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Query: [TW] KOG1226 Integrin beta subunit (N-terminal portion of extracellular region), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDREPYMTENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGTLast
1 -194.000[TW] KOG1226 Integrin beta subunit (N-terminal portion of extracellular region)  ali  100  1MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDREPYMTENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGT 788
2 -17.400[T] KOG3512 Netrin, axonal chemotropic factor  ali follow..  12  2VRATGTRMGLLLPIILALAIGSSAAGISSNDPCYFEGKPRKCVQASSVCGAQQPERY------CELLRDGNAGECRSCEQQRYGPA-------ALTDLNNPSNVTCWRSGAVNVPHDPDSAPPDNVTLTLSLGKKYELTYISLSFCPRSPRPDSLAIFK----------------SSDFG----QTWQPF-------------QFYSSQCQKFYGRPDRAKISKFNEQ-AQRFAFNTLEGRPSANDLDSSLVLQDWVTATDI-------RVVFHRLELPPQLLKVKNANAFSDEMGGSREEDEDDDADLELDGEQDEYDYNLQDNDSADAGYDEYEEPKKHLELDDDHLHLDYASDGESVVKRQGKHKGSAYEKHYQSKLAATTPPQQPPKVTPPGKVTPPSTAAPSAAASAVTLPISQHYAVSDFAVGGRCKCNGHASECVA----TVSSGSGTALSDQDDGQDEDTPSAPSLANHFGR-LTMTCACKHNTAGPECECKPTDNDANECKMCQCNGHARRCRFNLELSGGVCYCQHDTTGRYCHY-CREGYYRDATKPPNHRKVCKRCDCGQCPCKEGVTGLTCNRCARGYQQTRSHVAPCGGGTGDYKDGGGS-QVEEMKKYCGKCKASPKKLNLNKFCMEDYAILAKVIGHDRASQSIERQNEIYKYEINIQTIFKRNPMSGTTSSLLGRGNVPRKSIECQCPKIKLNKSYLILGRDSEA-----GYLAIGPSSVVLEWK-------SLRMKRFQRRARKCS........................ 793
3 -10.500[O] KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family  ali follow..  11  191...........................................KGGEHCYY-GVKDSKVALSTCNGLHGMFEDD-TFVYMIEPLELVHDEKQYSKQMKNLTMERGDQWPFLSELQWLKRRKRAVNPSRGIFEEMKY-LELMIVND-HKTYKKHRSSHAHTNNFAKSVVNLVDSIYKEQLNTRV---VLVAVETWTEKDQIDITTNPVQMLHEFSKYRQRIKQHAD---------AVHLISRVTFHYKRSSLSYFGGVCSRTRGVGVNEYGLPMAVAQVLSQSLAQN---GI--QWEPSGCIMEETGVSHSRKFSKCSILEYRDFLQRGGGACLFNRPTKLFE-----------------------------------------PTECGNGYVEAGEECDCGFHVECYGLC-CKKCSLSNGAHCSDGPCCNNTSCLFQPRGYECRDAVNECDITEYCTGDSGQCPPNLHKQDGYACNNQGRCYNGECKT----RDNQCQYIWGTKAAGSDKFCTEGTEKGNCGKDGQCFCGFLLCTNLTRAPRIGQLQGEIIPTSFYHDGTPCGPSMMCLDRKCL--------QIQALNMSSCPLDSKGKVCSGHGVCS-ATCIC-DFTWAGTDCS................................................................................................................................................................... 769
4 -9.830[W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases  ali follow..  200...................................................................................RREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADH---LYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEKGLHFVIQRTSI---TPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGL-AWVASPICQVHQRYNEGSRGWVYRSLNTGIHEIGHN---GSPHDFPAECQPGLP----------------------DGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPV-------DPTRNASPVGIGKRNCFQERTSAFCGNQ-----------YEPGEECDCGFSQADCDQMGDKC---------------------CVPHEARGNGGPGPCKRKPGAQCSQGYCTCSLHGKNEEKECSNLQTCDGRNAQCPVSHDGIPCDSTKVCSSGQCVCAMGKADELCFLACIKDGKCTSSVHLPEFSANLILHPGSCNNYKGYCDIFRKCSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGG................................................................................................................................................................... 753
5 -9.290[P] COG4548 Nitric oxide reductase activation protein  ali follow..  14  358.................................................DHCRVISGPAKDA--ETAPEPDPDTKNLIRRVRRQFEVLRPRHELLRAQLDGNDLDLDAVVRARSDIAAGGQGSDRIHVA-SRPQAHDLAVTILVDVSLSTDAWFDNRRVLDVELAHGLSACGDIHSITFTSRRRSWV------------------------------RVETVKDFDEPMGHTIERRALKPGFYTRIGP--AIRHAS---AKLHERPERRKLLLLLT--------DGK------PNDVDHY---EGRFAIE------DSRRAVSEARRSGVSVFVTVDSKAQSYIPAMFGQNGYAIVSRIAKLPSALPAIYRS................................................................................................................................................................................................................................................................................................................................................................................................................................ 629
