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Query: [I] KOG1180 Acyl-CoA synthetase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVDESDVKSALNGHDRPFTITLAIVLLKIVFFIYDVVTFIPFKIFADPAEKLEKSERVKAEPDNGDPTTPWKNVSAKDGLMNSSFEGIHDLGTQWEECVRRYGNQPCMGTREVLKVHKEKQSNGKIFEKWQMGDYHWRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAVQFAINEVGAKTIFTSEALISKVKKAMSNGATSIENIIFFDSVDPASRGESVDVDLPFTLLSFDQLLSRGEREYCMLLGAYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQNIVAVTAGQAFNIVLGPDDRYIGYLPLAHILEVCAEMVVFTKGVRIGYSSAQTLFDRAPKIMKGEHGDCWVLQPTLMACVPAVMDRIFKAVIDEVNANSELFKQLFKTCYERKRSRYEEGYTSFILNKLVFNRIGKLLGGKVRQILSGGAPLSPETQRFMNICFCCPVVQGYGLTETCGGGTIADIHDLSTGTVGPPLTCCEILLQEWAEAGYSPKNDPPQGEILISGPNVALGYFKNDEKTKEEFVKVNGKTFFATGDIGEFREDGSLKIIDRKKDLLKLAHGEYISLGKVETNLLTNPNVDNVCVYGDSNKSFLVALVVPNQKNLTQLASKAGASNDNFEKLCEDKKVVEALQKELAQYGASKLQRVEIPQKIFICHEPWTPASGLLTEALKLKRKNIEKAFRKELDELYKLast
1 -176.000[I] KOG1180 Acyl-CoA synthetase  ali  100  1MVDESDVKSALNGHDRPFTITLAIVLLKIVFFIYDVVTFIPFKIFADPAEKLEKSERVKAEPDNGDPTTPWKNVSAKDGLMNSSFEGIHDLGTQWEECVRRYGNQPCMGTREVLKVHKEKQSNGKIFEKWQMGDYHWRSYAQVDKRVNMIASGLTSLGQQEKEPIILFAETREEWMTTALACMKMNFPIATMYATLGDEAVQFAINEVGAKTIFTSEALISKVKKAMSNGATSIENIIFFDSVDPASRGESVDVDLPFTLLSFDQLLSRGEREYCMLLGAYPVPTRSKKDDLAFIMYTSGTTGNPKGVMISHQNIVAVTAGQAFNIVLGPDDRYIGYLPLAHILEVCAEMVVFTKGVRIGYSSAQTLFDRAPKIMKGEHGDCWVLQPTLMACVPAVMDRIFKAVIDEVNANSELFKQLFKTCYERKRSRYEEGYTSFILNKLVFNRIGKLLGGKVRQILSGGAPLSPETQRFMNICFCCPVVQGYGLTETCGGGTIADIHDLSTGTVGPPLTCCEILLQEWAEAGYSPKNDPPQGEILISGPNVALGYFKNDEKTKEEFVKVNGKTFFATGDIGEFREDGSLKIIDRKKDLLKLAHGEYISLGKVETNLLTNPNVDNVCVYGDSNKSFLVALVVPNQKNLTQLASKAGASNDNFEKLCEDKKVVEALQKELAQYGASKLQRVEIPQKIFICHEPWTPASGLLTEALKLKRKNIEKAFRKELDELYK 726
2 -146.000[I] KOG1256 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  27  2.............SYRGLNLITRQVISRLTFRYSGLFTRITYPISVQDRGFFFGKRRVPRNQSIIQEDGGRKAAWLGDGLQHGWFEGVLTTYSGIRRGPT-VGGKEMLGKRVMKDGK---------------LEWEWISYDQAFETSDHASQAIRKLGIEIGEKIGIYSNNRPEWILSEMAIHNFSNVSVPLYDTITNDDMHYITNLCEISLMFVDAEIKTKQLIRDKSYLSSLKYIVQFNECS--DDIKEMARENDFRLWSFNEFVEMGKKQKHR------PHVPPTPETLATISFTSGTTGRPKGVMLTHLNMCSATMSCEEFENAGVQDAYLSYLPLAHIYERLCLLSNFMIGSRIGFSRGD---------PKLLVDDVQALAPRSFATVPRVIDKIHKAVMKQVQDKP-LKKMILNAAIAYKLYHYKMTTRKTWVDKYVLHKIQMLLGPNIRQLILGAAKSDVSAMRFARGAFGVEVLEGYGQTETSGPTTLQLVGDTRIGCVGPPMACAMIKLIDVPELGYSVDK--NGGEVLVKGHNVTSGYYKNPEATASSF---TEDGYMKTGDIGRFTAEGSLQIIDRRKNVFKMPQGKFVAPDLTESLYTSSSFVQQIYVHGDMEKPWLVAIVVPDPEYLASYALTKHNNGKTYEQLCNIPILADDVLRQFVELTEEKRPRYEGVYGVHLTPVAFSAENGLTTPTLKNKRNAIAQFFKAEIDGMYK 688
