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Query: [L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDPMESSSEQDIVEESQKLVDSLDKLRVSAASSSSNFKKKPIIIIVVGMAGSGKTSFLHRLVCHTFDSKSHGYVVNLDPAVMSLPFGANIDIRDTVKYKEVMKQYNLGPNGGILTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFTWSASGAIITEAFASTFPTVVTYVVDTPRSSSPITFMSNMLYACSILYKTRLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTATLANSLSLSLYEFYRNIRSVGVSAISGAGMDGFFKAIEASAEEYMETYKADLDMRKADKERLEEERKKHEMEKLRKDMESSQGGTVVLNTGLKDRDATEKMMLEEDDEDFQVEDEEDSDDAIDEDDEDDETKHYYLLast
1 -95.700[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali  100  1MDPMESSSEQDIVEESQKLVDSLDKLRVSAASSSSNFKKKPIIIIVVGMAGSGKTSFLHRLVCHTFDSKSHGYVVNLDPAVMSLPFGANIDIRDTVKYKEVMKQYNLGPNGGILTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEIFTWSASGAIITEAFASTFPTVVTYVVDTPRSSSPITFMSNMLYACSILYKTRLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTATLANSLSLSLYEFYRNIRSVGVSAISGAGMDGFFKAIEASAEEYMETYKADLDMRKADKERLEEERKKHEMEKLRKDMESSQGGTVVLNTGLKDRDATEKMMLEEDDEDFQVEDEEDSDDAIDEDDEDDETKHYYL 379
2 -77.200[K] KOG1534 Putative transcription factor FET5  ali follow..  21  2.......................................VKVAAFVCGVASSGKSTFCGALMSYMKSVGRSCHLVNLDPAAENFEWEPTVDIRDLISIDDVMEELDYGPNGGLIYCFEFLMENLDWLNEEIGDYDED--YLIFDMPGQIELYTHVPILPALIRHLQVTFRPCAVYLLESQFLVDRTKFFAGVLSAMSAMVMMEVPHINLLSKMDLLKDNNNITKAELKRFLNTDP-------LLLTGEINETTNPKFHELNRCIVQLIDDFNMVNFL-PLESGNEESVSRVLSYIDDATQWYEDQEPKDPDRFEADDLEDDE......................................................... 276
3 -76.500[R] KOG1533 Predicted GTPase  ali follow..  17  2.........QMNLNEKKQLLRVRVYATSEKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNGALKYCIETLGANCNWLLQKIEANHKK--YLIIDCPGQLELYKSEGELWKVIRFLEKGVRLCALHLADSLYCSDPSKFISVALSTLATMVTMEMPQVNCLSKADLFSEDGTYDLEFFSHLPDVNRLLDLLNEVP--------GLEKYRKLNEAICGVISDFDLVSFV-PLAVENKESMMKVIQMVDAANGFSLTEQGDIRELILNS............................................................... 298
4 -17.600[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  16  2......................................KRPLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAAITNDIYT-------KEDARILLNTSVLPADRIAGVETGGCTAIREDASMNFAAIEEMCDKHPDLQLLFLESGGD-----------NLSATFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSDLF---------IINKVDLAP-----------------------YVGANVEVMKADTLKSRGNKDFFVTNLKTDEGLKSVADWIEKRLQLALLE......................................................................................... 205
5 -14.600[R] COG1341 Predicted GTPase or GTP-binding protein  ali follow..  16  1MMRMASNKAMFTNDVPQDRLLAVEKIESLRKPAK---------VMIIGDVDTGKTTLTIYLANELLSRGFRVAIIDSDIGQKGILPPATISLA-------FVDSHFTSLD-GTITPNQYFGEMVVGVMKLSELAMKFSDVVLIDTTGMIY-----GSGVELKRMKIEAVKPNLILALER........................................................................................................................................................................................................ 167
6 -14.300[D] COG2894 Septum formation inhibitor-activating ATPase  ali follow..  13  3........................................RIIVVTSGKGGVGKTTSSAAIATGLAQKGKKTVVIDFDIGLRNLDLIMGCERRVVYDFVNVIQNLYILPASQTRDKDALTREGVAKVLDDLKAM--DFEFIVCDSPAGIE--------TGALMALYFADEAIITTNPEVSSVRDSDRILGIL........................................................................................................................................................................................... 160
7 -14.200[R] KOG2486 Predicted GTPase  ali follow..  16  96.TRILKGSNIVLSKYARDAQVVQADYVKSSVKTEDCPADGLPEFALVGRSNVGKSSLLNSLVR-----RKRLALTSKKPGK-----------TQCINHFRI-----------------------------------NDKWYLVDLPGSAPHELKQDWNKFTKDYFLNRSTLSVFLLVDASIPVKPID-----LEYASWLGQNQVPMTLIFTKCDKRKKKKNGG-----KKPEANIKEFQDLIQGFFETTPPWI----------MTSSVTNQGRDEILLHMAQLRNYWLKH......................................................................................... 318
8 -13.900[P] COG1348 Nitrogenase subunit NifH (ATPase)  ali follow..  12  4...........................................VAIYGKGGIGKSTTTQNLTSGLAELGKKIMVVGCDPKADSTRLDTLREEGEDVDLDTIMKTIKCVESGGPEPGVGCAGRGIINMLEQLGAYEDELDYVFYDVLGDV-----VCGGFAMPIREGKAKEIYIVASGEMMAMYAANNISKG-ISKFANTGGVRLGGIICNSRLEAFAKELGTQLIYFVPRSHEVQKAEINKQTVIQFNPKDEQADEYRALAKAIDG................................................................................................................. 246
