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Query: [O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MENQESDEPMQKKPHLLDSVSPNSMARNSSPSHPIAKSVSFFDCDFSLLCLRLVDYEIDVDATVLQLQNQKLVQQLDLQKKQLYDVESKIQELQLNQTSYDDELISVNQLWNQLVDDLILLGVRAGANQEALNYLDIVDKKRVPPCAADETFLCRLLQVDSLDTSKSDEVVRKVEEALALRHSSTMELMGLFENTIDTQKTKAESISQSLHAVKSTEDATIQLSSINDLMKEESKNLREMIDALHVRHKEHSEQIQAYISSHSTDQSELKHLKGQLEEIKAELEENRRKLITLKMQKDAACEGHVTSPAIANGSLSPEKPVDKTKLRELKDSIDEIKIMAEGRLSELQASQEYNLSLSRQCQDIENELKDDQYIYSSRLYSLINDRIHHWNAELDRYKILTEAIQAERSFVMRRDKELNLRAESLEAANHKTTTVGSRIEVLEKKLQSCIIEKNGLELETEEAIQDSERQDIKSEFIAMASTLSKEMEMMEAQLKRWKDTAQDALYLREQAQSLRVSLSNKADEQKGLEDKCAKQMAEIKSLKALIEKLLKEKLQLQNLASICTRECNDDRGLAEIKDSQRKAQAQAEELKNVLDEHFLELRVKAAHETESACQERLATAKAEIAELRTQLDLSEREVLELKEGIKVKEQEAEASIAEMETIGQAYEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKEFRWLKSAVSSSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNCKNILKCGVCFDRPKEVVIVKCYHLFCQQCIQRSLEIRHRKCPGCGTAFGQNDVRLVKMLast
1 -213.000[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali  100  1MENQESDEPMQKKPHLLDSVSPNSMARNSSPSHPIAKSVSFFDCDFSLLCLRLVDYEIDVDATVLQLQNQKLVQQLDLQKKQLYDVESKIQELQLNQTSYDDELISVNQLWNQLVDDLILLGVRAGANQEALNYLDIVDKKRVPPCAADETFLCRLLQVDSLDTSKSDEVVRKVEEALALRHSSTMELMGLFENTIDTQKTKAESISQSLHAVKSTEDATIQLSSINDLMKEESKNLREMIDALHVRHKEHSEQIQAYISSHSTDQSELKHLKGQLEEIKAELEENRRKLITLKMQKDAACEGHVTSPAIANGSLSPEKPVDKTKLRELKDSIDEIKIMAEGRLSELQASQEYNLSLSRQCQDIENELKDDQYIYSSRLYSLINDRIHHWNAELDRYKILTEAIQAERSFVMRRDKELNLRAESLEAANHKTTTVGSRIEVLEKKLQSCIIEKNGLELETEEAIQDSERQDIKSEFIAMASTLSKEMEMMEAQLKRWKDTAQDALYLREQAQSLRVSLSNKADEQKGLEDKCAKQMAEIKSLKALIEKLLKEKLQLQNLASICTRECNDDRGLAEIKDSQRKAQAQAEELKNVLDEHFLELRVKAAHETESACQERLATAKAEIAELRTQLDLSEREVLELKEGIKVKEQEAEASIAEMETIGQAYEDMQTQNQHLLQQVAERDDYNIKLVSESVKTKHAYNTHLSEKQVMEKQLHQVNASVENFKARIAHNEEQMKGCFSEAYKLIQEDRHLVISLETTKWEVADADKEFRWLKSAVSSSEKEYEQISRRTDDIKLELDDEREKKKLEEELMELNKELEELGSESVEAAIVRLQEEVKNCKNILKCGVCFDRPKEVVIVKCYHLFCQQCIQRSLEIRHRKCPGCGTAFGQNDVRLVKM 899
2 -37.000[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  17  23................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LSPMLEELESAQERIQERIRQLEVIVSRIREREITTTTTPALVSPNEHRDSTAGVIHERSRERLVENGENKTYLIAKALNMEKTSSVP-GGFFDCNICLEKAEDPILTCCGHLFCWGCFYQLPLIYIKECPVCDGEVTDAEVIPIY. 169
3 -33.800[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  14  198..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NRDPDAFIDLCTPEGPRSRTVNLHSNDSLTILPRRSAENDPVVDLDVASPPKRVNRDIDESQKEELYKCPICMDSVREPVSTKCGHVFCRECIETAIRAT-HKCPICNKKLTARQFFRIYL 319
4 -31.100[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  11  23.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ADAPSIVQAHQKDEQIQGLLIMKVTELCKL-NSYPKELSIFAKLL-RRGRTLGEEYVDLTYTNRKGTRLAGRLKMIVFAFAYPLCPYFITKLYKKIMKNNKESKIEDTESVAAFCKGLLDFILDVHMTLFYFKGAFYSISKRIFGMRYVFKHILSKNEANFREETLGSWIYGRKRTNDSITRSSVGLQERSEHESIEGIPKESQLTHINLSDKNQLPFIPEASRKCILCLMNMSDPSCAPCGHLFCWSCLMSWCKERP-ECPLCRQHCQPQEILVLR. 336
5 -30.300[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  30  17...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQP-NCPLCLFEFRESLLRS... 76
6 -30.300[L] KOG0287 Postreplication repair protein RAD18  ali follow..  30  17...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PSLYQLDTLLRCHICKDFLKVPVLTPCGHTFCSLCIRTHLNNQP-NCPLCLFEFRESLLRS... 76
7 -29.100[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  19...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EISASETLDNLIYPALSKIFDYFGLRLDFKLWGSLRIQEELSPLLTWLLQYLYLRKRASSFGESFYGLQRTVTTTGDLLNRRQQFAS-VERKLRTRITRHEDTSPWEQRLLSAFHAFHAAKAAHTFFYLVKYASNHSPIFRLLGLTLRYPSEPPKEDQWTYVVLKMYSNDQRRKVGGTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLSIQTTACSVSGYVFCWKCIVSHMK-EHGTCPVTHYPISLDDLVRIY. 295
