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Query: [K] KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MGIIENGTISGNLPSKEAFVVHYPGYPSSISRAVETLGGIQGITTARESTSNKLELHFRPEDPSAHPAYGERRHCNGFLLKISKEDVKKDSLPESQPVISTSDACLPEVRPALCADIVARVSESYCFDGMVDYQHVIPIHADIAQQKKRKWMEVKSLAGKNDLMDMADEDVMMLLPQFFSPKDRPDNLVLRLPVTSSPKKKDEELTQNLYESLAFIQIPKILKWEDYIVPTSNQWKWQVAVSALFEERPVWTRDSIVQRLLDKGLTCTHHMLNRFLLRAAYYFSGGPFLRFWIKRGYDPRKDPESRVFQRMEFRVPPELKGYCDSNATNKSKPSWDDICAFKVFPFKCQTFLQLFELDDEYIQQEIRKPPKQTTCNYKTGWFSEALLDNLRLRVAVRFVSVFPEPGFEDVFKSIQEEFERSEKTRIQKDALQPSQRNHQETTKDMKKCKNTNKEKDDDVNADEDSEDLDDEYEEAANDDDISISSHGYGDMENNSRTYLQGLFNRFPSSASALYGSANDDNDSDGEYPIYEQESNALDDDEEDDELast
1 -153.000[K] KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit  ali  100  1MGIIENGTISGNLPSKEAFVVHYPGYPSSISRAVETLGGIQGITTARESTSNKLELHFRPEDPSAHPAYGERRHCNGFLLKISKEDVKKDSLPESQPVISTSDACLPEVRPALCADIVARVSESYCFDGMVDYQHVIPIHADIAQQKKRKWMEVKSLAGKNDLMDMADEDVMMLLPQFFSPKDRPDNLVLRLPVTSSPKKKDEELTQNLYESLAFIQIPKILKWEDYIVPTSNQWKWQVAVSALFEERPVWTRDSIVQRLLDKGLTCTHHMLNRFLLRAAYYFSGGPFLRFWIKRGYDPRKDPESRVFQRMEFRVPPELKGYCDSNATNKSKPSWDDICAFKVFPFKCQTFLQLFELDDEYIQQEIRKPPKQTTCNYKTGWFSEALLDNLRLRVAVRFVSVFPEPGFEDVFKSIQEEFERSEKTRIQKDALQPSQRNHQETTKDMKKCKNTNKEKDDDVNADEDSEDLDDEYEEAANDDDISISSHGYGDMENNSRTYLQGLFNRFPSSASALYGSANDDNDSDGEYPIYEQESNALDDDEEDDE 545
2 -14.200[K] KOG2478 Putative RNA polymerase II regulator  ali follow..  9  389..................................................................................................................................................................................................................................................................................................................................................................................................................KEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD 531
3 -13.400[K] KOG2905 Transcription initiation factor IIF, small subunit (RAP30)  ali follow..  9  13..............DRSIWLMKCPVVVDKAWHKIAASSSSSFASSDSPPDMAKIVREVDPLR--------DDSPPEFKMYMVGAEYGNMPKCYALNMFTDFVPMGGFSDVNQGCAAAEGKVDH--------KFDMKPYGETIEEYARLCRERTSKAMVKNRQIQVIDNDRGVHMRPMPGMLGLVSSNSKEKRKPPPVKQTEVKRT-------------------------RRDRGELEAIMFKLFEGQPNWTLKQLVQETDQ------AQFLKEILNELCVYNKRGSNQGTYLKPEYKKSAEDDTG............................................................................................................................................................................................................................................... 259
4 -12.000[KB] COG5137 Histone chaperone involved in gene silencing  ali follow..  11  120..................................................................................................................................................................................................................................................................................................................................................................................................................GLNLQEMDDAEIKKVKVDISKVWRSILAEKPRVTRFNIQWDNPDFDDAPPVQPDADEEEEEEEADEMEEEFDEEGEGDEEEEEEDDGDGDGEGDGDGEGENDGKGSEEEEEEEIDIEEEEEESALANASAAEEKPEEKPETSQ 262
5 -11.100[K] COG3343 DNA-directed RNA polymerase, delta subunit  ali follow..  9  87..........................................................................................................................................................................................................................................................................................................................................................................................................................................................DEIDEEIITLEEDEDGAQKRKKKRVNAFMDGDEDAIDYRDDDPEDEDFTEESAEVEYDEEDPDDEKSEVESYDSELNEIIPEDDFEEVDINEEDEEDEEDEEP 189
6 -10.900[KB] KOG3265 Histone chaperone involved in gene silencing  ali follow..  11  194..................................................................................................................................................................................................................................................................................................................................................................................................................DSFVENLSRKIETEDLRVTTFPIRWTDEDPVAEPVDEEANKVFDEDDLMPLHDDGQDDDEEEEDDDETGPNTEEVDLNESFNERMANAHDGTEQKNGEESMEHDGASGDVEMGDNQLFVQINTDTKATESMVDPLSDTTKRDF 336
7 -10.500[S] COG4530 Uncharacterized protein conserved in bacteria  ali follow..  10  37.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLSFFEETSVAKVLEKEEEEDVKEVDTENTEVELVSLEEADDEASGGDDLPDLGDDDVEIEGDDDDTFLQTDDEDDDDDMSDIIGVSDEDDD 128
8 -10.200[K] KOG4661 Hsp27-ERE-TATA-binding protein/Scaffold attachment factor (SAF-B)  ali follow..  10  30................................................................................................................................................................................................................................................................................................................................................................RLSDLRVIDLRADVRKRNV-----DSSG---------NKSVLMERLKKAIEDEGGNPDEIEITSEGNKKTSKRSSKGRKPEEEGVEDNGLEENSGDGQEDVETSLENLQDIDIMDISVLDEAEIDNGSVADCVEDDDADNLQESLSDSRELVEGEMKELPEQLQEHAIEDKETINNLDTSSSDFTILQEIEEP 208
