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Query: [P] KOG1418 Tandem pore domain K+ channel, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDVPTFILHSADTESVISDDDSSYYFDGSVEQLTLRNQEYSDDNRMQRRAPIRRKSALDDDQTSQAMKLLEKYIRKKYRHSVIFSQDSADIEQSSTPVGHTQSACQFSRNLTPEQRNGFYSTPLGPAPSEYHFPPGSPQFRESTIREEFKQQYRETWGHWFVRVGKFLYKLLGIQYMLLALMILGYACLGGYIFLTLEYDQQQLDLEVEKQVRLSESTLLAENLLKYLKQWNCGQSNENRCLELITKAFIERSIKVERDIRGEGWRYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGEHSIKWAQKVRYSIRRCVKRCFRRSKLKRASTIESVASDEMPCEESGISEDEEQITTFPVKWALFIVFFFMVVCSLIVSFWEKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACGNGLLEIKICYISVMINGALKMSGDAVNFPRFLNTKIQLTEKFQLYLISALFVLYFVGLALFSMVYAILQERVENQYMWALELIDQEYQENQKQDPDDHLEIPTILPENAAGMEGWTNTIGKMVSQNPVRWRAKNSAYSMENMPDRPISERRFSVLSPGEAPQAPPPVLGTFMLHSLSVKKKLLARSESILNRTGSPWPHAAEMNRPKEATRLGEPSALRVSAPNLTISGGNRSPSGGALSVITEASDEDTRHFKKHRRPLAKTVSTDGTVSNHGSAESLDQVMDELQLESHDQAVTPKPYRDPTTSTRFRKRDETVVSRAEKMPLSPNEVLEEEDEDENGDTLast
1 -132.000[P] KOG1418 Tandem pore domain K+ channel  ali  100  1MDVPTFILHSADTESVISDDDSSYYFDGSVEQLTLRNQEYSDDNRMQRRAPIRRKSALDDDQTSQAMKLLEKYIRKKYRHSVIFSQDSADIEQSSTPVGHTQSACQFSRNLTPEQRNGFYSTPLGPAPSEYHFPPGSPQFRESTIREEFKQQYRETWGHWFVRVGKFLYKLLGIQYMLLALMILGYACLGGYIFLTLEYDQQQLDLEVEKQVRLSESTLLAENLLKYLKQWNCGQSNENRCLELITKAFIERSIKVERDIRGEGWRYGNLACKTNLGRVATIIYGLIGIPLMLFVLKIFGEHSIKWAQKVRYSIRRCVKRCFRRSKLKRASTIESVASDEMPCEESGISEDEEQITTFPVKWALFIVFFFMVVCSLIVSFWEKWDFLTAFYFFFVSLSTIGFGDVIPEHPRTACGNGLLEIKICYISVMINGALKMSGDAVNFPRFLNTKIQLTEKFQLYLISALFVLYFVGLALFSMVYAILQERVENQYMWALELIDQEYQENQKQDPDDHLEIPTILPENAAGMEGWTNTIGKMVSQNPVRWRAKNSAYSMENMPDRPISERRFSVLSPGEAPQAPPPVLGTFMLHSLSVKKKLLARSESILNRTGSPWPHAAEMNRPKEATRLGEPSALRVSAPNLTISGGNRSPSGGALSVITEASDEDTRHFKKHRRPLAKTVSTDGTVSNHGSAESLDQVMDELQLESHDQAVTPKPYRDPTTSTRFRKRDETVVSRAEKMPLSPNEVLEEEDEDENGDT 757
2 -51.400[P] KOG4404 Tandem pore domain K+ channel TASK3/THIK-1  ali follow..  15  12.......................................................................................................................................................................HLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSCHQRQLRRRGALPQESLK--------DAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHFANFVFILMGVCCIYSLFNVISILIKQSLNWI......................................................................................................................................................................................................................................................................................................................... 290
3 -14.300[P] KOG0501 K+-channel KCNQ  ali follow..  7  327.........................................................................................................................................................KVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLA-ACIWYSIGDYEIFDEDTKTIR--------LYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQM-TNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLVFKEHPAFRLASD-GCLRAL---AMEFQTVHCGDLIYHAGESVDSLCFVVSGSLEV-----IQDDEVVAILGKGDVFGD-AQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQEL 943
4 -13.700[P] KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes)  ali follow..  9  103.SSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTAASSTTFPKANKRKNQNIGYKLGHRRAPFEKRKRLSDYALIFGMF------GIVVMVIETEKDSMFSLALKCLISLSTIILLGLIIAYHTREAQLFVIDNGADDWRIAMTYERILYISLEMLVCAI---HPIPSYTPSRAEADVDIILSI-PMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTIC-------------------PGTVLLVFSISLWIIAAWTVRACER-NFLGAMWLISITFLSIGYGDMVPHT---GVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSS........................................................................................................................................ 730
5 -12.700[P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component  ali follow..  21  5..............................................................................................................................................................................LFIRIGVIILCLILLFGQIIYILEPKQFTSVFEGI----------------------------------------------WWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFS.................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 89
