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Query: [TU] KOG1954 Endocytosis/signaling protein EHD1, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MYNFFRTVPRANRNEITFYPDYEEEGQKKKKTRSMFSWLGGDSSKKKNKEVLETVSEGLRKIYKQKLLPLEEFHKFHDFHSPALDDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVDAKKQFRALSGFGNAFLNRFQCSTLPNQVLESVTIVDTPGILSGEKQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGNEDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYLGSFWDHPLHYDLNRRLFQDEQHDLFQDLQALPRNAALRKLNDLIKRARLAKVHAYIIAELRKQMPSMIGKDKKKKDLIQNLDKIYEQLQREHNISPGDFPDVNKMREKLQTQDFSKFNPLKPKLLEVVDGMLATDIARLMAQIPKEEAAAPAGSNGSADPTVRGGAFSQTTEAETPFGFGRGEGFDKGADEAEWVVSRERTTADSTFESLGPVNGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGHEIPSELPKHLIPPSKRGEQDPVYPSLNDNDELast
1 -159.000[TU] KOG1954 Endocytosis/signaling protein EHD1  ali  100  1MYNFFRTVPRANRNEITFYPDYEEEGQKKKKTRSMFSWLGGDSSKKKNKEVLETVSEGLRKIYKQKLLPLEEFHKFHDFHSPALDDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVDAKKQFRALSGFGNAFLNRFQCSTLPNQVLESVTIVDTPGILSGEKQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGNEDKIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYLGSFWDHPLHYDLNRRLFQDEQHDLFQDLQALPRNAALRKLNDLIKRARLAKVHAYIIAELRKQMPSMIGKDKKKKDLIQNLDKIYEQLQREHNISPGDFPDVNKMREKLQTQDFSKFNPLKPKLLEVVDGMLATDIARLMAQIPKEEAAAPAGSNGSADPTVRGGAFSQTTEAETPFGFGRGEGFDKGADEAEWVVSRERTTADSTFESLGPVNGYLSGRAAKEHMVKSKLPNSVLGKVWKLADIDKDGQLDADEFALANYLINLKLEGHEIPSELPKHLIPPSKRGEQDPVYPSLNDNDE 589
2 -37.300[U] KOG1955 Ral-GTPase effector RALBP1  ali follow..  25  185......................................................................................................................................................................................................................................................................................................................................................................................................................................................PPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVG 336
3 -24.700[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  14  2........AEPVSPLKHFVLAKKGITAIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVYKDKLSIIGEVLSRRHMK--------------VAFFGRTSSGKSSVINAMLWDKV--LPSGIGHITNCFLSVEGTDGDKAY------SDEKKSVKTVNQLAHALHMRVFWPKAKCALLRDLVLVDSPGTDVTTEL--------DSWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNEWLSPNIFILNNRWDASASEPMERCLHFLVEELKVANALEAQNRIFFVS........................................................................................................................................................................................................................................................................................................... 284
4 -18.700[R] COG3596 Predicted GTPase  ali follow..  19  4..............................................KNFEVLQPLQNSLSGLPLWVSERILQQI-----------NQLTHYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTRDPLRFRLQIGE-----------------------------------------HFMTIVDLPGV----GESGVRDTEYAALYREQLPRLDLILWLIKADDRALATD-EHFYRQVEAYRHKMLFVISQSDKAEPTS....................................................................................................................................................................................................................................................................................................................................... 164
5 -18.000[R] KOG2486 Predicted GTPase  ali follow..  13  42..FSFASKSNLATVEPIPLSVSDSTDLDDAPVEIALDKLFIPPETDISGEDSASLTTRILKGSNIVLSKYARDAQVVQASSVKTEDCPADGLPEFALVGRSNVGKSSLLNSLVRRKRLALTSKKPGKTQCINHFRIN-------------------------------------------DKWYLVDLPGYGYASAPHELKQ-DWNKFTKDYFSTLVSVFLLVDA-SIPVKPIDLEYASWLGQNQVPMTLIFTKCDKRKKKKNGG.................................................................................................................................................................................................................................................................................................................................... 266
6 -16.800[R] COG0699 Predicted GTPases (dynamin-related)  ali follow..  10  195..DTTVGIGAALAASILSVDSVDGEDTLTADEKRKLAQESKEDRMMLFTKKMIEIRNILQDIQ-----------------------NSAVTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNM--TRRPIELTLVHSADTAIPYGEFSGVQLGKITDFSKISQGVDDNPIRLTIYASHIPNLSLIDLPGYIQIHSEDQPAD--ISKLCEKYIREPNIILAVCAADVDLANSAALRASRRVDPLGLRTIGVVTKMDLVPPSKAISILHNNNYPLH-VISRIVPTGRFSAGQNLTDLVSTQENSYFSTHQQSLRKCLINVLEYTMSKNLQHTADSIRTELEECN...................................................................................................................................................................................................................................................... 545
7 -15.700[R] COG1084 Predicted GTPase  ali follow..  14  106.................................SDYMARIKRSKPSDASHLRREAFGRISSVIKRIEGDLDFLDFAKNKLRN--MPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAE------------------------------PEVAD--YPFTTKGIQIGHLERK-----------KRIQVIDTPGLLDRPVEDMNN---ELQAMVALENIADVIMFIFDASE-TLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKYLE.................................................................................................................................................................................................................................................................................................................................... 294
8 -15.500[R] COG1159 GTPase  ali follow..  22  10.............................................................................................FIAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGPY-----------------------------------------QAIYVDTPGLHMEEKRAINR---MNKAASSSIGDVELVIFVVEGTRWTPDDE--MVLNKLRDGKAPVILAVNKVDNVQEKVDL..................................................................................................................................................................................................................................................................................................................................... 135
9 -15.300[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  17  3..............................STLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVY-------SEVAAYEFTTLT-------------------TVPGVIRYKGA----------------KIQLLDLPGIIEGAKDGKGRGRQVIAVAR----TCNLILIVLDVLKP---GHKKIIENELEGFGIRLNIGFKKKDKGGINLTATC................................................................................................................................................................................................................................................................................................................................... 195
