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Query: [O] KOG0733 Nuclear AAA ATPase (VCP subfamily), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRRSGTSLSRDLERKIHERLVSLKDTIQQTEIEEWPVSTRRAIQFVQERDMSLRRIKKPILEKVVEKVLDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIKHPEVYQYTGIHPPRGVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSGMSGESEKKVREVFEEAKSLAPCLMFIDEIDAVTPKRESAQREMERRIVAQFLTCMDELSFEKTDGKPVLVIGATNRPDSLDSALRRAGRFDREICLTVPSQDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSVGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDSLSEASSRVVNTLLTELDGLSDRSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVLGRDERCSNFSGADLAALVREAAVTALRSAVFADIASNEPEITQHSALEPIRVTNADFELAFKNIKPSVSDRDRQKYQRLAKRWSSASTNDADLast
1 -207.000[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali  100  1MRRSGTSLSRDLERKIHERLVSLKDTIQQTEIEEWPVSTRRAIQFVQERDMSLRRIKKPILEKVVEKVLDTLKAEVEEKLASSQDLVLVDSDMEEQSDSNLMEVKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGSKRQKAEANREPPSDISLSDIGGLDDCINELLELVAMPIKHPEVYQYTGIHPPRGVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSGMSGESEKKVREVFEEAKSLAPCLMFIDEIDAVTPKRESAQREMERRIVAQFLTCMDELSFEKTDGKPVLVIGATNRPDSLDSALRRAGRFDREICLTVPSQDAREKILRTMAKGLKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSVGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDSLSEASSRVVNTLLTELDGLSDRSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDLPDAHERVEILKTLTKQTPLHEEVNLDVLGRDERCSNFSGADLAALVREAAVTALRSAVFADIASNEPEITQHSALEPIRVTNADFELAFKNIKPSVSDRDRQKYQRLAKRWSSASTNDAD 779
2 -159.000[O] KOG0730 AAA+-type ATPase  ali follow..  35  69.........INDDNSVVSLHPTTMEKLQLFRG----TILIKGKKRKDTVCIALADETCEEPKIRMNKVVRSVHQCPDVKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFLEAYRPVRKGDLFLVRGGMRSVEFKV-IETDPAEYCVVAPDTEIFCEGEPVKREDEERLDEVGYDDVGGVRKQMAQIRELVELPLRHPQLFKSIGVKPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESESNLRKAFEEAEKNAPSIIFIDEIDSIAPKREKTNGEVERRIVSQLLTLMDGLKSRA----HVIVMGATNRPNSIDPALRRFGRFDREIDIGVPDEIGRLEVLRIHTKNMKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDL-----------------------------------------EDDSIDAEILNSMAVSNEHFHTALGNSNPSALRETVVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFEKFGMSPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVREIFDKARQSAPCVLFFDELDSIATQRGNSAGDAADRVLNQLLTEMDGMNAKKTVFIIGATNRPDIIDSALLRPGRLDQLIYIPLPDEDSRLNIFKACLRKSPVAKDVDVTALA--KYTQGFSGADITEICQRACKYAIRENIEKDIENEEAMEEDMVDDEVSEIRAAHFEESMKYARRSVSDADIRKYQAFAQTLQQSRGFGS. 807
3 -141.000[O] COG0464 ATPases of the AAA+ class  ali follow..  37  71................MDGLIRTNAKTSIGEYVDIRKADWKEAKSVTFAPVAQGMQIYAPSETLKAVFMNRTVSKGD--FISTTSLRRSRERETFGKGVMFEDFFQDFFGQGFGPSFGLGEIKLQVVSTAPA----------GIVKITDMTQVELLPEAMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELFDRLGIDAPKGVLLQGPPGTGKTMLAKAVANESDAYFISINGPEIMSKYYGESERAIREIFEDAEKNAPAIIFLDEIDSIAPKRAEVTGEVERRVVAQLLSLMDGLKARK----NVIVIGATNRPEALDIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGMPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINL-----------------------------------------NEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDIGVEAPKGVLLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPSIIFLDELDSLAPIRGTSEPQVTARILNQLLSEMDGLEELRAVVVIGATNRPDIIDPALLRPGRFDELILVPVPDEGARREIFRVHTKNMALAEDVDIEKLV--SFTDQYTGADIAAVCKKAGRHALREDLHA-----------------KKVRQKHFLQAIEETGPSVTPDTMKYYEAIKGELRKRKSKEIE 759
4 -114.000[O] KOG0741 AAA+-type ATPase  ali follow..  21  72...................................LSIGQEIEVSLYTFDKAKQCIGTMTIEIDFIQQFNNQAYSVGQQLVFSFNEKLFGLLVKDIESMDPSILKGEPATGKRQKI----------------EVGLVVGNSQVAFEKAENSSLNLIGKAKTKENRQSIINFEKMGIGGLDKFSDIFRRAFAFRVFPPEIVEQMGCIHVKGILLYGPPGCGKTLLARQIGKMLNAREPVVNGPEILNKYVGESEANIRKLFADAEESGLHIIIFDEIDAICKQRGSGSTGVHDTVVNQLLSKIDGVEQLNN----ILVIGMTNRPDLIDEALLRPGRLEVKMEIGLPDEKGRLQILHIHTARMLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTK-------------------------------------------VEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTK---NSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKQAMKKIFDDAYKSQLSCVVVDDIERLLDYVP-IGPRFSNLVLQALLVLLKKAPPQRKLLIIGTTSRKDVLQEMEML-NAFSTTIHV--PNIATGEQLLEALELLGNL-KDKERTTIA--QQVKGKIGIKKLLMLIEMSLQMDPE-----------------------YRVRKFLALLREEGASPLDFD.................... 744
5 -101.000[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  28  339...................................................................................................................................IAMEPSNERFLRVNHSQTALVLGGTVSSGLPP--DLLVYRSKVPMPLQEETVNILASVLSPPLCPSA----LASKLRVAVLLHGIPGCGKRTVVKYVARRLGLHVVEFSCHSLLASSERKTSTALAQTFNMARRYSPTILLLRHFDVFKNLGSQDGSGVSFEIASVIRELTEPVSNGDSRGHQVLLIASAESTEGISPTIRRC--FSHEIRMGSLNDEQRSEMLSQSLQGVSISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINSLSDDL-----------------------------HGVDIHQASQIDNSTEKLTAKEDFTKALDRSKKRNASAGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSS-GLRKRSGVLLYGPPGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPCVIFFDELDSLAPARGASSGGVMDRVVSQMLAEIDGLSDSQDLFIIGASNRPDLIDPALLRPGRFDKLLYVGVADASYRERVLKALTRKFKLSEDVSLYSVA-KKCPSTFTGADMYALCADAWFQAAKRKVSKSDSGD--MPTEEDDPDSVVVEYVDFIKAMDQLSPSLSITELKKYEMLRDQFQGRSS.... 973
6 -93.000[O] KOG0737 AAA+-type ATPase  ali follow..  18  1.......................................................................................................MEQKSVLFSALGVGVGLGIGLASGQSLGKWANGSISAEDGLTGEKIEQELVR------QIVDGRESSVTFDEFPYYEKTRLLLTSAAYVHLKQSDISKHTR-PGSKAILLSGPADTEQVWMRQERTWTLRRHTSGNDLHSRGFDVTSQPPQSLYKVLVSISETNPIIIYLRDVEKLCQSE---------RFYKLFQRLLTKLS------GPVLVLGSEDDCQEVGEGISA--LFPYNIEIRPPEDENQLMSWKTRFEDIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSAISYHLMNNKEPEYKNGRLVISSNSLSHGLNILQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRI------RPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEEAMRKIKNEFMTHWDGLMSNDRILVLAATNRPFDLDEAIIR--RFERRIMVGLPSVESREKILRTLLSKEKT-ENLDFQELA--QMTDGYSGSDLKNFCTTAAYRPVRELIKQECLKDQERRKREEAEKNSELSMEDMKVAKSQVAASFQWNDLYGEGGSRKK--EQLSYFL. 726
7 -79.400[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  29  1.............................................................................................................................................................................................................................................................................................................................MTVTNRMEIESAYHKGEGFRSEELQLVVAEKHQNLRRLQAQRNELNAKVRMLREELLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNIDINDVT-----------------------------------PNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDQRTMLELLNQLDGFEATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIA--ELMPGASGAEVKGVCTEAGMYALRE-------------------RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK............ 405
8 -79.400[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  29  2...............................................................................................................................................................................................................................................................................................................................SLEELEAMDQS--NPGEFLERVREKIRMLNSETRILQSSTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELRPG---------------------------------DLVALHKDTNIVFEKLPPDYDMKVGGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLNIKPPKGVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPTIIFIDEIDAIGAKRSDSDQTGDQRTMLELLNQLDGFSSSEEVKIIAATNRVDILDPALLRSGRLDRKIEFPLPNTLGRKRILQIHARKMSVRDDVNFDELA--RSTEGFNGAQCKAVCVEAGMAALRK-------------------EKTEISQNDFMDGIQEVLSRKKSK..................... 396