8 -28.800[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  10  39......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKKGFKRDDDSGGSSESSNEDMRDNIPIVSGRKKTVRLNRLQRESEQFENSALKDINVEYQSNLSATGESVNTTTVSAINEDTREVILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSNASTVRMNTIIDYQ-QLDREWDSVQEKYKKGAKLEEGMVKNEKKEDIPFVCLICKKDYRSPIATTCGHHFCEQCAITRYR-KTPTCIQCGADTK......... 296
9 -28.500[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  13.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KALKKCIKRFVFELSSLGLSAETISKLMAPTTVDPQQAITLSYSLGKEGHIVVPKIIINVNFDKLKTDKFAASMFKQLNASNMITTVRSNYASNVPSTPSDSTQQPPTNTLPSVSASSQSVETCETVDEDID----------------------TQTMSSDMSEVQSMEISLNCDHEFFEKLTSELQSVEGLQREQRKILFNAIDILSHEISLIASPNSKKKYKSRKIFEIYMDSDIFISCKEADQSHERT----PELAERHLKWFDDQVRLAKCLPSSSKHRDRILYAKFLELNESLLKVASFQQMNKLAVTKIMKKFDKRTSLTAQPLFFQVIESDPLLLVDNASKAICFSLSSKLFSIIPQLRD----FECAICSNVAYKPVRLGCSHVFCLHCLIILQKQKVDFCPLCRAKE.......... 402
10 -28.500[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  15  203.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................AVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQKQIRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLLCTSCADT-LRYQANNCPICRLFP--GPPADPGG 328
11 -28.100[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  12  128..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QDLSSNVQQHHFDI----DRLISNHVERMRMEIEEKRKTQGRRIVEAVEQGLMKTLRAKDDEINHIGKLNLFLEEKVKSLCVENQIWRDVAQSNEATVNALRS-----------------NLQQVLAAVERNRWEEPPTVADDAQSCCGSNDEGDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASVLLLPCRHMLCSVC-----GSSLNTCPICKSPKTAS--LHVNL 333
12 -27.100[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  18  241..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EEAEKVRKRNKAMGVEDEDDEADKDSDEDENALPFACFICREPFVDPVVTKCKHYFCEHCALKHHT-KNKKCFVCNQPTM......... 319
13 -27.000[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  20  253.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKRKQEREEAKIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKEIILLPCGHV-CEDCAQK-----SVTCPVCRGSI--VSKAAAFI 337
14 -26.200[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  18  2........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NASTSSPSQQLQQAINSTIDKECAVCYSEMILPTIPSCGHKFCFICLKGVSVSNNGDCPICRGPIDSQIFKK... 74
15 -26.100[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  20  2.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ECKKCKSNELVMMINECGHPLCKNCVDNIFALNSGNCHVCNRVLRKNNFREQI. 59
16 -26.000[U] KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport  ali follow..  10  157..........................................................................QLKEVLRENDLLRKDVEVKESK----SSSMNSIKTFWSELKKE-RALRKD--------------------------------------EASKITIWKEQYR-VVQEENQHMQMTIQALQDELRIQRDLNQLFQQDSSSRTGEPCVAELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLRERFENAPDSAKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGATEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETLTNQFSDSK---QHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMNKKTKQIQDMAEEKGTQAGEIHDLKDMLRKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQE--EIDNYKKDLKDLKEKVSLLQGDLSEKELKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEKAQAEVDRLLEILKEVENEKNDKDKKIAELESLTSRQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQ-QLQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMA..................................................... 916
17 -25.600[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MPPRRSYPFSGHGGTIARFIEFGEAFGHYGEEEDEEEEDEEEAYVDYGEVQEEDEEEEEEEDSERQTREYIDVLDSPVRVSQNESEGIENQNRRMSNGNKVT----LRDCLVLSVWKAVANTKSGILDSIVFPVDTCMDSTSGFSSDEVEGSLRDVRKIYA 163
18 -24.800[O] COG5540 RING-finger-containing ubiquitin ligase  ali follow..  17  259................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RKFIRTYRTKSKTRRFIEDLPSRTISREGFYSEEEEIENSTQNGELVPLMDESTRRATFGVECVICLESFTDKVALPCKHEFHRPCIAKWIVDYRHACPTCNTEVPPPK...... 370
