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Query: [DZU] KOG2655 Septin family protein (P-loop GTPase), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MADTKGFSSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRRNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENPDHCDFIKLRTMLITHMQDLQEVTQEVHYENYRSDRLAKGIKGKENGVKAERDSSSQVVSNSVLGEKDRILQEKEAELRRMQEMLAQMQARMQAQQLast
1 -118.000[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali  100  1MADTKGFSSIETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLVNSLFLTDLYPERIIPDAIEKQKQTVKLEASTVEIEERGVKLRLTVVDTPGFGDAIDNSNSFGAILEYIDEQYERFLRDESGLNRRNIVDNRIHCCFYFISPFGHGLKPLDVEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESHGIKIYPLPDCDSDEDEDYKEQVKQLKEAVPFAVCGANTLLEVKGKKVRGRLYPWGVVEVENPDHCDFIKLRTMLITHMQDLQEVTQEVHYENYRSDRLAKGIKGKENGVKAERDSSSQVVSNSVLGEKDRILQEKEAELRRMQEMLAQMQARMQAQQ 361
2 -106.000[DZ] COG5019 Septin family protein  ali follow..  37  62.NPHVSIIQRQLNGYVGFASLPNQWHRRCVRQGFNFNVLVLGESGSGKSTLVNTLLNRDVYPPTQKGDFGVNPEPTVMINSSAVEIVENGISLQLNVIDTPGFGDFIDNTDCWQPVLTDIEGRYDQYLELEKHNPRSTIQDPRVHACIFFIQPTGHAISAMELRVMLALHEKVNIIPIIAKADTLTDDELNFTKEMILRDIQYHNIRIFFPPTYETDDPESVAENADIMSRIPFAIIASNTFVVNNEGKRVRGRRYPWGVVEVDNEEHSDFPKLREMLITHLEELKEQTNK-LYEAYRTERLLSSGISQDHSVFREVNPSAKLHEEKLMKMEAEMKTIFSQKVQEKEDRLKQSENELRTRH 430
3 -94.200[D] KOG3859 Septins (P-loop GTPases)  ali follow..  38  17.........VPLAGHVGFDSLPDQLVNKSVSQGFCFNILCVGETGLGKSTLMDTLFNTKFEGEP-----ATHTQPGVQLQSNTYDLQESNVRLKLTIVSTVGFGDQINKEDSYKPIVEFIDAQFEAYLQEELKIRRHTYHDSRIHVCLYFIAPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADAISKSELTKFKIKITSELVSNGVQIYQFP----TDDESVAEINGTMNAHLPFAVIGSTEELKIGNKMMRARQYPWGTVQVENEAHCDFVKLREMLIVNMEDLREQTHTRHYELYRRCKLEEMGFKDTDPDSKPFEAKRNEFLGELQKKEEEMRQMFVQRVKEKEAELKEAEKELHEKF 368
4 -89.600[DTZ] KOG1547 Septin CDC10 and related P-loop GTPases  ali follow..  44  247.PASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVHFKQRITADLLSNGIDVYPQK--EFDEDSEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLITHMQNIKDITSSIHFEAYRVKRLNEGSSAMANGVEEKEPEAPE....................................... 567
5 -19.100[R] COG0218 Predicted GTPase  ali follow..  19  27....................................EIALAGRSNVGKSSFINTMLNRK------------NLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWGCMIEE----YLTTRENLRA-----------VVSLVDLRHDPSADDVQMYEFLKYYIPVIIVATKADKIPRGKWNKHESAIKKKLN............................................................................................................................................................... 166
6 -17.200[R] KOG2486 Predicted GTPase  ali follow..  22  137....................................EFALVGRSNVGKSSLLNSLVRRK------------RLALTSKKPGKTQCINHFRINDKWYLVDLPGYG-----ASAPHELKQDWNKFTKDYFLNRSTLV-----------SVFLLVDASIPVKPIDLEYASWLGQNVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQDLIQGF........................................................................................................................................................ 283
7 -15.500[R] COG3596 Predicted GTPase  ali follow..  18  16.................LSGLPLWVSERILQQ--EPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTR--------DPLRFRLQIGEHF--MTIVDLPGVGESGVRD------------------TEYAALYREQLPRLDL---ILWLIKADDRALATDEHFYRQVIGE-KMLFVISQSDKAEPTS............................................................................................................................................................................ 164
8 -13.800[R] COG2229 Predicted GTPase  ali follow..  15  3..................................ENKIIFTGPVGVGKTTAIAAISDEALVQTDASASDMTLDRKRNTTVAMDYGAISLDEDTKVHLYGTPG------------------QERFNFM--------WEILSQGSMGLVLLLDNARTNPLKDLELHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKH................................................................................................................................................................. 144
