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Query: [F] KOG1112 Ribonucleotide reductase, alpha subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MQRYNSTYVVKRDGRKEDVHFDKITSRIQKLSYGLNMDFVDPVAVAIKVISGLYKGVTTVELDNLAAETAASMTTQHPEYALLAARIAVSNLHKKTNKVFSEVMKTLHEFHHPHTGKHAPMISDETWAIIEKNADKLNSAIVYDRDYSYTYFGFKTLERSYLLKINKEIVERPQQMLMRVSIGIHGDDITSAIETYNLMSERYMTHASPTLFNSGTCRPQMSSCFLLTMSEDSILGIYDTLKQCALISKSAGGIGLNVHKIRATGSVIAGTNGTSNGLIPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHADIFEFVSLRKNTGPEEERARDLFLALWIPDLFMKRVEKDQEWSLMCPCECPGLDDCWGEEFEALYAKYEAEGRVRKTVKARKLWEHIVSNQIETGLPYITYKDAANRKSNQQNLGTIKCSNLCTEIIEYSAPDEIAVCNLASIALNRYVTPEKKFDFVKLAEVTKVITRNLNKIIDVNYYPVEEARNSNMRHRPIGLGVQGLADCFMLMRYPFTSAEARDLNKRIFETIYYAALEASCELAELNGPYSTYEGSPVSKGQLQFDMWGVTPTDQCDWATLRKKIAKHGIRNSLLMAPMPTASTAQILGNNESIEPYTSNIYSRRVLSGDFQIVNPHMLKDLVERGLWTDEMKNRLIANNGSIQNIDGIPSDIKELYRTVWEISQKDIIEMAADRGAYIDQSQSLNIHMAKPSYAGITSMHFYGWKKGLKTGMYYLRTKPAVNAVQFTVDKNALKTNQQAETPATVAESQDEGCLMCSGLast
1 -225.000[F] KOG1112 Ribonucleotide reductase, alpha subunit  ali  100  1MQRYNSTYVVKRDGRKEDVHFDKITSRIQKLSYGLNMDFVDPVAVAIKVISGLYKGVTTVELDNLAAETAASMTTQHPEYALLAARIAVSNLHKKTNKVFSEVMKTLHEFHHPHTGKHAPMISDETWAIIEKNADKLNSAIVYDRDYSYTYFGFKTLERSYLLKINKEIVERPQQMLMRVSIGIHGDDITSAIETYNLMSERYMTHASPTLFNSGTCRPQMSSCFLLTMSEDSILGIYDTLKQCALISKSAGGIGLNVHKIRATGSVIAGTNGTSNGLIPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHADIFEFVSLRKNTGPEEERARDLFLALWIPDLFMKRVEKDQEWSLMCPCECPGLDDCWGEEFEALYAKYEAEGRVRKTVKARKLWEHIVSNQIETGLPYITYKDAANRKSNQQNLGTIKCSNLCTEIIEYSAPDEIAVCNLASIALNRYVTPEKKFDFVKLAEVTKVITRNLNKIIDVNYYPVEEARNSNMRHRPIGLGVQGLADCFMLMRYPFTSAEARDLNKRIFETIYYAALEASCELAELNGPYSTYEGSPVSKGQLQFDMWGVTPTDQCDWATLRKKIAKHGIRNSLLMAPMPTASTAQILGNNESIEPYTSNIYSRRVLSGDFQIVNPHMLKDLVERGLWTDEMKNRLIANNGSIQNIDGIPSDIKELYRTVWEISQKDIIEMAADRGAYIDQSQSLNIHMAKPSYAGITSMHFYGWKKGLKTGMYYLRTKPAVNAVQFTVDKNALKTNQQAETPATVAESQDEGCLMCSG 788
2 -170.000[F] COG0209 Ribonucleotide reductase, alpha subunit  ali follow..  22  1...............MDTPDTSLIREREAEAVQGA----PEPVAMTAGKPAKSSDGLDYHALNAMLNLYDED-GKIQLDCDRQAARQYFLQHVNQNTVFFHN-----LREKLDYLVAEGYYEQTVLDQYSFNFVRDLFDEAYARKFRFPTFLGAFKYYTSYTLKTFKRYLERYEDRVCMVALTLARGDEQLARDLVEEIISGRYQPATPTFLNAGKKRGELVSCFLLRV-EDNMESIGRSINSALQLSKRGGGVALCLTNLREAGAPIKQIENQSSGIIPVMKLLEDSFSYANQLG-ARQGAGAVYLHAHHPDIMRFLDTKRENADEKIRIKTLSLGVVIPDITFELARNNEDMYLFSPYDVQRVYGVPLTEISKYREMVNDAQIAKKKINAREFFQVLAEIQFESGYPYIMFEDTVNRANPIDG--RITMSNLCSEILQVSEASLDISCNLGSLNIAAA------MDAPDFGKTIETSIRALTAVSDMSHICVPSVARGNAESHAIGLGQMNLHGYLARERIFYGSEEGVDFTNIYFYTVAYHAVRASNRIAVETGKFKGFEKSKYASGEYFDKYTDQAIPTQDDWCALKKAVMEGGLYNQNLQAVPPTGSISYINHSTSSIHPIVSKIEIRKEGKIG------------------------------RVYYPAAFMTNDNLEYYQDAYEIGPEKIIDTYAAATQHVDQGLSLTLFFRTATTRDINRAQIYAWKKGIKTIYYIRLRQMALEGTQV------------------------QGCVSCA. 737
