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Query: [O] KOG0737 AAA+-type ATPase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEQKSVLFSALGVGVGLGIGLASGQSLGKWANGSISAEDGLTGEKIEQELVRQIVDGRESSVTFDEFPYYLSEKTRLLLTSAAYVHLKQSDISKHTRNLAPGSKAILLSGPADTEQVWMRQERTWTLRRHTSGNDLHSRGFDVTSQPPRLKRNASAASDMSSISSRSATSVSASSKRSANLCFDERLFLQSLYKVLVSISETNPIIIYLRDVEKLCQSERFYKLFQRLLTKLSGPVLVLGSRLLEPEDDCQEVGEGISALFPYNIEIRPPEDENQLMSWKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSAISYHLMNNKEPEYKNGRLVISSNSLSHGLNILQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGLPSVESREKILRTLLSKEKTENLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQECLKDQERRKREEAEKNSEEGSEAKEEVSEERGITLRPLSMEDMKVAKSQVAASFAAEGAGMNELKQWNDLYGEGGSRKKEQLSYFLLast
1 -174.000[O] KOG0737 AAA+-type ATPase  ali  100  1MEQKSVLFSALGVGVGLGIGLASGQSLGKWANGSISAEDGLTGEKIEQELVRQIVDGRESSVTFDEFPYYLSEKTRLLLTSAAYVHLKQSDISKHTRNLAPGSKAILLSGPADTEQVWMRQERTWTLRRHTSGNDLHSRGFDVTSQPPRLKRNASAASDMSSISSRSATSVSASSKRSANLCFDERLFLQSLYKVLVSISETNPIIIYLRDVEKLCQSERFYKLFQRLLTKLSGPVLVLGSRLLEPEDDCQEVGEGISALFPYNIEIRPPEDENQLMSWKTRFEDDMKVIQFQDNKNHIAEVLAANDLECDDLGSICHADTMFLSSHIEEIVVSAISYHLMNNKEPEYKNGRLVISSNSLSHGLNILQEGQGCFEDSLKLDTNIDSKEVAPDNEFEKRIRPEVIPANEIGVTFADIGSLDETKESLQELVMLPLRRPDLFKGGLLKPCRGILLFGPPGTGKTMMAKAIANEAGASFINVSMSTITSKWFGEDEKNVRALFTLAAKVSPTIIFVDEVDSMLGQRTRVGEHEAMRKIKNEFMTHWDGLMSNAGDRILVLAATNRPFDLDEAIIRRFERRIMVGLPSVESREKILRTLLSKEKTENLDFQELAQMTDGYSGSDLKNFCTTAAYRPVRELIKQECLKDQERRKREEAEKNSEEGSEAKEEVSEERGITLRPLSMEDMKVAKSQVAASFAAEGAGMNELKQWNDLYGEGGSRKKEQLSYFL 726
2 -93.000[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  18  104VKDTNVINKSITSLWSSPNLKEIDGEDEKKSVGQESITGSAKRKDRRSKTNGEANREPPSDISLSDIGGL--DDCINELLELVAMPIKHPEVYQYTG---HPPRGVLLHGPPGCGKTMLANALANELGVPFISISAPSIVSGMSGESE-----------------------------------------KKVREVFEEAKSLAPCLMFIDEIDAVTPKRRIVAQFLTCMDELSKPVLVIGA-----TNRPDSLDSALRRRFDREICLTVPSQDAREKILRTMAKG----LKLSGDFDFRQLAKQTPGYVGADLKALTAAAGIIAIKRIFNEISPLNKLDLNSDPRFNELDSDMALDSNDSLPLDHSSIIQRYLNAHPDPLSPEELEPLAICPQDFIEALSKREGFATVPGVSWNNIGALKSIRVELQMAIVQPIKRPELYQSVGISAPTGVLLWGPPGCGKTLLAKAVANESKANFISIRGPELLNKYVGESERAVRQVFLRARASSPCVIFFDELDAMVPRRDDSLS-EASSRVVNTLLTELDGLSDR--SGVYVIAATNRPDIIDPAMLRRLDKTLLVDLPDAHERVEILKTLTKQTPLEEVNLDVLGERCSNFSGADLAALVREAAVTALRSAVFADIASNEPEITQHSALEPIR-------------------VTNADFELAFKNIKPSV-----------SDRDRQKYQRLAKRSASTNDA 778
3 -88.500[O] KOG0730 AAA+-type ATPase  ali follow..  21  233.........................................................RLDEVGYDDVGGV--RKQMAQIRELVELPLRHPQLFKSIG---KPPKGILLYGPPGSGKTLIARAVANETGAFFFCINGPEIMSKLAGESE-----------------------------------------SNLRKAFEEAEKNAPSIIFIDEIDSIAPKRRIVSQLLTLMDGLKSHVIVMGA-----TNRPNSIDPALRRRFDREIDIGVPDEIGRLEVLRIHTKN----MKLAEDVDLERISKDTHGYVGADLAALCTEAALQCIRE-----------------------------------KMDVIDLEDDSIDAEILNSMAVSNEHFHTALGNSNPSALRETVVEVPNVSWEDIGGLENVKRELQETVQYPVEHPEKFEKFGMSPSKGVLFYGPPGCGKTLLAKAIANECQANFISVKGPELLTMWFGESEANVREIFDKARQSAPCVLFFDELDSIATQRGNSAGDGAADRVLNQLLTEMDGMNAK--KTVFIIGATNRPDIIDSALLRRLDQLIYIPLPDEDSRLNIFKACLRKSPVKDVDVTALAKYTQGFSGADITEICQRACKYAIRENIEKDIENERRRSQNPEAMEEDMVDDEVSE------------IRAAHFEESMKYARRSV-----------SDADIRKYQAFAQTQSRGFGS 807
4 -87.500[O] COG0464 ATPases of the AAA+ class  ali follow..  22  196............................................ELLPEAMEIISEQNIPTVMYEDLGGL--KDAISKVREMIELPLKHPELFDRLG---DAPKGVLLQGPPGTGKTMLAKAVANESDAYFISINGPEIMSKYYGESE-----------------------------------------RAIREIFEDAEKNAPAIIFLDEIDSIAPKRRVVAQLLSLMDGLKANVIVIGA-----TNRPEALDIALRRRFDREIELRVPDTEGRLEIFQIHTRG----MPLADNVNLMDFAQITYGFVGADIAALCREAAMSALRRI-----------------------------------LPKINLNEPEISKEILDALQVTREDFENALKDVQPSAIREILIEVPNVSWEDVGGLERVKELLKEVVEWPLKNPESYRDIGVEAPKGVLLYGPPGTGKTLLAKAIAHESDANFITAKGSDLLSKWYGESEKRIAEVFTRARQVAPSIIFLDELDSLAPIRGTSVEPQVTARILNQLLSEMDGLEELRA--VVVIGATNRPDIIDPALLRRFDELILVPVPDEGARREIFRVHTKNMALEDVDIEKLVSFTDQYTGADIAAVCKKAGRHALREDLHAKK------------------------------------VRQKHFLQAIEETGPSV-----------TPDTMKYYEAIKGEKRKSKEI 758
5 -85.300[O] KOG0739 AAA+-type ATPase  ali follow..  33  83................................................................................................................................................................................................................................................................................................................................................................................KPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVM-EKPNIRWNDVAGLEGAKEALKEAVILPIKFPHLFTG-KRTPWRGILLFGPPGTGKSYLAKAVATEANSTFFSVSSSDLMSKWLGESEKLVKNLFELARQHKPSIIFIDEVDSLCGSRNE-NESEAARRIKTEFLVQMQGVGNN-NDGTLVLGATNIPWVLDSAIRRRFEKRIYIPLPEEAARAQMFRLHLGSTPLTDANIHELARKTEGYSGADISIIVRDSLMQPVRKVQSATHFKKVCGPSRTNCSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNAD--DLLKVKKFSEDFGQES........... 437
6 -77.300[O] KOG0740 AAA+-type ATPase  ali follow..  36  356...............................................................................................................................................................................................................................................................................................................................................................................MQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHG-PPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTG-LRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGD-GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQLSEEEIEQIVQQSDAFSGADMTQLCRGASLGPIRSLQTA--------------------------DIATITPDQVRPIAYIDFENAFRTVRPSVSPK--DLELYENWNKTFGCGK........... 674
7 -76.100[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  22  375............................................................YRSKVPMPLQ--EETVNILASVLSPPLCPSALA------SKLRVAVLLHGIPGCGKRTVVKYVARRLGLHVVEFSCHSLLASSERKTS-----------------------------------------TALAQTFNMARRYSPTILLLRHFDVFKNLGEIASVIRELTEPVSNQVLLIAS-----AESTEGISPTIRRCFSHEIRMGSLNDEQRSEMLSQSLQGVSQFLNISSDEFMKGLVGQTSGFLPRDLQALVADAGANLYISQESETK----------------------KINSLSDDLHGVDIHQASQIDNSTEKLTAKEDFTKALDRSKKRNASALGAPKVPNVKWDDVGGLEDVKTSILDTVQLPLLHKDLFSSGL-RKRSGVLLYGPPGTGKTLLAKAVATECSLNFLSVKGPELINMYIGESEKNVRDIFEKARSARPCVIFFDELDSLAPARGASGDSGVMDRVVSQMLAEIDGL-SDSSQDLFIIGASNRPDLIDPALLRRFDKLLYVGVADASYRERVLKALTRKFKLEDVSLYSVAKKCSTFTGADMYALCADAWFQAAKRKVSK---------------------SDSGDMPTEEDDPDSVVVEYVDFIKAMDQLSPSLS-----------ITELKKYEMLRDQ....... 967
8 -69.800[O] KOG0741 AAA+-type ATPase  ali follow..  12  208......................................................IINPDWNFEKMGIGG-LDKEFSDIFRRAFAFRVFPPEIVEQMG---IHVKGILLYGPPGCGKTLLARQIGKMLNAREPKV-------------------------------------VNGPEILNKYVGESEANIRKLFADAEEEQRSGLHIIIFDEIDAICKQRTVVNQLLSKIDGVENNILVIGM-----TNRPDLIDEALLRRLEVKMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRHIK-------------------------------------ASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDGELLVQQTKNSD---RTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKQAMKKIFDDAYKSQLSCVVVDDIERLLDYVPIGP--RFSNLVLQALLVLLKKAPPQ-GRKLLIIGTTSRKDVLQEMEMLAFSTTIHV--PNIATGEQLLEALELLGNLKDKERTTIAQQVKGKKGIKKLLMLIEMSLQMDPE------------------------------------------YRVRKFLALLREEGASPLDF............................. 743
9 -69.000[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  23  2.....................................................................................................................................................................................................................................................SLEELEAMDQSNPGEFLERVREKIRMLNSETRILQSRVNTSTKNASIAENMERIRLNKQLPYLVGNVVEVLDEHSGVVNASTRMSSY---------------------------LPITGLIPNSELRPGDLVALHKDTNIVFEKLPPDYDMKVGGMVLKSDAKPDETYEDIGGLERQIEELNEAIVLSLTHPERFEKLNIKPPKGVLMYGPPGTGKTLMARACASKTNATFLKLAGPQLVQMYIGDGARLVRDAFALAKERKPTIIFIDEIDAIGAKRSDSTGDREVQRTMLELLNQLDGFSSS--EEVKIIAATNRVDILDPALLRRLDRKIEFPLPNTLGRKRILQIHARKMSVDDVNFDELARSTEGFNGAQCKAVCVEAGMAALRK--------------------------------------EKTEISQNDFMDGIQEVLSRKKSK............................. 396