9 -13.500[D] COG0455 ATPases involved in chromosome partitioning  ali follow..  11  1MNLITGPVIQRDSRRRTGMTNKMIYDQASGLRRLTQPSVTKVISVTGGKGGVGKSNVTLGMAICMAKQGKKVMVLDADLGLANVDIRPKRNLGHVLELKDAIVEGPHGPATGTQSMTELSHAQHVGLIRAFGTLEDEMDILLIDTAAGIS--------DMVVSFSRAAQDVVVVVCDEPTSITDAYALIKLLFKIVANMVRSYREGRELFAKLTLVTERFL-CIPLDDNVRQAVKRQKIVVDAYPRSPAALAISSLANKALTWPIPRTPSGHLEFFVERL................................................................................................... 300
10 -13.400[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  15  23.........AQAMTLVESRHPRHQALSTQLLDAIMPYCGNTLRLGVTGTPGAGKSTFLEAFGMLLIREGLKVAVIAVDPSS---PVTGGSILGDKTRMNDLARAEAAGHLGGASQRARELMLLCE---------AAGYDVVIVET-GQSET---------------------VARMVDCFISLQIAG-GGDDLQGIKKGL-MEVADLIVINKDDGDNHTNVAIARHMYESALHILRRKYD------------------QPRVLTCSALEKRGIDEIWHAIIDFKTALTASGRLQQVRQQQSVEWLRKQTEEEVLNHLFANEDFDRYYRQTLLAVKNNTLS....................................... 313
11 -13.400[D] COG3640 CO dehydrogenase maturation factor  ali follow..  18  9...........................................LIISGRGGSGKSTLVTLIAHTLKEQKKRVLVVDSDESNIGLSGILGIEFREKFDLESLSQEFVCWVGSLGLMQIGKIDHATRDFLNHVRL--EEDQWVLVDTEAGVE-----HFGRGIVEGADA-----VVMVVDPSSDA-----VLLAEKAAKLTHEADKRFGVILNKID..................................................................................................................................................................... 206
12 -13.100[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  19  52.....................................RTKSNTVLLSGLSGSGKTVLFYQLR---DGSSHQGAVTSMEPNEGTFVLHNENNTKK----------------------------------------GKVKPVHLIDVPGHSRLISKLEEYLPRAAAV--------VFVVDALEFLPNIRAASEYLYDIASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAISTADIAEVFSFSHCHNKVTVAEASGLTG-ETDQVQEFIRE................................................................................................. 256
13 -13.000[A] KOG2749 mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1  ali follow..  17  101............................VTSSTRDSASSQGPRVIIVGDIDSGKSTLAKMLLNWAVKDGWKPTFVDLNVGQSSITIPGTIAAAPIKM-LDKALIHYFGPSVNLRLYRTLVEELARELKEEFSANAESRA-MVIDTMGFIV-----REGYALLLHAIRTFNASLVIVVGQ........................................................................................................................................................................................................ 258
14 -13.000[R] COG1084 Predicted GTPase  ali follow..  21  165...........................................VVIAGFPNVGKSTLLRTL-------------TGAEPEVADYPFTTKGIQIGHLERKW-------------------------------------KRIQVIDTPGLLD--DMNNIELQAMVALENI-ADVIMFIFDAS--TCGYTLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLEEYINMVE------------------------------DPLKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV.................................................................................... 336
15 -12.700[E] COG4917 Ethanolamine utilization protein  ali follow..  16  4...........................................IAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFNDKG-------------------------------------------------------------DIDTPGE---YFNHPRWYHALITTLQDVD-MLIYVHGA---NDPESRLPAGLLDIG----VSKRQIAVISKTDMPDAD--------------------------VAATRKLLLETGFEEPMFELNSHDPQSVQQLVDYLASLTKQ............................................................................................. 148
16 -12.600[R] COG0523 Putative GTPases (G3E family)  ali follow..  15  7...........................................TLLTGFLGAGKTTLLRHILN--QHGFKIAVIEN----------EVSVDDQLIGDRATQIKTLT---NGCICCTRS-LEDALLDLLDSRDRGDIAFDRLVIECTGMAD----------IIQTFFSHDVLCERYLLDGVILVDAVHANEQMNQFTIAQSQIGYADRILLTKTDVAGDSEKLR............................................................................................................................................................ 170
17 -12.300[R] COG3596 Predicted GTPase  ali follow..  14  1MVMKNFEVLQPLQNSLSGLPLWVSERILQQINQLTHYEPV---IGIMGKTGAGKSSLCNAL------FAGEVSPVSDVAACT----------RDPLRFRLQIGEHFM---------------------------------TIVDLPGVGESGVRDTEYAALYREQLPRLD-LILWLIKA---DDRALATDEHFYRQVIGEAYRHKMLFVISQSDKAEPTSGGN------------ILSTEQKQNISRKICLLHELFQPVHPVCAVSVRLQWGLRVMAERM................................................................................................... 212
