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Query: [R] KOG2552 Major facilitator superfamily permease - Cdc91p, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MKEEKKDDGVMAEEKPYMFWIWTLASTIFRLFLIFSPANINLSSRPEVSTPHTSLRRLAEGYWLKQSSLSPYAGSMYHGSPLLLSILGPLTVQSDKFVVAGSKGNRVIICADLLSALLLRAIGQKLQKSYRMNLRPLGVLRSSQDRGILPCGDIAALVYLWNPFTILSCVGLSTSPIENLAVIVSLYGAVTRRVPLAAFGLIMATHLSLYSAPLVFPLIFLLGYGLDAPPIKKFLQTRHGGVETGSTSDVSKQEKLTPTTQLPFSWRTVLHFVFWVLVWSSYVLVLCSLSLKQYGGLEEMFKRTYGFILRIEDLSPNIGVFWYFFAEAFEFSRNYLLIIFNLYILLTSIPSLMFRLKHRPCFLAFAYLAFTSILKSYPSVGDAALYLSLWALFVNELTDMEYSFFIFCGYIGFSLLSPVMHNFWIWRGTGNANFYFGNAMGYACFQFMFVEKSVNAMLNHDQALKKATAEMTKNLast
1 -136.000[R] KOG2552 Major facilitator superfamily permease - Cdc91p  ali  100  1MKEEKKDDGVMAEEKPYMFWIWTLASTIFRLFLIFSPANINLSSRPEVSTPHTSLRRLAEGYWLKQSSLSPYAGSMYHGSPLLLSILGPLTVQSDKFVVAGSKGNRVIICADLLSALLLRAIGQKLQKSYRMNLRPLGVLRSSQDRGILPCGDIAALVYLWNPFTILSCVGLSTSPIENLAVIVSLYGAVTRRVPLAAFGLIMATHLSLYSAPLVFPLIFLLGYGLDAPPIKKFLQTRHGGVETGSTSDVSKQEKLTPTTQLPFSWRTVLHFVFWVLVWSSYVLVLCSLSLKQYGGLEEMFKRTYGFILRIEDLSPNIGVFWYFFAEAFEFSRNYLLIIFNLYILLTSIPSLMFRLKHRPCFLAFAYLAFTSILKSYPSVGDAALYLSLWALFVNELTDMEYSFFIFCGYIGFSLLSPVMHNFWIWRGTGNANFYFGNAMGYACFQFMFVEKSVNAMLNHDQALKKATAEMTKN 474
2 -66.400[G] KOG3893 Mannosyltransferase  ali follow..  14  419..TKLRESSLYLLYAPTDAFLLLLLGLLMRLVLLNYG--IWHDRRSALKFTDIDYFVFSDASKYVSIGMSPYMRDTYRYTPMLAILLLPTQYGFP------SWGKYLFSISDLIAGWLMIKLLSRRISYK--------------------RSLIYSSFWILNPFVAIISTRGNCEAILGILSIALLYLIEKKSVWLASLILGFSVHFKIYPFMYGIAFLVYFSKPK-------------------------------KGSTFMEKFLSLLSINQLKIVVGSLFMFTICNLLMYYLYGSPFLEHTYLYHFGRTDHRHNFSLHHLNLYYESSFGAKASSLFAFLPQLSLCMLIPLVFGKKNLPGTLFAQTFAFVTFNKVCTSQYFMWYLVFLPLVLPNSKLSKKGLICLSLWIIGQLLWLISAYNLEMLGKSVFIPLWLSGLLFFFFNVYELKIILDSL................. 815
3 -25.500[S] COG5650 Predicted integral membrane protein  ali follow..  8  29IGGRFGRFAQVGTQRFWTPLRVLITTSLVFLAMGFLTKANCIRQYTSACYNDIVPLYGGRGIDYAFSWQEGDLTRYMEYPVLGGIFQWICGIITRVIPFHTLPESGLYFIVTALALAFFWVLVIRMMVELTGNRV-------------------WDTVLVAASPLVAVHAFTNWDTPAIAAVIGAMLAVKRGNPLVAGVLIGAGTAFKLWPLYLLGAYLVLAVKNKNLKP-------------------------------------------FITMAAAAAVTWLVVNVPVMIAYPKAWNEF---LRLNRERGAEWTTIYQVIDRNLNDPVLLNVLSFGLFGASCVAILILGLKVQRTPRVLAFLIVAAFLLFNKVWSPQYSLWLVPLAVLAFP-----QWKVLFPWMVTDAMVWPILMWHMLGTDNKGPHEMLDLIVISRDAFIVVMIVGVIRQMLGRRAD........... 457