10 -68.600[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  23  28......................................................................................................................................................................................................................................................................EELQLVVAEKHQNLRRLQ--AQRNELNAKVRMLREELQLLQEQGSYVGEVVKPMDKKKVLVKVHPEGKFVV-----------------------------DLDKNIDINDVTPNCRVALRNESYTLHKILPNKVDPLVSLMMVEKVPDSTYEMVGGLDKQIKEIKEVIELPVKHPELFDALGIAQPKGVLLYGPPGTGKTLLARAVAHHTECTFIRVSGSELVQKFIGEGSRMVRELFVMAREHAPSIIFMDEIDSIGSSRSGSGGDSEVQRTMLELLNQLDGFEAT--KNIKVIMATNRIDILDPALLRRIDRKIEFPPPNEEARLDILKIHSRKMNLRGINLRKIAELMPGASGAEVKGVCTEAGMYALRE--------------------------------------RRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK.................... 405
11 -67.500[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  32  164.........................................................................................................................................................................................................................................................................................................................................................................................................DDTDPMVTVMKLEKAPQETYADIGGLDTQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAVGTKRSNSGGEREIQRTMLELLNQLDGFDSRGD--VKVIMATNRIETLDPALIRRIDRKIEFPLPDEKTKRRIFTIHTSRMTLEDVNLSELIMAKDDLSGADIKAICTEAGLMALRE--------------------------------------RRMKVTNEDFKKSKESVLYRKKEGT............................ 433
12 -66.900[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  32  148......................................................................................................................................................................................................................................................................................................................................................................................................................EKPDVSYNDIGGCDIQKQEIREAVELPLTHHELYKQIGIDPPRGVLLYGPPGTGKTMLAKAVANHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEVDAIATARAQTGADREVQRILMELLNQMDGFDQTVN--VKVIMATNRADTLDPALLRRLDRKIEFPLPDRRQKRLVFQVCTSKMNLDEVDLEDYVSRPDKISAAEIAAICQEAGMHAVRK--------------------------------------NRYVILPKDFEKGYRANVKKPDTD............................. 403
13 -66.700[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  25  1...........................................................................................................................................................................................................................................MLLLQFSNMVEPTGPAIVEDERTKAECRDIEQKLKDLRKKESEMTKQFDK---------SENDIKSLQSVGQIVGEVLKQLSEEKFIVKATNGPRYVV-----------------------------GCRRSINKEELKQGTRVSLDMTTLTIMRQLPREVDPLVYKMSHEDPGNISYSDVGGLAEQIRELREVVELPLINPELFKRVGITPPKGCLLFGPPGTGKTLLARAVASQLDCNFLKVVSSAIVDKYIGESARMIREMFNYARDHQPCIVFMDEIDAIGGRREGTSADREIQRTLMELLNQLDGFDSLGK--VKVIMATNRPDTLDPALLRRLDRKIEIGLPNEQSRLEILKIHSNKITKGEIDFEAVVKLSDGFSAADLRNVCTEAGMFAIRA--------------------------------------EREFVIDEDFMKAVRKVGDAKRLETKLDYK....................... 404
14 -66.700[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  32  157...............................................................................................................................................................................................................................................................................................................................................................................................................VKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKERFEKLGVRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFQLAKEKAPCIIFIDEIDAIGTKRFDSSGDREVQRTMLELLNQLDGFSSD--ERIKVIAATNRADILDPALMRRLDRKIEFPHPTEEARARILQIHSRKMNVPDVNFEELARSTDDFNGAQLKAVCVEAGMLALRR--------------------------------------DATEVNHEDFNEGIIQVQAKKKAS............................. 419
15 -66.000[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  24  13..................................................................................................................................................................................................................................................................KEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARDGAGGDNEVQRTMLELINQLDGFDPRGN--IKVLMATNRPDTLDPALMRRLDRKIEFSLPDLEGRTHIFKIHARSMSVEDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRA--------------------------------------RRKIATEKDFLEAVNKVIKSYAKFSATPR........................ 428
16 -61.500[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  30  88............................................................................................................................................................................................................................................................................................................................................................................................................ESDPRVIETEIVRDITLDDVVGQEEAKRKAKVILEY-LRNPEKFGKWA---PKNVLFYGPPGTGKTMMAKALSNEAKTPFLSVKSTKLIGEHVGDGARRVHELYERARQLAPCIVFLDEFDAIALDRGYQEIRGDVSEIVNALLTELDGTNSNEG--ICTIAATNRVELLDASIRSRFEEEIEFRLPSYEERLEILRRNLEEFPVVKARLELVAAASEGFSGRDLVEKVIKASLHKAIA-------------------------------------EGKDKIETEDLLTAAEKVKMPSRQPPKQMF........................ 351
17 -51.900[O] COG0465 ATP-dependent Zn proteases  ali follow..  37  139................................................................................................................................................................................................................................................................................................................................................................................................................ARMLTEDQIKTSFADVAGCDEAKEEVSELVDY-LREPSRFQKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVGVGASRVRDMFEQAKKAAPCIIFIDEIDAVGRQRGAGGGHDEREQTLNQMLVEMDGFEGNEG--IIVIAATNRPDVLDPALLRRFDRQVVVGLPDVRGREQILKVHMRRVPLTDIDASVIARGTPGFSGADLANLVNEAALFAARG--------------------------------------NKRVVSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYHEAG........... 417
18 -46.000[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  31  300.........................................................................................................................................................................................................................................................................................................................................................................................................NIGKATITRADKHSKNKIYFKDVAGCDEAKQEIMEFVHF-LKNPKKYEDLGAKIPKGALLVGPPGTGKTLLAKATAGESGVPFLSISGSDFMEMFVGVGPSRVRHLFQEARQAAPSIIFIDEIDAIGRARGRGGGNDERESTLNQLLVEMDGFGTTAG--VVVLAGTNRPDILDKALLRRFDRQITIDKPDIKGRDQIFKIYLKKIKLDSYYSQRLAALTPGFAGADIANVCNEAALIAARH--------------------------------------EGATVTMAHFESAIDRVIGGLEKKNRVISKLERRTVAYHESG........... 587
