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Query: [I] KOG1175 Acyl-CoA synthetase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSNSLRHVESMSQLPSGAGKISQLNAVVLGESLASEENDLVFPSKEFSGQALVSSPQQYMEMHKRSMDDPAAFWSDIASEFYWKQKWGDQVFSENLDVRKGPISIEWFKGGITNICYNCLDKNVEAGLGDKTAIHWEGNELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQSSKDGVSVGICLTYDNSLATTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKFVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGDSRCPISDTWWQTETGGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSWPGAFRTLFGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEELGDTSTLADPSVVDQLIALADVLast
1 -189.000[I] KOG1175 Acyl-CoA synthetase  ali  100  1MSSNSLRHVESMSQLPSGAGKISQLNAVVLGESLASEENDLVFPSKEFSGQALVSSPQQYMEMHKRSMDDPAAFWSDIASEFYWKQKWGDQVFSENLDVRKGPISIEWFKGGITNICYNCLDKNVEAGLGDKTAIHWEGNELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNAVKRGPKTINLKAIVDAALDQSSKDGVSVGICLTYDNSLATTRENTKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGYMIYTATTFKYAFDYKSTDVYWCTADCGWITGHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWDIVDKYKVSIFYTAPTLVRSLMRDDDKFVTRHSRKSLRVLGSVGEPINPSAWRWFFNVVGDSRCPISDTWWQTETGGFMITPLPGAWPQKPGSATFPFFGVQPVIVDEKGNEIEGECSGYLCVKGSWPGAFRTLFGDHERYETTYFKPFAGYYFSGDGCSRDKDGYYWLTGRVDDVINVSGHRIGTAEVESALVLHPQCAEAAVVGIEHEVKGQGIYAFVTLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPGLPKTRSGKIMRRILRKIASRQLEELGDTSTLADPSVVDQLIALADV 693
2 -168.000[I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases  ali follow..  50  6................................ESILQEERLFDPPTEFSERAYVRSGREYEQLYSRAASNPEKFWGELAEQ----ELHWFKKWDQVLDWQ--PPFAKWFVGGQLNISHNCLDRHLTTWRRNKAAIIWEG-EPGDSRIITYAQLHREVCQFANALKSLGVQKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVDAEAKLVITADGGFRKDKAIALKQEVDKALEHGAPSVENVIVV-------QRTKADVTMTAGRDHWWHELQPQQSAHCPAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGYNLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYIVYGPLSNGATTVMYEGVPRPSNPGCFWDVIERYGVNIFYTAPTAIRAFIRMGEAVPNARDLSSLRLLGTVGEPINPEAWMWYHRVIGGGKCPIVDTWWQTETGGIMLTPLPGAIPTKPGSCTKPFPGIVAEIVDLDGNPVESDQGGFLVIKQPWPSMIRDVYGDTDRFRHTYWEHIQYLYFAGDGARRDKDGYFWVMGRVDDVINVSGHRLGTMEIESALVSHPLVAEAAVVGRPDELTGEAIFAFVSLEGNAEPSEELKKDLVKHVTEEIGAIARPAEIRFTDVLPKTRSGKIMRRLLRSLASGQEIS-GDTSTLEDRTVLDKLREG... 653
3 -73.100[Q] COG1021 Peptide arylation enzymes  ali follow..  21  25.....................................................................................................................VPLTDILTRHADSDKTAVIEGE------RAFSYRQLNQAADNLACSLRRQGIKPGETALVQLGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQH----TLFAGEDFLNTFVAEHRSVRVVLLR-----------------NDDGDHSLDAAMRQAAEDFTATPSPADEVAYFQLSGGTTGTPKLIPRTHNDY-YYSVRRSNEICGFNEDTRFLCAIPAAHNYASSPGALGVFLAKGTVVLATD----PSATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAPLASLRLLQVGGARLSATLAARIPAEIG---CQLQQVFGMAE-GLVNYTRLDDSPERIINTQGRPMPDDEVWVADADGNPLPPGEIGRLMTRG--PYTFRGYFNSPLHNASAF--DANGFYCSGDLISIDQDGYITVHGREKDQINRGGEKIAAEEIENLLLRHPVVIHAALVSMEDELLGEKSCAYLVVKEPLR-----AVQVRRFLREQVAEFKLPDRVECVASLPLTPVGKVDKKQLRQRLASRS........................ 534
4 -66.600[I] KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter  ali follow..  18  78......................................................................................................................ILFASTVRR-HPDKTALIFEGTD----THWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGS---------EMASAICEVHASPDPSLSLFCS----------GSWEPGAVPPSTEHLDPLLKDAPKH-SCPDKGFTDKLFYIYTSGTTGLPKAAIVVHSRY-YRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIVGIGQCLLHGMTVVIRK------SASRFWDDCIKYNCTIVQYIGELCRYLLNQ--PPREAENQHQVRMALGNA--SGSPSGPTFPAAST---YPRWLSSTGPECNCSLGNFDSQVGACYPIRLVRVNEDTMELIRGPDGVPCQPGEPGQLVGRII--RRFDGYLNQGANNKKIAFKKGDQAYLTGDVLVMDELGYLYFRDRTGDTFRWKGENVSTTEVEGTLSRLLDMADVAVYGVEVPGTEGRAGMAAVASPTGNCDLE---RFAQVLEKELPLYARPIFLRLLPELHKTGTYKFQKTELRK.............................. 602
