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Query: [J] KOG0556 Aspartyl-tRNA synthetase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSEMEKQVENLSLEAKNEKPKEVILGEDGKPLSKKALKKLEKEREKEQKRKEREAREAEEKKKREANEIDYSAGKYGDLPLNRSTARPGRTYTQISDISAKNDGQTVLLRARVYTSRLQGNKMCFFSLRQKYDTIQALAVVNKDTISKQMVKWCGSISLESIVLVEGIVKKSPEIIKSATVQDAEIHISSIYVISPIKKNLPFLVEDAGRSEEQIRESEENAAEGDSKFVRVNLDTRLDNRVLDLRTPTNQAIFDIQAGICQAFREFLLSNSFNEIHTPKMSGASSEGGSNVFKIQYFKTDGFLSQSPQLYKQMLIAADRERVFEIGPVFRAEDSNTYRHMTEFTGLDLEMAFNEHYHEVMEFIEKLFLYIFKTIREKYAKQVAVVRQQYPSEDFILPDADRIRFHFKDAVKLLKEAGYRKQLVPGQKVPEDEEFHYCEDPEFDDFSTPEERALGQIVREKYHTDFYVIDKYPSSVRPFYTMPDPEDPRYSNSYDFFMKGQEIMSGAQRIHDPELLVERMKALGVSPDVGLQQYIDAFAIGCPPHAGGGIGLERVVMFYLNLPNIRLASSFPRDPKRLLPLast
1 -175.000[J] KOG0556 Aspartyl-tRNA synthetase  ali  100  1MSEMEKQVENLSLEAKNEKPKEVILGEDGKPLSKKALKKLEKEREKEQKRKEREAREAEEKKKREANEIDYSAGKYGDLPLNRSTARPGRTYTQISDISAKNDGQTVLLRARVYTSRLQGNKMCFFSLRQKYDTIQALAVVNKDTISKQMVKWCGSISLESIVLVEGIVKKSPEIIKSATVQDAEIHISSIYVISPIKKNLPFLVEDAGRSEEQIRESEENAAEGDSKFVRVNLDTRLDNRVLDLRTPTNQAIFDIQAGICQAFREFLLSNSFNEIHTPKMSGASSEGGSNVFKIQYFKTDGFLSQSPQLYKQMLIAADRERVFEIGPVFRAEDSNTYRHMTEFTGLDLEMAFNEHYHEVMEFIEKLFLYIFKTIREKYAKQVAVVRQQYPSEDFILPDADRIRFHFKDAVKLLKEAGYRKQLVPGQKVPEDEEFHYCEDPEFDDFSTPEERALGQIVREKYHTDFYVIDKYPSSVRPFYTMPDPEDPRYSNSYDFFMKGQEIMSGAQRIHDPELLVERMKALGVSPDVGLQQYIDAFAIGCPPHAGGGIGLERVVMFYLNLPNIRLASSFPRDPKRLLP 580
2 -122.000[J] KOG0555 Asparaginyl-tRNA synthetase  ali follow..  22  7....DTDAGSDQHPGTEAQPLATLVGESWEPAAKAAIKKAVKKYEAEVKKLEKAGCREKEAEEAQHAALE----EAKKITFSLDKSLPEAKVIKIGES-VQHRDQRVSIKAWVHRLRRQGKSLMFLVLRDGYGFLQCVLNDKLCQS-----YDAVTLSTETSVQVYGIIKALPDGKSAP--DGHELTVDYWEVIGKAPAGGIDNVLNE----------------------SAGVDVMLDNRHLVIRGENASRILRIRAAATRAMRDHFFAAGYTEVAPPTLVQTQVEGGSTLFGLDYYGEPAYLTQSSQLYLE-TCNAALGDVYCISQSYRAEKSRTRRHLSEYQHVEAECAFIT-FDQLMDRIEALVCDTVDRLLADPVTKSLIEFVN---PGYKAPARPFKRMPYKEAIEWLQKNDVRNEMGE------------------KFVYGEDIAEAAERRMTDTIGVPILLNRFPHGIKAFYMPRCADDNELTESVDLLMPGGEIVGGSMRIWKEDQLLAAFEKGGLDSKN-YYWYMDQRKYGSVPHGGYGLGLERFICWLTDTNHIRDVCLYPRFVGRCAP 545
3 -119.000[J] COG0017 Aspartyl/asparaginyl-tRNA synthetases  ali follow..  29  2...........................................................................................KTTIKQA-KDHLNQDVTIGAWLTNKRSSG-KIAFLQLRDGTGFMQGVVVKSE--VDEEVFKLAKEIAQESSLYVTGTITEDNRSD-----LGYEMQVKSIEVISEAHDYPITPKN-------------------------HGTEFLMDHRHLWLRSKKQHAVMKIRNEVIRATYEFFNKDGFTKVDPPILTASAPEGTSELFHTKYFDQDAFLSQSGQLYLEAAA-MAHGKVFSFGPTFRAEKSKTRRHLIEFWMIEGEMAFTN-HAESLEIQEQYVTHVVKSVLENCKLELKILERDTSKL--EKVATPFPRISYDDAIEFLKAEGFDD------------------IEWGEDFGAPHETAI-----ANHYDLPVFITNYPTKIKPFYMQPNPENEETVLCADLIAGYGEIIGGSERVDDLELLEQRVKEHGLDEEA-YSYYLDLRRYGSVPHCGFGLGLERTVAWISGVEHVRETAPFPRLLNRLYP 430