10 -15.300[R] COG0218 Predicted GTPase  ali follow..  24  26............................................................................................PEIALAGRSNVGKSSFINTMLNRK---ARTSGKP------------------GKT---------QLLNFF---------------NIDDKMRFVDVPGYGYARVSKKEREKWGCMIEEYLTTRENLVVSLVDL-RHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKKKLN.......................................................................................................................................................................................................................................................................................................................... 166
11 -15.100[UR] KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins  ali follow..  12  1..............................................MSVDDLPPSSASAVTPLGSSVIPIVNKLQ------AQLGSQSTIALPQVAVVGSQSSGKSSVLEALVGRDFLPRGNDITKPSSDGGSDEEWGEFLHHDPVRRIYDFSEIRREIEA-NKGVSDIPIGLKIFSPNVLDISLVDLPGITKVPVGDQPSD--IRTMILTYIKEPSCLILAVSPANTDLNSDALQIAGNADPDGHRTIGVITKLDIMDRRNHLL---RLGYVGVVNRSQEDILMNRSIK------ALVAEEKFFRSRPPQLAKKLNQVLVQHIKALLPSLKSRINNALFATA...................................................................................................................................................................................................................................................... 329
12 -14.900[R] COG1163 Predicted GTPase  ali follow..  16  3..............................TTVEKIKAIEDEMARTQKNKATSFHLGQLKKLAKLRRELLTSASSGSGGGAGIGFDVARTGVASVGFVGFPSVGKSTLLSKLTGTE-------SEAAEYEFTTLV-------------------TVPGVIRYKGA----------------KIQMLDLPGIIDGAKDGRGRGKQVIAVAR----TCNLLFIILDVNKP---HHKQIIEKELEGVGIRLDILIKKKEK............................................................................................................................................................................................................................................................................................................................................ 187
13 -14.800[R] COG2229 Predicted GTPase  ali follow..  19  6..............................................................................................IIFTGPVGVGKTTAIAAISDEALVQTDASAS-----------DMTLDRKRNTTVAMD----------YGAISLDE------------KVHLYGTPG--------QER---FNFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGLLEKAPVVVTKMDIRSQPGIDVYHKYL............................................................................................................................................................................................................................................................................................................................... 141
14 -14.600[T] KOG3886 GTP-binding protein  ali follow..  16  5........................................................DSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGN-----------------VLNLWDCGG------QDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLEC-SCFRTSIWDETLY-----KAWSSIVYQLIPNVQQLEM............................................................................................................................................................................................................................................................................ 250
15 -14.200[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  21  335.......................................................................................ELKSIADLGLIGLPNAGKSTILNKISNAK-------PKIGHWQFTTLS---------GTVSLGFGQDVF---------------------------TVADIPGIIQGASLDKGMGLEFLR-----IERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKNILIVCNKVDIDAEKSESF---AKYLQVEKFSKSQEWDCVPISA........................................................................................................................................................................................................................................................................................................... 494
16 -14.000[R] KOG1673 Ras GTPases  ali follow..  15  104..............................................................................................ISLLGDCQTGKTTFVVKYVGDENQ--------------------------------------SFLEMTGLNLMDK--TFYVQGVTIS-FSIWDVGG-------DEKR---SKDHIPIACKDAVAILFMFDLTSRSTLNSVFGWYSQARKWNKTAIPILTKFDDFQARAYAKVMNASLFFSS-ATHNINVNKIFK............................................................................................................................................................................................................................................................................................................. 260
17 -13.900[E] COG4917 Ethanolamine utilization protein  ali follow..  22  2............................................................................................KRIAFVGSVGAGKTTLFNALQG-----------------------------------------------------NYTLARKTQAVEFNDKGDIDTPGEYFNHPR-------WYHALITTLQDVDMLIYVHGAND---PESRLPAGLLDIGVSKRQIAVISKTDMPDAD........................................................................................................................................................................................................................................................................................................................................ 107
18 -13.900[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  15  1.............................MGIIERIKEIEAEMARTQKNKATEYHLGQLKAKIAKLRTQLLEPPKGASGGGEGF-EVTKYGHGRVALIGFPSVGKSTLLTMLTGTH-------SEAASYEFTTLT-------------------CIPGVIHYNDT----------------KIQLLDLPGIIEGASEGKGRGRQVIAVAK----SSDLVLMVLDASKSE--GHRQILTKELEAVGLRLNIYFKKKKT............................................................................................................................................................................................................................................................................................................................................ 184
