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Query: [T] KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MIKQIFGKLPRKPSKSSHNDSNPNGEGGPSSKSSASNSNGANGTVIAPSSTSSNRTNQVNGVYEALPSFRDVPTSEKPNLFIKKLSMCCVVFDFNDPSKNLREKEIKRQTLLELVDYIATVSTKLSDAAMQEIAKVAVVNLFRTFPSANHESKILETLDVDDEEPALEPAWPHLQVVYELLLRFVASPMTDAKLAKRYIDHSFVLKLLDLFDSEDQREREYLKTILHRIYGKFMVHRPFIRKAINNIFYRFIFETEKHNGIAELLEILGSIINGFALPLKEEHKLFLIRALIPLHRPKCASAYHQQLSYCIVQFVEKDFKLADTVIRGLLKYWPVTNSSKEVMFLGELEEVLEATQAAEFQRCMVPLFRQIARCLNSSHFQVAERALFLWNNDHIRNLITQNHKVIMPIVFPAMERNTRGHWNQAVQSLTLNVRKVMAETDQILFDECLAKFQEDEANETEVVAKREATWKLLEELAASKSVSNEAVLVPRFSSSVTLATGKTSGSLast
1 -101.000[T] KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit  ali  100  1MIKQIFGKLPRKPSKSSHNDSNPNGEGGPSSKSSASNSNGANGTVIAPSSTSSNRTNQVNGVYEALPSFRDVPTSEKPNLFIKKLSMCCVVFDFNDPSKNLREKEIKRQTLLELVDYIATVSTKLSDAAMQEIAKVAVVNLFRTFPSANHESKILETLDVDDEEPALEPAWPHLQVVYELLLRFVASPMTDAKLAKRYIDHSFVLKLLDLFDSEDQREREYLKTILHRIYGKFMVHRPFIRKAINNIFYRFIFETEKHNGIAELLEILGSIINGFALPLKEEHKLFLIRALIPLHRPKCASAYHQQLSYCIVQFVEKDFKLADTVIRGLLKYWPVTNSSKEVMFLGELEEVLEATQAAEFQRCMVPLFRQIARCLNSSHFQVAERALFLWNNDHIRNLITQNHKVIMPIVFPAMERNTRGHWNQAVQSLTLNVRKVMAETDQILFDECLAKFQEDEANETEVVAKREATWKLLEELAASKSVSNEAVLVPRFSSSVTLATGKTSGS 506
2 -12.200[A] COG5181 U2 snRNP spliceosome subunit  ali follow..  733IVERVVNNFKDESEPYRKMTAETVDKVIGSLGVSEIDERLEELLLDGVLFAFQEQSVEEKVILTCFSTVVNALGTRCKPYLPQIVSTILYRLN--------KSANVREQAADLVSSITIVLKACGEEALMRKLGVVLYEYLGEEYP----------------------------EVLGSILGAIKAIVSVVGMSSMQPPIRDLLPRLTPILRNRHEKVQENWMRICFELIDMLKAHKKSIRRAAVNTFGYISKAIGPQDVLATLLNNLKVTTVAIAIVAETCMPFTVVPALMADYRTPEMNV--KSLAFMFEYIGEQARDYVYAITPLLADALMDRDAVHRQTAASVIKHLSLGCVGLGVEDAMIHLLNILWPNILEESPHVINAVREGIDG--IRNCIGV--GPIMAYLVQGLFHP-----SRKVRNTYWTSYNSAYVQSADAMVPYYPHVDDDQFNNYDMKT.......................................... 1183
3 -11.100[YU] KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily)  ali follow..  10  13...........................................................................................................................................................................................................VIQLLQHAHSTDRDVQRNVQVQLVQLNEH-----QKFCCYLVYILSDMKEMIDATSRSLAGL-LLKNNIRAKWNKYPQDVKFFVRTTCLKSIGDQE-PLIRATVGIIVTTIVMEEMCDWPDLLDTLATVLMQPDELMQEGALGALQKVFEDSADRYESEFLRPIMPKLLVFYEHHAAKMRALAMNCVNC--ILMVNNDPIDFAIDQFLTSLFARHND--DEEVQKQLCRSLTLLLDMMPHLPNVIEYIIKKTQDHNESIALEACEFWLSIAENSDICRTMVL..................... 290