19 -45.700[O] KOG0734 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  32  269................................................................................................................................................................................................................................................................................................................................................................................................................SAVDPVQMKNVTFEHVKGVEEAKQELQEVVEF-LKNPQKFTILGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEG--VIIIGATNFPEALDNALIRRFDMQVTVPRPDVKGRTEILKWYLNKIKFQSVDPEIIARGTVGFSGAELENLVNQAALKAAVD--------------------------------------GKEMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESG........... 545
20 -35.300[O] KOG0743 AAA+-type ATPase  ali follow..  13  207..............................................................TFDTL--AMDPNAKKKIIDDLERFLKRKEFYKRVG-----KRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSIYDN-----------------------------------------------GELKRVLLSTTNRS--ILVIEDIDCNAEVRDTLSGILNFIDGLDERIIVF------TTNHKERLDPALLRRMDVHINMSYCTGLGFRTLVSNYLGLDGLNHPLCEEI---EALVDSTEVTPAELAEMQDDDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQSLTGFLMLFRSLFNDEVPEREHPSTFETLAMDPGAKKKIIDDMERFLKRREFYKRVGKAWKRGYLLYGPPGTGKSSLIAAMANYLKFDVFDLELSSIYE------NAQLKSILLSTTN---SILVIEDIDCSSAEVVDREADEYQEYTLSGLLNFVDGLWSSFGDERIIVFTTNHKERLDPALLRRMDMHINMSYCTGLGFRTLVSNYLGLGGLNHPLCEEIEALIDSVTPAELAEELMDVVLRGVVSFVENRKVEISKTKELEGSTCRKLDGDDKHNVSSTNDLKK.................................................... 981
21 -31.000[K] COG1224 DNA helicase TIP49, TBP-interacting protein  ali follow..  16  27.......................................................................................................................................................................................................................................................................................................................................................................................................................DENLRAKDVADGLVGQKRAREAAGVI---VRLIKSG-KMAGRGILMAGPPGTGKTAIAVAISKELGIPFVQVSASEFYSAEMKKTEALIQAMRKAVRIRETRTVLEGEVVGLDYNMVPNPYNPTQKIPESATLTLATKDEKRSVGGRLAMQFFTQGIEVGDVIVIDKETGRIGKLGRSEKAKKKYDLGDDEVPVPSGKVEKEKEFTYVVTLHDLDEANARRTSI---FSLFSPPSREIDNEVREAVDEQVKRLVEEGRAELVPGVLFIDETHLMDIE.......................................... 303
22 -26.500[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  14  55..........................................................................................................................................................................................................................................................................................................................................................................................................................FPLVRLAGVGRQTELLVRNT-------EQFIVG--RPANNVLMSGARGTGKSSLVKALLHEYADKGLR-----LIEVDKSDLIGLPYLLTLLKECPEKFIVFCDDLSTALDGGLSQRCANVLVYATSNRRHLMPEYFDENAGTTGMRGEIHQKEAVEEKISLRFGLWLSFYPFDQNDYLAAVQNWLEDFGVPQMAALQWAQTRGSRSGRSAWQFACDWAGRLPKQ........................................................................................... 284
23 -20.100[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  18  27...........................................................................................................................................................................................................................................................................................................................................................................................................................LLTEYVGQPHVREQMEIFIQAAKQRGDALDH--------VLIFGPPGLGKTTLANIIANEMGVNLRTTSGPVL--------EKAGDLAAMLTNLEPHDVLFIDEI------------HRLSPVVEEILYPAME-SIKLDLPPFTLIGATTRAGSLTSPLRDRFGIVQRLEFYQVADLEHIVSRSAKCLELTPEGAHQLARRSRGTPRITNRLL...................................................................................................... 227
24 -16.900[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  13  159..............................................................ALEKYTIDLTARAESGKLDPVI---RDEEIRRAIQVLQRRTKN-VLIGEPGVGKTAIVEGLAQRINKRVLSLDMGALIAG------------------------------------AKYRGEFEERLKAVLNELSKEE--GRVILFIDEIHTMVGAMDAGNLLKPSLAR--GELHCVGATTLDEYRQYIEKDAALERRF-QKVFVGEPTVEDTIAILRGLKEEIHHHVQITDPAIVAAATLSHRYVSDRQLKAIDLIDEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAEEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSRATGIPRMEEELHKRVIGQHEAIEAVSNAIRRSRAGLLFLGPTGVGKTELCKTLANDDENAMVRIDMSEFMEKYVGYEE----GYLTEAVRRRPSVILLDEVE------------KAHHDVFNILLQVLDGRLTDGQGRTVVIMTSNLGSHFRPEFINRIDETVVFHPLGKENIREIATIQLARLHFTDACLDFIGEVDPVYGARPLKRAIQQEIENPLAQQI......................................................................................... 831
25 -15.600[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  24  111...........................................................................................................................................................................................................................................................................................................................................................................................................................TLDDVVGQDHLLSLLRSAVE-------------SNRLPSIVFWGPPGTGKTSIAKSLINSSKDPFVSLSAVT-------SGVKDVRDAVESAKRLKRTVLFMDEV------------HRFNKSQQDTFLPVIE------DGSILFIGATNPSFHLITPLLSRC-RVLTLNPLKPNHVETLLRRAVDDSEVDDSVIEFLANNCDGDARVALNAL...................................................................................................... 306
26 -15.600[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  16  172.........................................................................................................................................................................................................................................................................................................................................................................................................AKQTQLRLEELNQEAWSRDSVEIIGNSGPMLAMKADI-----------DVVAPSQFNILIHGETGVGKELVARTISNRKRQPLVYVNCAAIPENLL-ESE-HVKGAFTGADRARM-TLFLDEIG------------ELPLSAQSKILRALQGQDRVQTVDVRILAATNR--DLKKEVEARFRADLYIYVPPLRERKGDLSLLAGGITQLKLHGDVLSQLIQPWPGNELEHVINRAALKAKARQRGEDLGELQGPRAAMVEPTAQDEPMLGEWIGELGLRDATDEFQRHLISETLTQADFNWAEAARRL......................... 502
27 -15.500[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  12  332................................................................................................................................................................................................................TKDLQEMMDEIDVSKRLKIALLLIQKEKAVA------------KLKYDINKDVEKKV-----QDHHRKYLLNEQLKVIKKELGIEKDEKTTIIEKIDERIKTLAVPEYALKVINEEKTKLQFLDPHSSEFSVTRNYLEWLTS--------------------------------------LTSPENRRLSVAKKALD--------EGHYGMKDVKERIMEFIAVNLLRKSI---------GGLCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMTDVYVGAMPGKMIQCMKKVKTENP-LVLIDEVDKIGGAGFHGDPASA-------LLELLDPEQNAN-SRVLFICTANEISKIPGPLRDRME---MIDVSGAEEKVEIAHQHLIPQLRKDTSLATLEELIKHYSGQHIERIFRKAALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIV-VCTENLQKFVGR-DRMYEVTPPGVIMGLAWTAMGGS............. 801
28 -15.500[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  17  180.........................................................................................................................................................................................................................................................................................................................................................................................................................DFLKSGIATRNPHFNRMIEQI----------EKVAIKSRAPILLNGPTGAGKSFLARRIRHQFSGAFVEVNCATLRGDTA-MST-HVKGAFTGARESRE-MLFLDEIG------------ELGADEQAMLLKAIEGSDRQVSSDFQLIAGTVR--DLRQLVAEKFREDLYFTLPGLRQRQEDIEPNLDYERHASLTGDSVRFNTEAWRGNELSASVTRMATFATSGRITLDVVEDEINRLRYNWQESRPSALTALLGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQLF......................... 495
