIPADPEAGGIGVNGAFMVLKGHRSIVNQVRFHTYMICSSGVEKIIKIWSYKQPGCTGDLDGRIEDDSRCLYTH 386
47 -50.500[S] KOG1409 Uncharacterized conserved protein, contains WD40 repeats and FYVE domains  ali follow..  13  18....................................................................................................................................................GAKPALLHRITGHVARINDVILLSKDEGVWTASDDRSVRLYLKRDNDQFWPSIHHFMPVAPLYYSEETYKLLVGLINGNVYEFDFNSMTESRKWTCHAGPISGLGFSSELIFSCSRDKSIVWHCSENSN---KMGSYLLENSCTAMVIDLVFVGDHGGHVTVLRIVDNQP-NLVSKLSAHTNAITSLTWNKKVLYSGSSDHLIIMWDIGGGREAYELNGHNGKVTTLCAAAKRLFSADEHGKLMCWDMNCKRVETPEWKTSDCCQKCNQNWTTYPPMGYETKIRICNDCNARDNPQNFNLTPLAIPHEIHTGITAMHLTLGLLVTSGQNRVIMIWDVRSVCSAPS--GSQ.......... 415
48 -50.400[R] KOG2096 WD40 repeat protein  ali follow..  14  2......................................................................................................................................................................DSVLVVGIASVILGALIAVLFFGSYFRKRTSEVQSMAKAEPQDPIRNPKSNHPAPKKNHPKSQASDKNQNKDLNTLKGHGDAVTGLCFDGKSLATACADGVIRVFKLDDARFLRINLPAGGHPTAVAFADDADQQGKLPLPSIKWDHHHIHEKRSVLTISGATATY-GTADGSVVIASCSEGTDIVLWHGKTGRNLGHVDTNQLKNHMAAVNGRFLAAAAFTADVKVWEIVYQKRVMQLKGHKSAVTWLCFNSEQIITASKDGSIRVWNINVRYHLDEKVFPIPLCDSGGNPLHYDRLSLCEGKILAASHGSTLQWLCAETGNVLDTAKAHEGDITCISWA. 420
49 -50.300[Z] KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats)  ali follow..  22  26.......................................................................................................................................................................................AASEIADLSNIINKLLKDKNEFHKHVFDFLIKGQFLRMPLDKHEIEYVEKCTAPQPEQCMFHDDWISSIKGAEEWILTGSYDKTSRIWSL-EGKSIMTIVGHTDVVKDVAWVKKDLLSASMDQTILLWEWNVERKVKALHCCRGHAGSVDSIAVSGTKFCSGSWDKMLKIWSTVPTDPIVTLSGHMEAVSSVLWDAEEICSASWDHTIRVWDVGSGSLKSTL-TGNKVFNCISYLCKRLASGSTDRHIRLWDPRTK------DGSLVSLSLTSHTGWVTSVKWHEQQLISGSLDNIVKLWDTRSCKPLYDLAAHEDKVLSVDWT. 395
50 -50.100[S] KOG0294 WD40 repeat-containing protein  ali follow..  17  2.....................................................................................................................................................................................................................PPEMEIIEATNEELLLGFKLIKSPTDGADSSYARSITSLAVQWPWVASGGTDGRIFVYDMRTRKQSQIILSHAGRVNTLKFTPDLLLSGSDDGHMIATRVGSWT--KEYDWQKAHAGAVTHVSCSSKLALSLGGDQVLNTWNLVNGCVAHKTNTLDFQTGCLSWQGDHFTLSG-PLVLEIWGIENAHVMRRIE-MPSKPICITWDGNECLTGLDNGNIAWISLKDE-------DDTPPTFILAHEVRVKAIAYLNEFLATVSIAGQIKVWKIDMETRKLEEIARSFRPTDLGLL. 313
51 -49.900[A] KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats)  ali follow..  15  3....................................................................................................................................................................VKMLSRNPDNYVRETKLDLQRVP----------------------RNYDPALHPFEVPREYNATKLERVFAKPFLASLDGHRDGVNCLAKHPETVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNTFLLGSCASDRNIVLYDMRQATPLKVHMDHVSAVLDVDYTGKEFVSASFDKSIRIFPVDKSRSREVYHT--------KRMQHVICVKWDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQK. 376
