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Query: [J] KOG0465 Mitochondrial elongation factor, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVQKMMWVPRKMVGGRIPFFTCSKVFSGFSRRSFHESPLARSTYEEEKVLVDEIKQKLTPDDIGRCNKLRNIGISAHIDSGKTTFTERVLYYTKRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATYCSWDKEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGSDPFRAIEQLNSKLKIPAAAVQIPIGSESSLSGVVDLINRVAIYNKGDNGEIIEKGPVPENLKPLMEEKRQLLIETLADVDDEMAEMFLEEKEPTTQQIKDAIRRSTIARSFTPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTALDVSNNEAKVNLVPAVQQPFVGLAFKLEEGKYGQLTYVRVYQGRLRKGNYITNVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFGIDCASGDTFTDGSVQYSMSSMYVPDAVVSLSITPNSKDASNFSKALNRFQKEDPTFRVKFDPESKETIISGMGELHLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLSPVDDITKGNIFETAIVGGRIPDKYLAACGKGFEEVCEKGPLIGHRVLDVKMLINDGAIHAVDSNELSFKTATMSAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNKLQAVIQDTENGHDEFTLKAECALSTMFGFATSLRASTQGKGEFSLEFSHYAPTAPHVQKELISEFQKKQAKKLast
1 -194.000[J] KOG0465 Mitochondrial elongation factor  ali  100  1MSVQKMMWVPRKMVGGRIPFFTCSKVFSGFSRRSFHESPLARSTYEEEKVLVDEIKQKLTPDDIGRCNKLRNIGISAHIDSGKTTFTERVLYYTKRIKAIHEVRGRDNVGAKMDSMDLEREKGITIQSAATYCSWDKEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGSDPFRAIEQLNSKLKIPAAAVQIPIGSESSLSGVVDLINRVAIYNKGDNGEIIEKGPVPENLKPLMEEKRQLLIETLADVDDEMAEMFLEEKEPTTQQIKDAIRRSTIARSFTPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTALDVSNNEAKVNLVPAVQQPFVGLAFKLEEGKYGQLTYVRVYQGRLRKGNYITNVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFGIDCASGDTFTDGSVQYSMSSMYVPDAVVSLSITPNSKDASNFSKALNRFQKEDPTFRVKFDPESKETIISGMGELHLEIYVERMRREYNVDCVTGKPQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLSPVDDITKGNIFETAIVGGRIPDKYLAACGKGFEEVCEKGPLIGHRVLDVKMLINDGAIHAVDSNELSFKTATMSAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNKLQAVIQDTENGHDEFTLKAECALSTMFGFATSLRASTQGKGEFSLEFSHYAPTAPHVQKELISEFQKKQAKK 761
2 -173.000[J] COG0480 Translation elongation factors (GTPases)  ali follow..  43  2.............................................................ARINPLEKVRNIGIAAHIDAGKTTTTERILFYSGIIHKIGEVHEGTAV---TDWMDQERERGITITAAAISTSW----KDYQINIIDTPGHVDFTIEVERSMRVLDGVIAVFCSVGGVQPQSETVWRQADRYKVPRIAFINKMDRTGANFYRVHEQMRDRLRANAIAIQLPIGSENDFKGIVDLVRKRAYMYNNDQGTDIEETDIPADLQDQVEEYYTKLVEAVAETDDDLMSKYFDGEPLTEEEIRSALRKGTIAGTIVPVLCGSAFKNKGVQLMLDAVVDYLPAPTEVPPIQGTLPNGDA-IERRADDNEPLAALAFKIMADPYGRLTFVRVYSGVLKKGSYVLNATKNKKERISRLVLMKADDRQDVEELRAGDLGAALGLKDTTGDTITDEGAPVILESLFIPEPVISVAVEPKTKDMDKLSKALQSLSEEDPTFRVNVDPETNQTVIAGMGELHLEILVDRMLREFKVEANVGAPQVAYRETIRKPVTVEGKFIRQSGGKGQYGHVVINLEPGEP-GTGFEFVSKIVGGVVPKEYIGPAEQGMKESCESGILAGYPLIDVKATLVHGSYHDVDSSEMAFKIAGSMALKEAVLKASPVLLEPMMKVEVEVPEDYIGNVIGDLISRRGQIESQSTEQGLAKVASKVPLATMFGYATDIRSKTQGRGIFTMEFSHYEEVPRSVAETIIAKSKGNA... 692
3 -128.000[J] KOG0469 Elongation factor 2  ali follow..  22  13...............................................................MDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIA--GSKAGETRF---TDTRKDEQERCITIKSTAISLFFEEKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEELFQTFQINVIIATYGDDDGPMGPIMVDPSIGNVGFGSGLHGWAFTLKQFAEMYAGKFGVQVDKLMKNLQFVLDPIFMVFDAVMNIKKDKTAALVEKLGIKEGKPLMKVFMRKWLPAGDTMLQMIAFHLPSPVTAQKYRMDDEAAVAIKTCDPNGPLMMYISKMVPTSDKGRFYAFGRVFSGKVATGMKARKKEDLYEKTIQRTILMMGRFIEPIEDIPSGNIAGLVGVDQYGGTITTYKDAHNMRVMKFSVSPVVRVAVEAKNADLPKLVEGLKRLAKSDPMVQCIFE-ESGEHIIAGAGELHLEICLKDLEEDHAIPLKKSDPVVSYRETVQSESNQICLSKSPNKHNRLHCTAQPMPDGLPDGTGPNLLMDVTKGVQYLNEIKDSVVAGFQWATREGVLSDENMRGVRFNVHDVTLHAIHRGGGQIIPTARRVFYASVLTAEPRLLEPVYLVEIQCPEAAVGGIYGVLNRRRGHVFEESQVTGTFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPLEAGTKPNQIVLDTR 833
4 -119.000[J] KOG0468 U5 snRNP-specific protein  ali follow..  18  127.................................................................TPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFETMEERQ----LRYTDTLFTEQERGCSIKATPVTLVLQVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFASSNSKTRKFSKKQPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDSGFVDMCVEHIKSPLENAKRKVDHEGDIYRDMISCNQYGTLMVHSSKMNDDCTFFQVLARIVSGTLHAGQEVRDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDSTIVDINVPEDLYIFRPLKFNTQSIIKIAVEPVNSELPKMLDGLRKVNKSYPLLSTRVE-ESGEHVILGTGELYLDCVMHDLRKMYEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDRSIWAFGPDSTGPNILTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGGQITARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIIRPLEPQQA 929
