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Query: [T] KOG2492 CDK5 activator-binding protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLRQWWLRSVGSCSTVYRAHSGCSTSAAVKPKRAIPTDGLQLSDFIKESTKKQRQKAIIPSIEDTKEYLNPEDLQGNGRTVCYVTYGCQMNVSDMEIVRSIMTKYGFVESDKKENADIVLLMTCSIRDGAEKKVWNQLKLIRSNSVNKGQIVGVLGCMAERVRHDLLEKRNLVNIVAGPDSYRDLPRLVAVAAGGSNGINVQLSLDETYADVQPIRVDSASKTAFISIMRGCDNMCTYCVVPFTRGRERSRPIESIVEEVQRLRDQGYKQVTLLGQNVNSYRDMTSMDFSMAPSTSQEDRVPGFKTVYKPKSGGLTFTTLLEKVADAAPDIRFRFTSPHPKDFPMQLIELIASRPNLCKQLHLPAQSGDDETLERMERGYTRDLYLRLVDDIRHVLPSVSLTSDFIAGFCGETEQAHQNTLSLIRAVRYSFCFVFPYSMRGKTRAHHRLTDDVPEDVKARRHLDLTTVFREEALKLNQALIGSEQTVLLEGKSKRDASFSHGRIDGGVKAVFDNSKLCLEPGQYAKILITDANSQTLKAQLIGQSSILast
1 -142.000[T] KOG2492 CDK5 activator-binding protein  ali  100  1MLRQWWLRSVGSCSTVYRAHSGCSTSAAVKPKRAIPTDGLQLSDFIKESTKKQRQKAIIPSIEDTKEYLNPEDLQGNGRTVCYVTYGCQMNVSDMEIVRSIMTKYGFVESDKKENADIVLLMTCSIRDGAEKKVWNQLKLIRSNSVNKGQIVGVLGCMAERVRHDLLEKRNLVNIVAGPDSYRDLPRLVAVAAGGSNGINVQLSLDETYADVQPIRVDSASKTAFISIMRGCDNMCTYCVVPFTRGRERSRPIESIVEEVQRLRDQGYKQVTLLGQNVNSYRDMTSMDFSMAPSTSQEDRVPGFKTVYKPKSGGLTFTTLLEKVADAAPDIRFRFTSPHPKDFPMQLIELIASRPNLCKQLHLPAQSGDDETLERMERGYTRDLYLRLVDDIRHVLPSVSLTSDFIAGFCGETEQAHQNTLSLIRAVRYSFCFVFPYSMRGKTRAHHRLTDDVPEDVKARRHLDLTTVFREEALKLNQALIGSEQTVLLEGKSKRDASFSHGRIDGGVKAVFDNSKLCLEPGQYAKILITDANSQTLKAQLIGQSSI 547
2 -112.000[J] COG0621 2-methylthioadenine synthetase  ali follow..  35  2..............................................................................KKVFIRTFGCQMNEYDSDKMLAVLEHGGIEQVTQADEADIILFNTCSVREKAQEKVFSDLGRVRPKEKNPGLIIGVAGCVASQEGENIIKRAPYVDVVFGPQTLHRLPKMIVDKETSGLSQ-VDISFPEIEKFDHLPPARVEGGAAFVSIMEGCSKYCSFCVVPYTRGEEFSRPLNDVLTEIANLAQQGVKEINLLGQNVNAYRGEMD------------------------DGEICDFATLLRIVHEIPGIERMRFTTSHPREFTDSIIECYRDLPKLVSHLHLPIQSGSDRVLSAMKRGYTALEYKSIIRKLRAIRPDLCLSSDFIVGFPGETEREFEQTLKLVKDIAFDLSFVFIYSPRPGTPAA-NLPDDTPHEEKVRRLEALNEVIEAETARINQTMVGTVQRCLVEGISKKDPDQLQARTANNRVVNFTGTPDMI--NQMIDLEITEAYTFSLRGKVVE.... 441
3 -105.000[R] KOG4355 Predicted Fe-S oxidoreductase  ali follow..  22  32..............................................KDVVPKVRRRNTQKYLQEEENSPPSDSTIPGIQKIWIRTWGCSHNNSDGEYMAGQLAAYGYKITENASDADLWLLNSCTVKNPAEDHFRNSIKKAQEENK----KIVLAGCVPQAQPRQDY---LKGLSIIGVQQIDRVVEVVEETIKGHSVRLLGQKKDNGRRRLDLPKIRKNPLIEIISISTGCLNACTYCKTKHARGNLASYPIDELVDRAKQSFQEGVCEIWLTSEDTGAYGRDI----------------------------GTNLPTLLWKLEVIPEGAMLRLGMTNPPYILEHLEEMILNHPRVYAFLHIPVQSASDSVLMEMKREYCVADFKRVVDFLKEKVPGITIATDIICGFPGETDQDFQETVKLVEEYKFPSLFINQFYPRPGTPAAKM--EQVPAQVKKQRTKDLSRVFHSYSPYDH--KIGERQQVLVTEESFDS-KFYVAHNQFYEQVLVPKNPAFM--GKMVEVDIYESGKHFMKGQPVSDAKV 497
4 -77.700[C] COG1031 Uncharacterized Fe-S oxidoreductase  ali follow..  14  22..............................................................................VSPYVRYLAGALVVHDVEVDYVTIDKMRKESLWENEYDFLFVFGGITVPGRYKGGTPLTLSELRILSIARRPIKIVGGPIVLRGGSVARRFDIQADYLVSGDMEAFVVSYFQGVPDPEAKSDYELAVAPYGAVVLEKHPNFPHVICEIEVSRGCETFCSFCTEPLLHGRLKSRDVQAILKEIESLYRAGCRAFRFRAANILAFGSDR--------------------------NGGKPSPEILEELYSGPHLEVLHTDNANPSYLVTKIVETIVRYNTPGDVFSFGVESFDENVLKKNNVQGSPEEFLKAIAVVNEIIPKLLPGVNLIFGLPGETEETLKKNYSYLKRILLRRINIRKLLAYPGTPVYE-YLKNKKHRIKSYLHDQWKRRIREEIDREMLKRVFPAGTVLKKVIVEREGKTSFGRQLGSYPILVGIPG---NHSGVLDVVVVSHGERSVTALPYPSFI. 495