52 -49.500[R] KOG1539 WD repeat protein  ali follow..  20  141............................................................................................................................................................QLTGKFTPTSIVHPDTYLNKVLVGSQEGPLQLWNINTKKLYQFKGWGSSVTSC-VSSPALDVVAIGCADGKIHVHNIKLDEEIVTFEASRGAVTALSFSTDLLASGGSFGVISIWNLNKKRLQSVIDAHDSSIISLNFLANELMSASADNSLKMWIFDTNDDPRLLRFRSGHSAPPLCIRFNGRHILSAGQDRAFRLFSVIQEQQSRELNHLLLAILACAISGNFAVVGTAGGWIERFNLQSGISRGSYYAHDGEVIGVACDNTLMISAGYHGDLKVWDFKKRELKSDVVTLKMVREFRGHTDRITDLCFDGKWVISSSMDGSLRIWDVILAKQIDGVH-VDVPITALSLS. 628
53 -48.900[S] KOG0283 WD40 repeat-containing protein  ali follow..  13  263.........................................................................................................DEDGMWNRLSDLQTGKQLTLEEFEKCVGYSPVVKELMRRENVNR--------INYEPLMDLRKFNSYLSKSVRLSKRRGAALLKNIKGVAHSMSLRVADKDVSDTDSPKKGKDHKHGKANEWVKVRELSALHMCQEIQAHEGAVWTIKFDAHYLASGGADRVIHVWEVQECELMSMNEGSLTPIHPSLCDSSGITVVEKKKKGKGSSGRRHNSDKPVCSLKGHLDAILDLSWSSQLLLSSSMDKTVRLWDIETKTCLKLF-AHNDYVTCIQFDENYFLSGSLDAKIRIWSIQDRH-VVEWSDLHEMVTAACYDGQGALIGSHKGICRAYDTEDCKLSQTNQIDVQSNKKSQAKRKITSFQFNPSEVLVTSADSRIRILDGSEVIHKFKGFRNTCSQLSASYS. 691
54 -48.700[U] KOG1332 Vesicle coat complex COPII, subunit SEC13  ali follow..  22  7...............................................................................................................................................................................................................................................TVDTSHEDMIHDAQMDGTRLATCSSDRSVKIFDVRNGGLIADLRGHEGPVWQVAWAHPMLASCSYDRKVIIWREENGT--EKSHEHAGHDSSVNSVCWAGLILACGSSDGAISLLTYTGEEVKKINNAHTIGCNAVSWAIKRFASGGCDNLIKLWKEEEDKEEQKLEAHSDWVRDVAWAPSTIASCSQDGRVFIWTCDDAS-----SNTWSPKLLHKFNDVVWHVSWSANILAVSGGDNKVTLWKESVDVCISDVNKGQGSVSSVTEG. 317
55 -48.400[DO] KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits  ali follow..  16  69...................................................................................................................................................VVMNQNRTRILAFRNKPKSLLSTNHSDSPHQNPKPVKPRRYIPQNSERVLDAPGL-RDDFSLNLLDWGSANVLAIALGDTVYLWDASSGSTLVTIDEDKGPVTSINWDGLDLAVGLDNSEVQLWDCVSNRQVRTLRGGHESVGSLAWDNHILTTGGMDGKIVNNDVRIRS--SIVETYLGHTEEVCGLSESGNKQASGGNDNVVHIWDRSLAQWLHRFEEHTAAVRALAWFQASLLAGVGDGKIKFWNTHTGACLNSVETGSQ-VCSLLWSQSLSSHGFTQNQLTLWKYP---------SMSKMAELNGHTSRVLFMAQNGCTVASAAGDENLRLWNVFGEP-PKTTKKAASKKYPELFS. 438
56 -48.000[S] KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains  ali follow..  13  147...................................................................................................ETVYFIASVVVLYNVEEQLQRHYAGHNDDVKCLAVHPDRITIATGQVWDWQKEEKLADVKCSNEAVFAADFHPTDTNIIVTCGEITSLLLDTRRKLPLIRSSRTRKAKVVLCVTFSNGDTITGDSSGNILVWGKGTNRISAVQGAHEGGISPLCMDGTLVSGGGKDRKLISWSGNYQKLRPITQGHTDELWGLAIHASKFLTCGHDKHATLWDAVGHR----PVWDKIIEDPAQSSGFSGSVVAVGTLTGRWFVFDTETKDLVTVHTDGNEQLSVMRYDGNFLAIGSHDNCIYIYGVSDNGRVGKCSGHSSFITHLDWNSQFLVSNSGDYEILYWVPSACKQVVSVEHVFGVWPEGSDGTDINAVCREKKLLSTGDDFGKVHLFSYPCSQPSHIYGGHSSHVTNVDFL. 695
