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Query: [L] KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTRDEDNGFSEWGGYFEAKKSKLEEQFAAASDPFRKSDLFQGISIFVNGRTDPSADELKRIMMVHGGTFHHYERSHTTYIIASVLPDVKVRNMNLSKFISAKWVVDCLEKKKIVDYKPYLLYTNQKTSQPMLIFGKPKDNGANESKSDVEPPKDKAEVEVDSTKDETQMELGGILKNLQQAVATSPEKEASASESKITNLSTTSNNSTTARTAADPNFLSEFYKNSRLHHIATLGAGFKQYVCRLRQKHGTQGFPKRETLKSLANSHHNCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTIPYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHELNVDVMAFVSHLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQFLLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQAGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIRFTNSVECEQFLCQLSEEVTKRLVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDIINKSSLIKYATDDVNVITTVVLDLMKDADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSEMRKDKPIPQGAVGDKSIGDDKVNKPLVFENKPKPREPRNVLSMLTAAAVSRKSVTEDRSQRGTSKPITRPLSLVPKLDEDVLAQLPEDIRLEVIANREEHLCIAEYDGYRSPQYPTLRSPPLLNPYVTTNVSPLKATDLKPSTSRAAVARLQKRKERKEQEHYIRSDQIVADYIDDLPDFVNPHILKLISHPVEMPELLMGDNYKDLLNDWVSREEVPKPNDVDLILKQVSRMIKNDQLDHVCDVMKYWCRIINMKRSSSCCWHVAYKHIEESIQNQMLTIEGYSLLFIEYIRCIKCSLast
1 -217.000[L] KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase  ali  100  1MTRDEDNGFSEWGGYFEAKKSKLEEQFAAASDPFRKSDLFQGISIFVNGRTDPSADELKRIMMVHGGTFHHYERSHTTYIIASVLPDVKVRNMNLSKFISAKWVVDCLEKKKIVDYKPYLLYTNQKTSQPMLIFGKPKDNGANESKSDVEPPKDKAEVEVDSTKDETQMELGGILKNLQQAVATSPEKEASASESKITNLSTTSNNSTTARTAADPNFLSEFYKNSRLHHIATLGAGFKQYVCRLRQKHGTQGFPKRETLKSLANSHHNCLERYVMHIDMDCFFVSVGLRTRPELRGLPIAVTHSKGGNAATDVPVHPQADRKAELELFAQRFEHHFHDGDKAEKVRSGFDKKMSLSEIASCSYEAREKGIRNGMFVGQALKLCPELKTIPYDFEGYKEVAFTLYDTVAQYTLNIEAVSCDEMFVELTDLAHELNVDVMAFVSHLRQEVYSKTGCPCSAGVAGNKLLARMATKEAKPNGQFLLDSSNDILAYMAPMSLDLLPGVGSSISHKLKQAGLNNCGDVQNTTLEKMEKVLGKKLGQNLFQNCRGIDDRPLAYEQIRKTVSAEMNFGIRFTNSVECEQFLCQLSEEVTKRLVEIRRKARSINLKIMVRAAEAPVETSKYMGHGVCDIINKSSLIKYATDDVNVITTVVLDLMKDADIPPDELRGLGIHLTRLEDANEVRKENNIKEMFGKMSEMRKDKPIPQGAVGDKSIGDDKVNKPLVFENKPKPREPRNVLSMLTAAAVSRKSVTEDRSQRGTSKPITRPLSLVPKLDEDVLAQLPEDIRLEVIANREEHLCIAEYDGYRSPQYPTLRSPPLLNPYVTTNVSPLKATDLKPSTSRAAVARLQKRKERKEQEHYIRSDQIVADYIDDLPDFVNPHILKLISHPVEMPELLMGDNYKDLLNDWVSREEVPKPNDVDLILKQVSRMIKNDQLDHVCDVMKYWCRIINMKRSSSCCWHVAYKHIEESIQNQMLTIEGYSLLFIEYIRCIKCS 995
2 -78.200[L] KOG2095 DNA polymerase iota/DNA damage inducible protein  ali follow..  17  2................................................................................................................................................................................................................................................................................................................SSARSHVSMQNKYDRVVLLVDMDCFFCQVEEKQHPEYRNRPLAVVQYNPWRGGGIIAVNYAARAKGVTRHMRGDEAKDLCPEIVLCQADTSKYRDAGKEVANVLQRFTQLLERASVDEAYLDITETVNHRMQQGASVAGEVRAAVKKETGYECSAGIAHNKILAKLAAGMNKPNKQTILPL-TETASLFDSLPVGKIKGLGGKFGEVVETLGIKFMGQVVKFSEVDLQRKFDEKNGTWLFNISRGIDLEAVTPRFYSKSIGCCKKFPGRITGLKTLQHWLGELSSEINDRLEKDFIENNRRAKHMVV----------QYVQDIDGEEVASSRSTALRDYDQESIVRLSLDLIKANTKTNNAIKFLGISVGKFETVSS--GQNKLQEMFANQAAKKRRVSGDEPGQLPKVEMEKKQKQTDEFKMKSFFANYLQGAKKEDAKADGISANPLAAAAGAPNKNYKHKLHAAVRTEGTVLTSTPAEFKESFFSQYLKQQKKTGQQGSVTSREDSLDVQELAEELDAIEADNSKDFEEDTEEETELTSDTHMSKPEGQSSDAGQEQ................................................................................................................................... 638