19 -13.800[J] KOG0468 U5 snRNP-specific protein  ali follow..  13  13IGPDLDSDEEDEQSIYGQPDVQDDPEDAMDEDEVEPQEDEDKEVTAVVLHEDKRYYPSAVEVYGPDVETIVQEEDAQPLDKPLIEPADLMDTP-VALVGHLHHGKTTFVDCLIRQTHPQFETM-EERQLRYTDTLFTEQERGCSIKATPVTLVLQDVKQKSY--------------------LNIFDTPGHV-----------NFSDEATAAMRMSDGVVLFIDAAE-GVMLNTERLLKHAVQERQAITVCINKIDRLPPQDAYFKLKHIVEEVNGLLST..................................................................................................................................................................................................................................................................................................................... 293
20 -13.700[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  14  110...............................SKDYVKLLKYGDSLYRCKCLKVAALGRMCTVLKRITPSLAYLEQIRQHMAR---PSIDPNTRTVLICGYPNVGKSSFMNKV---------TRADVDVQPY-----------------------AFTTKSFVGHTDYKY-----------LRYQVIDTPGILDRPFE--DRNIIEMCSITALAHLRAAVLFFLDISG-SCGYTIAQQAALFHSIKSLFMIVCNKTDLMPMENISEEDRKLI.............................................................................................................................................................................................................................................................................................................................. 307
21 -13.500[T] KOG4252 GTP-binding protein  ali follow..  17  1...................................................................................MLEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTK-------------------------------------DYKKTIGVDFLER--QIQVNDEDVR-LMLWDTAG--------QEE---FDAITKAYYRGAQACVLVFSTTDRGSFEAVSSWREKVVAEVGDIPTVLNKIDLLDDSCIKNEEAEAL.............................................................................................................................................................................................................................................................................................................................. 139
22 -13.300[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  18  53.........................................................................................TKSNTVLLSGLSGSGKTVLFYQLRGSSHQGAVTSMEPNEGTFVLHNENNTKKGKV------------------------------------KPVHLIDVPG-------------RLISKLEEYLPRAAAVVFVVDALEFAASEYLYDILTNASVIKNKTPVLLNKTDKVTAHTKEFIRKQMEKEIDKLRVSR.................................................................................................................................................................................................................................................................................................................... 205
23 -12.700[T] COG1217 Predicted membrane GTPase involved in stress response  ali follow..  23  8..............................................................................................IAIIAHVDHGKTTLVDKLLKLS--------------------GTLDRKEAESERVMDSN-------------QEKERGITILAKNTANINIVDTPGHA-----------DFGGEVERVMSMVDSVLLVVDAQD-GPMPQTRFVTQKAFKAGLRPIVVVNKIDRPGAR........................................................................................................................................................................................................................................................................................................................................ 136
24 -12.600[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  21  1...................................................................................MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSTTVGIDFREKRVVYRASGPDGATGRGQRI---------------------------------HLQLWDTAG--------QER---FRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHCENPDIVLNKSDLEDQRVVKEEEAIAL.............................................................................................................................................................................................................................................................................................................................. 151
25 -12.600[R] KOG0395 Ras-related GTPase  ali follow..  20  22..............................................................................................MVVLGASRVGKSSIVSRFLNGRFEDQY---TPTIEDFH-----RKVYNIRGDMY---------------------------------QLDILDTSG-----------NHPFPAMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKAELPMVINKNDHGELCRQVP.................................................................................................................................................................................................................................................................................................................................... 152
26 -12.500[J] KOG0469 Elongation factor 2  ali follow..  14  22..............................................................................................MSVIAHVDHGKSTLTDSLV---KAGIIAGSKAGETRFTDTRKDEQERCITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYINLIDSPGHV-----------DFSSEVTAALRVTDGALVVVDCVS-GVCVQTETVLRQAIAERIKPVLFMNKMDRAGAEELFQTFQRIVENINVIIAT..................................................................................................................................................................................................................................................................................................................... 203
27 -12.500[R] KOG1533 Predicted GTPase  ali follow..  16  36..............................................................................................VLVIGAPGAGKSTFCDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLPNGALKYCIETLGANCNLLQKIEANHKKYLIIDCPGQLE---------YKSEGELWKVIRFLECALHLADSLYCSDPSKFISVALSTLATMVTMEMCLSKADLFSEDGTYDL................................................................................................................................................................................................................................................................................................................................... 215
28 -12.400[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  18  393..NSVRLASATEQQPLLDSGGGVSATAVARPPVAPAPVAPGPGSEGASATLCKNAGRALIRMISSSKAPEEE------------DEFDIMGK--VIMLGDSGVGKTSLLIRFRDGRYVPSYF------------------------------------LSTVGIDF--RNKVVVVDGTRVK-LQIWDTAG--------QER---FRSVTHAYYRDAHALLLLYDVTNKTTYDNIRAWLGEIREYQEDVVIVLNKADC-DGERLGREHNVPFMETS.......................................................................................................................................................................................................................................................................................................................... 613
