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Query: [O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVERRNPLVLSSTRSTLRSVLNSSQPSSADGDRVLNKDGDLLRGNARLSAGILRWRKDGENVSDAKLDSLDDSALVGLSTQLLKRLSINSGSLVCPSHLVQSTKLDLFWIILLLLMLTIEFLKCKVVVKNIEIGIQRVAQVVVLDPPKTTLEDASLTQVPVSDSLHTMLVFPTYDLMGQQLLDQEVAYLSPMLAFNLSLHISCLKSLVHRGNGVLEKYFEAKCDEEFIGKSAEDGSKIGLDLEPVSQVPGYASHLRVSFVKIPECGTIPSLKVNSSFEAEERQGLIDSALQKYFGTDRQLSRGDIFRIYIDWNCGSSICNPCSQRLCSESDDYIYFKVIAMEPSNERFLRVNHSQTALVLGGTVSSGLPPDLLVYRSKVPMPLQEETVNILASVLSPPLCPSALASKLRVAVLLHGIPGCGKRTVVKYVARRLGLHVVEFSCHSLLASSERKTSTALAQTFNMARRYSPTILLLRHFDVFKNLGSQDGSLGDRVGVSFEIASVIRELTEPVSNGDSSMEEKSNSNFSENEVGKFRGHQVLLIASAESTEGISPTIRRCFSHEIRMGSLNDEQRSEMLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTKALDRSKKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSSGLRKRSGVLLYGPPGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPCVIFFDELDSLAPARGASGDSGGVMDRVVSQMLAEIDGLSDSSQDLFIIGASNRPDLIDPALLRPGRFDKLLYVGVNADASYRERVLKALTRKFKLSEDVSLYSVAKKCPSTFTGADMYALCADAWFQAAKRKVSKSDSGDMPTEEDDPDSVVVEYVDFIKAMDQLSPSLSITELKKYEMLRDQFQGRSSLast
1 -172.000[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali  100  1MVERRNPLVLSSTRSTLRSVLNSSQPSSADGDRVLNKDGDLLRGNARLSAGILRWRKDGENVSDAKLDSLDDSALVGLSTQLLKRLSINSGSLVCPSHLVQSTKLDLFWIILLLLMLTIEFLKCKVVVKNIEIGIQRVAQVVVLDPPKTTLEDASLTQVPVSDSLHTMLVFPTYDLMGQQLLDQEVAYLSPMLAFNLSLHISCLKSLVHRGNGVLEKYFEAKCDEEFIGKSAEDGSKIGLDLEPVSQVPGYASHLRVSFVKIPECGTIPSLKVNSSFEAEERQGLIDSALQKYFGTDRQLSRGDIFRIYIDWNCGSSICNPCSQRLCSESDDYIYFKVIAMEPSNERFLRVNHSQTALVLGGTVSSGLPPDLLVYRSKVPMPLQEETVNILASVLSPPLCPSALASKLRVAVLLHGIPGCGKRTVVKYVARRLGLHVVEFSCHSLLASSERKTSTALAQTFNMARRYSPTILLLRHFDVFKNLGSQDGSLGDRVGVSFEIASVIRELTEPVSNGDSSMEEKSNSNFSENEVGKFRGHQVLLIASAESTEGISPTIRRCFSHEIRMGSLNDEQRSEMLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETKKINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTKALDRSKKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSSGLRKRSGVLLYGPPGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPCVIFFDELDSLAPARGASGDSGGVMDRVVSQMLAEIDGLSDSSQDLFIIGASNRPDLIDPALLRPGRFDKLLYVGVNADASYRERVLKALTRKFKLSEDVSLYSVAKKCPSTFTGADMYALCADAWFQAAKRKVSKSDSGDMPTEEDDPDSVVVEYVDFIKAMDQLSPSLSITELKKYEMLRDQFQGRSS 973
2 -102.000[O] COG0464 ATPases of the AAA+ class  ali follow..  24  16................................................................................................................................................................................ADQRDVGKGIVRIDERFREKLGLKPFDVVEIKGGKSTSALIGRPYPSDAGLDIIRMDGLIRTNAKT-------SIGEYVDIRKADWKEAKSVTFAPVAQGMQIYAPSETLKAVFMN-----RTVSKGDFISTTSLRRSRERETFGKGVMFEDFFQDFFGQGFGQVVSTAPAGIVKITDMTQVELLPEAMEIISEQNIPTVMYEDLGGLKDAISKVREMIELPLKHPELGIDAPKGVLLQGPPGTGKTMLAKAVANESDAYFISINGPEIMSKYYGESERAIREIFEDAEKNAPAIIFLDEIDSIAPKRAEVTGE-----VERRVVAQLLSLMDGLKARK----------------------NVIVIGATNRPEALDIALRRPFDREIELRVPDTEGRLEIFQIHTRGMP----LADNVNLMDFAQITYGFVGADIAALCREAAMSALRRILPKINLNE------------PEISKEILDALQVTREDFENALKDVQPSAIREI-LIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDGVEAPKGVLLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPSIIFLDELDSLAPIRGTSVGEPQVTARILNQLLSEMDGL-EELRAVVVIGATNRPDIIDPALLRPGRFDELILVPV-PDEGARREIFRVHTKNMALAEDVDIEKLVSFT-DQYTGADIAAVCKKAGRHALREDLH---------------AKKVRQKHFLQAIEETGPSVTPDTMKYYEAIKGELRKR.. 753
3 -101.000[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  28  132..................................................................................................................................................................................................................................................................................................................................................KKSVGQESITGSAKRKDRRSKTNGSKRQKAEAEPPSDISLSDIGGLDDCINELLELVAMPIKHPETGIHPPRGVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSGMSGESEKKVREVFEEAKSLAPCLMFIDEIDAVTPKRESAQR-----EMERRIVAQFLTCMDELSFEKT------------------DGKPVLVIGATNRPDSLDSALRRAFDREICLTVPSQDAREKILRTMAKGLK----LSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSYLNAHPDPLSPEELEPLAICPQDFIEALAKVQPSSKRE-GFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDS--LSEASSRVVNTLLTELDGLSD-RSGVYVIAATNRPDIIDPAMLRPGRLDKTLLVDL-PDAHERVEILKTLTKQTPLHEEVNLDVLGDERCSNFSGADLAALVREAAVTALRSAVFADIASNEITQHSALEPIRVTNADFELAFKNIKPSVSDRDRQKYQRLAKRWSSAST 775
4 -96.800[O] KOG0730 AAA+-type ATPase  ali follow..  28  66................................................................................................................................................................................DEAINDDNSVVSLHPTTMEKLQLFRGDTILIKGKKRKDTVALADETCEEPKIRMNKVVRSNLRVRLGDVISVHQCPD--------VKYGKRVHILPVDDTVEGVTGNLFDAYLKPYFLEAYRPVRKGDLFLV-------------------RGGMRSVEFKVIETDPAE---YCVVAPDTEIFCEGEPVKREDEERLDEVGYDDVGGVRKQMAQIRELVELPLRHPQIGVKPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESESNLRKAFEEAEKNAPSIIFIDEIDSIAPKREKTNGE-----VERRIVSQLLTLMDGLKSRA----------------------HVIVMGATNRPNSIDPALRRFFDREIDIGVPDEIGRLEVLRIHTKNMK----LAEDVDLERISKDTHGYVGADLAALCTEAALQCIREKMDVIDL------------EDDSIDAEILNSMAVSNEHFHTALGNSNPSALRET-VVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFEKGMSPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVREIFDKARQSAPCVLFFDELDSIATQRGNAGDAGGAADRVLNQLLTEMDGM-NAKKTVFIIGATNRPDIIDSALLRPGRLDQLIYIPL-PDEDSRLNIFKACLRKSPVAKDVDVTALAKYT-QGFSGADITEICQRACKYAIRENIEKDIENAMEEDMVDDEVSEIRAAHFEESMKYARRSVSDADIRKYQAFAQTLQQS.. 802
5 -79.900[O] KOG0741 AAA+-type ATPase  ali follow..  16  214......................................................................................................................................................................................................................................................................................................................................................................................NFEKMGIGGLDKEFSDFRRAFAFRVFPPEMGCIHVKGILLYGPPGCGKTLLARQIGKMLNAREPKVNGPEILNKYVGESEANIRKLFADAEESGLHIIIFDEIDAICKQR---GSMAGSTGVHDTVVNQLLSKIDGVEQLN----------------------NILVIGMTNRPDLIDEALLRPLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIKASTK--------------VEVDMEKAESLQVTRGDFLASLENDIKPAFGTN-QEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNS--DRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKQAMKKIFDDAYKSQLSCVVVDDIERLLDYVP---IGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDVLQEMEML-NAFSTTIHV---PNIATGEQLLEALELLGNL-KDKERTTIAQQVKKVWIGIKKLLMLIEMSLQMDPE---------------------YRVRKFLALLREEGASPLDFD................ 744
