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Query: [R] KOG2361 Predicted methyltransferase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MTISPHWPNHDWADQLKTLQLNVLNKTLKIFFRFFLREEEPERLTSTNTDKYERDAKKYWDIFYKHHGDRFFKDRHYLDKEWNSYFSVSGKSVILEVGCGAGNTIFPLIATYPDIFVYACDFSPRAVELVKAHDEYTETRVCAFACDLTGDGLDKHISPSSVDIVTMIFVLSAVSPEKMSSVLQNIRKVLKPNGCILFRDYAVGDLAQERFSGKDQRISENFYVRGDGTRAFYFSNEFLETLFSEQGFEVEELDVCCKQVENRSRELVMNRRWVQATFRRTNGNKNPCDSLTPAKLDKSEQQLast
1 -105.000[R] KOG2361 Predicted methyltransferase  ali  100  1MTISPHWPNHDWADQLKTLQLNVLNKTLKIFFRFFLREEEPERLTSTNTDKYERDAKKYWDIFYKHHGDRFFKDRHYLDKEWNSYFSVSGKSVILEVGCGAGNTIFPLIATYPDIFVYACDFSPRAVELVKAHDEYTETRVCAFACDLTGDGLDKHISPSSVDIVTMIFVLSAVSPEKMSSVLQNIRKVLKPNGCILFRDYAVGDLAQERFSGKDQRISENFYVRGDGTRAFYFSNEFLETLFSEQGFEVEELDVCCKQVENRSRELVMNRRWVQATFRRTNGNKNPCDSLTPAKLDKSEQQ 302
2 -40.200[R] KOG2899 Predicted methyltransferase  ali follow..  30............DEKQVESKRLKKEESNVEATSRPPAQSPKKRLHLNGKPMQNKDLNFKYGNYKHYYGKRILNKHDIRLDVLGTQPDLFRNKQLLDIGCNSGHLSIQIARKFEVKSLVGLDIDRGLINDAQKTVSHLKRHATPGGNYVLEDDVLLEIERPQFDVILCLSVTKWIHDSGLKQAFRRMYLQLRPGGKLILEPQSFDGYKRRKKLSVSFIRRTIDREYSNLMYVHLSLQEQIRDLSPEVGFAEMKL-------IPEHCKVGFKRPIQ--IFTK...................... 322
3 -38.900[R] KOG1331 Predicted methyltransferase  ali follow..  12  1...........................................MSISSENVEQEYVHSIYSRLATYQQKEHKPSSPRIPRVRQFVDQQSAGSIILDVGCGEAKYT------SQKSHVIGFDTCSEVLSSSKKD----------DIDLCLADAINIPIRDDSVDAILNVSVIHHLATARRRQVLQECSRCLRIGGQMLIYAWAFEQPNGKFASQD-NMHETAIGGRLPKVKFHLNTTKEQRVIAASIPVNISDGSI............................................... 202
4 -38.600[A] KOG1975 mRNA cap methyltransferase  ali follow..  15  82.......ERYDQEERLRKQRAQKLREEQLKRHEIEMTANRSINVDQIVREHYNERTIIANRAKRNLSPIIKLRNFNNAIKYMLIDKYTKPGDVVLELGCGKGGDLRKYGAAGIS-QFIGIDISNASIQEAHKRYRSMRNL-DYQVVLITGDCFPFPDCRFPCDIVSTQFCLHYATEEKARRALLNVAKSLKIGGHFFGTIPDSEFIRYKLNKFPGQMYTYWLEDAIDNVPEYVVPFETLRSLADEYGLELVSQMPFNKFFVQEIPK-AASYFYTMFAFRKVKQYIEPESVKPN......... 436
5 -37.700[R] KOG1271 Methyltransferases  ali follow..  20  1............................................MDSELNGSELGTKEFWESSYNREIRNYSAQWRTIDWLLNEEKIDKEASRVLDLGCGNGMFLVGLANEGFTGDLTGVDYSPKAVELAQNIAEDNKLS----ITYKVADLTQPQNELGQFDVVHDKGTYDAVSKEKRALYLDTVEKLLRTADSLFVITSC.................................................................................................... 173
6 -35.100[R] KOG1541 Predicted protein carboxyl methylase  ali follow..  11  2..............................................SRPEELAPPEIFYNDSEAHKYTGRVQHIQAKMTLRALELLNLQPCSFILDIGCGSGLSGEILTQEGDH-VWCGLDISPSMLATGLSRELEGDL-------MLQDMGTGIPFRAGSFDAAISISAIQWLC--NADTSYNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDD-----------------QVDDILQSAKVAGFSNVNLKKQLRQRLKGGKDKESAKSFILRKKELMKRRGRKVAKDSKFTGRKRRHR 274
7 -34.600[R] COG4106 Trans-aconitate methyltransferase  ali follow..  12  4.......................................................SAQQYLKFEDERTR--------PARDLLAQVPLERVLNGYDLGCGPGNSTELLTDRYGVNVITGIDSDDDMLEKAADRLPN--------TNFGKADLATWKP-AQKADLLYANAVFQWV--PDHLAVLSQLMDQLESGGVLAVQMPDNLQEPTHIAMHEDGGPWKDAFSGGGLRRKPLPPPSDYFNALSPKSSRVDVWHTVYNHPMKDADSIV----WVKGTGLRPYLAAAGEENREAFLADYTRR. 229
8 -33.400[R] COG4976 Predicted methyltransferase (contains TPR repeat)  ali follow..  11  74.........LRLNPEDIFGASLKLALLGATETPEQPPSVYVERLFDDYAERFDHALVEKLGYSVPEK----------LAAVIGRVNGGGRFRHVTDLGCGTGLFGERIRDRAD--FLEGFDLSANMLAKAEAKGVYDRLAQADLSLAPEDSGVFGALEQRRADLVSAADVLMYL--GNLEGVFVIADRLLAPGGLFAFSVEDACGADGFVLRPSLR---------------YAHPEASIASLCKESGLSMIATE---RTIIRRDAGEPVAGILF--LACKPA.................... 312
9 -32.500[H] KOG1270 Methyltransferases  ali follow..  17  31.........................................TTVDSGEVKTFLALAHKWWDHSMNDLRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRL--GASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIVEETAETFDAVVASEVVEHV--IDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQI--GIVPKGTHTWEKFVSPETLESILESNGLSVQTVVMLYNPFSGYWHWSENTSLNYAAHAVKSRVQEHPASAEFVLKGETEELQ 295