29 -15.300[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  16  263......................................................................................................................................................................................................................................................................................................................................................................................................................APDEPHIEQLVGECRVMRQLKRLI-----------SRIAPSPSSVMVVGESGTGKEVVARAISGRRNKPFIAINCAAIPEQFTGASANGKTGLIQAANT----TLFLDEIG------------DMPLMLQAKLLRAIEGASSPIQVDIRIISATNQ--NLAQFIAEGKFREIPITLPPLRERQEDIELLVHGSVYPGIAPDVVEILRKRWPGNELSNLMEYLVVVPSGEVIDSTLLPPNLLNNGTTEQSDVTEVTEAHLSLDDAGGTALEEMEKQMIREALSR..................................... 562
30 -15.300[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  17  179...........................................................................................................................................................................................................................................................................................................................................................................................................................QLDPVIGREDEIRRTIRVLS-------------RRTKNNPVLIGEPGVGKTSIAEGLARRSNCKLLSLDVGSLVSKFRGEFEERIKSVLEVEESETPIILFVDEMHLLMGASGGEGGMDAANLLKPML----------ARGKLHCIGATTKYIEKDAAFERRF-QIILVKEPSIEDTISILRGLKEKYEISDRALVTAAHLASRYLTSDSAIDLVDEAAAAVRVTRESQPEVLDNLERKLRQLRVEIRALEREKDEASKERLKAARKEAEQVEEETRPIREKYELEKSRGSELQDAKRRLDELKAKAEDA..... 493
31 -15.200[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  12  3...........................................................................................................................................................................................................................................................................................................................................................................................................DKKTLGDVFKTVGPPYTYVKPKHFGEVRADISQ------------------VGKHLLIEGPSGIGKTCVVFKVFEELQWSQRDFTYVGCRDQNAEQIIDDFLKNAAAGNALSPCVLVIDDFHLL--------SQAKRMEIGSTLKRLSDAFEQAEPAKVILIGIPTAGVSLAYDLGPRL-GSYALTRASDVEIDKLISEGEQALAVLFEDRDVLLAESAGNFW--AQYVCNKVCAIE.............................................................................................. 217
32 -15.200[R] COG0714 MoxR-like ATPases  ali follow..  20  5..................................................................................................................................................................................................................................................................................................................................................................................................................................ISVLTQNLSQTIV----KDEAIRLVLVALLSGALLEDVPGVGKTLLAKSLARSINGKF-DITGTNIWNPSSREFEFLPGPAFA-------NILLADEIN-----RATPRTQAALLEVMEEKQVTVDGETRLVPHPFFVI-ATQNPIELPEAQLDRFALSLSLGYPSEAEELKMLQRQQNPEAIAVGDLESCI------SLEEVEALQKAVRQVKLTEDLQQ....................................................................................... 222
33 -15.100[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  16  312...........................................................................................................................................................................................................................................................................................................................................................................................................HSKVRAPLVSREQIPPALRRLGGDAPVIAALQAKA-----------AKLARTRLPILIQGETGTGKEHLARAIGSGLEGPFVAINCAAIPEQLI-ESE-YLPGAFTGASAADGGTLFLDEIG------------DMPLALQSRLLRVLAGGTAPRKVRIRIVSASHR--PLQTLVSQGAFREATLTLPALRDRPDVLEQLLKRHGDGELILSPAA-KAHDWPGNELDNVIGVAAALAENGVVELGDLPDQLLANADTVGGNEASAT-TACNWNISEAARRLGLDRSTVHRQIKRYRLKPHRH............................. 627
34 -15.000[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  14  197......................................................................................................................................................................................................................................................................................................................................................................................................................TQDLSAFSQIIAVSAKMKHVVEQA-----------RKLAMLSAPLLITGDTGTGKDLFAYACSPRSAKPYLALNCASI-SELFGHAPEGKKGFFEQANG----SVLLDEIG------------EMSPRMQAKLLRFLNGEDHEIHVDVRVICATQK--NLVELVQKGLFRELTLNLPPLRDCPQDIMPLTEGVPRPKLSADLSTVLTRGWPGNQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQL-----YRSYPSTRKLAKRLGVSHTAIANKLREYGLSQKKGEE...... 513
35 -14.900[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  23  25...........................................................................................................................................................................................................................................................................................................................................................................................................................TVEQYIGQQHILKPLRRALE-------------AGHIHSMILWGPPGTGKTTLAEVAANYANAEVERVSAVT-------SGVKEIRAAIEKARENRRTILFVDEV------------HRFNKSQQDAFLPHIE------DGTVTFIGATNPSFELNNALLSRA-RVYKLTSLNQQEILQALHQAIADTEFADNVLDRLAELVNGDARMSLNYL...................................................................................................... 216
36 -14.900[L] COG0470 ATPase involved in DNA replication  ali follow..  17  23...........................................................................................................................................................................................................................................................................................................................................................................................................................TLDEVYGQNEVITTVRKFVD--------------GKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMVLEL-----ASDDRGIDVVRNQIKDFASTLIILDEADAM-----TNAAQNALRRVIERY-----------TKNTRFCVLANYAHKLTPALLSRCTRFRFQPLPQEAIERRIANVL-EKLKLSPNAEKALIELSNG----DMRR-----VLNVLQSCKATLDNPDEDEISDDVIYECCGAPRPSDLKAV------LKSILEDDWGTAHYTLNKVRSAKGLALIDLIE.................... 279
37 -14.900[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  16  49...........................................................................................................................................................................................................................................................................................................................................................................................................................SLDDVAAHRDIIDTIDRLTNLP-----------------LLLYGPPGTGKTSTILAVARKLRNMILELNASD--DRGIDVVRQQIQD-FASTQSFSLGLVLLDEADAM-----TKDAQFALRRVIEKY-----------TKSTRFALIGNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKHVI-ERLVVSDCGLAALVRLSNG----DMRK-----ALNILQSTHMASKEITEEESKQITEEDVYLCTGNPLPKDIEQ----SHWLLNKPFDECYKDVSEIKTRKGLAIVDIVK.................... 310