29 -12.300[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  21  1...................................................................................MASVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTTYQ-------------------------------------ATIGIDFLSK--TMYLEDRTVR-LQLWDTAG--------QER---FRSLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRNERAGIVLVGNKTDLVEKRQVSIEEGD................................................................................................................................................................................................................................................................................................................................ 138
30 -12.200[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  18  3....................................................................................GTRDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSE-------------------------------------NYITTIGVDF--KIRTMDINGQRVK-LQIWDTAG--------QER---FRTITSTYYRGTHGVVVVYDVTNGESFGNVKRWLQEIENNCDSVQKVLNKCEENERRVVLESDARNY.............................................................................................................................................................................................................................................................................................................................. 140
31 -12.100[R] KOG0410 Predicted GTP binding protein  ali follow..  16  220ILDIFNQRAATHEAALQVAAQMEYQLPRLTRMWTHLERQSGGQVKGMGEKQIEVDKRILRTQIGVLKKELESVRKHRKQYRSRRVAIPV---PVVSLVGYTNAGKSTLLNQLTGAN--------------------------------VLAENRLFATLDP---------TTRRVQMQNGKEFLLTDTVGFIQKLPTTLVAA--FRATLE--IAESSLLVHVVDISHPLAEQQIEKVMSELDVSSIPKLVVWNKVDRVDDPQKVKL................................................................................................................................................................................................................................................................................................................................... 442
32 -12.100[K] KOG1534 Putative transcription factor FET5  ali follow..  14  6..............................................................................................AFVCGVASSGKSTFCSYMKSVGRSCHLVNLDPAAENFEWEPTVDIRDLISIDDVMEELDYPNGGLIYCFEFLMENLDLNEEIGDYDEDYLIFDMPGQIE---------YTHVPILPALIRHLQCAVYLLESQFLVDRTKFFAGVLSAMSAMVMMEVLLSKMDLLKDNNNIT.................................................................................................................................................................................................................................................................................................................................... 185
33 -12.100[R] COG1160 Predicted GTPases  ali follow..  23  2..........................................................................................ATPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRK------------------------YGHAHIAGYDF-----------------IVIDTGGIDGTEEGVEEK---MAEQSLLAIDEADIVLFLVDA-RAGLTAADIGIANYLRQRQNKTVVVANKTDGIDADSHCAEFYQL............................................................................................................................................................................................................................................................................................................................... 137
34 -11.800[H] KOG2743 Cobalamin synthesis protein  ali follow..  19  43............................................................................................PVTIITGYLGAGKTTLLNYILT----------EQHSKRVAVILNESGEGSALEKSLASQGGELYEEWLELRNGCL----CCSVKDNGLRAIELLETTGLAD------------GAVASMFW-YLDGIITIVDSKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTI............................................................................................................................................................................................................................................................................................................................... 220
35 -11.700[M] COG0481 Membrane GTPase LepA  ali follow..  16  7..............................................................................................FSIIAHIDHGKSTLSDRLIQT------CGGLSDREMEAQVLDSMDLERERGITIKAQSTLNYKAKD--GETYQ---------------LNFIDTPG------------VDFSYEVSRSLAACEGALLVVDAGQ-GVEAQTLANCYTAIEMNLEVVPILNKIDLPAAD........................................................................................................................................................................................................................................................................................................................................ 139
36 -11.600[J] KOG0462 Elongation factor-type GTP-binding protein  ali follow..  17  45..............................................................................................FGIVAHVDHGKSTLADRLL----------------EMCGAVPPGQKQMLDKLQVERER----------GITVKAQTAALRHRG----LLNLIDTPG------------VDFSAEVSRSLAVCDGILLLVAANQ-GVQAQTIANFWLAFEKNIQIIPVINKIDLPGATQLKNLFEFN............................................................................................................................................................................................................................................................................................................................... 185
37 -11.600[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  19  30..............................................................................................FLTCGSVDDGKSTLIGRLLSLHNDSKRHGTQGEKLDLALLVDGLQAEREQGITI--DVAYRYFSTEK-------------------RKFIIADTPG-------------QYTRNMATGASTCELAILLIDARKLDQTRRHSFISTLLG---KHLVVAINKMDLVDYSEFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESMPWYSGP-TLLEVLETVE............................................................................................................................................................................................................................................................................. 236
