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Query: [E] KOG0503 Asparaginase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDIPVLKTNGHERLASLDKSMPPASPTLPSPTIRRNKSDGKLMAQDVKEARVKVIYTGGTIGMVRNERNVLAPIPNALVRSIRKYPNIHDEEYALRRFGASASMAPLVLPIVQGVDRRVIYQISEYTPLLDSSNMTMNDWARIASDIQQSYEFFDGFVVLHGTDTLSYTASALSFMLENLGKTVIITGSQIPIFETRTDGKDNFTSALIIAGNYIIPEVCIFFGHKLMRGNRTVKVSSNALDAFDSPNVPPLARIGIDVNVDYRLIFRPCTIERFCVHLNLDENVGLLRIFPSISHSTFRAFLAPPIRGVVLQSFGSGNIPSNRKDLIDELRAAGERGVIIINCTQCPNGTVAEIYDTGKVLCDVGVIPGFDMTPEAALAKLAYVIGKEEWSLDMKKQMMQSSLRGELTSLKAPKMEDYDLVDAVARSLHLSSPQELDQLGETLFPAMINAAVAEGDPKKINNLKAYGADLSGTNHDQRTALHLACQLGNVEIVKYLLQNGVSVHVRDRYDRTPLLEAVATDSHEIIQLLINCGAHLTGSSRAVGEQLCAAAARGSMIRLKSYQYAGADLAQSDPSGRTALHVAALHGFPEVVQYVLPYFENPNEKDMLGLTAMDYAERGGHAAVMEVLKSLast
1 -174.000[E] KOG0503 Asparaginase  ali  100  1MDIPVLKTNGHERLASLDKSMPPASPTLPSPTIRRNKSDGKLMAQDVKEARVKVIYTGGTIGMVRNERNVLAPIPNALVRSIRKYPNIHDEEYALRRFGASASMAPLVLPIVQGVDRRVIYQISEYTPLLDSSNMTMNDWARIASDIQQSYEFFDGFVVLHGTDTLSYTASALSFMLENLGKTVIITGSQIPIFETRTDGKDNFTSALIIAGNYIIPEVCIFFGHKLMRGNRTVKVSSNALDAFDSPNVPPLARIGIDVNVDYRLIFRPCTIERFCVHLNLDENVGLLRIFPSISHSTFRAFLAPPIRGVVLQSFGSGNIPSNRKDLIDELRAAGERGVIIINCTQCPNGTVAEIYDTGKVLCDVGVIPGFDMTPEAALAKLAYVIGKEEWSLDMKKQMMQSSLRGELTSLKAPKMEDYDLVDAVARSLHLSSPQELDQLGETLFPAMINAAVAEGDPKKINNLKAYGADLSGTNHDQRTALHLACQLGNVEIVKYLLQNGVSVHVRDRYDRTPLLEAVATDSHEIIQLLINCGAHLTGSSRAVGEQLCAAAARGSMIRLKSYQYAGADLAQSDPSGRTALHVAALHGFPEVVQYVLPYFENPNEKDMLGLTAMDYAERGGHAAVMEVLKS 631
2 -64.500[O] KOG4412 26S proteasome regulatory complex, subunit PSMD10  ali follow..  18  2.................................................................................................................................................................................................................................................................................................................................................................................................................EIATDTAKQMRDEELFKAAEWGDSSLFMSLSEESKSLNFRNEDGRSLLHVAASFGHSQIVKLLSSSDTVINSKDDEGWAPLHSAASIGNAELVEVLLTRGADVNAKNNGGRTALHYAASKGRLEIAQLLLTHGAKINITDKVGCTPLHRAASVGKLEVCEFLIEEGAEIDATDKMGQTALMHSVKVSMDQVAFLLIRHGADVDVEDKEGYTVLGRATNEFRIDAAKAMLE 246
3 -56.300[OT] KOG0505 Myosin phosphatase, regulatory subunit  ali follow..  17  3........................................................................................................................................................................................................................................................................................................................................................ELEHLGGKRAESARMRRAEQLRRWRGSLTEQEPAERRGAGRQPLTRRGSP------------RVRFEDGAVFLAACSSGDTDEVRKLLARGADINTVNVDGLTALHQACIDENLDMVKFLVENRANVNQQDNEGWTPLHAAASCGYLNIAEYFINHGASVGIVNSEGEVPSDLAEEPAMKDLLQWLNSGKIEDVRQARSGATALHVAAAKGYSEVLRLLIQAGYELNVQDYDGWTPLHAAAHWGVKEACSILAEALCDMDIRNKLGQTPFDVADE-GLVEHLELLQK 303
4 -55.700[R] KOG0514 Ankyrin repeat protein  ali follow..  16  44......................................................................................................................................................................................................................................................................................................GSEVASLTQPEKSTGRVPTQEPTHREPTRQAASQESEEAGGTGGPPAGVRSIMKRKEEVADPTAHRRSLQFVGVNGGYESSSEDSSTAENIQECQLSRESQHIPTAEGASGSNTEEEIRMELSPDLISACLALEKYLDNPNALTERELKVAYTTVLACRSDAHPELVRRHLVTFRAVNIADSNGNTALHYSVSHANFPVVQQLLDSGVKVDKQNRAGYSPIMLTATQDDIETVLQLFRLGNINAKASQAGQTALMLAVSHGRVDVVKALLACEADVNVQDDDGSTALMCACEHGHKEIAGLLLAVSCDISLTDRDGSTALMVALDAGQSEIASMLYS 440
