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Query: [LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MPTNAGTSLSSYKHIVAIGTTVKSESLESAAYEIPRKRKMRSDSAAVSGNSVSTPKKLKSHLPSSVPNPGMSEKEVVEDSNEILRYPVNLAVSDCLGTKSKWSPRDEEQMRAVKEALHVSKAPSTILCREDEQIRIFEFVKGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSTQAGLPPVDTLSVNCTSLSKTTDIFSKILGEIKPGKNANTNSSPLQHLQNLFSQKQESSSSRMMLIIADEMDYLITKDRGVLYDLFMLTTLPFSRCILIGVANAIDLADRFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRVLSYVAFQPKALELCARKVAAASGDMRKALCVCRSALEILEIETRGSTGPESQGPTPDDSVVRMDHMAAALSKTFKSPVVETIQSLPQHQQIIICAAAKAFRGSKKDATVGELNKLYLEICKSWMISPAGITEFTNMCTVLNDQGILKVGQARRDKLKRVSLRVDESDITFALQVNSLFILFFANPLast
1 -114.000[LD] KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase  ali  100  1MPTNAGTSLSSYKHIVAIGTTVKSESLESAAYEIPRKRKMRSDSAAVSGNSVSTPKKLKSHLPSSVPNPGMSEKEVVEDSNEILRYPVNLAVSDCLGTKSKWSPRDEEQMRAVKEALHVSKAPSTILCREDEQIRIFEFVKGCIDQQKAGSLYICGCPGTGKSLSMEKVVQQVGDWSTQAGLPPVDTLSVNCTSLSKTTDIFSKILGEIKPGKNANTNSSPLQHLQNLFSQKQESSSSRMMLIIADEMDYLITKDRGVLYDLFMLTTLPFSRCILIGVANAIDLADRFLPKLKSLNCKPMVITFRAYSKDQILRILQERLRVLSYVAFQPKALELCARKVAAASGDMRKALCVCRSALEILEIETRGSTGPESQGPTPDDSVVRMDHMAAALSKTFKSPVVETIQSLPQHQQIIICAAAKAFRGSKKDATVGELNKLYLEICKSWMISPAGITEFTNMCTVLNDQGILKVGQARRDKLKRVSLRVDESDITFALQVNSLFILFFANP 507
2 -78.500[LO] COG1474 Cdc6-related protein, AAA superfamily ATPase  ali follow..  21  2.....................................................................................RRGSFMIKAQSLDGLFEKLLDGKSIFKNKEVLRPSYTPDLLLHRNEQINSLATILVSALRGETPSNVLIYGKTGTGKTAVTRYVGKELERVSEDKSL-FCSVVYINCEVIDTQYRLLANLARHFEEEV--PMTGWPTDQVFMKFKEAI-DARDQVIIIILDEIDKLIKKGDDVLYNLSRINTLRKAKVSMIGVSNDLKFTEFLDPRVKSS-LGEEELIFPPYDAEQISDILKQRAKAYNDGVLGEMVIPLCAAFAAQEHGDARRALDLLRVSGEIAERENQPQ--------------VLEEHVRRAQEKIEIDRVVEVVRTLPTQSKLVLYSIILLRSREGKNVTTGEMYNVYRQLCHHIDVDILTQRRVTDLMSELDMLGIVNASKGRYGRTKEISLSVPVENTRKVLLEDYRLKPLVDF. 410
3 -75.100[L] KOG1514 Origin recognition complex, subunit 1, and related proteins  ali follow..  19  272.PKEFSKASNDGDDVFLCEYEYDVHWGSFKRVAELADGDEDSDQEWNGRKEEEIDYSDEEIEFDDEESVRGVSKSKRGGANSRKGRFFGLEKVGMKRIPEHVRCHKQSELEKAKATLLLATRPKSLPCRSKEMEEITAFIKGSISDDQGRCMYIHGVPGTGKTISVLSVMKNLKAEVEAGSVSPYCFVEINGLKLASPENIYSVIYEGLSGHRVGWKKALQSLNERFAEGKKIGKENEKPCILLIDELDVLVTRNQSVLYNILDWPTKPNSKLVVLGIANTMDLPEKLLPRISS-RMGIQRLCFGPYNHRQLQEIISTRLEGI--NAFEKTAIEFASRKVAAISGDARRALEICRRAAEVADYRLKKS------NISAKSQLVIMADVEVAIQEMFQAPHIQVMKSVSKLSRIFLTAMVHELYKGMAETSFDRVATTVSSICLTNGEAFPGWDILLKIGCDLGECRIVLCEPGEKHRLQKLQLNFPSDDVAFALKDNKDLPWLAN.. 769
4 -41.900[L] KOG2228 Origin recognition complex, subunit 4  ali follow..  13  428.RGRPPKKRQENAEIRNITPGLTDSSVHSSSATPQSESSSPNSVSPLLPSSDRLPLLRQSQFTPPPKKPNFEVAIISPKKSQHKLYPNPVVESVFNDVPYSEIDSQLHTIKSTIAARLCGKSHIPLVGHMDEQTKLYQWVRQTIVLGEGNSVIIVGPRGSGKSVLVDDILSRAAQEINE----KSYVVRLNGTYQTDDKLALREISRQLSIELESIESDEALKSEMNF-IAEDVMTTSAAVIFVLEEFDLFVQSRQMLLYNLFDIAQSRKAPILIIGLTTRYDCSESLEKRVKSRFSHMVIPMRPPSSLSEFEQILKSVLY-VSDEGGKDQIITCWNQRVDELLSDTRSHLHKLVQHHYFASRNLKLVDLLFPILSMAPDRPLLADEDFANISLKVSDHKVELVKNLSLLELALLICAVRFEARDIPACNFNSAYQEYRQLHQSSVINAAASGAALEAWETLGSIGLIIPVHPSTNQCQLWQPEVDINVVSVGLREHRRLPSHYYR. 966
5 -28.600[L] KOG2543 Origin recognition complex, subunit 5  ali follow..  11  2................................................................................................................................ENCEIRRLKMLLFN--NSRIISHVHIFGEDGSGRSEIVRQLLRKPEN-------DWVCVLGDFLYADGSLKLLFDSLASSLGFKTRGDRAENFCDNLYKYVQWP--DETNRKIVIFLDNAQAITDYPPVPLQCLFDSYKA--QEITIRFVTSAPSCLNQYHINL--SHLPVVEFHIPAPSVETTKVLISRANPK-----INAQFLHVACQSLFMACKSPNILLSIISDAWLMYDERRTGDKFDSTLAKENENSFDAMPLAMRYLKILNRKYVVLPEIPVNFYFRYLLIAAYCASNNGPKAADLQRIICIYETLLKINE-STITGFDLKSVIASLDSMGLVSVTNRSNLDIPKIKCLISLESALKISRSLNLLRNYLEH. 416
6 -19.400[L] KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  10  10.......................SSDLAAEALTATGGDSIQKATDWILSHRSSPQSTATLQPKLDRFLRLHPKALAPAMGDDSSKRPNPKTQIHVAADDSNKRHKLSSSSHRQHQPLSERMRPRTL---QDHLLSPSSLLRSAVESNRLPSIVFWGPPGTGKTSIAKSLINSSKDPSLYR--------FVSLSAVTSGVKDVRDAVESA---------------------KRLNLEGRKRTVLFMDEVHRFNKSQQDTF-----LPVIEDGSILFIGATTEFHLITPLLSRC-------RVLTLNPLKPNHVETLLRRAVDDSERGLVDDSVIEFLANNC---DGDARVALNALEISATMATTRAGTDAVVSIDDAKEALQCKHLAYISALHKSMRGGDANAAIYWL---ARMLLYIARRLIRFASEDIGLADPSALTQAVACYQASHFLGMPECNVILAQC----TAYLALAPKSIAVYRAIGAAQKVVKDSVGQNEGVPLHLRN. 467
7 -18.700[L] COG0470 ATPase involved in DNA replication  ali follow..  15  1.............................................................................................................MSTSTEKRSKENLPWVEKYRPETLDEVITTVRKFVDEGKLPHLLFYGPPGTGKTSTIVALAREIYGKNYSNMV-----LELNASDDRGIDVV---------------------RNQIKDFASTRQIFSKGFKLIILDEADAMTNAAQNALRRVIE---RYTKNTRFCVLANY---AHKLTPALLSR----TRFRFQPLPQEAIERRIA-NVLVHEKLKLSPNAEKALIELS---NGDMRRVLNVLQSCKATLDNPDEDE--------------ISDDVIYECCGAPRPSDLKAVLKSILEDDWGTAHYTLNKVRSAKGLALIDLIEGIVKILEDYELQNEETRVHLLTKLADIEYSIS-------KGGNDQIQGSAVIGAIKASFENETVKANV.... 340
8 -18.500[DL] KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component  ali follow..  12  2...........................SKTFLRPKVSSTKVTDWVDPSFDDFLECSGVSTITATSLGVNNSSHRRKNGPSTLESSRFPARKRGNLSSLEQIYGLENSKEYLSENEPWVDKYKPHELAVHKKKIEEVETWLKAQVLERQPKQLLITGPPGCGKTTTLKILSKEHGIQVQEWINP--VLPDFQKDDFKGMFNTESSFHMFPYQSQIAVKEFLLRATKYNKLQMLGDDLRTDKKIILVEDLPNQFYRDSHTLHEVLR-KYVRIGRCPLIFIISDSLSGDLLFPKEIQEECSISNISFNPVAPTIMMKFLNRIVTGGKITVPDKTSLELL---CQGCSGDIRSAINSLQKGENNLRPRKKGMSLKSDAVLSKSKRRKKPDRVFENQEVQAIGGKDVSLFLFRALGKILLPSHLSEYERDTLLVEPEELHQNYIDFFM-------EIDDIVRASEFLSFADILSGDWNTRSLLREYSTSIATRGVMHS.............. 505
