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Query: [G] KOG0523 Transketolase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASTSSLALSQALLARAISHHGSDQRGSLPAFSGLKSTGSRASASSRRRIAQSMTKNRSLRPLVRAAAVETVEPTTDSSIVDKSVNSIRFLAIDAVEKAKSGHPGLPMGCAPMAHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLLYALLHLAGYDSVQEEDLKQFRQWGSKTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEVVDHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTENVDQRFEALGWHVIWVKNGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALGEKEVEATRNNLGWPYEPFQVPDDVKSCLDDLLFDLHFSSHWSRHTPEGATLESDWSAKFAAYEKKYPEEASELKSIITGELPAGWEKALPTYTPESPGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTLLKAFGDFQKATPEERNLRFGVREHGMGAICNGIALHSPGLIPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSILALSRQKLPHLPGTSIEGVEKGGYTISDDSSGNKPDVILIGTGSELEIAAQAAEVLRKDGKTVRVVSFVCWELFDEQSDEYKESVLPSDVSARVSIEAASTFGWGKIVGGKGKSIGINSFGASAPAPLLYKEFGITVEAVVDAAKSFFLast
1 -219.000[G] KOG0523 Transketolase  ali  100  1MASTSSLALSQALLARAISHHGSDQRGSLPAFSGLKSTGSRASASSRRRIAQSMTKNRSLRPLVRAAAVETVEPTTDSSIVDKSVNSIRFLAIDAVEKAKSGHPGLPMGCAPMAHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLLYALLHLAGYDSVQEEDLKQFRQWGSKTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEVVDHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTENVDQRFEALGWHVIWVKNGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALGEKEVEATRNNLGWPYEPFQVPDDVKSCLDDLLFDLHFSSHWSRHTPEGATLESDWSAKFAAYEKKYPEEASELKSIITGELPAGWEKALPTYTPESPGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTLLKAFGDFQKATPEERNLRFGVREHGMGAICNGIALHSPGLIPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSILALSRQKLPHLPGTSIEGVEKGGYTISDDSSGNKPDVILIGTGSELEIAAQAAEVLRKDGKTVRVVSFVCWELFDEQSDEYKESVLPSDVSARVSIEAASTFGWGKIVGGKGKSIGINSFGASAPAPLLYKEFGITVEAVVDAAKSFF 754
2 -184.000[G] COG0021 Transketolase  ali follow..  48  1................................................................................MSQLANAIRFLSADAVQKANSGHPGAPMGMAEMAETLWTKFLNHNPANPKFYNRDRFVLSNGHASMLLYSLLHLTGYN-LSIEDLKNFRQLHSKTPGHPEYGYTDGVETTTGPLGQGIANAVGMALAEKILAAEFNKDGLNIVDHYTYVFMGDGCLMEGVSHEACSLAGTLGLGKLIVLYDDNNISIDGKVDGWFTENIPQRFESYGWHVVPNV-NGHDTAAIQAAIEAARAETGKPSIICCKTLIGKGSANKEGSHKTHGAPLGADEIEATRKHLGWTYPAFEIPQEIYDAW--------------NAKEQGAKLEAEWNELFAQYQTKYPAEAAEFVRRMDKKLPDNFDEYVKEVCAKAETIATRKASQNSIEILAKELPELVGGSADLTPSNLTDWSNSVSV-TRDKGGNYIHYGVREFGMGAIMNGLVLHG-GVKPFGATFLMFSEYERNALRMAALMKINPVFVFTHDSIGLGEDGPTHQPIEQTATLRLIPNMDVWRPCDTAESLVAWAEAVKAADHPSCLIFSRQNLKFQARQQLNDIKRGGYVISE--AQGNAQAVIIATGSEVELALEAQKALAAQNIAVHVVSMPSTNVFDRQDTAYQAAVLPES-LPRIAVEAGHADGWYKYVGLNGAVVGINRFGESAPADLLFKAFGFTVDNVVDTVKSVL 659
3 -140.000[C] COG2609 Pyruvate dehydrogenase complex, dehydrogenase (E1) component  ali follow..  19  1MSAVPEQVLGATRASDVDPQETKEWLEALQGVIG-AEGPDRAAFLLDKQLEYARINGVTSPLHAETPYINTIPVENDQEIEHRIRSFTRWNAMAMVRANKDTNVGGHISSFASAATLYDVGYNHFWHAPSDKHGGDMVFVQGHSAPGVYSRAFLLGR--LSEDQLDSFRQEVDGISSYPHPWMPDFWQFPTVSMGLGPIMAIYQARFTKYLASRSLIQNFE--NRKVWAFLGDGETDEPESLGAIGMAGREKLDNLVFVINCNLQRLDGPVNGKIIQELESEFRGAGWNVIKVIWGGHDPHKIFAAFKSATEHKGQPTVILAKTIKGYGMGEAAMNIAHQQKKMPVDAIRKLRDRFNIPVADDQLEHVPYVKF--------------------EEGSKELEYMRRARMDLGGYLPARRQKADALQVPALAADALLKATGEGREVSTTMAFVRILNILLKDGKHVVPIVPDESRTFGME-HDQLMFYKESQTGQVLQEGINEAGAMCDWIAAATHGVAMIPFYIYYSMFGIQRIGDWAAGDMRSRGFLLGGTAGRTTLNGEGLQHEDGHSHVYHAAIPNCISYDPTFQYELAVVMQDGLRRMYVEYYLTVMNENHPEMPAGAEADIIKGMYLFKKGENSNAPRVQLLGSGTIFREVIAAAELLKKDGVESDLWGCPSFTELAREGNAHVEKMLKGVRGPVIASTDYVRTQIRAFVPRRYVVLGTDGFGRSDTREKLRHFFEVDRYWVTVASLKAL 866