3 -109.000[I] COG1022 Long-chain acyl-CoA synthetases (AMP-forming)  ali follow..  23  5............................................................................QPNQFNHPPCALPPPNEMLLRWAKERPNEVYLKQII-------------------NRQFVEFTYAEVADKALRLVSALRALGADPGDKVALISKNCAEWFICDLAMMLGDYISVPIFPTAGSETIDYCLEHSESKILIVGKLDDNKATAHVLAERPNLISISLPYPSAAK------------CQYEFQTLIKQHQ--------PSEERPTHFDEKLMSIVYTSGTSGQPKGAMLTYGAFTWSAQQLINHIGIEENDRLFSYLPLAHITERVYIFGSIIGGVLTAFPES----------LDTFIEDVKMHRPTLFISVPRLWTLFQQRIQDKLPQKK-----------------LNILLKIPFVNSLIKRKLADGLGDQARVLGCGSAPVSPALLEWYR-SVGLNITEAWGMTESFAYSTLNYPFRDKIGTVGNAGPGIELKIAE-------------DEEILVRSKGLFAGYYKNDTATAESF---NDDGWLHTGDIGSLDSEGYLTIQGRKKDTFKTAKGKFVAPVPIEKKLFEYSRVEMMCLIGSG-LPAPILLAVPHNF-----------------PHFDRARYERTTQKVIARINS-ELESHEQIKGVLMIKDPWSIDNGILTPTLKIKRHVLEKKYHDVGQNWPK 555
4 -64.100[IQ] COG0318 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II  ali follow..  19  1........................................................................................ETLYESLLAAQYRYGAGKNC----------------------EDINFTPDTYRKLLTKTLFVGRILEKYSV-EGEKIGLMLPNAAISAAVIFGAVSRRRIPAMMNYTAGVKGLTSAITAAEIKTIFTSRQFLDKGLWHLPEQLTQVRWVYLEDLKADVTPADKL-------------------WIFAHLLAPRLAQVKQQPEDAAIILFTSGSEGHPKGVVHSHKSILANVEQIKTIADFTANDRFMSALPLFHSFGLTVGLFTLLTGAEV-------FLYPSPLHYRIVPELVYDRNCTVLFGTSTFLGNYARFANPY---------------------------------------------YRLRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKPGTVGRILPGMDARLLAVPGIE-------NGGRLQLKGPNIMNGYLRVEKPGVENSRGETERGWYDTGDIVRFDENGFVQIQGRAKRFAKIA-GEMVSLEMVEQLALGVSADKMHATAI-----------KSDAEALVLFTTDSELTREKLQHYAR----------------EHGIPELAVPRDIRYLKQ--------LLGSGKPDFVTLKSWVDAPEQH... 514
5 -61.600[Q] COG1021 Peptide arylation enzymes  ali follow..  17  49.........................................................................................................................................FSYRQLNQAADNLACSLRRQGIKPGETALVQLGNVPELYITFFALLKLGVAPVLALFSHQRTELNAYAMQIAPTLVIADRQAGEDFLNTFVAEHRSVRVVLLRNDDGD---------------HSLDAAMRQAAEDFTA--------TPSPADEVAYFQLSGGTTGTPKLIPRTHNDYYYSVRRSNEICGFNEDTRFLCAIPAAHNYAMSSPGAL--------FLAKGTVVLATDPSATLCFPLIEKHQINATALVPPAVSLWLQAIQEWGGNAP----------------------------------------ASLRLLQVGGARLSATLAARIPAEIGCQLQQVFGMAEGLVNYTLDDSPERIINTQGRPMPDDEVWVADADGNPLPPGEI---GRLMTRGPYTFRGYFNSPLHNASAF---DANGFYCSGDLISIDQDGYITVHGREKDQI-NRGGEKIAAEEIENLLLRHPVVIHAALVSELLGEKSCAYLVV----------KEPLRAVQVRRFLRE----------------QGVAEFKLPDRVECVAS--------LTPVGKVDKKQLRQRLASR...... 533
6 -60.200[I] KOG1176 Acyl-CoA synthetase  ali follow..  21  41...............................................................................................................ITTFISSQTYRGKTAFIDAATD--HRISFSDLWMAVDRVADCLLHVGIRRGDVVLVLSPNTISIPIVCLSVMSLGAVLTTANPLNTASEILRQIADSNPKLAFTTPELA-PKIASSGISIVLERVEDTLRVPRGLK-----------VVGNLTEMMKKEPSGQAVRNQV-------HKDDTAMLLYSSGTTGRSKGVNSSHGNLIAHVARYIAEPFEQPQQTFICTVPLFHTFGLLNFVL-------ATLALGTTVVILPRFDLGEMMAAVEKYRATTLILVPPVLVTMINKADQIMKKYD----------------------------------------SFLRTVRCGGAPLSKEVTQGFMKKYTVDVYQGYALTESNGAGASIESVERRYGAVGLLSCGVEARIVDPNTGQVMGLNQT--GELWLKGPSIAKGYFRNEEEI------ITSEGWLKTGDLCYIDNDGFLFIVDRLKELIKYK-GYQVPPAELEALLLNHPDILDAAVI......................................................................................................... 478