9 -18.100[S] COG4916 Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain  ali follow..  13  5..............................................................................................................KTLGDVFKTVGLPPYTYVKPKHFGEVRADISQ-----VGKHLLIEGPSGIGKTCVVFKVFEELQWSQGRD-------FTYVGCRDQNAEQIIDDFLKNAAAGNALSPC-----------------------VLVIDDFHLLSQAKRMEIGSTLK-EQAEPAKVILIGIPTAGVSLLSDAYDLGPR----GSYALTRASDVEIDKLISEGEQALAVLFEDRDVL------LAESAGNFWLAQYVCNKVCAIEEVYETQDDAKILTFDILGIRGRLMAELTQRYLPIART-FAKGKRWRPGGNKPYLEILLALCKIQDSVVTFDQLLQLVSE................................................................... 295
10 -17.800[L] KOG0991 Replication factor C, subunit RFC2  ali follow..  15  10........................................................................................AGEVEAQDSDPAPAFSKAPGSAGHYELPWVEKYRPVKL----NEIEDTVSRLEVFAREGNVPNIIIAGPPGTGKTTSILCLARALLGPALKDAM-----LELNASNDRGIDVV--------------------RNKIKMFAQQKVTLPKGRHKIIILDEADSMTDGAQQALRRTME---IYSKTTRFALACNA---SDKIIEPIQSR----AVLRYTKLTDAQILTRLM-NVIEKERVPYTDDGLEAIIFTA---QGDMRQALNNLQSTFSGFGF-------------------INSENVFKVCDEPHPLLVKEMIQHCVNANDEAYKILAHLWHLG---YSPEDIIGNIFRVCKTFQMAEYLKLEFIKEIGYTH............................................ 324
11 -17.800[L] KOG0990 Replication factor C, subunit RFC5  ali follow..  14  1............................................................................MTELTSAMDIDVDEIQPRKPINKGKDVVGFGPPPQSKATPWVEKYRPQSL----DDVRDIIDTIDRLTNENKLPHLLLYGPPGTGKTSTILAVARKLYGPKYRNMI-----LELNASD-DRGIDVVRQQIQDFASTQSFSLGKSSVK------------------LVLLDEADAMTKDAQFALRRVIE---KYTKSTRFALIGNH---VNKIIPALQSR----TRFRFAPLDGVHMSQRLK-HVIEAERLVVSDCGLAALVRLS---NGDMRKALNILQSTHMASKE------------TEEESKQITEEDVYLCTGNPLPKDIEQISHWL.................................................................................................... 282
12 -17.600[R] COG2607 Predicted ATPase (AAA+ superfamily)  ali follow..  11  58...........................................................................................................................VRLAGVGRQTELLVRNTEQFIVGRPANNVLMSGARGTGKSSLVKALLHEYAD-------KGLRLIEVDKSDLIGLPYLLTLL-----------------------------KECPEKFIVFCDDLSFESGDETKALKTALD--SQRCANVLVYATSNEIHQKEAVEEKISLSDRFGLWLSFYPFDQNDYLAAVQNWLEDFGVPY--DETAQMAALQWAQTRGSGRSAWQFACDWAGRLPKQRA............................................................................................................................................. 286
13 -17.500[L] COG2255 Holliday junction resolvasome, helicase subunit  ali follow..  15  9..........................................................................................................SAAVINDEESIDRAIRPKLLVGQPHVREQMEIFIQAAKRGDALDHVLIFGPPGLGKTTLANIIANEM----------GVNLRTTSGPVLEKAGDLAAMLTN------------------------------EPHDVLFIDEIHRLSPVVEEILYPAME--KLDLPPFTLIGATTR-SLTSPLRDRFGI------VQRLEFYQVADLEHIVSRSAKCLGLE-LTPEGAHQLARRS---RGTPRITNRLLRRVRDFAEVRADGAINGEVAMKALDMLNV............................................................................................................................ 256
14 -17.200[DL] KOG2035 Replication factor C, subunit RFC3  ali follow..  11  1.................................................................................................................MALWVDKYRPKDLLGKDGVDYHIEQANHKFLSADCMPHLLFCGPSGAGKKTRIKCLLRELYGVGVEKTQLIMKSFTSPSNKKLEIQTVSSNYHIEMTPSDVGIYDRVVVQDLVKEMAQTSQTSQRSFKVVVLCEADSLTRDAQHGLRRTME---KYANNCKIVLSCESL---SRIIEPLQSR----IIINVPAPTDEDVTKVLR-KVIERESFLLPENVLQKIVEKS---EGNLRRAILMTEALRMENESGVAESVVIPVPEWEIYIQETARLILQKQSSDMLLKERLYELLSRCIPPTVIFKKLLEHLLPKCPPQIAREVVSEAAKFEHRLVLGQKAIFHLEGFVAAF............................................. 342
15 -15.700[L] COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase  ali follow..  17  12...............................................................................................................EDFRPLAARMRPQTV---QQHILGPGKPLRRALEAGHIHSMILWGPPGTGKTTLAEVAANYANA--------EVERVSAVTSGVKEIRAAIEKA--------------------------RENKLSGRRTILFVDEVHRFNKSQQDAF-----LPHIEDGTVTFIGATTEFELNNALLSRA-------RVYKLTSLNQQEILQALHQAIADTERGLFADNVLDRLAELV---NGDARMSLNYLELLYDMAREDDQGRK------------QIDLPLLAEVAGE-----KVSRFDNKGDIWYDLISAVHKSIRGSDPDAAL............................................................................ 276
16 -14.900[O] KOG0726 26S proteasome regulatory complex, ATPase RPT2  ali follow..  17  184...........................................................................................................................ADIGGLDTQIQEIKESVELPLTHKPPKGVILYGPPGTGKTLLAKAVANQT----------SATFLRVVGSELIQKY-------------------GDGPKLVRELFRV---AEEHAPSIVFIDEIDAVGTKRQRTMLELLNQLD-SRGDVKVIMATNRIETLD---PALIRPGRIDRKIEFPLPDEKTKRRIFTIHTSRM--TLAEDVNLSELIMAKDDLSGDIK---AICTEAGLMALRERRMK--------------VTNEDFKKSKESVLYRKKEGTPEGL.................................................................................................... 437
17 -14.900[O] KOG0741 AAA+-type ATPase  ali follow..  13  218...........................................................................................................................MGIGGLDKEFSDIFR-IVEQMGCIHVKGILLYGPPGCGKTLLARQIGKML----NAREPKVVNGPEILNKYVGESEANIRKLFADAEEE------------------QRRLGANSGLHIIIFDEIDAICKQRDTVVNQLLS---EQLNNILVIGMTNRPDLIDEALLR-------EVKMEIGLPDEKGRLQILHIHTARMRGHLSADVDIKELAVETKNFSGELE---GLVRAAQSTANRHIKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYAS-KTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMKKIFDDAYKSVVDDIERLALLVLLKKAPPQGRKLLITTSRKDVLQEMEMLNAFSTTIHVP 668
18 -14.700[O] KOG0733 Nuclear AAA ATPase (VCP subfamily)  ali follow..  13  492...........................................................................................................................NNIGALKSIRVELQMAIVQPIKRSAPTGVLLWGPPGCGKTLLAKAVANES----------KANFISIRGPELLNKYV------------------GESERAVRQVFLR---ARASSPCVIFFDELDAMVPRRDDVVNTLLTELDSDRSGVYVIAATNR---PDIIDPAMLRPGRLDKTLLVDLPDAHERVEILKTLTKQTPHEEVNLDVLGRDERCSNFSGADLA---ALVREAAVTALRSAVFADIASNEPEITQHSRVTNADFELAFKNIKPSVSDRDRQKYQRLAKRWSSAS......................................................................................... 774