6 -8.800[R] KOG1235 Predicted unusual protein kinase  ali follow..  11  146.....................................RAVKALSTRPDIL----QELSKLQDQIPPFPTTVAMRCIEEQLGAPVSKLADISLKPVAAASLGQVYKAHLHSGQLVAVKVRPGMSLILT----------RDALLFKMIGGQLKDLLVAVNEMVRHMFDEIAKNAERFASLYSF--DSGNEQIDDNAGPRNMSRNHRAENIKVPKIY------NFTRTAVLTMEWIDGIKLTDEIKLKRASLDR--------RDLIDQGLSCSLKQLLEVGFFH--ADPHPGNLVATKEGSLVY-----------FDFGMMGNIPRHYRVGLIQILVHFVNRD---SLSLANDFLSLGFLPEGVDIQAVSNALRTSFGSTTRI........................................................................................................................................................................................................................................................................................................................................................................................................................ 462
7 -8.610[K] COG5175 Transcriptional repressor  ali follow..  10  16.....................ALSNFDTSFLSEDEEDYCPLCIEP---CQFCYNNQNPELNGRC---------ACRRKYDDENV-RYVTLSPEELKMERAKLARKEKERKHREKERKENEYTNRKHLSGTRVIQK---NLVYVVGINPPVPYE---------EVAPTLKS--EKY---FGQYINKIVVNRKTPHSNNTTSEHYHHHSPGYGVYITFGS----KDDAARCIAQVDGTYMDGRLIKAAYG-SSYLRGLPCPNEPGEEADS-----FNKRE.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 266
8 -8.500[U] KOG1985 Vesicle coat complex COPII, subunit SEC24/subunit SFB2  ali follow..  11  219.SLLKKSKIPFALVIRPYTSLVEEDDPVPVVTDTIISRCRRC--INPFSIFIDN----GHRYRCNS--------CGI------VNEVPQSYDWDSFRNVQRDRWQRPELNYAVVDFIAPQ--------EYMVRAPQPLVYVFLIDISFVSISS-GMVGTASRAILESLDRIPGRAKVAFIGV-DSALHFFSVSPGAEEATQLVVSDLEEPFLPRNQDLLLNLRECRQGIENLLERQSMFATTRDSSNALGPGLKAAHLIENIG------KICCLISSLP--NVGVGKLE---LREDPKLLGTNRESSLLHPNDSF--YKSFAVECSTSQVSVMFLFSSQYQDVLSCLPRYTSGKTQ................................................................................................................................................................................................................................................................................................................................................................................................................................................ 542
9 -8.490[R] COG5219 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  13 1407........................................QCLRHLSSSVYWSE----KNRAFTSTVESFTGYNVSPLLI---SASLDDVERSIESEDFQSVGDVNVKVNRNTREISFI--DEHKLEMAIKIPSVYPLQNVQVEGIERVGVNERQ-LSSQNGSITDALLVLKKNISMHFEGVEE-SVLSVERTLPNKRCGTCRHKFHASCL----YK-----------FKS-------SNSSRCP-----------LCRSSFTF............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 1609
10 -8.460[L] COG0188 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit  ali follow..  13  36................................................................DIRDGLKP----QRRVLYAMKQLSLSPGAKHRKCAKICGDTSGDYHPH--------GESVIYPTLVRMAQNWAM--YPLVDPPAAMRYTEARLTHSAMYLMEDLDKDTVDIVPNYETKHEPVVFP--SKFPNLLCNGSSAVGMATNIPPHNLGELIELLANPQASVDEILQV-MPG--DFPTGGIEGIRSASIIITEMPYNVNKSRLI----EQIANLVNEKTLAGISDVRDES---DKDGIVVLEIKKGESSEIIINRLYKFTDVQVTFGAN................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 333

FFAS is supported by the NIH grant R01-GM087218-01
1 4 0 5 8 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24