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Query: [S] KOG2632 Rhomboid family proteins, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRPNIVTEAGVQTRVGQWWNAIPFLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSAIISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIMGSVRLLYLTVLLATTNAVLHLLIASLAGYNPFYQYDHLMNECAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVPAKLYPWILLIVFQLLMTNVSLLGHLCGILSGFSYSYGLFNFLMPGSSFFTTIESASWMLIVTHPVSMSSSSLASLGDPSSLCVLAGILPAIFPLILHKTQHPGNAWRSLSSWLPQREASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGFDRTQVEVALAAADDDLTVAVEILMSQQVLast
1 -131.000[S] KOG2632 Rhomboid family proteins  ali  100  1MRPNIVTEAGVQTRVGQWWNAIPFLTSSVVVVCGVIYLICLLTGYDTFYEVCFLPSAIISRFQVYRFYTAIIFHGSLLHVLFNMMALVPMGSELERIMGSVRLLYLTVLLATTNAVLHLLIASLAGYNPFYQYDHLMNECAIGFSGILFSMIVIETSLSGVTSRSVFGLFNVPAKLYPWILLIVFQLLMTNVSLLGHLCGILSGFSYSYGLFNFLMPGSSFFTTIESASWMLIVTHPVSMSSSSLASLGDPSSLCVLAGILPAIFPLILHKTQHPGNAWRSLSSWLPQREASNQSSEDSRFPGRGRTLSTARDPTAPAGETDPNLHARLLEDSSSPDRLSDATVNTVADSRQAPIANAAVLPQSQGRVAASEEQIQKLVAMGFDRTQVEVALAAADDDLTVAVEILMSQQV 411
2 -65.600[S] KOG4463 Uncharacterized conserved protein  ali follow..  13  8..................PSNMG-ITKFLLLTISTSSVVAGVFALKPFFHINFGLH-LLSHYQYWRILLWQFIYWNSTEVFQALFIIYQAR-DVERLLGSHRFASFCVYMFILGMFVTPIFSFLYSLLF-----KNLDYIQPGPTFLIFAILYQYYYIVPSTVFVRLFNIKFTDKFQMVIPMIGLAFSHFPSTFINAFLGWTMGMFYHLSLLTSWRLPIRFVKPALSPTHVFI------------------------RPPYSDMQNASTFNPETLFALPTGLDAERTENENQVENPVSNADANDSPTRQNARATAIASSSNTAASFRNRQQISHPPLGRTSSSSVLPTGPASQLYDMLSGRSERPELGNIREEDINTVQTMQTSRAQAIQALS-QTNDVQRAVELLLEQT. 369
3 -48.000[R] COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)  ali follow..  21  91...................ERAGPVTWIVMLACVLVYIAMSLIGDQTVMVWLAWPFDPVLKFEVWRYFTHIFMHFSLMHILFNLLWWWYLGGAVEKRLGSGKLIVITVISALLSGYVQQKFS---------------GPWFGGLSGVVYALMGYVWLRGERDPQSIYLQRGLIIFALLWIVAGWFDWFGMSMANGAHIAGLIVGLAMAF.......................................................................................................................................................................................................... 266
4 -43.900[T] KOG2980 Integral membrane protease of the rhomboid family involved in different forms of regulated intramembrane proteolysis  ali follow..  16  143......................KNLVYALLGINVAVFGLWQLPKCWRFLQKYMLLQKDY-VTSKISIIGSAFSHQEFWHLGMNMLALWSFGTSLATMLGASNFFSLYMNSAIAGSLFSLWYPKLARLA--------IVGPSLGASGALFGVLGCFSYLFPHAKILLFVFVPGGAWVAFLASVAWNAAGCGSFDYAAHLGGSMMGVLYGW.......................................................................................................................................................................................................... 325
5 -41.500[S] KOG2890 Predicted membrane protein  ali follow..  12  3VKAVLGDLQIVVERHSDVLRNNALPFRFLVVLRIIGYIISYL---HFARLLLWLHPYQIASIELWRIATSTFCGHNVLDVLWTVWCLHFGTNLVRLNNTNESLLKLYAITQGVTTFVIVVFA-YLTYILFDSIKFFYIEPLVGMTPICASVMVLMKQFLPDTIVLATPLGRIKYAHLPFLAIFVSFILAYFVSFLQITIGVQVSWTY----LRFYKPHETDEIYGDGSEHFTWASLFPSRTQLFFTLIGKVCFRTLARMGVCKRQVRHVDLHSLQSGSVGINLPALENSAKDSERRRQKALKELNDRLNKTRTAEVASYGNWDDGDDDEPTEVTVVAPPPVSNVHSSKPAMDKESMA...................................................... 356
6 -39.600[T] KOG2289 Rhomboid family proteins  ali follow..  18  58...................KKITGPNKECVARFLGRFSFQPLKESSTLEKMGALERKVVHEHQGWRLLSCMWLHAGIIHLLTNMLSLIFIGIRLEQQFGFIRVGLIYLISGLGGSILSSLFLQ--------------ESISVGASGALFGLLGAMLSELLTNWTIYANKAAALITLLFIIAINLALGMLPRVDNFAHIGGFLTGFCLGFVLL....................................................................................................................................................................................................... 244