7 -56.900[I] KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter  ali follow..  17  75.........................................................................................TVPILFASTVRRHPDKTAL-----------------------EGTDTHWTFRQLDEYSSSVANFLQARGLASGDVAAIFMENRNEFVGLWLGMAKLGVEAALINTNLRRDALLHCLTTSRARALVFGSE-MASAICEVHASPDPSLSLFCSGSWEPGAVPP--------STEHLDPLLKDAPKHLPSCPDK-------GFTDKLFYIYTSGTTGLPKAAIVVHSRYYRMAALVYYGFRMRPNDIVYDCLPLYHSAGNIV-------GIGQCLLHGMTVVIRKKFSASRFWDDCIKYNCTIVQYIGELCRYLLNQPPREAENQH-----------------------------------------QVRMALGNASG--SPSGPTFPAASTYPWLSSTGPECNCSLGNFDSQVGVYPIRLVRVNEDTMELIRG-PDGVCIPCQPGEPGQLVGRIIRRFDGYLNQGANNKKIAKDVKGDQAYLTGDVLVMDELGYLYFRDRTGDTFR-WKGENVSTTEVEGTLSRLLDMADVAVYGPGTEGRAGMAAVASPTG-------------------------NCDLERFAQVLEKELPLYARPIFLRLLPE--------KTGTYKFQKTELRKEYVPLDQEAYS 632
8 -43.200[Q] KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes  ali follow..  12  19........................................................................................DTPIARLLKNAKETPDHRFISVYN------------------ERGIVAKYTYTELLRRVNTIAKFCDDLGL--GKTVGIHMGHELDFLCSIFALWATGRTCVIFNQIWSQQVVRVLVKRLNISDLLYHEYKPKFEV----------------------------------------DTLNATSLASLPLDIDAPCIRAGLEPEVALINHSSGSTGVPKSMPFLMKKYALGYDYGTPEFMNHLSTPMVM--ATSFALTTLSWINALYCNGNLLYPSSSISATCTSERLAWNVYYALRAGCERLIILPNLLVLTLQIMPDKEECFP-----------------------------------------ACKLVAAGGEMVPANYHTCKRVLPNATIYPQYGTTESGLVSFLAYNGKDTLHNPGKTVKKLMLVTED----EAVPEKIGCEGFVCVVTDVQSEPYVGDDAETIQSRNSYDGQPAVRFADLAVWNGKLGITIKGRLGRRVKR-NGVFFDLKYFDQVVVGLKEVKDAFSFFIFNR-FVLVYVPAYNGV----------------------------PVTLKQKLNKELRDHHLFSSCFPLAD--------RNAAGKVDLKSIETYASKCLSV... 528
9 -41.500[I] KOG1175 Acyl-CoA synthetase  ali follow..  16  136.............................................................................................................................HWEGNELGVDASLTYSELLQRVCQLANYLKDNGVKKGDAVVIYLPMLMELPIAMLACARIGAVHSVVFAGFSADSLAQRIVDCKPNVILTCNANLKAIVDAALDQSSKDGVSVGICLTYDNSLATTREN------TKWQNGRDVWWQDVISQYPTSCEVEWVDAEDPLFLLYTSGSTGKPKGVLHTTGGMIYTATTFKYAFDYKSTDVYWCTADCGWITHSYVTYGPMLNGATVVVFEGAPNYPDPGRCWD-----VDKYKVSIFYTAPTLVRSLMRDDDKFVTRHS----------------------------------------KSLRVLGSVGEPINPSAWRWFFNVVGCPISDTWWQTETGGFMITPLPGPQKPGSATFPFFGVQPVIVDEKGNEIEGECS---GYLCVK-PGAFRTLFGDHERYETTYFK---AGYYFSGDGCSRDKDGYYWLTGRVDDVINVS-GHRIGTAEVESALVLHPQCAEAAVVGHEVKGQGIYAFV---------------------TLLEGVPYSEELRKSLVLMVRNQIGAFAAPDRIHWAPG---------TRSGKIMRRILRKIASRQLEEL.. 672