9 -79.200[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  29  1......................................................................................................................................................................................................................................................................................................MASAAVASMVLDPKAS-----PALMDLSTAD-EEDLYGRLKSLERQLEFTDIQEEYVKDEQKNLKRELLRAQEEQFMEMVDQNNGIVGSTTGSNYYVRILSTINRELLKPSAS------------------------------------------------------VALHRHSNALVDVLPPEADSSISEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATARFDAQTGADQRILMELLNQMDGFDQTVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLVFQVCTSKMNLSDEVDLEDYV--SRPDKISAAEIAAICQEAGMHAVRK-------------------NRYVILPKDFEKGYRANVKKPDTD..................... 403
10 -77.800[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  27  1........................................................................................................................................................................................................................................................MGQNQSAQGGAGEKKDDK-------DKKKKYEPPIPTRVGKKKRRAAMKLPQVTPHTRCR----------LKLLKLERIKDYLMMEDEFIRNQERLKPQEEERSKVDDLRGTPMSVG---NLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNH-------------------------------------------------KVHAVVGVLSDDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRMTLAEDVNLSELI--MAKDDLSGADIKAICTEAGLMALRE-------------------RRMKVTNEDFKKSKESVLYR......................... 428
11 -76.600[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  28  4........................................................................................................................................................................................................................................................................................................................LQFSNMVEPTGPAIVEDSYRRKLAECRDIEQKLKDLRKKESEMTKQFDK-----SENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNGPRYVVGCRRSINKEELK-----------------------------------QGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADRRTLMELLNQLDGFDSLGKVKVIMATNRPDTLDPALLRPGRLDRKIEIGLPNEQSRLEILKIHSNKITKHGEIDFEAVV--KLSDGFSAADLRNVCTEAGMFAIRA-------------------EREFVIDEDFMKAVRKVGDAKRLETKLDYKPV............. 406
12 -73.800[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  26  2...................................................................................................................................................................................................................................................................................................................................PDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQI------HIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLA--RLCPNSTGAEIRSVCTEAGMFAIRA-------------------RRKIATEKDFLEAVNKVIKSYA....................... 421
13 -72.500[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  28  22......................................................................................................................................................................................................................................................................................................................................TEDITRATRLLDNEIRI--LKEDAQRTNLECDSYKEKIKENQEKIKLNKQLP-YLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLK-------------PGDLVGVNKDSYLILDTLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTKRFDSEVSGDQRTMLELLNQLDGFSSDERIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARARILQIHSRKMNVHPDVNFEELA--RSTDDFNGAQLKAVCVEAGMLALRR-------------------DATEVNHEDFNEGIIQVQAKKKAS..................... 419
14 -60.700[O] KOG0739 AAA+-type ATPase  ali follow..  27  68..................................................................................................................EKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGK-RTPWRGILLFGPPGTGKSYLAKAVATEANSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEAARRIKTEFLVQMQGVG---NNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPLPEEAARAQMFRLHLGSTPHNTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMIDDLLTPCSPGDPG---------AMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKVKK................................................................................................................................................................................................................................................................................................... 428
15 -59.000[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  30  88............................................................................................................................................................ESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEY-LRNPEKF---GKWAPKNVLFYGPPGTGKTMMAKALSNEAKTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPCIVFLDEFDAIALDRGQEIRGDVSEIVNALLTELDGTNS----NEGICTIAATNRVELLDASI--RSRFEEEIEFRLPSYEERLEILRRNLEEFPVPVKARLELVAAASEGFSGRDLVEKVIKASLHKAIA............................................................................................................................................................................................................................................................................................................................................................................................ 321
16 -51.500[O] KOG0743 AAA+-type ATPase  ali follow..  15  207...........................................................................................................................................................................TFDTLAMDPNAKKKIIDDLERFLKRKEFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSI------YDNGELKRVLLSTTNR--SILVIEDIDCNAEVRDREAENQEDETLSGILNFIDGLWSSFGDER--IIVFTTNHKERLDPALLRPGRMDVHINMSYCTGLGFRTLVSNYLGLDGLNHPL-CEEIEALVDSVTPAELAEELTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLSKNLTMVIDEIIGFKRNQVFDAAHPSTFETLAMDPGAKKKIIDDMERFLKRREFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSI------YENAQLKSILLSTTNR--SILVIEDIDCSSAEVVDREADEYQETLSGLLNFVDGLWSSDERIIVFTTNHKERLDPALLRPGRMDMHINMSYCTGLGFRTLVSNYLGLGGLNHPL-CEEIEALIDSTEVTPAELAEELTDVVLRGVVSFVENRKVEISKTKELEGSTCRKLDGDDKHNVSSTNDLKKTKKKKKGGKGKAKGN.......... 996
17 -50.800[O] COG0465 ATP-dependent Zn proteases  ali follow..  26  136.............................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEEVSELVDY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGGHDEREQTLNQMLVEMDGFEG----NEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGLPDVRGREQILKVHMRRVPLDTDIDASVIARGTPGFSGADLANLVNEAALFAARG----------------------------------------------------------NKRVVSMVEFEKAKDKIMMGAERRSMVMTEATAYHEAG---------HAIIGRLVPEHDPVHKVTIIPALGVTFFLPEGDAISASRQKLESQISTLYGGRLAEEIIEKVSTGASNDIKVATSIARNMVTQWGFSEKLGPLLYAEEEGSDETARIIDQEVKLLVERNYQRARKLLLENMDVLHSMKDALMKYETIDAP............................................................................................................................. 587