7 -33.400[S] COG5291 Predicted membrane protein  ali follow..  11  1MPSIPQMNNT---FLLGQMLRVPPITRYMTLLISAVALLVYVDAVSPYS---YYSPLFLKRLEIWRVFTSFLYFGKPLDMFMHVVFLYRYSRMLEEGCVNTSEYFWLILVISSVLFAISNIYGISAL----------------GTSFSATITYIWTKRNPRAIVQIFGFISFPAFYLPFIL-PGFMLLSRRSISIDDVLGIVVGHLFHY------------FKDVYPRWGRDILSTPCWVKKLFNEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGD---------------------SDNESECS......... 348
8 -32.600[T] KOG2290 Rhomboid family proteins  ali follow..  15  603..................TKGRCEITSREYCDFMRGYFHEEATLCSQVHCMLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLP--------------YRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGK................................................................................................................................................................................................ 794
9 -24.900[S] KOG0858 Predicted membrane protein  ali follow..  16  1............MDAGVWYRSLPRFTRYWLTATVVLSMLCRF-DVIPLHWLHLDRSAVFSKLQLWRCMTSLFVFPISSNTAFHFLINCFFIVQYSSKLEKDQYS--YLYLLIVSAVLANIGGMIFNVYFL-------------MDTLVLAITYIWCQLNKDVTVSFWFGTRFKAMYLPWVLAAFEFIFHFSLA---SLVGIFVGHVYYFF----------------------------------------KFQYSQDLGGTPLLETPQFLKRLVPDVSGGFGGFGLPPESRAPPRQATESPWGRGMTLGRN.................................................................................................... 245
10 -19.600[OR] KOG0010 Ubiquitin-like protein  ali follow..  20  467..................................................................................................................................................................................................................................................................................................QQGLQTLATEAPGLIPGFTPGLGALGSTGGSSGTNGSNATPSENTSPTAGTTEPGHQQFIQQMLQALAGVNPQLQNPEVRFQQQLEQLSAMGFNREANLQALIATGGDINAAIERLLGSQ. 587
11 -15.500[L] KOG0012 DNA damage inducible protein  ali follow..  16  371...........................................................................................................................................................................................................................................................................................................................................GNSEDSMEQEAISNAIEQSKRESGGAGGGPNTISPQERFTEQDVTDLMALGYPRSDVLTVLRLCGGNKQAARSVLLHRN. 449
12 -14.200[L] KOG0011 Nucleotide excision repair factor NEF2, RAD23 component  ali follow..  20  285...............................................................................................................................................................................................................................................................................................................................................NEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQN. 359
13 -12.700[OT] KOG2561 Adaptor protein NUB1, contains UBA domain  ali follow..  9  393...............................................................................................................................................................................................................................................................................................ERISEERKNSAAERQVNQEMIFAGQGGEWVNPRSIIRLMEMGYERRLVVEALKRTKNNLDRSLDLLQRHSDELRANLPPIPPVDESLLTTLQHLGFSEISARDALETTGNSFHKSLKFLLKSF. 515
14 -11.800[R] KOG3450 Huntingtin interacting protein HYPK  ali follow..  11  2.................................................................................................................................................................................................................................................................................................ATEGDVELELETETSGPERPPEKPRKHDSGAADLERVTDYAEEKEIQSSNLETAMSVIGDRRSREQKAKQEREKELAKVTIKKEDLELIMEMEISRAAAERSLREHMGNVVEALIALTN... 121