18 -12.200[H] KOG2743 Cobalamin synthesis protein  ali follow..  13  1MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIIGYLGAGKTTLLNYILT--EQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLE-----RNGCLCCSVK---DNGLRAIENLMQKKGKFDDILLETTGLAD----------VASMFWVDAEL-IITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRV...................................................................................................................................... 237
19 -12.200[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  18  171...........................................VLICGYPNVGKSSFMNKVT-------------RADVDVQPYAFTT--------------KSLFVG---------------------------KYLRYQVIDTPGILD-FEDRNIIEMCSITALAHLRAAVLFFLDSGSCGYTIAQQAALFHSIKSLF-MNKPLVIVCNKTDLMPMENISE-------------EDRKLIEEMKSEAMKTAMGASEEQVLLKMSTLTDEGVMSVKNAA................................................................................................... 345
20 -12.100[A] COG5623 Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1  ali follow..  11  83LLWKCPDLTTNTITVKPNHTMKYIYNLHFMLEKIRMSNFEGPRVVIVGGSQTGKTSLSRTLCSYLKFNAYQPLYINLDPQQPIFTVPGCISATPILLHNKQPMVKNFG-LERINENKDLYLECISQLGQVVGQRLHLDP-CIVDTPSISQ----LDENLAELHHIIEKLNVNIMLVLCSETDPLWEKVKKTFGPELGNNNIFFIPKLDGVSAVD..................................................................................................................................................................... 317
21 -12.000[T] KOG3886 GTP-binding protein  ali follow..  15  1MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKK--VLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFD--------------------VEHSHVRFLGNLVLNLWDCGGQ-DTFMENYFTSQRDNIFRN----VLIYVFDVE-LEKDMHYYQSCLEAIL-QNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQ.............................................................................................................. 246
22 -11.900[R] COG2229 Predicted GTPase  ali follow..  19  2.......................................RENKIIFTGPVGVGKTTAIAAISD-----------------------------EALVQTDASASDMTLDRKRNTTVAMDYGAISLD----------EDTKVHLYGTPGQ-ERF------NFMWEILSQGSMGLVL-LLDNAR-TNPLKDLEFFLHSFRGLLE-KAPVVVGITKMDIRSQPG-------------------------IDVYHKYLAKHNLNVPVFEIDARKEDDVKQLVSAMLFSIDPGLE.......................................................................................... 177
23 -11.800[F] COG1618 Predicted nucleotide kinase  ali follow..  14  4..................................EGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGGIRTAEIRKEGHREGFSIRDLATGKTGILSHVK-GSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIGPMELIS-QSFVSAVEEVLESDKPVLAVLHHSSRHPLAQRFRKGFEVLTVDKGNRDELPE-KITNRF...................................................................................................................................................................... 179
24 -11.700[R] KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein  ali follow..  15  308.................ITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPG------QPEVVPSGHISLYYINSPL-QGPVGDIIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIR-----GGGAELLSSIVDICQPTEVVYMSRE....................................................................................................................................................................................................... 482
25 -11.500[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  1MAGGEAGVTLGQPHLSRQDLTTLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISG-----------VHTVRFKNELERNITIKLGANAKIYQLDDPSCPRPECYRSCGSSMPDEFPTDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMD--------AALLLIAG----NESCPQPQTSEHLAAIEIMKLKHLILQNKIDLVKERQAKEQYEQILAFVQGT--------------------VAEGAPIIPISAQLKYNIEVVCEYIVKKPRDFTSEPRLIVIRS................................................................................. 261
26 -11.200[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  17  95...........................................ILLVGQYSTGKTTFI----RYLLESDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVDAKK-QFRALSGFGNAFLNRFQ-VLESVT---------IVDTPGILS-YDFTGVLEWFAERVD-----RIILLFDAHKLDISDEFKRCIEALAGNEDKIRI----VLNKSDMVDHQQLMR............................................................................................................................................................ 265
27 -11.200[R] KOG0395 Ras-related GTPase  ali follow..  18  1......................MMKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLN---------------------QYTPTIE---------------------------------DFHRKVYNIRGDMYQLDILDTSGNHPFPAMRRL------SILTGDVFILVFSLDNRESFDEVKRLQKQILEVKSCLK-ELPMVICGNKNDHGELC-----------------------RQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVL................................................................................................... 186