6 -76.100[O] KOG0737 AAA+-type ATPase  ali follow..  22  61......................................................................................................................................................................................................................................................................................................................................................................................SVTFDEFPYYEKTRLLLTSAAYVHLKQSDISAPGSKAILLSGPADTEQVWMRQERTWTLRRHTSGNDLHSRGFDVTSQPPQSLYKVLVSISETNPIIIYLRDVEKLCQSE--------------RFYKLFQRLLTKLSG------------------------PVLVLGSEDDCQEVGEGISALFPYNIEIRPPEDENQLMSWKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSSNSLSHGLNILQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEH-EAMRKIKNEFMTHWDGLSNAGDRILVLAATNRPFDLDEAIIR--RFERRIMVGL-PSVESREKILRTLLSKEKT-ENLDFQELAQMT-DGYSGSDLKNFCTTAAYRPVRELIKQSEAKEEVSEERGITLRPLSMEDMKVAKSQVAASFAWNDLYGEGGSRKK...... 719
7 -62.200[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  25  2...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SLEELEAMDQSNPGEFLERVREKIRMLNSETRILQSRVNTITKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSYLPITGLIPNSELRPGDLVALHKDTNIVFEKLPPDYDMKVGGMVLKSD-----AKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKNIKPPKGVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPTIIFIDEIDAIGAKRSDSDQTGDEVQRTMLELLNQLDGF-SSSEEVKIIAATNRVDILDPALLRSGRLDRKIEFPL-PNTLGRKRILQIHARKMSVRDDVNFDELARST-EGFNGAQCKAVCVEAGMAALRK-----------------EKTEISQNDFMDGIQEVLSRKKSK................. 396
8 -61.900[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  26  1.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTVTNRMEIESAYHKGE--EELQLVVAEKHQNLRRLQAQRNELNAKVRMLREE---QLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVVDLDKNID-------INDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDAGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRIESGSGGDEVQRTMLELLNQLDGF-EATKNIKVIMATNRIDILDPALLRPGRIDRKIEFPP-PNEEARLDILKIHSRKMNLTRGINLRKIAELM-PGASGAEVKGVCTEAGMYALRE-----------------RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK........ 405
9 -61.600[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  25  12......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DPKASPALMDLSTAD-EEDLYGRLLERQLEFTDIQEEYVKDEQKNLKRELLRAQEEVKRIQFMEMVDQNNGIVGSTTGSNYYVRILSTINR-------------------------ELLKPSASVALHRHSNALVDVLPPEADSLSQSEKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATARFDAQTGADEVQRILMELLNQMDGF-DQTVNVKVIMATNRADTLDPALLRPGRLDRKIEFPL-PDRRQKRLVFQVCTSKMNLSDEVDLEDYVSRP-DKISAAEIAAICQEAGMHAVRK-----------------NRYVILPKDFEKGYRANVKK-PDTDFEFYK........... 408
10 -61.000[O] KOG0740 AAA+-type ATPase  ali follow..  28  324.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELI-MDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHES--SRRIKTEFLVQLDGATTSSEDILVVGATNRPQEIDEAARR--RLVKRLYIPL-PEASARKQIVINLMSKEQCLSEEEIEQIVQQS-DAFSGADMTQLCRGASLGPIRSLQTADIATITPDQVRP-----IAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK. 674
11 -61.000[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  24  1.................................................................................................................................................................................................................................................................................................................................................................................................................................................................MGQNQSAQGGAGEKKDDK-------DKKKKYEPPIPTRVGKKKRRAKGPDAAMKLPQVTPHTRCR----------------------------LKLLKLERIKDYLMMEFIRNQERLKPQDEKNEEERSKVDDLRGTPMSVG---NLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDQLEPGCSVLLNH--------------------KVHAVVGVLSDDTDPM-VTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRYDSNSGGEEIQRTMLELLNQLDGF-DSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPL-PDEKTKRRIFTIHTSRMTLAEDVNLSELIMAK-DDLSGADIKAICTEAGLMALRE-----------------RRMKVTNEDFKKSKESVLYRKKEGT................ 433
12 -59.900[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  25  5.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QFSNMVEPTGPAIVEDSYRRKECRDIEQKLKDLRKKESEMT---------KQFDKSENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNGPRYVVGCRRSIN-------KEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRRFSEGTSADEIQRTLMELLNQLDGF-DSLGKVKVIMATNRPDTLDPALLRPGRLDRKIEIGL-PNEQSRLEILKIHSNKITKHGEIDFEAVVKLS-DGFSAADLRNVCTEAGMFAIRA-----------------EREFVIDEDFMKAVRKVGDAKRLETKLDYKPV......... 406
13 -59.000[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  26  2...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PDYLGADQRKTDEKDDKPIRALDEGDIALLKTYGQSSRQIKQVEDDIKINELTGIKESDTGLAPPALWDLAADKQTLKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDEVQRTMLELINQLDGF-DPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSL-PDLEGRTHIFKIHARSMSVERDIRFELLARLC-PNSTGAEIRSVCTEAGMFAIRA-----------------RRKIATEKDFLEAVNKVIKSYAKFS................ 424
14 -57.300[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  27  21.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STEDITRATLDNEIRI-------KEDAQRTNLECDSYKEKIKENQEKIKLNKQLP-YLVGNIVEILEMNPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDSLKPGLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTKRFDSEVSGDEVQRTMLELLNQLDGF-SSDERIKVIAATNRADILDPALMRSGRLDRKIEFPH-PTEEARARILQIHSRKMNVHPDVNFEELARST-DDFNGAQLKAVCVEAGMLALRR-----------------DATEVNHEDFNEGIIQVQAK-KKASLNYYA........... 424
15 -51.200[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  31  297..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GIFNIGKATITRADKHSKNKIYFKDVAGCDEAKQEIMEFVHF-LKNPKKYEDGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPSRVRHLFQEARQAAPSIIFIDEIDAIGRARGRGLGGNDERESTLNQLLVEMDGF-GTTAGVVVLAGTNRPDILDKALLRPGRFDRQITIDK-PDIKGRDQIFKIYLKKIKLDHEYYSQRLAALTP-GFAGADIANVCNEAALIAARHEGAT-----------------VTMAHFESAIDRVIGGLEKKNRVISKLERRTVAYHES 586
16 -50.200[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  32  266.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTIGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPY-SRQTINQLLAEMDGF-KPNEGVIIIGATNFPEALDNALIRPGRFDMQVTVPR-PDVKGRTEILKWYLNKIKFDQSVDPEIIARGTV-GFSGAELENLVNQAALKAAVDGKEM-----------------VTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHES 544
17 -50.200[O] KOG0739 AAA+-type ATPase  ali follow..  28  107............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KKLQEQLMGAV-VMEKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTGKRTPWRGILLFGPPGTGKSYLAKAVATEANSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNENESEA--ARRIKTEFLVQMQGVGNNNDGTLVLGATNIPWVLDSAIRR--RFEKRIYIPL-PEEAARAQMFRLHLGSTPHNTDANIHELARKT-EGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNPSMMVCMSDMLRSLATTRPTVNADDLLKVKKFSEDFGQE.. 436