5 -64.800[IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II  ali follow..  19  10............................................................................................................................AQYRYGAGKNCI----EDINFTPDTYRKLLTKTLFVGRILEKYSV-EGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGKLWHLPEQLTQVRWVY---------------------EDLKADVTPADKLWIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKS-ILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTPLLTGAEVFLY---PSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARF----ANPYDFYRLRYVVAGAEKLQESTKQLWQDKFG---LRILEGYGVTECAPVVSINVPM--AAKPGTVGRILPGMDARLLAVPG----IENGGRLQLK---PNIMNGYLRVEKP-ENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIAGEMVSLEMVEQLALGVSADKMHATAIKSDASKGEALVLFTT-------SELTREKLQHYAREHIPELAVPRDIRYLKQLPLLGSGKPDFVTLKSWVDAPEQH...................... 514
6 -57.500[I] KOG1176 Acyl-CoA synthetase  ali follow..  22  51.................................................................................................................................RGKTAFI----DAATDHRISFSDLWMAVDRVADCLHDVGIRRGDVVLVLSPNTISIPIVCLSVMSLGAVLTTANPLNTASEILRQIADSNPKLAFTTP---------ELAPKIASSGISIVLERVEDTLRVPRGLKVVGNLTEM------------MKKEPSGQAVRNQVHKDDTAMLLYSSGTTGRSKGVNSSHGN-LIAHVARYIAEPFEQPQQTFICTVPLFHTFGLLNFVLATLALGTTVVILP------DLGEMMAAVEKYRATTLILVPPVLVTMINKADQIMKKYDVSFLRTVRCGGAPLSKEVTQGFMKKY--PTVDVYQGYALTESNGAGASIESVEESRRYGAVGLLSCGVEARIVDNTGQVMGLNQTGELWLKG--PSIAKGYFRNEEEIITS-----EGWLKTGDLCYIDNDGFLFIVDRLKELIKYKGYQVPPAELEALLLNHPDILDAAVI................................................................................................... 478
7 -55.200[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  13  19..................................................................................................................DTPIARLLKNAKE-TPDHRFISVY-NERGIVAKYTYTELLRRVNTIAKFCDDLGL--GKTVGIHMGHELDFLCSIFALWATGRTCVIFNQIWSQQVVRVLVKRLNISDLLYHE------------YKPKFEVDTLNATSL------------------------------ASLPLDIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKK-YALGYDYGTPEFMNHLSTPMVMATSFALTTLS---WINALYCNGNLLYATCTSEAERLAWNVYYALRAGCERLIILPNLLVLTLQIMPDKEEC--FPACKLVAAGGEMVPANMYHTCKRVL--PNATIYPQYGTTESGLVSFLAYNGKDTLHNKEPGKTVKKLMLVTEDNEAVPEKIGCEGFVCVVT--DVQSEPYVGDDAETIQSRNSTFQPAVRFADLAVWNSKLGITIKGRLGRRVKRNGVFFDLKYFDQVVVGLKEVKDAFSF----FIFNRFVLVYVPAYNGVD-----PVTLKQKLNKELRDHHLFSSCFPLADIPRNAAGKVDLKSIETYASKCLSVEDQRLPVLLNPVAIEISKI... 547
8 -49.600[I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  15  16....................................................................................................................LPPPNEMLLRWAKERPNEVYLKQIINRQFVEFTYAEVADKALRLVSALRALGADPGDKVALISKNCAEWFICDLAMMLGDYISVPIFPTAGSETIDYCLEHSESKILIVGK--------LDDNKATAHVLAERPNLISISLPY--------------PSAAKCQYEFQTLIKQHQPSEERPTHFDEKLMSIVYTSGTSGQPKGAMLTYGA-FTWSAQQLINHIGIEENDRLFSYLPLAHITERVYIFGSSIIGGVLTAFPE------SLDTFIEDVKMHRPTLFISVPRLWTLFQQR-RKLADGLGLDQARVLGCGSAPVSPALLEWYRSV----GLNITEAWGMTESFAYSTLNYPF--ADKIGTVGNAGPGIELKIAED----------EEILVRS--KGLFAGYYKNDTATAESFND--DGWLHTGDIGSLDSEGYLTIQGRKKDTFKTAGKFVAPVPIEKKLFEYSRVEMMCLIG---SGLPAPILLAVPHNFPHFDRARYERTTQKVIARINSELESHEQIKGVLMIKDTPTLKIKRHVLEKKYHDVGQNWPKGQLV............... 559