38 -14.500[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  11 1122........................................KDKLAVQEVIEKVMKVKIDTDGIYNLDSMEIFQDMSLKEGPLSKVVWTRPRLFCLVWRCLLAKEPVLLVGDTGCGKTTVCQILAECLHKELHIINAHTENGDIIGAQRPVRNRSAVNYSLHSQLCEKFNVQESLDSIDDLIEKFEKLSSSEKNDNLSNLIERGALVFLLDEIS--LADDSVLERLNSVLELSRTLTLFFATMNPGGDYGKKELSPALRNRFTEIWVPPMVDTEDILKIVEGKLHNELARPLVEYAKWHANEYLYTDVISIRDVLSAVEFINACEILDLNLVLFNAVSMVFIDALGSFTTFSLSNNLASLHAERQRCFAKLNELAGSNIMASKSADISIKFSDSSFF-----GIPLGDSVESDSTYSLHTDTTLMNASKVL------------RALQVLKPILLEGSPGVGKTSLITALARETGHQLVRINLSDQTDAWRAPFLAAMRVLLDELNLASQSVL--EGLNACLDHRNEAYIPELDKVFKAH-----------PNFRVFA---AQNP-GLPRSFINRF-SVVYVEALKEKDMIEIAACNYHQVNEDWRLIKFMFRLQDNIEKDISFGSFGSPWEFNLRDTLRWLQLLNDAPKYTCVSPADYLEVMVLHRMRTVEDRVRTCELFKEVFDIDYEPRTIGFSLSSQCFK........................ 1829
39 -14.200[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  15  329...............................................................................................................................................................................................................................................................................................................................................................................AQQKKEQEEKKILETVARMDDSNKKESQPSQIWTSKYAPT----SLKDICGNKGVVQKLQKWL-----HKNRKSNFNKPGPKAVLLSGPPGIGKTTAAHLVAKLEGYDVLELNASDTRSK-----DEQLFGVTDSQSAKSRLVLIMDEIDGM-----SSGDRGGVGQLNM--------IIKKSMIPIICI--CNDRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMSIAYREKLSPQAVDQLVQGTQS----DMRQIINLLSTYKLSC........................................................................................... 591
40 -14.200[O] COG0466 ATP-dependent Lon protease, bacterial type  ali follow..  17  324.............................................................................................................................................................................................................................................................................................................................................................................................................................SNHNGLEKVKERIIQHLAVMKLKKEK---------QGLLLTGPPGTGKTSLGKSIADALGREYVRISLGGVRDEYIGALPGRIIQGMRKAGTKNP-VFILDEVDKLSTSYAGD-DPEQNNTFSDHYLVPYD-------SEVFFIATANSLASIPWPLLDRME--IEISGYTKNEKLAIAKDHLLPCILEEHGLDA-LKIEDEALKGIIDKYTREAGVRGLKKQLAR....................................................................................... 553
41 -14.100[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  12  32..................................................................................................................................................................................................................................................................................................................................................................................................QRRLVQDEVRDNLTRKLRSGEEL---FPGVVGYDDTVIPQLVNALLA----------------NFILLGLRGQAKSRILRAITEADRYVEKLATPDVTVADLIGDPIKAARLGTSLGDTRS--IFAVNELADLSPK------QVALFNILQEGDVQIKGYPIRLELDVMLVFSAN-PEDIVTPLKDRIGSEIRTHYPDVQLGMDITAQEAEGVVVPPFIAELIEDIAFQAREDGRIDKLSGVS---QRLPISLMELACANAERRSLVSGDAPVVRVTDVYAGLPAITGKMELEYEGELKGADNVAKDLIRKA............................ 383
42 -14.100[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  13  211........................................................................................................................................................................................................................................................................................................................................................................................................................TRYVLGDMLGQSPQMEQVRQTIL-----------LYARSSAAVLIEGETGTGKELAAQAIQGKKSHPFVAVNCGAIAESFTGSRRGGRAGLFEIAHG----TLFLDEIG------------EMPLPLQTRLLRVLEGGHQPVPVDVRVISATHC--NLEEDMRQGQFRRLRLQLPPLRERVADILPLAESKVSLAALSAPFSAALRQGLQASETVLVHYDWPGNIRE-LRNMMERLALFLSVEPTPDLTPQFLQLLLPELARESAKIPAPRLLTPQQALEKFNGDKTAAANYL......................... 515
43 -14.000[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  17  46...........................................................................................................................................................................................................................................................................................................................................................................................................................KLNEIVGNEDTVSRLEVFAR--------------GNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAMLEL-----ASNDRGIDVVRNKIKMFAQQIIILDEADSM-----TDGAQQALRRTMEIY-----------SKTTRFALACNASDKIIEPIQSRCAVLRYTKLTDAQILTRLMNVI-ERVPYTDDGLEAIIFTAQGDMRQALNNLQSTFS................................................................................................. 241
44 -14.000[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali follow..  13  124.............................................................................................................................................................................................................................................................................................................................................................................................................................STILCREDEQIRIFEFVKGCIDQ---------QKAGSLYICGCPGTGKSLSMEKVVQQVPVDTLSVNCTSLSK-----TTDIFSKILGESSSSRMMLIIADEMDYLITKDR-------------GVLYDLFMLTTLPFSRCILIGVANA--DLADRFLPKLPMVITFRAYSKDQILRILQERLRYVAFQPKALELCARKVAAASG-DMRCVCRSAL-----EILEIETRGSTGPESQGPTPDDSV-------------------VRMDHMAAALSKTFKSPVVETIQSLPQHQ.................... 411
45 -13.800[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  19  79...............................................................................................................................................................................................................................................................................................................................................................................................................................VIGQERAKKVLAVAVYNHYKRLN--KDDIELGKSNILMIGPTGSGKTLLAETLARLLNVPFTIADATTLTEAYVGEDENIIQKLLQKCEKAQMGIVYIDEIDKISRKSDSITRDVSGEGVQQALLKLIEGLQVDTRNILFICGGA----GLERVIQNRSARG----IPEFVGRLPVIATL---DELDEAALMQILTEPKNFRPDALKAVARKAGARGLRSILEG....................................................................................... 378
46 -13.800[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  15  394.............................................................................................................................................................................................................................................................................................................................................................................................................................KSLPCRSKEMEEITAFIKGSISDDQ-------CLGRCMYIHGVPGTGKTISVLSVMKNLPYCFVEINGSVIYEGLSGHRNERFAEGKKGKENEKPCILLIDELDVLVTRNQ-------------SVLYNILDWPTKPNSKLVVLGIANT--DLPEKLLPRISSRMRLCFGNHRQLQEIISTRLEGNAFEKTAIEFASRKVAAISG-DAREICRRAA-----EVADYRLKKSNISAKSQL-------------------------VIMADVEVAIQEMFQAPHIQVMKSVSKLS.................... 674
47 -13.300[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  17  14...........................................................................................................................................................................................................................................................................................................................................................................................................................KLQDVVGQEHITKTLQNALV--------------KFSHAYLFSGPRGTGKTSAAKIIAKAINCEVMEIDAAS------NNGVDEIRDIRDHV-KFAPSVYIIDEV------------HMLTTGAFNALLKTLE----EPPSHAIFILATTEPHKIPLTIISRCQRFDFKRISNDALVGRMKEIL-EGIEAEDEALVLVARAAEG-GMRDSLSLLDQAI................................................................................................. 225