5 -36.000[R] COG4277 Predicted DNA-binding protein with the Helix-hairpin-helix motif  ali follow..  13  23...............................................................................................................................................................................................................................LKILLTNFCIYDCAYCINRSSSNVERARTAEEVVWLTLEFYRRNYIEGLFLSSGIIRSSDHTMEE----------------------------MVRVARELRVTHGFRGYIHLKSIPEASPRLIEEAGLYADRLSINIELPTDSGVSRFAPEKQPANIRRSMADIRLKIEERFAPAGQSTQMIVGADGADDSTILSTSRLYGSYGLRRVYYSAFSPIPDSSKNLPLIK--PPLMREHRLYQADWLYRFYGFDIGEITAIGGDGMLDLDIDPKLAWALKQRDRFPVDVNVADREMLLRFGTKTVASILSSRRFRRLR........ 325
6 -35.300[C] COG1032 Fe-S oxidoreductase  ali follow..  12  45........................................................................EPPNVNGIVKYAPYAIRK-------IEASLVRAFGREVIGVSTMDPLGLGPTTMDAWVRREWDSLMEKVNKAREGKKAKLIVGGGVWEFTILRDEIDKYKVDYYVQGETDDVVAELFRQVAEDNIDKQMFFNGYMSYDENFHKVLKKDSMKGMVEVMRGCGVGCDFCEVTLRP---RYMPLNMIVDEIKINVAGGVDNAWLHSDEIFGYKHG--------------------------EPNEEALSELFSTVMSVPGVKTSNPTHGRYPEMMEKLSKILKAGPRNWIGIQTGLETGSEELAKKHMPNKTLDIVWQGVFVETRN--YWRSAFTIQVGQEGETPEDLWETIALINKLSNSRPFEFTVTPLVNVPLGRIKSKKLNTSMLDVNGLAVYYASYRHLAKMAAR.................................................................... 493
7 -22.600[S] COG1856 Uncharacterized homolog of biotin synthetase  ali follow..  12  2....................................................................................................................................................................NVFGVIQELDVELNEKLVEKLIEGFEIRKKNFGDKVFFYSPGFKHYEVEDFSVNSPPKFVDISVTRNCELMCDHCASKILWHMIPATTPEELVKVGEDLKKKGIEGVLISGGSDKN--------------------------------GFVPLWDFFDAMKYLKEELGFLL-TCHVGLVDEDYVEKLKEA---VDAVLLDIIGDNETIAQVYKPHKSVEDYDRSLRLLKEA--GLRIVPHVIIGLHYGKIKGEYNAIDMIAKYEPDALVLVVVMPYYGKAKFQLLPPPSSEESAQ........................................................................................ 261
8 -17.800[R] COG1242 Predicted Fe-S oxidoreductase  ali follow..  13  17..............................................................................................................................................................................................................HTWNYCLREEFGQKTYKVALDGGFDCPN-CTFCSAAGSGDFAGNRDLKVQFQQVRDKMQTKWKKCIAYFQAFTNTHAPVA-----------------------------ELREKFETVLNEPGVVGLSIAT-RPDCLPDDVVEYLAELNE-YLWLELGLQSAHDETGRLINRAHDYDCYLEGVRKLQKH--NIRICTHIINGLPKETPEMMMETAQKVVESGVDGIKIHLLHLLKGTPMVEDYKGDLEFLTRDGYVNLVADQLEILPPEMVIHRITGDGDDLIGPVWSLNKFEVLNAIDAE........................................ 301
9 -17.600[R] COG2516 Biotin synthase-related enzyme  ali follow..  12  31.................................................................................................................................................................................................................................TYYEGRCINDCKFCAQARSSRANLEMPAFELETVLKNFSKGNFKRICLQTIDYPNMLSDV--------------------------------FSLLEELSKLNVPISLSITPVPRSELEE--------STLGVDYIGVGLDAASERVYKDVKSRYSWDDMWKFFDDVLSVFGKGRAVVHLIVGL-GETDKEIVETIGEVYKKG-GIVSLFAFTPIKGTQMENFSPPPLERYRKIQVAHYLIKTGEAELEDFEFDEFGNLIGL............................................................ 258
