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Query: [K] KOG2251 Homeobox transcription factor, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVLLast
1 -91.300[K] KOG2251 Homeobox transcription factor  ali  100  1MMSYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKKTSPAREVSSESGTSGQFTPPSSTSVPTIASSSAPVSIWSPASISPLSDPLSTSSSCMQRSYPMTYTQASGYSQGYAGSTSYFGGMDCGSYLTPMHHQLPGPGATLSPMGTNAVTSHLNQSPASLSTQGYGASSLGFNSTTDCLDYKDQTASWKLNFNADCLDYKDQTSSWKFQVL 297
2 -60.800[K] KOG0484 Transcription factor PHOX2/ARIX, contains HOX domain  ali follow..  28  70.........................YSAVPYNFFPEPSGLHEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAASAKGAAGAAGAKKGEARCSSEDDDSKESTCSPTPDSTASLPPPPAPGLASPRLSPSPLPVALGSGPGPGPGPQPLKGALWAGVAGGGGGGPGAGAAELLKAWQPAESGPGPFSGVLSSFHRKPGPALKTN........................................................... 282
3 -60.300[K] KOG0486 Transcription factor PTX1, contains HOX domain  ali follow..  41  64.................SPEAAEKDKSQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAE.......................................................................................................................................................................................... 157
4 -59.000[R] KOG0494 Transcription factor CHX10 and related HOX domain proteins  ali follow..  42  117..........................SNSSGGGSSGGGGKASKRKKRRHRTIFTQYQIDELEKAFQDSHYPDIYAREVLAGKTELQEDRIQVWFQNRRAKWRKTEKTWGKS.......................................................................................................................................................................................... 201
5 -53.200[K] COG5576 Homeodomain-containing transcription factor  ali follow..  17  147..........................KENVAHESGTPESGGSTSAPKSKKQRLTADQLAYLLREFSKDTNPPPAIREKIGRELNIPERSVTIWFQNRRAKSKLISRRQEEERQRILREQRELDSLNQKVSQAFAHEVLSTSPTSPYVGGIAANRQYANTLLPKPTRKTGNFYMKSGPMQSSMEPCIAESDIPIRQSLSSTYYNSLSPNAVPVSSQRKYSASSYSAIPNAMSVSNQAFDVESPPSSYATPLTGIRMPQPESDLYSYPREVSPSSGGYRMFGHSKPSSYKASLWKYRI. 483
6 -51.400[K] KOG0485 Transcription factor NKX-5.1/HMX1, contains HOX domain  ali follow..  21  91.................SCLDDNMDDGKSDIDLASDDGNGLGDDRKKRPRTAFSAAQIKALETEFERGKYLSVAKRTALAKQLQLTETQIKIWFQNRRTKWKRKYTSDVET.......................................................................................................................................................................................... 184
7 -47.700[K] KOG0850 Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains  ali follow..  17  110..........................SVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSASPSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY............................................................................................. 287
8 -45.700[K] KOG0843 Transcription factor EMX1 and related HOX domain proteins  ali follow..  29  319..........................................ERQQKRVRTMFNLEQLEELEKVFAKQHNLVGKKRAQLAARLKLTENQVRVWFQNRRVKYQKQQKLRAAVTSAEAASLDEPSSSSIASIQSDDAESG............................................................................................................................................................... 414
9 -45.300[K] KOG0844 Transcription factor EVX1, contains HOX domain  ali follow..  31  155.................GGSETPKSNGGSGGGGSQGTLACSASDQMRRYRTAFTREQIARLEKEFYRENYVSRPRRCELAAALNLPETTIKVWFQNRRMKDKRQRLAMTWP.......................................................................................................................................................................................... 248
10 -41.100[R] KOG0489 Transcription factor zerknullt and related HOX domain proteins  ali follow..  25  289...............SDDEGAQSRHEGGGMGGKDSQGNGSSSNSKSRRRRTAFTSEQLLELEREFHAKKYLSLTERSQIATSLKLSEVQVKIWFQNRRAKWKRVKAGLTSHGLGRNGTTS................................................................................................................................................................................. 393
11 -39.200[R] KOG0488 Transcription factor BarH and related HOX domain proteins  ali follow..  20  164...........................................PKRKKPRTSFSRVQICELEKRFHRQKYLASAERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLMLQLQHDAFQKSLNDSIQPDPLCLHNSSLFALQNLQPWEEDSSKVPAVTS................................................................................................................................ 289