5 -109.000[J] COG4108 Peptide chain release factor RF-3  ali follow..  23  1.......................................................MLMSTTPYFGEVSKRRTFAIISHPDAGKTTITEKVLLFGRAIQVAGTVKGGSNQHAKSDWMEMEKERGISVTTSVMQFPY----GDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRDTPIVTFMNKLDREIRDPMELMDEVENELKIACSPITWPIGCGKEFKGVYHIHRDETILYTSGQGHTIQEERIIK---------GLDNPELDQAVGADLAAQLREELELVLGASHEFDRELFLQGELTPVFFGTALGNFGVDHMLDGLTQWAPSPMPRQAA-------ERVVEASEEKFTGFVFKIQAMDPKHRDRIAFVRIVSGTYKQGMKMNHVRLGKQVNISDAVTFMAGDRARAEEAFAGDIIGLHNHGTIQIGDTFTQGETLKFTGIPNFAPELFRRIRLRDPKQKQLLKGLVQL-SEEGAVQVFRPLQNNDLIVGAVGVLQFDVVVSRLKSEYNVEAIYEGVNVATAECDDVKKFEEFKRKNQSNLALDGGDNLAYIAPTMV-NLNLAQER........................................................................................................................................................................... 519
6 -89.100[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  20  2..................................................................IENLRNIAIIAHVDHGKTTLVDKLLKLSGTLDR-----KEAESERVMDSNDQEKERGITILAKNTAIKW----NGYNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQDGPMPQTRFVTQKAFKAGLRPIVVVNKIDRPGARPDWVIDQIFDNLGATDEQLDFPIVYASALNGIAGLDHEKMDDN--------------------------------------------------------------------------------MDALFQAIIDHVPAP-------------------VVDTEGPFQMQISQLYNSFLGVIGIGRITRGKVKSNTPVVAISDDGSGRILKIMGHHGLQRVEVAEAEAGDIVCVSGMEELISDTLCDPQNVEALPPLTVDQPTVSMTFQVKFVTSRNIKERLEKELLHNVALRVEPGDSPEKFKVSGRGELHLSVLIETMRREG-FELAVGRPEVVIIEKDGEKQEPYENVTIDI--EEQHQGSVMEQMGLRKGDIPDGKGRVRLEYTIPARGLIGFRNNFLTLTSGTGILTSTFSHYGPIKAGEVSNRQNGVLVSMATGTALTYLETLQSRGKLFLGPGDEI-------YEGQLAG-INSRDNDLVINPTKG-KKLDNMRASGKDEVIALVPPIRFTLEQALEFIADDELVEVTPKLRKKMLNENDRKRYER 602
7 -83.600[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  20  20...............................................KHYSTAGDPTKLVNLSEFTPDKIRNFGIVAHVDHGKSTLADRLLEMCGAVPPGQK--------QMLDKLQVERERGITVKAQTAALRH----RGYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQGVQAQTIANFWLAFEKNIQIIPVINKIDLPGADIKSVETQLKNLFEFNPEECLHI----------------------------------------------------------------------------------------------SAKSGLNVDKVLEAIIDRVPAP-------------------TAIIDAPFRSMIFDSFDHFRGAIAHIMVKEGSVKKGDKIQSYQNEKVYDVSEVGVMRPEKCTELRAGQVGYLVCNMR-EAVVGETLFAETTSKTFAEIKGVKPTVYAGLFPETSDYESLKQAVERLCLNDPSVTVIPDSSKALGRIGFLGVLHMEVFGARLSQEYDASVILCQPSVEYRAKIKDNETIRKKRYDGMEEIRILDPSKF---PDESDVDSFLEPMVKVRMIVPNEMMGTVNGLCSECRGERGEITSIDSTRLVILWRLPLAEVAVERLKKLTSGYASFDYEPDGWQDTRLVKLTILINSKEVSEFSQIIPAMARDRAKILVQRLKREIPRQQFEVTIKACIGSSTKAIVIQPMKRDFSQLLKGN---GMERLNKKLSHQKKGKER. 625
8 -71.200[M] COG0481 Membrane GTPase LepA  ali follow..  27  1..................................................................MKNIRNFSIIAHIDHGKSTLSDRLIQTCGG------LSDREMEAQVLDSMDLERERGITIKAQSVTLNYKAKDETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMNLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRC----------------------------------------------------------------------------------------------SAKTGVGIEDVLEEIVHKIPAP-------------------EGDPNAPLQALIIDSFDNYLGVVSLVRIKNGTLRKGDKIKVMSTGQSYNVDRLGIFTPKQTILNCGEVGWVVCAIKDILGAPGDTLTSHNNPSVLPGFKKVKPQVYAGLFPSSDDYEAFRDALGKLSLNDASLFYEPENSTAGFRCGFLGLLHMEIIQERLEREYDLDLITTAPTVVYEVEKTDGEVIYVDSPSKLPPLNNITE--------------------------------------------------------------------------------------------IREPIAECNMLLPQTYLGNVITLCVEKRGVQTNMVYHGNQVALTYEIPMGEVLDFFDRLKSTSRGYASLDYGFKRFQAADMVRVDIMIN......... 488