10 -32.200[R] KOG2940 Predicted methyltransferase  ali follow..  13  58............................................RDLKRIHRDRAAWLSRQKNDSFVDAVADNLLDRLEDC------KKSFPTAFCLGGSLGAVKRLLRGRGGIEKLIMMDTSYDMIKSCRDAQDDSLDN-SIETSYFVGDEEFLPVKESSVDLIISSLGLHWT--NDLPGSMIQCKLALKPDGLFLAAILGGETLKELRIA---TLAHMEREGGISPRLSPLAQVRDAGNLLTRAGFSLPGVDVETNALLERNKILNRETAVIPATFQREHSSHPQAKRRGSATVSFTD.. 346
11 -32.200[IR] KOG1269 SAM-dependent methyltransferases  ali follow..  14  53.................................DRNHENESEEDRARRIDGYKSVVNSYYDLATDLYEYGWSQSFHFHEHYLAYRMGIKPGSRVLDVGCGVGGPAREITEFT-GCNLVGLNNNDYQISRCNNYAVKRN--LDKKQVFVKGDFMHMPFEDNTFDYVYAIEATVHAP--SLEGVYGEIFRVLKPGGVFGVYEWVMSDDYDSSIPKHREIAYNIEV---GDGIPQMVRKCDAVEAIKKVGFNLLEED................................................ 280
12 -31.500[H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase  ali follow..  18  2.........................................SNVDHAEIAKFEALAHRWWD---RESEFKPLHDINPLRVNWIDERAGLAGKKVLDIGCGGGILSEAMAQR--GASVTGIDMGEAPLAVARLHQLESGVAVDYRQITAEQ----AEEMPGQFDVVTCLEMLEHV--PDPASVIRACHRLVKPGGQVFLSTINRNPKAYLFAVIGAEYI--QLLPRGTHDFRKFIRPSELGAWSREAGLEVKDII................................................ 203
13 -31.000[H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis  ali follow..  12  14............................................QTVAKEQKADMVAHVFHSVASKYD---FGIHRLWKRFTIDCSGVRRGQTVLDLAGGTGDLTAKFSRMGETGKVILADINDSMLKMGREKLRNIGVI--GNVEYVQANAEALPFPDNTFDCITISFGLRNVT--EKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSRIGSMVANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESVD.................................................. 234
14 -30.700[S] COG4627 Uncharacterized protein conserved in bacteria  ali follow..  13  5..............................................................................................VVVGAGPYNNN------------IHTQEEKLSL--------------------LDRSMWEKRFTPESISAILAEHVWEHLTFREGVEAANICYDFLKPSGYIRCAVPDGFFRDE-TYQAVVQVGGPGPKDHPAASHKIVHTYETISNMFKEAGFTVKLLEYFDENGAFLCEDWNGEDGVIFRSKKFDPRNQGEQIVFPSLIVDAIK.. 180
15 -30.300[H] KOG1540 Ubiquinone biosynthesis methyltransferase COQ5  ali follow..  12  39............LSSAAEQPEQKYTHFGSKTVLKSTKQKLVGDVFSSVANRYDLM-----NDVMSLGIHRLWKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAEESTMDIVDINPDMLKEGEKRAMEQGKYFKPRVRFLVSNGEKLEEDSDSKDIYTVSFGIRNFT--DIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDVMGSMIANDYDSYQYLVESIERFPDQETFKSMIEKAGFKSAGYE................................................ 292
16 -29.400[A] KOG3045 Predicted RNA methylase involved in rRNA processing  ali follow..  12  127............EAMEATSSTTPAANSLASKLQSELLGGRFRYINEQLYSTTSRKAEALFRKDSSAFEAYHAGYRQQLNRIIKTIKKIPKTAIIGDFGCGEGKLAQSV-----PNKVYSMDLVAARSDI------------------IACNITDTPLQARTLDVAVYCLSLMG---TDLNEFFLEANRVLKLHGTVYIAEIQS----------------------------RFQDVREFVRCLNACGFDLNKKDVAVKKMRHVPKNTKMKAFSLKCLYRK...................... 357
17 -26.500[R] KOG3010 Methyltransferase  ali follow..  14  1................................................MAALSEKEAEAYLDARPRYPIDWFKK---------IAARTQDHKFAWDVGTGNGQAAIGLVEHYE--NVVATDINEAQLQRAIKHSRISYH--HTPTTISEDEMVDLLGGENSVDLIVAAQAVHFF---DLNVFYNVAKRVLRKEGGLIA........................................................................................................ 134
18 -26.300[R] COG4798 Predicted methyltransferase  ali follow..  12  70....................................FAQVPANIAKAVADPSRPAAETARDAARRPGE-------------ILAMAELKPGDTVVDYIMGGGYFTRIISGAGPQGVVYAYQPAEFIRFAARYGESLKAVTAAANSKPLDGPITALDLPD-NVDAVITVQNYHDMPTDTAAKANAEIFKSLKPGGVFLVIDHSAIAGSGITAADT----------------LHRIDIAAVKQEVEAAGFKLEAESGLLADPADART--KTDQFIL--KFRKPK.................... 298