28 -11.100[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  12  23.DELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNE----TLFLESTNK-------------ICREDV-------------------------------SNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTG-----ALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIHSIFEAFSKVVQKLIPQ--LPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDM.......................................................... 289
29 -11.000[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  19  344.............................................LIGLPNAGKSTILNKIS-------------NAKPKIGHWQFTT------------------LSPTIGTVSLGF-----------------GQDVFTVADIPGIIQASLDKGMGLEFLRHIERS---GWVFVLDLS-NKNPLNDLQLLIEEVGTLEKVTKNILIVCNKVDIDAEKSESF............................................................................................................................................................ 472
30 -11.000[R] COG4240 Predicted kinase  ali follow..  12  48FNQFCQNNLKIPPEQMFPVLWDLWLPLGMKIAAQHQQLKRPFIQGILGSQGTGKTTMSLVIQLILQHLGYRTLSLSLDD------YKTYSDRLVLLQQDPRLIWRGP-PG----------THDIDLGLNVLEQIRQGKSPV------IVPRFDKSAHAGAGDRTKPDVITGVDILIFEG-----------FVGVRPIDPSLFNFPPSPILTDEDKAFARDMNLRLNHYLPLWEKLDSLILLYPTDYRCSLEWRKQAEQKMIAAGKTGMSNTQIEEFVNYF................................................................................................... 295
31 -10.900[D] KOG3022 Predicted ATPase, nucleotide-binding  ali follow..  12  32.............PNQEACATAPKGPDPDLVAIAERMSTVKHKILVLGKGGVGKSTFSAQLSFALAGMDHQVGLMDIDICGPSIPKMLGLEGQEIHQSNL-LGVMSIGSDEAVIWRGPRKNGLIKQFLKDVY---GEIDYLVVDAPSDEHI--------SIVQYLLPTGIDGAIIVTTPQEVS-----LIDVRKEVSFCKKVGVPVLGVVENMS..................................................................................................................................................................... 235
32 -10.800[P] COG0370 Fe2+ transport system protein B  ali follow..  17  2.......................................SQNTYCILGNPNTGKTSLFNALT------GSYEYVGN--SGVT---------------------------------------------VEKKVGTLRSKTGKLIDLPGIYDLNPISRDETVVTRFLLEEKFDCMLNIVDSSQ-------IERNLNLTVQLLEYGAPVVMGLNMIDVAAGRGI--------------------------HLNIQNLAKKLRIPILPVVARSGKGTEDILSTLSEKHVAPAIPLVLQYGEPA--------EKAIKEIQALTKELIPAKQSRWLAIQFLSKNEVTEAFLTSNSAFEQLQQIRAELESELNGKLENHFHQVRA. 247
33 -10.600[U] COG4963 Flp pilus assembly protein, ATPase CpaE  ali follow..  11  2...............................VDPEAEPLGRNIAFIGAKGGVGSSTIAHNCAFGISSLSTETILADMD-ANIDFDQDPAQGMAEAVFSPERLDEVFLCSDHLSLLA-RTYDLDRQAFLPILEVLQRSAPVAVLDLPHQWC--------DWTRAVLAEADEVVITAVPDLANLRNTKNLFDALIKLRPNDKLPHL----VLNQVG..................................................................................................................................................................... 188
34 -10.600[R] COG0536 Predicted GTPase  ali follow..  19  164.............................................LVGFPSAGKSSLISVMS-------------AAKPKIGDYPFTT------------------LQPNLGVV-------------------NVGHETFTMADVPGLIPASEGKGLGLDFLRHIERT--SVLVHVVDTALEAELAAYQSALDEDTGLGDLSQRPRLVVLNKADVPEAEELAEFLKED--------------------------EKQFGWPVFIISAVARKGLDPLKYKLLEIVQDARKK......................................................................................... 346
35 -10.400[R] KOG2878 Predicted kinase  ali follow..  10  2.................SSLEIIVDKILKFLEKQPKPEGRPFILGISGPQGSGKSTLASALDTELTRKNESVVKFSLD----YLTHAEQVELAKNNPNNPLVQHRGL-AG---THDVTFLNNVLNAFVKGSDEE--------VSIP-DKSKFGGYGDRGDESQWKKANPKTTTYVIFEG------------VGFEPLDSCMLSVRARSTRWQNIEGSLLWVNRKLADYQPIFQKIDSLVELEAQEINYVYRWRLQQEHALKARIHKGMSDEEVIEFVNHYMPQYVFYLGTLSNKVH................................................................................... 257
36 -10.400[R] COG0218 Predicted GTPase  ali follow..  18  28...........................................IALAGRSNVGKSSFINTMLN-----RKNLARTSGKPGKT----------------------------------------------QLLNFFNIDDKMRFVDVPGRVSKKEREKWGCMIEEYLTTRENLAVVSLVDLRHDPSADD-----VQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKL----------------------NFDPSDDFILFSSVSKAGMDEAWDAILE................................................................................................. 193
