current user: public

If you have questions about the server, please let us know.

Query: [IG] KOG1340 Prosaposin, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
    .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320    .  330    .  340    .  350    .  360    .  370    .  380    .  390    .  400    .  410    .  420    .  430    .  440    .  450    .  460    .  470    .  480    .  490    .  500    .  510    .  520    .  530    .  540    .  550    .  560    .  570    .  580    .  590    .  600    .  610    .  620    .  630    .  640    .  650    .  660    .  670    .  680    .  690    .  700    .  710    .  720    .  730    .  740    .  750    .  760    .  770    .  780    .  790    .  800    .  810    .  820    .  830    .  840    .  850    .  860    .  870    .  880    .  890    .  900    .  910    .  920    .  930    .  940    .  950
# Score Template Links and tools%idFirst MERAGLLAVLALCCAFGVFAAATPLLGSSKCTWGPSYWCGNFSNSKECRATRHCIQTVWETQKVPVDTDSICTICKDMVTQARDQLKSNQTEEELKEVFEGSCKLIPIKPIQKECIKVADDFLPELVEALASQMNPDQVCSVAGLCNSARIDELYKNGIQAGLDGTVQNEDDSSEETELAMQPNQLSCGNCNLLSRLMHSKFAATDRDDMVETMLHMCGSLSSFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKGFKDECLSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSASSMKDVPIMPLLPVIEPAQVKITIEKLEKHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFDPGFTAAPNCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDVPPKQVCQKLQLCFSVAVTDEVLECGVCHGVTQALLPFLREKKDNVSEVTALQMTSVGCENLPAKYYKICSEMISIYGSSIKNLAKRPYIDQSHICAEIGKCFESEKSSLAFARISALast
1 -173.000[IG] KOG1340 Prosaposin  ali  100  1MERAGLLAVLALCCAFGVFAAATPLLGSSKCTWGPSYWCGNFSNSKECRATRHCIQTVWETQKVPVDTDSICTICKDMVTQARDQLKSNQTEEELKEVFEGSCKLIPIKPIQKECIKVADDFLPELVEALASQMNPDQVCSVAGLCNSARIDELYKNGIQAGLDGTVQNEDDSSEETELAMQPNQLSCGNCNLLSRLMHSKFAATDRDDMVETMLHMCGSLSSFSDACANIVLTYFNDIYDHVSKHLTTDAVCHVSGVCASRYHQHEEEKQPQEALVALDAGDDIPCELCEQLVKHLRDVLVANTTETEFKQVMEGFCKQSKGFKDECLSIVDQYYHVIYETLVSKLDANGACCMIGICQKNSASSMKDVPIMPLLPVIEPAQVKITIEKLEKHEKKQLGASEPKFSQQEILDMQLPIDHLMGAANPGALVEGGELCTLCEYMLHFIQETLATPSTDDEIKHTVENICAKLPSGVAGQCRNFVEMYGDAVIALLVQGLNPRDVCPLMQMCPKNLPKKEDVEVFNPQPASDEQDPPTCPLCLFAVEQAQMKIRDNKSKDNIKKVLNGLCSHLPNEIKEECVDFVNTYSNELIDMLITDFKPQEICVQLKLCPKTTYALWDLRISLEDDVDGEDKSSSEEISFNDIESLEELPPQLAFDPGFTAAPNCLICEELVKTLEKRMGKHPTRDSIKHILEESCDRMRKPMNTKCHKVIDKYGDKIADLLLKEMDPKLICTELGMCILADLDDLEVDEALKYDVIALPRQDNKLSSSIKEPPTCVLCEFIMTKLDADLKNKTEQDDIKRAIEAVCNRLPATVRKQCDTFVDGYASAVLKLLSDVPPKQVCQKLQLCFSVAVTDEVLECGVCHGVTQALLPFLREKKDNVSEVTALQMTSVGCENLPAKYYKICSEMISIYGSSIKNLAKRPYIDQSHICAEIGKCFESEKSSLAFARISA 953
2 -17.100[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  2.......................................................................................TSDIAMQLIAILEKTVS--PDKNELLSAKNFLEQFLKALSEILVNTANSAVARMAAGLQLKNHLTSKDEKVSQQYQDRSEIRELIKNNILAALGTENTRPSCAAQCVAYVAVIELPINRWPMLIQTLVNKVVSEGSHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAATTALHNSLEFTKSNFEK-NFIMEVVCEATQCQDSQIC-VAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDECDDEDTWSPAKAASVCLMVLATCCEDEIVPHVLPFIKENIESPNWRFR-DAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDS-------------------------------SVIVRDTIAWTFGRICDIIPEAAINETYLQTLLECFVKSLKSEPRVAANVCWAFLSPYFEYIITQLLETTDRQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQINNHSDRHQFNDLQSLLCARKVHEQDAPQISDAIMTALLTMFNSSAGKSVVQEEAFLAVSTLVELLGAQFAKYMPAFKDFLVMGLKNFQEYQVCCAAVGLTGD--------------------------IFRALKDLMVPYSNEIMTVLINNLTEPTIHRTVKPQVLSAFGDIALSIGNHFLPYLSMVLDMLRVASNLQTDANYTGIIQGLKGVDQTAHTDVMHMEPHLMHIISFIKRIAQEGDVSDSMLASAAGFIGDLCTSFGPRLYPLLDAIITQFLAEGKRSKAQRMLCTWAVKEIKKINTQVIT...... 883
3 -16.900[U] COG5215 Karyopherin (importin) beta  ali follow..  1MSTAEFAQLLENSILS-IRLTSETQLKKLSNDNFLQFAGLSSQVLIDENTKLEGRILAALTLKNELVSKDSVKTQQFAQRWITQV--SPEAKNQIKTNALTALVS----------EPRIANAAAQLIAAIADIELPHGAWPEL---------------------------------------------------MKIMVDNTGAEQPENVKRASLLALGYMCEADPQSQALVSSSNNILIAIVQGAQSTE---------------------------TSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVAAAFGCLCKIMSLYYTFMKPYMEQALYALTKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGN----HILEPVLEFVEQNITADNWRNR-----EAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQS---------------------------LQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQDHPKVATNCSWTIIN-LVEQLAEATPSPIYN-------------------------------------------------------------------FYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDE------------NQLTLEDAQSLQELQSNILTVLAAVIRKSPSSVEPVADMLMGLFFRLLEKKD-SAFIEDDVFYAISALAASLGKGFEKYLETFSPYLLKALNQVDSPVSITAVGFIAD----SNSLEEDFRRYSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTL....................... 741