3 -21.000[F] COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase  ali follow..  11  3......PIVIKRDGSKAPFNRDRIQAAVESAAEHADQEIAIALNVALAVELKLRDYVHITEIQTLVENELMQGPYKALARSYIEYRHDRDVAREKQSKLTKEIEGLIQESNADLLNENANKDGKVIPTQRDLLAGIVAKHYAKTR----------------------------------LPRDVVQAHESGDIHYHDL-----------------APFFPMFNC-----------------------------MLIDLKGMLTHG--FKMGNAEIDTPKSISTATAVTAQIIAQVASHIYGGTT--INRIDEVLAPYVTASYEKHLEIARYDAFQSLEYEVNTLHTANGQTPFVTFGFGLGTSWESRLIQQSILKNRIAGLGKNRKTAVFPKYDIKQLALECASKRMYPDILNYDKVVEVTGSFKTPMGCRSFLNPYEENGELIHEGRNNLVVSLNLPRIALQAKGDIYALLDDKLKLARRALENVKARVAPILSIADIFKHGRASISLGYIGVHETIMAL---YDDVQLREEAVKIIQHLRNAVEQWK---------------------------------------------KETGYAFS--LYGTPSENLC--------------------------------------------SRFCRIDAKQFGVVEGVTD-----KGYYTNSFKVNPYDKIDFEMPYPEISSGGFICYGEFPNMQRNV--EALENVWDYSYHRVPYYGTNTPIDECYECGFTGEFDCTSKGFVC---------PRCGNHEP 670
4 -9.480[K] COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains  ali follow..  19  47....VLPRVIKSDEVREPFNEEKLRRGMLKALEKRPVSSDDVETAISHIKSQLRAEVPTKMVGNLVMEALKRL--DKVAYIRFAS............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 129
5 -7.630[C] COG1882 Pyruvate-formate lyase  ali follow..  8  235.............................................................................................................................................................................LLQIQEMAAKYGFDISRPAQNAQEAVQWLYFAYQNGGAMSLGRTASFLDIYI----ERDFKAGVLNEQQAQELIDHF----------------KIRMVRFLRTPEFDSLFSGDPIWATEVIGGMGLDGRTLV-------KNS-YLHTLHTMGPAPEPNLTILWSEELPIAFKKYAAQ---------------------------------------------------SIVTSSLQYENDDLMRTDFNSDDY-----AIACCVSPMVIGKQMQFFGARANLAKTLLYAINGGV-DVLDYDKVMDSLDHFMDWLAVQY--ASLMALHDRDVYRTMACGLSVATDSLSAIK-QYGNND--ERVDSIACDLVERFMKKIKALPTYRNAVPTQSILTITSNVVYGQKTGNTPDGRRAGTPFAPGANMHGRDRKGAVASLTSVAKLPFTYAKDGIVPAALGKEDPVRKTNLVGLLDGYFHHEADVEGGQHLNV----VMNREMLLDAIEHPEKYPNL-----------TIRVSGYAVRFNALTREQQQDVISRTFTQ............................................................... 762
6 -7.300[C] COG1151 6Fe-6S prismane cluster-containing protein  ali follow..  9  77.............GIGP--DAMAMRNFLLKNIMGAGTYSHHAYEAYRTLKATAEGRTPENKLKWMCEKLGIDTAQSINDMAFELAVILEDQQRIGVEDQNVMVEAFAPKKRIEAWKKLGIYPAGTVHEEQN-------------------------CVASCLTNVDGSHIS-----LAMKALRLGIATIYNTQIGLEMVQDILFGTPTPHEVNMDLGIMDPEYVNIVFNGHQIGAATILKAKEIQDMAKQAGAKGLRVVFVGHMGNWLAIEPLLATGTVDIFAMEENCSPPAIDMYAEKYQVTLAAVS----TIIDLPGVNYKFPYDPAQADET--AQRLIELGIENFKKRKERQIKPHVPQKIQKAIAGFSTEAVLGALGNKDPLVDVIAKGQIKGVVALANCSTLRNGPQDWVTINLTKELIKRDILVVSGGCGNHALEVAGGNGLKAVCNALKIPPVLSFGTCTDTGRISMLVTALAEHLN--VDVPQLPIAVTAPEWMEQKATIDGIYGAYTHLSPTPFMTGARQLVDLLTNKAEDVTGGKIALGDDPMK.......................................................................................................................................................................................................................................... 620
7 -6.610[J] KOG0188 Alanyl-tRNA synthetase  ali follow..  12  18.....................................................................................................................................................................................................................KEQKHIYVHSSSTIPLDDPTL------------LFANAG--------MNQFKPIFLGTADPNSEMSKWVRVANTQ-KCIRAGGK-------------HNDLDDFFEM----------LGNWSFG----DYFKKEICS--AWEF--------LTQRLALPKDRLYVTYDAASGLEPDLECKQMWLDL-------GLK------PGSMKDNFWEMGETGPCGPCSELHFDRIGGRSVPELVNM-------------DDPDVLEIWNLVFIQYNRESDGSLKQLPKKHIDC------GMGFERLVSVIQNKRSNYDTDLFVPLFDAIYRVLADHARTITIALAD--GGTPDNTGRGYVLRRILR-------------RAVRYATEKLNAKPGFFATLVNTVVDLLVKKDPQHIIDIINEQFLKTLTRG--RNLLNRTIEKLGNQTTIPGDVAWRLYDTYGFPVDLTQLMAEEKSLYEAAKHNSYVLSQGKGASKIEEINLDVHAISQLQEQGVPPTNDTFKYKYEAVSDERDSYNYGVCNSKIVALRFENQFVNEITSGQK................. 526