4 -10.900[U] COG5064 Karyopherin (importin) alpha  ali follow..  2......................................ESRYLSDRRSRFKSKGVFKADELRRQREEQQIEIRKQKREESLNKRVLQNDIDVEEEADQSQVQMEQQMKDEFPKLTADVMSDDIELQLGAVTKFRKYLSKETHPPIDQVIACGVVDRFVQFLES--------EHHLLQFEAAWALTNIASGTTDQTRIVVDSGAVPRFIQLLSSPEKDVREQVVWALGNIAGDSSACRDYVLGNLQPLLNILQSSASDVSMLRNATWTLSNLCRGKNPPPNWSTISVAVPILAKLLYSEDVEIIVDAC--AISYLSDGPNEKIGAILDVLVELLSSPSVNIQTPALRSVGNIVTGTDAQTQIIIDCGALNAFPSLLSHQKENIRKEACWTISNPPLVHLLSYADYKTKKEACWAISNATSG--DNKIIQVALDAIENILKVGEMDRTMDLENINQYAVYSSGNNDIYLKAYSIIEKYFSDEDAVEDLAPETENGAFTFGNGPQAQGE 529
5 -10.800[U] KOG0166 Karyopherin (importin) alpha  ali follow..  1.....................................MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKR-EEVMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARF-------------ENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADAC--ALSYLSDGPNDKIQAVIDALVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNPALISILQTAEFRTRKEAAWAITNATSGG-DSKIVQVALNGLENILRLGEQEAKRNGTGINPEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPM 533
6 -10.000[U] COG5096 Vesicle coat complex, various subunits  ali follow..  12  7....................................................................................................VQQDFLEAPSVDALKTSLESKNDYVKISAMKTILRVVINHVIRFVMPSRNKELKKLLYYYWEVCPKYNNDGTMKQEMILACNSFRNDLQHPNEFIRGALLDPLIPTVRQCLEHRHAYVRKNAILAVFSIYQVSNHLIPDAASLAEDFLAAESEGTCKRNALIVLLVIIEFIRKVVLTKADGLEKLRFQSLLVSLTATNNSSVVFEAA-TSVINVFPDAESLKLAASRLLALADREADNNAKLIMLDRISQLAAR------KSILEDLITDVIPFLSSSDFDVCEKAISIISSRNVEDILNHFQKELRRALTKAIHSCAINF-QSKSASSVLSFIKEVMEKFPDLRSSNITKLLLSLKELRAGKIFRGVIW-IAGEYCLT........................... 460
7 -9.970[U] KOG1062 Vesicle coat complex AP-1, gamma subunit  ali follow..  10  1....................................................................MNPFSSGTRLRDMIRAIRACK---------TAAEERAVVRKECADIRALINEDDPHDRHRNLAKLMFITHFGQMECLKLIASPGFPEKRIGYLGLMLLLDERQEVLMLVTNSLKQDLNHSN--GNICSAEMARDLAPEVERLIQFRDPNIRKKAALCSTRIIRKVPDLAENFVNAAASLL-----KEKHHGVLITGVQLCYELCTINDEALETKCTEGLIKTLRDITNSAYQPEYD-RLLRLLRVLGQGDADASDLMTDILAQVATKTESNKNAGNAVLYECVETIMAIEDTNSLRVLAINILGRFLSNRDNNIRYVALNMLMRVTILECVKDPDASIRKRALELVTLLVNE---NNVTQLTKELIDYLEISDEDFKEDLSAKICFIVEKFSPEKL-----WDQMLKVLCEAGKFVKDDVWHALIVVISNASELHGYT 459
8 -9.890[YU] KOG1241 Karyopherin (importin) beta 1  ali follow..  66QLKNHLTSKDEKVSQQYQDRWHQFPSEIRELIKNNILAALGTENTRPSCAAQCVAYV----------AVIELPINRWPMLIQTLVNKV---------VSEGSSEMHRESALEAIGYICQDIRFGVMENQSNDVLTAIIHGMRKVEPSNHVRLAA-------------------TTALHNSLEFT------KSNFEKDMERNFIMEVVCEATQCQDSQICVAALQCLVKIMTLYYQYMEPYMAQALFPITLAAMKSDNDAVALQGIEFWSNVCDEEIDLAIESQEATDQGRAPQRVSKHYARGALQFLTPVLVEKLTKQDEIVPHVLPFIKENIESPNWRFRDAAVMTFGSVLNGLETNTLKPLVEQAMPTLIRLMYDSSVIVRDTIAWTFGR--ICDIIPEANETYLQTLLECFVKSLKS--EPRVAANVCWAFIGLSDA-EYIITQLLETTDRSDGAQANLRCAAYQALMDMIKNSPLDCYLVVQRTTLVILERLNQVMQMETQI 573
