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Query: [MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAENGWKFLTCEPFEKPFDETDRFYENMPTFLDKIKEWPDYLIFFEERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKLLast
1 -162.000[MO] KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis  ali  100  1MRIWFWLAILVFRWWNALWVKTFFQPDEFYQSLEVAHHFIFRYGFLTWEWTSAIRSALHPLIFAALYRVLQVLKLDSSYFVFTNAPKLLQGTFAAILDYGTYKFALVRYGSKTANWTLACSLVSIMNAYVGVRTFSNSLETTLTSIGFYYFSYYLKYENSSPEQRKKAYSSLLGFISVAAFACFIRPTNILVWIFPLLFWNKNPQTPIKDLLSFSNVFNRFRFLYALGYGRLFGIFVLCVSLFLVNIIADRILYGRFVFPIISFFQFNVTSGLSSLYGLNAWHYYLSQALPLICGGFLPFVLLTMDLQTAGTILCVFFPYSLIGHKELRFVYPISPILLTLAGKFFSSFSSWKRAARFFFLIGLGHALVITFLCRFHQFGVMEVMPLIHSLAEKNQTGLILAPCHTTPWQSHIHSPFAENGWKFLTCEPFEKPFDETDRFYENMPTFLDKIKEWPDYLIFFEERFYSLYSYLDSRGLKYEEVQRYYNSLIPESRERAGALLVYKKL 506
2 -107.000[G] KOG4123 Putative alpha 1,2 mannosyltransferase  ali follow..  18  17..LSTYFCFAAVRLLLVFVPQGYVHPDEFFQSVEVMTGDHFRLHTRTWEFNNPVRSIVLPFALLRIPWSFYEFVALLGTYAYVVFPRLIYTLISFSNDYCLFRICRLYGLR--FEIRLLAMGSSWILLVFGTRTFSNSLEMAMCSWLLCLVSECMLRTNTVVYKKEHNLQHLMAMSTICVAGVFNRPTFLLFGAPMVFFWLLRGMGTRSITF-------------RDFNLRIALFCLCALPALVLFIFCDSLYYQNFVFTPWNFIKANLDSAQTASHGVHPCYVHLMVNMPMLFNVLALASLGAFAQLMSGAIFVPLFFLSLINHQEPRFLLPVTFPLILLHAPKLITGFSAKYPPYLLKIWYVSNVALTLFFGFIHQAGVYPLAADISHVIATKPTHVHLITSHIYSLPLHLINIPSSRVLHFYRRPRDFYMYEYGGLPLDSLLQKVKLRRRYKLYLAIPASLSADLHEALVSSYLNFELLKVFYP-HLSTEA............ 617
3 -92.800[MU] KOG2515 Mannosyltransferase  ali follow..  15  15..VWTFSILAVLRLTSASF-RVIDDCDEVYNYWEPLHYLLYGYGLQTWEYSPAIRSWFYIALHAVPGFLARGLGL--SRLHVFYFIRGVLACFSAFCETNLILAVARNFNRAVALHLTSVLFVNSGMWSASTSFLPSSFAMNMVTLALSAQLSPPSTKRTVK-----------VVSFITIGAVIGWPFSAALSIPFILLELVDLKGR-----------------FRHLFCRWFKAIFVALLITGICITVDSLFYHRIQFVAWNIVKYNVLAKDGRIYGTEPWWYYFANLSLQHNIVLWFAMACGPLSSVISPFYIWLFIFIIQPHKEERFMYPIYPVLCLAAAIGLDMSLKLMIQIVLCVYAIIGCLSIARILAIQNYNAPMIIYPAISFLETDNNNVCVGKEWYRYPSTFFLPDNS---RLKFVKSEFPGEFVESNSTWWNREGYYQEFNNEEPTRYTSLESCDFLIDLEFDIDTKQTPFMGRAF--AVPFIEPKWGRYEILVK. 559
4 -77.500[MU] KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family)  ali follow..  12  5.....VLDTVLLTVISFHLIQAPFTKVEESFNIQAIHDILTYSVFDISQYDHSLIQTSRPTSIDVQLVVRGIVGLTNG-LSFIYLKNCLQDMFDEITEKKKEENEDKDIYDSAGTWFLLFLIGSFHLMFYSTRTLPNFVMTLPLTNVALGWVL--------------LGRYNAAIFLSALVAIVFRLEVSALSAGIALFSVIFKKIS--------------------LFDAIKFGIFGLGLGSAISITVDSYFWQEWCLPEVDGFLFNVVAGYASKWGVEPVTAYFTHYLRMMFMPPTVLLLNYFGKIVSLASLFHIIVLSFQPHKEWRFIIYAVPSIMLLGATGAAHLWENMKVKKITNVLCLAILPLSIMTSFFISMAFLYISRMNYPGGEAL-TSFNDMIVEKNITNATVHISIPPCMTGELNYGVYGINYDKTENTTLLQEMWPS------DFLITHEELVNTTKMFLLKQIIFDKTPTVFLKELTANSIVKSDVFFTYKRI 544