8 -6.530[T] KOG0604 MAP kinase-activated protein kinase 2  ali follow..  14  65..............................................................................................................................................................................................................................................YPVTQDYRISRKVLGVGIN--------GKVVECEHRQSGDKFALKV-------LRDTQKARREVELHVMASGHGHVVSVHDVYKNSYNGVDCLLVVMENMKGGELFNRIQERGQ--------------------------------KAFTEREAAGIVNEICSAVAHLHRMSIAHRD-------------LKPENL-----LYVTTASNAALKLTDFGFAKKTDESEP--------------QGLKTACFTPYYCAPEVLGTEKYDKSCDLWSIGVIMYILLCGYPFYSQHGQPMSPGMKAKIKSGQYTAAKDLIRKTEPTERITIEQTMEHKWISHYRRVPDTPLFTSSNLNDQREQWTDMQDEMEATLASMRVGPENIQIKSLGDSNNKLLAKRRKGGASPKDDPMDDIKEEEKDDEEEKMIS............................................................................................................................. 425
9 -6.450[L] COG1074 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains)  ali follow..  9  1MNIPKPADSTWTDDQWNAIV-STGQDILVAAAAGSGKTAV----LVERMIRKITAEENPIDVDRLLVVT----------FTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLNRASI--STLHSFCLQVLKKYYYLIDLDPGFRIDQTEGELIGDEVLDELFEDEYAKGEKAFFELVDRYTTDRQFLVKQVYEYSRSHAWLESFVHLYDVSEKSAIEELPFVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSELYKRVKLLEKLKTDYFTRSPEQHLKSLAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAENDKGEREPSEAARFYQEQFHEVLVDEYQDTNLVQESILQLVTSDVKQSIYR--FRLAEPLL-FLSKYKRKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQAELKIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSPFKVYDGKKKTHRNIQYRAPQIMEELRAQGIPVYANLTSGY----FEAVEVAVALSVLKVI----------------------------------DNPYQDIPLASVLRSPIVGADENELSLIRLENKKA--PYYEAMKDYLAAGDRSDELYQKLNTFYGHLQKWRAELIWEVYRDTKYMDYVGGMPANLRVLYDRARQYESTAFRGLFRFLR-FIERMQERGDDLGTARGEDVVRLMTIHSSKGLEFPVVFVAG......................................... 808
10 -6.250[U] KOG2148 Exocyst protein Sec3  ali follow..  8  184...................NAEAFAEKLSRELQVLDGANIQSIMASEKQVNILMKLLDVDQIELKLSSYEEMLQSVKEQMDQISESNHLIHLSNTNNVKLLSEIELLVNHMDLAKGHIKALQEGDLAS-CTNAADALLQCMNVALRPGHDLLLA-------VKQQQQRFSDLRELFARRLASHLNNVFVQQGHDQSSTLAQHSVELTLPNHHPFHRDLLRYAKLWLKSTDYGKYEGLTKNYMDYLEIKDFFEVAKIKMTGTTKESKKFATLPRKESAVKQETESLHGSSGKLTGSTSSLNKLSVQSSGNRRSQSSSLLDMGNMSASDLDVADRTKFDKIFESELEPLCLAEQDFKLQQHQSMPGTMAEAEDLDGGTLSRQHNCGTPLPVSSEKDMIRQMMIKIFRCIEPELNLIALGDKIDSFNSLYMLVKMSHHVWTAQNVDPASFLS--------------------TTLGNVLVTVKRNFDKCISNQIRQMEEVKISKKSKVGILPFVAEFEEFAGLAESIFKNAERRGDLDKAYTKLIRGVFVNVEKVANESQKTPRMENFHHIFATLSRLKISCLEAEKKEAKQKYTDHLQSYVIYSL------GQPLEKLNHFFEGVEARVAQGIREEEVSYRLAFNKQELRKVIKEYP--GKEVKKGLDNLYKKVDK-----CEEENLLQVVWHSMQDEFIRQYKHFEGLIARCYPGSGVTMEFTIQDILDYC.......................................................... 887
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;