4 -16.400[I] KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein  ali follow..  13....................................................................................................................................................................................................................................................................................SSSSSNPRGKCWLILVLMAVL---------------PLVADVGALPFLFTHIKPQINWTQPEMESWVIEEQPRSIEPHLEPVLHPNRTHRALSSDSTDAEFLQRLVSIRHNQTASSRMLWYDVAGGDGLVYPPFVDKALKLLNLKQVAFEIENSVMSKVTCTACRAGAGMLQHQIQSGKTDAELIRMITDYCTNLNIQSARVCQGVAQLFGSELIYVLKRNLSPDELCSFV---AAPFFKVLHISDTHYDPHYAEGSNADCNECDTPKRTVDHMLSHIAETHKDIDYILWTGDLPPHDVWNQTKEENLAIIKDTVKQMVEMFPGVPIFPALG--NHESAPVNSFPPPYVNQVDISISWLYDELDIQWRRWLPQSVTHTVRRGAFYSVLVRPGFRIILQWFIYELQSAEFSNEVIGHIPPGHSDCLKVWSRNFYKIISRYESTVTAQFYGHTHYDEFEMFYDPHDLNHPNGIAYIGPSVSPYYDLNPGYRIYYVDGDHDATTRLVIDHESWIMNLKEANLYGYNMKALRPSDWNNLLNELTNNQELFELYYKYYWKNSPARPTCDAECKKRLICDCRSGRS--HDRKHF--CAEVESKI-----DEESSKSWKSWFYKGLTNSAEDRTEEPAPTTDGYGPFDVVIV................................ 731
5 -15.600[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  7..................QHELEQVIQLLQHAHSTDR--VQLVQLNEHQKFCCYLVYILSDMKEMIDATSRSLAGLLLKNNIRAKWNPQDVKFFVRTTCLKSIGD-QEPLIRATVGIIVTTIVPDLLDTLATVLMQPD---------------------------LMQEGALGALQKVFEDSADRYESEFLRPIMPKLLVFYEHHAAKMRALAMNCVNCILMVNNDPIDFAIDQFLTSLFARHNDNDEEKQLCRSLTLLLDTHIEKMMPHLP---------------NVIEYIIKKTQD--HNESIALEACEFWLSIAENSDICRTMVLPHLDKLIPVLLGSMRYSETDPALKANDEDSSVPDREEDIKPRFHKSKQHGLGGLVESDDEEDEDDDDDGGGDWNIRRCSAASLDVLASIFGK----------------DLLDKLFPLLKDTLMNDN---LVKESGILALGAIAEGCMDGVVPHLGELIPFMLAMMFDK---SITCWTLSRYSSHIASDENFRQ---------------QFFKDVLANLLRCSLDGNKKVQ-----EAACSAF-ATLEEEAGEQLIPFLGEILDQLVKAFQCYQ---------------------------------------AKNLLILYDAIGTLANSVGDALSHPVYVQMLMPPLMEKWERLSDEDKELFPLLECISAIVSAMGQSFLPYIQPVFTRCCSLIEKCVQQNDLLSGLAESLPEHMDPLVANSKLVELMLFCSLDVTPDVRQSCFALLGDLTKACPERVLPQSSNDPSKISVCNNAIWALGELALKMGPAMKQFIGPIIEPLIVVINSQQNMQRTLLENTAITIGRLGQCCGEELAPHISRFVRPCCYSLRNIKDNAEKESAFIGLCNMINMN-----PVGVLNDFIFWCDAIASWTVPTDSLRVLFAGILQSFKQQVGDFNWNN 864
6 -15.000[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  374..............AELRERKILRLLLKVKNGTPPMRKSALRQLTDQARDFGA-------------------ALFNQILPLLMERTLEDQERHLLVKVIDRILYKL---------DDLVRPFTHKILVVIEPLLIDED--------------------------------------------------YARAEGREIISNLAKASGLAHMIATMRPDIDH--------DEYVRNTTARAFSVVASALGVPALLPFLAVCRSKKSWQARHTGVRIIQQIALLLGCSILPHLKNLVDCIGHGLEDEQVRIMTALSLSALAEAATP------YGIEAFDSVLKPLWSGVQRHRGKSLAAFLKATGFIIPLMEPEYASHFTRRIMKILLREFNSPDEEMKKIVLKVVSQCASTDGVTPEYLRTDVLPEFFHCFWSRRMASDRRSYKQVVETTVVLAQQVGSRQIVERVVNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRCKPYLPQIVSTILYRLNNKSAREQAADLVSSITIVLKACGEE---ALMRKLGVVLYEYLGEEYPEGSILGAIKAIVSVVGMSSMQ----------------------------------------------PPIRDLLPRLTPILRNRHEKVQ-----ENTIDLVGKIADRGSEYVSAREWMRICFELIDMLKAHKAVNTFGYISKAIGPQDVLATLLNNLKVQERQNRVCTTVAIAIVAETCMPFTVVPALMADYRTP--EMNVQNGVLKSLAFMFEYIGEQARDYVYAITPLLADALMDRDAVH-----------------------QTAASVIKHLSLGCVGLGVEDAMIHLLNILWPNILEESPHVINAVREGIDGPIMAYLVQGLFHPNTYWTSYNSAYVQSADAM....... 1164
7 -13.200[K] KOG2461 Transcription factor BLIMP-1/PRDI-BF1, contains C2H2-type Zn-finger and SET domains  ali follow..  7.............................DDGVPPAPFSSAAAAAHSPPHSPLSVGVSSASSATSSSSTPPSSTSPAGVSASGARNVETDWKQSGDENLAELCIFVPDKSVSLPNPKRAECTLPMNLILKSSSKNRKKS-RGVRFGPLVGEIRLVDVDTALVCPAEASMAGGGPAQEDVPFDEAPEEWKIYSPSGGRLNKTICVKDDARS-----MKYVAAAEEEDFQNLVAAQIGNDIYFYTVKKIEANT--LSFWFSRDYARKLNYSTRPYVRVRRPATQLIPSAPPASASTAIASLAETIVAIDYSVKKLIESPID-------TLSTDASSASDEEMIDVEEQESCTRPVAEVT---------------------------RPNVIQNPVVRPVATKVNNFPGIPVRLGNFYASPLVDFKEFMRKSLQLKLVDTSMFVSPVAQTTAAITATGGRSQPIDVQPVLAA--------TAGAHFGNYAAIYGQDFQHELSKPLYTSASPAFMGGGFGMGGSAHTSSFHQLPFVNHSSSSHNDSSFNGVPNYVQQQENGKTRYA-----CK--------DCNKTFGQLSNLKVHVRTHTGERPFKCEI---CTKEFTQL-------------------------------AHLQKHHLVHTGERPHRCDICDKRFSSTSNLKTHLRLHNGQKPY---TCD--------VCDAKFTQYVHLRLHKRLHANERPYSCGT---CGKKYISPSGLRTHWKTTTCKEEDMKSMRDDLMDIKGEIDEGSMSGSGYGNLGIFENTLN--------------SELKRPLMPIETIYSKYNLPNASLLGQGP------------------SGMQEQQAPPPTSQQQQHMMYGNTMGHMGQG---LQGPPPPPQHFQMDHSGMQNGGGIPHQHQLIQGGPSS-GSG---QQQHPQHNGIHRL... 800
