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Query: [R] KOG0814 Glyoxylase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLAALKRLSTNQPPTLVSNIRYLSSFGTMSLPERQPFSPDFFFRQLFDGESSTYSYLLADLKNGQAVIIDPVLEQAKRDAQLVKDLGFELKYAINTHMHADHITGSGWLRKLTGCQSVIAAASGAKADRHLNEGDRIDFGTHVIDALATPGHTNGCMTYVIKDQGCVFTGDTLLIRGCGRTDFQEGCPRNLYENVHSKIFTLPENFRIYPAHDYKGQMESSVWEEKRYNPRLTKDIEEFVKIMENLNLPYPKKILast
1 -106.000[R] KOG0814 Glyoxylase  ali  100  1MLAALKRLSTNQPPTLVSNIRYLSSFGTMSLPERQPFSPDFFFRQLFDGESSTYSYLLADLKNGQAVIIDPVLEQAKRDAQLVKDLGFELKYAINTHMHADHITGSGWLRKLTGCQSVIAAASGAKADRHLNEGDRIDFGTHVIDALATPGHTNGCMTYVIKDQGCVFTGDTLLIRGCGRTDFQEGCPRNLYENVHSKIFTLPENFRIYPAHDYKGQMESSVWEEKRYNPRLTKDIEEFVKIMENLNLPYPKKI 254
2 -76.400[R] COG0491 Zn-dependent hydrolases, including glyoxylases  ali follow..  22  1........................................MEILGFAAGPYKTNCYVVRGE--NEVAIIDPGMHAHDDLVEYITTNNLSVDKIVLTHGHIDHTRDAGVVAKRFNAPVYIHPDDAPESLRDLVDGETITLAGEEFTLKHAPGHSPGCTLIVGKE--YCFSGDVLFKGSIGRTDFEWSDADAMNESLRTAVLPLDDALQILPGHG----PTTTMRAERTGNPFLLA.................... 212
3 -38.400[R] KOG0813 Glyoxylase  ali follow..  16  29...................................................GTNTYLLGSGS--RRILIDTGDEDVPQLGDVLQQEKASIDTILLTHWHHDHVGGVKSIVGTKLAEKDCRVFKFGRTDHPLAHNQEFTTEGANVRVVHTPGHTTDHVVLAMNE-GTLFSGDCIL----GEGTAVFEDLFEYMKSL-EKILDIKPQR-IFPGHGNVIEEPIGKIEYYINH---NQREQQILQFFVQ......... 229
4 -22.000[S] KOG4736 Uncharacterized conserved protein  ali follow..  12  294..................................................AVGAITLV--NDNGYIVLIDTGASDTERLLHSLAKESVTIDSVVITHASPGHMGNMNFFAQ---KPILYHSMEVTPTELKERPYRKLSGN---VEVWKTPGHTQHDLSVLVHNVAMAIVGDLIPSEHEKRDVMIEEGVWDNAIKRQNANLIVCMADWIVPGHGQPFRVLPNYRQKAGCTRLLAQRHL................. 488
5 -21.000[C] COG0426 Uncharacterized flavoproteins  ali follow..  16  1MVSMSTTGNAHTENVQHRLTVETVEIAPNTTAIRCLDWDRDRFDIEFGLQTTYNSYLIRGE---QTVLVDTSHQKRQLYLETLKGL--AIDYIIVSHTEPDHSGLVEDVLQLARATVLASKIALQFLEGLVKSGDRIDIGKHEIEFVSAPNHWPDTIFSYDRKTEVIYTCDAFGMHFCDNRTFDEDLEAIEADFRFKRMGDLGKIKIIANGHG......................................... 244
6 -18.600[R] COG2248 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali follow..  13  1MILGLPVGSRGSLAWEWRRTVDPQVPGSNPGILTTFKAINMKVIPLASESLGVRSLALFLKIGKVGILIDPGVKALSLAREKIQEYAKKAQIVTISHYHYDHHTPFFEGSQKKRAHEFLKNAKEIAKDIKFADSQSFDFGSFTIEFSPPVPHGREMVLVDDGKKSVLHASDTILIAGGPPTYLAHRVGNVKEIGMKNRIISETNAKIVLDHHIIRDKGYERFFSELDER-PLEAYRRELHKLEKGEEVEVPG.. 342
7 -17.700[Q] COG2015 Alkyl sulfatase and related hydrolases  ali follow..  129....................................................ANITFVKGDTG---IVFDPLTATAKAALDFVNQEERPVKAVVYSHAHADHFGGVKGIVSQEQVPIIAPKG--APTKVISEQTETVVIDGVTMEFQNTPGESPAEMNTYFPQFKALWMAENTVGGLHNVYTLRGADAKAWSKYINEHMYAKEADV-MFASHTWPRWGNDNINHFRKQRDMYGYIHDQALRLANHGEFHVPDVL 401
