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Query: [OT] KOG0686 COP9 signalosome, subunit CSN1, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEVDGTPRRGGCKMPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNMLast
1 -125.000[OT] KOG0686 COP9 signalosome, subunit CSN1  ali  100  1MEVDGTPRRGGCKMPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM 500
2 -81.900[O] KOG0687 26S proteasome regulatory complex, subunit RPN7/PSMD6  ali follow..  20  11............................................................................LPKNPDLRIAQLRFLLSLPEHRGDAAVRDELMAAVRD----NNMAPYYEALCKSLDWQIDVDLLNKMKKANEDELKRLDEELEDAEKNLGESEIRDAMMAKAEYLCRIGDKEGALTAFRKTYDKTVALGHRLDIVFYLLRIGLFYMDNDLITRNTEKAKSLIEEGGD--------WDRRNRLKVYQGLYCVAIRDFKQAAELFLDT-VSTFTSYELMDYKTFVTYTVYVSMIALERPDLREKVIKGAEILEVLHSLPAVRQYLFSLYECRYSVFFQSLAVVEQEMKKDWLFAPHYRYYVREMRIHAYSQLLESYRSLTLGYMAEAFGVGVEFIDQELSRFIAAGRLHCKIDKVNEIVETNRPDSKNWQYQETIKKGDLLLNRVQKLSRVINM................................ 389
3 -81.100[O] COG5187 26S proteasome regulatory complex component, contains PCI domain  ali follow..  17  1.................................................MCSPSATLTHRTMTEKARTTISQAIFELSSLENKSQKALDTLFSAIRDHDLAPLYKYLSENPKT----------------SASIDFDSNFLNSMIKKNEEKLAEFDKAIEDAQELNGEHEILEAMKNKADYYTNICDRERGVQLCDETFERATLTGMKIDVLFSKIRLAYVYADMRVVGQLLEKLKPLIEKGGD--------WERKNRLKAYQGIYLMSIRNFSGAADLLLDC-MSTFSSTELLPYYDVVRYAVISGAISLDRVDVKTKIVDSPEVLAVLESMSSLEACINSLYLCDYSGFFTLADVEVNHLKCDQFLVAHYRYYVREMRRRAYAQLLESYRALSIDSMAASFGVSVDYIDRDLASFIPDNKLNCVIDRVNGVVFTNRPDEKNRQYQEVVKQGDVLLNKLQKY--QATVMRGAFKV......................... 409
4 -70.300[J] KOG2758 Translation initiation factor 3, subunit e (eIF-3e)  ali follow..  11  2....................................................AEYDLTTRIAHFLDRHLVFPLLFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQ--------SLQQRTWLIHWSLFVFPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPICLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMG--NNAVSPYQQVIE-------KTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSG...... 443
5 -62.000[O] KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11  ali follow..  13  2......................................AAAAVVEFQRAQSLLSTDREASIDILHSIVKRDI----DEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLL------DLFLDMEAATGQEVELCLESIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPK------LQATLDMQSGIIHAAEEKDWKTAYSYFYEA-FEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT.............................. 422
6 -60.600[OT] KOG1464 COP9 signalosome, subunit CSN2  ali follow..  14  1......................MSDMEDDFMCDDEEDYDLEYSED---SNSEPNVDLEKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDY----STSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPH--------PLIMGVIRECGGKMHLREGEFEKAHTDFFEA-----NYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA................................. 443