9 -22.000[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  19  19.............................................................MIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYF----STEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVINKMDLVDYSFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPWYSG----------------------PTLLEVL--------ETVEIQRVVDAQPMRFPVQYVNRPNLDFRGYAG-------------------------------------------------------------------TLASGRVEVGQRVKVLPSGVESNVARIVT----FDGDREEAFAGEAITLVEIDISRGDLLLAADEALPAVQSASVDVVWMAEQPLSPGQSYDIKIAGKKTRARVDGIRYQVDINNLTLPLNGIGLVDLTFDEPLVLDRYQQNPVTGGLIFIDRLS..................................................................................................................................................................................................................... 425
10 -21.700[J] KOG0458 Elongation factor 1 alpha  ali follow..  13  143.............................................YKTTVPTKPKKPHDISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVETMGK--SSFKFAWIMDQTNEERERGVTVSICTSHF----STHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNADGQTKEHMLLASSLGIHNLIIMNKMDNVDWS-QQRFEEIKSKL-----------------------------------------------------------------------LPYLVDIGFFEDNI-----------NWVPI---SGFSGEGVPNLMSTLENAAFKISK----------ENEGINKDDPFLFSVLEIIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSEQSCIVDKIQVGSQQGQEETDVAIKGDLRKAYPEDIQNGDLAASVDYSSIHSAQCFVLELTTFDMNRPLLPGTPFILFIGVKEQP-KRLISFIDKGNTASHLGSKQRAFVEIELIEVKRWIPLLTAHENDRLG......................................................................................................................................................................................................................... 590
11 -21.400[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  14  183........................................................................VTIMGHVDHGKTTLLDKF--------RKTQVAAVET--------------GITQHIGAFLVS----PSGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKVKKELLAY-------------VCEDYGGDVQAVPV------------------------------------------------------------------------------SALTGDNLMALAEATV------------------LAEMLELKADPNGPVEGTVIESTDKGRGLVTTAIIQRGTLRKGSVLVAGKC------AKVRLMFDENGKTIDEAYPSMPVGITGWRDLAGEEILEVESEPRAREV--------VDWRKYEQEQEKGQEDLKIIEEKRKEHKEAHQKAREKYGHLLWKKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIK------------------GDVDGSVEAILNIIDTYDASHECELELVHFGVGDISANDVNLAETFDGV----IYGFNVNAGNVIQQSAAKKGVKIKLHKII-LVEDLQEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQKKFSLTSLKHHKDDISIVKTG................................. 689
12 -21.000[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  20  55.......................................................................NIGTIGHVDHGKTTLTAAITKCLSDLGQ-----ASFMDYSQIDKAPEEKARGITISSAHVEYE----TANRHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQMPQTREHLLLARQVGVKQVVYINKVDMVEPDMIELVE----------------------------------------------------------------------------------------MEMRELLSEYGFDGDNTPIVSGSALCALSITKLMEAVDSYITLPER-------------------KTDVPFLMAIEDVFSSGRGTVVTGRVERGTLKKGAEIEIVGYGSHLKTT--VTGIEMFKKQLDAAVAGDLRSIKREQLKRGMIVAQPGTVAPHQKFKASFYILTKEEGGRRTGFVDKYRPQLYSRTSDVTVELTHDPNDSDKMVMPGDNVEMICTLIH.......................................................................................................................................................................................................................................... 410
13 -20.200[J] KOG0459 Polypeptide release factor 3  ali follow..  15  93.............................................................VAEANKKRHLNVVFIGHVDAGKSTIGGQILFLSGQVRQIQKYEKEAKMAYIMDTNEEERLKGKTVEVGRAHF----ETESTRFTILDAPGHKSYVPNMISGASQADIGVLVISARKGEGGQTREHVQLAKTLGVSKLIVVNKMDDPTVNWSKEYDEIEQKMVPFLKASGYNTKKDVVF--------------------------LPISGLMGKNMDQRMGQEICPWWSGPSFFEVLDSIEIPPRDPNGPFRMPIID-----KFKDMGTVVMG------------------------------------------------------------KVESGSIREGDSLVVMPNKEQVKVVAIYC----DEDKVKRAGPGEITGIEDEDILSGFVLSSIVNPVPAVT-EFVAQLQILELLDNAIFTAGYKAILHIHAVVEECLKSQIDLKTRKPM-GAAVVCRIQVTNSICIEKFSDFPQLGR............................................................................................................................................................................................................................. 507