57 -47.400[YU] KOG2445 Nuclear pore complex component (sc Seh1)  ali follow..  15  3....................................................................................................................................................................................................PFDSGHDDLVHDV-VYDFYGRHVATCSSDQHIKVFKLDNWELSDSWRAHDSSIVAIDWAGRIIASASYDKTVKLWEEDPDQKLCTLNDSKGSLYSVKFAPAHLACLGNDGILRLYDALEPSDLRLSIPPANHLQSDFCLSWCPSEKLAVSALEQAIIYKDGKLHVAAKLPGHKSLIRSISWAYQLIATGCKDGRIRIFKITEKLSPLASEESLTNSNMFDNDVDMDAQGRSDSNTEEK-----AELQSNLQVELLSEHDDHNGEVWSVSWTGTILSSAGDDGKVRLWKATYSKCMSVITAQQ.......... 349
58 -47.400[R] KOG1334 WD40 repeat protein  ali follow..  13  215.........................................................................................................DEDQALEEWISSETSALPRSRWQVLTALRQRQLGSSARFVYTFVQRFRLQYLLGSHAGSVSTIHFNQRGTRLASSGDDLRVIVWDWVRQK-PVLNFESGHDINVIQAKFGDSTLAMCGHDGQVRVAELINASNTKRVAKHRGPAHELALSPYKFLTSGEDAVVFTIDLRQDRVVTRENDKKVGLYTISMNPANFAVGGHDQFVRIYDQRRIDKKENNGVYCDFPTNITCVVYDGTELLASYNDEDIYLFNSSLSDGAQYVKRYKGCVNFYGPRSEFVVSGSDCGHVFFWEKSSSQIIQFMEGRGDIVNCLEPHPYVLATSGLDQHVRIWT----------PTAKTATELTGLKDVIKKNKQDEDNLNYTDSFDNRMLRFFVRH--LLQRAHQPGWRDHGAEF. 652
59 -46.700[A] KOG0647 mRNA export protein (contains WD40 repeats)  ali follow..  16  1................................................................................................................................................................................................................MSFFNRSNTTSALGTSTAMANEKDLAND--IVINSPAEDSISDIAFSDFMFSASSWDGKVRIWDVQNGVPQRAQHESSSPVLCTRWSNDGVASGGCDNALKLYDIASGQ----TQQIGMHSAPIKVLRFNTECIVTGSWDKTIKYWDMRQPQPVSTVMMPER-VYSMDNKQSVVATAERHIAIINLANPTTIFKATTSPLKWQTRCVACEADGYAIGSVEGRCSIRYIDDGMQKKSNPNRAPGSNGQSLVYPVNSIAFLYGTFVTAGGDGTFNFWDKNQRHRLKGYPTLQASIPVCSFNR 321
60 -46.100[R] KOG2055 WD40 repeat protein  ali follow..  13  179...........................................................................................................................LKSLFKSSVSYINQSSKLLAPGTINIKRLKDANFQAPSHSGIRCMSIHPYFPLLLTCGFDRTLRIYQLDGKVNPLVTSLHLRSSALALFHPDGKRVIAAGRRKYMYIWDLESAQVQKVQENFQPSMERFHVTGKYIALEGRSGHINLLHALTGQFATSF-KIEGVLSDVLFTSDGMLVLSYGAEVWHFNVEQRSVVRRWQVQDGVSTTHFCLDPSNKYLAIGSKSGIVNIYDLQTSKPVTTLDNITFSINSMSFDSQVLAIASKKDTLRLVHVPSFSVFRNWATPLGRVTCLAFGKGELCVGNEAGRVGLWKLA---------HYDLKFVPDKIINWEIRLGKFGYVLLGIQVDVVI............................ 555
