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Query: [E] KOG1706 Argininosuccinate synthase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAKLast
1 -133.000[E] KOG1706 Argininosuccinate synthase  ali  100  1MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSREFVEEFIWPAIQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELSCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKNPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDILEIEFKKGVPVKVTNVKDGTTHQTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIAKSQERVEGKVQVSVLKGQVYILGRESPLSLYNEELVSMNVQGDYEPTDATGFININSLRLKEYHRLQSKVTAK 412
2 -112.000[E] COG0137 Argininosuccinate synthase  ali follow..  40  1MGRAKKVVLAYSGGVDTSVCIPYLMHEWGVVITLAADLGQGDELGPIQEKALRCGAVESLVIDGKEEFVKEYAFRSIQANALYENRYPLSTALARPLIAKMLVEAAEKYGADAVAHGCTGKGNDQVRFDISIMALNPNLKVLAPAREWKM-----SREETIAYGERYGVESPVKKSSPYSIDRNILGRSIEAGPLEDPMTEPTEEIYLMTKAIADTPDEPEYVDIGFEKGIPVSLNGVM-----LDPVTLVERLNEIAGNHGVGRLDMVENRVVGIKSREIYEAPALLVLIDAHRDLESLTQTADVTHYKNTVEEIYSQLIYRGLWYSPLKEALDAFIVKTQERVTGMVRVKFFKGNANVAGRKSDYSIYDAELATYGMEDQFDHKAAEGFIYIWGLPTKVWAQKMRG.... 400
3 -29.300[J] COG0482 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain  ali follow..  12  21.NRKKKVICGMSGGVDSSVSAFILQQQGYQVEGLFMKNWEEADLADAQAVCDKLG-IKLHKINFAAEYWDNVFEHFLQEYKAGRTPNPDILCNKEIKFKAFLDYAAEDLGADYIATGHYVRRGEKDGQCQLLRGLDNNKDQSDQVAQSLFPVGEIEKPIVRAIAEDLGLATAKKKD---STGICFIGERKFKDFLARYLPAQPGEIRTVEGKVVGRHDGLMYHTLGQRKGLGIGGVKGMGEDPF-----YVVEKDLVNNVLVVAQGH---------------DNSALLSSGLIASQLHWVDRQPIRQPVRCTVKTRYRQEDIPCEIQPINDETIRVVFDEPQIAVTPGQSAVFYQGEICLGG.................................................. 375
4 -27.700[J] KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase  ali follow..  9  3.EKPLRVAVLLSGGVDSSVALRLLHAAGHSCTAFYLKIWFQDDLKYAKHVCEQVD-VPLEVVHLTDEYWERVVSYIIEEYRCGRTPNPDVLC-NTRIKFGAFMDAISDMEYDYVGSGHYAKSQDMVKDQTYFLSHLSQ----TQLKRLLFPLGCVKKDEVRKLATQFDLPNKDRKD---SQGICFLGKIKFSDFVCRHIGEMEGIILEAESGDF----------LGNHRGFWFYTIGQRQGLRLPGGPWYVVEKDTKNNVVFVSRNY---------------YSIDKRRRIFRVGSLRWNSGKPSGKVRELRCKVRHGPGFYSCS--EGDGDVAVVHLDEDDQGLAAGQFAAFYEGTTCIGSGVILESWDDQCFPALQLAALEDKTKLGKPVKIMTMPTMSSVEADTGEASA 414
5 -23.400[J] COG2117 Predicted subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain  ali follow..  22  2...LGDVYHLFSGGKDSSLAAWILRKLGYEVRLVTITFGVLDNWKYAKETADILG-FEHEVVRLPRELLNMAVEMCIEDGKPGRAIQF-----------------LHEKALEYVASRSYVK................................................................................................................................................................................................................................................................................................... 101
6 -19.600[R] COG1365 Predicted ATPase (PP-loop superfamily)  ali follow..  16  52DKINVKIAVAYSGGSDSSATVKILRWAGFDVVPITARLPHISK-EKLREETLFVE-VPGYLEEMEKLIEKR--------------APICGRC--HSMVMRAVEEKVRELKIRILATG------DMLSIGSGSIYEKENLVILNLPAFLSL-----NKVDLLSILGWEDYEFK................................................................................................................................................................................................................................................ 194
7 -18.900[R] COG0603 Predicted PP-loop superfamily ATPase  ali follow..  19  1M---KRAVVVFSGGQDSTTCLVQALQQYDEVHCVTFDYGQRAEIDVARELALKLGARAHKVLDVVSSLTRDSIPVPDYEPEADGIPNTFVPG-RNILFLTLAAIYAYQVKAEAVITGVCETDFSKVLNHAVSLGMAKDIRFETPLMWI-------DKAETWALADYYGKL.................................................................................................................................................................................................................................................. 178