18 -50.300[O] KOG0740 AAA+-type ATPase  ali follow..  25  317.........................................................................................SGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGL--GPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDR--ILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARKQIVINLMSKEQCLSEEEIEQIVQQSDAFSGADMTQLCRGASLGPIRSLQTA----------------------------------------------DIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYEN................................................................................................................................................................................................................................................................................................... 665
19 -45.100[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  24  303............................................................................................................................................................KATITRADKHSKNKIYFKDVAGCDEAKQEIMEFVHF-LKNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPSRVRHLFQEARQAAPSIIFIDEIDAIGRARGRGGNDERESTLNQLLVEMDGFGT----TAGVVVLAGTNRPDILDKALLRPGRFDRQITIDKPDIKGRDQIFKIYLKKIKLDHEYYSQRLAALTPGFAGADIANVCNEAALIAARH----------------------------------------------------------EGATVTMAHFESAIDRVIGGLEKKNRVISKLVAYHESG---------HAVVGWFLEHAEPLLKVTIVPAALGFAQYVPNENLLMTKEQLFDMTCMTLGGRAAEQVL---IGKISTGAQNDLEKVTKMTYAQVFSDKVGLLSFPPRDDSNKTGAIIDEEVRDWVAKAYERTVELVEEHKVKVAEIAELLLEKEVLHQD............................................................................................................................. 749
20 -44.800[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  23  266.............................................................................................................................................................GLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRISPMHPYSRQTINQLLAEMDGFKP----NEGVIIIGATNFPEALDNALIRPGRFDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVD----------------------------------------------------------GKEMVTMKELEFSKDKILMGPERRSVEIDNKTAYHESG---------HAIIAYYTKDAMPINKATIMPTLGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIDHITTGASSDFDNATKIAKRMVTKFGMSEKLGVMTSDTGKLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALLTYETLDAK............................................................................................................................. 702
21 -29.900[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  12  50.....................................................................................................................................................................PDPHTFPLVRLAGVGRQTELLVRNTEQFIVG---------RPANNVLMSGARGTGKSSLVKALLHEYADKGLRL---EVDKSDLIGLPYLLTLL---KECPEKFIVFCDDLSALKTALDGGLSQRCANVLVYATSNRRHLEYFDENAGTTGMRGEIHQKEAVEEKISLSDRFGLWLSFYPFDQNDYLAAVQNWLEDFGVPYDETAQMAALQRGSRSGRSAWQFACDWAGRLPKQR........................................................................................................................................................................................................................................................................................................................................................................................... 285
22 -27.600[K] COG1224 DNA helicase TIP49, TBP-interacting protein  ali follow..  12  1.............................................................................................................................................MAGEIREITQTFERISAHSHIRGLGLDENLRAKDVADGLVGQKRAREAAGVIVR----LIKSGKMAGRGILMAGPPGTGKTAIAVAISKELGIPFVQVSASEFYSAEMKKTEALIQAMRKAVRIRETRTVLEGEVVGLDYNMVPNPYNPTQKIPESATLTLATKDEKRTSVGGRLAMQFFTQGIEVGDVIVI--DKETGRIGKLGRSEKAKKKYDLGDDEVVPVPSGKVEKEKEFTYVVTLHDLDEANARRTSIFSLFSPPSREIDNEVREAVDEQVKRVEEGRAELVPGVLFIDETHLMDIELFAFMNRAMESEMAPIIILASNRGFSRIRGTDIVAPHGIPL-------------DLLDRLLIITTEPYSREEIKTIIEIRAAESGI----SNEAMEKLTDGEKTSLRYAVQLLAPAYEFAKMRNSGKERAASIFADVSQSSAYL............................................................................................................................................................................................... 439
23 -21.100[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  17  180...............................................................................................................................................................................IGRDEEIRRAIQVLQRRTKNNP--------------VLIGEPGVGKTAIVEGLAQRIVNGEVGLKNKRVLSKYRGEFEERLKAVLNELSKEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLAR-----------GELHCVGATTLDEY-DAALER--RF-QKVFVGEPTVEDTIAILRGLKERYEIHHHVQITDPAIVAEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAELEDQLAQAESAEGKEMTLLRYRVTDEEIAEVLSRAT-EGEKEKLLRMEEELHKRVIGQHEAIEAVSNAIRR--------SRAGLSDPNSFLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFMEKYVGYEEG---GYLTEAVRRRPSVILLDEVEKAHHD-----------VFNILLQVLDD--DFRNTVVIMTSN-KELVMSVVGQ-NRIDETVVFHPLGKENIREIATIQLARLI--TDACLDFIGEVGYDPVYGARPLKRAIQQEIENPLAQQILSGKLLPNQLVTIDYVDGKVIANQ...................................... 855
24 -18.900[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  25  1.................................................................................................................................................MIEADRLISAAVINDEESIDRAIRPKLLTEYVGQPHVREQMEIFIQAAKQRGDALDH--------VLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVL------EKAGDLAAMLTNLEPHD--VLFIDEIHRLSPVVEEI-PAMEDYQLDIMIGEGPAARSIKLDLPPFTLIGATTRAGSLTSPLR--DRFGIVQRLEFYQVADLEHIVSRSAKCLGLELTPEAHQLARRSRGTPRITNRLL....................................................................................................................................................................................................................................................................................................................................................................................................... 227
25 -17.700[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  19  184...............................................................................................................................................................................IGREDEIRRTIRVLSRRTKNNP--------------VLIGEPGVGKTSIAEGLARRIIDDDVNLSNCKLLSKFRGEFEERIKSVLKEVEESEPIILFVDEMHLLMGAGSGGEGGMAANLLKPMLAR-----------GKLHCIGATTLAEY-DAAFER--RF-QIILVKEPSIEDTISILRGLKEKYEVHHGVTLVTAAHLASRYLAIDLVDEAAAAVRVTRESQPEVLDNLERKLRQLRVEIRALEREKDEASKERLKAARKEAEQVEEETRPIREKYELEKSRGSELQDAKRRLDELKAKAEDEIVARWTGIPVTRLKGQNEAVTAVANAIRAGLSDPN-------QPIASFLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYMEKYVGHEAG---GQLTEQLRRRPSVILFDEIEKAAPE-----------VLTVLLQVLDD--DAKNAVIIMTSN--EMVMNSIRG-NRISSIVIFNRLRRVDIRNIVENRILEVQ--SDEAKDLLGSAGYSPAYGARPLNRVIQNQVLNPMAVLILNGQLRDKETAHVVVQNGKIFVKPNH.................................... 880
26 -17.100[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  12  293......QFNQLFGQQINLLLHPSQNVIDNPVYLCDLVATLVQSAETKDLQEMMDEID-----------VSKRLKIALLLIQKEKAVAKLKYDINKDVEKKVQDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKSVTRNYLEWLTSVPWEGHYGMKDVKERIMEFIAVNLLRKSIGGKI-------LCFHGPPGVGKTSIAKSIATALNREYFSVGGAEI-RTYVGAMPGKMIQCMKKVKTENP-LVLIDEVDKIG--GAGFHGDPASALLELLDPENDHFLDVPVDLSRVLFICTANEISKIPGPLR--DRME-MIDVSGYLAEEKVEIAHQHLIPQLRKDTSLATEQLKIEDSALEELIKHYCRESGVRNLQQHIERIFRKA-----ALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFVGRPKFTSDRMYEVTPPGVAWTAMGG----------YIETVLKRPVDLTN--------------DKDGSIETTGNLGDVMK---------ESVRTALTVAKGILAREQPDNKFFDKAHIHIHVPEGATPKDGPSAG----TLVSSLLSLALDRPVVQDMAMTGEISLTGKVLPAARRVG---KRVFLPNENRRDFDDLPEFMKSELDIRFVSHYDEL............................................................................................ 965