4 -118.000[J] KOG0554 Asparaginyl-tRNA synthetase (mitochondrial)  ali follow..  19  32..........................YSLFRPLRRRVLPPFDAFPANSRRRCFCTAVSESLGSGDGNKVESYEKRFGSKVGEFRKKLRIAEVKGGADEGLSRVGQSLNIMGWVRTLRSQS-SVTFIEINDGSCNLQCVMTSD---AEGYDQVESGSILTGASVSVQGTIVASQGTKQK-----VELKVEKIIVVGECDSSYPIQKKRV------------------------SREFLRTKAHLRPRTNTFGAVARVRNTLAYATHKFFQESGFVWVASPIITASDCEGAGEQFCVDFFGKPAFLTVSGQLNGE-TYATALSDVYTFGPTFRAENSNTSRHLAEFWMIEPELAFAD-LDDDMACATAYLQYVVKYVLDNCKEDMEFFDTWIEKGLSDVAEKEFLQLGYTDAIEILLKANKKFDFPVK---------------WGLDLQSEHERYITE---EAFGGRPVIIRDYPKEIKAFYMRENDDGKTVAAMDMLVPRIGELIGGSQREERLEVLEARLDELKLNKES-YWWYLDLRRYGSVPHAGFGLGFERLVQFVTGIDNIRDVIPFPRTPASAE. 566
5 -99.500[J] KOG1885 Lysyl-tRNA synthetase (class II)  ali follow..  19  25.RRLKAEKKVAEKEAKQKELSEKQLSQATAAATNHTTDNGVGPEEESVDPNQYYKIRSQAIHQLKVNGEDPYPHKFHV---DISLTDFIQKYSHLQP-GDHLTDITLKVAGRIHAKRASGGKLIFYDLRGEGVKLQVMANSRNYKSEEEFIHINNKLRRGDIIGVQGNPGKTKKG-------ELSIIPYEITLLSPCLHMLP-----------------------HLHFGLKDKETRYRQRYLDLLNDFVRQKFIIRSKIITYIRSFLDELGFLEIETPMMNIIPGGAVAKPFITYHLDMNLYMRIAPELYHKMLVVGGIDRVYEIGRQFRNEGIDL-THNPEFTTCEFYMAYAD-YHDLMEITEKMVSGMVKHITGSYKVTYHPDGPEGQAYDV-DFTPPFRRINMVEELEKALGMKLPETNLFETEETRKICVAKAVECPPPRTTARLLDKLVGEFLEVTCINPTFICDHPQIMSPL-AKWHRSKEGLTERFELFVMKKEICNAYTELNDPMRQRQLFEEQAKAKAAGDENFCTALEYGLPPTAGWGMGIDRVAMFLTDSNNIKEVLLFPAMKPE... 576
6 -97.500[J] COG1190 Lysyl-tRNA synthetase (class II)  ali follow..  21  3.....................................EQKPQVAEQAQELNSELQARREKLAVLRGKG-IAFPNDFRR---ENLSDQLHAEFDSKENEELEALNIDVTVAGRMMTRRIMG-KASFVTLQDVGGRIQLYVSRDDLP-EGVYNEEFKKWDLGDILGARGKLFKTKTG-------ELSIHCSELRLLTKALRPLP-----------------------DKFHGLADQETRYRQRYLDLANDESRHTFKVRSQVMSGIRSFMVEKGFMEVETPMMQVIPGGASARPFVTHHLDIDMYLRIAPELYLKRLVVGGFERVFEINRNFRNEGVSP-RHNPEFTMMELYMAYAD-YKDLIVLTEELFRTLTETILGSSVVQYGEQTFDF--------GKPFAKLTMKEAICKYRPETNV-ADLDDMDKAVAIAESLGIKVEKSWGLGRIQCEIFEETAESHLIQPTFITEYPAEVSPL-ARRNDDNPFITDRFEFFIGGREIGNGFSELNDAEDQAQRFADQVSAKEAGDEDYITALEHGLPPTAGLGIGIDRMVMLFTNSHTIRDVILFPAMRPV... 504
7 -93.300[J] COG0173 Aspartyl-tRNA synthetase  ali follow..  21  5.............................................................................................YCGLISEQYLDQTVTVKGWVHRRRDHG-GVIFIDLRDREGIVQVVIDPD----TPEAFAAADSSRNEYVLSITGRVRNRPEGTTNDKMGKIEILAKEIEVLNAAATPPF-----------------------QIDDENISENVRLTNRVIDLRRPVMQRNLRLRYQVAMGVRRYLDAQGFIDIETPMLTRSTPEGARDYLVPSRVHPGEFLPQSPQLFKQLLMVAGFDRYYQITKCFRDEDLRADRQ-PEFTQIDLETSFLN-EDEIMDITEGMAKQVFKDALNV-------------------DLGDFPRMPYSEAMFYYGSDKPDMRINLKFTELTDLMKTEEFKVFRGAADMKGLEHGKDNGYFTDEWKPLWVVDFPAVHHPFTAMVSDPANCLARAYDMVLNGWEIGGGSIRIHRADVQEKVFAALKISPEEQFGFLLDNLKFGAPPHGGLAFGLDRLVTLMTGAESIRDVIAFPKTQRAQCL 572
8 -70.200[J] COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II)  ali follow..  18  1....................................................................................................................................................................................MSQLSLAFCSERV--QFVISVS-----------------------CDEPPMTNSD---------WMPTASISQLKQRATLLRQIREFFAERNVLEVETPAMSHATVHTFKTEFVGPGKGSALHLMTSPEFHMKRLLAAGSGCIYQLGKAFRNEENGR-YHNPEFTMLEWYRIGFD-HHALMDEMDALLQLVLRCG-------------------------SAERMTYQEAFLNVLGVCPLEEEMRELKQVAATLGLSDIAEPEEDRDTLLQLLFSIGIEPKIGITPAFVYDFPASQAAL-AKINPADPRVADRFEVYFKGIELANGFHELDNPAEQLARFKADNAKRLEMDYHLIAALEAGLPECAGVALGIDRLIMLALGEDHIDKVTAFPFPRA.... 349
