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Query: [J] KOG0469 Elongation factor 2, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVNFTVDEIRALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETRFTDTRKDEQERCITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEELFQTFQRIVENINVIIATYGDDDGPMGPIMVDPSIGNVGFGSGLHGWAFTLKQFAEMYAGKFGVQVDKLMKNLWGDRFFDLKTKKWSSTQTDESKRGFCQFVLDPIFMVFDAVMNIKKDKTAALVEKLGIKLANDEKDLEGKPLMKVFMRKWLPAGDTMLQMIAFHLPSPVTAQKYRMEMLYEGPHDDEAAVAIKTCDPNGPLMMYISKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYVPGKKEDLYEKTIQRTILMMGRFIEPIEDIPSGNIAGLVGVDQYLVKGGTITTYKDAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIFEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVQSESNQICLSKSPNKHNRLHCTAQPMPDGLADDIEGGTVNARDEFKARAKILAEKYEYDVTEARKIWCFGPDGTGPNLLMDVTKGVQYLNEIKDSVVAGFQWATREGVLSDENMRGVRFNVHDVTLHADAIHRGGGQIIPTARRVFYASVLTAEPRLLEPVYLVEIQCPEAAVGGIYGVLNRRRGHVFEESQVTGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPLEAGTKPNQIVLDTRKRKGLKEGVPALDNYLDKMLast
1 -257.000[J] KOG0469 Elongation factor 2  ali  100  1MVNFTVDEIRALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIAGSKAGETRFTDTRKDEQERCITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYNGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPVLFMNKMDRALLELQLGAEELFQTFQRIVENINVIIATYGDDDGPMGPIMVDPSIGNVGFGSGLHGWAFTLKQFAEMYAGKFGVQVDKLMKNLWGDRFFDLKTKKWSSTQTDESKRGFCQFVLDPIFMVFDAVMNIKKDKTAALVEKLGIKLANDEKDLEGKPLMKVFMRKWLPAGDTMLQMIAFHLPSPVTAQKYRMEMLYEGPHDDEAAVAIKTCDPNGPLMMYISKMVPTSDKGRFYAFGRVFSGKVATGMKARIQGPNYVPGKKEDLYEKTIQRTILMMGRFIEPIEDIPSGNIAGLVGVDQYLVKGGTITTYKDAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIFEESGEHIIAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETVQSESNQICLSKSPNKHNRLHCTAQPMPDGLADDIEGGTVNARDEFKARAKILAEKYEYDVTEARKIWCFGPDGTGPNLLMDVTKGVQYLNEIKDSVVAGFQWATREGVLSDENMRGVRFNVHDVTLHADAIHRGGGQIIPTARRVFYASVLTAEPRLLEPVYLVEIQCPEAAVGGIYGVLNRRRGHVFEESQVTGTPMFVVKAYLPVNESFGFTADLRSNTGGQAFPQCVFDHWQVLPGDPLEAGTKPNQIVLDTRKRKGLKEGVPALDNYLDKM 852
2 -227.000[J] KOG0468 U5 snRNP-specific protein  ali follow..  36  113ETTYDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIRQTHPQFEMEERQLRYTDTLFTEQERGCSIKATPVTLVLQ-----------------------DVKQKSYLLNIFDTPGHVNFSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAITVCINKIDRLILELKLPPQDAYFKLKHIVEEVNGLLSTY---GAPDDNLLVSPILGNVCFASSLYGFCFTLKSFAKLYADTYEVAYLDFAKRLWGDMYFNSKTRKFSKKPHNSAQRSFVEFILEPMYKLIAQVVGDVDTTLSDTLAELNVRVSKEEMKSNIRPLLRLVCNRFMGDCSGFVDMCVEHIKSPLENAKRKVDHIYTGPKEGDIYRDMISCNQYGTLMVHSSKMYPNDDCTFFQVLARIVSGTLHAGQEVRVLGENYTLQDEEDSRILQVGRLWVFESRYKVELNRVPAGNWVLIEGIDQCIVKTSTIVDPEDLYIFRPLKFNTQSIIKIAVEPVNPSELPKMLDGLRKVNKSYPLLSTRVEESGEHVILGTGELYLDCVMHDLRKMYSEIDIKVADPVVAFCETVVETSSLKCFAETPNKKNKITMISEPLEKGLAEDIENGTVCINWNKKRIGEFFQVNYDWDLLAARSIWAFGPDSTGPNILVDDTLPSNLLTAVKDSIVQGFQWGTREGPLCEEPIRNVKFKILDGVIANEALHRGGGQIIPTARRVAYSAFLMATPRLMEPYLFVEVQAPADCVSAVYTVLARRRGHVTQDAPVSGSPIYTIKAFIPAIDSFGFETDLRTHTQGQAFCLSVFHHWQIVPGDPLDKSIIAREFMIKTRRRKGLSEDVSINKFFDDPM 960
3 -144.000[J] COG0480 Translation elongation factors (GTPases)  ali follow..  23  1.........MARINPLEKVRNIGIAAHIDAGKTTTTERILFYSGIIHGEVHEGTAVTDWMDQERERGITITAAAISTSWK----------------------------DYQINIIDTPGHVDFTIEVERSMRVLDGVIAVFCSVGGVQPQSETVWRQADRYKVPRIAFINKMDRTGANFYRVHEQMRDRLR-----ANAIAIQLPIGSENDFKGIVDLVRKRAYMYNNDQGTDIEETDIPADLQDQVEEYYTKLVEAV--------------------------AETDDDLMSKYFDGEPLTEEEIRSALRKGTIA--------GTIVPVLCGSAFKNKGVQLMLDAVVDYLPAPTEVPPIQGT---------LPNGDAIERRADDNEPLAALAFKIMADPYGRLTFVRVYSGVLKKGSYVL---------NATKNKKERISRLVLMKADDRQDVEELRAGDLGAALGLKD--TLTGDTITDEGAPVILESLFIPEPVISVAVEPKTKNDMDKLSKALQSLSEEDPTFRVNVDETNQTVIAGMGELHLEILVDRMLREFK-VEANVGAPQVAYRETIRKPVTVEGKFIRQSGGKGQYGHVVINLEPG-----------------------------------------EPGTGFEFVSKIVGGVVPKEYIGPAEQGMKESCESGILAGYPLIDVKATLVHGSYHD--VDSSEMAFKIAGSMALKEAVLKASPVLLEPMMKVEVEVPEDYIGNVIGDLISRRGQIESQSTEQG--LAKVASKVPLATMFGYATDIRSKTQGRGIFTMEFSHYEEVPRSVAETIIAKSK......................... 689
4 -128.000[J] KOG0465 Mitochondrial elongation factor  ali follow..  22  64............IGRCNKLRNIGISAHIDSGKTTFTERVLYYTKRIKHEVRGRDNVMDSMDLEREKGITIQSAATYCSWD------------------------KEGKNYHFNLIDTPGHIDFTIEVERALRVLDGAVLVVCAVSGVQSQTVTVDRQMRRYNVPRVTFINKMDRMGSDPFRAIEQLNSKLK-----IPAAAVQIPIGSESSLSGVVDLINRVAIYNKGDNGEIIEKGPVPENLKPLMEEKRQLLIETL--------------------------ADVDDEMAEMFLEEKEPTTQQIKDAIRRSTIA--------RSFTPVLMGSALANTGIQPVLDAIVDYLPNPSEVLNTAL--------DVSNNEAKVNLVPAVQQPFVGLAFKLEEGKYGQLTYVRVYQGRLRKGNYIT---------NVKTGKKVKVARLVRMHSSEMEDVDEVGSGEICATFGIDCA---SGDTFTDGSVQYSMSSMYVPDAVVSLSITPNS-KDASNFSKALNRFQKEDPTFRVKFDESKETIISGMGELHLEIYVERMRREYN-VDCVTGKPQVSYRESITIPADFDYTHKKQSGGAGQYGRVIGTLSPV----------------------------------------DDITKGNIFETAIVGGRIPDKYLAACGKGFEEVCEKGPLIGHRVLDVKMLINDGAIHA--VDSNELSFKTATMSAFRDAFLRAQPVIMEPIMNVSVTSPNEFQGNVIGLLNKLQAVIQDTENGHDE--FTLKAECALSTMFGFATSLRASTQGKGEFSLEFSHYAPTAPHVQKELISEFQKKQAKK................... 761