3 -78.000[L] COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair  ali follow..  26  2..............................................................................................................................................................................................................................................................................................................................RKIIHVDMDCFFAAVEMRDNPALRDIPIAIGGS-RERRGVISTANYPARKFGVRSAMPTGMALKLCPHLTLLPGRFDAYKEASNHIREIFSRYTSRIEPLSLDEAYLDVTDS-VHCHGSATLIAQEIRQTIFNELQLTASAGVAPVKFLAKIASDMNKPNGQFVITP-AEVPAFLQTLPLAKIPGVGKVSAAKLEAMGLRTCGDVQKCDLVMLLKRFG-KFGRILWERSQGIDERDVNSERLRKSVGVERTMAEDIHHWSECEAIIERLYPELERRLAKPDLLIARQGVKLKFDDF---------------QQTTQEHVW--PRLNKADLIATARKTWDERR-GGRGVRLVGLHVTLLDPQMERQLVLGL................................................................................................................................................................................................................................................................................................................... 351
4 -69.600[L] KOG2094 Predicted DNA damage inducible protein  ali follow..  15  15..........................................................................................................................................................................................................................................................................DKEKITKVIEENTSASYSSFSKKQQSLEIKNRLQTATREERQKSEILMEN-SRDCVCIDMDAYFAAVEMRDNPALRTVPMAVG-----SSAMLSTSNYLARRFGVRAGMPGFISNKLCPSLTIVPGNYPKYTKVSRQFSQIFMENENTLEDLKIEESICPKCEKSREFGTGREEAVREIRFRVEQLTGLTCSAGIASNFMLAKICSDLNKPNGQYVLENDNAIMEFLKDLPIRKVGGIGRVCEAQLKAMDIQTVGDMNLKKNLYPLCFTP-LSQESFLRTALGLPGRPSESDPRRKSISVERTFS-PTSDFNILLEEHQEICRMLEEDVRKSGVGGKTVTLKLKLSSF---------------DVLTRSLTPSDVVKSLEDIQKFSLELLEKEK--GKEIRLLGVRLSQLIFEEDEKKRSK---------TVCQKILKTITDKYKAMFSSIFLRHFISDHRV........................................................................................................................................................................................................................................................................... 516
5 -14.900[L] KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component  ali follow..  100.......................................MDGLKVLASGFLVDEKVKIKELVTSMGGVLLSRASSDVNFVIVKNVLAAKYKWALNKPIVTLNWLHRCWNEHRVVPQEPYKIPPFSGLTICVTRIPAGDKYKVARKWGHIQIVTRKWFQQSIDKKVCLNEESYPVLGSIPLTRGVRDLGVHNGLEKFPSAATASAADSYVSCAQSRDSDIEA----------------------------------------------------------------------SASQNVFPTSMNPSTDVKEPGGGPTARPQEQNIDGCTARDSESEDNDLYLSDCRIFLLGFEASEMRKLAKL---VRRGG---GSRYMLLNERMTHIVVGTPSEREARSVAAS------GVIQVVIPSWLEDCDREKKEIPVHNIYTANHLILPRDSACLTKGSFARMSSMEQTKNTHDQTMVGCSP------LPCQTPLPGFESLCI--SSQHNEKNVELLRNLSVVLGADFVERLTRKVTHLICNFAKGDKYVRASKWGIISVTPDWLYECVRQNQVVCTDNFHPRELTTQDREAGSQFHTQFVPMASRDSMSLPVSHSEDREKIQSFAGKSGCGKGEVYNRLGEIGKEQTFPSKKAKLLRDGQESDVFPVRELPSNCDRPSHSGDGIVTGYDVASGREVPDVADTIEDLLEQTSKIQDQKSPGRILEKTVSLNEQYNTGNHSVTGLSRHWINRVHKNDDMGSPPGDATTDTYGNFSETQTESQVVGYEEDLSGRQMLIDRVRTRSSLT.................................................................................................................................................................................................. 783
6 -12.200[KTDL] KOG2043 Signaling protein SWIFT and related BRCT domain proteins  ali follow..  12  96....................................CQIFFGITACLSQVSSEDRSALWALVTFYGGDCQLTLNKKCTHLIVPEPKGEKYEKRASIKIVTPDWVLDCVSEKTKKDEAFYHPRLIIYEEEEEEEEEEEEVENEEQDSQNEGSTDEKSSPASSQEGSPSGDQQFSPKSNTEKSKGELMFDDSSDSSPEKQERNLNWTPAEVPQLAAAKRRLPQGKEPGLINLCAN-PGNILPPEVRGNLMAAGQNLQSSERSEMIATWSPAVRT................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 337