19 -14.700[O] KOG0728 26S proteasome regulatory complex, ATPase RPT6  ali follow..  17  148...........................................................................................................................EMVGGLDKQIKEIKEVIELPVKHAQPKGVLLYGPPGTGKTLLARAVAHHT----------ECTFIRVSGSELVQKF-------------------GEGSRMVRELFVM---AREHAPSIIFMDEIDSIGSSRQRTMLELLNQLDEATKNIKVIMATNRIDILD---PALLRPGRIDRKIEFPPPNEEARLDILKIHSRKM--NLTRGINLRKIAELMPGASGEVK---GVCTEAGMYALRERRVH--------------VTQEDFEMAVAKVMQKDSEKNMSIKK................................................................................................... 402
20 -14.700[L] KOG1968 Replication factor C, subunit RFC1 (large subunit)  ali follow..  12  314.....................................................................THLPASGGTGAAAQAAQQKKEQEEKKILETVARMDDSNKKESQPSQIWTSKYAPTSICGNKGVVQKLQKWLQD--GLGLYKAVLLSGPPGIGKTTAAHLVAKLE----------GYDVLELNASDTRSKRLLDEQLFGVTDSQSLAGYFGTKANP---------VDMAKSRLVLIMDEIDGMSSGDRGGVGQLNM---IKKSMIPIICICN-----DRAHPKLRPLDRTTFDLRFRRPDANSMRSRIMS--------IAYREGLKLVDQLVQGTQSDMRQIINLL----STYKLSCSEMTPQNSQAVIKNSEKHIVMKPWDICSRYLHGGMFHPSSKSTINDKLELYEFSYLMVQENYLNTTPDRIRQEPPK----MSHLKHLELISSAANSFSDSDLVD...................................... 695
21 -14.700[U] COG3267 Type II secretory pathway, component ExeA (predicted ATPase)  ali follow..  13  9................................................................................................................DELPFSIVPNARYLYLSQRHQEAIVHLQAGL--GDGGGFAMLTGEVGTGKTTVARAILASLPGKTRAGMILNPTF---------SDLELLEAICDEFEVSYPKKATLKKLTQVLHEFLLAEHAQGIQ-VLLMIDEAQHLAPDVLEQLRLLTNL-ETESHKLLKVLLIGQPELQEKLRLPQLRQLAQRITGRYLPLNEEQTADYIRFRIEQANPELFNRKACQWIAE---QTHGIPRLINLVCDAALKQAYQAGEPT--------------LSLARIKLACQEV................................................................................................................ 265
22 -14.600[L] COG2812 DNA polymerase III, gamma/tau subunits  ali follow..  15  4..................................................................................................................QALYRVWRPQDVVGQEH----ITKTLQNALVQEKFSHAYLSGPRGTGKTSAAKIIAKAINCEQAPIAEP-------ACKGITSGSIV-----DVMEIDAASNNGVDEIRDIRDHV--KFAPSEVRYKVYIIDEVHMLTTGAFNALLKTLEEP--PSHAIFILATTEPHKIPLTIISR--------QRFDFKRISNDALVGRMK-EILTHEGIEAEDEALVLVARAA---EGGMRDSLSLLDQAISFADER------------------VTVEDVLAITGAVSHEVLTQVVESAQKGEAEALQLVNQLLANGKDLRFVEDLIYYYRDLM---------------LFKAAPEASQLLERAQINDSFKTLAGEINDASLFAAIE............ 331
23 -14.400[R] COG2842 Uncharacterized ATPase, putative transposase  ali follow..  13  73................................................................................................................................ETATSRQIFKTLEFA--QIANCLATVYGMSGVGKTKAIQEFAKSHAN----------VWLVTASPSRSSLSEILYEIALELGISDAPRRKGTLSRLIARKIKGTEG-------LLIVDEADHLPYEALEELRIMQE---EAGIGLVLVGVYTRMK--ARLWSRVAK------NTSIQKTKKADTQAVAQAW------GLETDEEALKVMQSITETGGGLRILTQTYACRNGSKRIWQVD............................................................................................................................................ 287
24 -14.200[O] KOG0727 26S proteasome regulatory complex, ATPase RPT3  ali follow..  15  155...........................................................................................................................NDIGGCDIQKQEIREAVELPLTHDPPRGVLLYGPPGTGKTMLAKAVANHT----------TAAFIRVVGSEFVQKY-------------------GEGPRMVRDVFRL---AKENAPAIIFIDEVDAIATARQRILMELLNQMDDQTVNVKVIMATNRADTLD---PALLRPGRLDRKIEFPLPDRRQKRLVFQVCTSKM--NLSDEVDLEDYVSRPDKISAEIAA---ICQEAGMHAVRKNRYV--------------ILPKDFEKGYRANVKKPDTDF........................................................................................................ 404
25 -14.200[O] COG1222 ATP-dependent 26S proteasome regulatory subunit  ali follow..  15  148...........................................................................................................................EDIGGLERQIEELNEAIVLSLTHPEPKGVLMYGPPGTGKTLMARACASKT----------NATFLKLAGPQLVQMY-------------------GDGARLVRDAFAL---AKERKPTIIFIDEIDAIGAKRQRTMLELLNQLDSSSEEVKIIAATNRVDILD---PALLRSGRLDRKIEFPLPNTLGRKRILQIHARKM--SVRDDVNFDELARSTEGFNGQCK---AVCVEAGMAALRKEKTE--------------ISQNDFMDGIQEVLSRKKSKLL....................................................................................................... 398
26 -14.000[R] KOG2170 ATPase of the AAA+ superfamily  ali follow..  12  71.......................................................................................................................ADIANLLFGQHLVKDVVVNSIKSHWYNRKPLVLSFHGYTGSGKNYVAEIIANNTFRLGLRSTFVQHIVATNDFPDKNKLEEYQVELRNRILTTVQKCQRS----------------------IFIFDEADKLPEQLLGAIKPFLDYYSTISGRSIFILLSNGGEIARITKEQYESGYPREQLVPFLPLQREHVRSCVGAYLRKRGRGDLNVDFVERVLNSLQSSSG--------CKRVDAKTDLEMAKIRPLLSSVHFDDE............................................................................................................................... 355
27 -13.900[O] KOG0737 AAA+-type ATPase  ali follow..  13  414...........................................................................................................................ADIGSLDETKESLQELVMLPLRRKPCRGILLFGPPGTGKTMMAKAIANEA----------GASFINVSMSTITSDEKNVRALFT--------------------------LAAKVSPTIIFVDEVDSMLGQRTEFMTHWDGLMSNAGDRILVLAATNR-DLDEAIIRRF------ERRIMVGLPSVESREKILRTLLS---KEKTENLDFQELAQMTDGYSGDLK---NFCTTAAELIKQECLKDQERRKREEAEKNSELSMEDMKVAKSQVAASFAAEGAGMNELKQ................................................................................................ 706