5 -91.700[J] COG4108 Peptide chain release factor RF-3  ali follow..  16  6.........TPYFGEVSKRRTFAIISHPDAGKTTITEKVLLFGRAVKGRGSNQHAKSDWMEMEKERGISVTTSVMQFPY----------------------------GDCLVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDAAKGVEDRTRKLMEVTRLRDTPIVTFMNKLDREIRDPMELMDEVENELK-----IACSPITWPIGCGKEFKGVYHIHRDETILYTSGQG-----------------------------------HTIQEERIIKGLDNPELDQAVGADLAAQLREELELVLGASHEFDRELFLQ--------GELTPVFFGTALGNFGVDHMLDGLTQWAPSPMPRQAAE--------------RVVEASEEKFTGFVFKIQANMDPKHRDRIAFVRIVSGTYKQGMKMN---------HVRLGKQVNISDAVTFMAGDRARAEEAFAGDIIGLHNHGTIQIGDTFTQGET---LKFTGIPNFAPELFRRIRLRDPLKQKQLLKGLVQLSEEGAVQVFRPLQNNDLIVGAVGVLQFDVVVSRLKSEYN-VEAIYEGVNVATAECDDVKKFEEFKRKNQSNLALDGGDNLAYIAPTMVNLN................................................................................................................................................................................................................................................ 514
6 -91.600[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  16  3................ENLRNIAIIAHVDHGKTTLVDKLLKLSGTLDRKEAESERVMDSNDQEKERGITILAKNTAIKWN----------------------------GYNINIVDTPGHADFGGEVERVMSMVDSVLLVVDAQDGPMPQTRFVTQKAFKAGLRPIVVVNKIDRPGARPDWVIDQIFDLFDNL--GATDEQLDFPIVYASALNGIAGLDHEKMDDNM------------------------------------------------------------------------------------------------------------------DALFQAIIDHVPAPVV--------------------------DTEGPFQMQISQLDYNSFLGVIGIGRITRGKVKSNTPVVAISDD------GSKRNGRILKIMGHHGLQRVEVAEAEAGDIVCVSGMEE--LFISDTLCDPQNVEALPPLTVDQPTVSMTFREGKFVTSRNIKERLEKELLHNVALRVEPGSPEKFKVSGRGELHLSVLIETMRREGF--ELAVGRPEVVIIEKDGEKQEPYENVTIDIEEQHQGSVMEQMGLRKGDLSNMIPDGKG--------------------------------------RVRLEYTIPARGLIGFRNNFLTLTSGTGILTSTFSHYG-PIKAGEVSNRQNGVLVSMATGTALTYSLETLQSRGKLFLGPGDEI-------YEGQLAGINSRDNDLVIN----PTKGKKLDNMRASGKDEVIALVPPIRFTLEQALEFIADDELVEVTPK---SIRLRKKMLNENDRKR................ 599
7 -83.700[M] COG0481 Membrane GTPase LepA  ali follow..  21  2................KNIRNFSIIAHIDHGKSTLSDRLIQTCGGLSDR-EMEAQVLDSMDLERERGITIKAQSVTLNYK-----------------------AKDGETYQLNFIDTPGHVDFSYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEMNLEVVPILNKIDLPAADPERVAEEIEDIVGIDAMEAVRCSAKTGVG-------------------------------------------------------------------------------------------------------------------------------------IEDVLEEIVHKIPAPEG--------------------------DPNAPLQALIIDSWFDNYLGVVSLVRIKNGTLRKGDKIKVMSTG------QSYNVDRLGIFTPKQVDTTILNCGEVGWVVCAIKDILGAPVGDTLTSHNNPASSVLPGFKKVKPQVYAGLFPISSDDYEAFRDALGKLSLNDASLFYEPENSTGFRCGFLGLLHMEIIQERLEREYD-LDLITTAPTVVYEVEKTDGEVIYVDSPSKLPPLNNITE--------------------------------------------------------------------------------------------------------------------------------------IREPIAECNMLLPQTYLGNVITLCVEKRGVQTNMVYH-GNQVALTYEIPMGEVVLDFFDRLKSTSRGYASLDYGFKRFQAADMVRVDIMINGERV........................ 492
8 -82.200[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  19  38..............TPDKIRNFGIVAHVDHGKSTLADRLLEMCGAVP---PGQKQMLDKLQVERERGITVKAQTAALRHR----------------------------GYLLNLIDTPGHVDFSAEVSRSLAVCDGILLLVAANQGVQAQTIANFWLAFEKNIQIIPVINKIDLPGADIKSVETQLKNLFEFNPEECLHISAKSGLN-------------------------------------------------------------------------------------------------------------------------------------VDKVLEAIIDRVPAPTA--------------------------IIDAPFRSMIFDSYFDHFRGAIAHIMVKEGSVKKGDKIQSYQNE---------KVYDVSEVGVMRPEKCTELRAGQVGYLVCMRTVNEAVVGETLFAETRDSVKTFAEIKGVKPTVYAGLFPVETSDYESLKQAVERLCLNDPSVTVIPDSSKGWRIGFLGVLHMEVFGARLSQEYD-ASVILCQPSVEYRAKIKDNETIRKKRYDGMEEIRILDPSKFPDESDVDSFLEP--------------------------------------------VKVRMIVPNEMMGTVNGLCSECRGERGEITSIDSTRLVILWRLPLAEVAVDFERLKKLTSGYASFDYEPDGWQDTRLVKLTILINSKEVSEFSQIIPAMARDRAKILVQRLKR---IPRQQFEVTIKACIGSSTKAIVIQPMKRDFSQLLKGN---------GMERLNKKLSHQKKGKERMKMVGNVEAFLNVL 643
9 -29.900[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  19  44.........EKVFVRKKPHVNIGTIGHVDHGKTTLTAAITKCLSDLGQASFMDYSQIDKAPEEKARGITISSAHVEY----------------------------ETANRHYAHVDCPGHADYIKNMITGAATMDGAIIVVSATDGQMPQTREHLLLARQVGVKQVVYINKVDMVEPDIELVEMEMRELLSEY----------------------FDGDNTPIVSGSALCALEGREPEIGLN-------------------------------------------------------------------------------------------------SITKLMEAVDSYITLPER--------------------------KTDVPFLMAIEDVFSISGRGTVVTGRVERGTLKKGAEIEIVGYG-------SHLKTTVTGIEM----FKKQLDAAVAGDNCGLRSIKREQLKRGMIVA----------------------QPGTVAPHQKFKASFYILTKEEGGRRTGFVDKYRPQLSRTSDVTVELTHPDPNDDNVEMICTLIHPIV......................................................................................................................................................................................................................................................................................... 413
10 -28.700[J] COG0050 GTPases - translation elongation factors  ali follow..  18  3.........KEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGITINTSHVEY----------------------------DTPARHYAHVDCPGHADYVKNMITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIVFMNKCDMV-----------------------------------------------------------------------------------------------------------------------------DDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAELAGYLDSYIPEPER--------------------------AIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIK-------DTVKSTCTGVEM----FRKLLDEGRAGENVGLRGIKREDIERGQVLAKPGSIKPHTTFESEVYILSKD-EGGRHTPFFKGYRPQFYFRTTDVTGTIELPEGVEMVMPGNINMIVTLIHPIAMDDGLRFAIREGGRTVG........................................................................................................................................................................................................................................................................................ 385
