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Query: [R] KOG2485 Conserved ATP/GTP binding protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVMMLKKTVKKGLIGGMSFAKDAGKINWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNVIRFFKWTRHFESSKQDCIAINAHSRSSVMKLLDLVELKLKEVIAREPTLLVMVVGVPNVGKSALINSIHQIAAARFPVQERLKRATVGPLPGVTQDIAGFKIAHRPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQYFLAILNIRGTPLHWKYLVEGINEGPHADCIDKPSYNLKDLRHQRTKQPDSSALHYVGDMISEVQRSLYITLSEFDGDTEDENDLECLIEQQFEVLQKALKIPHKASEARLMVSKKFLTLFRTGRLGPFILDDVPETETDHPNSKRVVVLLast
1 -117.000[R] KOG2485 Conserved ATP/GTP binding protein  ali  100  1MVMMLKKTVKKGLIGGMSFAKDAGKINWFPGHMAAATRAIRNRLKLSDLVIEVRDARIPLSSANEDLQSQMSAKRRIIALNKKDLANPNVLNVIRFFKWTRHFESSKQDCIAINAHSRSSVMKLLDLVELKLKEVIAREPTLLVMVVGVPNVGKSALINSIHQIAAARFPVQERLKRATVGPLPGVTQDIAGFKIAHRPSIYVLDSPGVLVPSIPDIETGLKLALSGSVKDSVVGEERIAQYFLAILNIRGTPLHWKYLVEGINEGPHADCIDKPSYNLKDLRHQRTKQPDSSALHYVGDMISEVQRSLYITLSEFDGDTEDENDLECLIEQQFEVLQKALKIPHKASEARLMVSKKFLTLFRTGRLGPFILDDVPETETDHPNSKRVVVL 391
2 -48.000[R] KOG2484 GTPase  ali follow..  16  126.....................KYKNAVTKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRCNEVERAVGNKRLVLVLNKADLVPRENLNNWIKYFRRSGPVTAFKASTQDQANRVCIGAELLMSMLGNYCRNKGIKTSIRVGVVGIPNVGKSSIINSLTR-----------GRSCMVGSTPGVTKSMQEVEL--DSKIKLIDCPGIVFTSGGENSH--AVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYD-----TNYDTFEEFFAKKAARMGKFLKKGVPDVVAAARSVLNDWNTGKIKYCTQPPE------VQEGQSVHISASIVHSEAREFDVENFESMETEILEH................................... 457
3 -46.300[R] KOG2423 Nucleolar GTPase  ali follow..  17  148.....................ENMNPLFRAGQSNRVWGELYKVIDSSDVVVQVVDARDPMGTRCRHVEEFLPHKHLVTVINKVDLVPTWVTRKWIGELSKEM-----PTIAFHASINNSFGKGAVINLLRQFAKLHPDRPQISVGFIGYPNVGKSSLVNTLRK-----------KKVCKTAPIAGETKVWQYVMLMRR--IYLIDSPGVVYPQGDSET---QIILKGVVRENVKDPENHVQGVLDRCKP--EHLRRQYGIPE---TDVDDFLTKIAIKQGRLLKGGDPDIVAVSKVVLNEFQRGKLPYFVPPPG------CEERAKKDFSQAPINEMCADDDEQLPLDAQLELDDV................................... 456
4 -39.100[R] KOG1424 Predicted GTP-binding protein MMR1  ali follow..  19  158..............................ERNLDFWRQLWRVIERSDIVVQIVDARNPLLFRCEDLECYVKEKENVILINKADLLTAEQRSAWAMYFEKEDVKVIFWSALAHNFSHLVSKQELLELFKELHTGRKVKDGQLTVGLVGYPNVGKSSTINTIMG-----------NKKVSVSATPGHTKHFQTLYV--EPGLCLCDCPGLVMPSFVSTKA--EMTCSGILPDQMRDHVPPVSLVCQNIPRHVLEATYGINIITPREDTSEELLTAYGYMRGFMTAHGQPDQPRSARYILKDYVSGKLLYCHPPPGRDPVTFQHQHQRLLENKMNSDEIKMQLGRNKKAKQIENIVDKTFFHQ.............................. 599
5 -35.600[R] COG1161 Predicted GTPases  ali follow..  17  46..SEASIKTEDLYCQRCFRLRHYNEIAPTSLTDADFLRLLKEIGQHDALIVNVVDIFDFNGSLIPNLHKLTGGNDLLMVANKRDVLPKSLKVGKLTAWLREQAASRSKDILVTSAQNKDDVAELMEAIEYY-------RRGRDVYVVGVTNVGKSTLINAIIK------SASGSEDVITTSRFPGTTLDKIEIPLDED--SALIDTPGIIHRGQIAHYLEPEDLKYVSPRKEIKPKTYQLD...................................................................................................................................................... 272
6 -20.400[R] COG1084 Predicted GTPase  ali follow..  16  53............................IRDRLKMIIQRIPDIESLPEFYQDYIDVTVGVDELKKSLGALNWAVGILNLESDYMARIKRSKPSDASHLRREAFG----RISSVIKRIEGDLDFLDFAKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAE------------PEVADYPFTTKGIQIGHLEKWKRIQVIDTPGLLDRPVEDMN--------NIELQAMVALENIADVIMFIFDASET........................................................................................................................................... 254
7 -19.600[R] COG0218 Predicted GTPase  ali follow..  22  27..............................................................................................................................................EIALAGRSNVGKSSFINTMLN----------RKNLARTSGKPGKTQLLNFFNI--DDKMRFVDVPGYGYARVSKKERE-NLRAVVSLVDLRHDPSADDVQMYEFLKYYE............................................................................................................................................ 136