9 -12.900[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  10  64.................LSIIGEVLSRR------HMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHITNKDLKAGCLVRVFWPKAKCALLRDDLVLVDSPGTDVTTELD---SWIDKFCL---------------------DADVFVLVAN-SESTLMNTEKHFFHKVNEWLSKIFILNNRWDASASEPEYMEDVRRQHMER------------HFLVEELKVANALEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATVKNDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVANK. 408
10 -12.700[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  13  48...........................RLFRRTKSNTVLLSGLSGSGKTVLFYQL----RDGSSHQGAVTSMEPNEGTFVLHNENNTKKGKVKPVHLIDVPGHSR--------------LISKLEEYLPRAAAV-------------VFVVDALEFLPNIRAAEYLYDIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDK.............................................................................................................................................................. 200
11 -11.600[E] COG4917 Ethanolamine utilization protein  ali follow..  16  3....................................RIAFVGSVGAGKTTLFNALQGNYTLARKTQAVEFN----------------------DKGDIDTPG------------------------EYFNHPRWYHALITTLQDVDMLIYVHGANDPESRLP-AGLLDIGVSKRQIAVISKTD-MPDADVAATRKLLLE.................................................................................................................................................................. 117
12 -11.500[T] KOG3886 GTP-binding protein  ali follow..  13  36..............................NTAMKKKVLLMGKSGSGKTSMRSIIF------ANYIARDTRRLGATILDRIHSLQINSSLSTLVLNLWDCGGQDTFMEN---------YFTSQRDNIFRN-------------VEVLIYVFDVESRELEK--LEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRR.............................................................................................................................................................. 211
13 -11.300[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  17  64....................................RILLMGLRRSGKSSIQKVVF------HKMSPNETLFLESTNKICREDVSNSSF---VNFQIWDFPG------------------QIDFFDPTFDYEMI-------RGTGALIFVIDSQDDYMEALAVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDD............................................................................................................................................................. 203
14 -11.100[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  20  95.....................................ILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVSVTIVDTPGIKQRIDRGYDFTGVLEWFAE--------------------RVDRIILLFDAISDEFKRC-IEALAGNEDKIRIV--LNKSDMVDHQQLMRVYGALMWSLGK.............................................................................................................................................................. 276
15 -11.100[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  11  6..........................GDSSGSPKPIRIVVVGEKGSGKSSLIMAAARNTFHPN------------PSLLPYTNLPSEFFPDRIPATVIDTSS--------------------------PEDKGKVVKEVRQADAIVLTFAFDETLDRLSKYWLPLFRQLEVRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYEVETSIQWSAQRLDQAKDVLYYAQKAVIDPVGPVFDQENNVLKPRCIAALKRIFLLSDHNMDGILSDEELNELVPCEIKQMKNVMQVTFPQGVNERGLT.......................................................... 258
16 -10.900[R] COG1084 Predicted GTPase  ali follow..  13  164....................................TVVIAGFPNVGKSTLLRTLTGAEPEVADYPFTTKGIQIGHLERKWK-----------RIQVIDTPGL----------------LDRPVEDMNNIELQAMVALENIADV--IMFIFDASETLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKVSKIIKKLEGLYEKETREA......................................................................................................................................................... 332
17 -10.700[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  22  170....................................TVLICGYPNVGKSSFMNKV-------TRADVDVQPYAFTTKSLFVGHTDYKY----LRYQVIDTPGI---LDRPFEDRNIIEMCSITALAHLRA---------------AVLFFLDISGSCGYTIAFHSIKSLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAM........................................................................................................................................................... 315