8 -16.600[J] COG1236 Predicted exonuclease of the beta-lactamase fold involved in RNA processing  ali follow..  14  47..............................................................ELRTFSIDTTRSPGKQ----------QPDAYLITHAHSDHHGKSAMLSPRATATALEIRHDRKYVGSMCRLGDEIEIEGVRVKTYPT-AHTAGAAAFYWEGTRILVTGDVLITEANGDPEDPSCHFADDLESMKCAL---ESGPVAFGAY--------EFGKAQ-----------RAVELMRGFGYEGAIRM 227
9 -15.400[R] COG2333 Predicted hydrolase (metallo-beta-lactamase superfamily)  ali follow..  13  76.................................KQLSKPTWQVDTLDVG--QGLATLI--VKNGKGILYDTGSSWRGEILPYLQREGIVLEKLILSHDDNDHAGGASTILKAYPNVELITPSRKNYGETFCTAGRDWHWQGLHFQILSPHNVVTRAILVDDGKNSVLLTGD-----------AEAKNEQIFART------LGKIDVLQVGHHG--SKTSTSEYLLSQVRPDVA-----IISSGRWNPWKFPH.. 282
10 -14.300[L] KOG1361 Predicted hydrolase involved in interstrand cross-link repair  ali follow..  156..................................................................FTVDAFRYGCVQ----------GCSAYFLTHFHADHYIGLT--KAWSHGPIYCSSLTSRLLRLSLS-DVEYTINGIKVTLIEA-NHCPGAALIHFRLLDYLHTGDVLYLDTT-RYKFPSKEDSYVVRITKDFLRKQPKTLIVVGSYSIGKECVLAIAKALGVKIFANASRRRILQSFGWDDIS..... 363
11 -12.400[R] COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily  ali follow..  17  12...............................................VREFGKNMYLV--EVEEQIFVLDLGVDFVIPDITYLLENADRVAGIFLTHGHADSIGALPYIVSELKVPVFGSELTIELAKINVKNDTEIDFGKAVISFFSTTHTIPESLGIVISTNNIVYTGDLALLSSSPNALSTMASEHEIYEKIYDYIDDNEGRVIIACNAGNLGRIQQTIDAAIKLGRRVGEDMDQIIETATRL........ 266
12 -12.200[A] KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit)  ali follow..  17  1.....................................MPDIKITPL-GQDVGRSCLLL--SMGGKNIMLDCGMHMGYNDERRFPDFSYHIDCVIISHFHLDHCGALPYMSEIVGGPIYMTHPTKAIAPILLEDMRKVAVERKGESNFFTAGHVLGAAMFWIKSQSVVYTGDLLISESTTTIRDSKRCRERDFLKKVHECVAKGGKVLI---------PVFALGRAQELCILLE-------TYWERMNLKYPIYF 267
13 -12.100[A] KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit)  ali follow..  11  1...................MASSSTSLKRREQPISRDGDQLIVTPL-GSEVGRSCVYM--SFRGKNILFDCGIHPAYSGMAALPYFD-SIDVLLITHFHIDHAASLPYFLEKTTGRVFMTHATKAIYKLLLTDHQTVEVNGIKFWCYTA-GHVLGAAMFMVDGVRILYTGDICIIESTVQLHQSRHIREKRFTDVIHSTVAQGGRVLI---------PAFALGRAQELLLILDEYWAN................ 269
14 -12.100[T] COG5212 Low-affinity cAMP phosphodiesterase  ali follow..  15  1................MHAALEIKEAEFQTDQVVGLVENSFTLYSLGQNESCCSSHLISDGAFQEIISLDGGS-ENESYAKAWHLSEQRIKTFLITHCHLDHIYGAVINSAMVGLNYVIDTLKKHVFNQVVEPSMYTSLTTLSILPFPVN-HGSSSSAFLFSDRYFLAFGDV--------MVASEPLNIHIWRACSSLIAQRKLSHILIEGH.......................................... 270