14 -20.000[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  43.......................................................................NIGTIGHVAHGKSTVVKAI---SGVHTVKNELERNITIKLQLDDPSCPRPECYRSCGSSMPDEFPTDRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCQPQTSEHLAAIEIMKLKHLILQNKIDLVKERQAKEQY----------------------------------------------------------------------------------------EQILAFVQGTVAEG--APIIPISAQLKYNIEVVCEYIVKKIPVP----------PRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQETEEGKLMCKSIFSKIVSLFAEH-NDLQYAAPGGLIGVCRADRMVGQILGAVGALPIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVL.............................................................................................................................................................................................................................................. 429
15 -19.200[J] COG0050 GTPases - translation elongation factors  ali follow..  19  14.......................................................................NVGTIGHVDHGKTTLTAAITTVLAKTYG-----GSARAFDQIDNAPEEKARGITINTSHVEYD----TPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIVFMNKCDMVD--------------------------------------------------------------------------------DEELLELV-------EMEVRELLSAYDFPGDDLPVVRGSALKALKIIELAGYLDSYIPEPE------------------RAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVVGIKDTVKSTCTGVEM----FRKLLDEGRAGELRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGDNINMIVTL.............................................................................................................................................................................................................................................. 363
16 -18.900[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  17  3.................................................................KEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIRTIEKFEKEAQYAWVLDKLKAERERGITIDIALWKF----ETAKYYITIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGENGQTREHALLAQTLGVKQLIVCNKMDSTEPPFSE-------------------------------------------------------ARFTEITNEVSGFIKKIGYNPKAV--PFVPISGFNGDNMLEVSSNMPWFKGWAVERKEGNASGKTLLEALDSI----------------------IPPQRPTDRPLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPQNVTTEVKSVEM----HHESLPEAVPGDVKNVSVKDIRRGSVCSDSKQDPAKEARTFHAQVIIMNHPGQDCHTAHIACKFNELKEKDRRTGKKVEDFPKFLKSGDAGIVELIPTKPLCVESFTDYAPLGRFAVR-RQTVAVGVIKSVEKSDGSSGK................................................................................................................................................................................................... 450
17 -18.500[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  18  3..............................................................IMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIHIIEEYRKEAEFAWVMDRFKEERERGVTIDLAHRKF----ETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGVMEQTREHAFLARTLGVPQMVVINKMDATSPPYSERYNEVKADA--------------EKLLRSIGFKDISFVPISGYKGDNVTKPS-----------------PNMPWYKGPTLLQALDAFKVPEKPINKPLR--------IPV---------------------------------------------------------VYSITGIGTVPVGRVETGVLKPGDKVIFLPADKQGDVKSIEM----HHEPLQQAEPGDVRGIAKNDIKRGDVCGHLDTPPTVVKLNHPSVIAPGYKPVFHVHTAQVACRIDEIVKTNPKDGTTLKEKPDFIKNGDVAIVKVIPDKPLVIEKVSEIPQLGRFAVRDMGQTVAAGQCIDLEKR........................................................................................................................................................................................................ 427
18 -18.100[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  12  3........................................................................IVTSGHVDHGKTALLKAL------------------TGTSTAHLPEEKKRGMTIDLGYAYLP-----ENKVLGFIDVPGHEKFLSNMLAGLGGVHYAMLIVAADEGVAVQTKEHLAILRQLQFHEIVVITKADR---------------------------------------------------------------------------------TNSAQIES-----------LIQTIKQDYSFLRNANYFVTSAETGQGISELRHYLANLAEL--------------------ADTQKPFRYAIDRVFSVKGAGTVVTGTAFSGTVKVNDEIY-LSTGQKIRIKAIHA----QNTSSEQGIAGQRLALNLNADLDRTPM-------------------------KRGDWLLQNEPLPPTDRISVQILAEVPLNESQPVHIYHGASRTTGKLTLLQGKNAAKNDRTLAEIILDSPLFLAFGDKLILRSGDTKTLIAGARVLEINSPKRHKRTEVRLNF-----LANLALAENASQRIALTLQHNATTARQLMWTEQLTSLQLDKALAERDAVRYQDWCFNPNYVQEKTQQILTALNIYHEQHNDQ-LGVSKARLYRMATLNQPIDEMLDDGRLQQTRGWIHLPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWVRDMANALAIDESI. 528