5 -18.800[M] COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family  ali follow..  9  1MKSVRYLIGLFAFIACYYLTRLLWQPDE--RYAEISREMLASGDWIVPHLLGLRYFEKPIAGYWINSIGQWLFGANN------FGVRAGVIFATLLTAALVTWFTLRLWDKRLALLATVIYLSLFIVYAIGTYAVLDPFIAFWLVAGMCSFWLAMQAQTW-----KGKSAGFLLLGITCGMGVMTKGFLALAVPVLSVLPWVATQKRWKDLFIYG------------------------WLAVISCVLTVLPWGLAIAQREPNFWHYFFWVEHIQRFALAPFWYYVPV-IIAGSLPWLGLLPGALYTGLLSWTIMPLLFFSVAKGKLPTYILSCFASLAMLMAHYALLAAKNNPLALRINGWINIAFGVTGIIATF.................................................................................................................................. 361
6 -18.100[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  7  19....VTAAALLARLWA--LGWRVAHQDEARVADWTLQYMDLG----AWQYRPIIHG---PFLPHVNGVVFDVFGATD------FTMRLVVAVVGGLLPLTAWLYRTRL-SDVEVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVRFLDTHRA---------RYLYASAVPFALAFTTKENSLLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRRAAARIRHRAWRAKAALAGSALTAAVIVVSFAATIGTYHEFADLWASTSTVAHSYVAFLSHDLACGTVVSVAAVVGYLANPLVSFAFYWGVFSVLGYPAVDIAAAWTAVNALVPLAIPAAVGVGAVVRYGRRGAAAAVRLAVTVLVVSAAGMGAVAAETTYAHPMQPTIDDIQRAATATSGLDVLYYGDSNDTADDGLEFSDAGDGTFNVTTGPPSGWHDPFPWYLSQVG-PPVVISVVSEEDDFAALLA----AADNSQYERHTYPRYLTDGHNTLVIYVD. 562
7 -18.100[S] COG4713 Predicted membrane protein  ali follow..  11  8VEYIFMAFALFFGVLFAVINAPFQDPDEFYRAYQISTGQMFNKNKVAFNDFRSATIYSDIVYIPQSIGINLAKIFRASALYMMYFGRIANLICWTIIVFFSVKLIPF------KKNLMAFLALTPMNLYQAASLSADAMTNSMAFLSIALVLRYAFGEEEA----KLTKRQIVTMIIAFTLLAFSKRIYFVMCILFFIIPIKKFNSKKDYIGTFVIMLGACLMSLVTVSVISKILAISYTPGQMEFVLSHPITYIHILLRTFHFKMSFYAISFIGVFG--PLNLYLFYGVALVLIALFEHTLIEKNKDRIIMFIVFIINVGLI---QGRYFIPIIPLLGCFIGVKANKSRNVYSKVVLAISTFTILTYSVLQL..................................................................................................................................... 446
8 -14.900[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  8  193......................................................................................RIPGIIEHALIVIIVTLVAYKITKSYASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLA----------------LDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEKDLKEYLISGLV--------------------LPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWMWFVAVTDPILMISMIVFVFAVPYVMFWSIIAFFALQYILGGKTQFIFATPLIPPGAVALGVISYEIIKWEYFERSLRIYLYLRSIAKPLKKVIKR................................................................................................................................ 477
9 -13.300[S] COG5305 Predicted membrane protein  ali follow..  9  1....MFSLGNSFLPVPL---DQAIAPDILLQPLQPNPASGIGD------IHNLITEDNHPPLYFVLVHLWMKLFPNQGELVSLLAARSFPALLGAVSIPLTYILGRLAFSSLVGQLAAGMMAVSPYAVYLGQEVRHYTLAMIWVIASLSCLVIATRHIQNR---TLLPFWLIILWVGINALGIATHYFFTLTLCAEALVLIFLAWQQSTQAKTLVFFSPLWWRIYAVAAGTAVAGLFAAWVTMIMLLPIESSQLAVVIASGLVMLIFAIWATP-----------ILVRGFKFQLQQPQTSLATQVFIGVVLGAIALFFILTYIFGVDIRYNFVYFPAVIILVGASLAVYWQTSKKA----------VMIIWLMGFVSAVTVICNLGYQKYYRPDLLVQIIQQNSQVPVLIATTHKTLVQ....................................................................................... 423