27 -16.900[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  12  149............................................................................................................................................................................................................LVQKRPILLAGPEGIGKKFLITQIAAKLGQQIIRIH-KMLIGTYTSPKPGEFEGVLTQAVITGKWIL-FTNIE------------APSEVLSVLLPLLEKRQLVIPSRGETIYAKGSFQ--TSSMKTKILGQRLWQILDLTYQPDECVEVVSTLYPVLSIICPTLYSVYKDIFDLFSQRSFLATSKIYRRLCLRDFYKFIKRVAFLYHKFMIPSDHVVISQELQDAVFKEAIDMFGAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIGRCSLKKLSTIRSCSTNSYAFTSSSLGLLEQLAAG-VQTNEPLLLVGETGTGKTTTIQLLAGLLGQKVTVINSSDMLGGYKPINASRFIDIFEQTFSSKKNAKFISMASTSARRFRKTCLKIWKEACKLSKTVLDGQQPLPNPQKRQK---------------RLSNQVELRNQWAKFEKEVEDFEKVLTGGSNGFMFGALVKAVRSGHWVLLDEINLASLETLEPIGQLLSSYESGILLSERGDIT----PITPHKNFRLFGCMNPSTD----VGKRELEPSFRS....... 709
28 -14.800[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  13  124...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STILCREDEQIRIFEFVKGCIDQ---------QKAGSLYICGCPGTGKSLSMEKVVQQVPVDTLSVNCTSLSKTTDSSPLQHLQNLFSQSSSSRMMLIIADEMDYLITKDRG--------VLYDLFMLTT--LPFSRCILIGVANAADRFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRVLS-YVAFQPKALELCARKVAAASGDMRCVCRSALEILEIETRGSTGPESQGPTPDDS-----VVRMDHMAAALSKTFKSPVVETIQSLPQHQQIIICAA..... 418
29 -14.500[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  13  191....................................................................VRERYFAFFEILMKQKENINFQMEMAKKVTDKISKSNREAMLREQLKMIQEELNGGD-DAASGEGGYRERIEKSTMPEEVKKKALSELKKSVIRNYLDLMLDLPWSNHNGLEKVKERIIQHLAVMKLKKEKQGSI-------LLLTGPPGTGKTSLGKSIADALGREYISLGGAEI-RTYIGALPGRIIQGMRKAGTKNP-VFILDEVDKLSTSYAGDPASALLEVLDQNNTFSDHYLEVPYDLSEVFFIATANSLASIPWPLL--DRME-TIEISGYTKNEKLAIAKDHLLPCILEEHGLDADKLKIEDEALKGIIDKYTREAGVRGLKKQLART---------------------------------------ARFVSEKIVSGKTDLPYVVRADMLKEVLGKEIIRQEEARKENVPGVAWTPVGG--------------------LFIEGTFMPGNGKLT-----TGQ--LGDVMKESAQISLSLVRS---------LASTENSFNFTASD------VHIHVPSGATPKDGPSAG----TLFTALTSLITGKAVDPKLAMTGEITLSGAVLPAAHRAG---KKVILPKENERDLEDVPEEVRNELKFVPVETIEEV............................................................................................ 768
30 -13.600[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  12  14.....................................................................................................................................................................VGLPPYTYVKPKHFGEVRADIS------------------QVGKHLLIEGPSGIGKTCVVFKVFEELQWSQRDFTYVGCRDQNAEQIIDDFLKNAAAGNALSPCVLVIDDFHLL--------SQAKRMEIGSTLKRLSDRAFEQAEPAKVILIGIPTAGVSLAYDLG--PRLGS-YALTRASDVEIDKLISEGEQALAVLFE-DRDVLLAESAGNFWL-AQYVCNKVCAIEVYETQDDAKILTFDILGIRGRLMAELTQRYLPIARTFAKGKRWRPGGNKPYLEILLALCKIQDSVVTFDQLLQLVSERRRPGLKAVRTRSEVIFDPDHGTDLRKQIAFEADSGFSIEDPLFRYFL-----------------TNLDSTLLFRDLGIEENTVERGDIGFSFAGEARRLVELVNAEMKAED---TFYDF---------DQQAILLAMDLQDILGKVYGESCRYYLVFLDKNYREKV---------RFEKDV---MTNGKRIDHIVPIVI------DDEGASGTVGISNTIGRIDLKDVWAQIQKAGKISTDDVNTIKNR........................................................ 508
31 -13.400[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  17  40...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DLLLHRNEQINSLATILVSALRG---------ETPSNVLIYGKTGTGKTAVTRYVGKELECSVVYINCEVIDTQYTGWPTDQVFMKFKEAARDQVIIIILDEIDKLIKKGDD--------VLYNLSRINTDLRK-AKVSMIGVSNDTEFLDPRVKSS---EEELIFPPYDAEQISDILKQRAKMAYNDGVLGEMVIPLCAAFAAQEHGDARDLLRVSGEIA-------------------ERENQPQVLEEHVRRAQEKIEIDRVVEVVRTLPTQSKLVLYSI..... 317
32 -12.700[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  13  355...........................................................................................................................................................................................ENFTISAKGNDLFVNANLLIAHGYGLVGPNGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQEELNDTFAEL-KAIGAYSAEARARRILAGLGFSKEMQDRPTNKFSGGWRMRVSLARALYLEPTLLMLDEPTNHLDLNAVIWLDNYLQGWKKIVSHDLDNVCNEIIHLDQKKLQYYKGNYSMFKKMYVQKRREMIKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYI---KFRFPEPSQLQPPILGVHNVTFAFPSQKPLFIKVDFGIDLTVAIVGPNGVGKSTFLKLLLGELEPQEGEQRKNEYLQRLFNLPHEKARKALAELCLSAPDVLILDELD-----------------IESIDALAEAINEYEGGVIIVSHDE.............................................................................................................................................. 848
33 -12.700[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  14  338.....................................................................................................................................................KKILETVARMDDSNKKESQPSQIWKDICGNKGVVQKLQKWLQ--KSNFNKPGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASD------TRSKRLLDEQLFGVMAKSRLVLIMDEIDGMS----SGDRGGVGQLNMII----------KKSMIPIICI--CN--DRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMSIAYREGLKLSPQVDQLVQGTQS----DMRQIINLLSTYKLSCSEMTPQNSQAVIKNSEKHIVMKPWDICSRYLHGGMFHPSS--KSTINDKLELYFNDHEFSYLMVQENYLNTTPDRIRQEPPK------MSHLKHLELISSAANSFSDLVDSMIHGPQQHW---------SLMPTHALMSCVRPASFVAGSGSR---QIRFTNWLGNNSKTNKREIQVHMRLKVSANKLDLRQHYIPILYESLPVKLSTGHSDVVPEIIELMDEYY........................................................................................................................................................... 803
34 -12.700[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  23  58......................................................................................................................PKALAPAMGDDSSKRPNPKTQIHVAADDSNKRHKLSSSSHRQHQPLSERMRPRTLDDVVGQDHLLSPLRSAVE--------------NRLPSIVFWGPPGTGKTSIAKSLINSSKYRFVSLSAVT-------SGVKDVRDAVESAKRLNRTVLFMDEVHRFNKSQQ-----------DTFLPVIE--------DGSILFIGATNPSFHLITPLLS-----RVLTLNPLKPNHVETLLRRAVDDSERGDDSVIEFLANNCDGDARVALNAL....................................................................................................................................................................................................................................................................................................................................................................................................... 306
35 -12.400[R] KOG0927 Predicted transporter (ABC superfamily)  ali follow..  12  2.................................................................................................................................SSAAKKREAQKKKDARNKKIQQIPSTKKANGVPERELTEEEKLCAKLEEEARISAEARANFSITFFGSELLQDTMLELNCGYGLIGLNGCGKSSLLAVLGGREVPVPPHIDIFHLTREIPASSKSALQCVMEVDEERI-------KLEKLAEELAMSEEDDAQEQLIDIYERLDDMSADLAEVKAARILHGDKAMQQKQAKDFSGGWRMRIALARALFVKPHLLLLDEPTNHLDLDA---CVWLEEELKTYKRILVLISHSQDFLNGVCTNIIHLTGKRLKYYTGNYEAFVRTRMELLENQMKQYNWEQDQISHMKNYIARFGHGSAKLARQAQSKEKTLAKMVAQGLTEKVSDDKVLNFYFPSCGKVPPPVIMVQNVFRYNDETPWIYKNLEFGIDLDLALVGPNGAGKSTLLKLLYGDLRYGLTGRQQVCPIRQLSD---QRCRVVFAWLAWQVPHLLLLDELD-----------------METIDALADAINDFDGGMVLVSHDF.............................................................................................................................................. 563
