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Query: [DL] KOG1434 Meiotic recombination protein Dmc1, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSVTGTEIDSDTAKNILSVDELQNYGINASDLQKLKSGGIYTVNTVLSTTRRHLCKIKGLSEVKVEKIKEAAGKIIQVGFIPATVQLDIRQRVYSLSTGSKQLDSILGGGIMTMSITEVFGEFRCGKTQMSHTLCVTTQLPREMGGGEGKVAYIDTEGTFRPERIKQIAEGYELDPESCLANVSYARALNSEHQMELVEQLGEELSSGDYRLIVVDSIMANFRVDYCGRGELSERQQKLNQHLFKLNRLAEEFNVAVFLTNQVQSDPGASALFASADGRKPIGGHVLAHASATRILLRKGRGDERVAKLQDSPDMPEKECVYVIGEKGITDSSDLast
1 -102.000[DL] KOG1434 Meiotic recombination protein Dmc1  ali  100  1MSVTGTEIDSDTAKNILSVDELQNYGINASDLQKLKSGGIYTVNTVLSTTRRHLCKIKGLSEVKVEKIKEAAGKIIQVGFIPATVQLDIRQRVYSLSTGSKQLDSILGGGIMTMSITEVFGEFRCGKTQMSHTLCVTTQLPREMGGGEGKVAYIDTEGTFRPERIKQIAEGYELDPESCLANVSYARALNSEHQMELVEQLGEELSSGDYRLIVVDSIMANFRVDYCGRGELSERQQKLNQHLFKLNRLAEEFNVAVFLTNQVQSDPGASALFASADGRKPIGGHVLAHASATRILLRKGRGDERVAKLQDSPDMPEKECVYVIGEKGITDSSD 334
2 -98.300[L] KOG1433 DNA repair protein RAD51/RHP55  ali follow..  46  4LTNVQAQQEEEEEEGPLSVTKLIGGSITAKDIKLLQQASLHTVESVANATKKQLMAIPGLGGGKVEQIITEANKLVPLGFLSARTFYQMRADVVQLSTGSKELDKLLGGGIETGSITEIFGEFRCGKTQLCHTLAVTCQLPISQKGGEGKCMYIDTENTFRPERLAAIAQRYKLNESEVLDNVAFTRAHNSDQQTKLIQMAAGMLFESRYALLIVDSAMALYRSDYIGRGELAARQNHLGLFLRMLQRLADEFGVAVVITNQVTASLDGAP--GMFDAKKPIGGHIMAHSSTTRLYLRKGKGETRICKIYDSPCLPESEAMFAILPDGIGDARE 335
3 -83.200[L] KOG1564 DNA repair protein RHP57  ali follow..  21  4..................SNYVDNFYFDEKIASAFELGEV-STVDLLTLDITELERRTHCSQSELLQLIEQISLLLQPVRCSASKVTSK-----YLTTGDVKLDETLHGGIPVGQLTEICGESGSGKSQFCMQLCLMVQLPLSLGGMNKAAVFISTESGLETKRLFELARYLPERYPKAGDRVYTILCPDLESQEHIIQYQPILFNRDKIGLVILDSVASNYRAELRDLDNIAKRGNQLGKLAMTLRTLAHQHEAAVVIANQVSDRIPRDYDDTDPNPKIPSLGLVWTNNISTRLALIKKNNSGRIFRVVYSPNSPRLDVRICIGSVGIYSC.. 354
4 -46.800[L] KOG2859 DNA repair protein, member of the recA/RAD51 family  ali follow..  15  1...................................................................MGDDEARSWIRGDETAKQMLSRVL----KDRAFLLIPPLHRVPLRAGNVVEITGASTSAKTQILIQAAISCILPKTYGGLGKLVLFLDLDCRFDVLRLSQMLKHRLLQYASCMKRFLYVRCYDSLELLSSLKTLHYRIQQQQVGVLMIDSIGAFHWTDRLSSSKSLSLTNVVETIVQELKKLLLVHSLVVLATKGTIYEEKYPA---NENNRRFISNFPKISGRSPQTTIFQGMLQVKLSNLHFVNSCLLLGRIYKISLIISKDDS. 312
5 -37.700[L] COG0468 RecA/RadA recombinase  ali follow..  21  1......................................................MAIDENKQKALAAALGQIEKQFGKGSIMRLG-EDRSMDVETISTGSLSLDIALAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQRE------GKTCAFIDAEHALDPIYARKLGVD--------IDNLLCSQPDTGEQALEICDAL---ARSGAVDVIVVDSVAALTPKGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGV----MFGNPETTTGGNALKFYASVRLDIRRIGAVKERVKVVKNKIAPFKQAEFQILGEGINFYGE 274