8 -13.100[YU] KOG2022 Nuclear transport receptor LGL2 (importin beta superfamily)  ali follow..  1MDGNEI-AHAKKLVYDLYSAATEKELQKAQRSQQGWNIGLFM-LQSKDVYEQFFGALTLQMKINTQLETLSDKDLVQLFVQLLQKLLWDDGLPAL--VERKVICTLASLTIKYELEKKEEASLKVIYCLFCNKLEFFNADMNAASVLNNLFPPASSRNAQLTASYINELLLELSFSIYTKENEDALFNNVFRPCSNIIVSVLVFIFTNYSLDLSKEKNVAALEEALNCDEVSEKAMNCLADLLANNFITQPTIERLWTILTGPWGETHLQQELEDPDSGEENDYSFLNIVIGFAEAMLPQIIDHIQEEKSIRLLYILASLLAIVEEKVSWRTLEFWTTLIEDFSMSKAATD--SKDEIFKQIAFSVVEKAWWKMLLPSPEQWNSWPSSSRDSFNSYRRDLGDLLESSYSIFGERLYAMYITTIENFFSDGTGSPQSLEVSFYCLCCILEYDDSDTLDAWLTRLFETSFAIKASALLKTCSQLLSSCSCFL------QNHPQYLNISLPVLFDALHISETSIQMTVSRS-----HTLCTTCASLLTEIDGFMAVPSVLEKIYSSVGYVTQRIEDI--ELRISYLMRLLNCILAQLQPSLYPNL----------------EIFENVLKSCLQSVAGVALSQSPIGESPIIDVEQSTQETTFWQQSCIAEFQAKLISFLTHSESMALQYSDV---VGLICKIMIAGLNEVEPSPFSLPIVTTIQYFCDRFTEFPAAVLLTLGSA-----------------------ILTCPYGQTDIIDKVLIDMCSSIQNSVNNIDITVELYHFFSIILQKHPSFLETMYPDFTQLILNRAINLLGKPERLLESAAGQFIISKSDLLNTHTDFVNAIRSPLIAKILLGFGGNASRPLLSDILGKLKAQNFSATRACLTQSLRRFLTDLLKARIKDKVKQ-ILCKGL.................. 978
9 -13.100[U] KOG2081 Nuclear transport regulator  ali follow..  2.......................................................................................DTYSVDVVYQAISALFQ--NNPKEQEKANKWLQD--------FQKSIYSWTIADEL---------------LHQKRDLHANYFAAQTMRNKIQNSFSELPPHTHESLRDSLITHIGQIDEQTDNVIVTQLSLAVADLALL----MASWREPINDLLVTLAPHQCAIWPLLEVLKVLPEEIDSRYLRLGANRREEVHKQLDASAECVLKFLCMCLQREDLDQQWNAALRTYSAWLVIHAFPVSHVYNNLTQLAFRLLSLPETSGKLHDNATECVCALLSCINTRQDGASDPESSFEAQLFGAVCMLETPYHLSVAHEDTDKTINYCRIFTSLCDAFFYDLLADAQKPHYSLKGLDLVLLCVG--HFDYEVAEITFHLWYKLSEDLFQRNEDKLTVLFRPHIERLISALFRHSQ-RKVSDLIKDVAFIVGSGACFKQMFHILQAPETTWESTEAALFIMQNVAKNILPDENEPKVVEAILNMSEQTHIAVRYTAILLIGELLEAVLNFLLYALQQTSICSA---CRQKMVCHI---------------------------------------------------SGLVEIARSLDSFQINNDVAIGLLKGISLILTRLPREQLQPALREIVGFQLQPLAQLVDSTG--------STPQKGERTDPVYWIDRACAIIRHTNPDVPDNVEHPTVAILNDAWQLISRVMDKYQSDLRIMERTCRLIRYGIRMVRKQAMMLVEPLIKQMVVLYSVQHHSCFLYVGSILVDEFAKSSECIGGLLEMLQAFIEPTFGLLDHREANSSVMKFFINLLVWGNTECRPLVVELASQHGGALVMNLIQA............................. 830
10 -12.900[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  39................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SYTGNDDNACVVC-----------------KNVEIFSIGDCD-------------------------------HPVCYE---C-------------------------STRMRVLCQQNECPICRHVLSKVRIGFCTAEIRQQFFKLLDHPC--------PKCDAPPYRTFEGLRNHVRSEHKLLYCD---LCVETLNNRSHRGHPLCEYCN------KRYVDRDELFRHLRR--HYFCHF--------CDA--NEFYND-YADLAEHFRAEHFLCEE---CATEQ........... 271
11 -11.700[R] KOG3782 Predicted membrane protein, contains type II SA sequence  ali follow..  14  4.........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VSTLVCLISLSGIQSASVSSLECGACSLLVTHFELKIAAARSESHLTEIIEHACDDARYNLQNACNDFIDSHEDELLGFLKTAHQDVKQFCGEMGACTAVDVAP........ 169
12 -10.900[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  452........................................................................................................................................................................................................................................................................................................................................................................................................................................................EDALLALSKKLMEMPVKEDLKNTLRASVFLVRRAIKDIVTSVFQASLKLLKMIITQYIPKHKL----------------------------SKLETAHCVERTIPVLLTRTGD--SSARLRVTAANFIQEMALFKEVKSLQIIPSY---LVQPLKANSSVHLAMSQMGLLARLLKDLGTGSSGFT-------------------------------------------IDNVMKFSVSALEHRV--YEVRETAVRIILDMYRQHQASILEYLNTRRNILYKTIFEGFAKID--EIQAEVQEKESDAVKPKNQDIQGGKAAPAEALGIPDEHYLDNLCIFC--------GERSESFTEEGLDLHYWKHCLMLTR---DHCKQVVE-----ISSLTEHL--------LTECDKKDGFGK------CYRCSEAVEELPRHIKHKDCNPAKPEKLANRCPL--------CHENFSPGEEAWKAHLMGP-------------CTMNLRKTHILQKAPA 884