61 -45.700[R] KOG1273 WD40 repeat protein  ali follow..  15  2........................................................................................................................................................................................NAPIIDPLQGDFPEVIEEYLEHGVIKCFNHRGSLLAAGCADGGCVIWDFETRGIAKEIRDNSAAITSVSWYGHRLLVSAADKSLTLWDVSTGEKIARTINPPFSPAAACFNKCGVYIGNSKGEILIVDYKSVRVLALVSA--SGAAPVKNIVFNGQYLLTNSHDRTIRIYENLLPAKNKMKTVGSKCLTCFSGDGEWVVGGSGEHKIYIWD-RAGHLVKILEGPKEALIDLAWVHPIIVSVSLAGLVYIWAKD---------YTENWSAFAPDFKELENEEYREDEFDLIPETEKVKVLDVNEDEEVDIDTVEKDAFSDSDMS. 411
62 -45.700[KL] KOG4283 Transcription-coupled repair protein CSA, contains WD40 domain  ali follow..  20  4...............................................................................................................................................................................................................................................AIKDRETGRI-------RSNSFANRFKSRRILSLQLSNRKDFVSPHRGSVNSLQVDLRYLLSGAADGSAAVFDVQRATDYEAKQHENGHKYAISSAIWDTGLFITGSFDHYLKVWDTNTAQAVVDFKMPGKAMSSMAMSHTLIAAGTEDVQVRLCDIASGAFSHTLSGHRDGVMSVEWSTSVLYTGGCDGAIRFWDIR---------RAGCFRVLDQSQTQL-GFRPPILKRTAVGSKVC............................. 253
63 -45.300[R] KOG1524 WD40 repeat-containing protein CHE-2  ali follow..  9  69...................................................................................................................................QTKGGQNDVFAVSTSDGKRNGKVENMVDAHNGAALCARWNSDGTGLLSSGEDGFVKMWSRSGMLRSVLAQFATAVYCV-AWDSTSSNVLYCNADHCY-IKSLKMQVAPIKWKAHDGIILCCDWTSDLIVTGGEDLKFKVWD-GFGQILFNSSVHDYPITSISWNTDGLFAVGSHNILRLCD----KSGWSHSLEKMNAGSVMALSWDGTQLAVGTAAGLVFHAHIIDKRLTNTPTMIEYNERTVNIQCEKIFLVSDGMTITIFTYEINLNPPGQVMALLDERKIDLDTLVVRDRADNKVLHFFDPTTGKAQGD--------GNLKHEHDIVELTVNDRNVAFRDQIGAVHIAMVKTFGVSQRMVKIGSLVEQLVFN. 513
64 -45.300[R] KOG1188 WD40 repeat protein  ali follow..  14  32...............................................................................................................................................................................................................SKTVQAGKENLVAVLCSNGSIRIYDKERLNVLREFSGYPGLLNGVRFSCDSVYSACTDGTVKCWDARVAKPVQLFKGYPSNFISFDINCNDHIICADDALLVFWDARMNSKDSLGAYSETHSDDVTQVRFHPNMVVSGSSDGLVNVFDINIDNALVTTCNSISSVSCIGWGYKQIYCMTHDEGFYWWDLNHLDTDEPVEDALDYLIGGLYHEKHVIGGTNKGRIHLMNCSMS------GLTHVTSLQGGHAATVRSFCWQDDSLLTGGEDAQLLLWKPGAIEKTFTKKESMKIASSVHQR. 372
65 -45.300[R] KOG0322 G-protein beta subunit-like protein GNB1L, contains WD repeats  ali follow..  15  9...................................................................................................................................................................................................VFSLRSPDMGAVNSLCFQESDR-LLAGTIKGSVFLWDLQTNRSALHFEVGSDPITSLHHTPDRLVTQEKGGTITMFSIGGSSYVNHLGFCRSALHTNTSKTNELFYPCEESSIGVLHVTDAAAPTQILVPDDPQLPKLFECASQLFLLAGYESGHFLTWDISSSVIL-DVMELAQDATSVDYDTNRGIVGGPTDKLISFSYQRSQLGSELCIKNPGVNGVRIDQKVFASAGWDGRIRIFSWK---------SLRPLAVLTQHNGGVMDLAFHAPIMAAAGMDGQISLWDLYN..................... 323