4 -107.000[G] COG3957 Phosphoketolase  ali follow..  13  1...............................................................MSTVPAKGPLTPQQLSLINRYWRAANYLSVGQIYLMKNPLLREPLQPEHIKPRLLGHYAHLNRIIQQRNANVIYICGPGHGGPGMVANTYLEGTYSAGMERLFRQFSFPGGIPSHAAP-ETPGSIHEGGELGYALVHAYGAAFDNP--------------DLVVACVVGDGEAETGASWHSNKFLNPARDGAVLPILHLNGYKIANPTVLARLDDLDNLFRGYGYEPFFVE--GSEPADMHQKMAATLDTIFQRIMIILRSPKGWTGPKTENYWRAHQVPVANCRENDAHRKILEDWMKSYDPSDLFDE--------------GALKPELRALAPKGEARIGANPHANGGLLRK-----ELHMPDFRQYAVNVTEPGAIEAQSTKILGDFLRDVMKLNENFRIFGPDETASNRLGMAETLDMDDHLAADGRVMEVLSEHLCQGWLEGYLLS--GRHGFFSCYEAFIKWLQVARELEWRKPSSLNYLLTSHVWRQDHNGFSHQDPGFVDLVKSADIARVYFPPDANTLLWVGDHCLKTWNRVNVIVAGKQPEPQWLTMAEAEKHCEAGLGAGTEDGLEPDIVMACAGDVPMETLAAVDLLRQSLPHLRIRVVNVVDLMVLQSPHQHPHGISDEEDRMFTTNRPVIFAYKRTNHSNFHVRGFIEQGTTTTPFDMTVLNELDRFHLAMEAVERL 748
5 -90.800[HI] COG1154 Deoxyxylulose-5-phosphate synthase  ali follow..  15  4........................................................DIAKYPTLALVDSTQELRLLPKESLPKLCDELRRYLLDSVSRSS-GHFASGLGTVELTVALHYVY----------TPFDQLIWDVGHQAYPHKILTGRRDK-------IGTIRQKGG-LHPFPWRGESEYDVLSVGHSSTSISAGIGIAVAAEKEGK----------DRRTVCVIGDGAITAGMAFEAMNHAGDIRPDMLVILNDNEMSISENVGAL--NNHLAQLLSGKLYSSLREGKKVFSGVPPIKELLKRTEEHIKGMVVPGTLFEELGFNYIGPVDGHDVMGL-ISTLKNMRDLKG-----------------------PQFLHIMTKKGRGYEPAEKDPITFHAVPKFDPSSGC-------------------LPKSSGGLPGYSKIFGDWLCETAAKDSKLMAITPAMREGSGM------VEFSRKFPDRYFDVAIAEQHAVTFAAGLAIG--GYKPVVAIYSTFLQRAYDQVIHVAIQKLPVMFAIDRAGI-VGADGQTHQGAFDLSYLRCIPDMVIMTPSDENECRQMLFTGYHYNDGPTAVRYPRGNAQVALTPLEKLPIGKGLVKRHGE-----KLAILNFGTLMPEAAKVAE-----ALNATLVDMRFVKPLDDTLIL-----MAAQHDALVTLEENAMGGAGSGVPVPVLNIGLDFFIPQGTQEEARAELGLDAAGIEAKIKAWL 619
6 -85.700[G] COG3959 Transketolase, N-terminal subunit  ali follow..  27  9..............................................................EKGGGSDGTPISIEELDKLRQVAEKARRNVIKMLFYDQTIHVGSSLSSIEILTTLIFKHIRTD---SSLVNKDWLILSKGHAAPALYAVLAEKGY--IKEEELWRIQDITGLLQGHPET-FIPGVDMSTGSLGQGLSFGIGVATGIKM----------ANGTGRVYVIMGDGEQDEGEIWEAMTHAVVRNLDNLIAFIEMNNFQLDGSTDIKPKNFLPKVWEAVGWKVLNCD--GHDFISITNAVNEAYK-ASKPVVIFAKTVRGKGFPPIENTHKQRSSPDDARKYLLN.................................................................................................................................................................................................................................................................................................................................................................................................................. 280
7 -56.300[G] COG3958 Transketolase, C-terminal subunit  ali follow..  18  7.....................................................................................................................................................................................................................................................................................................................................................................................................................................................AGLKDDIEMRKVYAGFIAGQIEAGSPIIALEADLMSSMAM------DSVARDYPQHVINCGIMEANVIGTAAGLALT--GRKPFVHTFTAFASRCFDQLFMADYQRNNVKVIASDAGVTACHNGGTHMSFEDMGIVRGLAHSVVLEVTDAVMFADILRQLM-DLDGFYWLRTIRKQARSIYAPGSTFTIGKGNVLREGD-----DITLIANGIMVAEALEAARQLEQEGVSAAVIDMFTLKPIDRMLVK-----YAEKTRRIVTCENHSHNGLGSAVAEPMRRVGVERYGQVGTQDFLQKEYGLTAEAIVEAAKSLL 317