48 -13.200[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  11  32....................................................................................................................................................................................................................................................................................................................................................VSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPE----TQHELAVHKKKIEEVETWL-----KAQVLERQPKQGGSILLITGPPGCGKTTTLKILSKEHGIQVQEFQKDDFKGMFNTESSAVFKEFLLRATKYNKLIILVEDLPNQFYRDSHTLHEVLRKYVRIGIFIISDSLSGDNNQRLLF----------KEIQEECSISNISFNPVAPTIMMKFLNRIVTIEANDKTSLELLCQGCSG----DIRSAINSLQFSSSKNNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLF-RALGKI.................................... 403
49 -12.700[L] KOG0481 DNA replication licensing factor, MCM5 component  ali follow..  17  301...............................................................................................................................................................................................................................................................................................................................................................................GAGAISRYSNITSDEEEHFRRMAASGDIYERLSQSLAP---------SIFGSRDIKKAI--CMLFGGSRKRLPDGLCRRGDINVLLLGDPGTAKSQLLKFVEKVAGSSAAGLTASVMKDPQTRNFVMEGGAMV-LADG----VVCIDEFDKM-REDDRVAIHEAMEQQTISIAKA--GITTTLNSRCSVLAAAN-S-DFMPTILSRFD--IVKDIHDESRDITLAKHIINEPAEGEISLSTFKKYIH-YCRTHCGPRLSEAAGEKLKSRYVLMRSGAGQQEKASDKRLSIPITVRQLEAVIRISESLAKFATDEHVNEALRLFQVSTLD.............................. 649
50 -12.300[L] COG1484 DNA replication protein  ali follow..  13  61......................................................................................................................................................................................................................................................................................................................................................................................................AERKVKRLLGASEITHAFRQLGFKEF--TEGKPQAIKDAFECTKEYVADYEQIKDCRKNSIALLGQPGSGKTHLLTAAANELYVPVIYFPFVEGFTDLFALLEAKLNRMKQA-------VLFIDDLFKPVNGKPRATDWQLE--------QMYSVLNYRYLNHKPILLSSELTIEVDEALGTKIYEMYLVIIKGAAYELN........................................................................................................................................ 259
51 -12.200[L] COG1241 Predicted ATPase involved in replication control, Cdc46/Mcm family  ali follow..  20  279..............................................................................................................................................................................................................................................................................................................................................................................................................................SIFGHDIVKRSI--LLLVGGNEVVMRNGSKIRGDINILLVGDPSTAKSQLLRYVLNAAGSSGVGLTAAVVLDKDTGEKRLEAGAMV-LADR----VVCIDEFDKM-SDGDRVAIHEVMEQQTVTIAKA--GIHTTLNARCSVLAAAN-P-RLPESLLTRFD--VTLDKSNTDIDQLVSGHVLREEEGMGVKQEVFRAYIR-YCRQKKPVLSREAAGLIAREYTSLRQSKDRKEQIVSITPRMLETMIRLATANAKLRLSDV--VEYDDAECAVNLVKDSLFQ.............................. 580
52 -12.100[L] KOG0482 DNA replication licensing factor, MCM7 component  ali follow..  17  306................................................................................................................................................................................................................................................................................................................................................................................INKNDEISDKDAELTPEELEELAQDDFYERLATSLAP---------EIYGHLDVKKALLLLLV----------GGVDKRPDGICLMGDPGVAKSQLLGYISRLAGSSGVGLTAAVMKDPLTGEMTLEGGALV-LADQ----VCCIDEFDKM-ADQDRTAIHEVMEQQTISIAKA--GIMTTLNARVSILAAAN-P-QLPAALLSRFD--LIQDKPDRDNDLRLAKHITYPTRVKALDMNLMRRYIN-LCKRKNPTIPDELTDYIVGAYVELRREARNQKDMTFTSARNLLGILRLSTALARLRLSDS--VEKDDVAEALRLLEMSKDS.............................. 643
53 -11.900[R] COG5545 Predicted P-loop ATPase and inactivated derivatives  ali follow..  11  383............................................................................................................................................................................................................................................................................................................................................................................................................................AERYFGTNDMKRTLIAAVA--AFEPGCKHDEI------TILQGKQKSLKSTFWEILAGE----EFFTDDLNGTEK---DEVLKISQYW---------ILEYAEFENSYKKKDVSQLKAFLSRKKDSMRRPYGTDIEDFPRPSILVGTTNLDEFLDPTGERRF---WVIKVLFKK--AAAVAAYRNGEQLTEVEDEWLDAANKQYQSTDVMAWAELQKEVSVGEILSDVLKIELAKQSKAEQNR....................................................................... 625
54 -11.900[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  16  1................................................................................................................................................................................................................................................................................................................................................................................................................................................TEVKPFF--------VRTVAILGGESSGKSTLVNKLANIFNTTSAWEYGRDYVFSHLGGDEIALQQYIDFAVKYANKVAFIDTVTTQA-----------CKKYEGREHPFVQALIDEYRFDLVILLENNTPWVADG--LRSLG--------SSVDRKEFQNLLVEMLEENNIEFVRVEE-------EDYDS--FLRCVELVREMMGEQR..................................................................................... 187
55 -11.600[L] KOG0480 DNA replication licensing factor, MCM6 component  ali follow..  17  399...............................................................................................................................................................................................................................................................................................................................................................................IEEQDEFLQSLSQEEIDDLRAMVHSDHIYSRLTNSLAP---------SVYGHEIIKKGI--LQLMGGVHKLTPEGINLRGDLNICIVGDPSTSKSQFLKYVCNFLASSAAGLTAAVVKDEETGDFTIEAGALM-LADN----ICAIDEFDKM-DLSDQVAIHEAMEQQTISIAKA--GIQATLNARTSILAAAN-P-NMSAPIMSRFD--VVLDECNESVDRHLAKHIVDDAMQPEFSTEQLQRYIR-YARTFKPKLNTESCAEIVKKYKQLRMDDAQGAGKNSYRITVRQLESMIRLSEAIARANCVDDITPAFVNEAYSLLRQSIIH.............................. 738
56 -11.600[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  11  120.......................................................................................................................................................................................................................................................................................................................................................................................................................NTKHLFDNEGKSNQLARAVGQKLA---------QAPGEPSANPFFLYGGTGLGKTHLLHAIGNGINARVLYIHANNFMQHMVKAVRDNKMDQFKKFYRSLD-ALLVDDIQFFAEK----------EKTQEEFFHIFNSLFETGRQ--IILTSDRYPKEIEERLKSRFGWGLTTAIPDLETRVAILLKKAEEHNMN--ELEGALNRVKAMQDFKGGDIDIDFVRDTLKDILALQERLVTIENIQKVVAEVSDLKSKSRARSVTRPRQIAMALAKELTNRSLPEIGRAFDRDHTTVLNACREVPKFREQDNSIQEDWA... 446