11 -27.700[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  15  27....KLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAI---SGVH----------TVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPTDLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCQPQTSEHLAAIEIMKLKHLILQNKIDLVKER----------QAKEQYEQILAFVQGTVAEG-----------------------------------------------------------------------------------------------------------------------APIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVN---------------------CEVDDLKGGVAGGSILKGVLKVGQETEVRPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTLCRADRMVGQILGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADL---------------GKIVLTNPVCT........................................................................................................................................................................................................................................................................................ 435
12 -26.500[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  20  2..........KIMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRVMDRFKEERERGVTIDLAHRKF----------------------------ETDKYYFTLIDAPGHRDFVKNMITGTSQADAAILVISAREGVMEQTREHAFLARTLGVPQMVVINKMDATSPPYS------EKRYNEVKADAEKLLRSIGFKD-------------SFVPISGYKGDNVTKPSPNMPWYK-----------------------------------------------------------------------------------------------GPTLLQAL-DAFKVPEK--------------------------PINKPLRIPVEDVYSITGIGTVPVGRVETGVLKPGDKVIFLPAD---------KQGDVKSIEM----HHEPLQQAEPGDNIGVRGIAKNDIKRGDVCGHLDTPPTVVKAFTAQIIVLNHPSVIAPGYKPVFHVHTAQVACRIDEIVKTLNKDGTTLKEKPDFIK--------NGDVAIVKVIPDKPLV......................................................................................................................................................................................................................................................................................... 394
13 -26.200[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  19  21............AQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSLHLVDGLQAEREQGITIDVAYRYF----------------------------STEKRKFIIADTPGHEQYTRNMATGASTCELAILLIDARKGVLDQTRRHSFISTLLGIKHLVVINKMDLVDYS--------EETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPW-----------------------------------------------------------------------------------------------------------SGPTLLEVL-ETVEIQRV--------------------------VDAQPMRFPVQYVNRPNLDFRGYAGTLASGRVEVGQRVKVLPSG---------VESNVARIVT----FDGDREEAFAGEAITLVLTDEIDISRGDLLLAADEALPAVQSASVD-VVWMAEQPLSPGQSYDIKIAGKRVDGIRYQVDINNLTQREVENLPLNGI-------------GLVDLTFDEPLV......................................................................................................................................................................................................................................................................................... 405
14 -25.900[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  19  1............MGKEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEVLDKLKAERERGITIDIALWKF----------------------------ETAKYYITIIDAPGHRDFIKNMITGTSQADCAVLVVACGTGENGQTREHALLAQTLGVKQLIVCNKMDSTEPPFS------EARFTEITNEVSGFIKKIG----------YNPKAVPFVPISGFNGDNMLEVSSNMPWFKGWAVERKE--------------------------------------------------------------------------------------SGKTLLEALDSIIPPQRPTDR---------------------------PLRLPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPQN---------VTTEVKSVEM----HHESLPEAVPGDNVGVKNVSVKDIRRGSVCSDSKQDPAKEARTFHAQVIIMNHPGQISNGYTPV------LDCHTAHIACKFNELKEKVDRRTGKKVEDFPKFLKSGDAGIVELIPTKPLC......................................................................................................................................................................................................................................................................................... 411
15 -25.500[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  16  8....................NIGLVGHVDHGKTTLTKAL---SGV-----------TDTHSEETKRGISIRLGYADI--TFRKCPQCEAPMCYTTAEICERCGTETELLRKVSFVDAPGHETLMATMLSGAALMDGAILVIAANEPCQPQTKEHLMALDVIGVKDIVVQNKIDIVSKEALESYREIKEFVKGTCAE-----------------------------------------------------------------------------------------------------------------------------------APIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVARSFDIN---------------------ADPEHLAGGVIGGSLVQGRLRVGDEIEIRPGIQVKKDGKQTWMSLHSTITGLVAGG-EEMEEVGPGGLVGVGALTKADSLSGSVAGEPGT-------------------PPVRHSFTMETHLLERVVGTKEETKVEPIKTGEPLMINVGTTTTVGVVKSARADD--ADVVLKLPACA........................................................................................................................................................................................................................................................................................ 383