9 -9.800[U] COG5215 Karyopherin (importin) beta  ali follow..  64TLKNELVSKDSVKTQQFAQR---------TQVSPEAKNQIKTNALTALVSIEPRIANAAAQLIAAIADI-ELPHGAWPELM-------KIMVDNTGAEQPENVKRASLLALGYMCESADPQSQALVSSSNNILIAIVQGAQ-----------------STETSKAVRLAALNALADSLIFI---------KNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSLYYTFMKPYMEQALYALTIATMKSPNDKVASMTVEFWSTICE--EEIDIAYELAQFPQSPLQSYDDWNVSMSAGACLQLFAQNCGNH--ILEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMNDQSLQVKETTAWCIGRIADSVAESIDPQQHLPGVVQACLIGLQD--HPKVATNCSWTIINLVEQ-YNFYPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTV...................... 535
10 -9.210[S] COG5369 Uncharacterized conserved protein  ali follow..  13  259.............................................................................................................................................................................LDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKA-KNQTKEIQMIVTPILIRLFFESRE----QIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYAT-ELQSSAACECLLSLSRSVYILRTGLADALIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCND--DLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMEEKLESKNPILIEPSIYILVHIAASDGELRDSIL.................. 596
11 -9.210[R] KOG1293 Proteins containing armadillo/beta-catenin-like repeat  ali follow..  13  259.............................................................................................................................................................................LDEIENVFEGNKDKVALFKSEIFGPNGDEYITQLFCLVRQFDPCIRLLSISCLVTLYKA-KNQTKEIQMIVTPILIRLFFESRE----QIAPRILAIIINENEIMQKTAVNAGFIDAAKYLLEYAT-ELQSSAACECLLSLSRSVYILRTGLADALIKLLSDPDTRVKSTATSAICNLVLKFSPLREKFLTTNFIDTLISNISTKDSSLRKKTVWVLRHVVFGDDETIQLEPLKKIGASKLVELCND--DLGVQEQMLQVLRNFTCQKEESVDFLLKMVPMEEKLESKNPILIEPSIYILVHIAASDGELRDSIL.................. 596
12 -9.140[U] KOG1058 Vesicle coat complex COPI, beta subunit  ali follow..  12  1................................................................................MSSGEQPCYTLIHVPSDAELPSEAQLRIEALKKLIYMILNGEKTSQSMLMYVIRFCLPSN------EHTLKKVLLIFWECVPKTDSNGKLLHEMILVCDAYRKDLQHPN--CKLREPELLEPLMPAIRACLEHRHSYVRRNAVCAIFTIYKNFEFLIPDAPELVTEYLEQEQDASCKRNAFMMLLHVIVELIYKVCHNNPNEASRFIRCVYNLLQSSSPAVRY--EAAGTLVTLSNVPAAVKAAASAYIDLIVKESDNNVKLIVLDRLVALRGSSSN---EKILQGLVMDILRVLSSPGLEVRKKTLSLASSRNVEDMVMFLKKEINKELVKTLHAATIKF-NEKASSYVLQFVREAVHKLPNLKNAILGALREGIPFIQSPTIFMSALW-ILATYCEA........................... 468

FFAS is supported by the NIH grant R01-GM087218-01
1 4 3 0 4 3   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Zhang Y, Stec B, Godzik A. Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure. 2007 Sep;15(9):1141-7.