6 -27.200[NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella  ali follow..  16  8......................................................................................LEEEKKKNILSSGNGEIDKRLGGGIPLGSLTLIEGENDTGKSVLCQQFVYGGLMS------GHNIAYYTTEN--TIKSFLRQMESLSLDVSDFYAWGYLRVFWSTEQMRSILNLVANHIKTIRENIAIIDSLTMFT---------TYSTEDDVLEFLTRLKNLCDNGKTILITLHQHAFKEDTLVRI--------------RSACDCHLFLRKEQVGVSVLEVSKARKTTGNIVSFEVHPGGLK.... 235
7 -22.100[L] COG3598 RecA-family ATPase  ali follow..  14  351...............................................................................................WDNLPELAPELIKGVLRQGHKMLIAGPSKAGKSFALIELSIALAEGQKWLGWQGKVLYVNLELDRPSHRFKDVYDAMGLPPANVANIDIWNLRGKTVPMDKLAPKLIRRSLKKNYQAVIIDPIYKVLTGDENSADQ-------MAHFTNQFDKVATELGCSVIYCHHHSKGSQGGKKSMDR-----ASGSVFARDPDALIDLVELELTEDLIKARSEKAAAK................. 566
8 -19.900[T] COG0467 RecA-superfamily ATPases implicated in signal transduction  ali follow..  16  212....................................................EILKYRGTDHQKGEFPFTIINKKGIVIIPLSAIELEQKSSDIRITSGSEELDRMCGSGFFRDSIILVSGATGTGKTLMVTEFMDGGVAN------GERCLVFAFEE--SREQLIRNATGWGVDFKQMEKEKVVCRYPETTNLENHLIMMKDIIQEFKPNRVAVDSLSAL---------ERVSTLKSFREFIIGLTSFIKQQEIGGLFTSTTPNLLGGASITDAHI----------STITDSIILLRYVEMYRRGITVLKGSMHDKDIREFSIDHQGMH.... 470
9 -17.600[L] KOG2373 Predicted mitochondrial DNA helicase twinkle  ali follow..  274................LHYDASHSWDAARAFALKLDERRCLLIRPTETEPAPHLALR---RRLNLRHILAKATPVQHKAITTFGAMRNDEKVNGVKWKRFPVLNKLL-KGHRRGELTILTGPTGSGKTTFMSEYSLDLAMQ------GVNTLWGSFEIRNTRLAATLLRQYVGYPLDDRLHELYFMTFHGQQPLKPVLEAIEHASYVHDVMHVIIDNLQFM----MGVSTFRGDKFFEQDSIIAAFRSFATKHNVHVTLVMHPRKERQEDELTTSS-----FGTAKATQEADNVLIIQDKRRGKKYLQIAKNRYLGIMPLEFDKDGLSYSTQIQ 600
10 -15.900[O] COG1066 Predicted ATP-dependent serine protease  ali follow..  19  69........................................................................................SLQETPRFSSGFHELDRVLGGGVVPGSAILIGGHPGAGKSTLLLQVMCGL-------AQNMTALYVTGEESLQQVAMRA------KRLGLPTDKLNMLSETSVEQICQLADQLKP-------QIIVIDSIQVMHLADIQSSPGSVAQVR---ECASFLTRYAKTRQVAIIMVGHVTKDGTLAG-------------KVLEHCIDCSILLEGEASRYRTLRSHKNRFGAVNELGFGMTEQGLREVKN 281