37 -10.300[U] COG0552 Signal recognition particle GTPase  ali follow..  14  86......QDPKEVQSVISEKLVEIYNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDGAIEQLEV-------ERTGVPVIKQTAGSDPAAVIYDAVH-------------AAKARNADVLICDTAGRLNLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVT---------ALTKLD..................................................................................................................................................................... 276
38 -10.300[R] COG5258 GTPase  ali follow..  12  67LREMARRVGASLYILRVSEGIRGKVAEVLLRAVSREEPPPTVTVVALGNVDAGKSTLVGVLTT-----------GRLDDGK-----------LARSYASRYKHEVLTGRTSAVSLRLLGFSGDKVVNHGLIDPLDSDKLVLLVDVGG------HERYLRTALRGLFSSQPDYVMLVVAANSGVQKMT--------LGIAVAIGIPVFVVVTRIDITPSEVFQKTVEEVVRILKMPGVSKIPYIIKDTNDVVLAAKAMPAGRVAPVSSVTGHGLDLLLRFLSLRRWDYGGEFLMYISDI................................................................................. 346
39 -10.300[J] KOG0469 Elongation factor 2  ali follow..  15  24.............................................VIAHVDHGKSTLTDSLVSKAGIIAG-----SKAGETRFTDTRKDEQERC-ITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYNGFLINLIDSPGHVDFSSEVTAALRVTD---------ALVVVDC---------VSGVCVQTETVLR-RIKPVLFMNKMDRALLELQLGAEELFQTFQRIVENINVIIATYGDDDGPMGPIMVDPSIGNVGFGSGLHGLKQFAEMYAGKFGVQVDKLMKNL.................................................................................... 258
40 -10.200[P] COG0003 Oxyanion-translocating ATPase  ali follow..  13  4...........................................ILMTGKGGVGKTSVAAATGLRCAELGHKTLVLSTDPA-HSLADSFDLELHEPRLVKENLWGAELDALMELEGNWGAVKRYITQVLQARG-LDGVQAEELAILPGMDEIFGLVRMKRHYDEA---------VLIIDSAPTGTALRLLSVGGWYMRRFYKPLQGMSVALRPLVEPLFRPIAGFSLPDKEVMDAPYEFYEQIEALEKVLTDN-----TQTSVRLVTNPEKMVLKESLRAHAYLSLYNVSTDLVIANRILPETIDDPFFQRWKSNQQ............................................................... 267
41 -10.200[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  18  32........KARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLA-------------GVYSEVAAYEFTT------------------LTTVPGVIR--------------------KGAKIQLLDLPGIIEAKDGKGRGRQVIAVARTC---LILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNI-GFKKKDK.................................................................................................................................................................... 186
42 -10.200[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  14  2...............NTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLEDQLSSLHNDSK--RHGTQGEKLDLALLVD--------GLQAEREQG------ITIDVAYRYFS---------TEKRKFIIADTPGHEQYTRNMATGASTCE--------LAILLIDARKGVLDQTRRHSFISTLLGIKHL----VVAINKMDLVD-------------------YSEETFTRIREDYLTFAGQGNLDIRFVPLSALEGDNVASQSESMPWYSGPTLLEVLETVE................................................................................... 236
43 -10.100[R] COG1163 Predicted GTPase  ali follow..  15  68...........................................VGFVGFPSVGKSTLLSKLT-------------GTESEAAEYEFTT------------------LVTVPGVIR--------------------KGAKIQMLDLPGIIDAKDGRGRGKQVIAVARTC---LLFIILDVNKPLHHKQIIEKELEGVGIRLNKTPPDI-LIKKKEK.................................................................................................................................................................... 187
44 -10.100[D] COG0489 ATPases involved in chromosome partitioning  ali follow..  11  62...........AVDSPRSSFAETLRNVKLTADVVIQERQCRVIGVISCLPNEGKSVVALNLAGLIASTGKRTLVVDADPGLSRLTTRQSAGLVEVVPWTQAVKVDTRTAHSS-----ELLSS--SGMRKFIDSAREACDYIIVDLAPVVPV----IDAKAFAPQVDG-----FVFVTEWGKTPI-----QMVQNLMANEPQIANKTLIVLNKTDM.................................................................................................................................................................... 266
45 -10.100[D] COG1192 ATPases involved in chromosome partitioning  ali follow..  16  1.......................................MAKIISTVNMKGGGKTTLTVNLATCLAKYQKRVLVLDLDSQISAT--YSKLDIFDIIPEICQIEGLELIPGDIELYDEYLVSEKLHQIKEMLAPVLEEYDFVILDCAPGYNLLT--------RSGIAASDFYLLPARPEPLSVVGMQLLERRI........................................................................................................................................................................................... 198