15 -11.300[O] KOG2689 Predicted ubiquitin regulatory protein  ali follow..  34  2....................................................................................................................................................................................................................................................................................................................................................................................SEVQTLMDMGFPRERVEYALEVTNKGVEPAMEWLLAHV. 40
16 -10.900[K] COG1308 Transcription factor homologous to NACalpha-BTF3  ali follow..  17  63.................................................................................................................................................................................................................................................................................................................................................................TMREVPKEPEEKKEESFPEDDIKLVMEQSVSREKAIEALKASGGEPAQAIMNLMQK.. 119
17 -10.800[O] KOG4588 Predicted ubiquitin-conjugating enzyme  ali follow..  17  1....................................................................................................................................................................................................................................................................................................................................MTSLFRRSSSGSGGGGTAGARGGGGGTAAPQELNNSRPARQVRRLEFNQAMDDFKTM-FDYDIIECVLRANSGAVDATIDQLLQMN. 88
18 -10.400[S] KOG4791 Uncharacterized conserved protein  ali follow..  12  639................................................................................................................................................................................................................................................QTLEKRGEAKPTVNVKQSVVKVVSSPKLAPKRKAVEMHPAVTAAVKPLSSSSVLQEPPAK-AVDAVVLLDSEDKSVTVPEAENPRDSLVLPPTQSSSDSSPPEVSGPSSSQMSMKTRRLSSASTGKPPLSVEDDFEKLTEISGGKLEAEIDLDPGKDD-----DLPLE... 804
19 -10.100[K] KOG2239 Transcription factor containing NAC and TS-N domains  ali follow..  11  245.........................................................................................................................................................................................................................................................................................................................STTSVASQAAVKAAERFRGTSPAGRQGNEDGKAPGEESPHDDDDDENDGEDADAMGLHAKDIELVQMQACSRKKAIQALLKNDNDVVNAIALTVG... 341
20 -9.580[S] COG5395 Predicted membrane protein  ali follow..  12  1MDPHGKSISQASDRWSGLRNAALGVGAATLIVALTAPGAFTDLGAFAQQVRFQPHAPDFSRIAAAPAVVQVHLFSALTALAIGVVLMM--GTTLHKLLGW-----TWVLAMGSTAVSSLFIREI----------NHGAFSFIHLLSGWTIIGLPGAVYAIKRGKVSAHRKAMTGMFVGGLLVAGVFTFLPG------LWTVFLG............................................................................................................................................................................................................... 186
21 -9.460[S] KOG4351 Uncharacterized conserved protein  ali follow..  12  502...............................................................................................................................................................................................................................................................SQTLETVPLIPEVVELPPSLPRSSPCVHHHGSPGVDLPVTIPEVSSVPDQIRGEPRGSSGLVNSRQKSYDHSRHHHGSSIAGGLVKGALSVAASAYKALFAGPPVTAQPIISEDQTAALMAHLFEMGFDRQLNLRLLKKHNYNILQVVTELLQLN. 657
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 1 9   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Ye Y, Godzik A. Multiple flexible structure alignment using partial order graphs. Bioinformatics. 2005 Mar 3;