5 -55.600[I] KOG0817 Acyl-CoA-binding protein  ali follow..  13  1.............................................................................................................................................................................................................................................................................................................................................MASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAELFEKAAAHLQG--------------------LIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKALGDSSPSQAMQEYIAVVKKLDPGWNPQIP-KGKEANTGFGGPVISSLYHEETIREEDKNIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADINCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQRHTT 279
6 -51.500[R] KOG2384 Major histocompatibility complex protein BAT4, contains G-patch and ankyrin domains  ali follow..  11  2.................................................................................................................................................................................................................................................................................................................................NSQNELHPNWLALTTLPLQLKRFVRAGDPD-----------FIAESPKAVKHQIDGLNGAEA-----------------------REFYKEVLDAPTTCQPNLPSTHKTAQTRREPERILVPFDKSKFFRLATSNKVEELSQMKASEEDLNSRDSFGWTALMMAACEGATEAVSWLVQRGVQVETSDKSGNTALKLAQRKGHLDVVHLLESLPTSEEDESVDGNNPFYCEICKRDYKETPWPIHQTSTVHQFNLKALPKLHKFNISAKNRGLQLMVKQGWDQE--------HGLGPSQSGRLYPVKTVLR 275
7 -51.000[R] KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins  ali follow..  17  2..........................................................................................................................................................................................................................................................................................................................EGPGQCRNHSHGPHPPGFGRYGICAHENKELANAREALPLIEDSSNCDIVKATQYG-----------------------------------------------------IFERCKELVEAGYDVRQPDKENVSLLHWAAINNRLDLVRFYISKGAVVDQLGGDNSTPLHWAIRQGHLPMVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAHKVGPEPTGFLLKFNPSLNVVDKHQNTPLHWAVAAGNVNAVDKLLEAGSSLDIQNVKGETPLDMALQNKNQLIIHMLKT 271
8 -50.700[R] KOG0508 Ankyrin repeat protein  ali follow..  13  10....................................................................................................................................................................................................................................................................................................LLDTWIIHWEQQQTEMKLVFKNIPYKPAQTKIFQGVRLNFAGVKSPHETLQVLFQQLGEIPNTSQEGLPPHPCMALRESFLSTCYCEAFNPSS-------PPLSSLALSFKVSGDCHKQGLTQGLLLLLCGLVEPVGLVPVATAGGRRGDAAAHRRLLRPPGRGGVPGGPVRRERGGWLGALRWRDRGGCAAAVGADHLDVVRSLLRRGASVNRTTRTNSTPLRAACFEGLLEVVPYLVEHQANLEVANRHGHTCLMISCYKGHREIARYLLEQGAQVNWRSAKGNTALHNCAETSSLEILQLLLGVTGHTNIEQVTGVEAQPGLPQEGSSTSQGCRQP 367