18 -50.100[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  28  88................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEY-LRNPEKF--GKWAPKNVLFYGPPGTGKTMMAKALSNEAKTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPCIVFLDEFDAIALDRGYQEIRGD-VSEIVNALLTELDGT-NSNEGICTIAATNRVELLDASI--RSRFEEEIEFRL-PSYEERLEILRRNLEEFPVPVKARLELVAAASE-GFSGRDLVEKVIKASLHKAIA----------------EGKDKIETEDLLTAAEKVKMPSRQPP................ 347
19 -48.400[O] COG0465 ATP-dependent Zn proteases  ali follow..  34  136.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KSKARMLTEDQIKTSFADVAGCDEAKEEVSELVDY-LREPSRFQKGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGGGGHDEREQTLNQMLVEMDGF-EGNEGIIVIAATNRPDVLDPALLRPGRFDRQVVVGL-PDVRGREQILKVHMRRVPLDTDIDASVIARGTP-GFSGADLANLVNEAALFAARGNKRV-----------------VSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEA 416
20 -39.000[O] KOG0743 AAA+-type ATPase  ali follow..  15  219................................................................................................................................................................................................................................................................................................................................................................................................KKIIDDLERFLKRKEFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSIYD------NGELKRVLLSTTNR--SILVIEDIDCNAEVRDREAENQEDEQIKGKVLSGILNFIDGLWSS--------------------FGDERIIVFTTNHKERLDPALLRPMDVHINMSYCTGLGFRTLVSNYLGLDGLNHPLCEEIE----LVDSTEVTPAELAEMQDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQLTMVIDEIIGFLRNKIGPETARLRVGKLPK-GWGCIN--PGAKKKIIDDMERFLKRREFYKRGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSI------YENAQLKSILLSTTNR--SILVIEDIDCSSAEVVDREADEYQEYETLSGLLNFVDGLSSFGDERIIVFTTNHKERLDPALLRPGRMDMHINMSYCTGLG-----FRTLVSNY-LGLGGLNHPLCEEIEAEVTPAELAEELTDVVLRGVVSFVENRKVEISKTKELEGSTCRKLDGDDKHNVSSTNDLKKTKKKKKGGKGKAK...... 994
21 -23.600[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  14  48.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HLPDPHTFPLVRLAGVGRQTELLVRNT-------EQFIVG-RPANNVLMSGARGTGKSSLVKALLHEYADKGLRL---EVDKSDLIGLPYLLTLL---KECPEKFIVFCDDLSFESGDETYKA-DGGLSQRCANVLVYATSNFDENAGTTGMRGEIHQKEAVEEKISLSDRFGLWLSFY-PFDQNDYLAAVQNWLEDFGVPYDETAQMAALQWAGSRSGRSAWQFACDWAGRLPKQR......................................................... 285
22 -19.400[K] COG1224 DNA helicase TIP49, TBP-interacting protein  ali follow..  11  1................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAGEIREITQTFERIAHSHIRGLGL---ENLRAKDVADGLVGQKRAREAAGVI---VRLIKSGKMAGRGILMAGPPGTGKTAIAVAISKELGIPFVQVSASEFYSAEMKKTEALIQAMRKAVRIRETRTVLEGEVVGLDYNMVPNPYNP--TQKIPESATLTLATKDEKRGGRLAMQFFTQGIEVGDVIVIDKETGRIGKLG---RSEKAKKKYDLGDDEVVPVPSGKVEKEKEFT--TLHDLDEANARRTSIFSLFSPPSREIDNEVREAVDEQVKRLVEEGRAELVPGVLFIDETHLMDIELFAFMNRAMESEMA 317
23 -18.800[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  14  175........................................................................................................................................................................................................................................................................................................................................................................................KLDPVIGRDEEIRRAIQVLQR---------RTKNNPVLIGEPGVGKTAIVEGLAQRINKRVLSLDMGALIAKYRGEFEERLKAVLNELSKEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLA----------------------------------RGELHCVGATTLDE--DAALERRF-QKVFVGEPTVEDTIAILRGLKERYEIHHHVQTDPAIVAAATLSHRYVSDKAIDLIDEAASSIIKAELDSAKTQMEQARRASDFAKMSELQYGVIPALEKQLAQAESAEGKEMTLLRYRVTDEEIAEVRATGI-GQHEAIEAVSNAIR---RSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLANFLENAMVRIDMSEFMEKYVGYEEGG--YLTEAVRRRPYSVILLDEVEKAHH------DVFNILLQVLDD-LTDGQGRTVDFRNTVVIMTSNRPEFI-------NRIDETVVFH-PLGKENIREIATIQLARLI--TDACLDFIGEVGYDPVYGAPLKRAIQQEIENPLAQQI........................................................ 831
24 -18.300[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  16  179........................................................................................................................................................................................................................................................................................................................................................................................QLDPVIGREDEIRRTIRVLSRRTKNNP---------VLIGEPGVGKTSIAEGLARRINCKLLSLDVGSLVAKFRGEFEERIKSVLKEVEESTPIILFVDEMHLLMGAGSGGEGGMDAANLLKPMLA---------------------------------RGKLHCIGATTLAE--DAAFERRF-QIILVKEPSIEDTISILRGLKEKYEVHHGVTSDRALVTAAHLASRYLTSSAIDLVDEAAAAVRVTRESQPEVLDNLERKLRQLRVEIRALEREKDE-KADAEAIANAQPGSEPLLIDVVGPDQINEIRWTGI-GQNEAVTAVANAI---RLSRAGLSDPNQPIASFLFCGPSGTGKTLLTKALASFMENAMIRIDMSEYMEKYVGHEAGGQ---LTEQLRRRPSVILFDEIEKAAP------EVLTVLLQVLDD-ITSGQGQVVDAKNAVIIMTSNRPEFL-------NRISSIVIFN-RLRRVDIRNIVENRILEVQ--SDEAKDLLGSAGYSPAYGAPLNRVIQNQVLNPMAVLIGQLRDKETAHVVVQNGKIFVKPNHEANANGSADIDMDGID................ 896
25 -18.200[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  14  242.................................................................................................................................................................................................................................................................................................................................................................................................................................EKTTPPSATGEKQKKGIIMVRTENVVAEPVPKNNETKATMMAIVQTIRDVVQFNQLFGQ-QINLLLHPSQNVIDNPVYLCDLVATLVQSA----------ETKDLQEMMDEIDVSKRLKIALLLIQKEKAVAKLKYDINKDVEKKV-----QDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSE-------------------FSVTRNYLEWLTSVP--GLTSPENRRLSVAKKALDEGHYGMKDVKERIMEFIAVNLLRKSIGGK-------LCFHGPPGVGKTSIAKSIATALNREYFSVGGAEI-RTYVGAMPGKMIQCMKKVKTENP-LVLIDEVDKIG-GAGFHGDPA-------SALLELLDDVPVDLSRVLFICTANEISKIPGPLR-----DRMEMIDVS-LAEEKVEIAHQHLEQLKIEDSALEELIKHYCRE--SGVHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAVCTENLQKF............ 770
26 -17.400[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  15  382.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KAKATLLLATRP----KSLPCRSKEMEEITAFIK------GSISDDQCLGRCMYIHGVPGTGKTISVLSVMKNLKINGLKLASPVIYEGLSGHRVGSLNERFAEKENEKPCILLIDELDVLVTRNQ-------------SVLYNILDWPTKPNSKLVVLGIANTMDLPEKLLPR-SRMGIQRLCFGPYNHRQLQEIISTRLEGINAFEKTAIEFASRKVA-AISG-DA-----RRALEICRRAAEVADYRLKKSNISAKSQ-LVIMADVEVAIQEMFQAPHIQVMKSVSKLSRIF..... 677
27 -16.600[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  17  296......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IKQHKIPAINEDGLFYLITHLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQIWTSKYAPTSLKDICGNKGVVQKLQKWLQ---NFNKPGPDGLGLYKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASD-------RSKRLLDEQLFGVMAKSRLVLIMDEIDGMS-----SGDRGG-----VGQLNMIIKKSMIP-----IICICN--DRAHPKL-RP-RFRR-------PDANSMRSRIMSIAYREGLKLSPQVDQLVQG-----TQSDMRQIINLLSTYKLSCS--------EMTPQNSQAVIKNSEKHIVMKPWDICSRY.................... 621