46 -10.100[P] KOG2825 Putative arsenite-translocating ATPase  ali follow..  12  22...........................................IFVGGKGGVGKTTTSCSLAIQMSKVRSSVLLISTDPAH---------NLSDAFGTKFGKDARKVPGFDNLIDPNLSIQEMTEQADQQNPNNPLSGMMLAFTIPGIDEALAFAEILKQIKSM---------CVIFDTAPTGHTLRFLNVLEKALGKLGGLSSRFGPMINQMGSIMGVNANE-----QDLFGKMESMRANISEVNKQFKNP-----DLTTFVCVCISEFLSLYETERMIQELTSYEIDTHNIVVNQLL................................................................................ 261
47 -10.000[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  22  10.............................................IIAHVDHGKTTLVDKLLKLSGTLD-----------------------RKEAESERVMDSNDQEKERGI--TILAKNTAIKWNGYNIN---------IVDTPGHAD-FGGE---------VERVMSMVVLLVVDAQDGPMPQT-----RFVTQKAFKAGLRPIVVVNKIDRPGAR................................................................................................................................................................ 136
48 -9.960[M] COG0481 Membrane GTPase LepA  ali follow..  20  9.............................................IIAHIDHGKSTLSDRLIQTCGG------------------------LSDREMEAQVLDSMDLERERGITIKAQSVTLNYK------AKDGETYQLNFIDTPGHVDFSYEVSRSLAACE---------ALLVVDAGQGVEAQT-----LANCYTAIEMNLEVVPILNKIDL.................................................................................................................................................................... 135
49 -9.960[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  18  14.....................................KKEQYSILILGLDNAGKTTFLETLKKEYSLAFKA--LEKIQPT--------------------------VGQNVATI------------------PVDSKQILKFWDVGGQESLRSMWSEYYSLCHGI--------IFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISA--------------------RDSRVLPISALTGEGVKDAIEWMIVRLERNKKS......................................................................................... 192
50 -9.920[F] COG1435 Thymidine kinase  ali follow..  9  1.......................................MAQLYFKYGTMNSGKSIEILKVAHNYEEQGKPVLLMT-----------SSLDTRA--GVGTVASRIGMKAEAVAI-------DEEMSVFDYVNSLPAKPFCVLID---EAQFLN-KKHVYDFARVVDELNVPVMAFGLKNDFRNELFEGSKYLLLLADKIEEIK................................................................................................................................................................................ 140
51 -9.900[S] COG4185 Uncharacterized protein conserved in bacteria  ali follow..  12  2..............................SIVRLKKLEQPVFLIVAGPNGSGKSSVYANADL--ELEGRSVWIVNPDLLAGRISIQSSISVHKTIGVETVLSTDKY--VGFAIWLFYTVLDSPERSIERIKLRVAKGGHDV---PADKVRARYARSLDQLPWFLE---------RADRAWIWDNSGATPKLIGEKQ...................................................................................................................................................................................... 182
52 -9.840[R] COG1159 GTPase  ali follow..  23  11...........................................IAIVGRPNVGKSTLLNKL------LGQKISITSRKAQTT----------RHRIV--------------GIHT-------------------EGPYQAIYVDTPG-LHMEEKRAINRLMNKAASSSIG-LVIFVVEGTRWTPDDEMV------LNKLRDGKAPVILAVNKVDNVQEKVDLL------------------------PHLQFLASQMNFLDIVPISAETGMNVDTIAGIV................................................................................................... 169
53 -9.800[R] COG4639 Predicted kinase  ali follow..  9  11...........................................VVLIGASGAGKSTFARKHFQ-------PFEVISSDFCRGLVENSQSASRDAFDVLHYITTKRLAAGKLTVIDATNVQPEDRKTLLQMAKQYHCFTVAIVFDLPEEL...................................................................................................................................................................................................................................... 112
54 -9.710[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  19  428VAPGPGSEGASATLCKNAGRALIRMISSSKAPEEEDEFDIMGKVIMLGDSGVGKTSLLIRFRDGRYVPSYFLSTVGIDFRNKVV----VVD-GTRVKLQ------------------------------------------IWDTAGQ-ERF------RSVTHAYYRDAHALLL-LYD---VTNKTTYIRAWLGEIREYAQEDVVIVLIGNKADCSGSERQVK---------------REDGERLGREHNVPFME---------TSAKTGLNVELSFTAVARQLKSRGYEHGDDGKFNVHDFVRDNTKARS.................................................................... 658
55 -9.700[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  21  65...........................................VALIGFPSVGKSTLLTMLT-------------GTHSEAASYEFTT------------------LTCIPGVIH--------------------NDTKIQLLDLPGIIEASEGKGRGRQVIAVAKSS---LVLMVLDASKSEGHRQILTKELEAVGLRLNKTPPQI-YFKKKKT.................................................................................................................................................................... 184