6 -10.600[P] KOG4390 Voltage-gated A-type K+ channel KCND  ali follow..  11  171................................................................................................................................................................................................VWRAFENPHTSTMALVFYYVTGFFI--AVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVM-TVEY--AAPSR---RSVMSIIDVVAIPYYIGLVMTDNEDVSGAFVTLVFRVFRIFKFSRHSQGLRILGYTLKSCASEL-------------------FLLFSLTMAIIIFATVMFYAEKG-SIPAAFWYTIVTMTTLGYGDMVPKT-----IAGKIFGSICSLSLVIALPVPVIVSNFSRIY---HQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFEESCMEVATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAIISIPTPPVTTPEGDDRPESPEYSGGN................................................................................................... 623
7 -10.500[P] KOG3713 Voltage-gated K+ channel KCNB/KCNC  ali follow..  15  278.............................................................................................................................................RMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALLLLMYLAVGIFVFSALEQSHPETLFKSIPQS------------------------------------------FWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIH----PIINNFVRYYNKQRVLETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPA.................................................................................................................................................................................................................................................................................................................................................................................................................. 457
8 -10.400[PT] KOG0499 Cyclic nucleotide-gated cation channel CNCG4  ali follow..  10  55.........TKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCW-RLVFPYQTADNIH-----------------------------------------LIADIICDIIYLYDMLFIQPRLQGDIIVDS---NELRKHY-VASIPFDICYLFFGFNPMFRANRML--KYTSFFEFNHHLESIMDKAYIYRV-----------------RTTGYLLFILHINACVYYWASNYEGIGTTRWEYLRCYYWAVRTLITIG-GLPEPQTLEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVESDLLKTLPTTVQLALKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGDKKTLQEILVHYPDSERILMKKALKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLKREQAAQKKENSEGGEEEGKENEDKQKENEDKQKENEDKGKENEDKDKGREPEEKPLDRPECTASPIAVEEEPHSVRRTVLPRGTSRQSLIISMAPEEVLTIEVKEKAKQ. 809
9 -10.300[PT] KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins  ali follow..  7  1.....MAKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWY-RACFDELQSEYLM-----------------------------------------LVLDYSADVLYVLDVLVRARTGFGLMVSDT---NRLWQHY-VLSVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGN------------------VLYILIIIHWNACIYFAISKFIGFGTDSWKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY--------------------MQFRKVTKDLETR---VIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVR------------QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSGSKSGNRRTANIRSIGYSDLFCLSKDDLMEA--TEYPEAK--KALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQQ.... 694
10 -10.200[S] COG5373 Predicted membrane protein  ali follow..  11  19.............................................................GGRRSAERLDREIESLKAEIARLAKEGMGEPGPDLATGRPSEAGVPSVAGTEATADGPWSRAREGAGTSHDESAAGRESGDGAIDGPVAPSAAAARAESLESRIGGRW----PVWVGGLALA-----LGGYFL--VQYSIEAGLLSPAVRLTLAAIFGLA----EVIRRRDVPAIADRFRNAMIPGVLTAAGAVTLFGVVYAAYGYDFIGTGAAFVLLALVSLATVGLSLALAGLGLLASLLTPLF-----------------------------------------------SSGEPRPWVLFGFLAVAWLATLAASRLRRWSVVPTLANAGLGLWGLAYVALATPFEAPPVTFALLVMIAGVALIW........................................................................................................................................................................................................................................................................................................................................ 335
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. cd-hit: a fast program for clustering and comparing large sets of protein or nucleotide sequences. Bioinformatics. 2006 May 26;