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Query: [T] KOG0787 Dehydrogenase kinase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVLGKTLQEKVNLLAQYPQTGLSLKQLVYFGKNPTPGTLFRAGLFLRDELPIRLARRIQDLQNLSPMLRSMKRISSVKAAYGRSMEEIIELKGVELPKCLPKHARYHNAPKWRSSLMDSEILHNPSLANTHLDSSKGRYFETDFSDQDNGVDCNWPESLLKFNSNFAYLLNTIRTRHDNVAVEIALDIQEYRRKTNQIDNSIQIFLDRFYMSRIGIRMLLGQYIALVSEPPRENYVGVISTRANIYQIIEGAAENAKYICRLAYGLFEAPEIQIICDPSLEMMYVESHLNHAVFEILKNSLRATVEFHGVDSDFFPPIKVIVAKGQEDITIKISDEGGGISRRNIPLVWSYMFTTASPTLTDDPHDIVSANSTTPMAGFGFGLPLARLYTRYFGGDLELISMEGYGTDVYIHLNRLCESAEPLQLast
1 -104.000[T] KOG0787 Dehydrogenase kinase  ali  100  1MSVLGKTLQEKVNLLAQYPQTGLSLKQLVYFGKNPTPGTLFRAGLFLRDELPIRLARRIQDLQNLSPMLRSMKRISSVKAAYGRSMEEIIELKGVELPKCLPKHARYHNAPKWRSSLMDSEILHNPSLANTHLDSSKGRYFETDFSDQDNGVDCNWPESLLKFNSNFAYLLNTIRTRHDNVAVEIALDIQEYRRKTNQIDNSIQIFLDRFYMSRIGIRMLLGQYIALVSEPPRENYVGVISTRANIYQIIEGAAENAKYICRLAYGLFEAPEIQIICDPSLEMMYVESHLNHAVFEILKNSLRATVEFHGVDSDFFPPIKVIVAKGQEDITIKISDEGGGISRRNIPLVWSYMFTTASPTLTDDPHDIVSANSTTPMAGFGFGLPLARLYTRYFGGDLELISMEGYGTDVYIHLNRLCESAEPLQ 425
2 -46.000[T] COG5002 Signal transduction histidine kinase  ali follow..  14  201..FLARTITHPLSDMQAMELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEIERDDELTVLRVNFSVIQREHDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPLTTMRSYLEALAE---GAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFD--SKDYQFNREWIQIVRFMSLIIDRFEMTKEQH-----VEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYSPEGGHVT------FSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYR-------------VDKARTRKLGGTGLGLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWD 609
3 -33.300[T] COG0642 Signal transduction histidine kinase  ali follow..  13  227.........................................................................................................................................................VEKLEKLVAKERHLLHHVSHEMRSPLARMQAIVGLIQA-------QPQKQEQYLKRLEGELTRMDTLAGELLTLSRLE--TSNMALEKESLKLLPFLGNLVEDNQSIAQKNGQTVTL-SADGKIPENTTILANESYLYRAFDNVIRNAVNYSPEGST--------ILINIGQDHKHWIIDVTDNGPGVDEMQLPHIFTAFYRA---------------DSSANKPGTGLGLALTQHIIEQHCGKIIAENIKPNGLRMRFILPKKKTGSKT.. 463
4 -29.600[T] COG4192 Signal transduction histidine kinase regulating phosphoglycerate transport system  ali follow..  12  542.............................................................................................................................................QRAEAHLKKTQGELIQAAKMAVVGQTMTSLAHELNQPLSAMSAYLFSARLALEEA--PQAQLATSLDHIENLTERMGKIVNSLRHFARKNSSDESL----QPVRLNSVVEQALVLVQTKAKRQ-----QIKLINTLPDDLMVMADALSLEQVLINLIVNGCDASTTFAQ------PWVKLIALGTEQGQRIAVIDSGQGFEHEVVDKLFTPFTTTKEV-------------------GLGLGLSICQSLVEKMQGRIALASNLEKGAMVILELQQDEKYRT... 787
5 -29.400[T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation  ali follow..  13  298..AVADRLVRPIRQLAADEVATGNLDVAVPVSSDGDVASLGDTFNKMLLELKSQRNEILSAKDLIDIGVDPYGIVTIVNRSAESMLASASAALGQNLSAILPHVGRVFEIGRQSGKPVYREQVTFFRAGTERTFNVQITIEAGDDGVTVDDITDLVQAQRSSAWADVARRIAHEIKNPLTPIQLSAERIKRYGKVITEDREVFDQCTDTIIRQVEDIGRMVDEFSAFARMPKPE-------KAIDLRESLREASFLVEV-------SRADITFERIFGNEPKGTFDSRLLAQAFGNVIKNAAEAIDGLEQKDGSH--IIRIQAGRQNGAIRIDVIDNGKGLPRENRQRLLEPYMTTREK-------------------GTGLGLAIVKKIVEDHGGRLELHDAPGRGAMISIILPLAAVTPLR.. 720
6 -29.200[T] COG3852 Signal transduction histidine kinase, nitrogen specific  ali follow..  15  112.................................................................................................................................................DNQRRLSQEQLQHAQQIAARDLVRGLAHEIKNPLGGLRGAAQLLSK-----ALPDPALTEYTKVIIEQADRLRNLVDRLLGPQHPGM--------HITESIHKVAERVVALVSMELPDN------VRLIRDYDPSLELPHDPEQIEQVLLNIVRNALQALGPEGGERTRTAFQLTLHGERYRLAARIDVEDNGPGIPPHLQDTLFYPMVSGREG-------------------GTGLGLSIARNLIDQHAGKIEFTSWPG-HTEFSVYLP.......... 346