10 -13.000[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  9  27....AWLAGFSSRLFAVIRFESIIHEFDPWFNYRATAYMVQNGWYNFLNWFDERAWY-YPGLMITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAGAGLFAASFIAIV-----YISRSVNEGIAIFALQFTYFLWVRSVKTGSVF-----SAAAALSYFYMVSAWGGYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILGLLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRIIASVSEHQPTTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFAGVMVRLMLTLTPVVCMLAGVAFSGL............................................................................................................................................................. 426
11 -12.900[R] COG1287 Uncharacterized membrane protein, required for N-linked glycosylation  ali follow..  12  32....IAVASVSSRLFSVIRYESIIHEFDPWFNFRASKILVEQ-ERSWYPLGRVAGGTLYPGLMVTSGIIFKVLHLLRINVNIRDVCVLLAPAFSGITAIATYYLARELKSDACGLLAAAFMGIA-----YTSRSVNEAIAITLLMSTFALWIKAVKSGSSF-----GACTGLLYFYMVTAWGGYVFITNMIPLHVFVLLLMGRYTSKLYIAYTTYYVIGTLASMQVPFVGFQPVSTSEHMSALGVFGLLQLFAFYNYVKGLVSSKQFQIIASVSEHQPPTWSSLFFDLQFLIWLLPVGVYLCFKELRNEHVFIIIYSVLGTYFCGVMVRLVLTLTPCVCIAAAVAISTLLD........................................................................................................................................................... 433
12 -12.300[OKIT] KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator  ali follow..  9  29....SCIHVLLTTIVYHYVPEPYM--DEIFHITQTRS---YCSGNYSWNPLITTPPALY-VISMPLCGGNERYANSILLFFAIPAFCRFRRMFVRVRIPTLKIYLKNTDLQQDVWLTASIVGMLPILISSSILFYTDLLSLTSVIWGFSI-------------------GNPIASAFLFLISILTRQTNIIWAAIYAFSVIASRIDKSRVAFCAAHTWTQIIPNLLSHLRHLTDMKSLVLQAVVAVLVYYYSYDHPYLLADNRHFTFYIWRRFLA----NPTMRTTLAPL-YVFSLRFMTTSTPSVHIFHKILFIIASLLVLVPAHEMRYIIPYV--LWRLSTVNNSRKSLLFLEIISQAVIFAANEFVQKLQQKNEKEIKISRIQ........................................................................................................................ 438
13 -11.800[S] COG3463 Predicted membrane protein  ali follow..  8  7.KKLLVIIFIAYTFIIFKTC---------YENFSYKSLDLGIFSQSLYSTLNG--KFMYNTVEAQLYSAPNHFAVHFQPILLLLLP-LIQAIFLALSATLALLIACEELNHREAILVASLYIFNSSLLGIALFEFPVSLAVPLFFIAYMLL----------------KRGKMKLFYLTSVLILLTKEDSFLGVVSLSLWKILMDGLNPESFRKNRGLILLSIASMM-------------------------------YGIIVIKVVIPHLGMGYIYESLYSEFELTRRKLLYFIVFNASFGFLTFLSSKGLVSVALPWLESMLSSRDFHYPYMLLPLSYLVAIEGFKKSKKVAVSLIVAGILTSMATIPITFKPPKAENPLIHFAVLKPIPGKDASWEAITIVKTLEGPIYTQPEFYPH--------------------LSTRIDVYVYPKGIKPRVILVNLNTWNGKRAIKRIKLEEYKTVFK------------KDGVVIFIR. 446
14 -11.400[S] COG5542 Predicted integral membrane protein  ali follow..  10  33..GICVCTFLLSTILYLGITAMLYLRQNRSRLAESNIFRTLFISWIRWDSLFEQEWAFSSLWPKIISFLAFRSK---DVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQKMTAYTVIFYCFSPSGIYMSVGYTESLFAAFSFLGLLLF----------------IKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPAIGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKLFCP--VAWCNKSLPLIYPAVQEKYWNVGFLRYWTLNNIPNFLFALLSIIPILFALFYSRSIKSHLVLSALYLYIGCFHMHTQVRMSSALPLLYWSMAHATLYAKSRNLKAHCILFVWIVYTVIQAGLYGSF.................................................................................................................................. 422