57 -11.500[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  13  40.............................................................................................................................................................................................................................................................................................................................................................................................................................DLLLHRNEQINSLATILVSALR----------ETPSNVLIYGKTGTGKTAVTRYVGKELFCSVVYINCEVIDTQY--PTDQVFMKFKEIDARDQVIIIILDEIDKLIKKGD-------------DVLYNLSRINTDRKAKVSMIGVSNDTEFLDPRVKSSLEEELIFPPYDAEQISDILKQRAKDGVLGEMVIPLCAAFAAQEHG-DARDLLRVSGEIAERE--------------------------------------NQPQVLEEHVRRAQEKIEIDRVVEVVRTLPTQS.................... 310
58 -11.300[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  15  12...........................................................................................................................................................................................................................................................................................................................................................................................................................DLLGKDGVDYHIEQANHLKFLS------------DCMPHLLFCGPSGAGKKTRIKCLLRESSNYHIEMTPSDVGIYDRVVVQDLVKEMAQTSQIESTSVVVLCEADSL-----TRDAQHGLRRTMEKY-----------ANNCKIVLSCESLSRIIEPLQSR--IIINVPAPTDEDVTKVLRKVIERELLPENVLQKIVEKSEGNLRRAILMT...................................................................................................... 232
59 -11.200[L] KOG0478 DNA replication licensing factor, MCM4 component  ali follow..  16  437...................................................................................................................................................................................................................................................................................................................................................................................EGKDHIFPPERVELLQLLAKKPDIYDRLARAIAP---------SIYENDDIKKGILLQLF-----KKKHATLGRQNFRSLLLCGDPGTSKSQMLQYVFNLVGSSAVGLTAYVTKDPETRQLVLQTGALV-LADN----VCCIDEFDKM-NDSTRSVLHEVMEQQTLSIAKA--GIICQLNARTSILAAAN-P-QLPHTLLSRFD--LVLDPQDEIFDKRLASHLVSEEEDTMFDMSVLRDYIA-YAREHLSPTLSDEAQQRLIQAYVDMRKVGAGRGQISAYPRQLESLIRLSEAHAKVRLSNQ--VELLDVEEAWRLHREALKQ.............................. 773
60 -11.000[S] COG4983 Uncharacterized conserved protein  ali follow..  10  469............................................................................................................................................................................................................................................................................................................................................................................................................................LAYLIPIEAERVRFEQWLAHIVQRPEELPQSAY-----LFITEETGIGRNWLSSVLVRVLRGVAAGIDIQELDGTFNGRLSRKL-------------LAVVDEAKAGMQGYGRWSHSEKLKSMINPEMRRINEKHGLEWNCCRWLFFSNNWDALPFD--RRF---NVVANPTHRQSPDYYERIYSQIANPDF----ISAVRKRLELLDISGF-AIPDMNEAKRKALGAMASDLDNLLAAFRDEWPGPLAERSDVINYLHVSIAKLPGEKTINKLIEQAGMKLVER............................. 736
61 -11.000[T] COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains  ali follow..  14  134............................................................................................................................................................................................................................................................................................................................................................................................................................RNAIVTRSPLMLRLLEQA-----------RMVAQSDVSVLINGQSGTGKEIFAQAISPRSNKPFVAINCGALPEQLL-ESE-HARGAFTGAVSNRE-TLFLDEIG------------DMPAPLQVKLLRVLQGSNRDIDIDVRIISATHR--DLPKAMARGEFREVSLKIPALAERTEDIPLLANH--------QRHKPFVRAFSTDAMKRLMTASWPGNVRQLVNVIEQCVALTSSPVISDALVEQALEGENTALPTFAEARNQFELNYLRKLLQITKGNVTHAARMA......................... 422
62 -11.000[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  15  551..............................................................................................................................................................................................................................................................................................................................................................................................................................PLVGHMDEQTKLYQWVRQTIVLGE----------NSVIIVGPRGSGKSVLVDDILSRAAQEVVRLNGTYQTDD-FSDTLTKLLATLSHPVDLGAVIFVLEEFDLFVQHSRQM------------LLYNLFDIAQSRKAPILIIGLTTR--DCSESLEKRVKSRIPMRPPSLSEFEQILKSVLYDEGGKDQIITCWNQRVDELLSDTRSHL...................................................................................................... 790
63 -10.600[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  20  4................................................................................................................................................................................................................................................................................................................................................................................................................................................................PNILLTGTPGVGKTTLGKELASKSGLKYINVG--------------------DLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIVD-DFFPERWFHIVFVLRTD-------NVLYERLETRGYNEKKLTDNIQCEIFQVLYEEATASYKEEIVHQ-LPSNKPEELENNVDQI-LKWIEQWIKDHNS.................................................................................... 172
64 -10.600[F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)  ali follow..  14  3..................................................................................................................................................................................................................................................................................................................................................................................................................................................................IAITGTPGVGKTTVAKLLAKKLNYEYVSLKGRRVNDEVEVEIDELAYFIERELKG-VDLVVVLRAHPKLIGERRGYDREKIGENVEAELVDAVLIEAIEEHENVIEVDTTNKPEDVVEEIVSLINSG-------------------IKKRVGIVDWSEVYDEIIPYLGGE.......................................................................................................... 180
65 -10.400[L] KOG0477 DNA replication licensing factor, MCM2 component  ali follow..  18  446...............................................................................................................................................................................................................................................................................................................................................................................KKDNKVAVGELTDEDVKMITSLSKDQQIGEKIFASIAP---------SIYGHEDIKRGL--LALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSGASAVGLTAYVQRHPVSREWTLEAGALV-LADR----VCLIDEFDKM-NDQDRTSIHEAMEQQSISISKA--GIVTSLQARCTVIAAAN-P-DLTEPIISRFD--VVRDTVDPVQDEMLARFVVGTYGVEPLPQEVLKKYII-YAKERVHPKLNQMDQDKVAKMYSDLRKESMATGSIPITVRHIESMIRMAEAHARIHLRDY--VIEDDVNMAIRVMLESFID.............................. 804