19 -24.600[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  19  589.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NLEDFEDLKDLEGLTVKQLKEVLMLHRVDYKGCCEKQELLDRVSRLWKTMRE-------------CPAVEKLATDELCKICMDAPIECVFLECGHM-CTSCGKV------NECPICRQYI--VRVVRFFR 699
20 -24.300[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  19  278..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................KGHFKDLPDDLKCPLTGGLLRQPVKTSCNIDFSKEALENALVESDFVCPNCETRILLDSLVP... 342
21 -23.000[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  15  2................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MIKVKKETMRACLSCSICDNILRDA------TTISEKCIYEKITEDEIECPVCNIDLGSTPLEKL.. 61
22 -22.000[R] KOG3002 Zn finger protein  ali follow..  13  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAPGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNGVYELLECPVCTNLMYPPIH-QCGHTLCSSCKLR-----QNTCPTCRYELGNIRCLAL.. 104
23 -21.200[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  24  1..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MDDEGARKVDEKCPLCQANMKLLINPECYHKMCESCVDRIFTTGPAQTPGCNKILRKAKFRE... 70
24 -21.100[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  30  98............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SQCSVCLGDYQP-QIPVCKHTFHMDCIDLWLTS-HTTCPLCRLALIPSR...... 149
25 -21.000[O] KOG0801 Predicted E3 ubiquitin ligase  ali follow..  11  149.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SKSVASDEMEMHFIMCLSKPRLSYNDDVLTK--DAGECVICLEELLDTI-LPCLCIYHKSCIDSWFE-VNRSCPEHP............. 225
26 -20.200[DR] KOG4739 Uncharacterized protein involved in synaptonemal complex formation  ali follow..  21  4............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IQCNHCGIKPNQTYLTACGHVFCQNCTK---AAFNSQCYLCKKPLKVDEINK... 54
27 -19.700[S] KOG3899 Uncharacterized conserved protein  ali follow..  13  141................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ISKALSKYSITPGSYSAVASEIGIEFRQPEIYKKKLISSVIATQNWIIKTTMYNVHFAHQSNTSLSVAKAETYNISHQDQNDTLQMISIIVRPMRQGVSDFHIRINALEFRNLENRVRRPIAIPSNIQLHRNVIDRFVDVFKAQVAQ---------------NPIFPDDATTEKCFACMLNEPNTKIHKQCADFDRNGAPLANGACCSNCY----------CRPMWCVECLARWFAARQSDCPMCRAKFCVLDVSYI.. 386
28 -19.400[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  16  687..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EHGGGTAEHTVDCAICMSDVHSYMVTPCNHVFHTSCLENWMNYKL-QCPVCRSPL.......... 755
29 -19.300[O] KOG4692 Predicted E3 ubiquitin ligase  ali follow..  11  210...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNSVLSQLNWAFSEFILLLQEIQNTAQRQESLMRCLEMVITTAPEI-NRICQLISQVLSRVTVPPGCFQFVVDMCSADLNAVTHYPIVTAALGILLALMQEEMESDLRPQIVTRVSRAFLTDPSFQFATLEFALGEIRTPLLEQKNDPSSRPHIDPLTNDVRVPLPNNSKRIRADPPILKFALNDFPSHVSSEEIDNVRRLIDSLRVKQTLLSDITLPSEDSLCPICCAKPITAVFTPCKHQSCSDCIMQHM-MNSKVCFYCKTTI--QTIETLD. 519
30 -19.100[O] KOG0802 E3 ubiquitin ligase  ali follow..  17  323......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SAILKRIKGYIKLRIALGALHAALPDATSEELRAYDDE--CAICREPMAKAKRLHCNHLFHLGCLRSWLDNEVYSCPTCRKPLFVGR...... 410
31 -19.000[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  17  308......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LALYQSGTSLWKIWRNNKQLDDTLVTVTVEQLQNSAN--ICIICMDELKKPKRLPCGHILHLSCLKNWME-RSQTCPICRLPVFDEK...... 407
32 -18.900[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  27  4............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNCVICAELFGEVFATVCGHMFHHNCLNQWLD-RSKTCPQCRNKCTTRNIFRVYF 60
33 -18.600[O] KOG2164 Predicted E3 ubiquitin ligase  ali follow..  24  209.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FQLAACPFCLEE--AARMSRCGHVYCFSCLLRFVETPTRSCPICWDSIRLRDVHPIRW 286
