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Query: [O] KOG2158 Tubulin-tyrosine ligase-related protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNLKNSKFFKRIQELRHFSKEKIRKDREKRTHVVRALDMALNEQPCLDREWFSPEQSPPLQPMSPRRRMKKTRCLKRRTAADKQVDDNSPYYGPSSGENSPMPAEEAKLQGFIQLNNKTYRVECPTRVLNPPMNVDEERPASETKSTICVSNSRYAMIGKISKTLGYKLVKESKMWNILWSDSFPGVELFKNMKRFQQINHFPGMIEICRKDLLSRNLNRMLKIFPQDYKIFPKTWMLPADYGDAMNYALNHKRTFILKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYELCDNDDCGSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAWPVLKHNYHACFPGHDKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLGGGTSKPKIDAQKGSPDAQPVDVEPEAEDHGPLAQQIAWEESHLGNFRKIMPPPDLSKLDYYTRFYAQSHQVSIFAETAASKKREDLARKMRIQLEEKKAKQQQMLNGKAKRDARKRHTVLLPRAVREKNRINFFRLRENWSPGFISDAEERLRHTWLHMRAEAIRTLKITENIYSNLYETGLLTNTDMVVYPHLYHNLQHGYDIKRTPLast
1 -140.000[O] KOG2158 Tubulin-tyrosine ligase-related protein  ali  100  1MNLKNSKFFKRIQELRHFSKEKIRKDREKRTHVVRALDMALNEQPCLDREWFSPEQSPPLQPMSPRRRMKKTRCLKRRTAADKQVDDNSPYYGPSSGENSPMPAEEAKLQGFIQLNNKTYRVECPTRVLNPPMNVDEERPASETKSTICVSNSRYAMIGKISKTLGYKLVKESKMWNILWSDSFPGVELFKNMKRFQQINHFPGMIEICRKDLLSRNLNRMLKIFPQDYKIFPKTWMLPADYGDAMNYALNHKRTFILKPDSGAQGRGIWLTNDLKTIGPHERLICQTYIHRPLLIDGYKFDLRVYTLITSVDPLRIFVYNEGLARFATNKYVEPTPGNANDLYMHLTNYSVNKRNSHYELCDNDDCGSKRKLSAINNWMRRHNYDVEEFWSNVDDVIIKTVLSAWPVLKHNYHACFPGHDKIQACFEILGFDILVDWKLKPYILEVNHSPSFHTNEQVDREVKRPLIRDTLNLVSTVLADKRQILKEDRKRVKQRLLKIRGDPPVQRPRLGGGTSKPKIDAQKGSPDAQPVDVEPEAEDHGPLAQQIAWEESHLGNFRKIMPPPDLSKLDYYTRFYAQSHQVSIFAETAASKKREDLARKMRIQLEEKKAKQQQMLNGKAKRDARKRHTVLLPRAVREKNRINFFRLRENWSPGFISDAEERLRHTWLHMRAEAIRTLKITENIYSNLYETGLLTNTDMVVYPHLYHNLQHGYDIKRTP 720
2 -107.000[O] KOG2157 Predicted tubulin-tyrosine ligase  ali follow..  22  66.DNEEKPVQSPQKLAEEEPTSSEPSSKEALSGSTQQKIFLLKKPQQCDKSDKLTFSSPFKKILNRYSSSDTSISSEGEEPANSSENKSRVLKTSQNAINIKLATDLSNESGYESIAPAKTISNTEVIEEEDDAECGINMPASKLKITYKFHQTETKLLRKLFNVHGLTEVQENNNFNLLWTGVHMKLDIVRNLAPYQRVNHFPRSYEMTRKDRLYKNIERMQHLRGMKFDIVPQTFVLPIESRDLVVAHNKHRGPWIVKPAASSRGRGIFIVNSPDQIPQDEQAVVSKYIVDPLCIDGHKCDLRVYVLVTSFDPLIIYLYEEGIVRLATVKYD-RHADNLWNPCMHLCNYSINKYHSDYIRSSDEDVGHKWTLSALLRHLKLQSCDTRQLMLNIEDLIIKAVLACAQSIISACRMFVPN---GNNCFELYGFDILIDNALKPWLLEINLSPSMGVDSPLDTKVKSCLMADLLTCVGIPAYSPEMKSHYDQKWSRFRSSSCQRIA----------TFPSTSQKTKKSKKKGAAINLNLTGEEQRILRNARLQYSRRGGFVRIFPTDDS--MQRYGNFLDSANGIPISTPNVQSQ--TFQTPIIQHNYNQMLHQNLYSKDGRQKQDDNNEADRIWQYERALETDSEIPFVKKPTVEKCEVEGSNGSELTPFQARQTFSMYLESVLR.................................... 752
3 -10.400[HJ] COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase)  ali follow..  17  143...........................................................................................................................................................................................................GVVVLNDPEGLALAQNKLYFQSFPEI--RPTTLIS-RNVEEIRAFADTHPKGVIVKPLQGSGGKNVFKIGSSKETSLEGYLIAQAYLPA------KEGDVRFFMM----RPLMRDGQYAALRRVPAKG--------------LRSNIHANGTAEAVKVTDEI----VELAEMMRPKLVEDGMF------------------------------------------LVGLDIVGDK-----ILEVNVFSP-NILELTNVDFSDTIIEAVETKVSMQAASGGALSNRLLATL................................................................................................................................................................................................................................... 371
4 -8.140[R] COG1821 Predicted ATP-utilizing enzyme (ATP-grasp superfamily)  ali follow..  19  101..........................................................................................................................................................................................................SRAIAVTSKWELYKKLRG-----------VPQTSLRPLDCK------------FIIKPRTACAGEGIGFSDEVPD-----GHIAQEF------IEGINLSVSL---AVGEDVKCLSVNEQIINNFRYA---------------AVVPARISDEVKR----------------------------------EVVEEAVRAVECVEGLN-------------------YVGVDIVYSDQ--PYVIEIN--ARLTTPVAFSRAYGASVADLLAGGE..................................................................................................................................................................................................................................................... 271
5 -7.630[T] KOG0696 Serine/threonine protein kinase  ali follow..  14  332..........................................................................................................................................................................................................................GNRDRMKLTDFNFLM-SF------KVMLSERKGTDELYAVK-------KDVVIQDDDVECTMVEKRVLALPGKPPFLTQ-FQTMDRLYFVMEYVNDLMYHIFKEPHAVFYAAEYRDLKLDNVSEGHIKIADFGMCKENIWDGVTTKTFCGTPWAFGVLLYEM--EGEDEDELFQSIME-ICKGLMTKHPGKRLGCGPEGERDIKEHAFFRYIDWEKLERKEIQPYKPKANFDRFFTRHPPVLTPPDQEVIRNI......................................................................................................................................................................................................................................................... 651