12 -39.000[K] KOG0847 Transcription factor, contains HOX domain  ali follow..  31  168............................................QKKQSRPTFTGHQIYQLERKFEQTKYLAGADRAQLAQELNMSESQVKVWFQNRRTKWRKKEAADNALVKRGASGDKSPCSLSPFLSA...................................................................................................................................................................... 254
13 -39.000[R] KOG0492 Transcription factor MSH, contains HOX domain  ali follow..  30  128...............................HMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRSAKAKRLQEAELEKLKMAAKPM.................................................................................................................................................................................. 215
14 -38.000[K] KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain  ali follow..  22  100.................SSKSPEPSADESPDNDKETPGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSP................................................................................................................................................................................... 200
15 -37.600[K] KOG0483 Transcription factor HEX, contains HOX and HALZ domains  ali follow..  17  51...........................EDDGSLEDLGGVGHASSTAAEKKRRLGVEQVKALEKNFEIDNKLEPERKVKLAQELGLQPRQVAIWFQNRRARWKTKQLERDYGVLKSNFDA.................................................................................................................................................................................. 142
16 -37.300[K] KOG3802 Transcription factor OCT-1, contains POU and HOX domains  ali follow..  23  276...........................................GRKRKKRTSIEVSVKGVLETHFLKCPKPAAQEISSLADSLQLEKEVVRVWFCNRRQKEKRMTPPGDQQPHEVYSHTVKTDTSCHD......................................................................................................................................................................... 360
17 -37.200[K] KOG1168 Transcription factor ACJ6/BRN-3, contains POU and HOX domains  ali follow..  24  310..........................................AGEKKRKRTSIAAPEKRSLEAYFAVQPRPSGEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRIVSSVTPSMTGHGSAG.................................................................................................................................................................................. 386
18 -36.100[K] KOG0848 Transcription factor Caudal, contains HOX domain  ali follow..  23  184...........................................RTKDKYRVVYTDHQRLELEKEFHYSRY-----KAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVSGSVPGVLGPTGGVLNPTVT............................................................................................................................. 312
19 -34.800[K] KOG0487 Transcription factor Abd-B, contains HOX domain  ali follow..  35  183...........................................RSSRKKRCPYTKYQTLELEKEFLFNMY---LTRDEVARLLNLSERQVKIWFQNRRMKMKKMNKEQGKE.......................................................................................................................................................................................... 250
20 -33.000[R] KOG0493 Transcription factor Engrailed, contains HOX domain  ali follow..  20  453............................................DEKRPRTAFSSEQLARLKREFNENRY-----RQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQLMAQGLYNHTTVPLTKEEEELEMRMNGQIP......................................................................................................................................................... 552
21 -30.600[K] KOG2252 CCAAT displacement protein and related homeoproteins  ali follow..  21  366MYNWVAQPLA--TEDVNRASGMSPPTPAQNVRTHRRSTSDHDGPVSKRPRLVFTDIQKRTLQAIFKETQRPSREMQQTIAEHLRLDLSTVANFFMNARRRSRLGGNIDEPTPFQQVKNISPPPVGDTSDALLNGDD................................................................................................................................................................. 508