9 -10.100[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  8  1...............................................................................................................................................................................................................................................................................................................................................................MDVRRLKVNELREELQRRGLDTR-----G---------LKTELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRG 180
10 -10.000[C] COG2009 Succinate dehydrogenase/fumarate reductase, cytochrome b subunit  ali follow..  9  1MSRHEICPEVSHKKGKYYSTF----------RCIHSLAGIAFTFFLCEHLFTNMLASSYFSQGKGFVAMVNGFHKIPGLKIIEVVYLFQGKSNCYSGDGSRPHLRYAKNYSYTWQRWTAWILLFGIAFHVVHLRFIRYPVHVDIHGTTYYAV------------------------DIQPSRYDVIVRGTKGFLTLNLPNTEASSIEVSRHDLGGADAALLSERNSYLLTPSAGTAFLYVVRDALGS-LFIALLYTILVI-----------------AAAFHGFNGLW-TFCCRWGVSLRMQGVLRIVCYLAM........................................................................................................................................................................................................................................ 279
11 -9.890[S] COG5291 Predicted membrane protein  ali follow..  6  1.....................................................................................................................................................................................................................................MPSIPQMNNTFLLGQMLRVPPITRYMTLLISAVALLVYVDAVSPYSLYYSPLFLKRLEWRHVVFLYRYSRMLEEGCVNTSEYFWLI---ISNIYGISALGTSFSATITYIWTKRNPRAIVQIFGFISFPAFYLPFIL--SRRSISIDDVLGIVVGHLFHYFKDVYPR-VKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECS...... 348
12 -9.690[R] KOG4334 Uncharacterized conserved protein, contains double-stranded RNA-binding motif and WW domain  ali follow..  5  1.................................................................................................................................................................................................................................................................................................................................................................................................................MEQESGGKKSNEQLLSEREAIMRQLAMLGSGPEDLDVDDEEEDEEEEVEKMEEGVEETMENASVVKETTPVKDENIVEDSNSSEELFPYLDSPPEDKIQEISANDTEIDQIDSPIRFEGVKNPAQKMDVDGEEGTSTDARPVSG 144
13 -9.480[R] KOG2295 C2H2 Zn-finger protein  ali follow..  7  188..............................................................................................................................................................................................................................................QQLNEFFVAHK-WFKNKYHPEDSVKRSEEQRGFLQRRTDVFMELLENG----------IGSQADALIRVLDTCVIKLEGGTDEDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVGKDKVV 493
14 -9.260[R] KOG4264 Nucleo-cytoplasmic protein MLN51  ali follow..  9  1.................................................................................................................................................................................................................................................................................................................................................................MADRRRQRASQDTEDEESGASGSDSGG------------------SPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDE 174
15 -9.080[S] KOG4852 Uncharacterized conserved protein  ali follow..  13  153..............................................................................................................................................................................................................................................................................................................................................................................................................................................................AKRDELDLGDEDDSDGPPADDEDDSNDEDNWRNDYPDEESYDEDSDNGDPYGISEPDHWHAGEEAYSDESFHRRLQNMDLNDERYEAFYEGDETDEDAD 251
16 -9.070[K] COG5090 Transcription initiation factor IIF, small subunit (RAP30)  ali follow..  10  65..............NRQVWLVRLPMFLAEKWRDRNNLHGQELGKIRINKDGSKITLLLNENDNDSIP--REEELKKKQQQQKRRNNRKKFNHRVMTDRDGRDRYIPYVKTIPKKTAIVGTVCHECQVMPSMN-----------------------------------DPNYHKIVEQRRNIVKLNNKERITTLDETVGVTMSHTGMSMRSDNSNFLKVGREKAKSNIKSIRMPKKEILDYLFKLFDEYDYWSLKGLKERTRQ------EAHLKECLDKVATLVKKGPYAFKYLRPEYKKLKEEER................................................................................................................................................................................................................................................ 363
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.