66 -45.300[R] KOG2444 WD40 repeat protein  ali follow..  12  12.................................................................................................................................................................................................................MKSNKDGSRLVVGFVDGSIRFYDTQQHEEEFQEFQTKSSIRGVDLHKKRVYAVTKNRSLCVFDIDTGKRVRCIKCHRSVPTAICTLPPTLATADESGEVKTWNLDPEVENANIRKWQEQDEDINDLKVDKSNLLATSSDGTLGAYDLRKAKLKMRSELMHSELYSVCGTNRSVYVGGEDGYVEVFNLNENLLERVESGFEMGVNGIVESGLLGLTSQGSNRMRLLNVQPSKRLGYAGY----GDEKSDDDGIDAITISTDVFTMISMSCTIKKWDMGPIID-EIPILRAQDAKSKKMRK 328
67 -44.900[R] KOG0274 Cdc4 and related F-box and WD-40 proteins  ali follow..  13  8..............................................................LDFTSSNLRRMNRDHSSNNTNRTVLNLPKE----ILIIIFSFLDPRSLLSAQCTCKYWKKLLSDDLSWRTAFFHH----------------------AGDQSQIFSPLGNGTWRQEYLLRSTITRAYEKGKGQTVQYDCRVGQLTNLYYDFSSGRLYSGNWLTGTISVSDPTTGKVERSLGSFTHGLSTMTLGKQIFGFGFMDGRVGVILMSRQAFRYCLDSHADSVTCIDAGEIGMVTGSDDGSVHCWDVKTGV---SLQSFQFRSSQILSLCFRPKMLLVDTFNYELNSYQLYLIPGYARSRKNEQPILLSS-RKCVLTDEEEPPCLMTADCCAGVAFLSRGAPKNCICRVSFGARLLAVGDENGLVYVVNTRTE----DPNKAILRTITAYSNFPITDIYLNEVAMVVGSASGYCGVYDTVTGNFLKKIASARNAARREPINC 483
68 -44.700[D] KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily  ali follow..  15  1.....................................................................................................................................................................................................................................MTTVTPSAGRELSNPPSDGISNLRFNSDHLLVSSWDKRVRLYDVSTNSLKGEF-LHGGAVLDCCFHDDFGFSVGADYKVRRIVFNVGKE----DILGTHDKAVRCVCDVTGQVITGSWDKTVKCWDPRGASGPERTQTYLQPERVYSMSGHRLVVATAGRHVNIYDLRNMSEQRRESSLKYQTRCVRCNGTGYALSSVEGRVAMEFFDLSEAAQAFKCHRKSEAGRDIVYPVNSIAFIYGTFATGGCDGFVNIWDGNNKKRLYQYSKYPTSISALSFSR 307
69 -44.400[R] KOG2321 WD40 repeat protein  ali follow..  8  9............................................................................................................................NNVRVYTVSGEGVTQRLPNWISKRKSHRIELLQDFEYPEASNRIKCTRDGKYAMATGVKPHIKVFDFAEMSLKFERHTDAENVQFEILSDDWTKSVHLQTDRTVDFHSQGGIHYSTRIPKYGRDL-KYHYPNCDLYLAAAGDEVYRLNLEQGRFLNPLKSPTGGVNVIDINPMHLAFGTDAGSVEFWDPRDRSRVGILEPYSDNSRSVTALKYDGLNVAIGLSDGATLLYDLRSSSPYMSDQGYSMPIKSLHWDGTARVLSADSKIIKIWEKDTGKPFSSI-EPTVELNDVCPGTGLILTANEGSPMHAFYIPS--------LNPAPRWCSFLDNITEEMEEDDYKFVTKKELLNLGLDHLVGTGVIRAYM-HGFFIDNNLYEK 423
70 -44.200[R] COG2319 FOG: WD40 repeat  ali follow..  12  88.......................................................................................................FIPMTSNKDTISLGRHSSLSRNLVNKTKNASETYQQLLEYALEVERDDTYAKLQKSDMTQKCPTMVASEKDNKGKLNEKKNRSPENLLPFRILDAPELRDDFYTSLLSWSPKGDLAIGL--AENIYLWSKELGP-TRVLEESIYDVSSVAYNGDILAVGRVDGTLQFWQDNERV-PRISIHHPGDIGVLAWKPVLLLVGKGNGNIFVYDIIWSEAVLVATITNAHDEQVCGLNHDGSQFASGGNDNRVCLFKGSDLRQPLYVWQQNAAVKALSFCRSLLATGSHDKHIRFYNCFNGKKIDELYCGAQ-ITSIHWSYREFSVTTVQHRFAVYSWPQLECLVSVLP-------SVPDIRCVHSVLMTDSIIIASSNETIKFFDLSEESSWHNSRWHGIFDSQILEM. 522