22 -20.500[R] KOG0491 Transcription factor BSH, contains HOX domain  ali follow..  27  382...........................................CRRRKARTVFSDSQLSGLEKRFEIQRYPE---RVELATALSLSETQVKTWFQNRRMKHKKQLRKSQDEPKAPDGPESPEGSPRGSEAATAAEARLSLPAGPFVLTEPED................................................................................................................................................. 490
23 -19.000[K] KOG0774 Transcription factor PBX and related HOX domain proteins  ali follow..  23  233...........................................LDARRKRRNFSKQATEILNEYFYS-HYPSEEAKEELAKKCSITVSQVSNWFGNKRIRKKNIGKFQEEANLYAAKTAVTAAHAVAAAVQNNQTNSPTTPNSGSSGSFNLPNS............................................................................................................................................... 347
24 -18.900[K] KOG0775 Transcription factor SIX and related HOX domain proteins  ali follow..  19  123............................................DGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQGNMGHARSSNYSLPGLTASQPSHGLQTHQHQLQDSLLGPLTSSLVDLGS........................................................................................... 284
25 -16.700[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  19  161..........................SSDKETANNENEEQNSGTKRRGPRTTIKAKQLETLKAAFAATPKPTRHIREQLAQETGLNMRVIQVWFQNRRSKERRMKQLSALGARRHAFFRSPRRMRPLGGRLDESEMLGSTP------------------------YTYYGDYQGDYYAPGSNYDFFAHGPPSQAQSPADSSFLAASGPGSTPLGALEPPLAGPHAADNPRFTDMISHPDTPSPEPGLPGTLHPMPGEVFSGGPSPPFPMSGTSGYSGPLSHPNPELNEAAVW..... 402
26 -16.200[K] KOG0773 Transcription factor MEIS1 and related HOX domain proteins  ali follow..  13  341..........................................EILRKRRAGKLPGDTTSVL-KAWWQSHYPTEEDKARLVQETGLQLKQINNWFINQRKRWHSNPSSSTVLKNKRKSNAGDNSG............................................................................................................................................................................. 426
27 -15.600[K] KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains  ali follow..  20  195.........................NRLDEGSDVESEPDLPLKRKQRRSRTTFTAEQLEELEKAFERTHYPDIYTREELAQRTKLTEARVQVWFSNRRARWRKQAGANQLAAFNHLLPGGFPPTGMPTLPPYQLPDSTYPTTTISQDGGSTVHRPQPLPPSTMHQGGLAAAAAAADTSSAYGARHSFSSYSDSFMNPAAPSNHMNPVSNGLSPQVMSILGNPSAVPPQPQADFSISPLHGGLDSATSISASCSQRADSIKPGDSLPTSQAYCPPTYSTTG................. 449
28 -14.300[K] KOG3862 Transcription factor PAX2/5/8, contains PAX domain  ali follow..  12  202..........................DQDSCRLSIDSQSSSSGPRKHLRTDAFSQHHLEPLECPFERQHYPEAYASPSHT---KGEQGLYPLPLLNSTLDDGKATLTPSNTPLGRNLSTHQTYPVVAGREMVGPTLPGYPPHIPTSGQGSYASSAIAGMVAGSEYSGNAYGHTPYSSYSEAWRFPNSSLLSSPYYYSSTSRPSAPPTTATAF..................................................................................... 384
29 -10.700[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  17  156............................................GAKRPRTTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRHRWGQFYKSVKRSRGSSKQEKESSAEDCGVSDSELSFREDQILS---------------ELGHTNRIYGNVGDVTGGQLMNGSFSMDGTGQSYQDLRDGSPYGIPQSPSSISSLPSHAPLLNGLDYTVDSNLGIIAHAGQGVSQTLRAMAGGPTSDISTGSSVGYPDFPTSPGSWLDEMDHPPF... 390
30 -9.690[O] KOG0802 E3 ubiquitin ligase  ali follow..  9  323..........................................SAILKRIKGYIKLRIAGALH-----AALPDA-TSEELRAY-PMAKAKLRSWLDQGLNECRKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLGRVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDE.................. 580
31 -9.570[T] KOG2370 Cactin  ali follow..  27  550..........................................PRKPTRVQTGFDWNK-------YNQTHYPDLLDMEDIAFKVETLHKNFQLWFMFKKYRYRR.................................................................................................................................................................................................. 667
32 -9.100[R] COG3413 Predicted DNA binding protein  ali follow..  9  164.................................................MEALTDLQVKTIKQAYVNGYYPRRCTLGDLAKINGISKNAMA-----KSVEKK................................................................................................................................................................................................... 216
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.