9 -49.100[EJ] COG0252 L-asparaginase/archaeal Glu-tRNAGln amidotransferase subunit D  ali follow..  17  18..........................................VFSTTSLPHIVILATGGTIAGTAANNTGYKSGELGVQTLINAVPEMNNIARVD----------------------------GEQVANIGSENMTSDIILKLSQKVNAARDDVDGVVITHGTDTLDETAYFLNLTVKS-DKPVVFTAAMRPASAISADGAMNLLEAVTVAADPNARGVMVVLNDRIGSARFVTKTNATTLDTFKAPEEGYLGVIVNGQPQFETRVEKIHTLRSDVRNIKKLPNVVIIYGYQDDPEYMYDAAIAHHADGIIYAGTGAGSVS---VRSDAGIKKAEKAGIIVVRASRTGNGVVPLDKGQP-------GLVSDSLNPAKARVLLMTALTQTRNPELIQSYFST...................................................................................................................................................................................................................................... 346
10 -45.800[E] KOG1709 Guanidinoacetate methyltransferase and related proteins  ali follow..  17  3............................................................................................................................................................................................................................................................................................................................................................................................................................................................EADQLCLAAKSGDLKKVQTLIYSGADVTHFDNDGLTPLMHAAKIGNAEIVTALLESGAPWNALSPSNLSAGDFAMEAGHQETFDLLLKTGIQSELILGTIARNQTKNEYSNQEYLQDRVSFMDSESKGVMMAWEKPLMEAHAKAICLNGGHILNVGFGMGLVDTQRYNPVKHTIIEAHPEVYKRMIE 196
11 -45.000[R] KOG1710 MYND Zn-finger and ankyrin repeat protein  ali follow..  13  1.....................................................................................................................................................................................................................................................................................................................................................................................................................................................MTTTEEAPKSPLFEAIDKNDTEAALALLKTKEQAAQRDPSGMSVLAAAAYRGNLTLVEKAIELKCDVNDKDGTLYTPLMFAALSGKQDVCRLLMDSGARMYLVNGIGKTASELAAFVGHHECVAIINN-HITIDVIERFSKYPDSLKYKKKILYVIDRVFEKQLRCKESNEIMSLKLWLILGDETRRALDVMLR 269
12 -44.000[PT] KOG3676 Ca2+-permeable cation channel OSM-9 and related channels (OTRPC family)  ali follow..  13  2........................................................................................................................................................................................................................................................................................................KKWSSTDLGAAADPLQKDTCPDPLDGDPNSRPPPAKPQLSTAKSRTRLCPHEEGELDSCPTITVSPVITIQRPGDGSTGARLLSQDSVAASTEKTLR---------------LYDRRSIFEAVAQNNCQDLESLLLFLQKSKKKDPETGKTCLLKAMLNLHTDSLKELV--NASYTDSYYKGQTALHIAIERRNMALVTLLVENGADVQAAAHFGELPLSLAACTNQLGIVKFLLQNSADISARDSVGNTVLHALVEVADNTADNTLHPTLKLEELTNKKGMTPLALAAGTGKIGVLAYILQREIQEPECRHLSRKFTEWAYGPVHSSLYDLSC. 387
13 -43.000[R] COG0666 FOG: Ankyrin repeat  ali follow..  9  2............................................................ITHIPRSSFSANINNTAQTNEHQTLSELFYKELEDKFSGKELATPLLKSFSENCRHNGRHIDFVIKFSISVLQADKKEITIINKNENTTLTQTIAPIFEEYLMEILPQRSDKKELNLNSDRKEKEFPRVKLNGQCYFPGRPQNRIVCRHIAAQSSAEKFLTHFNKKYFDKMESNDLSVMAAILLVDNHALTVYDPNVTNDKIRIMSESKEDIKHYSLMDFMNVD------YSLLKWSNDHVINQSVAIIPALPKEQLLMLKGTVDEITPLMAIGQNHQLKQLMIQLQKMPELTAYNSINLPGLYLAINYGNADIVETIFNSLSEPGYEGLLSKKNLMHILEA-----KDKNGFSGLFLAISRKDKNVVTSILNALPKLAAKNSTSSHVLYHVMANGDADMLKIVLDALSLLKAKDFYGCPGLYLAMQNGHSDIVKVILEALPSLAAKSLARDTGLFMAMQRGHMNVINTIFNALPTLLANNSNEYPGLFSAIQHKQQNVVEMVYLALSDWQHKAPQKYSAFELACELGHRVIAELIFNTLNKMAESFGFTDNPRYIAEKNYMEALLKKASP 724