28 -16.200[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  11  134......................................................................................................................................................................................................................................................................................................................................................................................................LTKSTQENLNRITPYLVQKRPILLAGPEGIGKKFLITQIAAKLGQQIIRIHLSMLIGTYTSPKPGEFEGVLTQAVITGKWIL-FTNIEH----------------APSEVLSVLLPLLE-----------KRQLVIPSRGETIYAKGSFQMFATSSMKTK---ILGQRLW-QILDLTYQPDECVEVVSTLYPVLSIICPTLYSVYKDIFDLFSQ-LCLRDFYKFIKRVAFLYHKFMIPSDHVVISQEGAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIGRCSLKKLSTIRSCSTNSYAFTSSSLGLLEQLAAGVQTNEPLLLVGETGTGKTTTIQLLAGLLGQKVTVINSSDMLGGYKPINASTCLKIWKEACKLSKTVLDGQQPLPNPQKRQKRLSNQVELRNQWAKFEKEVEDFEKVVEGALVKAVRSG--LLDEILASLETLEPIGQL----SSYESGILLSERGDITPITPHKNFRLFGCMNPSTDVG-------KRELEPSFRSRFTEIYVHSPDQNLDDLLSII---QKYIGSLCIGNEHVIREVAELYQVAKSLSLDGS. 763
29 -15.500[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  17  155..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKPIEKMDSIDQLIGYVMPYMPIKLELEIVSVRERYFILMKQKENINFQMEMAKKVTDKISKSNREAMLREQLKMIQEESGEGGYRERIEKSTMPEEVKKKALSELKKLETGGPHNPESSVIRNYLDLMLD--VTEEKKSIDIDEARRVLESNHNGLEKVKERIIQHLAVMKLKKEKQGS-------LLLTGPPGTGKTSLGKSIADALGREYISLGGAEIRGTYIGALPGRIIQGMRKAGTKNP-VFILDEVDKLS--TSYAGDPA-------SALLEVLDEVPYDLSEVFFIATANSLASIPWPLL-----DRMETIEIS-TKNEKLAIAKDHLLPCILEEH-GLDADKLKIEDEALKGIIDKYTREAGVRGLKKQLARTFVSEKIVSGKTDLPYVVRADMLKEVL........................... 582
30 -14.100[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  12  554.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GHMDEQTKLYQWVRQTIVLGE--------GNSVIIVGPRGSGKSVLVDDILSRAKSYVVRLNG-EISRQLFSDTLTKLLATLSHPTTSAAVIFVLEEFDLFVQHS---------RQMLLYNLF---DIAQSRKAPILIIGLTTRYDCSESLEKR-SRFSMVIPMRPPSSLSEFEQILKSVLYVSDEGGKDQIITCWNQRVDELLSDTRSHL---QHHYFASRNLKLLYVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELAL..... 855
31 -13.300[V] COG1401 GTPase subunit of restriction endonuclease  ali follow..  19  201.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KNDIGLIGSETALPEDEQDEEVTTPQLPKNTILYGPPGTGKTYCTIELAVRARVRFITFHQSFGYEEFI-TDDGNVKQICEDAAKRQNYVLIIDEIN-----RGN-------ISKIFGELITLIEGEPEALNNLYLIGTMNTADALDTALRR--RFE---FEAMLPDI----TVLKETV------KGIDLPRLLQTLNDRIE--DREHTLGHAFFIPVVQVKEDEDL---------------AFERLKRIMRKVLPLLEEYFYNDWQKIRMVLGDN.. 617
32 -13.100[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  17  12...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VINDEESIDRAIRPK-------------LLTEYVGQPHVREQMEIFIQAAKQRGDALDH-------VLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVL------EKAGDLAAMLTNLEPHD--VLFIDEIHRLSPVVEEDYQLDIMIGEGPAARSIKLD-----LPPFTLIGATTRAGSLTSPLR--DRFGIVQRLEF--QVADLEHIVSRSAKCLGLELTPEAHQLARRS----RGT------PRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNVDAE------GFDFMDRKLLLAVIDKFMGGPV 281
33 -12.700[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  14  63..............................................................................................................................................................................................................................................................................................................................................................................................................................................................EDLIAIARSGLENLFRQVAGQNYVLLLSDREGVTVEFLGDPLFGNSLRKAGLYLGSEWSEWRAGTCAVGACLETGEALTIHQTDHFDNTHTPLSLSAVLDISLLSSPILKASQNLALHLVSATVRRIELAN--LMAQARNQWVLRFSRSPEFLDVDPEAAISIDGLGRIAGMTHAGAKILARSTGLDWRDPQQLIGEPVSRFFDIEVDNLSDLTRNALFAHAIEPHSKVRAPLVSREQIPPALRRLGGDAPVIAALQAKAA----------KLARTRLPILIQGETGTGKEHLARAIHEGSGLEFVAIN-SELFGAFTGASAKGRKGLIEQADGGT---LFLDEIGDMP----------ALQSRLLRVLVLPVGGTAPRKVRIRIVSASHR-PL--QTLVSQGAFREDLYLTLPADRPDFDWVLEQLLKRHGDGEILSPAALSALKAHDWPGRELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGNEASATLSLTLTACNWNISEAA---HRQIKR....... 619
34 -12.600[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  11  20........................................................................................................................................................................................................................................................................................................................................................................................................................................FARMLASVLQLEVEIVDENLYRVAGTGAYGKFLGRQLSGNSRLLCHVLETKTEKVVTQSRFDPLCEGCDSKENCREKAFLGTPV------------------------ILQDRCVGVISLIAVTHEQQEHISDNLREFSDY-----RHISTIFVSKLLEDQGPGDNISKIFATMIDNMDQGVLVVDDESRVQFVNQTALKTLGVVQNNIIGKPIRFRPLTFESNFTHGHMQHIVSWDDKSELIIGQLHNIQGRQLFLMAFHQSHIEQLVGECRVMRQLKRLIS----------RIAPSPSSVMVVGESGTGKEVVARAISGRRNKPFIAIN-PEQLGAFTGASANGKTGLIQAANTGT---LFLDEIGDMPLMLQAK--------RAIEA-ILPIGASSPIQVDIRIISATNQ-NL--AQFIAEGKFREDLFITLPPLRERQEDIVHYFLHLHTRRLGSVYPGIAPDVKHRWPGRELSNLMEYLVNVVLPPNLLNNGTTEQSDVTEVTEAHLSLDDAGGTALEEMEKQMIREALSRHNSKKQVAD.... 571
35 -12.500[Z] COG5245 Dynein, heavy chain  ali follow..  12 1354................................................................................................................................................................................................................................................................................LTKIIERAQKEFVIEKSLNRHSSGLKLVREWDVLEQACKEDLEELVSMKASNYYKIFEQDCLDLESKLTKLSEIQVNWVEVQFYWLDLYGILGENLDIQNFLPLETSKFKSLTSEYKMITTRAF-------------------------QLDTTIEVIHIPNF----DTTLKLTIDSLKMIKSSLSTFLERQRRQFPRFYFLGNLKIIGSGKH-----------HDQVSKFMKKMFGSIESIIFL-EDFITGVRSVEGEVLNLNEKIELKDSIQAQEILDTEIKLSVFTQFRDCLGQLKDGTDIEVVVSKYIFQAILLSAQVMWTE-----------LVEKCLQTNQFSKYWK--EVDMKIKGLLDKLNKSSDNVKKKIEALLVEYLHFNNVIGQLKNCSTKEEARLLWAKVQKFYQKNIGIPERL-------IYTPLLLI-TLTDSLHQKYGGCFFGPAGTGKTETVKAFGQNLGRVVVVFNCDDSFD-------QVLSRLLV-TQIGA-C---FDEFNRL---------DEKVLSAVSANIQQIQNGLQVGKSHITLLEEE-----LSPHT---------VFITLNPGYNGRSELLKKSFREFSMKPQSGTIAEMILQIMGFEDSKFLELLSSKGLRTLKGVLRNC--SPLISEFGEGEKTVVES.................................. 1997