6 -7.550[IE] KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit  ali follow..  12  38..................................................................................................................................TTVGIDYNEPKFDKILIANRGEIACRVIK-TARAMGIKTVADSNSLHVKMADEAVCVGEAPTAKSYLRADRIPGYGFLSENTKFAAELEKAGAKF-----IGPNS-MIPADEDMCVKVSRDIGYPVMIKASAGGGGKGMRVAWNDKQAREDDRMLVEKFIDNPRHIE-----------------MQVLCDKHG-------------------NALWLRECSIQRRNQKVIEEA----------------------PSSFVPPEMRRKMGEQAVQLAKAVG----------------YDSAGVEFLVDSQRNFYFLEMN--TRLQVEHPITECITGDIVQQMLRVSGHPLPITQEQVPLNGWAFESRVYAEDPYK........................................................................................................................................................................................................................ 393
7 -7.520[M] COG1181 D-alanine-D-alanine ligase and related ATP-grasp enzymes  ali follow..  14  15....................................................................................................................................................EVSLSSGKGIMEALKANGHEVIGIDFHPDQVRDLVDLDVDLV-KVQALLDLLNIPYVGTGVQGSALAMDKAKAKLFFEKAGIRVAEEVVLHSFTYDANAFNFTGTYPVVVKPNQEGSTIGLTVAETEEELLQDDTILIEEFIAGTEVVLGNKGEERSLPVVEIVPKNKLYDYE--------SKYAPGMSE-------HIVPARIS----------------------------------EEHTAYVQQAAVRAHQAL-------------------GCDVYSRVDFIVPND-DPVILKVNTLPGMTPTSLYPDAAKEEMIQTFVNLS..................................................................................................................................................................................................................................................... 302
8 -7.130[T] KOG0694 Serine/threonine protein kinase  ali follow..  14  406..................................................................................................................................................................................................................................DEFNFIK-SF------KVMLAELKGKDEVYAVK-------KDVILQDDDVDCTMTEKRILALARKHPYLTQ-FQTKDRLFFVMEYVNDLMFQIFDEPRSRFYAAEYRDLKLDNIAEGHCKLADFGMCKEGILNGVTTTTFCGTPWALGVLMYEM--EADNEDDLFESILH-ILKAFMTKNPHLGCVASQNGEDAIKQHPFFKEIDWVLLEQKKIKPFKPRINFDQDFTREEPVLTLVDEAIVKQI......................................................................................................................................................................................................................................................... 720
9 -7.110[K] KOG3562 Forkhead/HNF-3-related transcription factor  ali follow..  22  1.............................................................................................................................................................................................................................................MPRPGRNTYSD---------QKPPYS-----ISLT----------AMAIQSSPEKMLPLSE------IYKFIMD--------------RF---PYYRENTQRWQNSLRH--NLSFND----FIKPDQPGKGSFWALHPSCGDMFENG................................................................................................................................................................................................................................................................................................................................................ 100
10 -7.010[R] COG2232 Predicted ATP-dependent carboligase related to biotin carboxylase  ali follow..  16  104....................................................................................................................................................................................................................DHVEDKYRLYRRIRNSYP-TPETHLI-SDPAEAMEIVAAGEKKYIAKPVSGAGGFGVTEFRE-----GDGEFLLQEY------IEGVPVSASVLSTGEDAITVLT-----------SRQIIDRGVPGFEGQFVYAGNMT------------------------------------PGPSGEIEDLASDLILD----------------------LSLRGVDLIMRDS-ELYVIEVN--PRIQGTFEAEASLGINMVDAHIRAC..................................................................................................................................................................................................................................................... 285
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Jaroszewski L, Godzik A. Sequence clustering strategies improve remote homology recognitions while reducing search times. Protein Eng. 2002 Aug;15(8):643-9.