16 -24.300[J] KOG0458 Elongation factor 1 alpha  ali follow..  14  153....KPHDISAFVKSALPHLSFVVLGHVDAGKSTLMGRLLYDLNIVNQSQLRKLQIMDQTNEERERGVTVSICTSHF----------------------------STHRANFTIVDAPGHRDFVPNAIMGISQADMAILCVDCSTNA--QTKEHMLLASSLGIHNLIIMNKMDNVDWSQQR--EEIKSKLLPYLVDIG-----------------FFEDNINWVPISGFSGEGVYKIEYTDEVRQWYN---------------------------------------------------------------------------------------------PNLMSTL-ENAAFKISKENEG-----------------INKDDPFLFSVLEIIPSKKTSNDLALVSGKLESGSIQPGESLTIYPSE---------QSCIVDKIQVGSQQGQEETDVAIKGDFVTLRKAYPEDIQNGDLAASVDYSSIHSAQCFVLELTPFILFIGVKEQPARIKRLISFIDKGNTASKLGSKQRAFVEIE-LIEVKRWIPLLTAHERLGRVVLRKDGRTIA........................................................................................................................................................................................................................................................................................ 602
17 -23.500[R] COG5258 GTPase  ali follow..  16  109....................TVVALGNVDAGKSTLVGVLT--TGRLDDGKGLARSYASRYKHEVLTGRTSAVSLRLLGFSGDKVVNHGLIDPLDEAEV-------KRSDKLVLLVDVGGHERYLRTALRGLSQPDYVMLVVAANSGVQKMTKEHLGIAVAIGIPVFVVVTRIDITPSEFQKTVEEVVRILKMPGVSKIPYIIKDTNDVVLAAKAMPAGRVAPVFYVSSVTGHGLD------------------------------------------------------------------------------------------------------------LLLRFLSLLPRRRRWD-------------------------YGGEFLMYISDIYLVKGVGVVIGGLVEKGILHVGDRVWL------PYSDGKWMQTVVKSIHF----NRTPVESAKAGSFITVA--KGMVLSARPLKAVREVTADVLVLRHPTVITGGYIKEIDKGELMVGDSGVVKIELSRPWH-----DSGVFVFRILGRI.................................................................................................................................................................................................................................................................................................................. 508
18 -22.800[J] KOG0459 Polypeptide release factor 3  ali follow..  13  95............EANKKRHLNVVFIGHVDAGKSTIGGQILFLSGQVDDRQIQKYEIMDTNEEERLKGKTVEVGRAHF----------------------------ETESTRFTILDAPGHKSYVPNMISGASQADIGVLVISARKGE--QTREHVQLAKTLGVSKLIVVNKMDDPTVNWS------KERYDEIEQKMVPFLKASGYNTKKDVVFL-----------SGLMGKNMDQRMGQEICP-------------------------------------------------------------------------------------------------PSFFEVL-DSIEIPPR-------------------------DPNGPFRMPIIDKF---KDMGTVVMGKVESGSIREGDSLVVMPNK---------EQVKVVAIYC----DEDKVKRAGPGENLRITGIEDEDILSGFVLSSIVNPVPAVTEFVAQLQIKAILHIHAVVEECEIIELKSQIDLKTRKPMVKNGAAVVCRIQVTNSICIEKFSD---PQLGRFTLRTEGKTIA........................................................................................................................................................................................................................................................................................ 518
19 -19.600[J] KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase)  ali follow..  16  183.....................VTIMGHVDHGKTTLLDK-FRKTQVAAVETG---------------GITQHIGAFLVSLP---------------------------SGEKITFLDTPGHAAFSAMRARGAQVTDIVVLVVAADDGVMKQTVESIQHAKDAQVPIILAVNKCDKAEADPEKVKKEL--------------------------------------------------------------LAYDVVCEDYGGD------------------------------------------------------------------VQAVPVSALTGDNLMALAEATV------------------------LAEMLELKADPNGPVEGTVIESFT-DKGRGLVTTAIIQRGTLRKGSVLVA---------------KCWAKVRLMFDENGKTIDEAYPSMPVGITGWRD------------------------------------------------------------LPSAGEEILEVESEPRAREVVDWRKYEQEQEKGQEDLKIIEEKRKEHKEAHQKAREKYGHLLWKKRSILRFLERKEQIPLKPKEKRERDSNVLSVIIKGDVDGSVEAILNIIDTYDASHECELELVHFGVGDISANDVNDGVIYGFNVNAGNVIQQSAAKKGVKIKLHKIIYR------------------LVEDLQEELSSRLPCAVEEHPVGEASILATFSVTEGKKKVPVAGCRVQKGQLEKQKKFKLSLTSLKHHKDDISIVKTGMDCGLSLDEDNMEFQVGDRIVCYEEKQIQAKTSWDPGF.............. 727
20 -17.900[J] COG3276 Selenocysteine-specific translation elongation factor  ali follow..  15  3.....................IVTSGHVDHGKTALLKAL---TGT-----------TAHLPEEKKRGMTIDLGYAYLPLENKV----------------------------LGFIDVPGHEKFLSNMLAGLGGVHYAMLIVAADEGVAVQTKEHLAILRQLQFHEIVVITKADRTNSAQIESLIQTIKQDYSFLRNANYFVTSAETGQ-----------------------------------------------------------------------------------------------------------------------------------GISELRHYLANLAELADTQKPFRYA----------------------------IDRVFSVKGAGTVVTGTAFSGTVKVNDEIYLST----------GQKIRIKAIHA----QNTSSEQGIAGQRLALADLDRTPMKRGDWLLQNEP-------LPPTDRISVQILPLNESQPVHIYHGASRTTGKLTLLQGKNAAKND---RTLAEIILD----------SPLFLAFGDKLIDTKTLIAGARVLEINSPKRHKRTEVRLNFLANLAL-AENASQRIALTLQHNATTARQLMWTEQLTSLQLDKALAERDAVRYQDWCFNPNYVQEKTQQILTALNIGVSKARLYRMATLNQPENLIHHFIDEMLDDGRLQQTRGWILPEHKIQFNTEEKSRWTDVLNEFEKANGQAIWRDMANALAIDESIMRNFMYKAGKLGYLTPIVKDRFFLTETLAYARLIKQIAEEKGKVS-----------------------VNEVRDKLNFGRKLTVLMEYFDRM 599
21 -17.500[E] COG4917 Ethanolamine utilization protein  ali follow..  15  1..................MKRIAFVGSVGAGKTTLFNALQGNY----------------TLARKTQAVEFNDK---------------------------------------GDIDTPGHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIG--VSKRQIAVISKTDMPDADVAATRKLLLE........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 117
22 -16.900[R] KOG2486 Predicted GTPase  ali follow..  14  113AQVVQADYVKSSVKPADGLPEFALVGRSNVGKSSLLNSLVRRKRLATSKKPGKTQCINHFRINDK----------------------------------------------WYLVDLPGY-KFTKDYFLNRSTLVSVFLLVDASIPVKPIDLEYASWLGQNQVPMTLIFTKCDKRKKK-KNGGKKPEANIKEFQDLIQ.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 281