38 -11.500[J] KOG1191 Mitochondrial GTPase  ali follow..  17  315...........................................EDEMPPLDIESVINKITSM-SQDVESALDTANYDKLLQSGLQ---------IAIVGRPNVGKSSLLNAWSKSERAIVTEVAGTTRD-------------------VVEANVTVRGVP----------------------ITLLDTAGIRETNDIVEKIGVERSETA---AKVADVIIMAVSAVE-GWTEEDTELLRKIQSDKQPMILVMNKIDCAPPGSCDQLEDQR............................................................................................................................................................................................................................................................................................................................... 502
39 -11.500[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  21  15..............................................................................................LVLVGDGGTGKTTFVKRHLTGEFEK-------------------------------------KYIATIGVEVHPL--SFYTNFGEIK-FDVWDTAG--------QEK---FGGLRDGYYINAQCAIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLNKVDV-KTITFHRKKNLQYYDIS.......................................................................................................................................................................................................................................................................................................................... 152
40 -11.500[R] COG0536 Predicted GTPase  ali follow..  18  127...........................................................NAALASKARKAPGFALIGEPGEAHDLILELKSMADVGLVGFPSAGKSSLISVM---------SAAKPKIGDY-----------------------PFTTLQNLGVVNVGH-----------ETFTMADVPGLIPGASEGKGLGLDFLR-----IERTSVLVHVVDTAT-DPISDIEALEAELAAYQSALDVVLNKADVPEAEELAEFLKEDI.............................................................................................................................................................................................................................................................................................................................. 310
41 -11.400[D] COG3640 CO dehydrogenase maturation factor  ali follow..  13  5..........................................................................................GMPKLIISGRGGSGKSTLVTLIVDSDESNIGLGIEPAEKTLMDYLGGKPRESLSQEFVCWVGSLGLMQIGKIDHAMEGCAPMGAVTRDFLNHVRLVDTEGV--------------EHFGRGIVEGADAVVMVVDPSSDAVL-LAEKAAKLTHEADKRFGVILNKIDEETEPILTELLTSE--GNEIKGVLPYSPAITKMNLKGESLGAYAVKNEVDEIIRELMK................................................................................................................................................................................................................................................................................... 262
42 -11.400[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  18  23..............................................................................................LVLLGESAVGKSSLVLRFVKGQFHEFQE-------------------------------------STIGAAFLTQ--TVCLDDTTVK-FEIWDTAG--------QER---YHSLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQRQASPIALSGNKADLANKRAVDFQEAQ................................................................................................................................................................................................................................................................................................................................ 149
43 -11.300[DZ] COG5019 Septin family protein  ali follow..  13  30...STDNVTQINVEAAISENKNEEKPIQDNSEQEFNPHVSIIQRQLNGYVGFASLPNQWHR------RCVRQGFNFN-----------------VLVLGESGSGKSTLVNTLLNRD-----------------VYPPTQKSLTGDFGVNPEPTVM-----------INSSAVEIVENGISLQLNVIDTPGF-----DFIDNTDCWQPVLTDIEGRVHACIFFIQP----TGHAISAMLRVMLALHEKVNIIIAKADTLTDDELNFTKEMILRDIQY......................................................................................................................................................................................................................................................................................................................... 266
44 -11.300[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  21  15..............................................................................................IVLLGEGCVGKSSLVLRFVENKFSC-------------------------------------KHLSTIQASFQNK--TVNVEDCQAD-LHIWDTAG--------QEK---YHALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCLGNILIVGNKIDLEEERQVTRQDAE................................................................................................................................................................................................................................................................................................................................ 141
45 -11.300[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  20  1...................................................................................MSMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPP-------------------------------------GQGATIGVGF--MIKTVEINGEKVK-LQIWDTAG--------QER---FRSITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYSNKVITVLNKIDLAERREVSQQRAE................................................................................................................................................................................................................................................................................................................................ 138
46 -11.300[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  21  25..............................................................................................ILIIGNSSVGKTSFLFRYADDSFTP-------------------------------------AFVSTVGIDF--KVKTIYRNDKRIK-LQIWDTAG--------QER---YRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYWDNAQVLLNKCDMEDERVVSSERGRQL.............................................................................................................................................................................................................................................................................................................................. 153
47 -11.200[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  12  1...................................................................................MVEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAE-------------------------------------LSDPTVGVDFFARL--IEMKDGTQIKLQLWDTAG--------QER---FRSITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHPHRPVFALCKLDLINAGG----------EVTTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRS............................................................................................................................................................................................................................................................................... 181