34 -18.600[O] KOG2879 Predicted E3 ubiquitin ligase  ali follow..  1............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MTPSTPADDAWIRSYQRLLPESQSLLASRRSVIPVAISRVNQFDAARLDVEMSAMLK--EQLVKVFTLMKPGMLFQYEPELDAFLEFLIWRFSIWVDKPTPGNALMNLRYRDERGVVAQHLGKGLEGPGLTSPQK-QYLFSRLQSFSAFRRWGDSEQRPLARRLWTLVQRIEGIYKAASFLNLLSFLYTGRYRNLIEKALKARSPHMNRSVSFEYMNRQLDFLVLFWHSALNLFGDIQEMLLLLLPLLNSSAVKNILSPFAKDKSSSTKEDTVTCPICQVDPAIPLKELTCRRYCYYCIRTRCASAASRCLRCNEPVVAIQ...... 381
35 -18.500[L] COG5627 DNA repair protein MMS21  ali follow..  2..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SEAQLKTSLEALSQNLLPGNQNHCSFDFQLKEIDDSIKQV-------------IKCALVAAEIKNNECLDMLDSGIRELLDAKQRLLLMQQSVDTLANKTSENISDFEVRTTEMTFLLFLLQIFKELIQEYEEKSDYGKYGTQGEYIEFKKTIWHEQNTDGSDFPSMKTFFNVMNTEEQEADEV--MVYSATFDNRCPLTLQPIVHPI-TACNHFYEKDAILSLLN-PTCVCPVCEARLQRSLLK.... 246
36 -18.500[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  16  205................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRRHRLPKSMLKKLPVLRYTKNNANNKYDTCVICLEDFIDKLVLPCSHPYHTHCIDPWLTENRRVCPICKRKVFTKG...... 284
37 -18.100[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  18  469..........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................FQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVCQEC-----APSLRKCPICRGII--KGTVRTFL 617
38 -18.000[R] KOG2979 Protein involved in DNA repair  ali follow..  16  106...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NASLVLVSDNSSTLADIRKAVAMMKNIAVQLEKE-TDKVKDLENSVAELLDLHSDCNHRSTAIQSVANRYQDFKKLLDDEFTKLKATPSSVPQNDHLMRQFREAVWNVHHAGEPMPGDDDEDIVMTST-MTCPLSGTELADPV-MDCRHVYEKSVILHYIVNNPNNCPVCRGKLQNSKVIC... 305
39 -17.900[O] KOG3970 Predicted E3 ubiquitin ligase  ali follow..  15  38...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QSYLTWLTDQDYDPNCSLCKTTLADTIRLNCLHLLHWKCFDEWAANFPARCPCCSQEV.......... 104
40 -17.700[U] KOG0946 ER-Golgi vesicle-tethering protein p115  ali follow..  12  562........................................................................................................................................................................................................................................................................................................................................................EKLKQLIEKRIGKENFIEKL-------GFISKHELYSRASQKPQPNFPSTKLVKELEGVITKAIYKSSEEDKKEEEVKKTLEQHDNIVTHYKNMIREQDLQLEELRQQVSTLKCQNEQLQTA------VTQQVSQIQQHKDQYNLLKIQLGKDNQHQGSYSEGAQMNGIQPEEIGRLREEIEELKRNQELLQSQLTEKDSMIENMKSSQTSGTNEQSS-----------------------------------------------------------------AIVSARDSEQVAELKQELATLKSQLNSQSVEITKLQTEKQELLQKTEAFAKSVEVQGETETIIATKTTDVEGRLSALLQETKELKNEIKALSEERTAIKEQLDSSNSTIAILQTEKDKLELEITDSKKEQDDLLVLLADQDQKILSLKNKLKDLGHPVEEEDELESGDQEDEDDESEDPGKDLD........................................................................................ 960
41 -16.700[O] KOG3268 Predicted E3 ubiquitin ligase  ali follow..  11  52...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RLLCSWQLRTILSGYHRIVQQRMQHPPDLMSFMMELKMLLEVALKNRQELYALPPPPQSLIEEIGTLG-KLKAEDASGREHLITLKLKAKYPAESPDYFVDFPVPFCASWTPQSSLISIYSQFLAAIESLKDVMDEIDEKTWVLEPEKPPRSATARRIALGNNVSINIEVDPRHPTMLPECFFLGADHVVKPLGIKLSRNIHLWDPENSVLQNLKDVLEIDFPARAILEKSDFTMD---------------CGICYAYQLDGTISQCGQPFHQICLYEWLRGLLTECPYCSKPITLK....... 369
42 -16.700[O] KOG1814 Predicted E3 ubiquitin ligase  ali follow..  12  3...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EVEVESDNKHLVADELIALQSIYPEIHLDGNNY-----------------------RLNIPVNTESDYFLSFKSPDESTLTDTIVVRHFPD----------VMEFFLPEAYPFNSPPTFFLKSSWLPLKQKRVLTSSLIKLWNEIHDCV-DAIEHVRSIATIAFHLPTEMVFPGGFDDLKKEILAFDKNAKLLEFQ--IRKFQCNVCFDEFNGT-LTRCGHVSCQSCLRDYYTMCIQKCIDCGKDAPVLTLKEL.. 236
43 -16.600[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  18  421....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HSTTRRNSNSPPSPSSMNQRRLGPREVGGQGAGNTGGLEPVHPASLPDSSLATSAPLCCTLCHERLEDTHFVQCSHKFCFPCSRQSIKQQ-EKCPLVGSAFMQGEIATI-L 548
44 -16.300[O] KOG4159 Predicted E3 ubiquitin ligase  ali follow..  34  6.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EPVTTPCGHSFCKNCLERCLD-HAPYCPLCKESLKE........ 40