71 -43.600[S] KOG4328 WD40 protein  ali follow..  14  1....................................................................................MATEYERKRLENIRRNMLAALNVRAKASSLLSAAKRSRDDSKSFKKKKP-RMSLRTRGLNPDSAGLPDGFSDFRMGSQITHNQPSPQKQSPRLLAPIPFESAYEGYGSYTQVDTLLGIESKSCRGFSDYVNKEFSIPVKPEKIEFDLDLLTLEPQNVARVVPGRIFVVQFNVKMVAAGDKLGNVGFWNLDCGDGIYLFTPHSAPVSSIVFQQNSVISSSYDGLIRLMDVEKSV----FDLVYSTDEAIFSLSQDEQSLYFGQDYGVFNVWDLRAGKSVFHWELHERRINSIDFNPHVMATSSTDGTACLWDLRSKPKTLSTVNHSRAVHSAYFSGLSLATTSLDNYIGVLSGANFENTCMIYHNN-----TSRWISKFKAVWDDSYIYVGNLSKKIDVINPKLKRTVMELHNPRAIPCRIHCH. 494
72 -43.300[R] KOG1310 WD40 repeat protein  ali follow..  16  1..........................................................................................................................................................MDNLSFHDGNIFNLLHTRSQDPSHEVDQRMQFHSSLVRRLSQQELEGHQGCVNAL-AWNSNGSLLISGSDDLRINIWNYSSRKLLHSITGHTANIFCTKFSDELVVSGAGDAEVRLFNTSRLSPSALYQCHTRRVKKLAVNPNVVWSASEDGTLRQHDFRESTSCPPLADPPKQTLSLKSCDISPHLLLVGGSDAFARLYDRRM-MHLSERGRTNLHLTHVTFSEEVLLSYSGEDRTSYQPEGAIDMKRRYVGHCNVGTDIK-RGEYIASGSDDGRWFIWEKQ---------TGRLMKVLVGDESVLNCIQCHPFVVATSGIDNTIKIWSPTASVPSIVAGGSAGPATANVVE. 711
73 -42.500[R] KOG2919 Guanine nucleotide-binding protein  ali follow..  9  91............................................................................................................................AKPEDQELAIAPVLQYFQGALVELGRRCWT--SSTEAQHYTKGCYWSPDGTCLLVPVHLDGMHVIEMPSDLYSQSEVHVPEGGTVYDCQPETCLWLATRQHEPIHMWDAFDGSLRCSYSGYDMAAISLAFDGEQIYAGY-KRCIKIFDTSRPGRFCDDYPVKFAISCIAQTTAHLTCGNWHGYIQHFDLRCSHKQGPLFTLGGHKGGITQLRYGEFLFSGARKCDKILQWDMRYKQPLVELQRHVDTNQRIQFDSNWLASGDTRGFVNVWDLKKYGDPSVLPLHSDCCNGVALNPAILATSSGQFHFTD------------QSAQGDNVTLNGTETTELPAPVNQNQKEVLYENAVVMWWCGQT.................... 486
74 -42.500[S] KOG0270 WD40 repeat-containing protein  ali follow..  14  131............................................................................................................................SQEEKQELQVYPSDNLVLAARTEDDVSYLDIYVYDDGAGFHSSDIPVEEGDEARGLVRDPALYVHHDLMLPAFPLCVEWLDYKVGSNSEEAANYAAIGTFDPQIEIWNLKKSKTGHITTHHTDAVLSMAHNRSVLASTSADHTVKLWDLNSGNAARSLAHSNKNVSSSEWHMSILLTGGYDSRVALTDVRISDESQMSKYWSMAGEEIETVTFAENIILCGTDSGNVYSFDIRNRKPVWTLKAHDAGISTLCSNGMMSTGAMGEKTVKLWKFPLDSMVLSRDFDVGNVLTSSFAPDTMVIGGVNKVLKLWDVFTN--------RSVRKSFKSELENVQARAKAQKIGKSSRIARKYTSNDNPDTVITIDDQGEDEEEREGGDE. 571
75 -42.300[DK] KOG0973 Histone transcription regulator HIRA, WD repeat superfamily  ali follow..  16  2.....................................................................................................................................................................................................TFVGHDTGSILAIDCHPSGKKFITCTSNGLVVVWNAEP-PKLLFQVESQSQSNSCSPDGKRFAFGSDDSSVSVWEYVGLKECCVLRGHSMEVLTVEWSPNGLASGSIDYRIIIYNARKLP--DRITVLNDIQLPVKGLSWDGKYLASLEGDKKLRFWATDSWQCVKSVTIEETMLTRLDWDGKYLMTPAAVRLIKLIQRQTWKSDQFLAGHHKGTTCVRAMPRCAAVGSRDKSISIWVFPGTLKPLFVINNI-------FNHTVMDFAWCGRNLLACSQDGTVKVIHLSESVIGEMISNEA.......... 359
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.