7 -60.000[O] COG5159 26S proteasome regulatory complex component  ali follow..  11  19.......................................................QYNEAEQVYLSLLDKDSSQSSAAAGASVDDKRRTSILELGQLYVTMGAKDKLREFIPHSTEYMMQFAKSKTVKVLKTL----EKFEQVPDSLDDQIFVCEKSIEFAKREKRVFLKHSLSIKLATLHYQKKQYKDSLALINDLLREFKKLDSLVDVHLLESKVYHKLRNLAKSKASLTAARTAANSIYC-------PTQTVAELDLMSGILHCEDKDYKTAFSYFFES--NLTTHNSYEKACQVLKYMLLSKIMLNLIDDVKNILNAKYTKETYQRGIDAMKAVAEAYNNRSLLDFNTALKQYEKELMGDELTRSHFNALYDTLLESNLCKIIEPFECVEISHISKIIGLDTQQVEGKLSQMILDKIFYGVLDQGNGWLYVYETPNQDATYDSALELVGQLNKVVDQLFEKASVL............................... 433
8 -41.700[O] KOG1498 26S proteasome regulatory complex, subunit RPN5/PSMD12  ali follow..  11  1..........................MADGGSERADGRIVKMEVDYSATVDQRLPECAKLAKEGRLQEVIETLLSLEKQTRTASVSTSRILVAVVKMCYEAKEWDLLNENIMLLSKRRSQL----KQAVAKMVQQCCTYVEEITDLPIKLRLIDTLRMVTEGKIYVEIERARLTKTLATIKEQNGDVKEAASILQELQVETMEKKERVEFILEQMRLCLAVKDYIRTQIISKKINTKFFQEEN-------TEKLKLKYYNLMIQLDQHEGSYLSICKHYRAIYDTPCIQAESEKWQQALKSVVLYVILA-PFDNEQSDLVHRISGDKKLEEIPKYKDLLKLFTTMELMRWSTLVEDYGMELRSTEEGEKRWKDLKNRVVEHNIRIMAKYYTRITMKRMAQLLDLSVDESEAFLSNLVVNKTIFAKVDRLAGIINFQRPKDPNNLLNDWSQKLNSLMSLVNKT---THLIAKEEMIHNLQ..................... 456
9 -39.500[OT] KOG1497 COP9 signalosome, subunit CSN4  ali follow..  11  11...................................................................ALRSQLMGLINFTGT-QADKYRQLLKTVLTNTGQELIDGLRLFVEAIVNEHVSLVISRQILNDVGSELSKLPDDLSKMLSHFTLEKVNP-----RVISFEEQVAGIRFHLANIYERNQQWRDAATVLVGIPQKQYSVECKLGTYLKIARLYLEDNDSVQAELFINRASLLQAETNS--------EELQVLYKVCYARVLDYRRKFIEAAQRYNELSYRIVDQGERMTALKKALICTVLASAGQQRSRMLATLFKDERCQHL----PAYGILEKMYLERIIRRSELQEFEALLQDHQKAATSDGSSILDRAVFEHNLLSASKLYNNITFEELGALLDIPAVKAEKIASQMITEGRMNGHIDQISAIVHFENRELLPQWDRQIQSLCYQVNSIIEKISVAEPDWMDNLN.......................... 407
10 -37.200[O] COG5071 26S proteasome regulatory complex component  ali follow..  9  1................................................MEQKPEVDYSEKFAE-----LQKSLNNLNTIDIDANLEKLLIFEKQVRQASDTSTNTKVLIYIADLLFRAGDFQGLNEQLVSLFKKHGQTYLPGIDDLKTKINLIETLRTITDGKIYVEVERARLTQLLSQIKEEQGDIKSAQEILCNEPVETYDLKEKVAFILDQVRLFLLRSDYYMASTYTKKINVKFFEKED-------VQSLKLKYYEQKIRIGLHDDAYLDVCKYYRAVYDTAVVQEDPEKWKEILENVVCFALLT-PYDNEQADLLHRINADHKLNSLPLLQQLVKCFIVNELMRWPKIAEIYGSALRSDEKGEKRWSELRKRVIEHNIRVVANYYSRIHCSRLGVLLDMSPSETEQFLCDLIAKHHFYAKIDRPAQVISFKKSQNVQEQLNEWGSNITELLGKLEKV---RQLIIKEEMMNSIQQAVAK................ 443
11 -28.200[OT] KOG2582 COP9 signalosome, subunit CSN3  ali follow..  10  7.......................................................SVEAVITSIQGLSDLSALHDLLRGAQDSEPGVNFSTLDQLDASKHSLGYLYFLEVLTCG--------------------------PVSKEKAAYEIPIIARFINSCDAGQIRLASYKFVSLCKILKDHVIALGDPLRGVGPLLNAVQSSKRLTALHPDVLQLCLQAKSYKSGFSILSDDIVEIDQPRD-----------FFLYSYYGGMICIGLKRFQKALELLYNVVTAPMHQVNAIALEAYKKYILVSLIHNGQFTNTLPKCASTAAQRSFKNYTGPYIELGNCYNDGKIGELEALVVARNAEFEEDKNLG--VKQAVSSLYKRNILRLTQKYLTLSLQDIANMVQLGAKEAEMHVLQMIQDGQIHALINQKDGMVRFLEDPEQYKSSEMIEIMDSVIQSTWNQVDMEMTVLPKESSSIKQVMCFDKNFRTIGLSKN...... 419