13 -10.800[YU] KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily)  ali follow..  2...............ELSDANLQTLTEYLKKTLDPDP--KFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKR-RVAIKANSSPEQIQKQLSDAISIIGREDFPQKWPDLL----TEMVNRFQSG-DFHVINGVLRTAHS-------------LFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISDLPEFWEGNMETWMNNFHTLLTLDNKLLQ--------EAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVQNTLTSICEKVIVPNMEFRAADENSEEIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEF--PVLKADGIKYIMIFRN---QVPKEHLLVSIPLLINHLQAGSIVVHTYAAHALERLFTMRGP---NNATLFTAAEIAPFVEILLTNLFKALTLPGSSENIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMF----------------------------------------EAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEPYVFQVMSLLLETHKNDIPSSYMALFTGNIPALVRLLQAFLGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPLEKIIIPEIQKEKKICAVGITNLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTILAQSLHMLSTACPGRVPSMVSTSLNAEALQYLQGYLQA............................. 965
14 -10.800[U] KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3  ali follow..  326...............................................................................KNVSHLIQERHFELAIQEQKLEIKKKAALNLFNQK------KFDESFALFGEIKTDISEV---LSIIRMFPELLPDGFQSMTGVVSDMPANDRMRALLALGSYLSE--------IRTEHAKHIELYNRLYSSGAAKKTDEDEKAKLLLTLRVVDTTLLKCYIKTKPMLVDSLIRLQSNACTFEDAKKILESEGRLRSLFILYETRKK----EMALDLFIDQSSRPDADPFFDDAIQQIVEYLQSLGNSNLPLILKYAKWVLAK-----NLEAGVQIFTSDETEMARNLNR-----------------------------------------------------------------------KAVVEFLKSE-----CPDALIPYLEHVIFKWEEPSSYFHETLLEFYVARVNTLFKDYVHAFPDDENITRAGDEDGEL-----------------------GLYRKRLLKFLEVSHSYS-----PQTVLLQLAPHAFYEERALIEQALAIYVNTLKNVPAAEEYCRLYYNAHDETNSQVYLMLFRTLVHPNQQQLHSIPYHADSTPFGSYRDDVSEASTLVNSTS-----QPDVNTAIKILAKHADKIDTVGALN----MLPATTP----RVVFSAINAVIQTTGRQASTRKMEKSV-------------SQCAMSKKLERKNKAQSTKIIVNFSSECVVCEKKIAVSAFVRYPDGR------LAHLYC................................................................................................................................................. 913
15 -10.800[S] KOG4367 Predicted Zn-finger protein  ali follow..  11  2............................................................................................................................................................................................................................................................................................................................................................................................................................................EEMEEELKCPVCGSFY-----------REPIILPCSHNLCQ--------ACRNILVQTPESESPQSHRAAGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSP----------NGVRVFPPAMPPPATHLSPALAPVPRQCHRSLNRVLEGVIDRYQQSKAAALKCQ---LCEKAPKEATV---------------------------------------------MCEQCDVFY-----------------------CD--------PCRLRCHPPRGRLVPPAQGRVSRRLSPRKVSTCTDHELENH--------------------------SMYCVQCKMPV-----------------------CY--------QCLEEGKHSSHEVKALGAMWKLHK--SQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQE--NSVEFEACLVAQCDALIDALNRQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQI 385
16 -10.700[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  11.................................................................................................................................................................................................................................PGPSYQNIKSIMEDSTILSDWTNYDFSCELYRMSTYSTFPAGVPVSERSLARATGVNDKVKCFCCGLMLDNWKL--GDSPIQKHKQ------------LYPSCSFIQNLVSASLGSTSKNTSPMNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEP--KDDAMSEHRRHF-------------PNCPFLENSLETLRFSISNLSMQTHA--RTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRC-----ESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTT-YKTVNDIVSALLNAEDEKREEE--KEKQAEEM-------------ASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFI----------CGHLVVCQE------APSLRKCPICRGIIKGTVRTFLS......................................................................... 618