15 -11.300[S] COG5617 Predicted integral membrane protein  ali follow..  8  1MKRKLYYLTLATISVIEYIPPPALQINGNGHLFKVHK--LMTSGWKPWDWYAGYPFLFYPPLSYLTAGVLGKVLGS-----DTKGYAATLMLTSFLGALALHHYLKSTGREPCISPLIFLLFPWHLTVSYIEGNFPRANAIHLAPLFLLSLYWLREKRE----------RYLIASALGISIVALTHYSILPLLIITGILILWDDLRTMTALGNG-------------------------IKVLGAVIGLTSFWY---FLFDKKWVEFWNISENKALFKSF---FGILLILLLLIFAIFAIKNLVDRKKVILAGLYLYLSLGFYS--PYRWFDLEALIIPLLIGESLKRVQRKSMVALVIIPFTVLAFMNVPKI..................................................................................................................................... 359
16 -9.480[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  11  15..TILIKYAIFSRLLVLFLTWRSLLQPENSVVWDSVYFLRITECGYEYEQTYAF---LLPFFISLLSRTVFLVPLIGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILDTEASFRASIIFCFNPASIFYSS-IYSESLYALFSIGGVYHL----------------LSGTSNVGVLWFALSGCARSNGILNAGYICFQTMHRAYEALYQKRRAYLAMQ-----------VFIAGFLRCICICLPFVAFQAYGYRPWCKGRIPLLYNFIQKILVSDRGVGFLKYFQFKQLPNFLLASPILSLAADVFPFIVHLSFMVTTAFFIMHVQVR-FLSASPPLYWFASSLIGSPKHSKWGYLIWSYCAAYILLGTLLFSNF.................................................................................................................................. 488
17 -9.430[S] COG5650 Predicted integral membrane protein  ali follow..  6  49...RVLITTSLVFLAMGFLTKAWSGSRQYYNDIVPLYG--IDAPGFPYAFSWQEGYMEYPVLGGIFQWICGIITVDVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRVWDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAV----------------KRGNPLVAGVLIGAGTAFK--WPLYLLGAYLVLAVKNKN------------------LKPFITMAAAAAVTWLVVNVPVMIAYPKAW-------NEFLRLNREREWTTIYQVLLNVLSFGLFGASCVAILILGLKVQRTPRVAELAFLIVAAFLLFNK-SPQYSLWLVPLAVLAF.................................................................................................................................................................... 392
18 -9.070[S] COG4485 Predicted membrane protein  ali follow..  9  11...YFISFIIPVVIMSGVYLSQSIYWDQYVIFDVALRNILHGNSNLFYTFTSGL-ALSSYYLGSFLAPLVYFFDLTNMPDAIYLTTLLKFGLIGLSTFFSLNKLFQSIPQILKLALSTSYALMSFTVSQLEIKTWLDVFILILIITGLHLLI-----------TEKKLLLYFTSLSILFIQNYYFGYMTVLFLIFWYLCQISWDFKT------------RKSSVLDFIVISFLAGMASLIMTLPTLFDLEVTKFQTESSWYLDLFAKQFIGSFDTTKYGAIPMIFVGLFPFILTILFFTLKSIKFHVKLIYVIFFAFLIASFY-Q--HRYAWIFSTLLIYTAAEVLKRLKELKVWNFLVSLFLVVAGFLATIY..................................................................................................................................... 396
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Pio F, Chu Z, Reed JC, Godzik A. PAAD - a new protein domain associated with apoptosis, cancer and autoimmune diseases. Trends Biochem Sci. 2001 Feb;26(2):85-7.