36 -12.300[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  10  55..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FPGVVGYDDTVIPQLVNA--------------LLARQNFILLGLRGQAKSRILRAITELLDPEVPVIDGADLIGDVDPIKAARLGTSLGDTRSMHFGIFAVNELADLSP-----------KVQVALFNILQPIRLELDVMLVFSANPEDKIVTPLK--DRIGSEIRTHYPDVQLGMDITAQEAEGVVVPPFI-IEDIAFQAREDGRIDSLMELACANAERRSLVSGDAPVVRVTDVYAGLPAITGKMELEYEGELKGADNVAKDL........................ 379
37 -12.300[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  18  77...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QYVIGQERAKKVLAVAVYNHYKRLNQRDKKD-LGKSNILMIGPTGSGKTLLAETLARLLNVPFTIADATTLTAGYVGEDENIIQKLLQKCEKAQMGIVYIDEIDKISRKSDNPSITRDEGVQQALLKLIEGVDTRNILFICGGAEPEDLVKFGLIPEGRLPVIATLDELDEAALMQILTEPKNALTKQYA---KLFEMEGVDLEFRPDALKAVARKAGARGLRSILEGILLDTMYEIPSQQDVSKVVIDESVIDGSSQPL............................ 410
38 -12.200[L] COG0470 ATPase involved in DNA replication  ali follow..  20  23...........................................................................................................................................................................TLDEVYGQNEVITTVRKFVD--------------GKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLEL-NASDDRGIDVVRNQIKDFASTRQ-LIILDEADAMTNA-----------AQNALRRVIE------RYTKNTRFCVLANYAHKLTPALL--SRCTRFRFQPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRVLNVL....................................................................................................................................................................................................................................................................................................................................................................................................... 212
39 -12.200[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  17  394...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSLPCRSKEMEEITAFIKGSISDDQ-------CLGRCMYIHGVPGTGKTISVLSVMKNLPYCFVEINGSVIYEGLSGHRVGSLNERFAEKENEKPCILLIDELDVLVTRNQS--------VLYNILDWPT--KPNSKLVVLGIANTMDLPEKLLPRSSRMGQRLCFGPYNHRQLQEIISTRLEGINAFEKTAIEFASRVAAISG----DAREICRRAAEVA-----------DYRLKKSNISAKSQLVIMADVEVAIQEMFQAPHIQVMKSVSKLSRIFLTAM..... 681
40 -12.100[L] COG1484 DNA replication protein  ali follow..  15  88................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TEGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELYVPVIYFPFVEGFTDLKNALLEAKLNRMKQAD-----VLFIDDL-----KPVNGKPRATDWQLEQMYSVLNYRYLNHKPILLSSELTIEGLEALGTKIYEMCSDYLVIIKGAAYELN................................................................................................................ 259
41 -12.100[R] COG2401 ABC-type ATPase fused to a predicted acetyltransferase domain  ali follow..  11  105.....................................................................................................................................................................................AREAVYEKDFERIAELEQYH---ASQKSKVALWKCYDCGNLIEANT-CGSRNVHIVEIKGSTPASRF------LIFELVERQPFEPEVVVRVDPPVPLMHRK--ENVFSPEKELSELFRKLRSRFSLKVARHRLWEEASEEAMKKCNSAASRIARVYRADGLGILAVRTAVEWIEERRVPEMRMRKHLVETIAQM------ARFNPFFEKAGFYYLWDTASG-------------------KPVLYKPLSEEAERYIRKFLEEDEVARGHGGKLCVSRYGSVKPLEKLKFRNVSKLFASTLDLEKVSDEVRTVLESFGVRQRVVER--------YVLRDVNLEIKPGVAVVGASGSGKTTFLRLIVGEALLNRAGISDAVLYRARFNELSQKERFKLAACLAKKPSLMLVDE----------FAAHLDEMTAVRVARKISELAREAKITLIAVTHRKEVINALYVGYGGVTES............................................................................................................................. 619
42 -12.100[O] COG4930 Predicted ATP-dependent Lon-type protease  ali follow..  10  49.........ANVPVYVLEYLLGMYCASDDDQIVEQGLQNVKRILADNYVRPDEAEKVKSLRERGSYKIIDKVSVKLNQKKDVYEAQLSNLGIKDALVPPQMVKDNEKLLTGGIWCMITVNYFFE------EGQKTSPFSLMTLKPIQMPNMDMEEVFTARTHFNRDQWIDVLLRSVGEPANIEQRTKWHLITRM----------VENNYNVCELGPRGTGKSHVYKECSPNSL---LVSGGQTTVANLFYNMASRQIGLVGM-------VVAFDEVAGITFKDKDGASGSFSRGRDSIEGKASMVFVGNINQSVETLVKTSHLLAPFPAAMIDTAFFDR-FHAYIPGWEIPKMRPEFFTNRYGLITDYLAEYMREMRKRSFSDAIDKFYKLGNNLNQRDVIAVRRTVSGLLKLLHPNGSYSKEDVRVCLTYAMEARRRVKEQLKKLGGLEFFDVNFSYIDNETLEEFFVSVPEQGGSELIPAGMPKPGVTQAESGMTGLYRFETQMT---------------------------AGNGK---------------HSVSGLGSSTSAKEAIRVGFDYFKGNLSRVSATAKFSEHLHVVELHNTGPSTATSLAALIALCSVLLAKPVQEQMVVLGSMTLGGVINPLAFDSG---KKVLLPMSSAVDIPTVPAELFTKFQVSFYSEPVDAVYKA........................................................................................ 690
43 -11.900[R] COG1855 ATPase (PilT family)  ali follow..  12  5............................................................................................................................................................................................................................RAITHASTGGWKEMKYVVDTSVVI-----GRVTEMLESGEIKGTIIVPEAV-MAELEAQANFGKMTGFQGLSEI--EKLTKL-------AKDKGFEVIFAGERPKLEHIRLAKGGEIDNLIREVAAEFDAVLVTSDRVQHLVARAKGIETIYVRPRVVRPENTRIMSFFTPDTASV------REGVPPYAKRGRIGDLKLVKLDDRPMSYEELNEIANEILEAARQDEDSSIEIERRGATVVQLRELRIAIRPFADRMEITAVRPIAQVSIDEYGVSEELKRRIVE------------------RQRGILISGPPGAGKSTFAASVANFLLENGYIVKTME-EITQYAPLEGDMSLTSDILLLVRPDYTIYDEL------RRTSDFQVFADM------------RLAGVGMIGVTHATRAVDAIQRMIGRVELGMIPQVVDTAGRIVKVYELSFTVKVPTGMTEADLARPVIEEIYTYGEQVVVMPIETDENLKAALEEKISKYVDDFEVEMVGRKAVIKVPEKHIPTLIGRKGRRIKNIEDEFKISIDVIPKEV.... 531
44 -11.900[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  15  156................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FFLYGGTGLGKTHLLHAIGNGINARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLD-ALLVDDIQFFAEKEKTQE---------EFFHIFNSLFETGRQIILTSDRYPKEIEKIEER-SRFG--TAIEPPDLETRVAILLKKAEEHNMNLPEEVAFFIAQRLRTNV--RELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEY--RIKVSDLKSKSRARS........... 390
45 -11.800[T] COG0467 RecA-superfamily ATPases implicated in signal transduction  ali follow..  9  1..................................................................................................................................................................................MIDQETDGIEKLETGIPGFDFLSDGGLPLGRATLIAGTAGSAKTIFASQFLVEGGENGVFVTFEEPPKALRKNMGALIARIEHAVRKYKASRISLDSLGAIFSHLSDSAQ---RSDLFRLASAL-----RELGVTAIMTAERVEEYGEISRYGVEEFVADNVVIVRNVLADEKRRRTIEILKYRGTDHQKGEFPFTIINKKGIVIIPLSAIELEQKSSDIRITSG------------------------------------------------------------------------------------------SEELDRMCG-------------------GFFRDSIILVSGATGTGKTLMVTEFMDG-GERCLVFAFEESREQLIRNAENHLIMMKDIIQEFKPNRVAVDSLSAL---ERVSTLKSFREFIIGLTSFIKQQEIG--GLFTSTTPNLLGGASITDAHISTITDSIILLRYVEMYGEMRRGI........................................................................................................... 445
46 -11.700[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  11  37......................................................................................................................ATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWHELAVHKKKIEEVETWLKAQVLERQPKQGGSI-----LLITGPPGCGKTTTLKILSKEHGIQVQEWINPV-FQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKGDDLRTDKKII--LVEDLPNQFYRDSHT-PLIFIISDSLSGDNNQRLLFPKEI-SNISFNPVAPTIMMKFLNRIVTIEANKNGGKLELLCQGCSG----DIRSAINSLQFSSSKGSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILYCKRASLTELDSPRLPSHLSEYERDTLLVEPEEVVEMSHMPGDLFFMEIDDIVRASEFLSDILSGDWNTRSLLREYSTSIARGVMH------SNKARGYAHCQGGGSSFRPLHKPQWFLKKYRENCLAAKALFPDFC-LPALCLQTQLLPYLALLTIPMRNQAQISFIQDIGRLP............................................................................................................................................................... 588