8 -15.900[R] COG1606 ATP-utilizing enzymes of the PP-loop superfamily  ali follow..  17  11IKSKKKLVVMFSGGVDSTLLAKLAREVGKNAVALTIDS-PRKEIEEAKNLANLIG-IRHEFIELNE---------LKSRHLIENPPDRCYLC--RKLRDNIVKNWARENGFDVIADGLNFSDLQDYRPGVKAST---EDGIWHPFIDFEV-----TKEEIREYSKKLGLPTWDKPAMA.......................................................................................................................................................................................................................................... 171
9 -11.500[R] KOG2840 Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily  ali follow..  12  47FRRGEKVAVAASGGKDSTVLAHVLKL-GLELVLLSIDEGRDDSLETVKQNRDDYQ-MPLKILSYEELYGWTMDRIVAQIGRSN------NCTFCGVFRRQALDRGAKLLGVDSIATGHNADDIAETVLMNVLRGGEDTIPRVKPLKYS-------YEKEIVMYAHYKKLVYFSTE............................................................................................................................................................................................................................................. 232
10 -11.000[R] KOG2316 Predicted ATPase (PP-loop superfamily)  ali follow..  12  2.....RVAALISGGKDSCYNMMQCIAAGHQIVALANLRPAENQVGSDELDSYMYQTVGHHAIDLYAEAMALPLYRRTIRGRSLDTRQVYTKCEGDEVLYELLKLVKEKEEVEGISVGAILSDYQRIRVENVCKRLN--LQPLAYL--------QRNQEDLLREMISSNIQAMIIKVAALGLDPDKHLGKTLDQMEPY....................................................................................................................................................................................................................... 186
11 -10.100[F] COG0519 GMP synthase, PP-ATPase domain/subunit  ali follow..  23  20..GSSKVLLGLSGGVDSSVVAALLHKAGDQLTCVFVDNGLHEGDQVMAMFAENMG-VKVIRANAEDKFLG...................................................................................................................................................................................................................................................................................................................................................... 90
12 -9.600[H] COG0301 Thiamine biosynthesis ATP pyrophosphatase  ali follow..  15  206LGTQEDVLSLISGGFDSGVSSYLHIKRGSKVHYCFFNLGGPAHEIGVKQTAYYLAKVRFIAIDFAP----------VVAEILEKIDDGQMGVVLKRMFMRTAGMVAEKFGIQALVTGALGQVSSQTLTNLRHIDNVTDTLILRPL---------WDKEDIIRLAREIGT................................................................................................................................................................................................................................................... 365
13 -9.040[S] KOG2594 Uncharacterized conserved protein  ali follow..  11  56GRKSKRAMLAISGGISSMAMLETANYMFDELLAVHFQWGTDSAVAKTIEESISYPKCPFKVIGEAELLNRTI-ADNEKFNPEVISSLASRQDLLYRIRDKLLVSYARKANCDTIVFGDSGTTIAARVLELVAEGRGFAIFLLRPLREV-------LSSDLKSYMNIKGLAFCDSLIEARPNTIH----GVTESYFSSLNDTFPSLVSTVVKMSSKLHVPST............................................................................................................................................................................................... 303
FFAS is supported by the NIH grant R01-GM087218-01
1 4 7 2 8 5   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Godzik A. Discovering new genes with advanced homology detection. Trends Biotechnol. 2002 Aug;20(8):315-6.