36 -11.900[L] KOG0477 DNA replication licensing factor, MCM2 component  ali follow..  18  380............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVANHVAKKDNKVAVGELTDEDVKMITSLSKQQIGEKIFASIAPSI------GHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAFTTGQG----ASAVGLTAYVQRH--EWTLEAGALVL-IDEFDKM-----NDQDRTSIHEAMEQQSIS---GIVTSLQACTVIAAAN-----------PGRYDPSL-VDLTEPIISRFDILCVVRDTVDPVQD---EMLARFVVGSHVRHH-----PSNKEEEGLANGSAAEPAMPNTYGVEPLPQEVLKKYIIYAKERVHPKLNQMDAKMYSDLRKESMATGS 759
37 -11.700[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  21  52........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EVQEAQAESSGHKLPAPKEIRTILDQYVIGQERAKKVLAVAVY--LNQRDKKDDIELGKSNILMIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAYVGEDENIIQKLLQKCEKAQMGIVYIDEIDKISRKSDNPSITRDVSGEVQQALLKLIEG--DTRNILFICGGAEPEDLVKFGLIPEGRLPVIATLD-ELDEAALMQILTEPKNDLEFRPDA-LKAVARKALERKTGAGLRSILEGILLDTMYEIPSQQDVSKVVIDES........................................... 401
38 -11.700[L] KOG0480 DNA replication licensing factor, MCM6 component  ali follow..  12  281.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VRIQENSNEIPTGMPRTLDVILRVERAKAGDKCAFTGILILGIPGVKPEAYRDSRNFGGRDADGVTGLKSLGVRDLTYKLSFLACMVQPDDANDKSGADVRGDGSQGIEEQDEFLQSLSQEEIDDLRAMVHDHIYSRLTNSLAPSV------GHEIIKKGILLQLMGGVHKLTPEGINLRGDLNICIVGDPSTSKSQFLKYVCNFLPRAYTSGKA----SSAAGLTAAVVKD--DFTIEAGALML-IDEFDKM-----DLSDQVAIHEAMEQQTIS---GIQATLNATSILAAANRYN-MSAPIM--SRFDLFFVVLDECNESVDRHLAKHIVDIHRLRDDAMQPEFSTEQLQRYIARTFKPKLNTESCAEIVKKYKQLRMDDAQGAGKNSYRITVRQLESMIRLSEAIARANCVDDITPAFVNEAYS.... 730
39 -11.500[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  14  40.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VIDRLELLHDARSRSLFETLKRDIASVSPETEVVSVCLHDFARGYEFQPEKEDYLIHITTGTHVAQICWFLLAEARYLPARLIQSSPPRKKEQPRGPGEVTIIDLD---LSRYNAIASRFAEERQQTLDFLKSGIATRNPHFNRMIEQIE---------KVAIKSRAPILLNGPTGAGKSFLARRIRHQFSGAFVEVNCATLRGDTA-MSTGHVKGAFTGARESRE-MLFLDEIGELGAD---------EQAMLLKAIFYPFGSDRQVSSDFQLIAGTVR-DL--RQLVAEGKFREDLYFTLPGLRQRQEDILDYEVERHASLTGDSVRFNTEARQATWRGRELSASVTRMATFAVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQ... 493
40 -11.400[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  10  6...................................................................................................................................................................................................................................................................................................................................................................................................................................................................FCEDRLGLTRELLDLLVLRSIDLRGIEIDPIGRIYLNFAELEFTDFSSLMAEIRRISGVTDVRTVPWMPSEREHLALSALLEALPEPVLSLDMKSKVEMANPASCQL----------------------------------------FAQSQERMRHHTAAQLINGFNFQRWLDGNPQSSHNEHVVINGQNFLMEITPVHLQNENDEYVLTGAVVMLRSTIRMGQQLQNLSTQDLSAFSQIIAVSAKMKHVVEQAR----------KLAMLSAPLLITGDTGTGKDLFAYACSPRSAKPYLALN-PEVESELFGHAPEGKKGFFEQANGGS---VLLDEIGEMSPR---------MQAKLLRFLFRRVGEDHEIHVDVRVICATQK-NLVE--LVQKGLFREDLYLNLPPLRDCPQDITELFVARFADEQGVPRPKLSADLRYGWPGRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMESLDDITSRFERSVLTQLYRSYPSTRKLAK.... 488
41 -11.400[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  12  13......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VIWTVSVTRLFELFRDISLEFDHLANITPIQLGFEKAVTYIRKKLANERCDAIIAAGSNGAYLKSRLSVPVILIKPSGYDVLQALAKAGKLTSSIGVVTYQETIPALVAFQKTFNLRLDQRSYITEEDARGQINELKANGTEAVVGAGLITDLAEEAGMTGIFIYSAATV----------------RQAFSDALDMTRMSLRHNTHDATRNALRTRYVLGDMLGQSPQMEQVRQTIL------------ARSSAAVLIEGETGTGKELAAQAIQGKKSHPFVAVN-AELFGAFTGSRRGGRAGLFEIAHGGT---LFLDEIGEMPLPLQTR--------RVLEE-VTRVGGHQPVPVDVRVISATHC-NL--EEDMRQGQFRRDLFLQLPPLRERVADILKVSLAALSAPFSAALRQGLQASHYDWPGRELRNMMERLALFLLQLLLPELARESAKIPAPRLLTPQQALEKFNGDKTAAANYLGISRTTFWRRLKS....... 528
42 -11.200[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  12  34........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RLVQDEVRDNLTRKLRSGEEL---FPGVVGYDDTVIPQL--------------NALLARQNFILLGLRGQAKSRILRAITELLDPEVPVIDGPDVTADLIGDPIKAARRSMHFG-RANRGIFAVNELADLSP-------------KVQVALFVQIKGYPIRLELDVMLVFSANPE-IVTPLK--DRIGSEIRTHYPTDVQLGMDITAVKEEGVVVPPFI-IEDIAFQAREDGRIDKLSGVSQRLPISLMELACANAERRSL-----SGDAPVVRVTDVYAGLPAITGKMELEYEGELKGADNVAKD... 378
43 -11.200[A] KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1)  ali follow..  12  411................................................................................................................................................................................................................................................................................................................................................................................................SSQSNAVSHVLQRPL------------SLIQGPPGTGKTVT--------------------------------------------------------------------------SATIVYHLS------------------------KIHKDRILVCAPSNAVDHLAAKLRDLGLKVVRLTAKSRED----------------------------------VESSVSNLALHNLVGRGAKGELKNLLKLKDEVGELSASDTKRFVKLVRKTEAEILNKADVVCCTCVGAGDKRL------DTKFRTV--IDESTQASEPECLIPIVK-----------KQVILVGGPGLKQSLFERLISLGHVPIRLEVQ-PYLSE-YEGSEQRTVPNSKFPWPIRGIPMMFWEEISANGTSFLNRIEAMNCE-RIITKLFR--DGVKPEQ------------------------------IGVITPYEGQRAYILQYMQMNGSLDKDLYIKVEVASVDAFQGREKDYII----LSCVR---ANEQQAIGFLRDPRRLNVGLTRAKYGLVILGNPRSLARNTL--WNHLLIHFREKGC 833
44 -11.100[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  10  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEP-------------VDKYKPETQ-------------HELAVHKKKIEEVETWLK---------RQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEWINP--FQKDDFKGMFNTESSFHMFPYQSQIAVFKEFLLRATKYNKMLGDDLRTDKKII--LVEDLPNQFYRDSHIFIISDSLSGDNNQRLLFPKEIQEECSISNISFNPVAPTIMMKFLNRKITVPDKTSLELLCQG-----CSGDIRSAINSLQFSSSKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVNQEVQAIGGKDLFLFRALGKILYCKRA 409
45 -10.900[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  15  167........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELENQAKQTQLRLEELNQEAWSRDSVEIIGNSGPMLAMKADID------------APSQFNILIHGETGVGKELVARTISNRKRQPLVYVNCAAIPENLL-ESEGHVKGAFTGADRARM-TLFLDEIGELPLS---------AQSKILRALIQPVGQDRVQTVDVRILAATNR-DL--KKEVEAGRFRADLYIYVPPLRERKGDLVEQARRKLGITLKLHGDVLSQLIQYPWPGRELEHVINRAALKAKARQRGRPV.................................................... 434
46 -10.800[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  17  112.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AVKEALHVSKAP----STILCREDEQIRIFEFVKGCIDQ--------QKAGSLYICGCPGTGKSLSMEKVVQQVGVNCTSLSKTKILGEIKPGKNQHLQNLFSQSSSSRMMLIIADEMDYLITKD----------RGVLYDLFM-----TLPFSRCILIGVANAIDLADRFLLKSLNCKPMVITFRAYSKDQILRILQERLRVLVAFQPKALELCARKVA-AASG-DMRKVCRSALEILEIETRGSTGPESQGPTPDDS---VVRMDHMAAALSKTFKSPVVETIQSLPQHQQII..... 414