56 -9.680[NU] COG2874 Predicted ATPases involved in biogenesis of archaeal flagella  ali follow..  9  38...........................................TLIEGENDTGKSVLCQQFVYGGLMSGHNIAYYTTENTIKSF--SLSLDVSDFYA-WGYLRVFPVHLE-GIDWSTEQMRSILNLVANHIKTIREN--IAIIDSLTMFTTYSTEDDVLEFLTRLKCDNGKTILITLHQHAFKEDTLVRIRSACDCHLFLRKEQVGDRYVSVLEVSK.................................................................................................................................................................. 212
57 -9.620[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  10  75...........................................LLLYGPPGTGKTSTILAVARKLYGPKYRNMILELNASDDR-----GIDVRQQI--QDFASTQSFSLGKS------------------------SVKLVLLD---EADAMT-KDAQFALRRVIEKYTKSTRFALI----GNHVNKIIPALQSRCTRFRFAPLDGVHMSQRLKHVIEAERLVVSDC------GLAALVRLSNGDMRKALNILQSTHMASKEITEEESKQITEEDVYLCTGNPLPKDIEQISHWL.................................................................................... 282
58 -9.490[U] KOG0780 Signal recognition particle, subunit Srp54  ali follow..  13  79..................IFKELCRMLDPGKPAFAPKKAKPSVVMFVGLQGAGKTTTCTKYAYYHQKKGYKAALVCADGAFDQLKQ-----NATKAKIPFYGSYTESDPVKIAVEGVDRFKKE-------------KCDLIIVDTSGRHKQ-------ASLFEEMRQVAEATVIFVMDSSIGQAAFE-VGAVIIALSAVAATKSPFIGTGEHMDEFEVFDVKPFVSRLLGKGDWSGLVDKLQEVVPKDLQNELVENLSQ---------GNFTLRSMYDQFQCSLRIPLNQLFSMLPGISAEMMPKGHGEESRV.................................................................. 370
59 -9.430[N] COG1419 Flagellar GTP-binding protein  ali follow..  20  175...........................................VLFVGTTGVGKTTSLAKLARFKIDEKKRVAILTLD------TYR--------IAAAEQLKIY-----ADIMDIPMKIAYTPKEAEYEMMALK-DYDIVLVDTAGRSH--QNDLQMSELRALSEAVKPNITFLVLSMNYKLDDMKRIVERFSAVKP----------ILTKMD..................................................................................................................................................................... 317
60 -9.430[P] COG0529 Adenylylsulfate kinase and related kinases  ali follow..  23  1......................................QKPAVLWFTGLSASGKSTIANRLEQRLHALGKHTYLLDGDNVRHGLNSDLGFSDAD--NIRRVGEVARLMADAGLITPVSFISP-FREERDQVRARLPEGEFIFIDTPGEIKAFT.................................................................................................................................................................................................................................. 135
61 -9.350[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  8  49..............ATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAM------LWDKVLPSGIGHITNCF-TEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRVFWPKAK--CALLRD-----DLVLVDSPGTDVTTELDSWIDKFCLDAD-----VFVLVANSTLMNTEKHFFHKVNEWLSK-------IFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVANALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKKQILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANKVSCAM 413
62 -9.320[R] COG0645 Predicted kinase  ali follow..  12  1........................................RFLAVTHGVSAVGKSQVAMRLVERLRSDIERKRLFGEQPEHDRGQYSSQASEATYAHLHQLAAKILQAGYPVVIDAAYLKQNQRQAACHIAEETGVPFLILDCQAPEAVEGKDPSDATLDVIRTQQATRETVQSKRVDTHDAASLDGLVDGIRQRLPGL.................................................................................................................................................................................... 185
63 -9.260[R] KOG0394 Ras-related GTPase  ali follow..  19  2..................................PSRRRTLLKVIILGDSGVGKTSLMNQYVN--KFSNQYKATIGADFLTKEVQFE-----DRLFTLQ------------------------------------------IWDTAGQ-ERFQ-----SLGVAFYRGADCCVLVYVNSMKSFENLNNWREEFLIQASPSDPENFPFVLIGNKVDVDDGNSR----------------------VVSEKKAKAWCASKGNIPYFETSAKVGTNVEEAFQCIAKDALKSGEEEELYLPDTIDVGTSNQQRST..................................................................... 202
64 -9.220[C] KOG3877 NADH:ubiquinone oxidoreductase, NDUFA10/42kDa subunit  ali follow..  9  73...............................KTSKRFDENSKVICVEGPIAAGKSKFAKELAEELDMEYYPAVDLD-LIYINSY------DMRKLDPQSYDVRNFCLDPSHAAQFQIRMYMLRYSQYIDALQHVLSTGQGVVLE---SDFVFMEAMFRQGYLSR------------GARSVYNELRQNTIGELLKPHLVIYLDLPVDAVKKQIKARNVDY------------------EVQSKVFSDAYLSDLEQLYKQQ------YLKDISTHAELLIYDWTAGGETEVVVEDIERIDFNQFEADIHNKKMLDWRFPLEAEWCEARIKYCHEKPDLMNYFNVPRFDVPELVRSADDGKVWRDVWFN............ 376