12 -24.800[O] KOG2581 26S proteasome regulatory complex, subunit RPN3/PSMD3  ali follow..  11  1.............................MTQDVEMKDNQTPTQSVVSAPTSTLQNLKEIAATKEVRRIARAVRLTVGLRRKLTGSVISSFLDFALVP-GSEAHTRLSSFVPKSDEHDMEVDTASSNSQAPPKHLPAELLFLIDQKKYNEAKVCSTASIARLKSVNRRTVDVIASKLYFYYSLSYELTNDLAEIRSTLLALHHSATLRHDELGQETLLNLLLRNYLHYNLYDQAEKLRSKAPRFEAHSNQQ---FCRYLFYLGKIRTIQLEYTDAKE-SLLQAARKAPVASLGFRIQCNKWAIIVRLLLGEIPERSIFTQKGME-----KTLRPYFELTNAVRIGDLELFGKIQEKFAKTFAEDRTHN--IVRLRHNVIRTGLRNISISYSRISLQDVAQKLRLPVADAESIVAKAIRDGAIDATIDHKNGCMVSKETGDTNEPQTAFNSRIAFCLNMHNEAVRALRFPPNTHREKESEEKRREMKQQEEELAKYMAEE. 482
13 -17.100[O] KOG2908 26S proteasome regulatory complex, subunit RPN9/PSMD13  ali follow..  8  1......................................................MTAQDYLNGKLAA----------------ANGPLADDWKNLKELWEKKLWHQLTVLTRSLVK------------------------KPQFVASTDMHEFYRLFVAEWELRVNPLQLVEICISIAQ--IATKDKQKSMEFLSKIGNVINKDKIVARLHTGEIEARLENKDKNGQIIDLKSIRTQIDSTQHEVDSLVGVTEVHAPFYRVSSLYLREVGDFAGYYREALRLGVEDANNLTTEQKQVHAVLLGFAALLGENVHNFGELLAHPILKSLEGTRERWIVDVLLAFNSGDLTRFFSLEGDWGGWDD----LKKQKDFLTAKIRLMAVMELATKARSVSFKEIATKCQIPFDEVEFLVMKALSKDLIRGDINQVEQVVYVTWVQPRVPQIMQMATRISAWRNDVNSMEGIVSKEAREILTQN....................... 387
14 -14.500[R] KOG2753 Uncharacterized conserved protein, contains PCI domain  ali follow..  9  57............................................................................................................................................PSWSQDVDLVLNSISSLIVVVPGEKCEPVVDSFIKNVAPQFYKGTGWASAVRVLSNLYKGYSNFHTQEKIFKALVDMCAEARLIGELECNLETLQDRFNTWKTPVEGQREILRAVHRA--------LLVDQRVDQAAKVMTALLGTYTEKDAAAARDDAMECVRTAVVDPKSFSFDH-LERLSAVKALKTSDPLMFTALELFISGTLKDYKEFVAKNPKFVTEHLKVDE--TILLKKIRLLTLMSLAEEKNEISLDELAKQLDIADETLEEFVIDAIQVNAISGKINEMARTLIVSSYQHRREQWVLLEKRLKVLIANLKQTHNNVHEVNQRIE.......................... 388
15 -14.000[L] COG5600 Transcription-associated recombination protein  ali follow..  11  2.....................................................DVDIGCYFEEKRYDDKLLDFIRYDVKTPKKTKYILQKRRSLKKQGRIKNATEELLRLANEQLKLFNRIVER-----------ETNWIIYPLWVMAKQLIRLANESSELNKDSIEECGRT--------------IHRSFTICLNDRNPRLNENKKIGCYMLEFSIYHRLSNKDMIKNLVKVLESRVNARDIPPLNAMEHKSQVVLYNYYLGYYGCLENDHERGFFHLNEAVESTGKFVLQGQMEKIMILLVPLALLTKRLYPHWDHPVIAGVITRSKRLSQVYPTLVRSVISGNLSLYEATAASHERFFLSQVVITLLREVVFTRLVQRCWQWGNDRKSIMPLKILLATKQHQLDALECRLASAIASGLLRAYLSHSNRCIVFSKKEP............................................................ 418