15 -11.300[R] KOG3798 Predicted Zn-dependent hydrolase (beta-lactamase superfamily)  ali follow..  15  89..................................................LGHATVLV--DLEGVKFVTDPVWADRASFTSFAGPKRYDLDFAVVSHDHYDHLDAVKRITNLNPQIKWFADGSNTVTELNWGESSEFVKNGKTITIWCLPAHSGQGWAVIGENRRFYFPGDT-------------GFCDVEFKKIGEKL---PFDLAAIPIGAYEPREAVEVHKLVRARNSIGIHWGTYPMGTTEYYLEPRDKL 327
16 -11.200[R] COG1237 Metal-dependent hydrolases of the beta-lactamase superfamily II  ali follow..  16  3.....................................RMVVKVTIVFENHAGYRKGLIGYESNGYKVLVDTGTD-GKVLLNNMHELGIDIDVLFITHGHYDHTGGLKEFLKERSEPIEVGYFPDGRKDPVRDDMALIVEGSKGLVVISGCGHS--GIINIARHAMELRGSKIAAL--IGGFHLRGAKKELL-DDVVTNMKELGVN-ALYPGHCTGIEEFSYLWSK............................. 257
17 -10.900[R] COG2220 Predicted Zn-dependent hydrolases of the beta-lactamase fold  ali follow..  15  84..........................PVSPIPVYVIDWNKINSENDSLTWFGHSAFLL--NVDNKQLLIDPMLGPVVSPVSFVGRNRYEIDAVLITHDHYDHLRSIVKLNNKVSHFFVPLGCSAHLIRWGIPEEKITELN--GLTVALTPSHSSGGWVILGNKTRVYTSGDSGYGPHYGPFDIEGAQYDRNWPDLH----MVPEQAIMMLMH------AFTLANHAWNEP........................ 333
18 -10.800[R] COG1782 Predicted metal-dependent RNase, consists of a metallo-beta-lactamase domain and an RNA-binding KH domain  ali follow..  14  187................................................REVGRSCYLL--QTPESRILIDCGVNVSNLSSTPYLYVPEALDAVVITHAHLDHCGLVPLLKFGYRGPIYLTPPTRDLMVLLQLDGVVTDISPDVRLTFYNAGHILGSAIAHFGHYNIAFTGDF------------KFEKTRLFDRAATNFPRL--EALVM---------EATYGGPNDFQPSRKEAEERLIEVINRTLDRGGKVL 408
19 -10.800[R] COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I  ali follow..  13  3.....................LGCAMAFDSDTRSRESNRNFRVKIW-FRKYGGNTICIEVRCGDHVLLFDAGSGLHPAGLALRAEGI-TDVNLFFSHCHYDHIVGFPYFKPFYN-PVPLEICCAKIATRDFKAGDVLDVPGLSIRTGML-NHPGNAIGYRLDWEGLAIITDTLFLYDAMFTDEEMGLYRGYGHSSWQQAIRLAKLANVGFIHHAPSRSDEELDD.............................. 269
20 -9.490[A] KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit)  ali follow..  15  1....................................MTSIIKLKVF-AKDEGPLCYLL--QVDGDYILLDCGWDERLQYFEELKPFIPKISAVLISHPDPLHLGGLPYLVSKCGAPVYATVPVYKMGQMFIYD-DDVDTAFEKVEQVLPAGHMLGGSIWRITGEDIVYCVDHLLITGAHHISLPQMRRKDRDEQLVTKILRTQKGDCMIV-EWMNEKLFKYDSSSARYNPFTLKHVTLCHSHQELMRVRSPKVV 326

FFAS is supported by the NIH grant R01-GM087218-01
1 3 9 8 0 4   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Jaroszewski L, Bierzynski A, Godzik A. Multiple model approach--dealing with alignment ambiguities in protein modeling. Pac Symp Biocomput. 1997;:328-39.