45 -16.300[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  16............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EVDSDTSIFQLKEVVAKRQGVPADQLRVIFAGKELRNDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSPPAGSPAGRSIYNS----------------FYVYCKGPCQRVQPGKLRVQCSTCRQATLTLTQEFFFKCGAHPTSDKETPVALHLIATNSRNITCITCTDVRSPVLVCNSRHVICLDCFHLYCVTRLNDCVAPNSLIKELHHFRI.. 278
46 -15.900[DO] KOG1493 Anaphase-promoting complex (APC), subunit 11  ali follow..  14  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EQQIQMDEQENDESQGNDDQQNMSMSSSELHTMQDDHPGILLKTNTRMSITVKKLHVCGTCGICRMEFESAVLGICRHAFHRHCIDKWIAAPTNQCPLCRQDWTIVE...... 135
47 -15.900[O] KOG2817 Predicted E3 ubiquitin ligase  ali follow..  10  12............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TAPGNKCLAKLNELESILKDAKKSCLKDPTTSMKELVACEKTQQVFDDLKRTEKKFHTSLNRFGKTLEKKFNFDLEDIKLHSSFESKKREIDTLLKSIVQGIRDLKLPIEWASQCRGYLERKGSSLEYTLQKYRSNYLTTKDIMAAIRYCRTNMAEFQKKHLADIQKTMIALFFCSRNEVLSGTNDSHDSIHHIISNNAQLNIPQEYIDVLDLDWKSLELFHSVFTCPVSKEQATEPMMMSCGHVIVKESLRQLSRNGSQKCPYCPNENVAADAIRVYF 398
48 -15.900[R] COG5109 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  10  12............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TAPGNKCLAKLNELESILKDAKKSCLKDPTTSMKELVACEKTQQVFDDLKRTEKKFHTSLNRFGKTLEKKFNFDLEDIKLHSSFESKKREIDTLLKSIVQGIRDLKLPIEWASQCRGYLERKGSSLEYTLQKYRSNYLTTKDIMAAIRYCRTNMAEFQKKHLADIQKTMIALFFCSRNEVLSGTNDSHDSIHHIISNNAQLNIPQEYIDVLDLDWKSLELFHSVFTCPVSKEQATEPMMMSCGHVIVKESLRQLSRNGSQKCPYCPNENVAADAIRVYF 398
49 -15.800[S] KOG4638 Uncharacterized conserved protein  ali follow..  14  342................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TALKALSRKEVHYGSYATTEQATCVPSA--RRRCTPQFFAKIAFQSGEVFLHIAIIFVYEDVER................... 412
50 -15.800[S] COG1511 Predicted membrane protein  ali follow..  41...................................................DPYGTVDQLPVVVVNQDKDDLVKELKDNNHFSNDLDQSLKDLLNQK-----LVVEIPEDFSKNASTV--LKYHTNAGSNYVGATIGEKAIDKLKASVSKEVTEQYTKV-------IFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATISDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLAGLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETAMKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQ-----INSVEKKLPQVDAPDFDQILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEGADKIYNGSQKLTDGQTKTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSKQVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPVKTKDD....................................................................................................................................................................................................................................................................................................................................... 571
51 -15.700[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  12  303........................................................................................................................................................................................................................................................................................................................................................................................................................................................................PYGPEDGIRWRLKYKLYDEALDMAKHNADLLSKTDLSPKKVGRMIIEGYLTGKRARAAASRLPLICGECKEEWEWAVNQFEEVKLCTLLAEVLPDGTPTLDPECDLYMTSFIIDRTQWRIQQISKSGNLADVDETERVLMDALAHLYLYERKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQITELMNINSERALRLLLD-SFVMEKIGRQPKLQLAYLTKLMSRNDKAVQLYAEYDQKKLLPFLRKNANYNVNKARKLCSDKIEETIYLLAKSGNHYDAVKMMVREYRNMEKVIDYCKDQNDPDLGVVAEFPAHFSQLIIEASNCLDPLLSDIPNLSEALDKLLVDYTNHAELQQCCYDSTLNDLNVLTQGLISAADESVSVNIVSRCSLCAQIISDIKVFKCGHIFHLACSTSEMSIEEGLCIACSDQIELINV..... 807