19 -26.000[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  19  1.............................................................................MIEVAEFIAREVKKGKVIEVGIGFYTRIAKRLKEL-GFDVLAIDINKDAVVNAKNS-----------LNAEVDDIFNPNISYMGAKAIYSIRP-----TPEMMNYILKISKAVKVPAYIVP........................................................................................................ 106
20 -24.300[J] KOG3420 Predicted RNA methylase  ali follow..  12  47.........................................................................................EGKKLIDIGCGCGMLMTTAATMYELETVLGVDIDDEALKICSRNLETAEVQDRCELLQADILDPESDLPRGTFDVAVINPPFGTKNNAGIMQFVQIGLQMVRPGGSVFS........................................................................................................ 156
21 -24.300[E] KOG2352 Predicted spermine/spermidine synthase  ali follow..  15  5................................................NEPQSFTDPAYWKNFFAKRKSPFEWYGDYNSLSNVIDKYLKPKDTFLQLGCGNSELATQLYDNG---CIHSIDVEPSVIATQIRKNKE-----RLGMTFETGDAANLSMADEAHTIVIDKGTLDALDEALVTKMFEEVHRVLASGGRYIIVTLAQPHIT............................................................................................... 165
22 -24.200[J] COG1889 Fibrillarin-like rRNA methylase  ali follow..  14  23.............................EDGTERIATKNLTPGRRVYGERLIKWGGDEYREWNPYRSKLAAAILNGLKLV-----PIKEGTHILYLGAASGTTPSHISDIGENGLIYSVEFSPRVFREFMEKLVDQGRR---NVVPILGDARFPYQYAHYVKGVDVVYIDVA-QPAQAKILADNADYFLKPGGHVMLVIKAMSIDVTAPATE---------------------TFKQEINTLKERGFDILET................................................. 217
23 -23.800[QR] COG0500 SAM-dependent methyltransferases  ali follow..  12  87..............................................................YFSSFATSWVSHAKNYCDEITERLELNDNSFVVEIASNDGYLLQHFLPK--NIPILGIEPAANVARTAIAKGVPTLVDF-----FGSRLALEMIGEGRKADLIIGNNVLAQV--PDLNDFVRGMQLLLKPEGLLRWN....................................................................................................... 214
24 -23.400[R] KOG4300 Predicted methyltransferase  ali follow..  12  270...................................SHASTSTEDLKRLRPPKPDWYEEFFAWSMNSEVSDYKMKLFDNLV--------GKAEKVLEIGIGTGPNF-KYYTDIPNVSVIGIDPNAKMESYARKSATEAGLKPEE-FTFVHALGESIPLEDASVDAVVGTLVLCSVT--DVTQTLKEIKRILRPGGIYIFIEHVAAEDGTFLRLVQ-TVLDPLQQVVADGCHL----TRHTGESILEARFNGGADVKKTSLSR-----LAYISSHVYGMMTRVLSSPSSHVSSLKYSPRRVIRA 514
25 -22.200[G] KOG2798 Putative trehalase  ali follow..  10  109............DPSEFDEPPPNVRHGDMDQIDIPFDEADVEPLKILKAQSTLKLIARDWST-ALEREQSYKPIIDSIVAYFKHSDFELKDIKILVPGAGLGRLTYELACLG---SCEGNEFSYFMLIASNPDVCPLKNPPKGHFEIAAGDFLEVYKTPNAYNCVATCFFIDCAN--NVIDFIRTIYKILVPGGIWVNLLYHFSDVSGQNSIE--------------------PAFEDLCIIMESVGFVIEKSRTGIRTKYAQNPSSMKQSEYQSLFWRKPDLFEEQRGKRKASREPHDLI. 415
26 -22.200[I] COG3963 Phospholipid N-methyltransferase  ali follow..  12  1...................................MALNLKQRLEQKFEEEI-----RFFKGMVSQPKKAIVPTSSITAKKMASVINPHSGLPVLELGPGTGVITKAILARIKPESLTAIEYSTDFYNQLLRSYPG--------VNFVNGDAFDLDHKGQMFDSVISAVPMLNFPMAARIKLLDELLKRVPHGRPVVQISYG.................................................................................................... 162
27 -22.200[M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases  ali follow..  10  122....................RRFQQMNTISRSSSNIKSHYD--LSGELYDLFLDPDKQYSCAYFDPPNATLAEAQLAKKRHIAAKMLVKEGDKVLDIGCGWGGMGLYLARHL-KANVTGVTLSEEQHAIANQRARDEGLA--DRAKFELTDYRNI---NDKFDRLVSVGMFEHVGVGHFAEYFQHVARLMKPDGVFLLHAIGRSD---------------GPGATNPFIRKYIFALSEVLPHIEKAGLYVTDIEILRLHYAETLKDERFCRMWFHIQITHRQEAVPLTRNYIEAEEKRLKRL 421
28 -21.500[J] COG2813 16S RNA G1207 methylase RsmC  ali follow..  16  227..............................................................................ARFFMQHLPENLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALS-GVEPFRFNAVLCNPPFHQLTDNVAWEMFHHARRCLKINGELYIVA--------------------NRHLDYFHKLKKIF--GNCTTIATNNKFVVLKAVKLGRR........................................... 387