66 -10.400[L] COG3598 RecA-family ATPase  ali follow..  12  363................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGVLIAGPSKAGKSFAL-SIALAEGQKWLGWQCEQGKVLYVNELDKLAPKLIRRSLKKNYQAVIIDPIYKVLTGDENSADQ------MAHFTNQFDKVATELGCSVIYCHHHSKGSQ-SGVFARDPDALIDLVELELTEDLIKARSEKAAAKIYQQALQEKALGYYQQEVTLDDLESRYQMQQHFDKAIKDIMVKQPYLEAVKKAQHEVEIATAWRVDGTLREFAKFQPVNMWFSYPKHEVDTTGVLADIQLEDSKPLWKKAKEARKSKEENL..... 687
67 -10.400[L] KOG0479 DNA replication licensing factor, MCM3 component  ali follow..  15  270..............................................................................................................................................................................................................................................................................................................................................................................IQMLSKEVIPNFEPQDVKDVRKISKSRNPFELLARSLAP---------SICGHEETKKAL--CLLLGGMEKILNNGSRLRGDINVLLIGDPSVAKSQLLRYVLRMAGSSGVGLTAAVTTDPDSGERRLEAGAMV-LADR----VVCIDEFDKM-SDIDRTAIHEVMEQGRVTISKA--GIHAKLNARCSVLAAAN-P-GMQDSLLSRFD--VLLDEHDADKDANVAEHVLKIQDTKILTMDFMRKYIH-LARSVQPKLTDEATEYISEVYADIRSFDITKTDQERTMPVTARQLETLIRLSTAIAKARFSKVEREDTEKAYNLLHFACFKEKPKARQEYEKKKRAPRIDGDDDED..... 677
68 -10.100[V] COG3896 Chloramphenicol 3-O-phosphotransferase  ali follow..  12  26..................................................................................................................................................................................................................................................................................................................................................................................................................................................................ILLNGGSSAGKTSLALAFQDLAAECWMHIGIDLFWFALPPELDLAMHSRYRAIRAYLDN-VIADDV-EEGARRELERGDRHPGWNRGSA----RAAHADAEYDFELDTTATPVHELARELHESYQAC-----PYPMAFNRLRKRFLS................................................................................................................................. 225
69 -10.100[R] COG2842 Uncharacterized ATPase, putative transposase  ali follow..  10  94..................................................................................................................................................................................................................................................................................................................................................................................................................................................................ATVYGMSGVGKTKAIQEFAKSSLSEILYEIALELGISDAPRRKGTLSRLIARKIKGTEGLLIVDEAD----------------HLPYEALEELRIMQEEAGIGLVLVGNDKVYTRMKARLWSRVAKNTSIQKTKKADTQAVAQAWGLETDEEALKVMQSITETGGGLRILTQTYACRNGSKRIWQV.......................................................................................... 286
70 -9.690[U] COG3267 Type II secretory pathway, component ExeA (predicted ATPase)  ali follow..  17  2............................................................................................................................................................................................................................................................................................................................................................................................................................YLNFFGFDELPFSIVRYLYLSQRHQEAIVHLQLGDGGGAMLTGEVGTGKTTVARAILASLPGKT-TFSDLELLEAICDE-QVLHEFLLAEHAQGIQVLLMIDEAQHLAPD-------------VLEQLRLLTNLETESHKKVLLIGQPELQEKLRLPQLRQLAQRITGPLNEEQTADYIRFRI-NPELFNRKACQWIAEQTHGIP---INLVCDAALKQAYQA........................................................................................... 248
71 -9.660[R] COG0645 Predicted kinase  ali follow..  16  4..................................................................................................................................................................................................................................................................................................................................................................................................................................................................AVTHGVSAVGKSQVAMRLVEALGAVR--LRSDIERKRLFGASEATYAHLHQLAAKILQA-VVID---AYLKQNQRQAACHIAEETGVPFL-------------ILDCQAP------EAVIAGWLAQRQAEGKDPSDATLDVIRTQQATREPLTAAETVQSKRVDTHDAASLDGLVDGI.................................................................................................. 178
72 -9.560[K] COG2909 ATP-dependent transcriptional regulator  ali follow..  11  3.........................................................................................................................................................................................................................................................................................................................................................................................................................................IPSKLSRPVVRDRLLVKLSSAANYRLLINCPAGYGKTLIAQWAADQSNLGWYSLDESDSQKHQYANLSALFSQLFILSNWDGPLYLVIDDYHLI--------TNDAIHEAMRFFLRHQPE---------LIILSRTLP-SLGIANLRVRDQLLELGMQQLAFNHHEAQQFFECRPLEQGDSSRLCDEVEGWTALQLIAL----------------SSRQPNSSAQKSAKRLAGLNASHLSDYLVDEVLDQVDSKARAFCSVLRSMNDALIV.............................. 286
73 -9.560[R] COG1855 ATPase (PilT family)  ali follow..  15  243.................................................................................................................................................................................................................................................................................................................................................................................................................................ADRMEITAVRPIAQVSIDESEELKRRIVERQRGILISGPPGAGKSTFAASVANFLLENGYIVKTME-EITQYAPLEGDMSLTSDILLLVRPDYTIYDEL-GMIGVTHATRAVDAIQRMIGRV-----GMIPQVVDTVVFIDA--------GRIVKVYELSFTVKVPTGMTEADLARPVIEVRDFETKNLEY-----EIYTYGE------QVVVMPIETDENLKAALEEKISKYVDDFEVEMVGRKAVIKVPEKHIPTLIGRKGRRIKNIEDEFKISIDVI............................. 527
74 -9.500[R] COG3903 Predicted ATPase  ali follow..  16  3.........................................................................................................................................................................................................................................................................................................................................................................................................................................................QEVLTNYRLVTLRGEGGVGKTRLAIQIAAASGLCFVDLAPSTTAAHALGLIDRPGSSTFDTLSHACHMLMVLDNCEHVL---------DACAELVVELLGACPELS--------ILATSRESIGVTGEVTWVVP----LSPANEAIQTERARLVQPNFEIVADNFDAVSEICRRLDGMPL---AIELAAARLRSLSPNEIAN-----------------------------------SLDDRFRLLTGGARSTVQRQQTLRASMDWS.................. 227
75 -9.350[V] COG1401 GTPase subunit of restriction endonuclease  ali follow..  23  225............................................................................................................................................................................................................................................................................................................................................................................................................................................................PQLPKNTILYGPPGTGKTYCTIELAAEKRVRFITFHQSFGYEEFI-TDDGNVRGIFSVSEKRQNYVLIIDEIN-----RGNIS------KIFGELITLIE-LPYSSSNNLYLIGTMNTAD-LDTALRRRF--EFEAMLPDIT--------VLKETVVKGIDLPRLLQTLNGHA-ERLKRIMRNKVLPLLEEYF......................................................................................... 603

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.