28 -13.800[O] KOG0652 26S proteasome regulatory complex, ATPase RPT5  ali follow..  17  171...........................................................................................................................NDIGGLEKQIQELVEAIVLPMTHRPPKGVLLYGPPGTGKTLMARACAAQT----------NATFLKLAGPQLVQMF-------------------GDGAKLVRDAFQL---AKEKAPCIIFIDEIDAIGTKRQRTMLELLNQLDSSDERIKVIAATNRADILD---PALMRSGRLDRKIEFPHPTEEARARILQIHSRKM--NVHPDVNFEELARSTDDFNGQLK---AVCVEAGMLALRRDATE--------------VNHEDFNEGIIQVQAKKKASL........................................................................................................ 420
29 -13.600[O] KOG0651 26S proteasome regulatory complex, ATPase RPT4  ali follow..  16  150...........................................................................................................................SDVGGLAEQIRELREVVELPLINTPPKGCLLFGPPGTGKTLLARAVASQL----------DCNFLKVVSSAIVDKY-------------------GESARMIREMFNY---ARDHQPCIVFMDEIDAIGGRRQRTLMELLNQLDDSLGKVKVIMATNRPDTLD---PALLRPGRLDRKIEIGLPNEQSRLEILKIHSNKI--TKHGEIDFEAVVKLSDGFSADLR---NVCTEAGMFAIRAEREF--------------VIDEDFMKAVRKVGDAKRLETKLDYK................................................................................................... 404
30 -13.600[O] KOG0730 AAA+-type ATPase  ali follow..  15  240...........................................................................................................................DDVGGVRKQMAQIRELVELPLRHKPPKGILLYGPPGSGKTLIARAVANET----------GAFFFCINGPEIMSKL-------------------GESESNLRKAFEE---AEKNAPSIIFIDEIDSIAPKREKIVSQLLTLMDKSRAHVIVMGATNR---PNSIDPALRRFGRFDREIDIGVPDEIGRLEVLRIHTKNM--KLAEDVDLERISKDTHGYVGDLAA---LCTEAALQCIREKMDVIDLEDDSIDANSMAVSNEHFHTALGNSNPSALRETVVEVP----------------NVSWEDIGGLENVKRELQETVQY-PVEHPEKFEKFGMSPSKGVLFYGPPGCGKTLLAKISVKGPELLTMWESEANVREIFDK. 601
31 -13.400[O] KOG0729 26S proteasome regulatory complex, ATPase RPT1  ali follow..  17  175...........................................................................................................................SDVGGCKEQIEKLREVVETPLLHEPPKGVLLFGPPGTGKTLCARAVANRT----------DACFIRVIGSELVQKY---ARMVREL-----------------------EMARTKKACLIFFDEIDAIGGARQRTMLELIN----PRGNIKVLMATNRPDTLD---PALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSM--SVERDIRFELLARLCPNSTGEIRS---VCTEAGMFAIRARRKI--------------ATEKDFLEAVNKVIKSYAKFS........................................................................................................ 424
32 -13.200[O] COG0464 ATPases of the AAA+ class  ali follow..  15  216...........................................................................................................................EDLGGLKDAISKVREMIELPLKHDAPKGVLLQGPPGTGKTMLAKAVANES----------DAYFISINGPEIMSKY-------------------GESERAIREIFED---AEKNAPAIIFLDEIDSIAPKRAEVVAQLLS---KARKNVIVIGATNR---PEALDIALRRPGRFDREIELRVPDTEGRLEIFQIHTRGM--PLADNVNLMDFAQITYGFVGDIAA---LCREAAMSALRRILPKINLNEPEISKEILQVTREDFENALKDVQPSAIREILIEVP----------------NVSWEDVGGLERVKELLKEVVEW-PLKNPESYRDIGVEAPKGVLLYGPPGTGKTLLAKITAKGSDLLSKWESEKRIAEVFTR. 577
33 -13.000[R] COG1223 Predicted ATPase (AAA+ superfamily)  ali follow..  15  114.................................................................................................................................KRKAKVILEYLREKFGKWAPKNVLFYGPPGTGKTMMAKALSNEAKTPFLSVKSTKLIGEHVG-DGARRVHELYER------------------------------ARQLAPCIVFLDEFDAIALDRSEIVNALL----NSNEGICTIAATNRVELLDASIRSR------EEEIEFRLPSYEERLEILRRNLEEF--PVPVKARLELVAAASEGFSGDLVEKVI--KASLHKAIAEGKDK--------------IETEDLLTAAEKVKMPSRQPP........................................................................................................ 347
34 -12.900[F] COG1618 Predicted nucleotide kinase  ali follow..  11  1...........................................................................................................................................MRIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPKEGHREGFSIRDLATGK--------TGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIGPMELISQSFVSAVEEVLESDKPVLAVLHHSSRHPLAQRFRKGF-------EVLTVDKGNRDELPEKITNRFLR......................................................................................................................................................................................... 181
35 -12.700[R] COG1672 Predicted ATPase (AAA+ superfamily)  ali follow..  12  2.............................................................................................................................FLDRERELQFL----ERRYEMGGPEFIVIYGRRRVGKTALLLEFISR-------------GGIYLLARETSNLENL-KRFSDRLSEYFGDDFLKRNPFQNWDAFLEYLNQKATERLVVVIDEFPYLVKGDRSLPSILQEYLKLSNGRIFLIICGSSISMMEKLLGYKSP---RTGQINLKPVDFLHAREFLPGY---------LEDFIKAYG-----ILGGSPAHLLEFDDSKTIKE---------------------NLLEYLRSDSLLYQDAFFVLREEL--EEPRNYFAIMEAVAAGKTSLG------------EIMNETGLSRATVAKYLSVLIELDFVKITASRKSRRGRYYIK....................... 302
36 -12.100[R] COG4928 Predicted P-loop ATPase  ali follow..  10  24......................................................................................................................LSDPKDDKLGYAPFAKNLAESICK-MSPPDGLVIAVYAPWGLGKSTLLNFIIHYLKQKPEQE---QPIIVPYNPWWFSGQEDLTKSFFEQLSGVLYEKWQSKDIHKLKQEIEETLKKQQKR-ILVVIDDIDRLTAEEIRQLFRVIKAVANFPNVVYLLLVIKALEEIQKINGEVYLEKIVQVSFELPLPDRIQLSRLFDSQLDKIISGT--LEIYWQGIEHFITTPRSILRLANTLMVTYPGVKGE............................................................................................................................................... 314
37 -12.100[H] COG1239 Mg-chelatase subunit ChlI  ali follow..  14  56...........................................................................................................................PGVVGYDD---TVIPQLVNALLAR--QNFILLGLRGQAKSRILRAITELL-----DPEVPVIDGVDMPDDPLNTPDVTVADLIGDVDPIKAARLGTSLGDTRSMHFGLLPRANRG---IFAVNELADLSPKVQVALFNILQEGDVQELDVMLVFSANPEDYTAR-IVTPLKDRIGSEIRTHYPTDVQLGMDITAQEAVKEEGVVVPPFIAELIEDIAFQAR-SQRLPISLMELACANAERRSTGKMELEYEGELKGADNVAKDLIRKAAGAAYAR............................................................................................................. 390