10 -41.100[Q] COG1020 Non-ribosomal peptide synthetase modules and related proteins  ali follow..  19  442.............................................................................NETDAEFQPQRRCLHDFVTASAETSPQAIAVTDQD-----------------------RSLSYAELDWRADRLASGLVAAGIGRGKRVGIRLERSVELVVAILAVLRTGAAYVPLDPRYPADRIEFIAADADLALILVTTENDISTIG--------------------------------------QNFRCMTPGMVENLAGGAVPTPVTSGADLAYLIYTSGSTGRPKGVAIEHRNAVAFMQWCMHAFTKDQLSGVLASTSICFDLSIFEIFATLAAGGRIFMVDDLF----------AFPSAPFAGEVTLVNTVPTPMSELLK---------------------------------------------LGPLPQNVKTVCLAGEPLPREVARIYANDQVECLYNLYGPSEDTTYSTVAPPPSGEWFGIGVPIANTRAYVLD---GEMNEVPVGVPGELFLSGSGLARGYWNRPGQTAERFLP-QHRVMYQTGDIVRRRDDGGLDYMGRADRQLKL-NGFRIEPGEIEAVLLQQEGVHEAVAGDAANHPRLAMWIAGDPAL----------------------------ITKLVATLRQRLPEHFIPVLATRLDA--------RLPNGKLDRSALLNDQEDVLAQIWQ 964
11 -40.700[I] COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases  ali follow..  18  93....................................................................................................................TTWRRNKAAIIWEGEPGDSRIITYAQLHREVCQFANALKSLGVQKGDRVAIYLPMIPEAAITMLACSRIGAPHSVVFGGFSAEALRDRLVDAEAKLVITADALKQEVDKALEHGAPSVENVIVVQRTKADVTMTAGRD------HWWHELQPQQSAH---------PAEPIDSEDMLFILYTSGSTGKPKGVVHTTGGNLYTHMTTKWIFDLKDTDVYWCTADVGWITGHSYIVY-LSNGATTVMYEGVPRPSNPGCFWD-----IERYGVNIFYTAPTAIRAFIRMGEAVPNARD----------------------------------------SSLRLLGTVGEPINPEAWMWYHRVIGCPIVDTWWQTETGGIMLTPLPGPTKPGSCTKPFPGIVAEIVDLDGNPVESDQG---GFLVIK-PSMIRDVYGDTDRFRHTYWE-EGQYLYFAGDGARRDKDGYFWVMGRVDDVINVS-GHRLGTMEIESALVSHPLVAEAAVVGDELTGEAIFAFV---------------------SLEGNAEPSEELKKDLVKHVTEEIGAIARPAEIRFTDV---------TRSGKIMRRLLRSLASGQ...... 632
12 -14.800[H] COG1541 Coenzyme F390 synthetase  ali follow..  15  11...............................................................................................................................................................................................................NAKELEEIQERKLKALVSTVYQYSPFYRQRFREAGVTPDD------------IKSLNDLPKLPFTKKQDLRDTYPFMFCVPLSQVVRFHASSGTTGKPTVVGYTANDIVESLCRALVSCGVSSDDIMQIAYGYGLFTGGLGFHYAAER--------GATVLPISAGNTARQIELMKDLGSTVMACTPSYMIYLAEYASQM--------------------------------------GVDIAEDTNLRAGIFGAEPWSEETRKRIEDKTGITAYDVYGTSELSGPLFTECTER------GLHIWADMFLIEIIDPKTGEQVGEGEKGELVV------------TTLTKEALPLI-----WRTGDITYMETDGR-RILGRADDMLIIR-GVNVFPSQIEHVLMQIPEVGEHYMIIVDRREDGLDELTVQVELSDKAEIDTTGDILKLEK-----KIADKLKSVLNVWAKVEVVNPGTLQR....................................... 419

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Nika K, Tautz L, Saito K, Cerignoli F, Friedberg I, Godzik A, Mustelin T. Identification and characterization of DUSP27, a novel dual-specific protein phosphatase. FEBS Lett. 2007 May 29;581(13):2527-33. Epub 2007 Apr 30.