4 -13.200[S] COG5542 Predicted integral membrane protein  ali follow..  9  15.SNSYLAIRMTRSGYNYFKGICVCTFLLSTILYLGIAVIMSHLCVFDDTAMLYLRQNRSDAIYFVDMAVNGSL-QEWAFSSLWPKIISFLAFRSKDVVLLGIVSCFASIFFHAIACYALYLLTKSIFSNQK-------------------MTAYTVIFYCFSPSGIYMSVGYT-ESLFAAFSFLGLLLFIKKQQYPAAFLWSLATLIRSNGIFWCIFFGMPA-------------------------------IGTLKISLERLQLTFMQVSQLVGYGTKCLIILVPFFYNQYLGFKYPAVQEKY-----------NVGFLRYWTLNNIPNFLFALLSIIPILFALFYSISGSTLHSFRSIKSHLVLSALYLYIRMSSALPLLYWSMAHATLYAKSRNLKAFGHCILFVWIVYTVIQAGLY----------GSFL....................................... 423
5 -13.000[O] COG4346 Predicted membrane-bound dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  13  171..............................................................................HPFLGKDIIALGMLIEDKPFYWRIPGIIEHALIVIIVTLVAYKITKS-----------------------YLASSIAATFAALDPLLFATGIVAMLDIHVAFFIALFMLFLALDRIRLSGIALGLAAATKLSGAFAFPILWFKILKEK--------------------------------------DLKEYLISGLVLPMVSFLIPEITIIKAIGFIPWLEEFIASFSWHLSFKGEHPSEAPFWFHFDPDVYAVTDPILMISMIVFVFAVP-YVSLRRKGLSEIFWMFWSIIAFFALQYILGGKTQFIFYATPLIP----------------PGAVALGVISYEIIKWEYFERSLRIYLNYLR-------SIAKPLKKVIKR.............. 477
6 -12.600[O] COG4745 Predicted membrane-bound mannosyltransferase  ali follow..  10  1...MRRSRDDSSPRVAAAVVAVTAAALLARLW---------LGWRVEARVADWTLQYMDLGA---------WQYRPIIHGPFLPHVNGVVFDVFGATDFTMRLVVAVVGGLLPLTAWLYRTRL-------------------------DVEVGALAVLLAANPVVLYYSRFMRNDLLLAGFMFTAVGLFVRRYLYASAVPFALAFTTKLYPLCWLGALALVTDDRMAVAGATDTSRLAVVRRAAARIRHRAWRAKAALAGSALTAAVIVVSFYAPKPDLYRLFEQPGRAPAVLEAATIGTYHEFADLWASTSTVAHSYVAFLSHDLSVLVACGTVVSVA-----AVVGYLANRYATETPRPLVSFAFYWGVFSVLGYPAVVDIAAAWTAVNALVPL------------AIPAAVGVGAVVRYGRRGAAAGDTAAVRLAVTVLVVSAAGMGAVAAETTYAH.............. 414