23 -16.800[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  16  53................TKSNTVLLSGLSGSGKTVLFYQL-------------------------RDGSSHQGAVTSM------------EPNEGTFVLHNENNTKKGKVKPVHLIDVPGHSRLISKLEEYLPRAAAVVFVVDALE-IRAASEYLYDSVIKNKTPVLLCCNKTDKVTA---HTKEFIRKQMEKEIDKLRV............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 203
24 -16.100[R] COG3596 Predicted GTPase  ali follow..  15  16LSGLPLWVSERILQQINQLTHIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTR--DPLRFRLQ------------------------------------------GEHFMTIVDLPGDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYKMLFVISQSDKA..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 160
25 -15.600[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  18  448.....................VTIMGHVDHGKTTLLDR-FRESRVTEGEAG---------------GITQHIGAYQI----------------------------KANGKKITFLDTPGHEAFTSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAAGVPIIVAINKIDKPGANPQRVTQELTEH---------------------------------------------------------------GVFPVAWD---------------------------------------------------------------PENGSEFVEISAKFNQNLDELLDTVL------------------------VAEVQELKADPTVRAIGTVVEARL-DQGKGAIATLLVQQGTLHVQDPIVV---------------NTYGRVRTMTNDLGRRIKEAGPSTPIELTGLSDVPQAGDHFAVFEDEKAARAAGEERAKRAQIKRQNTRRVNLDNLFDTLKEGQTKSVNIIIKADVQGEALAASLQKIEVEGVKVDI--------VHSAVGAISESDISLAAAS----------------------------------------------------------------------------------------NAIIIGFNVRPTGLAREQAAQEEVDIRLHSIIYK------------------VIEEVETAMRGMLDPEFKEEIIGEAI-VRETFNV--SKVGTIAGFMVIRGKVARDASVRVAIASLKHFKDDVKEVGNA--EGGLMVEDFNDVEID---DTFEVYKMVEIERK.................. 944
26 -14.300[R] COG2229 Predicted GTPase  ali follow..  16  5....................KIIFTGPVGVGKTTAIAAISDEALVQTDASASDMTL----DRKRNTTVAMDYGAISL-----------------------------DEDTKVHLYGTPGQERFNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGKAPVVVGITKMD....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 127
27 -14.100[R] KOG0395 Ras-related GTPase  ali follow..  17  1MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGR---------EDQYTPTIEDFHRKVYNI-----------------------------------RGDMYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEELPMVICGNKNDHGELCRQVPTTEAELLVSG.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 162
28 -13.900[R] COG1084 Predicted GTPase  ali follow..  18  148....AKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAEPEVAD------------------FTTKGIQIGHLERKWKR----------------------------IQVIDTPGLLDRPVEMVALENIADVIMFIFDASETCESQYSLYLGIRSVFDIPVVTVFNKMDLA------ENVKYLEEYINMVEDPLKVSAFEGRGVSKIIKKLEGLYEKE...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 328
29 -13.400[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  11  59......GYKDKLSIIGEVLSRVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEGTDGDK--------AYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRLVLVDSPG--ELDSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNEWLSKPNIFINRWDASASEPEYMEDVRRQHMERCLHFLVEELKVANALEAQNRIFFVSVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSA---VKTKFEQHTIRAKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDIRNQMNLLTLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 425
30 -12.800[R] COG0218 Predicted GTPase  ali follow..  3LNTHNAEILLSAANPQDELPEIALAGRSNVGKSSFINTMLNRKNLARSGKPGKTQLLNFFNIDDK----------------------------------------------MRFVDVPGY-CMIEEYLTTRENLRAVVSLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKI-GKWNKHESAIKKKLN..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 166
31 -12.600[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  14  95.....................ILLVGQYSTGKTTFIRYLL-FPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVDAKKQFRALSGFGNAFLNRFQCSTLPNQVLES----VTIVDTPGILDFTGVLEWFAERVDRIILLFDAHKDISDEFKRCIEALAGNEDKIRIVLNKSDMV------DHQQLMRVYGALMWSLGKVFKT......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 280
32 -12.100[F] COG1618 Predicted nucleotide kinase  ali follow..  18  2..........RIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGGIRTAEIRKEGHREGFSIRDTGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIGPMELISQVSAVEEVLESDKPVLAV---LHHSSRHPLAQRFRKGFE-VLTVDKGNR-----DELPEKITNRFLRKL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 183
33 -12.000[R] COG1160 Predicted GTPases  ali follow..  15  217....................KIAIVGRPNVGKSTLTNRILGEDRVVVFDMP---------------GTTRDSIYIPMERDGQQ----------------------------YTLIDTAG----VIKTLQAIQDANVVLLTIDARENISDQDLSLLGFILNAGRSLVIVVNKWDGLDQDVKDRVKSELDRRLDFIDFARVHFISALHGSG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 373
34 -11.500[T] KOG3886 GTP-binding protein  ali follow..  13  26....PEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANY---------------IARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLLNLWDCGGQDTFMENYFTSFRNVEVLIYVFDVESRELEKDMHYYQSCLEADAKIFCLVHKMDLVQEDQRLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVY........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 239
35 -11.400[R] COG1159 GTPase  ali follow..  19  1...........MSTDKTYCGFIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTR-------HRIVGIH------------------------------------TEGPYQAIYVDTPGNRLMNKAASSSIGDVELVIFVVEGTRWTP-DDEMVLNKLRDGKAPVILAVNKVDNV..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 129