17 -10.700[T] KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins  ali follow..  12  383....................................................................................................................................................................................................................................................................................................................................................................................................................................................VAPSFRPEDELEHLTKKMLYENPPADEYFGRC--------ARCGENVVG-EGTGCTAMDQVFHVD--C-------------------------------TCIICNNKLRGQPFYAVEKKA----------YCEPCYINTLEQCNVCSKPIMERILRATGKAYHPH--CFTCVMCHRS-------------------------------------LDGIPFTVDAGGLIHCIED-------------------FHKKFAPRCSV--------CKEPIGQEETVRIVALDRDFHVH--C------------------------------------------RCEDCGGLLSEGDNQ---------------------------------------------PLDGHILCKT---CNSAR-------RVLTAKASTDL.................................................................................. 612
18 -10.600[S] KOG4623 Uncharacterized conserved protein  ali follow..  29..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................VYISIRSRYDARVNC----FC----------------------NGNVRVPYQDRNSWTCPSCEQY-----NGFTKD-----------DYNRDITSQRDCSLGS----------QKNSSKGSSSICANSYYSDVLTAQPPAPKNGLCDQCNEKVEKLSQFEPKNESRKVYRERLEKLC--------SSCERHVNKVLHEKKKMVLSSKFL.......................... 191
19 -10.400[D] COG5657 CAS/CSE protein involved in chromosome segregation  ali follow..  2......................DDIPTLLARTLNPTTSKSAEEALKVWELQDSSFALKLLNIVAEDTVDINIKLAASLY--FKNYIKKDEVAELIKREIINLMLK-STTIIQVQLGEVIGYIADTLLPDLISKLSAVDMNTNIAVL----------STAHAIFKRWRPLFRSDALFLEIKYVLDRFCEPFLALFVQTNNLLRNGPQDAESLNSLFQVILLECDIPEFFEDHMSEFMTAFLNYFTYTNPSLE--------GETNVLIKVKASICEIVELYTLRYEEVFTMLYDFVNVTWTLLTTLTPDEKYDGLVGKAMAFLTSVDQVLQQFIELVVLPNICLRESDEDPLEVRRDLEGSNSDSRARSAIVLVRGLLDHFDQKITSVVSTHINANLQQFSTNPSLEWNKKYVALQLFSAIAIKGQSTRLGVTSINLMVDVVAFFENNIKPDLLQPA--GVIHPMVLAEDIKYVFTFRNQLN---SQQLIDIFPTILRFLEMPSFVVYTYAAIALDQLLTVRHNHVHIFTSLLIAPHILPALNQLFLIVESA-QKLAENDYLMKAVMRIIIMSQEAILPAASLLLQHLTKITEEVSKNPSNPESIGALIRSLSKSGPQTVSQLENALLPVFQNVLIEDVTEFIPYVLQLLSQLVEASGNEPLPDPALVRLLRAMIFRGPQIFISNKFVEPVLGIFQKLFDLLDRVFTVFNANILAPYINHIFFLLLSRLKNSRTERFVLRCTIFFFFVASEQTGTCGPDNLIQGVDAVQSGVFGQ-----MTSIILPQAQKLALPLDRKISALGLLRLLTCDLVLAPDAIYENLIIPLLTCILKLFEMPIEQAQTDA----DEIDADSMSFQASFSRLATTGGKRVDPFPQITDLKQYCATEMNLANRNMGGRLSQIISTHLPGDGQSVLQSYGYV............................. 966
20 -10.300[YU] COG5101 Importin beta-related nuclear transport receptor  ali follow..  2..............EGILDFSNDLDIALLDQVVS--------------QGSGVQQKQAQEILTKFQDNPDAWQKADQILQFLDKLITPNDHRIGIRNFVVGMIISMCQDDEVFKTQKNLINKSDLTLVQILKQEWPQNIPELIGSSSSSVNVCENNMIVLKLLSEEVFDFSAEQMTQAKALHLKNSMSKEFEQIFKLCFQVLEQGSSSSLIVATLESLLRYLHWIPYRYIYETNILELLSTKFMTSPD-AITLKCLTEVSNLKIPQDNDLIKRQTVLFFQNTLQQIATSVMPVTADLKATYANANGNDQ--SFLQDLAMFL-------TTYLARNRALLESDESLRELLLNAHQYLIQLSKIEERELFKTT-----------HNLVADLFYEVQRLPATEMSPLIQLSVGSQAISTGSGALNPEYMKRFPLKKHIYEEICSQLRLVIIENMVENDEGEIVREFVKES-IQLYKSEREVLVYLTHLNVIDTEEIMISKLARQIDGSEWS--------------------------HNINTLSWAIGSISGTMSEDTEKRFVVTVIKDLLDLTVKKRGKDNKAVVASDIMYVVGQYPRFLKAHW----------------------------------------------------------------NFLRTVILKLFEFMTHEGVQDMACDTFIKIVQKCKYHFVIQQPRESEPFIQTIIRDIQKDLQPQQFYKACGIIISEERSVAERNRLLSDLMQLPNMAWDTIVEQSTANPTLLLDSETVKIIANII----------KTNVAVCTSMGADFYPQLGHIYYNMLQLYRAVSSMISAQTKTPKVRGLRTIKKEILKLVETYISKARNLDDVVKVLVEPDARDAEVLNCMTTVVEKVGHMIPQGVILILQSVFECTLDMINKDFTEYPEHRVEF.................. 859