16 -14.000[D] KOG2688 Transcription-associated recombination protein - Thp1p  ali follow..  11  2.....................................................DVDIGCYFEEKRYDDKLLDFIRYDVKTPKKTKYILQKRRSLKKQGRIKNATEELLRLANEQLKLFNRIVER-----------ETNWIIYPLWVMAKQLIRLANESSELNKDSIEECGRT--------------IHRSFTICLNDRNPRLNENKKIGCYMLEFSIYHRLSNKDMIKNLVKVLESRVNARDIPPLNAMEHKSQVVLYNYYLGYYGCLENDHERGFFHLNEAVESTGKFVLQGQMEKIMILLVPLALLTKRLYPHWDHPVIAGVITRSKRLSQVYPTLVRSVISGNLSLYEATAASHERFFLSQVVITLLREVVFTRLVQRCWQWGNDRKSIMPLKILLATKQHQLDALECRLASAIASGLLRAYLSHSNRCIVFSKKEP............................................................ 418
17 -13.800[OT] KOG3250 COP9 signalosome, subunit CSN7  ali follow..  9  20.......................................................................................................................................................................................................................................................................LEKFCVLAKSSTGAALLDVIRQALEAPNVFVFGELLAEPSVLQLKDGPDS---------------------HFETLNLFAYGTYKEYRAQPEKFIEL----------TPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEINVRHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDGYTGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDVSLINLKKVL 230
18 -13.300[OT] KOG4414 COP9 signalosome, subunit CSN8  ali follow..  10  8..........................................................................................................................................................................................................................................................................ESAFSFKKLLDQCENQELEAPGGI---ATPPVYGQLLALYLLHNDMNNARYLWKRPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQ-----SETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQ--------QADSTTRMVLPRKPVAGALDVSFNKFIPLSEEQQLARLTDYVAFLEN............................. 209
19 -10.700[J] KOG1076 Translation initiation factor 3, subunit c (eIF-3c)  ali follow..  12  259...RKDKRKEQKTKIRKRAEDDEDGEWETVVKGHVVEKPKMFEKDAEIDVPLVLAKLLEIMSA-LQIDLLFELRDISDQHNLGTAVSVKIHFNIISAIYDLEHWALLLEVMQSMMKLLLANADIIMSESVAEEHEEYAAVERLDDEFVKLLKECDPHSNDYVSRLKDENVVKTIELVLQYFERSGTNNERCRIYLRKIEHLSTSVDVMDKLCKFIRAILAHIYHHAMHDNWFQARDLVLMSHLQDNIDAADPATRNRMMANLGLCAFRQGNVKDAHHCLVDLMVTGKPKELLINLELLECVYLVSAMLAAHEFDARRRMISKTFYQQLRSSEEHVVAAAKAMRCGNWQACANFIVNKKMNTKVWDLFYESREMLTKFIKEESLRTYLNVYTSISIPSLAQMYELPVPKVHSIISKMIINEELMASLDDPSETVGMHRSEP-SRLQALAMQFVDKVTNLVDV....................................... 835
20 -9.090[S] COG4344 Uncharacterized protein conserved in archaea  ali follow..  8  4..............................................................................................................................................................................................................................................................................................................................................................................YEKEIDELINDYDMLRVLKHFTIAHVDYAKNITRYTEIPQMRVREYLKRLKDLGLLDTSIKRTEAKLKKSAEVHKHHTYYQINKKAEAVLKEI......................................... 100
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;