36 -11.400[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  13  6......KGLYNNWNKKEQYS-ILILGLDNAGKTTFLETLKKEYSLAFKALEKIQPTV---------GQNVATIPV-------------------------------DSKQILKFWDVGGQESLRSMWSEYYSLCHGIIFIVDSLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDR---MEVQDIKEVFNKIAEHIS.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 158
37 -11.000[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  12  14....................KLVLVGDGGTGKTTFVKRHLTGE---------------EKKYIATIGVEVHPLSFYT----------------------------NFGEIKFDVWDTAGQEKFGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRNIPIVLCGNKVDVKERKVKAKTITFHRKKNLQYYDISA............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 153
38 -10.800[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  12  2................KRPLIIGVGGPVGAGKTMLIERLLSTKGYSMAAITNDIYTKEDARILLNTSVLPADRIAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDLQLL--FLESGGDNLSATFSPD---LVDFSIYIIDVAQG----EKIPRKGGQGMIKSDLFIINKVD-LAPYVGANVEVMKADTLKSRGNKDFFVTNLKTDEG................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 187
39 -10.800[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  13  3LFDWFYGILASLGLWQKEAK-ILFLGLDNAGKTTLLHML---------------KDERLVQHQPTQHPTSEELSI--------------------------------GKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDAFAESKRELDALLSDEALATVPFLILGNKIDIPYA---ASEDELRYHLG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 147
40 -10.800[P] COG0370 Fe2+ transport system protein B  ali follow..  11  5....................TYCILGNPNTGKTSLFNALTGSYEYVGN------------------GVTVEKKVGTL------------------------------RSKTGKLIDLPGIYDLSRDETVVTRFLDCMLNIVDSSQ---ERNLNLTVQLLEYGAPVVMGLNMIDVAAGRIHLNIQNLAKKLRIPILPVVA---RSGKGTEDILSTLSEKHVAPAIPLVLQYGEPAEIPAKQSRWLAIQFLSKNEVTEAFLTSNSAFEQLQQIRAELESELNGKLENHFHQVRASYIHDICLTSVEYTRNSDIPLSDKLDKIFTHK--LGIMWLIFQITFTWVGAPLSDMLDGFIGGS-LTTIGASGFIIDLVADGIIAGVGGVLVFVPQILVIFFFISVLEDSGYMAMDRVMEIFGLNGKAFIPM-PGIMAARSIEESKERTLTILVMSCSARLPVYALFVG-IGILMALIVTKILSKTILKKDNSVFVVELPPYRLPSLKTLWRSTWEKGKGFLRKAGTFIFAGSVIIWLLDVPMGESFLAIIGGM-LAPLLVPLGFGTWQAGATLIPGFLA-KEVVVSTMAI............................................................................................................................................................................................................................................................................. 586
41 -10.700[R] KOG0394 Ras-related GTPase  ali follow..  16  1...........MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKK---------------SNQYKATIGADFLTKEVQF----------------------------EDRLFTLQIWDTAGQERFQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCASKGNIPYFETSAKVGTNVE................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 166
42 -10.700[R] KOG1673 Ras GTPases  ali follow..  103....................KISLLGDCQTGKTTFVVKYVGDE---------------NQSFLEMTGLNLMDKTFYV----------------------------QGVTISFSIWDVGGD--SKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQARKTAIPILIGTKFDDFVRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARLF.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 267
43 -10.700[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  16  1...........MDEDVLTTLKILIIGESGVGKSSLLLRFTDDT---------------DPELAATIGVDFKVKTISV----------------------------DGNKAKLAIWDTAGQERFRTLTPSYYRGAQGVILVYDVTVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFAR....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 141
44 -10.600[R] KOG1533 Predicted GTPase  ali follow..  16  16.VYATSEKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLTDIFSQTKRNLDPANDTMAYAPDNITEMITVNDVMDRLGLGPNGALKYCIETLGANCNWLLQKIEANHKKYL--IIDCPGQLELYKSEGELWKVIR-ALHLADSISVALSTLATMVT-----EMPQVNCLSKAD....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 205
45 -10.600[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  16  1MSDGDYDYLIKFL----------ALGDSGVGKTSVLYQYTDGK---------------NSKFITTVGIDFREKRVVY------------------RASGPDGATGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTLNVRNWISQLQMHAYCENPDIVLCGNKSD-----LEDQRVVKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIM.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 182
46 -10.600[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  19  155.....RQHMARLPSIDPNTRTVLICGYPNVGKSSFMNKV-----------------TRADVDVQPYAFTTKSLFVGHT---------------------------DYKYLRYQVIDTPGILDRPFESITALAHLRAAVLFFSGSCGYTIAQQAALFHSIKSLFPLVIVCNKTD-------MPMENISEEDRKLIEEMK.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 311
47 -10.400[R] COG0523 Putative GTPases (G3E family)  ali follow..  16  1...............MTPIAVTLLTGFLGAGKTTLLRHILNEIAVIENEFGEVSVDDQLIGDRATQIKTLTNGCICCTRSNE----------EDALLDLLDSRDRGDIAFDRLVIECTGMADFSHDVLCERYLLDGVIALVDAVHANE-QMNQFTIAQSQIGYADRILLTKTDVA---------GDSEKLRERLARIN.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 177
48 -10.400[K] KOG1534 Putative transcription factor FET5  ali follow..  12  8.......................VCGVASSGKSTFCGALMSYMKSVGRNLDPAAENFEWEPTDIRDLISIDDVMEELDYGPNGGLIYCFEFLMENLDWLNEEIGDYDEDYL--IFDMPGQIELYTHVPILPALIR-AVYLLESQTKFFAGVLSAMSAMVMMEVPHINLLSKMD....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 176