65 -9.170[F] KOG3079 Uridylate kinase/adenylate kinase  ali follow..  11  21..........................TRRPILLCSPRLMKPLVVFVLGGPGAGKGTQCARIVEKYG-------YTHLSAGE----------LRDERKIEKYIKEGKIVPVEITISLLK------REMDQTMAANAQKNKFLIDGFPRNQD------NLQGWNKTMDGKADVSFVLFFDCNNEICIERCLESLEKRIQTYLQSTKPIIDLYEEMGKVKK................................................................................................................................................................. 206
66 -9.110[H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein  ali follow..  18  6.............................................ITGWKNSGKTTLTEKLVAELVRRGWKVSTVK------HAHHDFDIDKPG----ADSFRHRQAGATEVAIVSGNRWAGEDEPPLESILSRLAPCDIVLVE--GKIETRRLEAKDRTPLSAGDPNIVAIALPAFDLDDVKSIVDFIERTTGLVA...................................................................................................................................................................................... 167
67 -9.110[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  16  47.............................................IVAHVDHGKSTLADRLLEMCGAVPPG---------------------------KQMLDKLQVERERGITVKAQTAALRHRGYL-------------LIDTPGHVD-FSAE---------VSRSLAVCILLLVAANQGVQAQT-----IANFWLAFEKNIQIIPVINKIDL.................................................................................................................................................................... 166
68 -9.070[F] COG2019 Archaeal adenylate kinase  ali follow..  16  3...........................................SVITGVAGVGKTTVLDIVARESG---------------------------PVVNYGTLMFEVRRGLVENRDQIRKLSRETQVDLQKLAGEEIGKMENAIVD--THMSIKTPFGYLPGLPEWVLRSINASVFVIIEAD....................................................................................................................................................................................................... 113
69 -9.070[R] COG3911 Predicted ATPase  ali follow..  12  9...........................................FVLTGGPGSGKTTLIAALRRASVVAGRGIVRDQSSIGGTALPWSDRTLFAELM---------------------------LSWEMRSYQNAVEQKGPVFFDR-GVPETLGYLPVADHVSTAAKRFRYNPRVFIADEERKQTPDEAKCTYHALAEIYTELGYELVPL-TRLRFV................................................................................................................................................................... 176
70 -9.050[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  8  79...........................................FILLGLRGQAKSRILRAITELLDPEVPVID-MPDDPLNVEKLATPDVTVADLIGDVDPIKAARLGTSGLLPRANRGIF-----AVNELADLSPKVQVALFNIEGDVQI------------PIRLELDVMLVFSANPEDYTARGKIVTPLKDRIGSEIRTHYPTMDITAQEAVKEEGVVVP--PFIAELIEDIAFQAREDGRIDKLSGVSQRLPISLMELACANAERRSLVSGDAPVVRVTDVYAGLPAITKMELEYEGELKGADNVAKDLIRKAAGAAYARSYGSADTRELEKWFDQGNVFRFPQGGDASAALKATGEVPGLSDFAAQ........ 437
71 -9.030[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  10  6...........................................ILLTGTPGVGKTTLGKELASKS-----GLKYINVGDLAREEQLYDGYDEEYDCPILDEMREGGVIVDYHGCDFFPVLRTDTNVLYERLETRGYNEKKLTDNIQCEI--------FQVLYEEATASYKEEIVHQLPSNKPEELENNVDQILKWIEQWIK.................................................................................................................................................................................. 168
72 -9.030[F] COG1936 Predicted nucleotide kinase (related to CMP and AMP kinases)  ali follow..  13  1.........................................MLIAITGTPGVGKTTVAKLLAKKL-----NYEYVSLKDFALEKGCGRRVNDEVEVEIDELAYFIERELKGKNAVLVVVLRAHPKLIGERLRERGYDREKIGENVEAEL--------VDAVLIEAIEEHEN--VIEVDTT--KSPEDVVEEIVSLINSGIKKRVGIVDWSEVYD..................................................................................................................................................................... 169
73 -9.010[DZ] COG5019 Septin family protein  ali follow..  11  83............................NQWHRRCVRQGFNFNVLVLGESGSGKSTLVNTLLN-------------YPPTQKSLTGDFGVNPEPTVMINSSAVE--------------------------IVENGISLQLNVIDTPGFGDFIDNTDCWQPVLTDIEGRYDQACIFFIQPT-----GHAISAMELRVMLALHEKVNIIPIIAKADTLTDDEKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAIIASNVDNEEHSDFPKLREMLIRTHLEELKEQTNK-EAYRTERLLSSGISQDHSVFREVNPSAKLEEERALHEEKLMKMEAEMKTIFSQKVQEKEDRLKQSENELRTRHREMKAAL. 437
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Liu T, Rojas A, Ye Y, Godzik A. Homology modeling provides insights into the binding mode of the PAAD/DAPIN/pyrin domain, a fourth member of the CARD/DD/DED domain family. Protein Sci. 2003 Sep;12(9):1872-81.