38 -11.600[KT] COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  12  197........................................................................................................LRHNTHDATRNALRTRYVLGDMLGQSPQMEQVRQTILLYARSSA--AVLIEGETGTGKELAAQAI-EYFARHDARQGKKSHPFVAVNCGAIAES------LEAELFGYEEGAFTGSRRGGRAGLFEIAHGGT------LFLDEIGEMPLPLQTRLLRVLEEKEVTPVDVRVISATHC-NLEEDMRQGQFRRRLSILRLQLPPLRVADILPLAESFLKVSLAALGLQASETVLVH-----PGNIRELRNMMERLALFLSVEFLQLLLPELARESAKIPAPRLLTPQQALEKFNGDKTAAAISRTTFWRRL.............................................................................................. 526
39 -11.500[L] COG0593 ATPase involved in DNA replication initiation  ali follow..  10  132...................................................................................................................................KSNQLARAVGQKLAQAPGEPFFLYGGTGLGKTHLLHAIGNGILADK-----PNARVLYIHANNFMQ------HMVKAVRDNK----------------MDQFKKFYRSLDALLVDDIQFFAEKEQEEFFHIFNSLFETGRQIILTSDRYPKEIEK-IEERLKSRFGWGLTTAIEPPDLETRVAILLKKAEEHNMN-LPEEVAFFIAQRLRTNVRELEGALNRVKAMQDFKGGDIDIDFVRDKDILALQERLVTIENIQKVVAEYYRIKVSDLKRSVTRPRQIAMALAKELTNRSLPEIAFDRDHTTVLNACREVPKFREQDNSIQEDWANLIRT.......................................... 451
40 -11.100[O] KOG0740 AAA+-type ATPase  ali follow..  14  299..KEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVPMLRP-------DIFTGLRGPPKG-----ILLFGPPGTGKTLIGKCIASQSGA----------TFFSISASSLTSKW---EKMVRAL-----------------------AVARCQQPAVIFIDEIDSLLSQKTEFLVQLDGATTSSEDRILVVGATN--EIDEAARRRL------VKRLYIPLPEASARKQIVINLMSK-EQCCLSEEEIEQIVQQSDAFSGDMT---QLCRGASLGPIRSLQTA--DIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELY.................................................................................................... 663
41 -11.000[QK] COG3284 Transcriptional activator of acetoin/glycerol metabolism  ali follow..  12  330...........................................................................................................................RRLGGDAPVIAALQAKAAKLARTRLP--ILIQGETGTGKEHLARAIHEGSGLEGP--------FVAINCAAIPEQ------IESELFGYLPGAFTGASAKGRKGLIEQADGG------TLFLDEIGDMPLALQSRLLRVLA-TAPRKVRIRIVSASHR-PLQTLVSQGAFRERLNAATLTLPALDRPDFDWVLEQLLKRHGDGELSPAALSALKA------GNIRELDNVIGVAAALAENGVDQLLANADTVGGNEASATLSLTLTACNWNISEAARRLGLDRSTVHRQIKRYRL......................................................................................... 622
42 -10.900[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  10  42.......................................................................................................................................IWLLSIRLFRRTKSNTVLLSGLSGSGKTVLFYQLRGSSHQGAVTSMEPNEGTFVLHNENNTKKGKVKPVHLIDVPGH----------SRLISKLEEYLPRAAAVVFVVDALEFLPNIRAASEYLYDILTNASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAISTADIANDFTLGIEGEFSHCHNKVTVAEASGLTGETDQVQEFIREHVK.................................................................................................................................................... 259
43 -10.800[O] KOG0739 AAA+-type ATPase  ali follow..  14  44.....................KYEAHSDKAKESIRAKCVQYLDRAEKLKDYLRSKEKHGKKPVKENQSEGKGSDSDSEGDNPEKKKLQEQLMGAVVMEKPNIRWNDVAGLEGAKEALKEAVIPIKFP-------HLFTGKRTPWRG-----ILLFGPPGTGKSYLAKAVATEANNST---------FFSVSSSDLMSKW---EKLVKNL-----------------------ELARQHKPSIIFIDEVDSLCGSKTEFLVQM-QGVGNNNDGTLVLGATNIPWVLDSAIRRRFEKRI------YIPLPEEAARAQMFRLHLGSTPHNLTDANIHELARKTEGYSGDIS---IIVRDSLSPGDPGAMEMTWMDVPGDKLLEPVVCMSDMLRSLATTRPTVNADDLLKV.................................................................................................... 426
44 -10.800[O] KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain  ali follow..  17  674...............................................................................................................RNASALGAPKVPDDVGGLEDVKTSILDTVQLPLLHRKRSGVLLYGPPGTGKTLLAKAVATECS---------------LNFLSVKGP-----ELINMYIGESE--------KNVRDIFEK---ARSARPCVIFFDELDSLAPARDRVVSQMLA--SDSSQDLFIIGASNRPDLIDPAL--LRPGRFDKLLYVGVNADASYRERVLKALTRKF--KLSEDVSLYSVAKKCPTFTGDMYA---LCADAWFQAAKRKVSKSDSGDMPTEEDDPVVEYVDFIKAMDQLSPSLSITELKKYEMLRDQF............................................................................................. 968
45 -10.800[KT] COG4650 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain  ali follow..  11  184...........................................................................................................................SGIATRNPHFNRMIEQIEK-VAIKSRAPILLNGPTGAGKSF----LARRILELKQARHQFSGAFVEVNCATLRGMSTLFGHVKGAFTGARESREGLLRSAN-----------------MLFLDEIGELGADEQAMLLKAIE-DRQVSSDFQLIAGTVR-DLRQLVAEGKFRERINLWTFTLPGLRQEDIEPNLDYEVERHASLTNTEARRAWLAFATSPQAGNFRELSASVTRMATFATSGRLRYNWQESRPSALTALLGAEAENIDLFDRMQLEHVIAICRQAKSLSAAGRQLFDVSRQGKASVNDADRLRKYLARF.................................................................. 518
46 -10.600[KE] COG3283 Transcriptional regulator of aromatic amino acids metabolism  ali follow..  13  204...........................................................................................................................SQIIAVSAKMKHVVEQARKL--AMLSAPLLITGDTGTGKDLFAYACHQASPRSAKP-------YLALNCASIPE-----DAVESELFGHAPEGKKGFFEQA-----------------SVLLDEIGEMSPRMQAKLLRFLN-DHEIHVDVRVICATQK-NLVELVQKGLFRERLNVLTLNLPPLRPQDIMPLTELFVARFADEQLSADLSTVLTR------GNVRQLKNAIYRALTQLEGYELRPQDILLPDYDAATVAVGEDAMEGSLDDITSRFERSVLTQL.................................................................................................... 476
47 -10.600[T] COG5635 Predicted NTPase (NACHT family)  ali follow..  9  50...................................................................................................................................................EIPCLVLLGEPGVGKTHELEKLQRFTEETICEY-------SKVLGLNLRTFTNLKEDLFRDKTFSDWLEGHYH--------------------LHLFLDSLDEGLLNVKSLAIGLVDKYRSHINRLHLRLTCRTLAFPSILEEALKAL--NFAIYELAPLRRIDVINAVEAE-DDFLKAINQRDIVPLAIKNTYRRHNSQQKRYESYLEGCKCEEVSKCRHALKETGNLDIDQRLIVAARIAAVTIFANRFAVWIDVEQGQVPAEDVPRQKLCFGYEESNGREFEITQEVIQEVLDTGLFSSRGLHRMQTYAEFFAAWYLTQRNIDLSKIKTLLYSSADSTPKL-ASMRDNVFQEIIKDP 421