29 -20.600[J] KOG3191 Predicted N6-DNA-methyltransferase  ali follow..  17  55........................................................................................RDPKLVLEIGCGSGVVSTFVNQALGNVTSVATDLNPHALDVTLETAKLNDIKIDVVRTDLFAGLENL---LGKVDVLLF----PYVPTDELDRLLPRVPELLSPRGVFYL........................................................................................................ 179
30 -19.800[R] KOG3115 Methyltransferase-like protein  ali follow..  15  79........................................................................................NKKVEIVDIGCGYGGLTVALGPQFPDTLVLGMEIRMQVSDYLKEKIQALRYRADKNISVLRMNCQKF-FEKGQLSKMFFCF--KHKNRIITSTLASEYAYFIRPHGTLYTIT...................................................................................................... 208
31 -19.300[R] COG4076 Predicted RNA methylase  ali follow..  18  19..............................................................................LAAFREAISSRARGLTYDLGAGSG--ILSFFASEYADRVIAIERDPKIAACAGENLSGLDN-----VSVVNEDALHYEF--SAADTIICEMLDTALIDEEQVPVLRRALKFLRNDGTVI......................................................................................................... 128
32 -19.200[R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase  ali follow..  22  37........................................................................................NDHPIHIEVGCGKGAFITGMAALHPEINYIAIDMQLSVLSYALDKAIEADLP---NVQMMLVDGAAL-FADGEIDQVYLNF--HEKRRLTYKSFLATYEKILRPEGEIHFKT...................................................................................................... 153
33 -19.000[J] COG2890 Methylase of polypeptide chain release factors  ali follow..  14  70.........................SRLTSSERLRVVERVIKRINDRTPVAYLTNKAWFCGLEFFVDSRVLVSPIGELIQNRFEPWLTEEPTRIMDLCTGSGCIAIACANAFPEAEVDAIDISVDALNVAEQNIQDHG--LEQQVFPIRSDLFR-DLPQEQYDLIVT----PYVDQEDMRRILANAPLYLKENGILVCE....................................................................................................... 265
34 -18.900[H] COG2242 Precorrin-6B methylase 2  ali follow..  14  54.........................................................................SKREVRLLIISALQLKEESIIWDIGAGTGTIPVELALLCPRSRIVAVERDEEVAGLIRRNCERFGVTNVTVHEGSAPDCLPLIAHPTHI------------GGRPIKQILQETWAHLAPGGRLVATANNLE------------------------------SLYGISETLSELQVEVVQAGVNRLEKRGLQQIFAAVDPTFILAGEKLS.................... 227
35 -18.900[R] COG4123 Predicted O-methyltransferase  ali follow..  11  1...........................................MEEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPRFPKKGLIVDFCAGNG-AVGLFASTRTQAQILSVEIQERLADMAERSVRLNGLEEQMQVICDDLKNMPAHIQGSKVDMILC-LLARHEITTNLEEICRSAQSILKSNGRLAM----------------------------------VHRPDRLLDILDT--LKRHNLAPKRLQFVYPKREKEANMLLIEAI......................... 215
36 -18.000[R] COG2521 Predicted archaeal methyltransferase  ali follow..  13  124........................................................................................RAWGRVFECCTGLGYTAIEALKKGAR-HVITVEVDPHVLTLASLNPYSRGLW-SPAVDVILGDCYAFTVRDSSIDFIIHDPPRLSHATQRLEALYREFYRILKRGGGVFHYVSQSGTKYRGLNP------------------------KGVAERLRRVGFAVEKIKEGYGIYARRR...................................... 278
37 -17.800[J] COG2263 Predicted RNA methylase  ali follow..  11  7..................................................EMLLEEVEGFSSPELELEQYQTPSPLAAEILHFAYMQGDLDESVQDLGCGTGILAIGAKLLGAR-KVVGYDTDPKALEVARKNAERLGVE----VEFVCSDIKKV---SGHVKTTLM----PPFGARVKGRDRPFLSSALRTSEVIY......................................................................................................... 142