10 -17.000[H] COG0320 Lipoate synthase  ali follow..  13  10.............................................................................................................................................................GVKYRDADKMALIPVKNVVTERQELLRKPEWLKIKLPTDSSRIQGIKAAMRKNGLHSVCEEANHGTATFMILGACTRRCPFCDV--AHGRPVTPDANEPEKLAQTIQDMGLRYVVITSVDRDD----------------------------LRDGGAQHFADCISAIRAKNPTIKIETLVPDFRGRMDRALDILTATPPDVFNHNL---ENVPRVYRQVRPGANYDWSLKLLERFKEAHPDIPTKSGLMVGL-GETNAEIVEVMHDLRRHGVTMLTLGQYLQPSRHHL------PVQRYVSPAEFDEMKAEAMAMGFT........................................................................ 297
11 -16.000[KB] COG1243 Histone acetyltransferase  ali follow..  9  17.............................................................................................................................................................................................................................VSIMTHPH-SCHGKCVFCPGGVDVDTPQSDPFHQVQSRLRQYVENGHTELIIMGGTFLSLPIDYQDW------VTYALEAMNRFPSYDKPSFVYLEDAQVKNEKAEVRCVGMTIET-KPDWAKEWHADQMLRLG--ATKVELGVQTVYDDILKFTNRGHTVKDSIESTRILKDS--GFKVVYHVMLGLPKSDPDKDLEAFKTIPNFRPDMLKIYPTLVVETAPLANLWRRGLYKPYGTETLIELISEMYRYIPK........................................................................ 283
12 -15.000[BK] KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase  ali follow..  9  8........................................................................................GVGLSRQERQVLVIGEIIQELLKAHEAKKDVNLNRMKSLVASKYGLDSSPRLVDIIAAVPQDAKKILLPKLRAKPIRTASGIAVVAVMCKPHRCPHIN---------------------------------------------TGNICVYC----------GGPDSDFEYSTQSYTGYEPTSMRAIRSRYDPFLQTRHRVEQLKQLGHSVDKVEGTFMCLPEEYRDYFIRNLHDALSGHSSANVAE-IETRPDYCLKRHISDMLSYG--CTRLEIGVQSVYEDVARDTNRGHTVRAVCESFQLGKDA--GYKIVTHMMPDLPNVDFERDIEQFIEYPAFRSDGLKIYPTLVIRGTGLYELWKTGRYKSYPPSMLVDLVAKILALVPP........................................................................ 360
13 -14.600[R] COG1244 Predicted Fe-S oxidoreductase  ali follow..  9  25......................................................................................................................................................................................................................................GCYRYCYMCSYPAQAPKKTSQELSHFLEAVHKIKGKDDRFSIRIFTSGSFFDSAEVRRD--------------------------TRIRIFREISKLDNVYEVVVET-RSEIIREDWVRELAEVEDKWFEVAIGLESANDDIADVINKGSTFNDFVRASEIIHNA--GAKVKTYLLLKPIFLSERDIEDVKFSIEKAEPDTFSINLTNIQKGTLYESLWQRG---EYRTPWLWSVVEVLRWAKKKFPHKRF.................................................................. 255
14 -13.900[H] COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases  ali follow..  13  4........................................................................................................................................................................................................................NRLPPLSLYIHI---CVQKCPYCSHAQKGHIPEQDYIAHLLQDLHSIQDRSLHSIFIGGGTPSLFSAE-------------------------------GIHTLLSGVAQCLPFQ----LEANPGTAEAERFKGYVQA---VTRISMGIQSFNDDKLVRLGRIHNAQEAKSAVGFAKLS----SFNLDLMHGLPNQTLEEALSDLQQAIALEPPHLSWYQLTIEPNTMFAYRPPVLPDDDALWDIFEQGHQLLTEAGYVQYE..................................................................... 243
15 -13.400[H] KOG2672 Lipoate synthase  ali follow..  16  119............................................................................................................................................................................................................................RATATIMLMGDCTRGCRFCSVK-TSRRPGPLDPNEPENTAEAIKQWNLGYIVLTSVDRDD----------------------------LTDLGANHIAKTIQKIKEKAPHILVEALTPDFSGRMDLVEIVAKSGLDVFAH----VETVEELTPFVRDRRATYRQSLSVLKHVKKTCPHLITKTSIMLGL-GETDAEILTTLKDLLEHNVDVVTFGQYMRPTKRHL------KVQEYVHPKKFEYWKEVAEKLGFL........................................................................ 335