47 -11.700[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  17  46...........................................................................................................................................................................KLNEIVGNEDTVSRLEVFAR--------------GNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLEL-----ASNDRGIDVVRNKIKMFAQQIIILDEADSMTDG-----------AQQALRRTME------IYSKTTRFALACNASDKIIEPIQ--SRCAVLRYTKLTDAQILTRLMNVIEKERVPYTDDGLEAIIFTAQGDMRQALNNL....................................................................................................................................................................................................................................................................................................................................................................................................... 236
48 -11.700[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  21  25...........................................................................................................................................................................TVEQYIGQQHILGPLRRALE--------------GHIHSMILWGPPGTGKTTLAEVAANYANAEVERVSA-------VTSGVKEIRAAIEKARENK-TILFVDEVHRFNKSQQ-----------DAFLPHIE--------DGTVTFIGATNPSFELNNALLSRARVYKLTSLNQQEILQALHQAIADTERGLGKVAAVFADLAELVNGDARMSLNYL....................................................................................................................................................................................................................................................................................................................................................................................................... 216
49 -11.700[S] COG5324 Uncharacterized conserved protein  ali follow..  9  66................................................................................................................................................................................................................RGLFISDDTTNPV-IVARGY------KFFNVEVNFTKWNWIEENCTGPYDVTIKANGCIIFISGLEDGTLVVCSKHRNHAEAGEKQLLRQLAAMN--INRSDFARMLYTHNVTAVAEYCDDS-------FEEHILEYPLEKAGLYLHGVNVNKAETWDMKDVSQMASK--GFRCVQCITSNTLEDLKKFLDNCSATGSFEGQEIEKPFFFKYKFEEPYLMYRQWREVTKDYISNKSRVFKFRKHKFITNKYLDFAIPILESSPKICENYLKGFGVIELRNKFLQSYGMSGLEILNHEKVAELELKNAIDYDKVDERTKFLIFPISVIGCGKTTTSQTLVNLFPDSWGHIQNDDITGK---DKSQLMKKSLELLSKKEIKCVIVDRNNHQFRERKQLFEWLNEKVIGVSFAPYDKLSEIRDITLQRVIKRGNN-HQSIKWDELFDLMIELDFGQADSSLTNAKQILNEIHKAYPILVPEIPKDDEIETAF-----RRSLDYKPTVRKIVGKGNNNQQKTPKLIKPTYISAKIENYDEIIELVKRCIASDAELTEKFKHLLAS.......... 665
50 -11.600[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  18  49...........................................................................................................................................................................SLDDVAAHRDIIDTIDRLTN--------------NKLPHLLLYGPPGTGKTSTILAVARKLRNMILELNASD--DRGIDVVRQQIQDFASTQSFSLG-LVLLDEADAMTKD-----------AQFALRRVIE------KYTKSTRFALIGNHVNKIIPALQ--SRCTRFRFAPLDGVHMSQRLKHVIEAERLVVSDCGLAALVRLSNGDMRKALNIL....................................................................................................................................................................................................................................................................................................................................................................................................... 240
51 -11.500[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  10  48............................................................................................................................................................................................................IAEIPCLVLLGEPGVGKTHELEKLQRFTEET--ICEYSKVLGLNLRTFTNLKEDLFRDKEGHYHLHLFLDSLDEGLLNVKSLAIGLVDEFKKPK-IDVINAVEAEGFSSDDFLKAINQR---IVPLAIKPISLGFLLNTPPE--QKRYESYLEGCKCLCEEVSKC-RHALKETGNLDIDQRLIVAARIAAVTIFANRFAVWIDVEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLDTG--FSSRGLHRMGWAHQTYAEFFAAWYLTQRNIDLSKIKTLLYSSADSTPKLIPQLHETAVLASMRDNVFQEIIKTDPDVLLQTDIP---RATIVANLLMQYERNYAKLKHSGLAEQLKSSKKEDTRRIAIDIAIECNLSELQGDLAKLT--LCPSQPISIRVNAARAISSIGDQSTRLKLKSLALNVLPEDEQDELKA-----YALKALWPRQLTAEELFQALTPSKRINLLGMHRYFLESELVPQLDSEDLVIALD......................................................................... 613
52 -11.500[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  14  169......................................................................................................................................................ENQAKQTQLRLEELNQEAWSRDSVEIIGNSGPMLAMKADIDV------------APSQFNILIHGETGVGKELVARTISNRKRQPLVYVN-SELFGHVKGAFTGADRARMGKFALADGGTLFLDEIGELPL-------SAQSKILRAL-HEIQPVGQDRVQTVDVRILAATNR-----KKEVEAGRFRADLYIYVPPLRERKGLAGYFVEQARRKLGITQLKLHGDV-PWPGRELEHVINRAALKAKARQRGR........................................................................................................................................................................................................................................................................................................................................................................................ 432
53 -11.400[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  14  169..............................................................................................................................................................SRFAEERQQTLDFLKSGIATRNPHFNRMIEQI----------EKVAIKSRAPILLNGPTGAGKSFLARRIRHQFSGAFVEVN-STLFGHVKGAFTGARESREGLLRSANGGMLFLDEIGELGA-------DEQAMLLKAI-KTFYPFGSDRQVSSDFQLIAGTVR-----RQLVAEGKFREDLYFTLPGLRQRQENLDYEVERHASLTGDSVRFNTEARRAWLARELSASVTRMATFATSGRITLDV...................................................................................................................................................................................................................................................................................................................................................................................... 435
54 -11.400[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  16  4................................................................................................................................................................................................................PNILLTGTPGVGKTTLGKELASKSGLKYINAREEQLYDGYDEEYDCPILDEDRVVERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNIQCEIFQVEATASYKEEIVHQLPSNKPEELENNVDQ.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 158
55 -11.400[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  17  180..........................................................................................................................................................................VMLRSTIRMGQQLQNLSTQDLSKMKHVVEQARKLAMLSAPLLITGDTGTGKDLFAYACSPRSAKPYLALNCASI-SELFGHAPEGKKGFFEQANGGS---VLLDEIGEMSPR-------MQAKLLRFL-GTFRRVGEDHEIHVDVRVICATQKVELVQKGLFREDLYYRLLTLNLPPLRDCPQLTELFVARFADEQGVPRPKLSADLYGWPGRQLKNAIYRALTQLEGYELRPQD...................................................................................................................................................................................................................................................................................................................................................................................... 439