14 -42.700[T] KOG4335 FERM domain-containing protein KRIT1  ali follow..  15  1...........................................................................................................................................................................................................................................................................................................................................................................................................................................................MGYSALEIKS--------KMLALEKADTCIYNFGLGAPDYSKIQIPKQEKWQRSMSSVTEDKERQWVDDFPLHRSACEGDSELLSRLLSERFSVNQLDSDHWAPIHYACWYGKVEATRILLEKGCNPNLLNGQLSSPLHFAAGGGHAEIVQILLNHPTDRHITDQQGRSPLNICEENKQNNWEEAAKL 203
15 -40.300[R] KOG1595 CCCH-type Zn-finger protein  ali follow..  17  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................MCGAKSNLCSSKTLTEEFMRQKSEDGASATCLLEFAACDDLSSFKREIEENPSVEIDE------------------SGFWYCRRVGSKKMGFEERTPLMVAAMYGSMEVLNYIIATGSDVNRVSDEKVTALHCAVSGCSVEIIKILLDASASPNCVDANGNKPVDLLAKDSRFVPNQSRKA 169
16 -36.300[T] KOG0195 Integrin-linked kinase  ali follow..  17  3..............................................................................................................................................................................................................................................................................................................................................................................................................................................................DIFHWCREGNSIQVRLWLDETEHDNNLGDDHGFSPLHWVAKEGHAKLVETLLQRGSRVNATNMGDDIPLHLAAAHGHRDVVQMLIKERSDVNAVNEHGNTPLHYACFWGYDMICEDLLNAGAQVGIANKDGHTPLEKAKPSLAKRLQDLVEKSGREVKVISFKEQSWQGLKTRSRDATLSRFK.. 185
17 -33.300[R] KOG0522 Ankyrin repeat protein  ali follow..  12  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ASSTIDV-TKYGHSPVHHAVVTRDYAGLKKLLSALPKMRDPSEVQNEAASVAEETKADSIAAVIDRRDVV------NRDTALHLAVKLGDETSAEMLMAAGADWSLQNEHGWSALQEAICGREERIAMIIVRHYQPLAWAKWCRRLPRLVATMHRMRDFYMEIT. 158
18 -27.800[T] KOG2209 Oxysterol-binding protein  ali follow..  25  2.........................................................................................................................................................................................................................................................................................................................................................................................................................................................NTEAEQQLLHHARNGNAEEVRQLLETMARNESKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTALLAAAREGKTTELTALLNNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILV.... 226
19 -27.100[R] KOG0511 Ankyrin repeat protein  ali follow..  16  2......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ADKLMDKNFEELCYSCRTGDMDNVDRLISTGVNVNSVDKFDNSPLFLASLCGHEAVVKLLLQRGAVCDRDRYEGARCIYGALTDTIRDTLSYDISKAVDVKQPFATHISSMYNDEGFLKRDITFRVSNGKL.............................. 133
20 -27.000[R] KOG2505 Ankyrin repeat protein  ali follow..  10  362......................................................................................................................................................................................................................................................................................................................................................................................................................EEERKRQAEIEKEIRQSRLQEEERKKKKLAKYTEVIISNLKASNIEAFLEYLRSNDLSINFQFYPKNVHLHTSTPLHYAVTQKNAKLVAKLLRNGADPAMLNGNGKTPFEISTGNKEVKDEFLIARHELGESFFD----EAAKVGAPQSREQIQKQRQKAKTKLENQRRDKERQEELRRKEAMQKIEEQSKRDYDKLHGEGHSLGINNVRKVDE........... 572