52 -15.700[S] COG4372 Uncharacterized protein conserved in bacteria with the myosin-like domain  ali follow..  12  40..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................RPRQTAVLLTVITGTLISASTLGILFTFSKSLREGVFQLDDILAQLRVAKTELEQASQAKEEIESELTAVREEQQLVQERSRELNRNYTKALQLLRRVSEQSRNLRQEVANLSAERAQLNEQKDSLLAESSELQSQVKLRDQELSKRQERIAQQEKVLARQREQVQSLEKRFASLEAQRQQLQAEINQRDTKIDQLDQAIAAKDNDIQAREEKLQGLETELSFLQREVEELERYYQDYQELRG.............................................................................. 282
53 -15.200[O] KOG1039 Predicted E3 ubiquitin ligase  ali follow..  14  205.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DPEQRKAHEKICMLTFEHEMEKAFAFQASQDKVCSICMEVILEKILSNCNHTYCLSCIRQWRCAKQKSCPECRVI-KKNELIEAF. 318
54 -15.100[T] KOG0297 TNF receptor-associated factor  ali follow..  16  25.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEE...... 80
55 -15.100[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  1...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MSQKNFFDEG-KSYGVNDYAGFHFENGADSSLPQVSAQGVVRETDSSNFDASPVASGSGISDVGPFGADFHQLQQHVQTPYGGMTMPASSSSGATSVPPEQDPSLSVSFNRLPKSASTKTKNGRIRSSRREDDNRIPFYDLDVAEGAEDDLQEDFHVEGMKTKSGRKIQRPVNPNATALKRKSRKVDMVTLCSVCQRPLSNRIV--CYHQLCHH--DATVQDVDAECMKCQYR........... 246
56 -14.900[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  205............................................................................................................................................................................................................................................................................................................................................................YQDPEVAQIIRKLDERKREAVQKERYDYAKKLKQAIADLQKVGERLGRYEDLAKEKKQQMEQYRAEVYEQLELHSLLDAELMRRPFDLPLQPLARSGSPCHQKPMPSLPQLEERGTENQFAEPFLQEKPSSYSLTISPQHSAVDPLLPATDPHPKINAESLPYDERPLPAIRKHYGEAVVEPEMSNADISDARRGGMLGEPEPLTEKALREASSAIDVLGETLVAEAYCKTWSYREDALLALSKKLMEMPVGTPKEDLKNTLRASVFLVRRKDIVTSVFQASLKLLKMIITQYIPKHKLSKLETAHCVERLTRTGDSSARLRVTAANFIQEMALFKEVIPSYLVQPLKANSSVHLAMSQMGLLARLLKDIDNVMKFSVSALEHRVYEVRETAVRINILYKTIFEGFAKIDGRATDAEMRARRKAATEEAEKQKKEEIKALQGQLAALKEIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLD-KHCLMLTRCDHCKQSLTEHLLTEC-DGFCYRCLPRHIKHKDNRCPLCHENFSPGE--KAHL 863
57 -14.600[OD] COG5194 Component of SCF ubiquitin ligase and anaphase-promoting complex  ali follow..  14  2..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SNEVDRMDVDEDESQNIAQSSNQSAPVETKKKRFEIKKWTAV-NCAICRNHIMEAAWGVCNHAFHLHCINKWIKTRD-ACPLDNQPWQLARCGR... 121
58 -14.600[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  14  1.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................MQNGKPRSSARPSFHRRPKDGVANTTTDNAAVKPEALESYTGNDDNA--------CVVCFKNVEIFSIGDCDHPVCYECTRMRVLCQQNECPICR-----HVLSKVLF 96
59 -14.500[O] KOG4172 Predicted E3 ubiquitin ligase  ali follow..  26  1...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................NGAQEVNEGDECTICMDAPVNSVLYTCGHMMCFECGRR-LLTTKGTCPICRAPV--QDVIKTY. 61
60 -14.400[O] KOG1734 Predicted RING-containing E3 ubiquitin ligase  ali follow..  271.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................TARMASRIGYYTPEGLPKKHLEDGVCAVCGGRLSEHVHDADAVVTTKMVEDLYKLSCGHVFHEFCIRGWVVVKLQTCPYCKERVDLQRMFK... 368
61 -14.300[S] COG4717 Uncharacterized conserved protein  ali follow..  156.............................................................................................................................................................................................EAVSKLDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAG-YHQLLEEKRTLEARLAAAETELKETAGHIRMIEGERKPLLNEKATLEQVIAEFPEHAGQ-------------------PADGLHQLEKYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGEQLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNYEWQLQQAVQQYVQARDRKRQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDET-QGQHQEQAKLREQLTFFERQQAKQKKTVIAAGMAALIVYWLVSGKSSSRNSRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWEAEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRRTFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLELEQEIQYFHAQIEQLFAAAAAISRQLKDTENKLHHVNAQLQGGYPEELELADSNTELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQTEMQKERVKETAKK-VKQVIRNKLERHK---------KIELPRLLETAGEFF-----DDSIMVMHRD-----EELSQGTCEQLYT 891