49 -10.300[H] KOG2743 Cobalamin synthesis protein  ali follow..  16  36............SGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKR-SALEKSLAVSQGGELYEEWLELRNGCLCCSVKDN--------------LRAIENLMQKKGKFDDILLETTGLADWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVILINKTD-------LVPEEDVKKLRTTIRSIN.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 224
50 -10.300[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  15  46.......................VVGMAGSGKTSFLHRLVCHTFDSKSNLDPAVMSLPFGANIDIRDVKYKEVMKQYNLGPNGGILTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFTWSASGAIITE-VTYVVDTMSNMLYACSILYK-----RLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTATLANSLSLSLYEFYRNIRSVGVSAISGAG----MDGFFKAIEASAEEYMETYKADL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 295
51 -10.200[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  15  22....................ELTLVGLQFSGKTTFVNVI-------------------------ASGQFAEDMIPTVGFNMRK----------------------TRGNVTIKVWDIGGQPRFRSMWERYCRGVNAIVYMVDALEASRNELHSLLDKPQLAGIPVLVLGNKRDLPGA---LDETGLIERMN..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 148
52 -10.100[T] KOG4252 GTP-binding protein  ali follow..  13  2...........LEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGI---------------TKDYKKTIGVDFLERQIQV----------------------------NDEDVRLMLWDTAGQEEFDAITKAYYRGAQACVLVFSTTDRGSFEAVSSWREKVVADIPTVLVQNKID-----LLDDSCIKNEEAEALAKRLRLRFYRTSVKEDLNVNEVFKYLAEKYL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 170
53 -9.920[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  16  1MGNIFSSMFDKLWGSNKELR-ILILGLDGAGKTTILYRL---------------QIGEVVTTKPTIGFNVETLSY--------------------------------KNLKLNVWDLGGQTSIRPYWRCYYADTAAVIFVVDSMSTASKELHLMLQEEELQDAALLVFANKQDQPGA---LSASEVSKELN..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 145
54 -9.860[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  19  19....................RILLLGLDNAGKTTLLKQL---------------ASEDISHITPTQGFNIKSVQS--------------------------------QGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSFEETGQELAELLEEEKLSCVPVLIFANKQDLLTA---APASEIAEGLN..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 144
55 -9.800[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  15  1MVEPIFEYQFRLI----------LIGDSTVGKSSLLKFFTDGK---------------AELSDPTVGVDFFARLIEM---------------------------KDGTQIKLQLWDTAGQERFRSITKSYYRNSVGVLLVYDISEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVT--TEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVY.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 176
56 -9.770[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  18  5......TILKKMKQKERELR-LLMLGLDNAGKTTILKKF---------------NGEDIDTISPTLGFNIKTLEH--------------------------------RGFKLNIWDVGGQKSLRSYWRNYFESTDGLIWVVDSMQDCQRELQSLLVEERLAGATLLIFANKQDLPGA---LSSNAIREALE..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 143
57 -9.760[R] COG1163 Predicted GTPase  ali follow..  15  56.........IGFDVARTGVASVGFVGFPSVGKSTLLSKLTGTESEAAE-------------------TTLVTVPGVIRYKGAK----------------------------IQMLDLPGIIDGAKDVIAVARTCNLLFIILDVNKPLH-HKQIIEKELEGVGIPPDILIKKKEKGGISITNT.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 195
58 -9.740[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  14  1...........MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDS---------------LDSYISTIGVDFKIRTVEQ----------------------------DGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWDRYASENVNKLLVGNKCD....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 124
59 -9.660[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  5........VGDSSGSPKPIR-IVVVGEKGSGKSSLIMAAARNT---------------------------------------------HPNIPSLLPYTNLPSEFFPDRIPATVIDTSSRPEDKGKVVKEVRQADAIVLTFATLDRLSKYWLPLFRQL-EVRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYREVETSIQWSAQRLDQAKD----------VLYYAQKAVIDPVGPVFDQENNVLKPRCIAALKRIFLLSDHNMDGILSDEELNELQKKCFIKQMKNVMQVTFPQGVNERGLTLDGFLFLNTRLIEEARIQTLWTMLRKFGYSNDLRLGDDLVPYSSFKRQADQSVE-EFFDSNGDNNLEPHEMGYLFETAPESPWTKPLYKDVTEENMDGGLSLEAFLS-PSDDPSSAVRVTRKRVLDRKEKKSERKVVQCFV--------FGPKNAGKSALLNQFTDKTLVLKEVRIKDDGFMLSKEALAACDVAIFIYDSSDEYSWNRAVDMLAEVAKTDLDPFPVAIQESTRVTQDIG-IPISSKLGDVSNLFRKILTAAENPHLNIPEIESKKKRSCKLNNR....................................................................................................................................................................................................................................................................... 620
60 -9.550[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  17  1...........MAETYDFLFKFLVIGSAGTGKSCLLHQFIENK---------------KQDSNHTIGVEFGSRVVNV----------------------------GGKTVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNSLAAWRTLASPNIVVILCGNKKD-----LDPEREVTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTIL.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 170
61 -9.540[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  18  55.........EGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAA-------------------TTLTTVPGVIRYKGAK----------------------------IQLLDLPGIIEGAKDVIAVARTCNLILIVLDVLKPLG-HKKIIENELEGFGIPPNIGFKKKDKGGINLTAT.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 194