18 -10.400[O] COG4133 ABC-type transport system involved in cytochrome c biogenesis, ATPase component  ali follow..  17  2...............LEARELLCERDERTLFSGLSFTLQITGSNGAGKTTLLRLLLSRPDAGEVLWQGQPLHQVRDSYHQNLLWIGHQPGIKTRLTALENLHFYHRDGDTAQCLEALAQAGNQLSAGQQRRVALARLWLTRATL---WILDEPFT----AIDVNGVDRLTQRMAQHTEQGGIVILTTHQPLNVAESKIRRISLTQTRA......................................................................................................................................................... 204
19 -10.300[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  17  13...................................FKLVLVGDGGTGKTTFVKRHLTGEF---------EKKYIATIGVEVHPLSFYTNFGEIKFDVWDTAG------------------QEKFGG-------LRDGYYINAQCAIIMFDVT-SRITYKNVPHRDLVRVCENIPIVLCGNKVDV----KERKVKAKTITFHRKKNLQYYDISAKSNYNFEK............................................................................................................................................ 161
20 -9.740[F] COG1618 Predicted nucleotide kinase  ali follow..  14  2..........................RIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEK-SHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIG---ELISQSFVSAVEEVLESDKPVLAVLHHSSRHPLAQRFRKGFEVLTVDKGNR--DELPEKITNRFLRKLG........................................................................................................................................................................................... 184
21 -9.700[R] KOG1673 Ras GTPases  ali follow..  10  100.................................VSLKISLLGDCQTGKTTFVVKYVGDEN----------QSFLEMTGLNLMDKTFYVQGVTISFSIWDVGG------------------EKRSKD-------HIPIACKDAVAILFMFDLT-SRSTLNSVFYSQARKWNKTAIPILIGTKFDRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNK............................................................................................................................................ 257
22 -9.470[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  16  341....................................DLGLIGLPNAGKSTILNKISNAK---------PKIGHWQFTTLSPTIGTVSLGFGQDVFTVADIPGIIQGASLDK--------MGLEFLRHIE-------------RSNGWVFVLDLSNNDLQLLEVGTLEKVKTKNILI-VCNKVDIDAEKSSFAKYLQVEKFSKSQEWDCVPISALREKT............................................................................................................................................... 499
23 -9.470[R] KOG0395 Ras-related GTPase  ali follow..  17  3..................KTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSR-FLNGRFEDQYTPTIEDFHRKVYNI---------RGDMYQLDILDTSGNHPSLDNRESFDEVKRLQKQ----ILEVKSCLKNKTKEAAELPMVIC-HGELCRQVPTTEAELLVSGDENCAYFEVSAKKNTNVDEMFYVLFSMAKLPHEMS............................................................................................................................................................. 197
24 -9.360[T] KOG4252 GTP-binding protein  ali follow..  15  8.................................VAIKMVVVGNGAVGKSSMIQRYCKGIF---------TKDYKKTIGVDFLERQIQVNDEDVRLMLWDTAG------------------QEEFDA-------ITKAYYRGAQACVLVFSTT-DRGSFEAVSREKVVAEVGDIPTVLVQNKIDLLDDSCIK--NEEAEALAKRLRLRFYRTSVKEDLNVNE............................................................................................................................................ 160
25 -9.300[J] KOG0460 Mitochondrial translation elongation factor Tu  ali follow..  17  44.........................EKVFVRKKPHVNIGTIGHVDHGKTTLTAAITKCLSDLGQASFMDYSQIDKAPEEKARGITISSAHVEYHYAHVDCPGHADYIKNMITGAATMDGA-----------VSATDGQMPQTREHLLL---------ARQVGVK---------QIVVYINKVDMVEPDMIELVEMEMRELLSEYGFD.......................................................................................................................................................... 204