48 -10.400[R] COG3903 Predicted ATPase  ali follow..  11  2...........................................................................................................................................VQEVLTNYR---VTLRGEGGVGKTRLAIQIAAASE------------LCFVDLAPIADPGMVSTTAAHALGLIDRPGSS---------TFDTLSHAIGNCHMLMVLDNCEHVLDACAELVVELLG----ACPELSILA------------------------------TSRESIGVTGEVTWVVPSLSPANEAIQLFTERARLVADNFDAVSEICRRAIELAAARLRSLSPNEIANSLDDRFRLLTGGARSTVQQTLRASMDWSYALLTDTERILFRRLAVFV---------GFDLTAASEVAAAGGDDFVERYSVLDQLTLLVDKSLVVAEESRGSTRYRL-LETVRQYALEKLNESEEIDGV.... 318
49 -10.300[KT] COG3604 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains  ali follow..  10  166.................................................................................................SELENQAKQTQLRLEELNQEAWSRDSVEIIGNSGPMLAMKADIDVVAPSQF--NILIHGETGVGKELVARTIHQRSNRKRQP-------LVYVNCAAIPEESELFGHVKGAFTGADRARMGKFALAD-----------------TLFLDEIGELPLSAQSKILRALQNHEIQTVDVRILAATNR-DLKKEVEAGRFRARLSVYPIYVPPLRKGDLSLLAGYFVEQARRKLLHGDVLSQLIQ------GNVRELEHVINRAALKAKARQRGRPV-----------TLKVEDLGELQGPRAAMVEPTAQDEPMLGEWIGELGLRDATDEFQRHLISETLTQADFNWAEAARRLQTDRANLTRLAKRLG----ITVSRSHSIERSR........................... 530
50 -10.300[T] COG2766 Putative Ser protein kinase  ali follow..  13  76...........................................................................................................................EEFYGMEDAIEQIVSYLKHAAQGLEEKKLYLLGPVGGGKSSLAERLKSLMQRVP----IYVLSANGERSPVNDHPLCLFAQILEKEYGIPRRYLGTIMSPWAAKRLHEFGGDITKFRVIMEFVEMFKAPIKVLHPLLTATQEGNYNPFNGIILAHSNESEWVTFRNNKNNEAFLDRVYIVKVPYRISEEIKIYEKLLNHSELA-CAPGTLETLSRFSILSRLKEPENSSIYSKMKDTDPKAKSYQEYRDYAGVDEGMNGLSTRFAFKILSRVFNFDHAEVAAN-VLEQQIEREQFPQEQAERYLEFLKGYLIPKYAEFIGKE.............................................................. 486
51 -10.100[F] COG2019 Archaeal adenylate kinase  ali follow..  11  3.......................................................................................................................................................SVITGVAGVGKTTVLDIVARES----------GIPVVNYG--------TLMFEVAKRRGLVENRDQIRKLSRETQVDLQKLAGEEIGKMENAIVDTHMSIKTPFGYLPGLPEWVLRSINASVFVIIEADPAIIKRRRDNDPTRAR--------DDEGVDSIREHQEMNRYFAAA----SIFSGATVKIVKNEEGKPEQAADEIVRVIK.................................................................................................................................................... 181
52 -9.960[O] COG1219 ATP-dependent protease Clp, ATPase subunit  ali follow..  14  73.......................................................................................................................TILDQYVIGQERAKKVLAVAVYNHYKR-GKSNILMIGPTGSGKTLLAETLARLL----------NVPFTIADATTLTEAGYVGEDVENIIQKLLQKCDYDVEKAQM----------------IVYIDEIDKISRKSQQALLKLIE--QVDTRNILFICGGAFAGLERVIQNRSARGGIGPVIATLDELDEAALMQILTEPKNALTKQYFRPDALKAVARKALERKTGARGLRSILEGILL.................................................................................................................................................... 381
53 -9.920[F] KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response  ali follow..  10  5......................................................................................................................................................NILLTGTPGVGKTTLGKELASKS----------GLKYINVG------------DLAREEQLYDGYDEEYDCPILDEDRVVDELDNQMREGGVIV----------------HGCDFFPERWFHIVFVLRTDTNVLYERLETRGYNEKKLTDNI------QCEIFQVLYEEATASYKEEI---VHQLPSNKPEELENNVDQILKWIEQWIK.................................................................................................................................................... 168
54 -9.920[KT] COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains  ali follow..  12  270...........................................................................................................................EQLVGECRVMRQLKRLISRI--APSPSSVMVVGESGTGKEVVARAIHKLSGRRNKP-------FIAINCAAIPEQ------LESELFGYVKGAFTGASANGKTGLIQAANTGT------LFLDEIGDMPLMLQAKLLRAIE-SSPIQVDIRIISATNQ-NLAQFIAEGKFRERLNVIPITLPPLRQEDIELLVHYFLHLHTRRLIAPDVVEILRK------GNLRELSNLMEYLVNVVPSGNNGTTEQSDVTEVTEAHLSLDDAGGTALEEMEKQMIREALSRHNSKKQVA-------DELGIGIATLYRKIKKY..................................................................... 587
55 -9.900[O] KOG0743 AAA+-type ATPase  ali follow..  10  202..............................................................................................................LEHPSTFDTLAMDPNA--KKKIIDDLERFLKRKEFYKRVGKAWLYGPPGTGKSSLIAAMANYL----------KFDVFDLELSSIYDNGEL-KRVLLSTTNRS----------------------------ILVIEDIDCNAEVRDR------QEDEQIKGKVTLSGILNFID-KERLDPALLRPGRMDVHINMSYCTGLGFRTLVSNPLCEEIEALVDSTEVT-----PAELAEDTDVVLRGVISFVEKRKVERSKTKKEVSICKATDDDEKQNGSLGCVKKKKKGGKQKGKGKARSKEIPQDNCGFRLTEMFPSISNISLSPSSLFTAYASLTGFLMLFRSLFNDEV................................................ 539
56 -9.870[R] COG3899 Predicted ATPase  ali follow..  11  1.............................................................................................................................LYGRETEVANLLAAFER-VANGASEMMLVAGFSGIGKTAVINEVHKPITRQQGYFIKGKFDQFNRN-IPFSAFVQALRDLMGQLLSESDTQSGMAAQNRFNLLFQKFLETTKERPLVMFLDDLQWADSASLNLIKLLME----DENYLLLLGADNEVSPVHPFVTELKKTDKTVNTITLAPLALSDTNQLVSDTLSQINALSLTDDVVEFMAHQLQKLPSETQQILKLAAVTLAIVSEQLQAQTAVALWKALQSGLILPQGEVYKFYLSDDQQNLNNTYRFLHDRVQQAAYSLIPDVQKQTTHLNIGTL------LLANLSVNERE-ERIFEIVNHLNIGSKLITQTSQKEELAKLNLLAGTRAKSSTAYSAAL........ 472