19 -17.800[R] COG5258 GTPase  ali follow..  12  109.......................................................................TVVALGNVDAGKSTLVGVLTT--------GRLDDGKGLASYASRYKHEVLTGRTSAVSLRLLGFSGKRSDKLVLLVDVGGHERYLRTALRGLSQPDYVMLVVAANSGVQKMTKEHLGIAVAIGIPVFVVVTRIDITPSEFQKTVEEVVRILKMPGV---------------------------------------------------SKIPYIIKDTNDVVLAA-----------------KAMPAGRVAPVFYVSSVTGHGLDLLLRFLSLLPRRR-------------------RWDYGGEFLMYISDIYLKGVGVVIGGLVEKGILHVGDRVWLGPYSDGKWMQTVVKSIHFNRTPVESAKAGSFITLDKVEKVEKGMVLSARPLKAVREVTADVLVLRHPTVIRAGFSGVFDSGVVKIELSRPWHIDSGVFVFRNGPTRILGRI.................................................................................................................................................................................................................................................. 508
20 -17.700[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  17  448........................................................................VTIMGHVDHGKTTLLDRF--------RESRVTEGEA--------------GITQHIGA----YQIKANGKKITFLDTPGHEAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAAGVPIIVAINKIDKPGANPQRVTQELTEH--------------------------------------------------------------------GVFPVAWDPENGSEFVEI-------------------SAKFNQNLDELLDTVL------------------VAEVQELKADPTVRAIGTVVEALDQGKGAIATLLVQQGTLHVQDPIV-----VGNTYGRVRTMTNDLGRRIKEAGPSTPIELTGLS-------------------DVPQAGDHFAVFEDEKAARAAGE--------------ERAKRAQLIKRQNTRRVNLDNLFDTLKEG-----QTKSVNIIIKADVQGSAEA----------------LAASLQKIEVEGVKVDIVHSAVGAISESDISLA-------AASNAIIIGFNVEEVDIRLHSIIYKVIEEVETAMR-----------------MLDPEFK-EEIIGEAIVRETFN---SKVGTIAGFMVIRGKVARDASVAIASLKHFKDDVKEVGNA--EGGLMVEDFNDVEIDDTFEVYKMVEIERK.. 944
21 -17.200[E] COG4917 Ethanolamine utilization protein  ali follow..  16  1.....................................................................MKRIAFVGSVGAGKTTLFNALQGNYTLARKTQAVE-------------------------------------NDKGDIDTPGHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIG--VSKRQIAVISKTDMPDADVAATRKLLLE-TGFEEPMFELNSHDPQSVQQLVDYLASLT............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 146
22 -16.900[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  17  8.......................................................................NIGLVGHVDHGKTTLTKAL------------------SGVWTDTHSEETKRGISIRLGYADIT-TETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCQPQTKEHLMALDVIGVKDIVVQNKID------------------------------------IVS---------------------------------KERALESYREIKEFVKGTCAED---------------------APIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDINKPGAD----------PEHLAGGVIGGSLVQGRLRVGDEI-KDGKQTWMSLHSTITGLVAGGEEMEEVGPGGLVGVG--------------------------------------------------TLLDPA--LTKADSLSGSVAGEPGTLSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADDADVVLKLPACAEEGQRIALSRRIGYGII.................................................................................................................................................................... 407
23 -14.600[R] COG2229 Predicted GTPase  ali follow..  17  5.......................................................................KIIFTGPVGVGKTTAIAAILVQTDASASDMTLDRKRNTTVAMDYGAISLDEDT------------------KVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFR-KAPVVVGITKMDIRSQPGIDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSI............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 172
24 -13.800[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  15  53...................................................................TKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEPNEGTFVLHNENN------------------TKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALE-IRAASEYLYDSVIKNKTPVLLCCNKTDKVTA---------------------------------------------------HTKEFIRKQMEKEIDKLRVSRSAISTADIANDFTLGIEGEVFSFSHCHNKVT-----------VAEASGLTGETDQVQEFIREHV-KP............................................................................................................................................................................................................................................................................................................................................................................................................................. 260