16 -12.300[H] COG0502 Biotin synthase and related enzymes  ali follow..  10  66.......................................................................................................................................................................................................................................CPEDCSYCPQSARYHTGVQNDVDEIVAKAKIAKARGAGRFCMGAAWRGPKPKD--------------------------------IEKVTEIIKAVKSLGLETCGTF---LLQDGMAEDLKEA-----------LDTAPEHYAEVIGTRRFDDRLSTLGKVRKA--GLKVCCGGIVGM-NETRKERAGLIASLANLD-ESVPINQLVKVEGTPLADAEELDWTEFVRTIAVARITMPKSYVRLSAGRSGMTEEMQAMC.......................................................... 289
17 -11.700[HR] COG1060 Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes  ali follow..  15  54..............................................................................................................................................................................................................................DTNINYTNICLSKCRFCAF-YAREKGYVLSHEEILRKVGYAVKMGATQIMLQGGMNPDLGLE-------------------------------WFEELFRKIKARFSSVHIHSLSPP---SIREVLDRLKAA-GLDSLPGGGAEILVDSVRRKI-NKCSSDEWLRVMETAHSL--NMPTTATMMFGH-VESDGDIVEHLIKIRELQEKTGGFTAFIPWTFQPGNTELYAEIKRPVSPLRYLQVLAISR............................................................................. 274
18 -11.200[H] KOG2900 Biotin synthase  ali follow..  10  69.......................................................................................................................................................................................................................................CTEDCKYCAQSSRYNTGVKAKIDEVLEKAKIAKAKGSTRFCMGSAWRDLNGRNRTFKN---------------------------ILEIIKEVRSMD-------VCVTLGMLNEQQAKELKDA-----------LDTSREYYSKIISTRTYDERLNTIDNLRKA--GLKVCSGGILGLGEKKHDRVGLIHSLTMPTHPESVPFNLLVPIPGTPVGDAVKERLPPFLRSIATARICMPKTIIRFAAGRNTCSESEQALA.......................................................... 296
19 -10.900[R] COG2100 Predicted Fe-S oxidoreductase  ali follow..  9  1.....................................................................................................MIKLRLPNSYFEGHEDTITLV---------RTLVADFSKREIERAIRRKFRVSVEVNVEDGYLVINTDNEDIERFIAFYIQNNLGGLLKNRYTKRKVIYIHEGMGVPLLGYNAFGLIDRGTNLIVRGSTGCNMRCIFCSVDEGPYSRTRKYLLKWFDWVAKEKGKGLEAHLDAQ------GEPLLYP---------------------------FIVELVQALREHPHVSVISMQSN----LNDKLVEELAEA---LDRVNLSIHSLDPEKAKMLIKDYDLNHVLEMAEALVNAGIDVLIAPVIMFGV---NDDEAEAFIEFARRKRWPALGFQNYIPIAKPVPFKEFYRWLRELEEKTGMKPLILKPHHFGMYPRPFIRGEVVKAEVILPGR--EGEMIAKARNRLIQVINSNAK---VGDRIKVKIVRTRHGIYVGTPV..... 419
20 -10.200[R] COG5014 Predicted Fe-S oxidoreductase  ali follow..  12  79.................................................................................................................................................................................................................................TADTVGCKFLCAYCRNLRPKRAGDFLSPEEVAERLLEISKKKCDLFRISGAEPILG---------------------------------RRSAEHVRKVIELVNNTFILETNGLMFGFDPSLVDLFVN---LNVLIRVSVKGWDEESFEKIT-GASGEYFRYQLKALEHLHGKVHFWVAVVYDLFREKGKELEKRLPIPCRIEKEYLEMY................................................................................................................ 257