47 -10.800[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  16  64...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AMGDDSSKRPNPKTQIHVAADDSNKRHKLSSSSHRQHQPLSERMRPR-------------TLDDVVGQDHLLSPLRSAVE-------------NRLPSIVFWGPPGTGKTSIAKSLINSSKYRFVSLSA-------VTSGVKDVRDAVESAKRLKRTVLFMDEVHRFNKSQ--------------DTFLPVIE-----DGSILFIGATNPSFHLITPLL--SRCRVLTLNPL--KPNHVETLLRRAVDDSERGLPNSVE----------VDDSVIEFLANNCDGDARVALNALEISATMATTRAGTDAVVSIDDAKEALQCKHLAYDKAGEQHYNLISALHKSMRG 359
48 -10.700[L] KOG0478 DNA replication licensing factor, MCM4 component  ali follow..  14  286..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ISISGMVIRSSNVIPEMREAINQPTLCTNCNTNHCFRLIHNRSEFTDKQLESPDDMAAGQTPHNVLLYAHNDLVDKVQPGDRVTVTGIYRATPLKTGGLSSFRKVDNKRLYEDEEGKDHIFPPERVELLQLLAKPDIYDRLARAIAPSI------ENDDIKKGILLQL-TKKKHATLGRQNFRSEIHLLLCGDPGTSKSQMLQYVFNLVPRSYTSGRG----SSAVGLTAYVTKD--QLVLQTGALVL-IDEFDKM-----NDSTRSVLHEVMEQQTLS---GIICQLNATSILAAAN-----------PSQWNKRK-VQLPHTLLSRFDLIFLVLDPQDEIFD----------------------------KRLASHLVSLYYVTRHEEEDTMFDMSVLRDYIAYAREHLSPTLSDEAIQAYVDMRKVGAGRGQ 728
49 -10.700[Z] COG5022 Myosin heavy chain  ali follow..  12  145.........................................................................................................................................................................................................................................................................................................................................................................................................AIAEDSYKCMNQEHKNQTIIISGESGAGKTVSARYIMR----YFASVQALIQSTDSNFHEAPQLTAVENEILATNPI------MEAFGNSKTSRNDNSSRFGKYIQILFDGNATIIGAK-----------------QTYLLERSRLVFQPNQERNYHIFYQILAGSSSEQKWKLVENSQEFNYLKQGNCSTIEGVNDKEEFKATVDALKTVGIDNDTCECIFS-----LLAALLHIGNIEVKHSRNDAYIDSKNENLINATSLLGVDPSSLVKWLTKRKIKMASEGILKPL------NEFQAVVARDSVAKFL-----YASLFNKALMYSAGVLIYG-----EHFKKNSF-EQFCINYANEKLQQEFYRHVFKLE---QEEYAAEGLNWSYIDYQDNQQCI-------------------SMIESRLGI----------------SLLDEECRMPTNSDENWVSKLNDAFSKPEFKNSYQKSRFG-NKEFTIKHYALDVVYCAEGDELLELFTNSDVPFVKDLVEQTAPPADTKKIKTKPKSNTLGSMFKSSLVSLMSTINETNAHYIRCIKPNEEKE.. 672
50 -10.600[L] KOG0479 DNA replication licensing factor, MCM3 component  ali follow..  14  208............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ELPESAPAGQLPRAVDCVADLDLADRVKRVRIIGVFRVLPNKQNGVSSGSFRSIIIINHIQMLSKEVIPNFEPQDVKDVRKISKRNPFELLARSLAPSI------GHEETKKALLCLLLGGMEKILNNGSRLRGDINVLLIGDPSVAKSQLLRYVLRMAPRAITTTRG----SSGVGLTAAVTTD--ERRLEAGAMVL-IDEFDKM-----SDIDRTAIHEVMEQGRVT---GIHAKLNACSVLAAAN-----------PGRYNPFK-IGMQDSLLSRFDLIFVLLDEHDADKDANVAE-TQGEADGTVLPMGGGVETISTINMETKKASSSIYEENTQWAGIQDTKILTMDFMRKYIRSVQPKLTDEASEVYADIRSFDITKTD 603
51 -10.400[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  13  1.....................................................................................................................................................................................................................................................................................................................................................................MVDKKTLGDVFKTVGLPPYTYVKPKHFGEVRADISQ--------------VGKHLLIEGPSGIGKTCVVFKVFEELQWSQRDFTYVGCRDQNAEQIIDDFLKNAAAGNALSPCVLVIDDFHLL------------SQAKRMEIGSTLKRLSDRAFEQAEPAK-------------------VILIGIPTAGVSLAYDLGPRL-GSYALTRASDVEIDKLISEGEQALAVLFE-----DRDVLLAESAGNF-----WLAQYVCNKVCAIEEVYETQDDAKILTFDILGIRGRLMAELTQRYLPIARTFAKGKRWRPGGILLALCKIQDSVVTFDQL--LKAVRTRISEVIFDPDHGTDLRKQIAFEADSGFSIEDP---TNLDSTLLFRDLGIEENTVE--DIGFSFAGEARRLVELVNAEMKAED---TFYDFLGKVYGESC----------RYYLVFLDEKDVMTNGKRIDHIV-----PIVIDDEGASVGISNTIGRIDLKDVWAQIQKAGKISTDDVNTIKNRCVVPMLEKI................................................................................. 517
52 -10.200[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  18  10...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GDEDFRPLAARMRPQ-------------TVEQYIGQQHILGP--KPLRRALEAGHI--------HSMILWGPPGTGKTTLAEVAANYANAEVERVSA-------VTSGVKEIRAAIEKARSGRRTILFVDEVHRFNKSQ--------------DAFLPHIE-----DGTVTFIGATNPSFELNNALL--SRARVYKLTSL--NQQEILQALHQAIADTE-KVAAVFADNVLDRLAELVNGD------------ARMSLNYLELLYDMAREDDQGRKQIDLPLLAEVAGEKVSRFDNKGDIWYDLISAVHKSIRG 269
53 -10.100[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  16  14...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLQDVVGQEHITKTLQNALV-------------KFSHAYLFSGPRGTGKTSAAKIIAKAINVDVMEIDAAS------NNGVDEIRDIRDHVK--APSVYIIDEVHMLTTG-------------AFNALLKTLE---EPPSHAIFILATTEPHKIPLTIIRCQRFDRMKEILTHEGIEAEDEALVLVARAAEMRDSLSLDQAISFADERVTVEDVLAITGAVSHEVLTQVVESAQKGETAEALQLVNQLLANGKDPLRFVEDLI-LERAQINDSFKTLAGEINDAS. 325
54 -10.100[R] COG1204 Superfamily II helicase  ali follow..  1363.................................................................................................................................................................................................................................................................................................................................................................................................KFFNKIQTQVFNSVYKTN------DSVFIGAPNGSGKTALLHHWSQEDYGTAVYIA-QEIVDRRYEEWYGKFSDLQDLKLIQVADLIFCSQWDSLSKRWRSMR-------SIQKVDFYICDELQLLGGFYGPLYEIVISRIRYMAVQLEKNIRVVGLSVS---------------------VANAR---DLGEWLGTSPQCIFNFSPKDRPNPLTIHLQSFSITHFPSLMLAMSKPIYRSLKNFISQRKST---VFTPDRKVAKQLAFDLVTFSMADEDEYLFSLMENEAFNKVEDAALQQSLKHGIAITSSNDQNIVQ---------YLYRHG------VLI-----ASRDV---IYSLKAKSNAVIVMGTQYYDGKEHRPISELLQMLGFT--ASI------GSSELS----------------QVILMTVTTKKE------YYKKFLNEPLPMESHLQVHDAFVSEISTQTIESKQDAVDWLTWSYMYRRLVANPAYYGLQDITHESVS-EFLSDLVETTMNDLSEARLITVDDEDDSCVALNLAMIAITYITMQTFALSLSERTKMKGLLEIVTSAAEYEQ... 1893
55 -10.000[R] COG1205 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster  ali follow..  15  30....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NGENNDNVSMLEQFLAQPETLLKGPYLSFRKSDLPLNFFPNLTLPFP-PHAHQARAFQRLGSDAPLVATG-TGSGKT--------EC---FM----P-LLNHCAGASQAGVKAII-------PMALATDQASRFAK-VGDSEIEPSKKMSAEKVITCKHT-LRESPPDILL---TN--KMLDYLLMRP---DQPLW------RYNQPGSLRYLV----------VDEL--HTFDGAQGSDLACLVRR-----LKHHIGVDNQRFACVGTS------ATVGDELGQLLDYAKTIFDQPFTDDAVIREDRYTAAE 308
56 -9.930[KL] COG0553 Superfamily II DNA/RNA helicases, SNF2 family  ali follow..  12  696................................................................................................................................................................................................................................................................................................................................................................................................QQIQATLRSYQTEGVHWLERLRKMHLNGILADDMGLGKTLVTQSKLEKGSGCSLIVCPTSLVYNWKEE-----------FRKFNPEFRTL--IDGVPSQRRKQLTALADRDVAITSYNLLQKDVELYKSDEAHHIKNRTTRNAKSVKMIQSDHRLILTGTPIE-DFLMPGLLDRFVGKYIRTGNYMGNKADNMVALKKKVS-------------ILRRMKEDVLKDLPPVSEILYHCHL------TESQKELYQSYAASAKQELSRLVKQEGFERIHIHVLATLTRLKQICCH----PAIFAKDAPEPGDSAKY-DMLMDLLS------SLVDSGHK----TVVFSQ--TKMLGIIKKDLESRGIPFVYLD---------GSTKNRLDLVFNEDPSLL---VFL-----ISLKAGGTG-------------LVGAD--------VIHYDMWWNPAVENQATDRVHRISRSVSS-LVTLNTIEEKILTLQNRKKSLVKKV-----DDEVVSKLTWEEVLELLQ................................................................... 1165