57 -9.800[O] COG0465 ATP-dependent Zn proteases  ali follow..  12  161.................................................................................................................................KEEVSELVDYLREKLGGKIPKGVLMVGPPGTGKTLLAKAIAGEAKVPFFTISGSDFVEMFVG-VGASRVRDMFEQ------------------------------AKKAAPCIIFIDEIDAV-DEREQTLNQML----EGNEGIIVIAATNRPDVLDPALLR-------DRQVVVGLPDVRGREQILKVHMRRV--PLDTDIDASVIARGTPGFSGDLA---NLVNEAALFAARGNKRV--------------VSMVEFEKAKDKIMMGAERRSMVMTEAQKESTAYAIIGRLVPEHDPVHKVTIIPRVTFFLPEGDAISASRQKLESQISTL------------GGRLAE-EIIYGPEKVSTGASND.......... 492
58 -9.790[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  9  7.......................................................................................................................................................IGVGGPVGAGKTMLIERLTRYLSTKGYS-----MAAITNDIYTKEDARILLNT--SVLPADRIAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDLQLLFLESGGDNLSATFSPDLVDFSIYIIDVAQGEKIPRKGGQGMIKSDL-----------------FIINKVDLAPYVGANVEVMKADTLKTNLKTDELKSVADWIEKRLQLALLE............................................................................................................................................... 205
59 -9.770[O] COG0542 ATPases with chaperone activity, ATP-binding subunit  ali follow..  13  177...........................................................................................................................DPVIGRDEEIRRAIQVLQ----RRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSLDMGALIAGAKYRGEFEERLKA--------------------NELSKEEGRVILFIDEIHTMVGAGKT---NLLK-PSLARGELHCVG-ATTLDEYRQYIEKDAALERRFQKVFVGEPTVEDTIAILRERYEIHHHVQITDPAIVAAATLSHRYVSDRQKAIDLIDEAASSIRMEIDSKPQPLDRLERRIIQLKLEQQALQKEDDDASRKRLAMLEKELGEKEREYAELEDVWKAEKAALSGTQHIKAELDSAKTQMEQARRASDFAKMSELALEKQLAQAESAEGKEMTLLRYRVTDEEIAEVLSR........... 541
60 -9.730[V] COG3896 Chloramphenicol 3-O-phosphotransferase  ali follow..  10  5..................................................................................................................................TRARRMRYRLAAMAGMPEGKLILLNGGSSAGKTSLALAFQDLAAECWMHIGIDLFWFAQLDLARVRPEYYTWDSAVEADGLEWFTVHPGPILDLAMHSRYRAIRAYLDNGMNVIADDVIWTREWLVDAL------RVFEGCRVWMVGVHVSDEEGARRELERGDRHPGWNRGSARAAHADAEYDFELDTTATPVHELARELHESYQACPYPMAFNRLRKRF............................................................................................................................................................ 223
61 -9.620[R] KOG2383 Predicted ATPase  ali follow..  11  99..................................................................................................................................QCLQKLHEDLKGY-RSKPPRGLYVYGDVGTGKTMVMDMFYAYVEMKRKKR-------VHFH--------GFMLDVHKRIHRQSLPKRKPGFMAKSYDPIAPIAEEISEEACLLCFDEFQVTDIADAMILKQLFE--NLFKNGVVVVATSNR---PEDLYKN------GLQRANFVPF-------------------------------------------IAVLKEYCNTVQLDSGIDYRKRELPAAGKLYYLTSEADVEAVMDKLFDELAQKQNDLTRPRILKVQGRELRLNKACGTV----ADCTFEELCE----RPLGASDYLELSKNFDTINIPQFTLANRTQGRRFITLIDDLKVRIICSASTPISSLFLH. 418
62 -9.610[J] KOG3928 Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3  ali follow..  10  11....................................SRIHKLDPGRFLHMGTQARQSIAAHLDNQVPVESPRAISRTNENDPAKHGDQHEGQHYNISPQDLETVFPHGLPPRFVMQVKTFSEACLMV-RKPALE-LLHYLKNTSFAYPAIRYLLYGEKGTGKTLSLCHVIHFCAKQTNERFLNQIKVQEKYVWNKRESTEKGSPLGEVVEQGITRVRNATDAVGIVLKELKRQSSLGMFHLLVAVDGINALWGRTTALVHNLRKMMKNDWHGGAIVSALSQTGSLELLGKEGFDALDPFIPILVSNYNPKEFESCIQYYLENNWLQHEKAPTEEGKKELLFLSNANPSLLERHCAY....................................................................................................................................................... 397
63 -9.610[R] COG1483 Predicted ATPase (AAA+ superfamily)  ali follow..  8  32........................................................................................................EAPEIYRDPKEFFKRTYFTDAT-------VEILKRILDTFEGKERRNIFIYSLFGGGKTHLLLTLYHAFKTPEALEDPESVKVVPVYGKGRVGQKTIWGYIAHSLGKYSIVEKNDKNLTVPDIETLRDLFKGER--VLLLIDEIRRYAGNVDNFIDRLSSALSNSTSSMVITLPMTEERVVRALWDAVRRGGADSYTPVRTVGINDELVEVLKKRIFKHVDPDFHPEYIQILRTIIEKTD-RTRDMIRITRIVVRNLIDRYEKEGFAPAIILPIHIDLTNDRIRGMLFGEKSKFADYASIIDAELVNDIFLRTYPFDAPTPLNDFPTLTTISRAIYDPETFSKKQWIPADIKDTVEEIESHPHF--------------VFLNRKDGVFWFWRVANVTKMVDS. 528
64 -9.570[T] KOG4658 Apoptotic ATPase  ali follow..  9  151...........................................................................................................................QPTIGQEDMLEKAWN----RLMEDGVGIMGLHGMGGVGKTTLFKKIHNKFAEIGGTFDI----VIWIVVSKGVMISKLQEDIAEKLHLCDDLWKNKNESDKATDIHRVLKGKR----FVLMLDDI------EKVDLEAIGIPYPSEVNKCKVAFTTRSREVCGEMGDH--------KPMQVNCLEPEDAWELFKNKVGD--NTLSSDPVIVELAREVAQKCRGLPLALNVIGETMSSKTMVQEWEHAIHVFNTSAAEFSDMQNKILPILKYSYDSLGDEHIKSC-----FLYCALF----PEDGEIYNEKLIDYWEGFIGEDQVIKRARNKGYAMLGTLTRANLLT-----KVGTYYCVMHDVVREMALWIASD.......... 485
65 -9.560[O] KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases  ali follow..  19  181...........................................................................................................................DPVIGREDEIRRTIRVLS----RRTKNNPVLIGEPGVGKTSIAEGLARRIIDDDVPANLSNCKLLSLDVGSLVAGSKFRGEFEERIKS--------------------KEVEESETPIILFVDEMHLLMGAGSG---NLLK-PMLARGKLHCIG-ATTLAEYKKYIEKDAAFERRFQIILVKEPSIEDTISILKEKYEVHHGVTISDRALVTAAHLASRYLTSRRSAIDLVDEAAAAVRVTRESQPEV........................................................................................................................................ 415
66 -9.540[K] KOG2680 DNA helicase TIP49, TBP-interacting protein  ali follow..  15  45.................................................................................................................................QVKARKAAGVILQMIREGKGRAILIAGQPGTGKTAIAMGMAKSLDRPASSGVASKSGKMTMKTTDMETVYDMGAKMIEALNKEKVQSGRSEVREQIDTKVAEWREEGKAEIVVLFIDEVHMLDIECFSFLNRALENEMSP----ILVVATNRIDLLDRLL-----------IITTQPYTDDDIRKILEIRCQE-EDVEMNEEAKQLLTL--IGRDTSLRYAIHLITAAALSCQKRKGKV--------------VEVEDIQRVYRLFLDVR--RSMQYLVEYQSQYMFSEPIKNDEAAAE............................................................................... 461