25 -13.600[R] KOG2486 Predicted GTPase  ali follow..  15  122........................................................KSSVKTEDCPADGLPEFALVGRSNVGKSSLLNSLV------KRLALTSKKPGKTQCINHFRI----------------------NDKWYLVDLPGY-KFTKDYFLNRSTLVSVFLLVDASIPVKPIDLEYASWLGQNQVPMTLIFTKCDKRKKK-----------------------------------------------------------------KNGGKKPEANIKEFQDLIQGFFET--------------------TPPWIMTSSVTNQGRDEILLHMAQLRNY.............................................................................................................................................................................................................................................................................................................................................................................................................................. 314
26 -12.900[R] COG0218 Predicted GTPase  ali follow..  14  12........................................................LSAANKSHYPQDELPEIALAGRSNVGKSSFINTML------KNLARTSGKPGKTQLLNFFNIDDK----------------------MRFVDVPGY-CMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKPRGKWNKHESAIKKKLNFDPSDDFILFSSVSK-AGMDEAWD.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 189
27 -12.800[R] COG3596 Predicted GTPase  ali follow..  14  40.......................................................................VIGIMGKTGAGKSSLCNALF--------------AGEVSPVSDVAACTRDP----------LRFRLQIGEHFMTIVDLPGVGEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVEAYRHKMLFVISQSDKQKQNISRKICLLHELFQPVHPVCAVSVRLQWGLRVMAERMIKCL---REPSSPVVALLQHPFRTWVAREQARDDFGETVDTILDTVSTFPLIPAPV--RTIIQAVRSSVVS............................................................................................................................................................................................................................................................................................................................................................................................................................................................ 279
28 -11.100[R] KOG0395 Ras-related GTPase  ali follow..  2....................................................MKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQYTPTIEDFHRKVYNIR------------------------GDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKKEAAELPMVICGNKNDHGELCRQVPTTEAELLVSGD-VSAKKNTNVDEMFYVLFSMAKLP................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 193
29 -10.600[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  15  1..........................................................MSAPAANGEVPTFKLVLVGDGGTGKTTFVKRHL------------------------GEFEKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWRDLVRVNIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISAKYNFEKPFLWLAKLAGNPQLEFVASPALAPPEVQVDEQLMQQYQQEMEQATALPLPDEDD...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 216
30 -10.400[R] COG1160 Predicted GTPases  ali follow..  11  2....................................................................ATPVVALVGRPNVGKSTLFNRLT--------------RTRDALVAD------FPGLTRDRKYGHAHI----AGYDFIVIDTGGEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLQRQNKITVVVANKTDGIDADSHCAEFYQLGLGEIEQIAASQGRGVTQLMEQVLAPFAEKMENADENDRTSEEEQDEWEQEFDFDSEEDTALIDDALDEELEEEQDIVGRPNVGKSTLTNRILGE--DRVVVFDMPGTTRDSIYIPMERDGQQYTLIDTAGVRKRGKVHLAVEKFSVIKTLQAIQDANVVLLTIDARENISDQDLSLLGFILNAGRVIVVNKWDGLDQDVKDRVKSELDRRLDFIDFARVHFISALHGSGVGNLFDSIKEAYACTQKMTTSLLTRILQPMIGGRRIKLKYAHPGGYNPPIIVVHGNQM------DKLPDSYKRYLSNYYRKSLKIRLLFQEGSNPFAGRKNKLTPNQLRKRKRL...................................................................................................................................................................................................... 495