11 -14.600[L] COG0305 Replicative DNA helicase  ali follow..  15  103..........KNTPSVSNIVSYAAIVRDRAILRDLISVSNDVAQSCYTTKGMEVKDILDEAERKVFAISEKRTTSNEGPQNICAILEKTIDRIELVSTGFDALDKKT-AGLQPSDLIIVAARPSMGKTTFAMNLCENAALKSEMPAEQIMMRSLASLSRVDQTKIRTGQGLDQSDWSKIGSNLYIDDSSGLTPTELRSRARRVYRENGGLSLIMVD-----YLQLMRAPGFADNRTLEIAEISRSLKALAKELEVPVIALSQLNRTLENRADKRPVNSDLRESGSIEQDADLIMFIYRSEDKGVAEIIIGKQRNGPIGRVRLAFRGQ....... 450
12 -14.100[S] COG4544 Uncharacterized conserved protein  ali follow..  18  53........................................................................................GSRNRSILPFGVPELDAQLGGGLAFGALHEVAGGGNGSIDGAAAALFIGGIAART----TGKVVWCLTRFDLFFPALAKV-----------PDRVIFVECYKEET---VLASFEEALRYGGLGAVVAEL------------------VRLPMTASRRLQLAAEKSGTLGLVIRRWRRQTEASD............................................................... 203
13 -11.500[D] COG5404 SOS-response cell division inhibitor, blocks FtsZ ring formation  ali follow..  15  6.........................................................................................YAHRSSSFSSAASKIARVTENTTAGLISEVVYREDQPMMTQLLLLPLLQQLGQQ----SRWQLWLTPQQKLSREWVQAS-----------LTKVMQISQLSPCHTVESMVRA---LRTGNYSVVIGWLADDL------------------EEEHAELVDAANEGNAMGFIMRPVSASSHAT................................................................ 155
14 -11.300[H] COG2087 Adenosyl cobinamide kinase/adenosyl cobinamide phosphate guanylyltransferase  ali follow..  15  3...............................................................................................................DKNRSVFILGGARSGKSRFAEELAGKA---------GGRLHYLATGRAWDDEMRDRISHHQERRGGE----------TTHEAPVDIATVLQRLDSPDSV--ILIDCLTLWLTNLMMENADMETAFAEL------EAAIVSTRAKLILVSNEV....................................................................... 128
15 -10.500[R] COG2842 Uncharacterized ATPase, putative transposase  ali follow..  15  1........................MTLINKLKQHLSDSQI---------TQAQLAREAGVNAGALSAYLNVEAKLAAYLEKKAVQAREFVEAPAFIETTSRQIFKTLEFAQIANCLATVYGMSGVGKTKAIQEFAKS----------HANVWLVTASPSRSSLSLYEIALELGISDAP--------------RRKGTLSRLIARKIKGTEGLLIVD-----------------EADHLPYEALEELRIMQEEAGIGLVLVGN........................................................................ 200
16 -9.870[BK] KOG3949 RNA polymerase II elongator complex, subunit ELP4  ali follow..  14  57.........................................................................................RNGQLLVSTGLPALDQLLGGGLAVGTVLLIEEDKYNIYSPLLFKYFLA------EGIVNGHTLLVDASKRMPQELIEASNWHGFFLPEKISSTLKVEPCSLTPGYTKLLQFIQNIIYERNILRIGIQNLGSPLWGDDICCAENGGNSHSLTKFLYVLRGLLRTSLSACIITMPTHLIQNKAIIAR------------VTTLSDVVVGLESFIGSERLIHIRQIPRLNNKDLAFKLKRKLFT.... 379

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.