38 -17.000[O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase  ali follow..  14  1.........MDIEKSRFNMIEQQIRPWDVLD------LDVLDLLAIVKREQYEAYRTLAFVDMEIPLPGGQNMLPPRVEARVLQELAVRKHEDVLEVGAGSGYMAALLAHRGR--HVTTVDIAPELVAFARDNLARNGVT---NVDVVQGDAGQ-GWGNSLYDVICVSGSVPAVP--------ESLLAQLKVGGRLSI........................................................................................................ 171
39 -16.500[J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases  ali follow..  20  84................................................................................LIVAYAGISPGDFIVEAGVGSGALTLFLANIGPEGRVVSYEIREDFAKLAWENIKWAGFD--DRVTIKLKDIYE-GIEEENVDHVI-------LDLPQPERVVEHAAKALKPGGFFVA........................................................................................................ 192
40 -16.500[O] KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase  ali follow..  7....................................AGEDNDDLIDNLKEAQYIRTERVEQAFRAIDRGDYYLSAPCIYSEVMEALKLQPGLSFLNLGSGTGYLSTMVGL-GPFGINHGIELHSDVVEYAKEKLESFIKNSDSFPAFVVGNCLQIASDSHQYDRIYCGAGVQKDHEN--------MKILLKVGGILVM--------------PIEDQLTQIMRTGQNTWESKNILAVSFAPLVQPSKNDNGKPDSVGLPPCAVRNLQDLARIYIRRTLRNFINDEMQAKGIPQRAPPKRKRK 279
41 -16.400[S] KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2  ali follow..  13  649............GEYASFRMTPPDAAEALILAVGSDTVRIRSLLSERPCLNYNILLLGVKGPSEERMEAAFFKPPLSKQRVALKHIRESSASTLVDFGCGSGSLLDSLLDYPTSLTIIGVDISPKGLARAAKMLHVKLNKEAKSATLYDGSILEFDSRLHDVDIGTCLEVIEHMEEDQACEFGEKVLSLFHPKLLIVST....................................................................................................... 841
42 -16.300[R] KOG2904 Predicted methyltransferase  ali follow..  131.........................NVKLRASLEELYDLWRQRIEKRRPFQYVVGCEHWRDLVLCVEEGVLIPRPETELIVDMVEELVTRDEIWADLGTGSGAIAIGIAKVGSRGRVIATDLSPVAIAVAGHNVQRYS--LEGMIEVREGSWFELKDLEGKLVGLVS----PYIPSDDIFHLCHGASRMLQPGGFFVFETNGEKQ------------------------------SKMIVDYMMTSDLK..................................................... 353
43 -16.100[J] KOG2539 Mitochondrial/chloroplast ribosome small subunit component  ali follow..  10  111.............KKLRDEVKRKLKSGKKDEISDFDKESFGGKVQEAQQYEIRNEVDRIMKKENFNWKPLEITTKESAAAYSLARLAPNQPETVLDFGSGAGAGFWAIQNKWPDVEITMVDLSDAMMKFSMDSLRNEQSSRPFVHNNVNFRRHLIPSLNTTYDVVLAHRVLCEIGSETRLQLIESLWK--RTNRFLILIE--------------------------SSQTGAFGGLLEARDFLLTQGTLVDY.................................................. 346
44 -15.900[R] KOG3178 Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases  ali follow..  15  183....................................................DERFGKVFNRAMLESSTMVTE------KVLKFYEGFKDVKTLVDVGGGLGNTLGLITSKYPHLIGINFDL-APVLANA---------HSYPGVNHVAGDMFKIP----KGDAIFMKWILHDWTDEQCVAILKNCWKSLEENGKLIIVEMVTPVEAKSGDICSNIVFGMDMTMLTQCSGGKERDLYEFENLAYASGFSRCAI................................................. 364
45 -15.800[Q] KOG1663 O-methyltransferase  ali follow..  10  16..............GEDQKQSQNLRHQEVGHKSLLQSDDLYQYILETSVYPREPESMKELREVTAKHPWNIMTTSADEGQFLNMLIKLVNAKNTMEIGVYTGYSLLATALALPE-KILAMDVNRENYELGLPIIEKAG--VAHKIDFREGPALPV--NHGTYDFIFV------ADKDNYINYHKRLIDLVKIGGVIGYDNTLWNGSVVAPPDAPMRKYVRYYRDFVLELNKALAADPRIEICMLPVG....................................................... 249
46 -15.700[R] COG3897 Predicted methyltransferase  ali follow..  11  4.......DPERFILDNAAIMHPPHVPELRLHLATEAHELWLKT---EEELEEIGLPPPFWAFAWAGGQG--------LARYILDHPESVCGKRVLDFASGSG--LVAIAAAKAGAKVLAADIDPWTETAIRLNAALNGVDIGFTGLDLVG-------KPVDADVLLAGDVF--YDRAFADLLVPWFVELTEKGMIVLVGD...................................................................................................... 175
47 -15.600[A] KOG2793 Putative N2,N2-dimethylguanosine tRNA methyltransferase  ali follow..  15........................................GTKLSIQQDNGSMHVGTSVWPC-FAERWSTLDSSSSTTSPNPYAELFDFRRRRGIELGTGCG-VAGMAFYLLGLTEIVLTDI-APVMPALKHNLKRNKTALGKSLKTSINNRDQISALKPPFDLVIAADVVYI--EESVGQLVTAMELLVADDGAVLLG....................................................................................................... 177