21 -10.300[BD] COG5098 Chromosome condensation complex Condensin, subunit D2  ali follow..  64....HLTPKLQTQLSYLISSSLSNLSKDIKANLSSNVIQVLLTFLQDELHKVSSQSTNLNRSAKNSKNDSA----ENLLESITKLLETTPEKDLFIGLFTRPLFVLLEIEPVTKVSSLKMFIQRILAMCVKNHGQSSSIQSSL---------------------TNLTYFLHLSVFNAELLKLLNDEYNYPQLTEDILKEISTRVFNAKDTTGPKAISNFLIKLSELSPGIMLRQMNLVITLLNNSSITLRCSVVEACGNIVAELAQDPQTMEHYKQQI-----------AVLIELLEERFQDSNPRTKAIQGCSKICDFTSLAVRSLQDRSSLVRRNSVKLLSKLLLKHPFKAIHGS---EEYLKGSESQLNSTLKKVESQETLNDTIERSLIEEEVEQDEGQCRTELEGSFNKSAELSRIENEVENINATNTSVLMKLKLMIVYYKDAIS----IKEIHKSIELISNLLFSKNRNEVLESMDFL---------------VLADAFDIELSEFGIKKMLHLVWMKGTNDEGTSISVHLIECYKQLFLTAPDSCNMQEKAAHIAKNLINLSIGSLEQLLGMMYEQIDQHVINILFSKEQIHGSIIILGMLSLADNEIALKGLESLLNIGLGAVGLKDLTLCRYSCLALERMVPKRSTIITKA-------DVAVKKLYAIIINYTKDNEYYPMCEQALSAL-SKPDILATDLIREKTMMTFGKPEESSRVVSLSQLLFIVGQVAIKTLVEKCEAEFKKRKIEAETRNGKVKNQGADVTNTTQDNGGDKELEMIGGTNEDDFTDAIQFVKE---NELLFGEKSILGKFCPIVEEIVSNSSRFSDPMLQRTATLCLEKLMCLSSKYCEKSLPLLITVMEKSPDPTIRSNAVLGLGDMAVCFN--------NLVDENTDYLYRLILAGQVKVKGQLGEMAKCLDNPDQGIS...... 1068
22 -10.200[YU] KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily)  ali follow..  1MQVDPVVYQLQRDAEGHLNNFFGKLYSIFLDKQNDMSL-RWIAIIQLRNSIDIIWRKNTKMSLLPEER-------DFIRCNALLGSIKS--ENLLSIQNALVVSRIARLDYPTEWPSLFHD----LLGKLQQSLGTGDYDVALRLLIYKLAPELLTILQPILHSSLSSWMMILESSKEIKDSTLLSYMQISRYTLKACRRLVESEFSERMLAFCAVHQRKLLSMVGECLEMAFAHAFLFNKPFFDFSFYSPCLTKFPATIDYISLHYDFLGQISSHLSSYKEKFEE-KLVIMSLRVFILVIQEFCNTKSSHPETAQVLYNSFLVDNRINNLLDLLITKLLILKEEDFSPQQWVL-----------EQSTQDVEFNVRPCAEKLLKCFFDAYGDIIVSPFKDMIYSVFECPKTLTQAVQQDTLISSFGVGYTQLKSIFPFAKWLQEAAVPNMASINDIGISRVYRRRIAIFLSQWIEDSSSEQLLEVIYKLYCSFLNLTDPCNAVVILTTIDAFKTVLDDWNF---------SENSFLSIKENLFVHVLSLFKAFESVDAILSLLGTLLARAGEHVAPMESTIASLLSQLWDGWKKEPLLRARVLAVMHQFVNAIKAKSFEFSTFLYTVIEYCVNPESPEHVIFEADAMELWSTFLMYIQKLPETFTLLIPHLLYHLSQA----------TSTLPFVLMIVSSYQLLDNTVLMKDYSFTIFEKLNDLLDDVKLCKTVCLL-----------------------ETTPMDMIYESLLNSSLLSRLLLSIATNDKHPQVLIEYLLVVSRISLREPELILKVCQTKNINIAMLIGNWILLNDHDRKLNTLALSSLLRTNHPDVLAVLDSIMNLWFSVLSEVEEDANGDATSRSFFISVFMFCRDANGGM-NQYLSTVNPALLEQFQS.............................. 981
23 -10.000[O] COG5656 Importin, protein involved in nuclear import  ali follow..  1................MVQE--QAILSCIEQTMVADA----------------------KIIKEAEQQLFEFQKQPGFTSFLLNIVSDDNFALNVKNKIHRSWDTKREDGIKADEKLSIKE---RLIETLVKNCENNHIRPILTETINGILVGQEDWD-----------------------------------IIKNLLSSGDASYIYPGLLLLFQLCKAH-GSRDYIDSVIEELFPIVEGIASNIGSDYRSNEILYLILKSFKYACLNNLPQYFSQPERIMS---VQLHLYLCSKPLPVEVMELDPADRVKVNKWGFGNLNRFLQRYNKITKAITKEFIDYIFNTIVPIILREFFKDIEAWGNNSLWLSD------------------------------------------------------------------SSLYFLISFLEKCVTIDQLYPLIEPHLQIIFENVIFPCLCANEQSIELLEDDQEEYTRRYFDINREGSTPDAASADFIFLIGSKR---------------EKLNNILPFINDIFTRFDAEEGALRTLSNLFSFIDE--PSVLENIFGHFIVPLLSQDKYMFLVARSLETIALYSEEFKDMNILSQLFELTYTNFLNSNVLPVQIEAADAIKCLIVSNPQIHPAVSAHVPGMMEKLLK-----LSKIFEIDILSEVMEALVERFSDELSPFAKDLASNLVEQFLRIAQALVENPS---------------ETYSASDQEQEIQASGLLQTMTTMVMSMNKVPLIESLAPVVKFVVLHAQISTEAVDLLDALTISSHLLYNQIAPPIWELL-HDILDSFQTYAMDYFEAYSIFFETIVMTGFPQ-----TYVQPLLEILSAKLESEVDYDIEMRDIPLFSKAIKVSTNDELGLDSKCIVKLGLANL---FAKPIETLQIME................. 793
24 -9.720[TDBLU] COG5032 Phosphatidylinositol kinase and protein kinases of the PI-3 kinase family  ali follow..  680SALQQIASTRHISVWQLLSPYWPTVSVAIVQGM--SLFAQLMNI-SEGDFLIRTQAYTLPFLVLTKNKALIVRIAELSQSDVATLCLTNNLEESVMLLLSLATSDFEKVDLTSLLRSDPISITVELLQLYQNDVPHEKIENALRKVAMIVSQVVNDEDLSNKELLYDFFNNHI--------------------ILAEFSNILNDLKGKTSINEKIKTIVGIEKMLSLCGGAVKLGLPQILSNLQSAFQNEHL-----------------------------------FYAIKAWFSLILATKEPEYSSIAGLSLVILPPLFPYLEPQEAELVIQIFDFISSDTHKCL--QGLKWAIPTSLDSACFSLKAKEIFCSLQNEDFYSELQSIIKCLTNENE----------------------------------------PVCYLGLQKLELFFQAK--VDELHDTLNL----------DISNEVLDQLLRCLLDCCVKYASTNM-N--LGELGAIDPSRAKAQHIIKETVVLDNFENGEESLKFILDFMQSQLTDTKAQGFLAYALQEFLKLGAVINKKKGLTVVTEHWMSLPDLSKRVLIP--LTSKYHLTPIPKIDIRYPIYKENVTIHTWMQLFSLKLMEYAHSQNAEKIFGICSKVVKDQEV--NIPCFLLPFL-NVILTESELEEFQLVINQPGPDGLNSVGQQRYTSFVDVFFKIVDYLNKWLRMRKKRNWDRRSAIARKENRYMSVEDATSRESSISKVESFLSRGIVSLNCGFHARALFYWEQHIRNATAPESDYRVLQEIYAGIDDPVSLNFHDYSFDQQLLLHENSGTWDSALSCYEIIIQKDPENKKAKIGLLNS---ESLVLSLDSFIINDHEYSKMLNLGIEASWRSLS---DSLKKCLSKLGSIFYQYLRKD--SFAELTERLQPLYVDAATAIANTGAHS 1589