57 -9.870[J] KOG0066 eIF2-interacting protein ABC50 (ABC superfamily)  ali follow..  12  367..............................................................................................................................................................................................................................................................................................................................................................................................................FVNANLLIAHGRRYGLVGPNGHGKTTLLRHIATRAFAIPPNIDVLLCEQEVVATDKTAINTILEADVRRTEMLKKADELEKQFVAGDLTVQEESAEARARRILAGLGFSKEMQDRPTNKFSGGWRMRVSLARALYLEPTLLMLDEPTNHLDLLDNYLQG-WKKTLLIVSHD--------QSFLDNVCNEIIHLDQKKLQYYKGNYSMFKKMYVQKRREMKEYEKQEKRLRELKAHGQSKKAAEKKQKESLTRKQEKNKSKQQKQDEDEGPQELLARPKEYIVKFRFPELGVHNVTFAFPSQKPLFIKVDF----------GIDLTSRVAIVGPNGVGKSTFLKLLLGELHVGRFDQHSGEHLTAEESAAEY-LQRLFNLPHEKARKALGSFGLVSHAHTIKMKDLSGGQKARVLAELC--------SAPDVLIL-PTNNLDILAEAINE---YEGGVII-VSHDE----RLIRETGC--------TLYVIEDQTINEIVG---FDDYRKEVLDSLGEVVNNPSVVANAAVLQ........................................... 901
58 -9.830[R] COG0714 MoxR-like ATPases  ali follow..  15  5......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ISVLTQNLSQTIVGKDEAIRLVLVALLSGGHALLEDVPGVGKTLLAKSLARSINGKFQRVQGTNIWNPSSREFEFLPGPAFAN-------ILLADEINRATPR------TQAALLEVMEEKQVTVDGETRLVPHPFFVIATQNPIEYQGTFPLPDRFALSLSLGY-PSEAEELKMLQRQQNP-SCISLEEVEALQKAVRQVKLTEDLQQYLLRLVRAS--------TDEDVTLGVSPRGTTALQRATQAFAFLEERDYAIDDDVKFV............ 273
59 -9.650[LK] COG1197 Transcription-repair coupling factor (superfamily II helicase)  ali follow..  11  484...........................................................................................................................................................................................................................................................................................................................................................................................................................PVVHLDHGVGR----------GGLVTLDTG---------GIKAEYLLLNYANESK---LYVPVTSLHLISRYVGGSDESAP---------------LHKLGNEAWAKSRQKAAEKIRDVAAEL----LDVYAQREAKKGFAFKYDREEFQQFSATFPETYDQEMAINAVISDMCQPKAMDR-------------LVCGDVGFGKTEVAMRAAFLAVMNHKQVAVLVPTTLLAQQHYENFKDRFANLPVTAKEQKQILENLAEGKVD-IGTHKLSDVKFNDLGLL------IDEEHRFGVGQKEKIKQ-LRANIDIL---------TLTATPIPRTLNMAMNGIRDLSIISTFVRQDDLVVREAILREILRGGQVYYLEKLTALVPEARVIVGHGQMRERELERVMSDFTGIDVPTANTIII---ERADHFGLAQLRVGRSHHQAYA-MTKDAERRLDALENLD-NLGAGFILATHDLEIRGAGELLGNEQSGQIESIGFSLYMELLDAAVKALKEGREPSLEELTQQQADIELRVPALLPDDYLGDVNMRLSFYKRIAAAES 1037
60 -9.620[R] COG1483 Predicted ATPase (AAA+ superfamily)  ali follow..  10  18................................................................................................................................................................................................................................................................................................................................................................DSQVAPELGDVYTGEAPEIYRDPKEFFKRTYFTDATVEILKRILDTFEGKE-----RNIFLIYSLFGGGKTHLLLTLYHAFGYIAHSLGKYSIVEKNDKNLTVPDIETLRDLFKGERVLLLIDEIADYVDNLHNSGAEEDR-RYAGNVDNFIDRLSSALSNSTEEYNHSVVRALWDAVRRVGGADSYTPVRTVGINDELVEVLKKRI-----FKHVDPDIRRRTLERIRSETNDVEIFGHGGFAQEIP-RTYPFHPEYIQILRTIIEKTDLQRTRDMIRITRIVVRNL------DRYEKEGFAPAIILPIHIDLTNDRIRGMLFGEKSKFAYASIIDAELVNDEKYRRMILTYITYPFDAPTPLNDFPTLTT-RAIYDPKQWIPADIKDTVEEESHPHFVFLNRKD--GVFWFWRVANVTKMVDSKTEE------------------IQSNYGEIWNQLVRYVDQLVREEEHVRFFEQVIVSKEPQELMD---------NEMYKLFVLVSEDVDEKLLKGIVFQIGSGSRTYKNTVVVCYPIPGTMKHLIMTTAR--DMACQRVMDTVKEMYGKYGEDVVKI---QLNQLRDIRNRALEDLENQIVGSFRKV......... 698
61 -9.570[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  15  121............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TKHLFDNEGKSNQLARAVGQKLA---------APGEPSANPFFLYGGTGLGKTHLLHAIGNGINARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLD-ALLVDDIQFFAEK-----------EKTQEEFFHIFNSLFETGRQI-ILTSDRYPKEIEKIEER-SRFGWGLTTAIPPDLETRVAILKAEEHNMNLPEEV-AFFIAQRLRTNLEGA-LNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENEYYRIKVSDLKSKSRARSVTRPRQIAMALAKELT 406
62 -9.550[L] KOG0481 DNA replication licensing factor, MCM5 component  ali follow..  14  235......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EIPRHLQLFCDRSLCERVVPGNRVLIQGIYSIRKVGKPSRRDGREKAVVGVRAPYMRVVGITVDSEGAGAISRYSNITSDEEEHFRRMAAGDIYERLSQSLAPSI------GSRDIKKAITCMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAPIAYTSGKG----SSAAGLTASVMKD--NFVMEGGAMVL-IDEFDKM-----REDDRVAIHEAMEQQTIS---GITTTLNSCSVLAAAN-----------SGRWDDT--IDFMPTILSRFDMIFIVKDIHDESRDITLAK-------------------------IINVHLSSNKSAPSEPAEGEISLSTFKKYIHYCRTHCGPRLSEAAKSRYVLMRSGAGQQEK 597
63 -9.540[L] COG0470 ATPase involved in DNA replication  ali follow..  20  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................STSTEKRSKENLPWVEKYRPETLDEVYGQNEVITTVRKFVD-------------GKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLEL-----ASDDRGVRNQIKDFASTRQ-LIILDEADAMTNA-------------AQNALRRVIE--RYTKNTRFCVLANYAHKLTPALLSRCTRFR----------QPLPQEAIERRIANVLVHEKLKLSPNAEKALIELSNGDMRRVLN--VLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSA...... 269
64 -9.440[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  13  46...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KLNEIVGNEDTVSRLEVFAR-------------GNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLEL-----ASNDRGIDVVFAQQKVTLPKIIILDEADSMTDG-------------AQQALRRTME--IYSKTTRFALACNASDKIIEPIQSRCAVLRRLMNVIEKERVPYTDDGLEAIIFTAQMRQALNNLQSTFSGFGFINSENVFKVCDEPHPLLVKEMIQHCVNANIDEAYKILAHLWHLGYSPEDIIGNIFRVCKTFQMAEYLKLE........ 315
65 -9.410[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  10  54...........................................................................................................................................................................................................................................................................................................................................................................................................................LVLLGEPGVGKTHELEKLQRFTICEYSKVLGLNLRTFTNLKEDLFRDKTFSDLEGHYHLHLFLDSLDEG---------LLNVKSLAIGLVDEFKKPKYR---------------------SHINRLHLRLTCRTLAPSILEEALKALWEESYELAPLRRIDVINAVEAEGFSSDDFLKAINQRDIVPLAIK-----PISLGFLLNTYRRHNSQFPPEQKRYESYLEGCKCLCEEVSKCRHALKETGNLDIDQRLIVAARIRFAVWIDVEQGQVPAVPRQKLCFGYEESNGREFEIT-QEVIQEVLDTGLSRGLHRMGWAHQTYAEFFAAWYLTQR------NIDLSKIKTLLYSSADSTPKNVFQEIIKTDPDVLLQTDVANLLMQYEEEKKHSGLAEQLKVYICDSSKKEDTRRIAIDIAIECNLSELQGDLA--------KLTLCPSQPISIRVNAARAISSIGDQSTRLKLKSLALNVLPEDEQDELKALTAEELFQALTPSKRINLLGMHRYFLESELVPQLDSEDLVIALDWLKTQGVRCFGHPFEELGDAI..... 634