7 -28.700[T] COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system  ali follow..  13  384.............................................................................................................................................RQTTEKLQAVQQDLVQANRLAILGQVAAGVAHEINQPVATIRAYADNARTFLHRG--QTVTAAENMESIAELTERVGAITDELRRFARKGHFA------AGPTAMKEVVEGALMLLRSRFAGRMDAIRLD----LPPDGLQALGNRIRLEQVLINLLQNALEAIGDSED------GAIQVRCEEAAGGIALTVADNGPGIAADVREELFTPFNTSKED-------------------GLGLGLAISKEIVSDYGGTIEVESGPS-GTTFAVNLKK......... 620
8 -27.000[T] COG3290 Signal transduction histidine kinase regulating citrate/malate metabolism  ali follow..  14  322................................................................................................................................................................................RDKTEVRKLMQRLDGLVNYADALRERSHEFMNKLH--------VILGLLHLKSYKQLEDYILKTANNYQLLGKIKSPVIAGFLISKINRATDLGHTLILNSESQLPSEDQVATLITTLGNLIENALEALGPEPGGE------ISVTLHYRHGWLHCEVNDDGPGIAPDKIDHIFDKGVSTKG-------------------SERGVGLALVKQQVENLGGSIAVESEPGIFTQFFVQIPWDGERSNR.. 543
9 -26.300[T] COG2205 Osmosensitive K+ channel histidine kinase  ali follow..  12  645..............................................................................................................................................ERLHLARSAELAKLDAEREQLRNSLLAALSHDLRTPLTVLFGQAEILTL---DLAAEGSRHAPQANQIRQQVLSTTRLVNNLLDMARIQ--SGGFNLRKEWQSLEEIIGSALYMLETTLSQHQIRVELP------DEMVLINCDASLLERVFINLLENAHKYAGHAA--------LLGIRAEVQGEWLNVDVWDNGPGVTIGQENLIFDKFSRG---------------NKESAIPGVGLGLAICRAIIDVHGGRIWVEKRQEGGASFRFVLP.......... 883
10 -23.300[L] COG1389 DNA topoisomerase VI, subunit B  ali follow..  22  27..............................................................................................................................................................................................................................................................................................AKAIITVVKEAVDNALDACEEAG-----ILPDIFVRISKVDDHFKIVVEDNGPGIPREQIPKVFGKLLYGSRF-----------HEIRQSRGQQGIGISAAVLYAQLTTGKTVISKTPDEDRAKKVVLYINTKKNEP.. 149
11 -16.800[S] COG5381 Uncharacterized protein conserved in bacteria  ali follow..  11  73.............................................................................................................................................................................................................................................................................................IKGSVSYIANELLENAVKYSTTDHDC------PITITLHLYDHKLIFETSNISPLPTTIDYENFIKVLLEADPLE-----MERLEKSALEDCEASQIGLTMINDYQAQFGWRFVPVSGSEDLIKVTVMTH.......... 194
12 -16.800[T] COG3850 Signal transduction histidine kinase, nitrate/nitrite-specific  ali follow..  11  176VVRPLNQLVTASQRIEHGQFA----PLPLDTSLPNELGLLAKTFSQMSSELHKLYRSLEASVEEKTHDLHEAHRRLEVLYQCSQALNTVGDNWRISEGTQSPDLPMQMLPVTMQDTVYGELHWQSPNVNASTPLLNSVSTMLGRGLYFNQAQKHFQQLLLMEERATIARELHDSLAQVLSYLRIQLTLLKRIPEDNAGAQSIMADFSRALNDAYRQLRELLTT-------------FRLTLQQADLPSALHEMLEDLQSQTP-------KLTLDCRLPTLALDAQMQVHLLQIVREAVLNAIKHA---------NASEIAVSCVTAPDDHTVYIRDNGIGIGEPHEPA--------------------------------HYGLNIMRERAERLGGTLNFSQPSGGGTLVSISFRSSNKEESQLT 566