25 -9.390[R] KOG4331 Polytopic membrane protein Prominin  ali follow..  54...............................................................................................................................................................................................TTIDQFITFVSYPFPHQELLNDQALT-ELQSSVEKKYWQWIEFQKGWIVLSVGLVA----CCVCICSRSSK--------------KQNTDARYDGCKFTLLMTSQAQIGLDK--LPNRMNQCVDDLQSYKRDSDMRIRKLLIDDYQVLNSTITKQLS------TAGYNVVDRVKKLTGAHVIDVFMNISKVAQEMHDGLESVHGKVRFLNEEGSRFEAEFSRLRNTANEELVKCLENELEPVRSMCAKAERLLESLAVTQFKIDQKFLPDATETGLSEIVNANITQVLAASNNQFEQL----------ESRIQHEI---------------------------------DKETYSAQNMLKQ--IGDDLFLVAETISTQLRKVTFEALYSTVSYVSDPKKTPTLK-----ALIFLFGVCGRRPTYYNDDCCVRSTGGKFYSFGIGAFLLIFVFLAVGTSALMFA-----VGNFSNLVCQP--------MRNPLSHPESLSLADRY-SKSPAEIIRACSR--NETLYNFYG-FDKKYHLNKLQDFEKDAYNQLQISLRTTMENMPEIRPLDAFISRSELRDLEKLASVNVSKVSQQGLNAIKHAMDELDLASKTREFEESLDAGRPKAVTLVLEQIRELEIQFAKPLRSEALYSNITSLDEKL--------------SQLQVPVSSLLVKQHAQALLAENMREHFGRAAKEEFQQMVNNIDQYIVHVKSQMESEVTS----CQPLTVCAY-------IDPYNG 790
26 -9.370[O] COG5207 Isopeptidase T  ali follow..  10  1...................................................................................................................................................................................................................................................................................................MAVEMTGKFIQKESPKSFSHSEMAEAVLENVNSKDECIYCFESPYNEPLALNASPKHSLNICCFQATCNRHVPLHIRVTEYACDTIHSNYLTIAKVEKPKQENV------------EENNNNKKIKLQVIETSEDDTHNTIWSLQRFNGENVPRTVLSKSTDSDISSTALEKIEKILKAKSQDFEDKKNSWVLEI---------------STCPHTENFQIPSKPEN------------TVNLNQCSSC--------------DLTQNLWLCLH--CGNI-------CSHALDHYRSNAIKLGSLSSSTYDLCYA---CDDETRFPDNVNL----------GSALQIYGINIQEKIADEKTLVQLQVEQNENWQFRMVDSSGKEFEKLSASKNYGCGLIN-LGNSC-----------------YLNSVIQSLVNGGVPNWSLDFLG------------------------SKFPLDVVYPDNNLKCQWIKLLMKCEPELYPNGIKPTTFKKCIGQNHQEFSSNRQQDAMEFLTFLLDLLDKKFFSSSSSGIPNPNDLVR------MMEDRLQCNICGKVKYSYEPTLEENDEPQDMLERIKAYCANCKEKVTANKKPGFKSLPQTLILNPIRIRLQPVKTSNELSL................ 568
27 -9.330[S] KOG2939 Uncharacterized conserved protein  ali follow..  1......................................................................................................................MDRFKEQLAKTVNQIGEQFSSDSDVKVLLDNMNEKVMSSYDAPSCSESPPIAPESNSQNSTPRRVKSKISEEDDVINSIDAAYFIDNDEFDAIDYELKKLCDIEMCYEDIQRERFRLKSQH-TVVSKKIS-TLIMQKSSSYTAQVGEMEKIRDEVGSVINEILTIRKALALATSQTRTCLGLIAYKNKKIVLNQLKMTL--------TTIKGFHET------QHIRETIEEGNFPLAIQMLIETQIKAGGYAHFTCV------NEVISKLAGMSCLLEAELSAQLSTIAVVFDSEKYRFVYTAYEMLEKTEQVAEKLLTAFVEAIETTTSAVVLSKEEDRLEDSSYTSLCLKLDSEQASIT---FREMGFVLCRSFQAFHKILNFHSSESASEASQSIYKQLLASRT------------EVFLAATRRLQVLVESRDFVEHILDIVDTIHQKLAESIEKRTETYFDRYHTERMEELSMFFENES--CQAAIRSRLQSSYSQKSERSYSTSSAATEIQNENYNPNLTKQESFSEDPLDEPSGVPPPNLCNTALNLLRFFGRYLR-----------MTALLPTLCSKSAPAIIDLYEFFFASMCHMFGSEGAEFVISRKFTKDEKANSPFRKVFQKDGDFLSGKMYPSLSPAVQIAFIDNLYGACERIIAVNSIEFVARQLDLIRPVIESL---LLEDTREHLSTILDAFYTQVLPCQADARLKSLIDSVTSVKWDIGELRSEHNAYVDLLVQDYELFSIRITAIKETAPVERAIYYSFKALVQGYGGKCST-FQMILMKVYPNCGKKIQKKTSEKGNIHLC............... 891
28 -9.250[U] COG5173 Exocyst complex subunit SEC6  ali follow..  3...........................................................................SDPLQQVCDLIKGDLSLERVRDIKEQLLKE--KSVVEYQLNKESDKYYGEVEESLKLLNLSKNSVTSI----------------------------------KQQINEVNKLGNDNRFAINRYDILFRATKLYETVNTTSSIYDRIYNFVALMEH--------IERLLVAELAEDAL----------------------------ETGCPHLLEIHFLLTSARDFQEQKEATEDAQRTVMKLFSRLSGIISKFDKLLDGLTYDIVEMARAE-QISLAIRLFKIYDLEEREDLRIEAIRNIIKKKEIEIEKSSIKKLPNSKNTARLQDETPKVIEYPTNKGLYQEIMSGTISTRTAPRG----FLINGINNSISEMFGEMREKNELIIVKEHIANCCPPHWN--FEVYFDQYHSLITDLVESEPETIIILDILAFDKTFQDTL-----------------------KQDFGFTKSEVKSVIGDKEKETLFKDYLNLIVVKMTEWIGNLEKAEFDVCFQMFTQQVEAKILVGVVERFSDQKNWISKISEEIKKQINYNHKYDIDPESITPEDECPGGLVEYLIAVSNDQMKAADYAVAISSKYGKLV-SKVYEKQITNHLEGTLDGFAEVAQCSSLGLITLMFDDLRKPYQEIFSKT-------------------------------------YMGSQAQQIADTLDEYLLDIKPQMNSVLFVNFIDNVIGET--------------IIKFLTALSFEHSFKNKNNKFLEAMK-----------------RDFEIFYQLFVKVLDGNESKDTLITQNFTVMEFFIDSILDIWQKYLEVYWDSRIDLLVRKDVSSSERKKIVQQATEMLHEYRRNMEANG 787