56 -11.300[R] COG0714 MoxR-like ATPases  ali follow..  16  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MREQISVLTQNLSQTIVGKDEAIRVALLSGGHALLEDVPGVGKTLLAKSLARSINGKFQRVQGTNIWNPSSREFEFLPGPAFAN-------ILLADEINRATPRTQAALLEV---MEEKQVTVDGETRLVPHPFFVIATQNPIEYQGTFPLPDRFALSLSLGYPSEAEELKMLQCISLEEVEALQKAVRQVKLTEDLQQYL-LRLVRASRTDEDVTLGVSPRGTTALQRATQAFAFLEERDYAIDDDVKFAPHVLAHRLIPASGKDPKAILQRLLDSVP.... 302
57 -11.000[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  11  75...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLLFGQHLVKDVVVNSIKSHWYNEN-------RKPLVLSFHGYTGSGKNYVAEIIANNT-VATNDFPDKNKLEEYQVELRNRILTTVQKCQR---SIFIFDEADKLPEQ-----------LLGAIKPFLDGVDFRRSIFILLSNKGGGEIARITKESGYPREQLRLEAFERELMNFSYNE-------KGGLQMSELISNHLIDHFV---FLPLQREHVRSCVGAYLRKRGRGDLVSNVD---------FVERVLNSLQYFPESSKAFSSSGCKRVDAKTDLEMA.... 341
58 -11.000[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  12  46................................................................................................................................................................................................................................EAYIVPETRLREHRQQSEDLIAI----ARSGLENLFRQVAGQNYVLLLSDREGVTVEFLGDPL--FGNSLRKAGLYLGSEWSEWRAGTCAVGACLETGEALTIHQTDHFDNTHTPLSCTAAPIYDIQGELSAV----------LDISLLSSPILKASQNLALHLVSATV-----RRIELANLMAQARNQWVLRFSRSPEFLDVDPEAAISIDGLGRIAGMTHAGAKILARSTGLDWRDPQQLIGEPVSRFSKVRAPLVSREQIPPALRRLGGDAPVIAALQAKAAK------------ARTRLPILIQGETGTGKEHLARAIGSGLEGPFVAINCAAI-GAFTGASAKGRKGLIEQADGGT---LFLDEI-----------GDMPLALQSRLLRVLAEGEVLPRIRIVSASHR--PLQTLVSQ-GAFREDLTLTLPALRDRPDVLEQLLKRHGDGELILSPAALSALKAHDWPGRELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGN--EASATLSLTLTACNWNIS-RRLGDRSTVHRQIKR....... 619
59 -11.000[A] KOG0063 RNAse L inhibitor, ABC superfamily  ali follow..  10  72..................................................................................................................................................................................IINLPKDLAKDTTHRYGANGFKLHRLPIPRPGLGLVGTNGIGKSTALKILAGKLKPNLTHFRGSELQSYFIRVVEENLKTAIKPQHVDYIKEVVRGNLGKMLEKLD------ERGLMEEICADM-ELNQVLEREARQVSGGELQRFAIAAVFVKKA----DIYMFDEPDVRQRLKAAQVIRSLLRHDSYV-----------VVEHDLSVLDYLSDFVCCLYGKPGAYGVVTLPFSVREGINVFLAGFIPTENLRFRD--------------------------------ESLTFRVSETTQENDGEVKSYARYKYPNMTKQLGDFKLEVMEGEFTDSQI-----------IVMLGENGTGKTTFIRMLAGAFPLQIEQLMDQVVKTLSGGEKQ---RVAITLCLGKPADIYLIDE----------PSAHLDSEQRITASKVIKRFILHAKKTAFIVEHDFIMATYLADR.................................................................................................................................... 535
60 -10.900[S] COG3854 Uncharacterized protein conserved in bacteria  ali follow..  11  120............................................................................................................................................................................................................VETGKSILMLGRPGVGKTTIARVLADELHKRVVIIDTSEIARMQVAHPELQHQVMIEAVENHMPEVIVIDEIGTVGTAHGNQIENLIKNPTLSDLV---------GGIQAVTLGDDEARRRGSQKTVLE----------APPTFEIAVEMLERQRWVVHESVADTVDTLLRGRQ--PSPQTRTVDEQGKVAITRQLSVVNGRGGQLATPEESFAP------ARPSNGWRASGQMLAIPSLPLERERISGQSEFDRLLDESFNYPEAIDFGSSARQPGPNGEDLPLHVYPYGVSRHQLEQVISVLTLPVVLTKDIDN------ADAILALRSHVKNHAKLRQMAKARHVPIHVIKSSTI-----PQITRGLRRLLNMEDPEVADDRELQLFLHNGSDDEMDALEEARLAVEQIV-----IPKGQPVELLPRSPQVRKMQHELVEHYRLKSHSFGEEPNR--RLRIY.............................................................................................................. 577
61 -10.900[R] COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase  ali follow..  12  54.........................................................................................................................................................................................................SFSIEPGKTLCVVGESGSGKSVTARSILQYITSGSIILNKADGSSVDLAKLDPRGRAI-RAVRGADIAMIFQEPMSSLSPVHLKMSKAQARAEAIELLRQIPNPEKALDRYAFQYSGGMRQRAMIAMALACKPQLLIADEPTTALDVTTQAEILDLISR---LQKAHGMAVL------FITHDMGVVAQIADDVLVMHHGVVKEYGTVEQIFHKPQ-----------------------------------------------DPYTRMLIGSVLKLEQKAEIRLARPPLDQTAAPILEVKDLS----MHFGEMKALDGVSIKLLPGLGIVGESGSGKTTMGRSIMRLYRADGSVVDLSKIEGKELKAARRELRMVFQDPFGSNPRMTVAQVIEPLLVNGIAKGKELEERVCSLMEQVFSGGQRQRIGIARAITLRPRII----------EATSALDVSVRFQVLDLLMKLQDELGLA----------------FISHDIGVIRYMCDRVGVMYRGKLVEVGEAEKVCNAP--------DHPYTQALLSAIPRPD....................... 566
62 -10.900[P] COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA  ali follow..  12  11...........................................................................................................................................................................................LQGTFRLSDTKTLQLPQLTLNAGWAFVGSNGSGKSALARALAGELPLL-RQSQFSHITRLSFEQLQKLVSDEWQRNNTDMLGPGEDDTGRTTAEIIQDEVKDAPR--CMQLAQQF-GITPLLDRRFKYLSTGETRKTLLCQALMSEP----DLLILDEPDVASRQQLAERLAS----QSGITLVLVLNRFD-----EIPEFVQFAGVLADCTLAETGAKEELLQQALVAQLAHSEQLEG-----------------------------------------VQLPEPDEPSARHALPANEPRIVLNNGVVSYNDRPILNNL------------SWQVNPGEHWQIVGPNGAGKSTLLSLITGDHPQGYIGYVSSSLHLDYWGQQR---LALIVRALVKHPTLLILDE----------PLQGLDPLNRQLIRRFVDVLISEGETQLLFVSHHAEDAPACITH.................................................................................................................................... 475
63 -10.800[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  15  214.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VLGDMLGQSPQMEQVRQTIL-------------ARSSAAVLIEGETGTGKELAAQAIQGKKSHPFVAVNCGAI-GAFTGSRRGGRAGLFEIAHGGT---LFLDEI-----------GEMPLPLQTRLLRVLEEKEVTRDVRVISATHC--NLEEDMRQ-GQFRRDLRLQLPPLRERVAFLKVSLAALSAPFSAALRQGLQASETPGNI-RELRNMMERLALFLSVEPTPDLTPQFLQLLLPELARESAKIPAPRLLTPQQALE........................... 502
64 -10.500[R] COG1245 Predicted ATPase, RNase L inhibitor (RLI) homolog  ali follow..  13  56..................................................................................................................................................................................INKCPFDAIMIIGLPEALQEPTHRYGPNPRIGTGILGPNGIGKSTSVQILSGTLVPNFGKGDWDTVLEHYAGTALHDYFKDVVDGKVKVPQYVDLIPKAFKGKTSELLEKTDERGFLDELIDRL-DLRGVVERKISELSGGELQRVAIAACAARDA----QFYFFDEIDIYQRINVARLVQE---ISKDRAVLVVEH--------DLAILDMLTDVIHIAY----------------------------------GEPAGFGVITLPKSVRVGINQYLKGYLPEENIRIRPEAIRFEVHPPREDAQFQSMVSFNS--------------FSKQYGDGFSLKATGGSLREGLGIVGPNGIGKSTFVKVLAGEIKLQLERIYESLLTELSGGELQ---RVAIAACLSQEADLYILDE----------PSAHLDVEQRSMVTKVINRFAENNQKTAMVVDHDIYMIDMLSQRLLVFEGKP............................................................................................................................ 527
65 -10.400[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  18  14...........................................................................................................................................................................KLQDVVGQEHITKTLQNALVQ-------------KFSHAYLFSGPRGTGKTSAAKIIAKAINVDVMEIDAAS------NNGVDEIRDIRDHVK--APSVYIIDEVHMLTTG-----------AFNALLKTLE------EPPSHAIFILATTEPHKIPLTII--SRCQRFDFKRISNDALVGRMKEILTHEGIEAEDEALVLVARAAEG---RDSLSLLDQA................................................................................................................................................................................................................................................................................................................................................................................................... 224