13 -15.800[NT] COG0643 Chemotaxis protein histidine kinase and related kinases  ali follow..  14  269.................................................................................................................................................................EKVDQLINLVGELVITQSMLAQRSSELDPVNHGDLITSMGQLQRNARDLQESVMSIRMM------------------------PMEYVFSRYPRLVRDLAGK---LGKQVELTLVGSSTELDKSLIERIIDPLTHLVRNSLDHGIELPEKRLAAGKNLILSAEHQGGNICIEVTDDGAGLNRERILAIFAPGFSTAEQ---------------TDVSGRGVGMDVVKRNIQKMGGHVEIQSKQGTGTTIRILLPLTLAILDGM. 515
14 -15.700[T] COG4251 Bacteriophytochrome (light-regulated signal transduction histidine kinase)  ali follow..  11  504.........................................................................................................................................................AGERERAEVRQRMLNEELNHRVKNVLAIIKSLVGNPSQ-------EGKTLQEYVTALKGRIQALSFAHDQIIRGEGGG-------------ALRDLLEAELSPHRS---------PETTVKLEGPQITLDSRAFSVMALVLHELATNAAKYGALSQNG-----GQLHVRWDNENRDCEISWRETLLTTLPAPSRA------------------------------GFGTAL-ISRSIPYDLGGRSTIRYLPN-GLEAEILLPFRHVSSVS.. 708
15 -15.400[T] COG4564 Signal transduction histidine kinase  ali follow..  14  206..............................................................................................................................................................................MLLNLRERRMADTKLKELAQRIIDTQEEERARLARELHDGISQNLVVRYAIDLASRQVRTGSGGAPQAIEKASDALNGAIKEVRRLSHDLRPRI-ETRFKADSLQETIKPEPSTALYRVVQEALTNVERHS---------GATRVDIRLKGAHGKVTMTIADNGNGFAVRGLKD-----------------------------PLSGLGLRNMQERMAHFGGVLLVET-SADGTQLTARLPKSATERRL.. 434
16 -14.100[S] COG5385 Uncharacterized protein conserved in bacteria  ali follow..  7  1.............................................................................................................................................................MPVTLSALDLGALLCSRICHDIISPVGAINNGLELLEEGSADEDAMALIKSSARNASARLQFARIAF--------AAGSAGVQIDTGDAQNVATEYFRNEK----------------PEFTWEGARVLLPKNKVKLLLNMLLIGNGAIPRGGSLA------VRLEGGDTDPRFVITVKGRMLRVPPKFLELHSGAAPEE-------------------PIDAHSVQPYYTLLLAEEAGMKISIHATAE-DIVFSAE............ 207
17 -13.500[T] COG3275 Putative regulator of cell autolysis  ali follow..  8  190ILLDRKTIFEEYSATFSRRALNIAERSVGILAAGFNPENANKIARIVYEQTNVGAVSITDREKILAFVISSQSTLDAINRNAIIYLDGKEHPYQCSLSPTCKLGSALIIPLRAGDRVIGTIKLYEPKRKLFSTINMSMAQGIAQLLSSQILYGEYQQKQILLSRAEI-KLLQAQVNPH---LFNALNTISAVIRREPDKARELILHLSQFFRSNLK-------------------------QNVETVTLREELAHVNAYLTIEKARFSDRLDVEIAIDDALLERNVP---SFTLQPLVENAIKHGTSNLLEAGK----VRIYSEVVEGGMRVVVEDNAGLYQPPSED-------------------------------YDGLGMQIVEKRLTNKFGLLQIEVAPQEYTRMSFVIPQQGT...... 557
18 -13.300[T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain  ali follow..  12  346...........................................................................................................................................................................QDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPHFLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTQRFRFEERLKFTLDIDDEVKHCLIP---KLTLQPLAENAIQYALEPFTRPCA----IRIQAKKAKGCVCITVEDNGPGMDGRILEST----------------------------GGRGIGLWNIRERISLTFGELRIHSEHEKGTRIVITIPCRNEV..... 576
19 -12.900[T] COG2172 Anti-sigma regulatory factor (Ser/Thr protein kinase)  ali follow..  15  42...............................................................................................................................................................................................................................................................................................EDIKIAVAEACTNVVDHAYDEGG-------TMGLSFHLYEDRMEIIVTDQGQSFDMDAFR---------------ESLGPIDGSKPIQDLKEGGLGLFLINTLMD----KVEMKEDSGVVLAMTKFLQRDEVDNRV.. 151