48 -15.600[NT] COG1352 Methylase of chemotaxis methyl-accepting proteins  ali follow..  10  53.............YSRLSKHIRNLGLSGFREYCALVSSSEGAQPRREMLSHLTTNFTRFF-----RENHHFEHLRDEVLPGLIARAKSGGRVRIWSAACSDGQEPYSIAAADYDFKILATDIDPKILAQARAGVYDDNAKVKRLITFNELNLMTQWPFKGNFDVIFCRNVVIYFDEPTQVRIWSRFAGLLPEGGHLYI........................................................................................................ 269
49 -15.500[J] KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14  ali follow..  12  236...............................................................................NMILSMMDINPGDTVLEAGSGSGGMSLFLSKAGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDLTFDAVA-------LDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELA--------------LSCEKISEVIVR--------DWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEES 440
50 -15.200[J] COG2264 Ribosomal protein L11 methylase  ali follow..  17  158.........................................................................................QDKTVIDFGCGSG-ILAIAALKLGAKSAVGIDIDPQAILASRNNAEQNG--VADRLQLFLSEDKPA---DLKADVVVA-----NILAGPLKELYPVIRQLVKPNGVLGLS....................................................................................................... 256
51 -14.700[L] KOG2671 Putative RNA methylase  ali follow..  206.............................................................................MAFLMANQAKATSGKLVYDPFVGTGSIL--VSAARFGAMTMGADIDIRVVRDGRGPDCNVWSNFKQYVALLRMDNNVPPWLKEIFDAIICPSTGAYSLVECVHDLLHLAARMLVMKGRLVF------------------------------FPVLRDETGSEVKFPEHPCFKLVAVSEQI--------SSRYSRVLL--TMVKVEPYSEEVEEAARLMHLEFREN 435
52 -14.700[Q] COG3315 O-Methyltransferase involved in polyketide biosynthesis  ali follow..  12  2MAATPEFGSLRSDDDHWDIVSSVGYTALLVAGWRALHAVGPQPLTASRDPYLMNLLANPGTSLNETAFPRLYGVQTRFFDDFFSSAGDTGIRQAVIVAAGLDSRAYRL-KWPNGATVFEID-LPKVLEFKARVLAEQGAIGRSEVAADLRADWPRALKAAGFDAWSVEGLLPYLTNDAQSALFTRIGELCAPGSRIAVGALGSRLDRKQLAALEATHPGVNISGDVDFSALTYEPKTDSAQWLAAHGWAVEP.................................................. 269
53 -14.500[L] COG1041 Predicted DNA modification methylase  ali follow..  18  178.......................................................................................TKATREVLDPFMGTGGML--IEAGLIGLKVYGLDIREDMVEGAKINLEYYGIR---DYVVKVGDATKIEFPGKTFEAVATDPPYGNSTTLPMDRSLESIHSVLEGRLAIAFP-----------------------------------ADFDARDVAESIGFKVLGRFYQR............................................. 315
54 -14.400[R] COG1568 Predicted methyltransferases  ali follow..  10  148.........................................................................................ENKEIFVLGDDDL-TSVALMLSGLPKRIAVLDIDERLIKFIEKVADELGYN---DIEIFTFDLRK----LHKFDTFIT------ETIKAIRAFVGRGIATLKGPRCAGYFGITRRESSLDKWR------------------------EIQRLLINEFNVVITDIIRNFNEYVNWGYAQETRAWRLIPVKKLPEYN.................. 313
55 -14.200[R] COG4122 Predicted O-methyltransferase  ali follow..  12  50...............................................................................QFMALLVQLLGAKKTLEVGVFTGYSSLIVALALPA-KLVACDINEEFTAIAQRYWQKAG--VDHKIDLYLAPALET--EAETFDFAFI------ADKSNYDNYYERSLQLIRSGGVIAI........................................................................................................ 168
56 -14.100[R] KOG2920 Predicted methyltransferase  ali follow..  12  122............PGFQHVKLSVVKTILLKENFPGENIVSKSFSSHSDLITGVYEGGLKIWECTFD------------LLAYFTKAKVKFAGKKVLDLGCGSGLLGITAFKGGSK-EIHFQDYNSMVIDEVDEENDVNEPDVKRCRKPKVTQLYKCRFLFVKYDLILTSETI--YNPDYYSNLHQTFLRLLSKNGRVLLA-----------------------------SKAHYFGVHLFQKFVEERDVFKTRI---------KIIDEGLKRFIIEITFKFPG.................... 372