67 -9.400[R] COG5271 AAA ATPase containing von Willebrand factor type A (vWA) domain  ali follow..  9  136..................................................................................................................................KSTQENLNRITPYLVQKRP--ILLAGPEGIGKKFLITQIAAKLGQ----------QIIRIHLSDSTDPKMLIGTY---------TSPKPGEFEWQPGVLTQAVITGK-----ILFTNIEHAPSEVLSVLLPLLE-----KRQLVIIYAKGSFQMFATSSMKTKILGQRLWQILDLTYQPDECVEVVSTLYPVL--SIICPTLYSVYKDIFDLFS-CLRDFYKFIKRVAFLYHKFMIPSDHVVISQEL-EAIDMFGAFIPSRDGFDLVVRNVAIELNIPPEKALQLRYSIPVFQNLEHNINIGRCSLKKLSTIRSCSTNSYSLGLLEQLAAGVQNEPLLLVGETGTGKTTTIQLGLLGQKVTVIMSQQTESSDMLGG. 512
68 -9.390[R] COG1373 Predicted ATPase (AAA+ superfamily)  ali follow..  8  51.......................................................................................................................................................YTLRGPRQVGKTTLVKLIIRELLETIEHSQ----SIFYFTCDLVADEKELFEVL---------------------DLYLKWAAAFRLERKYIFLDEISSVRD--EKGLKYLVDTGALNNATVVLTG-SHSIDIKSSIERLPGRRGEGEGTLDKIPMKFSEYNGLFEAEKRQEILSNLSEGRADPLLNMLLLYQPELDRLFDQYLLTGGIPRAVNEFFSK---------------NKIDSSIYEIYIQSLIGDLARWNIPEMPVKQTLRSIAGKLTTPVSWRSITDE---------TDIGAHVTVRKYVTALEDSFVLDLPKKTANFKKEKKIYFQDPFIFHALHA........... 366
69 -9.370[S] KOG4308 LRR-containing protein  ali follow..  10  192.................................................................................................................................................NEQGETIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKHFRCRMFSCFKESDRLCLQDLLFKHYCYPERDPEEVFAFLL-----------RFPHVALFTFDGLDELHAHPLVLLANLLSGKLLKGASK-LLTARTGIEVPRQFLRKK---------VLLRGFSPSHLRAYARRMFPE-----------RALQDRLLSQLEANPNLCSLCSVPL-RAAFEGSPQLPDCTMTLTDVFLLVTEVHLNRMQPSSLVQRNTRSPVETLHAGRDTLCSLGQVAHRGMEKSLF............................................................................ 476
70 -9.370[L] COG0507 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member  ali follow..  14  39.................................................................................................................................APQQDEALKAVSQWLKGGRSQLFRLFGYAGTGKTTLARHFAENVDGEVVFAAFTGKAAQVLRSKGATNAKTIHSLIYRP-RGEEEVEDEETGKTSIAPMFAINRQSPVAKAALIIVDECSMV---DEALGKDLMSF----GTPILVLGDPGQLP-------------VSGGGYFTNHEPDFLLTDIHRQA---------RDNPIIQLAMQVRE..................................................................................................................................................................... 222
71 -9.160[A] KOG1804 RNA helicase  ali follow..  13  311................................................................................................................................NENQKLAVKRILSG---DCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRI-------LVCAPSNSAADLVCLMVRVNATCRFEEIVIDAVKPYCRDGEDIWKASRFRIIIVFVDEAGQ--ASEPECLIPLGLMSD-ISGQIVLAGLAMAYGLNVSFLERLMSRPAYQRD---GAHNPLLVTKLVKNRLLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPS-NPAEAVQVLRYCCLLAHSISSQVSASDIGVITPYRKQVEKIRILLRNVDLMDIKVGSV-EEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLS----------------NSKRFNVAITRPKALLIVLGNP 714
72 -9.160[O] KOG2004 Mitochondrial ATP-dependent protease PIM1/LON  ali follow..  15  463.......................................................................................................SPENRRLSVAKKALDEGH------GMKDVKERIMEFINLLRKSIGGKILCFHGPPGVGKTSIAKSIATALNREYFRFSVGGMT-AEIKGHRRTYVGAMPGKMIQCMKKVKTEN-------------------------LVLIDEVDKIGGAGASALLELLDPEQNANSRVLFICTANEISIPGPLRDRM-------EMIDVSGYLAEEKVEIAHQHL-ATEQLKIEDSALEELIKHYCRESGNLQQHIEIFRKALQIAEQQNEDEEPAEKATTAITENSEAEPITSTSSADCLKSSAEQIVVCTENLQKFV............................................................................................. 771
73 -9.160[O] KOG0731 AAA+-type ATPase containing the peptidase M41 domain  ali follow..  13  329.................................................................................................................................KQEIMEFVHFLKNDLGAKIPKGALLVGPPGTGKTLLAKATAGE----------SGVPFLSISGSD-------FMEMFVGVGPSRVRH----------------QEARQAAPSIIFIDEIDAI-DERESTLNQLL-----TTAGVVVLAGTNRPDILDKALLR-------DRQITIDKPDIKGRDQIFKIYLKKIKLDHEPSYYSQRLAALTPGFAGDIA---NVCNEAALIAARHEGAT--------------VTMAHFESAIDRVIGGLEKKNRVISKLERRTVALGFAQYVPNENLLMTKEQLFDMTCRAAEQVLIGKISTGAQNDLEKVTKMTYAQVAVYGFSDKVGLLSFPPRDDGYDFSKPYSNKTGAIIDE. 709
74 -9.120[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  13  1....................................................................................................................................MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKA--EKIQPTVGQNVATIPVDSKQILKFWD---------GGQESLRSMWSEYYSLCHG-----IIFIVDSSDR-LDECSTTLQSVVMDEEIEGVPILML--ANKQDRQDRM-------------------EVQDIKEVFNKIAEHISARDSR-------VLPISALTGEVKDAIEWMIVRLERNKKSRPPIYK......................................................................................................................................... 198
75 -9.110[L] COG5575 Origin recognition complex, subunit 2  ali follow..  10  101.DDNVGSNSLLDVPLYSLEAEPLSPSVMLEDESMEGINQSPQGISVEKLGKEDNRSRSSTPASPSLESHEFSESREAGLSQSNGFEARSHGTGFDEYFDKFSQRKTSSNTLSQLPVLDNQVYLDTVKEICTETEQHTQTLVHFQSRVNNFNLLFYG--GS-KEHFLSSFVEKK--------LPCFPIFVVKGYFPQQLKNVLSSFLEFLEVTPAASVSDMLIQSLSII---NSPSFSLGKIVFLVHNIDLIDERFQSALAAIASSK-----NVYFIASVDHVNFA--LWDTSLESSFN-DATTFARYYN-------------------------------------------------ETTYENSLGIGRANVSNKEKAIKHV--------------------LYSLPANSRGIFKFLLIHQLERMMDTQDFD-YRSFFQKCSAEFLCS-NEPNFRSQLTEFFDHNIIESKRDVSN-SEILWVPYPKNLLEILLED........... 530
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Jaroszewski L, Li W, Godzik A. Comparison of sequence profiles. Strategies for structural predictions using sequence information. Protein Sci. 2000 Feb;9(2):232-41.