62 -14.200[R] KOG1819 FYVE finger-containing proteins  ali follow..  10.........................................................................................................................................................................................................................................................................................................................................KPRPDDWMPLADSALNDVTRLRVAQDRVLHIITEMLIHLYPREQDRACRDFRVLHDTLP-FGAECLSAGSNIIDHETESDLIRPLAKDVTKQLDFLRDLLKNQSLRDPSAYNPVIKENLLKFDKLFAEFEYQ-PVKSVKEHDSQLDVAVLFSEVLSTQDLIDYCDPSVMIAIPRLGIVWGLLVYSNGALNVDVPAENLSEMFRPFYSLLVKIRNLLRILTPTELTKLETVLCKGESAVPEDTSSTLTMSDFRTNATDEEKAKNNQRVWMCDMPSDSTSSLDSSVQDSSSETTSLASSALASPHSGSEENVSQIENEEGDDEAIGTNSNSSNEVTESPETIEEPDNVDMEESSESEVDTHIDETRNESDDEITDDVQASDVLQVETKKCKSSRLLEQKKFDKSVKTIIPMQTDPRSQIDPK--NLRSRFRSSEDLVHRLFVCIAGVADQLQNYSSEIRKVLKLILQPSEIIPVYEVVNAQVANSQTEGEETGVEAQETLPLPAFMGVRWVPD-EDCEQCTACSMPFRRHHCRNCGRIFCHKCSCNTISIPEVVSSPQ.............. 621
63 -13.800[K] KOG1244 Predicted transcription factor Requiem/NEURO-D4  ali follow..  21  330..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CNICGTSENDDQLLFCYHMY---CLTPSMSEPPESCHLCLD............ 376
64 -13.800[R] KOG4299 PHD Zn-finger protein  ali follow..  2.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DAKPWNHTSEAFQASILEDLKIIQKAGAERNAKSSHGSINSRSASPNKATSRRNRAQNGNSNGRASVDNSDDGSKDDLDYSPSVKRKHVNGEGAEKGDHDTSNNGPSITKLRRKVRRTYDTKDGFVAWNTLDDDFRPIVPDQERSRKINPQKGNNNNLLKENKSLKTTAKDLSDISSSSMKKANNSSKPLFSGKLTFKANIPVPTSEVVTENNVTRNVTVYSNQKHLGNESENFNDMEGRAEDISSNELLPTPEEYPYRYNN---CSACHGP-----FLCCFHF---TCIDPPIEEKN--CNEC.............. 309
65 -13.600[O] KOG2930 SCF ubiquitin ligase, Rbx1 component  ali follow..  24  54............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................IECQANQASATSVAWGVCNHAFHFHCISRWLKTRQ-VCPLDNREWDFQKY..... 106
66 -13.600[U] KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11  ali follow..  329.........................................................................................................................................................................................................................................................................................................................................KDMESKLDMLFKKNLYTVANLVQSQHADAAATANVMRK----DHLYGKQDFDEAMLQYINTIGYLEPSFVIQKFLDAQRIYNLTNYLEKLHEKGLASKDHTTLL-TKLKDVEKLNTFIRKEDGIGELKFDVETAIRVCRAANYHEHAMYVAKKAGKHEWYLKILLEDLGNYDEALQYVSSLEPSQAGVTIEQYGKKETIDILMRLCTEQGIPNGVFLSMLPSPVDFITVFVQHPHSLMHFLERYAEIVQDSPAQAEINNTLLELYLSRDLNFPSISLSENGLDKDLIDHSVAAAVSKADPEKKTNADSKDAMEKDCTERQQKGLELLKMAWPSDLEQPLYDVDLAVILCEMNSFKDGLLYLYEKMKFYKEVIACYMQNHD------------HEGLIACCKRLGDSSKGGDPSL------ADLLKYFGEIGEDCTKEVKEVLTYIER--DDILPPIIVLQTLAKNPCLTLSVIKDYIARKLEQESKIIEEDRRAVEKYQETTKNMRKEIEDLRT--KCTACTFTLDIPAV-MCMHSFHQRCLGD----NEKECPECAPE........... 880
67 -13.400[B] KOG1973 Chromatin remodeling protein, contains PHD Zn-finger  ali follow..  7...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LENYLDGKKILKHGKHSKTYIIHDLQTGLESLPTELERNFKLMRKLDDRAQTAMKSIDSHAKDFMRKLGENGAMSED-----ERRERQEDIKALFGKAKEYSDDKVQLAIQTYELVDKQIRRLDNDLARFEGEIQEKASSTRAKSEEVVAKSKTVPKYLFFHKLTPSFDSKKSKVNQEKETRKGGAQKKTVEVDDSEKESCHTAATHPSDVMDMPVDPNEPTYC-LCHQVSYGEMIG-CDNPDCPACVGLTTKPKGK-CPKCTQDRKKK....... 328
68 -13.400[S] KOG4445 Uncharacterized conserved protein, contains RWD domain  ali follow..  27  106.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QCVVCLYGFADFTRTECFHYLHSYCLARHLNALRRLCPVCREHIGDET...... 178