62 -9.460[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  14  1MDGGVLSYFRGLLGSREM--RILILGLDGAGKTTILYRL---------------QVGEVVTTIPTIGFNVEQVTY--------------------------------KNLKFQVWDLGGQTSIRPYWRCYYSNTDAIIYVVDSIGISKDELLYMLREEELAGAILVVLANKQDMDGC---MTVAEVHHALG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 144
63 -9.450[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  13  3............MEDYDFLFKIVLIGNAGVGKTCLVRRFTQGL---------------PPGQGATIGVGFMIKTVEI----------------------------NGEKVKLQIWDTAGQERFRSITQSYYRSANALILTYDITCEESFRCLPEWEQYASNKVITVLVGNKID....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 125
64 -9.410[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  15  6......GKLFSRLFAKKEMR-ILMVGLDAAGKTTILYKL---------------KLGEIVTTIPTIGFNVETVEY--------------------------------KNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSVVEARDELHRMLNEDELRDAVLLVFANKQDLPNA---MNAAEITDKLG..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 144
65 -9.390[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  14  1........MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKK---------------MADCPHTIGVEFGTRIIEV----------------------------SGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWRNLTNPNTVIILIGNKAD-----LEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIY.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 173
66 -9.370[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  22  1MSTKSYDYLIKLL----------LIGDSGVGKSCLLLRFSEDS---------------TPSFITTIGIDFKIRTIEL----------------------------DGKRIKLQIWDTAGQERFRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWEQHASENVYKILIGNKCD....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 125
67 -9.340[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  14  23....................RILMLGLDAAGKTTILYKL---------------KLNQSVVTIPTVGFNVETVTY--------------------------------KNIKFNVWDVGGQDKIRPLWRHYFTGTKGLIFVVDSISEARQELHRIISDREMRDCLLLVLANKQDLPGA---LSPAQITDVLQ..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 148
68 -9.290[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  15  22....................KLVLLGESAVGKSSLVLRFVKGQ---------------HEFQESTIGAAFLTQTVCL----------------------------DDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNEESFARAKNWQRQASPNIVIALSGNKAD-----LANKRAVDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKL..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 181
69 -9.270[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  15  1MASVSPLAKYKLV----------FLGDQSVGKTSIITRFMYDK---------------DTTYQATIGIDFLSKTMYL----------------------------EDRTVRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWRNERAGDVIIVLVGNKTD-----LVEKRQVSIEEGDSKGREYGVMFIETSAKAGFNIKPLFRKIAAAL..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 170
70 -9.270[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  17  450IRMISSSKAPEEEDEFDIMGKVIMLGDSGVGKTSLLIR--FRDGRYVPSYFLSTVGIDF----RNKVVVVDGTRVK-----------------------------------LQIWDTAGQERFRSVTHAYYRDAHALLLLYDVTNKTTYDNIRAWREYAQEDVVIVLIGNKADCSGSERQVKRED-----ERLGREHNVPFMETSAKTGLNVELSFTAVARQL..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 631
71 -9.240[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  12  2........LETNVDQKSFKFKIVLLGEGCVGKSSLVLRFVENK---------------SCKHLSTIQASFQNKTVNV----------------------------EDCQADLHIWDTAGQEKYHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWKTCLGNTAEILIVGNKID-----LEEERQVTRQDAEAYAESEGALYMETSAQDNVGISDAFESLTAKMI.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 174
72 -9.190[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  13  8....RYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDS---------------TPAFVSTVGIDFKVKTIYR----------------------------NDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWKTYSWDNAQVLLVGNKCD....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 138
73 -9.130[F] COG0572 Uridine kinase  ali follow..  12  1...........MTDKAHQCVIIGIAGASASGKSLIASTLYRELREQVGDQHIGVIPEDGYYKDQSHLSMEERVKTNYDHPSAMDHNLLLEHLQALKAGKP--------------VELPLY-SYTERKKETVHLEPKKVIIL---EGILLLTDIRLRQEMNFSILDICLMRRMKRDVNERGRSMDSVMAQYQKTVRP................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 174
74 -9.000[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  11  363....GNDLFVNANLLIAHGRRYGLVGPNGHGKTTLLRHIIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQEELNDTFAELKAIGAYSAEARARRIL---AGLGFSKEQDRPTNKFSGGLLMLD-TNHLDLNAVIWLDNYLQGWKKTLLIVSH-DQSFLD-------------------------------NVCNEIIHLDQKKLQYYKG------NYSMFKKMYVQKRREMIKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFRFPEPSQLQPPILGVHNVTFAFPSQKPLFIKVDFGIDLTSRVA------------------------------------IVGPNGVGKSTFLKLLLGELEEGEQRKNHRLHVGRFDQHSGEHLTAEESAAEYLQRLFNLPHEKARKALGSFGLHAHTIKMKDLSGGQKARVALAELCLSAPDVLILDEPTNNLDIESLAEAINEY-------------EGGVIIVSHDERLIRETGCTLYVIEDQTINEIVGEFDDYRKEVLDSLGEVVNNPSVVANA.................................................................................................................................................................................................................................................................. 897

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Godzik A. JAFA: a protein function annotation meta-server. Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W379-81.