21 -10.200[R] COG2108 Uncharacterized conserved protein related to pyruvate formate-lyase activating enzyme  ali follow..  10  35...........................................................................................................................................................................................................................RGEKLVLFVTGVCPRNCFYCPLSPWRRKDVERPVRSEKDIIEEAKIQDARGAGITG------GDPLARLS--------------------------RTVEYIRLLKEEFGKKFHIHLYTTGILASEEALEKLYDAG--LDEIRFHPDLFQ-------PNSKFFEREIENMKKAFDFGWDVGGEVPAV-----GFEDRIKWFASLLDKLGAKFLNINELEF---SETNLRALLDRGYKPVSDESSAIKGSLEMGLKVLEWGEKNTSLNYHLCTAKLKDAVQLRNRLKRMAKNVARPYMEITEDGTLRFGIAEYDDLEELYEFLVEEAEV 318
22 -9.950[R] COG1964 Predicted Fe-S oxidoreductases  ali follow..  13  1..........................................................................................................MQNVESELKDIRLPYKTKSLCPECLKILEAEV-------EENGKVMIRKVCEEHGEFVDVYWG--------DAEMFKKAARFAADGHGISTPITQNTT---PFSCGLCNNHKSHTALLNIVLTNRCDLACWYCFFYARRAGYVYEPIREMVRKAKNMKPIGCNAVQLTG------GEPTLRD---------------------------DLIDIIRMIKE-EGYDHIQLNTAEDPDFALRVRVA-------VNTVYLSFDGVDEKTNPKN-----HHEIPKILENCRRAQLGLVLVPTVIKGV---NDHQLGDIIRFVRGVNFQPVSLVGSMPRKEREQFRITIPDCIKAIEEQ....................................................................................... 306
23 -9.710[R] COG0535 Predicted Fe-S oxidoreductases  ali follow..  9  6..........................................................................................................................................................................................................................RGPTHVDFNLTNGCNLACSHCHSASGPKLDNELKTEEILQTIDALHIIGALKIAFAG------GEPFIRR---------------------------DIFNILSHACSLPGWG----VITNGFYLNSLTVEKLKAQCPN-LSINISVDGSTPAGYSTLRKQLNRPDFERVLSGID-NVVRSGMSNSVNFTITKATLHDIEATYELVVDRIGADNMVAIKFFPGGYGKEHLDLYEIPYDMWDEHFVALTRAKLGGKLERLQISVPAAWEFYLPLINAGIPIEEAEEVWGYRSPLREDMYARMREGEVYPSVLLVGEKTMSCGNLREHS.. 316
24 -9.500[E] COG1509 Lysine 2,3-aminomutase  ali follow..  8  118..............................................................................................................................................................................................................................KVLLLATDRCPVYCRFCTVLKKKVSPFQSRWDTILAYLRV--TPVIADVVVSGGDCFRLKPS-------------------------------RLLAIGMGLLSIPSIRRIRFATK-PMKITSDLVNISDAGRDQGVEISFHTHFNHPREI--------TDYTIAAAELLFKRGIRMRNQSVLMAGV-NDDPEVMKQLVKKLSDLHIQPYYVYTCDLVDGI-EHMRCSVRLACQIEKAVRGITAGYNTPLFVVDTPGGGGKRDVHSFEHYNTQTGLAVY.............................................. 374
25 -9.300[H] COG2896 Molybdenum cofactor biosynthesis enzyme  ali follow..  11  29.................................................................................................................................................................................................................................VSVTDRCDFRCTYCMAEHMTFLPKKDTLEELDRLCSVFIEKGVRKLRLTG------GEPL-------------------------RKNIMHLIGNLSRHLKSGALDELTLTTN----QLARFAGELADC---VRRINVSLDTLNPEKFRTITRWGDLSRVLEGIDAAQKAGIHVKINAVALKDF---NDAEIPELIRWAHGRGMDVTLI................................................................................................................. 202
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Rychlewski L, Zhang B, Godzik A. Functional insights from structural predictions: analysis of the Escherichia coli genome. Protein Sci. 1999 Mar;8(3):614-24.