9 -65.700[J] KOG2411 Aspartyl-tRNA synthetase, mitochondrial  ali follow..  22  1.........................................................................................................................................................................................................................................................MQYNLRLRSQMVMKMREYLNLHGFVDIETPTLFKRTPGG-AKEFLVPS-GKFCSLPQSPQQFKQLLMVGGLDRYFQVARCYRDEGSRPDRQ-PEFTQIDIEMSFVD-QTGIQSLIEGLLQYSWPNDKDP-------------------VVVPFPTMTFAEVLATYGTDKPDTRFGMKIIDISDVFRNTEIGFLQDALSADLLETRGVVLRDPTLFSFLWVVDFPLFLPPF-LLYTEPKKARSQHYDLVLNGNEIGGGSIRIHNAELQRYILATLLKEDVKMLSHLLQALDYGAPPHGGIALGLDRLICLVTGSPSIRDVIAFPKSFR.... 427
10 -54.500[E] COG2502 Asparagine synthetase A  ali follow..  16  5.....................................................................................................................................................................................................................................................FILQQQEISFVKNTFTQNLIEQL---GIIEVQGPILSQVGNEKAVQVNVKCIPNAVFEVVHSLAKWKRHTLAEDEGLFVHMKALRPDEDSLDPTHSVYVDQWDWEKVIPEG-RRNFAYLKETVNSIYRAIRLTELAVEARFDIPSILP---------KQITFVHSEDLVKRYP-------------DLSSKERENAICKEYGAVFLIGIGGKLSDGKPHD-GRAPDYDDWTTESENGYKGLNGDILVWNDQLGKAFELSSMGIRVDE-SALRLQVGLTGDEDHLKMDWHQDLLNGKLPLTIGGGIGQSRLAMLLLRKKHIGEVSVWPKEMLEEFS 327
11 -13.300[S] COG3111 Uncharacterized conserved protein  ali follow..  17  43........................................................................................NGSVTTVESAKSLRDDTWVTLRGNIVERISDDL----YVFKDASGTINVDIDHKR-----------VTVTPKDTVEIQGEVDK--------DWNSVEIDVKQIRKVNP................................................................................................................................................................................................................................................................................................................................................................................................ 130
12 -12.600[J] COG0016 Phenylalanyl-tRNA synthetase alpha subunit  ali follow..  10  1..........................................................................................................................................MREQLEALRDDAIKKIEQAQEKKVVQEIRVKYLGKKGPVTEVLRGMKLSPEERPVIGQLANDVREAIGKA--------------ESKMEALEQAEIHRKLQEETIDVTLPGRPGGAHPLTATITEVEDLFIGLGFSVAEGPQIETDKDHPARDMQDSFYFTDELLLRTQTSPVQARTMEKYKGKIICPGKVFRRDDDDAT-HSHQFMQIEGLYVDHGRMSDLKGVLQAFAKSFFGE----------------------------RSIRLRPSF------------------------------------------------------------FPVEVDVSCGICHGDGCRVCKQTGWI----EILGAGM------VHPRVLEMSGFNPNE-----------------AFGMGVERLSMLKYGIDDIRHF............ 330
13 -12.100[J] KOG1936 Histidyl-tRNA synthetase  ali follow..  9  71.............................................................................................................................................................................................................................................................MVVREKILDLVISCFKRHGAKGMDTPAFTEKYGEDSGLMYDLDQGGELLSLRYDLTVPFARYLAMN--KRYHVGKVWRRESPTIVQRYREFCQCDFDIAGQFD--ECLKIMCEILSGL----LGDFLIKVNDRRIVDGMFAVCGVPESKFR-AICSSIDKLDKMAWKDVRHEMVVKKGLAPEVADRIGDYVQCHGGVSL-VEQMFQDPRLSQNKQALEGLGDLKLLFEYLTLFGIADKISFDLLARGLDYYTGVI----YEAVLLQTPTQAGEEPLNVGSVAAGGRYD-VPCVGLSIGVERIFYIVEQRMKTKG............. 402