8 -19.100[R] KOG2486 Predicted GTPase  ali follow..  13  7.............................PRFHLSILAKPSFSLSSSHFSFLNPKPSVRTLFSFASKSNLATVEPIPLSVSDSTDLDDAPVEIALDKL-LTTRILKGSNIVLSKYARDAQVVQADYVKSSVKTEDCPADGLPEFALVGRSNVGKSSLLNSLVR----------RKRLALTSKKPGKTQCINHFRINDK--WYLVDLPGYGYASAPHELKQ------NKFTKDYFLNRSTLVSVFLLVDAS............................................................................................................................................. 228
9 -18.800[R] COG1160 Predicted GTPases  ali follow..  19  70.................................EKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLQNKITVVVANKTDGIDADSHCA-------EFYQLGLGEIEQIAASQGRGVTQLMEQVLAPFAEKMENDKNIKIAIVGRPNVGKSTLTNRILG-----------EDRVVVFDMPGTTRDSIYIPMEDGQQYTLIDTAGV------RKRGKVHLAVEKFSVIKTLQAIQDANVVLLTIDAR............................................................................................................................................. 308
10 -18.200[R] COG3596 Predicted GTPase  ali follow..  17  13.....................................................................................................................QNSLSGLPLWVSERILQQQLTHYEPVIGIMGKTGAGKSSLCNALFA-----------GEVSPVSDVAACTRDPLRFRLQGEHFMTIVDLPGVGESGVRDPRLDLILWLIKADDRALATDEHFYRQVI................................................................................................................................................... 142
11 -15.100[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  14  49.......................RKVKYTQTNFHAKLSAIIDEFPRLEQI-DLLHVLYNKDHYKLALGQVNTARNLISKISKDYVKLLKYGD---SLYRCKCLKVAALGRMCTVLKRITPSLAYLEQIRQHMARLPSIDPNTTVLICGYPNVGKSSFMNKVTRAD------------VDVQPYAFTTKSLF-----KYLRYQVIDTPGILDRPFEDRNIIEMCSIT..................................................................................................................................................................... 242
12 -15.000[R] COG1159 GTPase  ali follow..  25  11...............................................................................................................................................IAIVGRPNVGKSTLLNKLLG-----------QKISITSRKAQTTRHIVGIHTEGPYQAIYVDTPGLHMEEKRAINRLMNKAASSSIGD--------VELVIFVVE............................................................................................................................................... 97
13 -14.900[R] COG1162 Predicted GTPases  ali follow..  17  115.....................................GGEQLIAANLDTIFIVTSVGKDLNLR--RLERYLSGASPVILLNKIDLADDPA-----RLVEKIRDVTGDVPVIPLSALSKTGLDALGPYL----------NPGETVALVGSSGVGKSTLINAFLG------ETVQKTADIRKDDEKGTTTVRQMFLLPNG---VLIDNPGIREIQLGDSAEGLECAVLQAVRDGIIPEERLESYHRLTDELSFQSKKAEIGLKRLEKERYREMAVNIKKYRKFTGK........................................................................................................... 368
14 -14.700[R] COG0486 Predicted GTPase  ali follow..  17  119.............................PGEFEQAFLNDKLDLAQAEAIADLIDASSEQAARSA-LKSLQGEFSNKVNQLVDSVIYLRTYVEAAIDFPDEEIDFLADGKIEAHLND---IITQLDHVRSEAKQGSILREGMKVVIAGRPNAGKSSLLNALAG-----------REAAIVTDIAGTTRDVLREHIHID-PLHIIDTAGLREATDEVERIGIVRAWSEIEQADRI............................................................................................................................................................. 310
15 -14.000[J] KOG1191 Mitochondrial GTPase  ali follow..  18  246.............................PGEFLRAFLNGRLDLSQAENVEKLISAKSSAAADAA-LEGIQGGFSSLVKSLRAQCIELLTEIEARLDFEDEMPPLDIESVI----NKITSMSQDVESALDTANYDKLLQSGLQIAIVGRPNVGKSSLLNAWSK-----------SERAIVTEVAGTTRDVVEANVTVR-PITLLDTAGIRETNDIVEKIGVERSETAAKVADVI............................................................................................................................................................. 436
16 -13.600[R] COG1163 Predicted GTPase  ali follow..  22  67..............................................................................................................................................SVGFVGFPSVGKSTLLSKLTGTE------------SEAAEYEFTTVTVPGVIRYKGAKIQMLDLPGIIDGAKDGRGRGKQV----------IAVARTCNLLFIILDVNKP........................................................................................................................................... 155