7 -11.200[T] KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE)  ali follow..  67CGNFDSDLFRTLTKHQETQALFI-LKNEDLMTLRAARPLYKDVTMKLAAEVP-NKRELVDLVHYMGGSVRKDTVSRTNVFIAAKVEAKQSISLVGVPTMRADWVTECVDKHRLGVFEGLSLFFHGFKQTEIDDMLRSLENTGGKLAPSPTLATHVVYNPDNDEVETLAVSSNQVHVTKEWFWVSLHRGCCAIEDNFALPTGKLHRKPLESSSVSSPIGKSLRSQNSR----SLSSMRDCSVEGPTSLNMTPDYIYSNDDVENSCKSPRQPSKRLRVCMEM----VETEKNYLSLLK------------EALECEISHNEFMSRSDVAMMFGKLD-----------------------PILELHER------------------------IFARLTVMSNEANTLLTVVNGKKNDDKNLDFAQVWIDAKEEMKKAYPQYINSYDTIKRLFDKQDR-------ENSKFHTFCKAKESNPE--LMVKPVQRLPSV--ILLLKEMAKKSDSKLKNNAEEAAKAIDEVLKTANKTREKN---DNFISHLSKFTDIENVPPILVAANRMFIREASTSPGLQQFAKMKLFLFHDVLIITKIRSEKNTMQRLARHASFASLHSRQRRPYRYIDQIQLNTMRSAFRIRAPDEIAKCLELQQQNGSTKPNVFVWCLIHRDEQGGDIDTVFESNDDEEVRDFLDDIHVKILSDCGRFFYSSDPSINDAMVSDMTTRYFRNLCGAKPQYGHGSQMNITEWSHNESFMPPPQSQSRMRRAFSNAQLTLATTLGFGRNQSRNNLGQINENTTFLQSPRVSCDPAALANMTSVGGLPGCQSESESTPKRGIRSRLTSTTFLGGRHNILGRNTSMRRQATGFAHS.............................................................................................................................. 907
8 -10.200[K] COG5190 TFIIF-interacting CTD phosphatases, including NLI-interacting factor  ali follow..  11  461...........YEEENDISSRSGNHKHANVGLPKMKQKVLKGCRLLFSG-VDVLSSDIAKWAMSFGAEVVLDFSVPPTHLIAAKIRTEKVVSMGNIKVVKLNWLTESLSQWKRLPESDYLLYPSYDLPDRNLSEHSYSSSSDDEQRISELNDRELDEIDWQAADQDVENALKDLSDDNDFDTGSISASQSQPEALEVNTPIKRKADLIQPSYNYDGEKRRKENDNHEGYDLLPNSSTKGEESAENENELDDLADIMEAELSKD............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 721
9 -7.890[O] COG4934 Predicted protease  ali follow..  88ATEISMPGSPLYRHWLTTQ--QINSMFGNYQGVETVSSYFSGFSVAISG----NASMMESVF---HTTIYYFTNKNGQVLFSNL---------NSIEL--PGSVARYVLS--VDGLSNF---------------------QMTTNPVYPTLSDYTSSGLIKNFEPLSSGTQSYLNHSDVVGFYAKKYAWVQLPLTNGPYPGSNVTGYTPPFQALFPSDLPWIYNIAPG------------LNGTSSTPGANGTGTTIAIVMGTGYINATLAYPAWNYNDMLKYGKEV----NPSQILSRVTYLNAPGITHSPPPDPSPSF-FTLDTQY--AHLDIMAIPSLSTVALDNAYIELPNTPQVITNSW-----SGSEDS--------------WWNMYGPYWQSADLMNLLFELLS--MKGSTIVAATGD--------SGGYDGYTNMISGEFPGTSPWVTGVG-GDQVTMFN-ISTGAGSAALSIFQPWWQHGYSVPNTGRMSEVEVSAEAGFN-QTELVDGMWGSWFFG--------GTSEATPTTAGMIADVISYLNATIHVNYLG--------------INPLLYEIGNEYMQNPGKMPDPYFTVS-----------------NGTNSLSALMVNDSYTLDGPQNYPSNYYTTD---------SMLTGWGINVGNFKID............................................................................................................................................................................................................................................................................................................................ 733
10 -7.640[A] KOG2481 Protein required for normal rRNA processing  ali follow..  10  315.................HLVADNNKEVEEDEETRVCKSLFKDLKFFLS--REVPRESLQLVITAFGGMVFKEDDESITHHIIDKPSAGHLYLSRVY--VQPQWIYDCVNARIILPTEKYLVLSPFVDNEAEGYVPDYAETIKRLQAAARNEVLPLPGVGKEDLEDPQNLLYAGVMSRAEEAEAAKNKKKMAAQEKQYHEELKMEINGSKDVVAPVLAEGEGEESVPDAMQIAQEDADMPKVLMSRKKRKLYDAMKISQSRKRSGVEIIEQRKKRL................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 583

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Godzik A. Surface map comparison: studying function diversity of homologous proteins. J Mol Biol. 2001 Jun 8;309(3):793-806.