31 -10.400[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  17  18...................................................................QKEAKILFLGLDNAGKTTLLHML-----------KDERLVQHQPTQHPTSEELSIG-----------------KIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAYD-SKRELDALLSDEALATVPFLILGNKIDIPYA----SEDELRYHLGLTNF...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 151
32 -10.400[P] COG0370 Fe2+ transport system protein B  ali follow..  13  5.......................................................................TYCILGNPNTGKTSLFNAL---TGSYEYVGN--------------------GVTVEKK------VGTLRSKTGKLIDLPGIYDLNPISRDETVVTDCMLNIVDSSQ---ERNLNLTVQLLEYGAPVVMGLNMIDVAAGRGIHLIQNLAKKLRIPILPV-----VARSGKGTEDIL--STLSEKHVAPAIPLVLQYGEPAEKAIKEIQALTKELIPAKQSRLAIQFLSKNEVTEAFLTSNSAFEQLQQIRAEL-LNGKLENHFHQVRASYIHDICLTSVEYTRNSDIPLSDK---------------LDKIFTHKLLGIPIFLGIMWLIFQITFTWVGAPLSDMLDGFIGGSLTDWVTSFLTTIGASGF-----IIDLVADGIIAGVGGVLVFVPQILVIFFFISVLEDSGYMARIAVVMDRVME-----IFGLNGKAFIPMIIGFG---IEESKERTLTILVSPFMSCSARLPFVGVFFEKHQALVVLSLYVIGILMALIVTKILSKTILKKDNSVFVVE-----LPPYRLPSLKTLWRSTWEKG--AGTFIFAGSVIIWLLNYAGPSGLDVPMGESFLAIIGGM--------LAPLLVPLGFGTWQAGATLIPGFLAKEVVVSTMAIIYAVGESSLGSIVSTFYTPLSAYCFML................................... 613
33 -10.400[R] COG1159 GTPase  ali follow..  14  11........................................................................IAIVGRPNVGKSTLLNKLL--------------GQKISITSRKAQTTRHRIVGIHTE----------GPYQAIYVDTPG---MNKAASSSIGDVELVIFVVEGTRWTP-DDEMVLNKLRDGKAPVILAVNKVDQEKVDLLPHLQFLASQMNFLDI-VPISAETGMNVDTIAGIVRKHLHHFPEDYITDRSQRFMASEIIR--EKLMRFLGAELPYSVTVEIERFVTNERGGYDINGLILVEREGQKKMVIGNKGAKIKTIGIEARKD...................................................................................................................................................................................................................................................................................................................................................................................................................................... 264
34 -10.200[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  18  22.......................................................................ELTLVGLQFSGKTTFVNVI--------ASGQF---EDMIPTVGFNMRKITRG-----------------NVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDAAD-SRNELHSLLDKPQLAGIPVLVLGNKRDLPGA----DETGLIERMNLSSI...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 152
35 -9.860[R] COG1084 Predicted GTPase  ali follow..  16  160...................................................................LDAFTVVIAGFPNVGKSTLLRTL---TGAEPEVADY--FTTKGIQIGHLERK---------------------WKRIQVIDTPGLLDRPVEMVALENIADVIMFIFDASETCESQYSLYLGIRSVFDIPVVTVFNKMDLAENV-----KYLEEYINMVEDPLKVSAFEGRGVSKIIKKL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 321
36 -9.820[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  15  14...................................................................ERELRLLMLGLDNAGKTTILKKF-----------NGEDIDTISPTLGFNIKTLE-----------------HRGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSAD-CQRELQSLLVEERLAGATLLIFANKQDLPGA---LSSNAIREALELDSI...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 147
37 -9.800[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  12  15...................................................................DQEVRILLLGLDNAGKTTLLKQL-----------ASEDISHITPTQGFNIKSVQ-----------------SQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSAD-TGQELAELLEEEKLSCVPVLIFANKQDLLTA---APASEIAEGLNLHTI...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 148
38 -9.720[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  17  15...................................................................SREMRILILGLDGAGKTTILYRL-----------QVGEVVTTIPTIGFNVEQVT-----------------YKNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSAD-SKDELLYMLREEELAGAILVVLANKQDMDGC---MTVAEVHHALGLENL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 148