66 -10.200[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  12  554...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GHMDEQTKLYQWVRQTIVLGE---------GNSVIIVGPRGSGKSVLVDDILSRAKSYVVRLNGREISRQLFSDTLTKLLATLSHPTTSAAVIFVLEEFDLFVQHSRQ----------MLLYNLFDIAQSRKPILIIGLTTRYDCSESLEKRKSRFSMVIPMRPPSLSEFEQILKSVLY----DEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICA..... 859
67 -10.000[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  17  11..................................................................................................................................................................................................................VAILGGESSGKSTLVNKLANIFNTTSAWEYGRDYVFSHLGGDEIALQQYIDFAVKYANKVAFIDTTQAFCKKYEGREHPFVQALIDEYRFDLDGLRSLGSSVDRKEF-------NLLVEMLEENN---EFVRVEEEDYDSRFLRCVELVREM................................................................................................................................................................................................................................................................................................................................................................................................................................. 182
68 -9.920[F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)  ali follow..  17  3..................................................................................................................................................................................................................IAITGTPGVGKTTVAKLLAKKLNYEYVSLKGRRVNDEVEVEIDELAYFIERELKGKN-LVVVLRAHPKLIGERLRERGYDREKIGENVEAEL--LIEAIEEHENVIEVDTTNKPEDVVEEIVS.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 149
69 -9.910[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  15  266.........................................................................................................................................................................EPHIEQLVGECRVMRQLKRLISR------------APSPSSVMVVGESGTGKEVVARAISGRRNKPFIAIN-SELFGAFTGASANGKTGLIQAANTGT---LFLDEIGDMP--------MLQAKLLRAI-REILPIGASSPIQVDIRIISATNQAQFIAEGKFREDLFYRLIPITLPPLRERQELVHYFLHLHTRRLGSVYPGIAPDVHRWPGRELSNLMEYLVNVVPSGEV.......................................................................................................................................................................................................................................................................................................................................................................................... 509
70 -9.860[R] COG4172 ABC-type uncharacterized transport system, duplicated ATPase component  ali follow..  12  11.......................................................................................................................................................................................KDLRVRFRTLDGAVEAVKGINIHVNAGVAVVGESGSGKSQTMMAAMSLLASN-VDYRGRNLLTLSKSDLNAKISMIFQEPMTSDPLYSIGNQLIEPIRRHRGLNAAEAREEALKLLRLIPDPERRMKSYPHEMSGGQRQRVMIAMALANDPDILIADEPTTALDVTIQAQILMLLAE---LQRKLGMAIV------FITHDLGIVRRFADRVYVMRQGEVVEEGEAGAIFANPQ-----------------------------------------------HAYTKMLLAAEPTGSKAAPPANAPVVLE-GRHVEVTFKIGGGFLAGEPLMLRAVDDISIRLQRNIGIVGESGSGKSTLGRALLRLLPSD-IRFGDRDISTQAMRPLRRQMQLVFQDPFGSSPRMTVGQVIEGLLVHEPNLSGKQRDQRAVEALREFSGGQRQRIAIARAMILKPKMV-----------LDEPTSALDRSVQKQIVELLRK---LQADHELSYL--------FISHDLSVVRAMADYIIVMKQGKIVEEGPTEAIFSNP--------QHVYTQTLMAAAIDVT....................... 533
71 -9.830[T] COG2766 Putative Ser protein kinase  ali follow..  9  2...................................................................................................NIFDHYRQRYEAAKDEEFTLQDFLTICRQDRSAYANAAERLLMAIGEPNMVDTAQEPRLSRLFSNRVIARYPAFEEFYGMEDAIEQIVSYLKHAAQGLEEKKQI-------LYLLGPVGGGKSSLAERLKNDHPLCLFNPQ-AQILEKEYGIPRRYLGTALCRANQG---IMEFVEM-----------FKAPIKVLHPLLTATQEGNYNGTEGINGIILAHSNESEWFRNNKNNEAFLDRVYIVKVPRISEEIKIYEKLLNHSELAHAPCAPGTLETLSRFS---LSRLKEPENSSIYSKMRVYDGESLKDTDPKAKSYQEYRDY----------------------------AGVDEGMNGLSTRFAFKILSRVFNFDHAEVAANPVHL-----------FYVLEQQIEREQFPQEQ---------------------AERYLEFLKGYLIPKYAEFIGKEIQTAYLESYSEYGQNIFDR---------YVTYADFWIQDQEYRDP---------------------------DTGQLFDRESLNAELEKIEKPAGISNPKD--RNEIVNFVLRARANNSGRNPNWTSYEK---------LRTVIEKKMFSNTEELLPVISFNAKTSTDEQKKHDDFVDRMMEKGYTRKQVRLLCEW...................... 636
72 -9.810[F] COG2019 Archaeal adenylate kinase  ali follow..  12  3................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SVITGVAGVGKTTVLDIVARESGIPVVNYGNRDQIRKLSRETQVDLQKLAGEEIGKMENAIV--DTHMSIKTPFGYLPGLPEWVLRSI--------NASVFVIIEAD--PAIIKRRRDNDPTRARDDE-GVDSIREHQEMNRYFAAAYSIFSGATVKIVKNEEGKPEQAADEIVRVIK......................................................................... 181
73 -9.780[R] COG2842 Uncharacterized ATPase, putative transposase  ali follow..  10  94................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ATVYGMSGVGKTKAIQEFAKSHASEILYEIALELGISDAPRRKGTLSRLIARKIKGTEGLLIVDEADHL-----------PYEALEELRIMQE--EAGIGLVLVGNDKVYTRMKGGISPSSRVAKNTSIQKTKKADTQAVAQAWGLE---TDEEALKVMQSITETGGGLRI-LTQTYACRNGSK................................................................... 281
74 -9.770[G] COG3265 Gluconate kinase  ali follow..  16  2..............................................................................................................................................................................................................SGKCIIVMGVSGTGKSCVGQALALALGAKFID-AGQPLNDQ-CSALKKQYRDRLREGNEGIRFLWLTGDYDLVLHRMQQRAGHFMPE--SLLKSQFATLEAPGSDEPDVIPIDISSSIADVVEHCIA.............................................................................................................................................................................................................................................................................................................................................................................................................................................................. 164
75 -9.640[R] COG0488 ATPase components of ABC transporters with duplicated ATPase domains  ali follow..  13  22......................................................................................................................................................................................................ILKDISLSFFPGIGVLGLNGAGKSTLLRIMAGVDKEFEGEARQPGIKIGYLPQQQTVREAVEEAVSEVKNALTRLDEVYALYADPDADFDKLAAE-QANLEAIIQAHDGHNLDNQLERAADALRLPDWDAKEHLSGGERRRVALCRLLLEKPDMLLLDEPTNHLDAES---VAWLERFLHDYEGTVVAITHDRYFLDNVAGWILELDRGEGIPWEGNYSSWLEQKEKRLEQEQATENARQKSIAKELEWVRQNPKGRQAKSKA------MARFDELNSGEYQKRNETN-ELFIPPGPRLGDKVIEVQN-LTKSYGDRTLIDDLSFSIPKGVGIIGANGAGKSTLFRMLSGQVVLASVDQFRDSMVGELSGGERGRL--HLAKLLQRGGNVLLLDELD-----------------VETLRALENAILEFPGCAMVISHDR.............................................................................................................................................. 502
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Alonso A, Rahmouni S, Williams S, van Stipdonk M, Jaroszewski L, Godzik A, Abraham RT, Schoenberger SP, Mustelin T. Tyrosine phosphorylation of VHR phosphatase by ZAP-70. Nat Immunol. 2003 Jan;4(1):44-8. Epub 2002 Nov 25.