8 -21.200[C] COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit  ali follow..  15  11.........................................................................................................................................................................................................................................................................................................................................................................................................................................................VMTTVREALRDAMAEEMRADEKVFVMGEEVAEYQGA-YKITQGLLQEFGERRVIDTPITEHGFAGIGVGAAMT--GLKPIVEMTFNFAMQAIDQIMSGGQMGAPMVF---RGPSGAAARVGAQHSQCYAAWYSHIPGLKVVMPYTAADAKGLLKAAIRDPNPVIFLILYGQSFEVPKLDDFVLPIGKARIHRKGK-----DATIVSFGIGMTYAIKAVAELEKLGIDVELIDLRTIRPMDLPTV----ESVKKTGRLVTVEEGFPQSSVGDFIANQVMRAAFDYLDAP--AANLEKLALPNVDEVVQAVKTVC 333
9 -19.200[C] KOG0524 Pyruvate dehydrogenase E1, beta subunit  ali follow..  13  33......................................................................................................................................................................................................................................................................................................................................................................................................................................................NGVKEMTVRDALNSAMEEEMKRDDRVFLIGEEVAQYNGA-YKISRGLLDKFGPKRVIDTPITEMGFTGLATGAAFA--GLRPICEMTFNFSMQAIDHIMSGGIQACPIVF---RGPNGPAAAVAAQHSQHFAPWYGSIPGLKVVSPYSAEDARGLLKAAIRDPN---VVVLENEILYGKTFPISKEALSEDFVLPFGLAKPGKDITIVGESISVVTALEAADKLADYGVEAEVINLRSIRPLDINTI----ASVKKTNRIVTVDQAYSQHGIGSEIAAQIMVERVSMADVPMPYSHPVEAASVNADVVVAAAKKCL 363
10 -18.500[C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit  ali follow..  18  1....................................................MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPFVISCQGQEAAQVGAAFALD----------------REMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNSGGRQMPGH--GQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKK----------DIAAFVTFGEGSSNQGDFHEGANFAAVHKL--VIFMCENNKYAISVPYDKQVAENISDRAIGYGMPGVTVN--GNDPLEVYQAVKEARERGEGPTLIETISYRLTPHSSDDDDSSYR----GREEVEEAKKS............................................................................................................................................................................................................................................................................................................................................................................................................... 273