48 -11.200[P] COG0370 Fe2+ transport system protein B  ali follow..  12  2..........................................................................................SQNTYCILGNPNTGKTSLFNALTGSY---EYVGNWS----------GVTVEKKVGTL---------------------------------KTGKLIDLPGIYDLNPISRDETVVTRFLLE---EKFDCMLNIVDSSQIERN-----LTVQLLEYGAPVVMGLNMIDVAAGRGIHLNIQNLAKKLR-------IPILPVVA----------------RSGKGTEDILSTLSEKHVAPAIPLVLQYGEPAEKAIKEIQALTKELIPAKQSRWLAIQFLSKNEVTEAFLTSNSAFEQLQQIRAELESELNGKLENHFHQVRASYIHDICLTSVEYTRNSDIPLSDKLDKIFTHKLLGIPIFLGIMWLIFQITFTWVGAPLSDMLDGFIGGSLTDWVTSFLTTIGASGFIIDLVADGIIAGVGGVLVFV-----PQILVIFFFISVLEDSGYMARIAVVMDRVMEIFGLNGKAVPGIMAARSIEESKERTLTILVSPFMSCSA 433
49 -11.200[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  17  44..............................................................................................IIVVGMAGSGKTSFLCHTFDSKSHGYVVNLDPAVMSLPFGANIDIRDTVKYKEVMKQYNLPNGGILTSLNLFATKFD-------VVSVIELVDTPGQIE---------FTWSASGAIITEAFAVVTYVVDTPRSSSPITFMSNMLYACSILYKTRLAFNKTDVADHKFALE.................................................................................................................................................................................................................................................................................................................................... 223
50 -11.200[R] KOG0394 Ras-related GTPase  ali follow..  15  11..............................................................................................VIILGDSGVGKTSLMNQYVNKKFSN-------------------------------------QYKATIGADFLTK--EVQFEDRLFT-LQIWDTAG--------QER---FQSLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASPFVLIGNKVDV-KAKAWCASKGNIPYFETSAKVGTNVEEAFQ............................................................................................................................................................................................................................................................................................................. 170
51 -11.100[R] COG0523 Putative GTPases (G3E family)  ali follow..  17  1........................................................................................MTPIAVTLLTGFLGAGKTTLLRHILN----------EQHGFKIAVIENEFGEVSVDDQLIGDRAT----QIKTLTNGCI----CCTRSNELEDALLVIECTGMAD------------GPIIQTFFSLLDGVIALVDAVHANEQNQFTIAQSQIGYAD---RILLTKTDVAGDSEKLRERLARINARAPVYTVVH................................................................................................................................................................................................................................................................................................................... 187
52 -11.100[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  20  1...................................................................................MSTKSYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTP-------------------------------------SFITTIGIDF--KIRTIELDGKRIK-LQIWDTAG--------QER---FRTITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHASEKILIGNKCDCEDQRQVSFEQGQAL.............................................................................................................................................................................................................................................................................................................................. 140
53 -11.100[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali follow..  20  38..............................................................................................LMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQKQTVKLEASTVEIEERGVKL-------------------------------RLTVVDTPGF----GDAIDNSNSFGAILEYIDERIHCCFYFISP----FGHGLKPLVEFMKKLHSKVNIVIAKADCLTKKEILRLKCRIMQEIES......................................................................................................................................................................................................................................................................................................................... 203
54 -11.100[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  20  3....................................................................................QEDEYDYLFKTVLIGDSGVGKSNLLMRFTRNEFNI-------------------------------------ESKSTIGVEFATRN--IVLDNKKIK-AQIWDTAG--------QER---YRAITSAYYRGAVGALIVYDITKQSSFDNVGRWLKELREHADSIMLVGNKTDLLHLRAVSTEEAQ................................................................................................................................................................................................................................................................................................................................ 139
55 -11.100[R] COG3911 Predicted ATPase  ali follow..  17  9..............................................................................................FVLTGGPGSGKTTLIAALRRAGFA---------------TSVVAGRGIVRDQSSIGGTALPWSDRTLFAELMLSWEMRSYQNAVEQKGPVFFDR-GVPETLGYLRLSGLPVADHVSTAAKRYNPRVFIADEERKQTPDEAKCTYHALAPVETRLRFVLADAG............................................................................................................................................................................................................................................................................................................................................. 181
56 -11.000[R] COG1341 Predicted GTPase or GTP-binding protein  ali follow..  13  2......................................................MRMASNKAMFTNDVPQDRLLAVEKIESL-------RKPAKVMIIGDVDTGKTTLTIYLANE----LSRGFRVA---IIDSDIGQKGILPPATISLAFVDSHFTSLDDLKAFFIGTITPNQYFGEMVVGVMLIDTTGMIYGS------GVELKRMKIEAVKPNLILALERNNELAPILKGYEDITIRLEVSEKAKDFSRSERRELRREKWRKYF.................................................................................................................................................................................................................................................................................................................................. 211