29 -9.200[S] KOG0212 Uncharacterized conserved protein  ali follow..  1.............................................................................MDNLLVRGLTHKDKRKATAYELERVVKGYLENDETEKIRAVIS----QLANDFVYSPARGPNATFGGLIGLAAVAIALGPKIDSYMESILLPVLYCFNDSDSKI----------RYYACESMYNIGKVAKGEVFRYFNLIFDVLCKLFADTEITVKNGAELLDRLIKDIVMQQAATYMSSAEDIKNFKEGPVSSSIQDVPVMSTEQPRMHTFLSELVPLLSERLYVINPNTR-----MFLVSWIRLLDSIPDLEFISYLPFLLDGLMNYLSDP----------NESIRIVTSNCLYDFLREIQKIAKVKYHILQRDEESEPDFFDSMVRRNMSDAELKEISDYVESSLRDGSFILEAHIQIDYKRILEIIIDHLGSS--VPLIQEKALKWLFEFIYIAPKDVLLQIPKVLENLLPLMSNDENMRQSAKDLSQNLVILVSKIMDIEFSGSETNNKDNSLSVDF-RSLIEVLQKLLSNDNEETRLCAL--EWVLLLQRRTGGKLINMHDPIFQTLLLQLSD--PSDLV------------------------------------------------------------------VSRTLELLAHIAISHKSVNLVPFLKSLLQMFAED-----RKFLNSRGNLIIRQLCNYIEGERVYTSF-------------------------------AGILETEENLELASIMVEVLNNNLFTAPELYDLRKKL---------------KQSAPKLQNIFTTLYTAWCHNSI-AVFSLC---------------------------LSQNYEHAANLLSVFAEI--EFNIDMLIQLDKLVQLIESPVFTYMRLQLLEPKALYGILMLLPQSSAFRTLRDRLQC 704
30 -9.160[U] KOG2066 Vacuolar assembly/sorting protein VPS41  ali follow..  10  341........................................................................................................................................................................................................................................................................................................................................................................................................................................................KKVGRMIIEGYLTGKRARAAASRLPLICGECKEEWEWAVNQFEEEVLPDGTPTLDPECYQKVLIACLF--NNVKQFRKLVQTWSPDLYMTSFIIDRTQWRIQQISKSGNLADVDETERVLMDALAHLYLYE-RKYESALKILMSCQDFQIFNVIDKHQLFDLVKDQIELMNINSERALRLLLDNADSVEPSFVMEKIGRQPKLQLAYLTKLMSRNEGTEFADKAVQLYAEYDQKKLLPFLRKNAN--NVNKAR-KLCSD--KGYIEETIYLLAKSGYDAVKMMVREY--RNMEKVIDYCKDQNDPDLWIHLLGVVAEFPAHFSQLIIEASNCLDP-----LLIMDKLPDDSDIPNLSEALDKLLVD--YTNHAELQQCCYDSTLNDLNVLTQGLISAADESV--------------SVNIVSRCSLCAQII-----INSNQETTKKFSDIKVFKCGHI---FHLAC----------STSEMERRQSIEEGLCI---ACSDQIELI........ 805
31 -9.150[S] KOG3682 Predicted membrane protein (associated with esophageal cancer in humans)  ali follow..  30.......................................................EEGSQKELLNLTQQDYVNRIEELNQSLKDAWASDQKVKALKIVIQ--CSKLLSDTSVIQITDILDTFGKLVYERIFSMCVDSRSVLPDHFSPENANDTAKETCLN----------------FKIASIRELIPRFYVEASILKCNKFLSKTGISECLPRLTCMIRGIG------DPLVSVYARAYLCRVGMEVAPHLKETLNKNFFDFLLKQIHGDTVQNQLVVQGVELPSYLPLYPPAMDWIFQCISYHAPEALLTEMME-----------RCKKLGNN--ALLLNSVMSAFRAEFIATRIGMIKECDESGFPKHLLFRSLGLNLALADPPESDRLQILNEAWKVITKLKNPQDYINCAEVWVEYTCKHFTKREV----------NTVLADVIKHMTPDRAFEDSYPQLQLIIKKVIAHFHDFSVLFSVEKFLPFLDMFQK------------------------------------ESVRVEVCKCIMDAFIKHQQEPTKDPVILNALLHVCKTMHDSVNALTLE-LSYLINGFIKMVSFGRDFEQQLSFYVESRSM----------------CNLEPVLVQLIHSVNRLAMETRKVMKGNHSRKTAAFVRACVAYCFITIPSLAGIFTRLNL--YLHSGQVALANQCLSQADAFFKAAISLVPEVPKMINIDGKMRPSESFLLEPDHPEHGVLFLVRELLNVIQDYTWEDNSDEKIRIYTCVLHLLSAMSQETYLYHIDKVDSNDSLYGGDSKFLAENNKLCETVMAQILEHLKTLAKDEALKRQSSGLSFFNSILAHGDLRNNKLNQLSVNLWHLAQRHGCAD--TRTMVKTLEYIKKQSKQPDMTHLTELALR......................................... 817
32 -9.150[U] KOG2034 Vacuolar sorting protein PEP3/VPS18  ali follow..  10  380..................................................................................................................................................................................................................................................................................................LKVYAAALANCRDPLQRDQVYLVQAESAFTDKEYLRAASFYAKINYVEVTLKFISINEPEALRTFLLHKLDNLSKDDKCQITMISTWATELYLDKINRLLLEDDTAIENRDSEYHSVIQEFRAFMSDCKDELDEATTVKILESYGRVEELVYFANLKEQVVLHYIQQGEAKKALEVLQK------SSVSVELQYQFAPELIMLD-----AYETVESWMANKNLNPRRLITAMMRYSSGPHAKNET-----HEVIKYLEFCVHRLHNEDPGIH--SLLLSLYAKQEDDGALLRFLQCKFGKGRENGPEFF--DPKYALRLCLKERRTRACVHIYSMMSMH---EEAVALALQIDPELAMAEADKVEDDEDLRKKLWLMVAKHVVKQAIAFLKETDGLLKIEDIL----PFFPDFAL------IDDFKEAICSSLEDYNKQ-----------EQLKEEMNDATRGADNIRNDISALTQRYAVIDRDEECGVCKRKISGDFRMAQGYSSAGPLAPFYVFPCGHS---FHAQC---LITHVTSCAHEEQAEHILDLQKQLTLLGSETRRDINGNRSD--------EPITSTTTADKLRSELDDAIASEC----------CGELM-------INEITLPFIKPED--TSWDLRSETNLANQRTISLP. 993

FFAS is supported by the NIH grant R01-GM087218-01
1 4 0 1 8 2   jobs submitted since Jan 1, 2011
Comments and questions to: webmaster

Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Wooley JC, Godzik A. Probing metagenomics by rapid cluster analysis of very large datasets. PLoS ONE. 2008;3(10):e3375. Epub 2008 Oct 10.