66 -9.340[L] COG1112 Superfamily I DNA and RNA helicases and helicase subunits  ali follow..  11  374................................................................................................................................................................................................................................................................................................................................................................................................SSQLKAYQSMLTKRLS------------IIQGPPGTGKSFVTLKAIETLLENTHSHVLPILV---ACQTNHAVDQILIRLLHQGASVMRLPEIAAVTIFQKAKHTKHSFKAAYNEIRHKKQRLIKQITNIMHNFNLEFVTLSYLHSKGIITTSQLESLRNNTEWISSVAENGEKTEEELISIWLGDAKVELITPSEITDGFEEELQIDPEKLEEIQKEAEDSGALMEEELRGKFINLRCKYLFSKLTTLHEKEIDTLLTIPNESAYAAAEKELNRLYRFYLKVDRERIGFSNKRLRGANVIGMTTTGLNKYRDILERINPKICFIEEAADVLEGPIIPAEQLVLIGRPNLSISMFERLVENDMEYTRLTMQ-PQI--------RRLVSSVYEDLSDYEITRFFLTEAQMLVQNNGVEPQKITCLTFYAAQKVATVDGYQGEENDVVLLSLNNDRTEVG--LSSPHRVCVSL-------SRARRGLFQLVAESNPLWWDA-INTLMNDETIQGLGDHLPLFTKD.................................................................. 978
67 -9.330[R] COG1855 ATPase (PilT family)  ali follow..  11  5.....................................................................................................................................................................................................................................................................................................................................................................................................................................RAITHASTGGWKEMKYVVDTSVVI----SGRVTEMLESGEIKGTIIVPEAVMLSEIEKLTKLAKDKGFEVIFAGERPKLEHIRLAKGGEIDNLIREVAAEFDAVLVTSDRVQHLVARAKGI------------------ETIYVRPRVVRPENTRIMSFFTPDTASVHLREGVPPYAKRGRIGDLKLVKLDDRPMSYEELNEIANEILEAARQDEDSSIEIERRGATVVQLRELRIAIAERPFADRME-----------VRPIAQVSIDEYGVSEELKRRIVE-----------------RQRGILISGPPGAGKSTFAASVALENGYIVKTMESPDEITQYA-PLEGDMSLTSDILLLVRPDYTIYDEL------RRTSDFQVFADMRLAGVGM------------IGVTHATRAVDAIQ-------RMIGRVELGMIPQVVDTVVFIDAIVKVYELSFTVKVADLARPV-EIYTYGEQVVVMPENLKAALEEKISKYVDDFEVEMVGRKAVIKVPEKHIPTLIGRKGRRI--KNIEDEFKISIDVIPKEV 531
68 -9.320[P] KOG0056 Heavy metal exporter HMT1, ABC superfamily  ali follow..  12  306............................................................................................................................................................................................................................................................................................................................................................................................................................................................GSMGLFNNLRTFLWIRVQQYTTREIEIELFRHLHQLSLRWHLQRKTGEVLRVMDRGTDSINNLLNYIVFSIAPTILDLLVAVAYFVYAFNWWFGLIVFLTMFLYIASTIAITEWRTKY-RMNLADNEQRARSVDSLLNFETVKYYGAEHYEVDCYREAILKYQKEEFLSMLTLNMLNTAQNIILCLGLLAGSLLCVYLVVHHQTLTVGDFVLFSTYLMELYMPLNWFEEEIVDAPGCSPLLGIEFSNVTFGYSPEKIVLRNVSFT----------VPAGKTVAIVGPSGAGKSTIMRLLFRDVQTGAILIDGQNI-NIEYAKLGASDEAVYEAARAAD--ILGFPEYETKVGERGLR--SGGEKQRVIARTLLK-------APIIVLL-ATS---ALDT------HTERNIQAALARVCANRTTII--VAHRLSTIIHADEILVLQQGSIAERGRHEELVLREDGIYAMWQQQLKNLDAEQSGGSDNGDASAESGSEKRRAGGAGGPSGTGTGGAHFRAGHAHGGAR.. 866
69 -9.280[D] COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins  ali follow..  15  340..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HKNAEKLRKTLESFGVKAHVGPAVTKYEV-NPHVGVKVSRIVNLADDLALALAAKDIRIEAPIPG--KSAIGIEVPNQEVAIVTLREVLDSPQAKADRNVLSVGLGR-------------DISG----EPVFAPLNKMP----------------LLVAGATGSGKSILLKAKPHEVKLMMIDPKMVELLKKVVAEMERRTRNIYNEMITRQPIVVIVDELADLM-----------VASGDVEDSIARLAQMARAA-GIHMILATQRPDVITGVIKAPSR----IAFGVSSQTDSRTILDTGGAEKLLGRGDMLYLPMGATKPTRVQGA----FLSDEEVETIVEFVVAQQKAQYAEEMTPTEETKVTEKVDDELYDDAVNLVIEMNSASVSMLQRRFR.... 747
70 -9.260[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  16  4...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PNILLTGTPGVGKTTLGKELASKSGLKYINVG--DLA------REEQLYDGYDEEYDCP----ILDEDRVVDELDNQMREGGVIVDYHGCDFFPE-----RWFHIVFVLRTD--TNVLYERLETRGYNEKKL------TDNIQCEIFQVLYEEATASYKEEIV------------HQLPSNKPEELENNVDQILKWIEQWIKDHNS............................................ 172
71 -9.140[J] COG0532 Translation initiation factor 2 (IF-2; GTPase)  ali follow..  12  361.....................................................................................................................................................................................................................................................................................................................................................................................................EYEVGMNVQDIAKSIKREPAKKLFMMGTMVNQNQSLIELILMDYGVTPVKKVEEDKSDIERLFVEDGYLK--ENMVERPAVVTIMGHVDLLDRFRESRVTEGEAGGITQHIGAYQIKA---------------------------NGKKITFLDT-----------------------PGHEA--------------------------TSMRARGASVTDITILVVAADDGVMPQTIEAINHSKAAGVPII---------------VAINKIDKPGA-QRVTQELTEH-------GVFPVAWDPENGSEDELLDTVLLVAEVQELKADPTVRAIGTVVEARLDQGKGAIATLLVQQGTLH----VQDPIV---VGNTYGRVRTMTRRIKEAGPSLTGLSDV----PQAGDH-----FEDEKAARAAGEERAKRAQLIKRQNTRRVNLDNLFDT--LKEGQT-KSVNIIIKADVQGSAEALAASLQKIE-VEGVKVD-IVHSAVGAISESDISAAASNAIIIGFNVRPTGLAREQAAQEEVDIRLHSIVIEEVETAMRGMLDPEFKEEIIGEAIVRETFNVSK. 864
72 -9.130[R] COG5545 Predicted P-loop ATPase and inactivated derivatives  ali follow..  12  361.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VEYLQSV----ERRYPNVDVSLLDKLA-ERYFGTNDMKRTLIAAV------ARAFEPGCKHDEITILQGKQKSLKSTFWEILA-----------GEEFFTDDLNGTEKDEVLKISQY------ILEYAEFENSYKKKD--------VSQLKAFLSRKKDSMEDFPRPSILVGTTNLDEFLDPT----G--------------ERRFWVIKVLFKKIPIK-QQERDLIWAAAVAAYRNGEQWRLTEVEWLDAANKQYQSTDTWEEAVMAWAELQKEVSVGELSDVLKIELAKQSKAEQNRVAAILRSHGWTRG 638
73 -9.100[L] KOG0482 DNA replication licensing factor, MCM7 component  ali follow..  13  239............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EHSDQVPVGHIPRSMTIMCRGEVTRMAQPGDHIVVSGVFLPLMRTGFAQMIQGLLSET-ICINKNDEISDKDAELTPEELEELADDFYERLATSLAPEI------GHLDVKKALL----------LLVGGVDKRPDGICLMGDPGVAKSQLLGYISRLAVRSYTTGRG----SSGVGLTAAVMKD--EMTLEGGALVL-IDEFDKM-----ADQDRTAIHEVMEQQTIS---GIMTTLNAVSILAAAN-----------PGRYNPRR-IQLPAALLSRFDLLWLIQDKPDRDND----------------------------LRLAKHITYVHSHSKQPPTRVKALDMNLMRRYINLCKRKNPTIPDELVGAYVELRREARNQKD 597

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.