20 -12.700[T] COG3851 Signal transduction histidine kinase, glucose-6-phosphate specific  ali follow..  15  275............................................................................................................................................................................QRLRELNQSLQKELARNQHLAERLLETEESVRRDVARELHDDIGQTITAIRTQAGIVQRLAADNASVKQSGQLIEQLSLGVYDAVRRLLGELEGRGIVSHLEWRIDESALSENQRVTLFRVCQEGLNNIVKHA---------DASAVTLQGWQQDERLMLVIEDDGSGLPPGSGQQ--------------------------------GFGLTGMRERVTALGGTLHISC--LHGTRVSVSLP.......... 497
21 -10.600[T] COG4585 Signal transduction histidine kinase  ali follow..  9  160............................................................................................................................................LLDEYRKMKRQLLTEEEQARQDERMLIGHEIHDSVGHKLTALVMQLEAFRLT------AAEQDKETIESL--KVLAERSLEETRRAVKSFKHKE----------------LQGVIRLIRKLEMESFMNIHFSVKHGAFAAPLTGEQSFAIYRAIQEALTNIMKHSSTR---------EAQVLFESPGGSFRFEVLNAAPP----------------------------------NPFFQEGYGLKGMRERLEKVGGSLAIVQNER-QFIVTGSIRLFERRGSY.. 378
22 -10.500[D] KOG1845 MORC family ATPases  ali follow..  18  120....................................................................................................................................................................................................................................................................................................ALAELLDNSLDEVSNGATY-------VDSTINKRDGKSILIVEDNGGGMNPSTFRECLSLGYSR-------------KRNMANRVGQYGNGFKT---------STMRL------GADAIVFSRSRGING.... 216
23 -10.500[O] KOG0020 Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family  ali follow..  12  45..........................................................................................................................................................................................................................................................AETLKREEEAIQLDGLNVAQLKEIREKAKKFTFQTEVNRMMKLIIELISNAIRLLALSNSKELETNPELHIRIKADKENKALHIMDSGIGMTHQDLINNLGTIAKSGTAAKMQDPSKSEGLDMNDMIGQFGVGFYSAFLVAD----RVVVTTKHKRGSVISLYLK--EEAQDFLE 260
24 -9.530[O] KOG0019 Molecular chaperone (HSP90 family)  ali follow..  15  90.......................................................................................................................................................................................................................................................................................DLIVHSLYSHKEVFLRELVSNALRFLSVTEPSLLGDGGDLEIRIKPDPDNGTITITDTGIGMTKEELIDCLGTIAQSGTSKFLKALKENKDLGADNGLIGFGVGFYSAFLVAE----KVVVSTKSRRGTQITLYLRE-DDKYEFAE 267
25 -9.240[O] COG0326 Molecular chaperone, HSP90 family  ali follow..  20  35..................................................................................................................................................................................................................................................................................................EIFLRELISNALRFKALSNPALYEGDGDLRVRVSFDADKGTITISDNGIGMTREQVIDHLGTIAKSGTKEFLTALGQDQAKNSQ--IGQFGVGFYSAFIVAD----KVTVKTRKSRGTDVILHLR--EDEKEFLN 195
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lukasz Jaroszewski, Zhanwen Li, S. Sri Krishna, Constantina Bakolitsa, John Wooley, Ashley M. Deacon, Ian A. Wilson, Adam Godzik, Exploration of Uncharted Regions of the Protein Universe. Plos Biology. 2009 Sep. 7(9):e1000205