7 -11.200[R] KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase  ali follow..  10  1MAKALESNSKSRKETILIKYAIFSRLLVLFLTILWRSLLQPYDTSAALNPPCLYHKEDSDSVYFLRITECGYEYE-LPLLPFFISLLSRTVFLIGLRAVMVLSGFTVSNLAFIFAAIYLFRVSVIILKDTE-------------------ASFRASIIFCFNPASIFYSSIYS-ESLYALFSIGGVYHLLSGTSNVGVLWFALSGCARSNGILNAGYICFQTMHRA-----------------------------------YEALYQKRRAYLAMQVFIAGFLRCICICLPFVAFQAYGYIPLLYNFIQKILVSDRGVGFLKYFQFKQLPNF------LLASPILSLAVCSIMSYMKSRPELFISLSSKKDVTGTKVAPEKSGYLSADVFPFIVHLSFMVTTAFFIMHVQVATRFLSASPPLYWFASHSKWGYLIWSYCAAYILLGTLLFSNFY.................... 489
8 -9.960[O] KOG2292 Oligosaccharyltransferase, STT3 subunit  ali follow..  9  1MNRTPKMLNSKVAGYSS-LLIAWLAGFSSRLF---------VIRFESIIHEFDPWFNYRATAYMVQNGWYNF--DERAWYPITSGGIHWLLHVLNIPVHIRDICVFLAPIFSGLTSISTYLLTKELWSAG--------------------AGLFAASFIAIVPGYISRSVAGDNEGIAIFALQFTYFLWVRSWSAAAALSYFYMVYVFIINLIPLHVFVLLIMGRYSPRLLTSYSTFYILG------------LLFSMQIPFVGFQPIRTSEHMAALGVFVLLMAVATLRHLQSVLSRNEFRKLFIVGGLLVGVGVFVAVVVLTMLGVVAPWSGRFYSLWDTGYAKIHIPIIASVSEHQP-----------TTWFSFFFDLHILVCAFPVGVWYCIKQINDERVFVVLYAISAVYFA-----------GVMVRLMLTLTPVVCMLAGVAFSGLLDVFLQEDSSKRMGTAISAAT 447
9 -9.720[GE] KOG2575 Glucosyltransferase - Alg6p  ali follow..  11  33.........LTHKGTTTSFLCISLFALLIRSAVTMYPYSPPKFGDFEAQ----HWMEITTNLPVID-----YRNGTLDYPPLTAYQVALLSSRGHESYLGKLLMRWTVLSSDAFIFFPAALFFVLVYHRNRTRGGKSEV-------------AWHIAMILLNPLILIDHGHFQYNCISLGLTVGAIAAVLCESEVLTCVLFSLALSHKQMSAYFAPAFFSHLLGKCLRRKSPILSVIKLGIAVIVTFVIFWWPYVHSLDDFLMVLSRLAPFERGIYEDYVANFWCTTSILIKWKNLFTTQSLKSISLAATILASLPSMVQQILFLYGLLNSSMAFYLFSFQVHILMPFLSATLLALKLPDHFSHLTYYALFSMFPLLCRDKLLIPYLTLSFLF................................................................................. 433
10 -9.160[G] KOG2762 Mannosyltransferase  ali follow..  8  49....................LLILFESMLCKIIIK-----------KVAYTEIDYKAMEQIEMIQLDGMLDYSQVSGGTGPLVVLIYKMMYWLTEG--DHVERGQVFFRYLYLLTLALQMACYYLLHLPPWCVVLACLSKRLHS----------IYVLRLFNDCFTTLFMVVTVLGAIVASRCHQRPKLKKSLALVISATYSMAVSIKMNALLYFPAMMISL-----------------------------------------FILNDANVILTLLDLVAMIAWQVAVAVPFLRSFPQQYLHCAFNF----RKFMYQWSINWQMMDEEAFNDKRFHLALLISHLIALTTLFVTRYPRKTIPFVLIASNFIGVLFSRSLHYQFLSWYHWTLPILI---------FWSGMPFFVGPIWYVLHEWCW--------NSY-QASTLLLALNTVLLLLLALTQLSGSVALAKSHLRTTSS 452
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.