69 -13.300[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  20  112..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................GVGNGALNNYTFCNYC-SKPKSP---RTHHC-CGMCVLDM----DHHCPNC---VGAGNHKYFIA 169
70 -13.300[R] KOG2789 Putative Zn-finger protein  ali follow..  15  39............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PAYKTNIVRKL--LERRLMPFYKGLDSYSKDWPA-DKVVEVVEKALGPHKSALLHCAIRQSRSLSVGNTRSLKRDSRGSSDHLLTRNRSNSTPGSISADYRTTAITTIYANAMECPICFLYYPSNF-TRC-QPICSECFEFDLISEPAKCPYCMTEFG......... 218
71 -13.200[S] COG4913 Uncharacterized protein conserved in bacteria  ali follow..  226........................................................................................................................................................LTDFVCSHMLEPCDVGSRIEALICHFDDTAKQQVKLLVPLVDDVQKHQTQLASIQADTLRPYFAQLKGELLKHRLDALAAEAAQLTVEIQHLEEQRKAADSEVTQLRQALRDNGDRLEELAAEIEQLEQAKAQRQKKSDRYQTLLTKIDLTQQQRFAQHTEELNAAIERLHNDKSEKDRALYDAREKHTTLLAEINSLQQRQSNISAAQIRIRHDLCMA---EDARNWEAAERLLHGFGLTLLVPDAHYKAVATWVNNQQLQGRLVYFHMRPRNTTQEAALHAQALVHKLIITIEQFHCEARAITQA-GRHEKDDRHRIDDRSRYVLGWSNADKLHTLNAQRQHLEDSMGMLGQDIGTIQRECQKQQERLDALNKLGEYPEFADIDWMSLVRQIAGRKKEQEQLQATSNILQTLQQQLTAAQTQVSVLERKCKNAWHEQGEVKS-QQKTAQQMWNQARSVWDDAPLSQAQITLLAGWRQQALGEHVLSVESCDNHEQQVRQWLQKRIDAENAHLRQLNDRITGAMHRFKNQFKAETVEMDADLAALPEYARMLNQKDDLPRFEARFKALLNVIASFNAQLNRERETITERIKDINQSLHGIDYNQDRYINQSLHGIDSQKGRYITLPSPDAEIRDFQQDLRACTEGTLTGSDDEQYSDAKFLQVKRIIDRFRGREGLSDADRRAKVTDVRNWFVFSASERWRADVLAASLAYQF-------GLKWDEVRSESFREAFGRGS...... 1071
72 -13.200[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  14  111.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DSKDHKSGSTEEYPYDYLLYYPAIKCSTCR--VKPARSKHCS--ICNRCVLV-----DHHCINC---IGKGNYLQFYL 181
73 -13.200[D] COG3096 Uncharacterized protein involved in chromosome partitioning  ali follow..  267......................................................TNYVAADYMRHANERRVHLDKALEFRRELHTSRQQLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDELQIRL----------EQNEVVAEAIERQQENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAIAALNRAKELCHLPDLTADCAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLADFCKRQGKNFDIDEEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQRAPVWLAAQNTEYLQQLLEREREAIVERDEVGARKNAVDEEIERLSQPGGSEDQRLNADDVSLEDAPYFSALYTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQW-AARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPE----AEIRQLNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRERLDEAQEAARQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFALTEVVQRRAH--SDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQVLASLKSSYDTKKELLNDLQRELQDISGAEERARIRRDELHAQLSNNRSRRNQLEKALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKA........................................................................................ 1115
74 -13.100[S] KOG0396 Uncharacterized conserved protein  ali follow..  8...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EHATLKVPYEMLNKRFRSAQKIIDREVDQVINVSRQVEKALEAEEGPILAEVTKLVDNVAQKLQVLKRKAEESINDELSVTQICKRKLDHLKGI-PSSVTGDLWQGSVDQWKRIRLDRLVIEHLLRMGYYETAEELAAKSDVRHLTNLDIFQTSREVEDDLASHSTKCVLWCIDNKSKLRKINSTIERQNQRFEAVKHSRRYFPAYEKTQLNEICHVMALLSVFSAAVQAGLSALKTPHCYAQTCRNLNCPVCQEDLNRIALKLPYSHCVQSRLICRVTGLPLNEPMMLPNGQIFGQMALPDITKDDGTTCPVTNTKFSNPKVEKVFV 393
75 -13.000[B] COG5034 Chromatin remodeling protein, contains PhD zinc finger  ali follow..  12...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................LNDFTDAIVSVPESVCGKFTSLKEIDAQVRDIRQNVIQEIGVVKNDELSGEERCERLQKTLKEILPYSDSKICATDAMNNIKSCIDRLDAGFEYVELEIRALMNYHSTVTPQTSERRRETRRHQNNQHSQQYSSQERSSSYNNFEDASSPQSSYHTPTKRRKNAVPRKSSSPPLSSTKHAPQSTERRPVRRSESRLKQTNGEPLVKHDTLDSSDISREGEQLYC-YCQQVSYGQMIG-CDNENCKPCVGLVEPPKGI-CKECEELAKSS....... 301

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.