11 -16.500[C] KOG1182 Branched chain alpha-keto acid dehydrogenase complex, alpha subunit  ali follow..  11  45.TAYLSPFGSLRHESTAVETQADHLVQQIDEVDAQELDFPGGKVGYTSEMKFIPESSSDEDGRIIPDSDFIPVSEKLAVRMYEQMATLQVMDHIFYEAQRQGRISFYLTSVGEEAINIASAAALSPDD-----REPVLLWRGFTLEEFANQC---------------FGNKADYGKGRQMPIHYGSNRLNSSPIATQLPQAAGVGYSLKMDKK----------NACTVTFIGDGGTSEGDFHAGLNFAAVMEA--VVFICRNNGWAISTHISEQFSDGIVVKGQAYGIRSIRVD--GNDALAVYSAVRSARETEQRPVLIEMMTYRVGHHSTSDDSTKYRAADMSRNPVNRFRKWV---EDNGWWSEEDESKLRSNARKQLLQAIQAAEKWEKQPLTELFNDVYDVKPKNLEEQELGLKELVKK.......................................................................................................................................................................................................................................................................................................................................... 461
12 -15.600[C] KOG0225 Pyruvate dehydrogenase E1, alpha subunit  ali follow..  14  1.......MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTREDGLKYYRMMQTVRRMELKADQLKQKIIRGFCHLCDGQEACCVGLEAGIN-----------------PTDHLITARAHGFTFTRGL----------LAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALACKYNGK----------DEVCLTLYGDGAANQGQIFEAYNMAALWKL--CIFICENNRYGMGTSVERAAAST---DYYKRGDFIPGLRVDGMDILCVREATRFAAASGKGPILMELQTYRYHGHSMSDPGVSYR----TREEIQEVRSK............................................................................................................................................................................................................................................................................................................................................................................................................... 313
13 -12.200[C] COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes  ali follow..  12  187................................................................RIESVVGKPTFSDAEKRRFLSELTAAEGLERLGAKFPGAKRFSLEGGDSLVTMLKEMIRHAGKN----GTREVVLGMAH-----------RGRLNVLINVLKKPEDLFDEFAGKHKEHLGTGVETEGGLVHLALAFIVSPVVIGSVRARRDRLDEARSNMVLPITIHGDAAITQGVVQETLNMSQGYEVGGTVRIVINNQIGFTTSNSTQYCTDIAKMVQAPIFHV-----NADDPEAVAFVTRLAHNEADEPSA--TQPVMYQKIKKHPTPRKIYADKLIEQNIASLEDATEMVNLYRDALDHGDCVVEEWRPMNLQSFTWSPYLNHEWDEAYPSKVEMKRLQELARRISSAPEAIEMQSRVAKIYSDRALMASGEKPFDWGGAETLAYATLVDEGIPIRLSGEDAGRGTFFHRHAVSNIHSGQGDFQVWDSVLSEEAVLAFEYGYATAEPRTLTI-AQFGDFANGAQVVIEQKWGRMCGLVMLLPH---GYEGQGPEHSSLERYLQLCAEQNMQVCIPSTPAQVYHMIRRQALRGMRRPLIVMSPKSLPLATSSLDELANGSFLPAIDELDPKGIKRVVMCSGKVYYDLLEQRRKNGQTDVA--IVRIEQLYPFPHQAVQSVLEQYAHVHDFVWCQEEPLNQGAWYCSQHNFREV-AGRPASASPAVGYLSVHQKQQQALVNDALNV. 934
14 -9.920[C] COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, alpha subunit  ali follow..  9  10..................................................................................................................................................................................................................................................................................................................................................................................................................................................................NTAAAHISYAFTDVAAI--PITPSSPMHVDEWATQGRKNLFGQKVKIMEMQSEAGAAGAVHGSLQAGALTTTYTASQGLLLMIPNMYKIAGELLPGVFHVSARALA-THSLNIYGDHQDVMAARQT-GCALLAEGSVQEVMDLSAVAHIKGRVPFINFFDGFRTSHEIQGEISKITGREYHLFNYYGAEDADRVIIAMGSICDTIEETIDYLRAKGEKVGVLKVHLYRPFSVEHF---LKYIPKTAKKIAVLDRTKEAGSQAEPLYLDVVKAFYNSDVRPVIVGGRFGLGTLPVHIYSVYENLK 381
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.