17 -13.500[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  22  66..............................................................................................................................................RIGFVGFPSVGKSTLLSNLAGVY------------SEVAAYEFTTTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQV----------IAVARTCNLILIVLDVLKP........................................................................................................................................... 154
18 -13.100[P] COG0370 Fe2+ transport system protein B  ali follow..  17  2...........................................................................................................................................SQNTYCILGNPNTGKTSLFNALTGSYE------------YVGNWSGVTVEKKVGTL-RSKTGKLIDLPGILNPISRDETVVTRFLLEEKCMLNIVDSSQIERNLVQLLEYGAPVVMGLNMIDVAAGRGIHLNIQNLAKKLR............................................................................................................... 136
19 -13.000[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  21  64..............................................................................................................................................RVALIGFPSVGKSTLLTMLTGTH------------SEAASYEFTTTCIPGVIHYNDTKIQLLDLPGIIEGASEGKGRGRQV----------IAVAKSSDLVLMVLDASKS........................................................................................................................................... 152
20 -12.300[R] COG2229 Predicted GTPase  ali follow..  16  2...........................................................................................................................................RENKIIFTGPVGVGKTTAIAAISDEALVQTDASASDMTLDRKRNTTVAMDYGAISLDEDTKVHLYGTPGFMWEILSQGSMGLVLLLDNARTNPLKDLEFFLHSFRGLLEK.............................................................................................................................................. 116
21 -12.100[E] COG4917 Ethanolamine utilization protein  ali follow..  13  3..............................................................................................................................................RIAFVGSVGAGKTTLFNALQ----------------------GNYTLARKTQAVEFNDKGDIDTPGEYFNH--------------RWYHALITTLQDVDMLIYVHGANDP........................................................................................................................................... 77
22 -10.900[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  14  136.............................PGH-DILMATMLNGAAVMDAALLLIAGNQPQTSEHLAAIEIMKLKHILILQNKIDLVKERQAKEQYEQILAQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVGVLKVGQETEVRPGIVSKDSEGKLMCKSIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTL---CRADRMVGQILGAVGALPE................................................................................................................................................................ 366
23 -10.200[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  11  1...........................................................MAEPVSPLKHFVLAKKGI---AIFDQLLEFVTEGSHFVEATYKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSR-----RHMKVAFFGRTSSGKSSVINAMLW-----------DKVLPSGIGH-ITNCFLSVEGTDGDDLVLVDSPGT------DVTTELDSWIDKFCLD--------ADVFVLVANSESTLMNTEKHFFHKVNEWLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVANALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFFEECISQSAVKTKFEQHTIRAKQILATVKNIM. 355
24 -10.100[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  21  90.............................PGH-ETLMATMLSGAALMDGAILVIAANQPQTKEHLMALDVIGVKDVIVVQNKIDIVSKERALESYREIKEKGTCAEDAPIIPVSAQQGANIDILIETIEERIKTPKRDVDKPARMYVGRLRVGDEIEIMSLHSTITGLVAGGEEMEEVGPGGLVGVTLLDPALTKADSLSGSVAGEPGTLPPVRHSFTMETHLL....................................................................................................................................................................... 331
25 -10.000[J] COG0012 Predicted GTPase, probable translation factor  ali follow..  16  1.............................................................................................................................................MEIGVVGKPNVGKSTFFSAATLVDVEIANYP-----TTIDANVGVTYAIAEHPCKE--PVKMIDVAGLVPGAHEGRGLG----------NKFLDDLRMASALIHVVDVTGKTDAEGQPTENHDPIEDIEFLER..................................................................................................................... 136