21 -24.100[T] KOG0521 Putative GTPase activating proteins (GAPs)  ali follow..  13  336...................................................................................................................................DSADMLSLWIALQHSIGAAIQH------DSTHHSRPQSTNAPNNSLPAKRRIHWEEFLKIPGNAYCCDASINLGITLCIECSGVHRSL----------GVHYSKVRSLTLDAWESENVKVMMELG-----------------NEVVNRIYEARIGDDCGLKKPTEQCEIGVREAWIKAKYVERRFVCGMPKPQELLASETAEVLSIDSGGVVEDGESGGSGIAKRAT-----LSLGGTRKWAVKKLRRRQKQRSIPKTLSDDPSIYNTAKTGDELEDDDDDESINIPSMSLSISRDDLLVIGDDLALDRLETPGILGSDQESTDGESDA-----ESPEELPFSQLDANQLLYMASVVHNLPVMCMAFALGADKMWKQDRQRSFLHQAVISGSVMACEFLLLNGAAIDAVDEMGYSALHISTAKGHIAQVYLLLKHKAAYDLSSSDGKKALDIAVDQENADIVTLLRLTQLNDEIGPNDEYNGEDETYKNVMKDFSKL... 800
22 -21.400[T] KOG0818 GTPase-activating proteins of the GIT family  ali follow..  14  25.................................................................................................................................................................................................................................................................................................................................................NRGTFLCDECCS-------SLGRHISQVRHLKHTPWPPTLL--QMVETLYNNGANSIWEHSLLDPASIMSGRRKANPQDKVHPNKAEFIRAKYQMLARDDDSVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFHPEKGNTPLHVASKAGQILQAELLAVYGADPGTQDSSGKTPVDYARQGGHHELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQMADSSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDE................................ 288
23 -16.700[T] KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains)  ali follow..  13  391.......................................................................................................................................................................................................................................................................................................................................................................................................................VSATGQTWHFEATTYEERDAWVQAIQSQILASLQSCESSKSKSQLTSQSEAMALQSIQNMRGNAHCVDCETQNPKWASLNLGVLMCIE---SLGTRLSELDDWPVELRKVMSSIGN-DLANSIWEGSSQLPCTELSLGQQLLRATADEDLQTAILLLAHGSREEVNEGDGCTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 655
24 -10.700[MOT] KOG1550 Extracellular protein SEL-1 and related proteins  ali follow..  8  175..........................................................................................................................EEESQSQNDEDQLLDVIT--LRTMVKRERKRGDKELEKERRAAESAAEEAMAMLLKLRMEKSVVEMETKQYKRVAEQKQQEVIQSLQWKLDDDEDKIQINYGDDEEYGGGGSTMRILSYDLNSGGDDNGVGESSDFDEFGESEPKSEEELDPGSWRSIFEPDDSTVQAASPQYYSGLKK---------ILSAASEGNFRLMEEAVDEIEAASSAGDPHAMGFVYGIGMMREKSKSKSFLHHNFAAAGGNMQSKMAL----AFTYLRQDMHDKAVQLYAELAETAVNSFLISKDSPVVEPTRIHSGTEENKGALRKSRGEEDEDFQILEYQAQKGNANAIGLFYYFGLRLRRDHTKALHWFLKAVDKGEPRSLGEIYARGAGVERNYTKALEWLTLAAKEGLYSAIGYLYVKGYGVDKKNTKAREYFEKAVDNEDPSGLGVLYLKGIGVNRDVRQATKYFFVAANAGQPKALAKMFHTGVGLKKNLEMATSFYKLVAERGP......... 717
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.