57 -14.100[OKT] KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes  ali follow..  16  175.............KKLKLQNQLLISQLEEIRKDKMNELTSQTTDQLSVTPKKADNDSYYFESYAGDIHFLMLNDSVRTEGYRDFVYHNKAGKTVLDVGCGTG-ILSMFCAKAGAKKVYAVDNSD-IIQMAISNAFENGLA--DQITFIRGKIEDISLPVGKVDIIISEWMGYALTFESMIDSVLVARRFLAPSGIMA......................................................................................................... 359
58 -13.900[S] COG4301 Uncharacterized conserved protein  ali follow..  13  12.............................DAGHLALRRDVYSGLQKTPKS-YDTVGSELFDQITRLPEYYPTREAEILRARSAEVASACRADTLVELGSGTSEKTRMLLDAGSLRRFVPFDVDASVLSATATAIQREYSGVEINVCGDFEEHLTEIPRGGRRLFVFLGSTIGNLTPGPRAQFLTALAGVMRPGDSLLLGTDLVKDAARLVRA----------YDDPGGVTAQ-FNRNVLAVINRELEADFDVDAFQHVARWNSAEER--IEMWLRADGRQRVRVGALDLTVDFDAGEEMLTE 282
59 -13.700[V] COG3510 Cephalosporin hydroxylase  ali follow..  3.........LVWRSRTSLVGQLIGLVRLVASFAAQLFYRPSDAVAEEYHKWYYGNLVWTKTTYMGINCWKSVSDMWNYQEILSEL----QPSLVIEFGTRYGGSAVYFANIGQPFKVLTVDNSHKALDPRARREPDVLFESSSTDPAIAEQIQRLKNEYPGKIFAIL----DH-SMNHVLAEMKLLRPLLSAGDYLVVED...................................................................................................... 191
60 -13.600[M] COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division  ali follow..  11  10.....................................KDAGISLTDHQKNQLIAYVNMLWNKAYNLTSVRDPNEMLVRHILSIVVAPYLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLENIEPVQSRVEEFPS----EPPFDGVISRAF------ASLNDMVSWCHHLPGEQGRFYA........................................................................................................ 163
61 -13.300[R] KOG2497 Predicted methyltransferase  ali follow..  12  129....................................SRKLVIPLHCSLNMLEGDTGCSIWPS------------SLFLSEFVLSFPELFANKACFEVGSGVG-MVGICLAHVKAKEVILTDGDLLTLSNMKLNLERNHLNYDDEFLKQPETASESELSQYRPDIVLGADVI--YDPSCLPHLLRVLVALLKNPPKRGNGSLETEDRDTTQEEHSPAVAYIASVIRNVDTFNVCL------TLADQMDLSITDVTAELTPRFELLPSYDRSTVRLFSISSR...................... 369
62 -13.300[R] COG4262 Predicted spermidine synthase with an N-terminal membrane domain  ali follow..  12  219...................SDRLTHWSERALFGDEIIHAISSPYQRLVVTRWKDDLRLYINGNLQFSSRDEYRYHEAL--VLPALESVRGARRVLVLGGGDGLALRQILKYPQVEHVTLVDLDPRMTSLFSHAEALVALNQHAFVTVVNADAGQLQTAADMFDVAIVDFP-FSIGKLYSVPFYRLLSRHVADTGLVVIQ....................................................................................................... 404
63 -12.800[D] KOG0822 Protein kinase inhibitor  ali follow..  11  330.............RNVNYRSRPDVGEGSNDSTHYLNVIEYKDVLQAPLQPLSENLDSGVYNTFEQDQIKYDVYGEAVVGALKDLGADGRKTVVIYLLGGGRGPIGTKILKSEREVKLYIVEKNPNAIVTLKYM---NVRTWKRRVTIIESDMRSLPGIFEQPDIIVSELLGSFGDNELSPECLDGVTGFLKPTTISI......................................................................................................... 528
64 -12.600[R] COG2933 Predicted SAM-dependent methyltransferase  ali follow..  14  182............................................................ADAPSRSTLKLEEAFHVFIPADEWDERLANGMWAVDLGACPGGWTYQLVKR--NMWVYSVDNGPMAQSLMDT----------GQVTWLREDGFKFRPTRSNISWMVCDMVEK---PAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSH----------------------NLAYIQAQLDEHGINAQ-----------QARQLYHDREEVTVHVRRIWAAVGGRRDE........... 365
65 -12.500[J] COG5459 Predicted rRNA methylase  ali follow..  11  82.................PDVSKAINNNIMAVHIPNNLRRVATNYYKEIQEPNSLHRPCRTKMEVDAHLQNYGSIFQSLKELQKRVGPDNKPQRILDVGYGPATGIVALNDILGP-ERAKIILSRQLNEVVDTVEENVSTEKEQETDRRNKNFQE---ASKEYDLIILTHQLLHDGNQQVDENIEHYLNILAPGGHIVIIERGN................................................................................................... 313
66 -12.400[J] COG0144 tRNA and rRNA cytosine-C5-methylases  ali follow..  12  149.HSFPDWIIKVWWEQLGLTETEKLCEWMNQTPTLDLRVNPLLASVAEVETALKSAGVLA--QKLPGFSQGWWIVQDASAQLVGHLLDPQPGEVIIDACAAPGGKTTHIAELMKD-KVWAGDRTASRLRKLKENAQRLNLHS---IEICIGDSRNLPQFYDVADRVLLLGTLHRHADMLQKELLAHTSKFVKVGGVLVYAT...................................................................................................... 382