57 -11.000[J] KOG0458 Elongation factor 1 alpha  ali follow..  15  74LKKTLKKKKTPKKPIAAANGSANVTQKLANISISQQRPNDRLPDWLDEEESEGERNGEEANDEKTVQRYYKTTVPTKPKKPHDISAFVKSALPHFVVLGHVDAGKSTLMGRLLKLQRESETMGKSS---KFAWIMDQTNEERERGVTV---------CTSHFSTH---------------ANFTIVDAPG-------------DFVPNAIMGISQADMAILCVDCST-GQTKEHMLLASSL----HNLIIAMNKMDNVDWSQ--QRFEEIKSKLLPYLVD..................................................................................................................................................................................................................................................................................................................... 338
58 -10.900[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  15  4....................................................................................APYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMA-------------------------------------DCPHTIGVEFGTRI--IEVSGQKIK-LQIWDTAG--------QER---FRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPIILIGNKADLEAQRDVTYEEAK................................................................................................................................................................................................................................................................................................................................ 140
59 -10.900[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  14  60.........................................................................................EVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNK----------------------------------------ICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGT--------GALIFVIDSQDDYMEALARLHLTVTRAYKVNFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTS-IYDHSIFEAFSKVVQKLIPQLPTLEN............................................................................................................................................................................................................................................................................ 246
60 -10.900[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  18  9..............................................................................................YIIIGDTGVGKSCLLLQFTDKRFQP-------------------------------------VHDLTIGVEFGARM--VTIDGKQIK-LQIWDTAG--------QES---FRSITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHSNSIMLIGNKSDLEARREVKREEGE................................................................................................................................................................................................................................................................................................................................ 135
61 -10.900[DTZ] KOG1547 Septin CDC10 and related P-loop GTPases  ali follow..  13  210.QPPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMK---QGFEFN-----------------IMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGV---------------------------------KLTVIDTPGF-----DHINNENCWQPIMKFINDRVHCCLYFIPA----TGHSLRPLIEFMKRLSKVVNIVIAKADTLTLEERVHFKQRITADLLS......................................................................................................................................................................................................................................................................................................................... 449
62 -10.900[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  18  11..............................................................................................FLVIGSAGTGKSCLLHQFIENKFKQ-------------------------------------DSNHTIGVEFGSRV--VNVGGKTVK-LQIWDTAG--------QER---FRSVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLSPNIVVILNKKDLDPEREVTFLEAS................................................................................................................................................................................................................................................................................................................................ 137
63 -10.600[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  16  15...................................................................LSRQDLTTLDVTKLTPLSHEVISRQATINIIGHVAHGKSTVVKAISGVHTVRFKNELE--------------------RNITIKLGYANAKIYQLDDPSCPRPECYRSNFRLVRHVSFVDCPGMLNG------------------AAVMDAALLLIAGNEQPQTSEHLAAIEIMK---KHILILQNKIDLVKERQAKEQYEQILAFVQGT........................................................................................................................................................................................................................................................................................................................ 214
64 -10.600[R] COG2262 GTPases  ali follow..  17  157....................................................ETQLETDRRLLRNRIVQIQSRLRVEKQREQGRQSRIKADVPTVSLVGYTNAGKSTLFNRITEAR--------------------------------VYAADQLFATLDP---------TLRRIDVADVGETVLADTVGFIRHLPHDLVAA--FKATLQ--TRQATLLLHVIDAADVRVQENIETVLEEIDAHEIPTLLVMNKIDMLEDFE....................................................................................................................................................................................................................................................................................................................................... 326
65 -10.500[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  21  3...........................................NEATLAESIRRLRQGERATLAQAMTLVESRHPRHQALSTQLLDAIMPYC-RLGVTGTPGAGKSTFLELLIREGLKVAVIAVDPSSPVTGGSILGDKTRM---NDLARAEAAFIRPVPSLGGASQRARELMLLCEAAGYDVVIVETVGVGQSETE--------------VARMVDCFISLQIA---GGGDDLQGIKKGLMEVAD--LIVINKDDGDNHTNVAIARHMYE.............................................................................................................................................................................................................................................................................................................................. 218
66 -10.500[R] KOG2203 GTP-binding protein  ali follow..  12  42.............................................................................................VVAIMGPQSSGKSTLLNHLFKTSFREMDAFAG-------------RSQTTKGIWMARCVGIE-------------------------PFTIAMDLEGTDGRERGEDDTTFE-KQSALFAIAVADIVLINMWCHDIGLKTVFQVMLRLFSPRKTTLLFVIRDKTKTPIELLERALREDIQKIWDSVRKPE................................................................................................................................................................................................................................................................................................................... 200