39 -9.670[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  15  19.......................................................................RILMVGLDAAGKTTILYKL-----------KLGEIVTTIPTIGFNVETVE-----------------YKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSND-ARDELHRMLNEDELRDAVLLVFANKQDLPNA---MNAAEITDKLGLHSL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 148
40 -9.670[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  16  19...................................................................NKEMRILMLGLDAAGKTTILYKL-----------KLNQSVVTIPTVGFNVETVT-----------------YKNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSAD-ARQELHRIISDREMRDCLLLVLANKQDLPGA---LSPAQITDVLQLDKL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 152
41 -9.580[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  16  16...................................................................NKELRILILGLDGAGKTTILYRL-----------QIGEVVTTKPTIGFNVETLS-----------------YKNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSTD-ASKELHLMLQEEELQDAALLVFANKQDQPGA---LSASEVSKELNLVEL...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 149
42 -9.530[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  14  3..........................................................MGVGDSSGSPKPIRIVVVGEKGSGKSSLIMAAA-------------------------RNTFHPNIPSLLPYTNLPSEFFPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFAFDR---DRLSKYWLPLFRQRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVETSI-SAQRLDQAKDVLYYAQ------KAVIDPVGPVFDQENNVLKPRCIAALKRIFLLSDHNMDGILSDEELN---------------ELQKKCFDTPLVPCEIKQMKNVMQVTFPQGVNERGLTLDGFLFLNTRLIEEARIQTLWTMLRKF-------------YSNDLRLGDDLVPYSS---------FKRQADQSVELTNVAIEFLREVYEFFDSNGDNNLEPHEMGYLFETAPESPWTKPLYKDVTEENMDGGLSLEAFLSL--SLMTLIDPPRSLEYLMYIRPSDDPSSAVRVTRKRVLDRKEKKSE---RKVVQCFVFGPKNAGKSA--GRSYDDDSNNNNGSTDEHYAVNMVKEPGVISDTDKTLVLKEVRIKDDGFMLSKEALAACDVAIFIYDS------SDEYSWNRAVDMLAEVATIAKDSGYVFPCLMVAAK----------TDLDPFPVAIQESTRVTQDIGIDAPIPISSKLGDVSNL....................................... 589
43 -9.480[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  10  1..................................................................MKRPLIIGVGGPVGAGKTMLIERLTYLSTKGYSMAAITNDIYTKEDARILLNTSVLPADRIAGVET-EMCDKHPDLQLLFLESGGDNLSATFSPD---LVDFSIYIIDVAQGEKIPR----KGGQGMIKSDLFIINKVDLAPY---EVMKADTLKSRGNKDFFVTNLKTDEGLKSVADWIEKRL............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 199
44 -9.430[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  11  77.......................................................................KVAFFGRTSSGKSSVINAML-IGHITNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKDDLVLVDSPGTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNEWLSKPNIFINRWDASASEPEYMEDVRRQHMQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTAKQILATVKNIMDSVNLAAEDKRHYSVEERED................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 375
45 -9.370[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  18  95........................................................................ILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNAL-VVDAKKQFRALSG-ESVTIVDTPGILDFTGVLEWFAERVDRIILLFDAHKDISDEFKRCIEALAGNEDKIRIVLNKSDMDHQQLMRVYGALMWSLGKVFKTPEVS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 284
46 -9.370[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  14  19.......................................................................SILILGLDNAGKTTFLETL-----KKEYSLAFKALEKIQPTVGQNVATIPVD----------------SKQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSSD-CSTTLQSVVMDEEIEGVPILMLANKQDRQDR---MEVQDIKEVFNKIAEHIS................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 158
47 -9.140[R] KOG0394 Ras-related GTPase  ali follow..  17  6...................................................................RTLLKVIILGDSGVGKTSLMNQYV---------KKFSNQYKATIGADFLTKEVQ----------------EDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWRESDPENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCASKGNIPYFETSAKVGTNVEEAFQCIA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 173

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.