26 -9.560[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  13  1............................................................................................................................MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAFKALEK-------IQPTVGQNVATIPVDSKQILKFWDVGG-MWSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVM.................................................................................................................................................. 119
27 -9.470[R] COG3911 Predicted ATPase  ali follow..  17  8..............................................................................................................................................VFVLTGGPGSGKTTLIAALRRAGFATSVVAGRGIVRDQSSIGGTAEMRSYQNAVEQKGPVFFDR......................................................................................................................................................................................... 87
28 -9.430[DZ] COG5019 Septin family protein  ali follow..  12  84.................................................................................................................................QWHRRCVRQGFNFNVLVLGESGSGKSTLVNTLLNRDVYPPTQKSLTGDFGVNPEPTVMINSSAVEIVENGQLNVIDTPGFVLTDIEGRYDQYLELEKHNPRSTIQDPR--VHACIFFIQPTGHAISAMELRVMLALHEKVNIIPIIAKADTLTDD----ELNFTKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAIIASNTFVVNNEGKRVR----------RRYPWGVVEVDN--EEHSDFPKLREMLI. 342
29 -9.230[R] COG2262 GTPases  ali follow..  12  86.............................PAQERNLERLCERVIDRTGLILDIFAQRARTHEGKLQVE-----------LAQLRHLATRLVRGWTHLERQKGGIGLRGPGETQLETDRRLLRNRIVQIQSRLERVEKQREQGRVSLVGYTNAGKSTLFNRITEARVYAADQ------------ATLDPTLRRIDVADVGETVLADTVGFIRHLPHDLVAAFK---------ATLQETRQATLLLHVIDAADVRVQENI-------EAVNTVLEEID................................................................................................................... 306
30 -9.220[R] KOG0410 Predicted GTP binding protein  ali follow..  11  197.............................PGQLRNLEKAFGGDVRVCDLILDIFNQRAATHEAALQVA-----------LAQMEYQLPRLTRMWTHLERQSGGQVKGMGEKQIEVDKRILRTQIVRKHRKQYRSRRVAIPVPVVSLVGYTNAGKSTLLNQLTGANV------AENRLFAT-----LDPTTRRVQMQNGKEFLLTDTVGFIQKLPTTLVAAFR---------ATLEEIAESSLLVHVVDISHPLAEQQI-------EAVEKVMSELD................................................................................................................... 418
31 -9.080[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  14  3...........................................................................................................................LFDWFYGILASLGLWQKEAKILFLGLDNAGKTTLLHMLKDERLVQHQGKIKFKAFDLGGHQIARRVWKDYYAKVDAVVYLVDA-----------YDKERFAESKRELDALLSDEALATVPFLILGNKID........................................................................................................................................... 132
32 -9.070[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  12  38...........................................................................................................................LLATIWLLSIRLFRRTKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEPNEGTFVLHNENNTKK----GKVKPVHLIDVPGKLEEYLPRAAAVVFVVDALEFLPNIRAASEYLYDILSVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAISTADI................................................................................................. 213
FFAS is supported by the NIH grant R01-GM087218-01
1 3 6 4 2 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Lesley SA, Kuhn P, Godzik A., Deacon AM, Mathews I, Kreusch A, Spraggon G, Klock HE, McMullan D, Shin T, Vincent J, Robb A, Brinen LS, Miller MD, McPhillips TM, Miller MA, Scheibe D, Canaves JM, Guda C, Jaroszewski L, Selby TL, Elsliger MA, Wooley J, Taylor SS, Hodgson KO, Wilson IA, Schultz PG, Stevens RC. Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11664-9. Epub 2002 Aug 22.