67 -10.400[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  13  6.............................................................................................IIGVGGPVGAGKTMLIERLTRY--KGYSMA----------AITNDIYTKEDARILLNTSVLPADRIAGVETGGCPHTAIREDASMNFAQLLFLESGGDNLSATF--------------SPDLVDFSIYIIDVAQ---GEKIPRKGGQGMIKSD--LFIINKVDLAPYVGA...................................................................................................................................................................................................................................................................................................................................... 159
68 -10.400[R] COG0486 Predicted GTPase  ali follow..  13  147.SSEQAARSALKSLQGEFSNKVNQLVDSVIYLRTYVEAAIDFPDEEIDFLADGKIEAHLNDIITQLDHVRSEAKQGSILRE------------KVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRD-------------------VLREHIHIDGMP----------------------LHIIDTAGLREATDEVERIGIVRAW-----IEQADRILLMLDSTE-ADNQDLEKVRSEFLTKNIPVTIVRNKADLSGENE....................................................................................................................................................................................................................................................................................................................................... 355
69 -10.400[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  18  2.....................................................................................NPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLD-------------------------------------SYISTIGVDF--KIRTVEQDGKTIK-LQIWDTAG--------QER---FRTITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYASEKLLVGNKCDLTSQKVVSTETAKAF.............................................................................................................................................................................................................................................................................................................................. 139
70 -10.400[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  18  2.....................................................................................DEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDP-------------------------------------ELAATIGVDF--KVKTISVDGNKAK-LAIWDTAG--------QER---FRTLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYRNDIVNMLNKIDK-EGLKFARKHSMLFIEAS.......................................................................................................................................................................................................................................................................................................................... 151
71 -10.300[C] COG1149 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain  ali follow..  16  2...........................................................................................KQVAVISGKGGTGKTTFSATICDVDAPNLHILLKPQILKAEDFIASKKARIMPEKCSSCGDLCRFGAVVAEDGYYVDEKKCEGCPERAIEEFLIVDSPGV--------------GCPVMASLTGVDAAIIVTEPTVSGL-SDMLRILELCEHFRIRPFVVVNKFDASEIESYCSENG-----VEFAGRVPFDKAIPEQIANLNFPFSGKAADKMVEIWKKLREVL................................................................................................................................................................................................................................................................................. 283
72 -10.200[J] KOG0459 Polypeptide release factor 3  ali follow..  15  11...QLESADENNGVVIPEVHNSHEVENLDKAPEDLKDEVQESIPVPDEQEASEDHDEVMLHPVHNPAKAKEKAAQEKAAKEEAEDVAEANKKRHLVFIGHVDAGKSTIGGQILKYEKEAKDKSRES---YMAYIMDTNEEERLKGKTVEV-------GRAHFETE---------------TRFTILDAPG-------------SYVPNMISGASQADIGVLVISARK-GQTREHVQLAKTL----SKLIVVVNKMDDPTVNWSKERYDEIEQKMVPFLKA..................................................................................................................................................................................................................................................................................................................... 274
73 -10.000[V] COG2274 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain  ali follow..  12  445.................................IRLDDVLDNPVGEVGGKTSSSSLQALPKL-QGYVELKNITFGYSRLEAPLIENFNLSIKPRVALVGGSGSGKSTIAKLVSG----------QPWTGE--IYFDSQPREEISLQLLTNSVAMVEQEILLFGGTVRDNLQDAAIADVIFS--AELIEGALSGGQRQRL-------EIARALVNNPSILVMDEATSALDAETE-KIIDQNLRRRGCTCIIVAHRLSTIRDCDQIIVLGKVV.............................................................................................................................................................................................................................................................................................................................. 689
74 -10.000[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  19  20..............................................................................................ILILGLDNAGKTTFLETLKKEYSLAFKEKIQPTVG----------------------------------------QNVATIPVDSKQILKFWDVGG-------------SLRSMWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEPILMLANKQDRQDRMEVQDIKEVF............................................................................................................................................................................................................................................................................................................................... 150
75 -9.960[S] COG3523 Uncharacterized protein conserved in bacteria  ali follow..  11  123...........................LRMDEQLLRRFLHPRGEEVPVAGEIKADLRTVNHIVTQAIRQLRQLRVDMPGWRKIFEGKRLYELPWFMVVGSPGDGKTTALL----------NTGLQPLAEQME----QTSRILTVPGGGTLHCDWWFT-----------------------NEAVLIDTAGRYARHDDGGEASAAQRNAGEWFLGLLNGVILTLNVADLAACAALRARLAELRGIRFPVYLVVTKMDLLPG------FSEYFRTLTSHLRAQIWGFTLPYSRRRKAGDPQALHAACAQELARLTLRLDQGLDTRLQEEYDLKSRQR.............................................................................................................................................................................................................................................................. 412
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Harder T, Godzik A. JAFA: a protein function annotation meta-server. Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W379-81.