9 -47.600[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali follow..  19  455....................................................................................................................LHDFVTASAET-SPQAIAVTDQDR------SLSYAELDWRADRLASGLVAAGIGRGKRVGIRLERSVELVVAILAVLRTGAAYVPLDPRYPADRIEFIAADADLALILVTT----------------------------------------ENDISTIGQNFRCMTPGMVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRN-AVAFMQWCMHAFTKDQLSGVLASTSICFDLSIFE-IFATLAAGGRIFM------VDDLFAFPSAPFAGEVTLVNTVPTPMSELLKLGPL------PQNVKTVCLAGEPLPRELVARIYANDQVEC--LYNLYGPSED-TTYSTVAPVPPSGEWFGIGVPIANTRAYVLDGEMNEVPVGVPGELFLSGS--GLARGYWNRPGQTAERFLPN-RVMYQTGDIVRRRDDGGLDYMGRADRQLKLNGFRIEPGEIEAVLLQQEGVHEAVAGLWRDAANHPRLAMWIAGDPALEIT-----KLVATLRQRLPEHFIPVLATRLDALPRLPNGKLDRSALPDAYGERATETASLLNDQEDVLAQIWQGLLGC 969
10 -47.000[I] KOG1256 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  15  80................................................................................................................GVLTTYSGIRRGPTVGGKEMLGKRVMKDGKLEWEWISYDQAFETSDHASQAIRKLGIEIGEKIGIYSNNRPEWILSEMAIHNFSNVSVPLYDTITNDDMHYITNLCEISLMFVDAE--------IKTKQLIRDKSYLSSLKYIVQF----NECSDDIKEMARENDFRLWSFNEFVEKKQKHRPHVPPTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFENEAGVQDAYLSYLPLAHIY-ERLCLLSNFMIGSRIGFSRG-----DPKLLVDDVQALAPRSFATVPRVIDKIHKAVMKQVQDKPLKNIRQLILGAAKSDVSAMRFARGAFG---VEVLEGYGQTETSGPTTLQLVG--DTRIGCVGPPMACAMIKLIDPELGYSVDKNGGEVLVK---HNVTSGYYKNPEATASSFTE--DGYMKTGDIGRFTAEGSLQIIDRRKNVFKMPGKFVAPDLTESLYTSSSFVQQIYVHG--DMEKPWLVAIVVALTKHNINGKTYEQILADDVLRQFVELTEEDKRPRYEGVYGTPTLKNKRNAIAQFFKAEIDGMYKKIETSELSNLAK....... 700
11 -41.500[I] KOG1180 Acyl-CoA synthetase  ali follow..  16  126.......................................................................................................................................IFEKWQMGDYHWRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAVQFAINEVGAKTIFTSEA--------LISKVKKAMSNGATSIENIIFFDSVDPASRGESVDVLSFDQLLSRGEREYCMLLGAYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQN-IVAVTAGQAFNIVLGPDDRYIGYLPLAHIL-EVCAEMVVFTKGVRIGYSSAQTLFDRAPKIMK-CWVLQPTLMACVPAVMDRIFKAVIDEVNANS-GKVRQILSGGAPLSPETQRFMNICFC---CPVVQGYGLTETCGGGTIADIH--DLSTGTVGPPLTCCEILLQEWAEAGYSPKNDGEILIS---PNVALGYFKNDEKTKEEFVK--KTFFATGDIGEFREDGSLKIIDRKKDLLKLAGEYISLGKVETNLLTNPNVDNVCVYG--DSNKSFLVALVVKLCEDKKVVEALQKELAQYGASKLQRVEIPQKIFICHE---TEALKLKRKNIEKAFRKELDEL..................... 724
12 -23.700[H] COG1541 Coenzyme F390 synthetase  ali follow..  16  5.........................................................................................................................................................................................................................................PAIERLNAKELEEIQERKLKALVSTVYQYSPFYRQRFREAGVTPDDIKSLNDLPKRDTYPFGMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIRNWVESLCRALCGVSSDDIMQIAYGYGLFTGGLGFHYAAERLGATVLPISAG----NTARQIELMKDLGSTVMACTPSYMIYLAEYASQ-VDIAEDTNLRAGIFGAEPWSEETRKRIEDKTG---ITAYDVYGTSELSGPLFTECTERQGLHIWA-------FLIEIIDKTGEQVGEGEKGELVVTEALPLI----------------------WRTGDITYMETD----ILGRADDMLIIRGVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGDELTVQVELSDKAEIDTKLEKKIADKLKSVLN-VWAKVEVVNPGTLQRF-EGKAKRVIDRRKI............................ 433
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Liu T, Rojas A, Ye Y, Godzik A. Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 2003 Sep;12(9):1872-81.