67 -12.200[R] COG2384 Predicted SAM-dependent methyltransferase  ali follow..  12  1.......................................................................MNEIKLSKRLKAVANYVDNGARLADIGSDHAYLPTYLMQKLVIDFAVAGEVVKGPFEIAKNHVSEADLS--DRIEVRLANGLGAIENTDKIDTI----VIAGMGGILISEILEAGKEKLGHVKRLILQPNN--------------------------------HEESLRQWLVNHQFVIKKEEILLE............................................ 149
68 -12.100[E] COG0421 Spermidine synthase  ali follow..  14  83....................................................................................LNSHPNPKKVLVIGGGDGGVLREVVKHECVEEAILCDIDEDVIKVSKQYLPEMSAGFNPKVKVHIGDGFKLQDYQNTFDVIITDSSDPDGPAEALKPYFQLLSDALRGGGVITTQ....................................................................................................... 201
69 -12.000[S] KOG2912 Predicted DNA methylase  ali follow..  74........................................................................................KKRIIGLDIGTGASCIYPLLGCRMYSYDFVGTEIDKFSFETAKSNILQNNMQIKIVLRSKQDCLLPDTEGMEEFTFVMC----PFYEHEEDFINFKQNPEMVTEGGEVGFANKILTESKKRKGIQWYTCMFGKKS-----------SVPAVVDKLREQNISNYGIYELALGKTKR....................................... 247
70 -11.800[R] COG2520 Predicted methyltransferase  ali follow..  13  53................SKILSMRGNTRAVLNKVSKLEGEHRVARFELLSGDSAETLHRENGYTYRMDIRKVFFNPRLYWERARVASKVLPGESVLIPFAGVGPFVLPSAGK--GAAVCAIEINPDACACLKENVRLN--RLEGQVTVIQGDAEYI--PENGFDRAIV--------PYDMDHFLGEVSGNVRKEGKIHFYTFKTDS................................................................................................. 243
71 -11.600[R] KOG2782 Putative SAM dependent methyltransferases  ali follow..  13  1...............................................MKRLLNPTRLRLDWLRRSSIDVTTAPHVPVLCDTAIEYLQPVPGGTYFDMTFGAGGHTRRLLEKCPEAKVYALDRDPLAHQLARDMSESEEFKLLGKFSDLPKLFKEHGLAKNSVDGMLFDFGCSSMQFDEAVRGFS-----ISRDGPL--------DMRMDGGHSGGVTAAD---------VLANVEEGDLVKILRMYGEEKAAKKIARGLVDARNALFKIETTKQLADIIENIMDGGTRKDKLRRPAHSATK. 237
72 -11.300[D] KOG4589 Cell division protein FtsJ  ali follow..  10  4................................TKKSQGNLHKYIQRQSTDEFAVKAREHNYRARSAFK---------LIEINEKFKFLKPESTVIDIGCAPGSWLQVVVQKPNGYASGVDLQNV-------PIRGADILSLSDITDPAVKLKIREKLAHRQVDVVLSDMALIELCRSVFRLFSVENEIELVKNGVYLCKIWDGSARAEF--------------------------VRELSDRFSTV-----------KTVKPTACRDNSAELYLFCRFKK...................... 214
73 -11.000[J] COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase  ali follow..  12  119.........MIYHKRLDDEWMQAAQALQQQLDTSVIGRSRGQKIVLKQDYVTETLKVGNRDFRYRQIEGGFTQPNAAVCQKMLEWAAEGLGGDLLELYCGNGNFTLPLSEKFE--RVLATEISKTSVGAAQWNIEANGIGNIKIARLSAEEFTEIALTDYAFSTIF-------VDPPRAGIDEETLKLVSQFDNIIYIS....................................................................................................... 317
74 -11.000[DR] KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ  ali follow..  15  5.......................................................SRDKRDIYYRKAKEEGWRARS-LLQIDEEFNIFEGVKRVVDLCAAPGSWSQVLSRQGDLPLIVAIDLQP-------APIEGVIQVQGDITNARTAEVVIRHFDGCKADLVVCDGA-EFVQSQLILAGLTIVTHILKEGGKFIAKIFRGKDTS............................................................................................... 174
75 -11.000[J] COG1189 Predicted rRNA methylase  ali follow..  11  56.........................................................................................NGKTCLDIGSSTGGFTDVMLQNGAK-LVYALDVGTNQLAWKIRS----DERVVVMEQFNFRNAVLADFEQGRPSFTSIDVSFISL-----DLILPPLYEILEKNGEVAALIKPQFEAGREQVGKNGIIRDPKVHQM---------TIEKVLKTATQLGFSVKGL------TFSPIKGGAGNVEFL-VHLLKDGKAEIAQQVNIESVLQKESEE 242

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Godzik A., Rychlewski L. A support vector machine approach to the identification of phosphorylation sites. Cell Mol Biol Lett. 2005;10(1):73-89.