14 -12.100[J] COG0124 Histidyl-tRNA synthetase  ali follow..  11  17.............................................................................................................................................................................................................................................................VETWQWIEQKAYDLCRRYNYQEIRVPMFEHTELFLRGVGDTTDIVQKEMYLTLRPEGVTRAYVSNKL-KLFYIGPMFRYERPQSGRM--QFVQFGVEALGSAD--EVLALVMRFYEEL-----------LKNLKLVINSLGDTDSRLAHREALVNHFKPRIHEFCNDCQDRLEKNPLRILDCKKDRDHELMGTAPSIHDYLSTESKAYFEKVQSYLTALNIPFV---------DATLVRGLDYYNH--EVMVDGEGFG---------AITTLCGGGRYNGLVEEIGGPETPGIGFALSIERAIMAL..................... 317
15 -11.800[J] KOG2784 Phenylalanyl-tRNA synthetase, beta subunit  ali follow..  11  53..................................SSFEMTAETDVRSTENLPQQILDFLQESNEFNSIQLAQQWNLDHQKVIGAIKSLLANEGVLTTKDVTEKRLELTNEGVQFANEGSPEYLVFEFVGTDGAAQADIQKKPFGKIGMAKAMQFKWVSVDKGRVVRQATEVTDSTRKQLESLRIGSSDVSENEKKELKKRKLISEVNIKALVVSKGTSFTTSLAKQEADLTPEMIASGSWKDMQFKKYNFDSLGV--MKVRSEFRQIFFSMGFSEMATDALFQPQQHPARDAHDTFFVSDPAISTKFPEDYLERVKTVHSKKLFSIDRVFRNETLDAT-HLAEFHQVEVIAEKNLSLAHLIGIFTEFFKKLGIT-----------------------------NLRFKPTY------------------------------------------------------------NP------YTEPSME---IFAYHQGLTKWVEIGNSG--MFRPEMLLP---------------------MGLPAD-GYGLSLERPTMIKYGINNIRDL............ 532
16 -9.800[E] COG3705 ATP phosphoribosyltransferase involved in histidine biosynthesis  ali follow..  8  18.............................................................................................................................................................................................................................................................ARQLESAREQLLALFRVHGYELVQPPLMEHIDAGLSLKTILVTDRLSGRQLGIRADITPQVARIDAHLRLCYAGPVLHAQSDGLLNM-REPLQAGAEMYGFADIRGDIELIDLMLKSMKIADMGKVLLSLGHIGAHLDAGQSATLLALMQDKDTETVEAQVKAWKLDGMWAKAFSLLPRLYGGREVLSDARGRLPDLSAVGGA------------LGELQAVCDAFPDCEIHIDLSELRVDNYHTGHDAVARGGR-------------------------YDGLGGFGRAPATGFSFDLRSFIGRLPAIERQPAVLV.......... 331
17 -9.070[L] COG5235 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit  ali follow..  8  42............................................................................................VTIKQILESKQDHHVCFVGVVRNITDHTANIFL-TIEDGTGQIEVRKGNDDSSGKGYGSQVAQQFEIGGYVKVFGALKEFGGKKN-DSFNEVLTHHLEVIKCHSIASGMMKQPLESASNNNGQSLFVKDDNDTSSGSSPLQRILEFCKKQCAVPIPLISQSLNLDETTVRNCCTTLTDQGFI.................................................................................................................................................................................................................................................................................................................. 261
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.