26 -9.290[A] COG5623 Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1  ali follow..  12  106.................IYNLHFMLEKIRMSNFEGPRVVIVGGSQTGKTSLSRTLCSYALKFNAYQP---------INLDPQQPIFTVPGC-ISATPISDIGLERINENKDLYLECISQLGQVVGQRLHLDPQVRRSGC----------IVDTPSISQLDENLAELHHIIENVNIMLVLCSETDPLWEKVKKTFGPELGNNNIFFIP.......................................................................................................................................................... 308
27 -9.250[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  17  11...................................FKLLIIGDSGVGKSSLLLRFADNTF---------SENYITTIGVDFKIRTMDINGQRVKLQIWDTAG------------------QERFRT-------ITSTYYRGTHGVVVVYDVT-NGESFGNVKLQEIENNCDSVQKVLVGNKCEENERRVVL--ESDARNYAQSMNISFFETSAKEDKNVEP............................................................................................................................................ 161
28 -9.190[M] COG0481 Membrane GTPase LepA  ali follow..  16  6....................................NFSIIAHIDHGKSTLSDRLLSDREMEAQVLDSMDLERERGITIKAQSVTLNKDGETYQLNFIDTPGHVD----------------------FSYE--VSRS----AACEGALLVVDAGQGVEAQTLANCYTAIEMNLEVVPILNKID-LPAADPERVAEEIEDIV................................................................................................................................................................ 151
29 -9.150[R] COG1159 GTPase  ali follow..  21  1........................MSTDKTYCGF---IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTTRHRIVGIHTEGPY----------QAIYVDTPGL-----HMEEKRAINRLMNKAASSSIGD-------------VELVIFVVEGTRWT--PDDEMVLNKLRDKAPVILAVNKVDNVQEKV............................................................................................................................................................................ 133
30 -9.150[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  16  7.................................FLFKFLVIGSAGTGKSCLLHQFIENKF---------KQDSNHTIGVEFGSRVVNVGGKTVKLQIWDTAG------------------QERFRS-------VTRSYYRGAAGALLVYDITETYNSLAAWLTDARTLASPNIVVILCGNKKDLDPEREVT--FLEASRFAQENELMFLETSALTGENVEE............................................................................................................................................ 160
31 -9.140[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  15  1........................MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKF---------MADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAG---DITRRSTYNHLSSWLTD--------------RNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLEASAKTGENVEDAFLEAAKKIYQNIQDGSLD.......................................................................................................................................................... 182
32 -9.110[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  15  23...................................FKILIIGNSSVGKTSFLFRYADDSF---------TPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAG------------------QERYRT-------ITTAYYRGAMGFILMYDITESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVS--SERGRQLADHLGFEFFEASAKDNINVKQ............................................................................................................................................ 174
33 -9.080[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  21  10...................................FKIVLIGNAGVGKTCLVRRFTQGLF---------PPGQGATIGVGFMIKTVEINGEKVKLQIWDTAG------------------QERFRS-------ITQSYYRSANALILTYDITESFRCLPEWLREIEQYASNKVITVLVGNKIDLAERREVS--QQRAEEFSEAQDMYYLETSAKESDNVEK............................................................................................................................................ 161
34 -9.060[R] KOG0394 Ras-related GTPase  ali follow..  13  2............................PSRRRTLLKVIILGDSGVGKTSLMNQYVNKKF---------SNQYKATIGADFLTKEVQFEDRLFTLQIWDTAG---DVNSMKSFENLNNWREEFLIQASPSDPENFPFVLIGNKVDV-------DDGNSRVVSEKKAKAWCASKGNIPYFAKVGTNVEEAFQCIAKDALKSGEEEELY.......................................................................................................................................................... 186
35 -9.010[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  22  19.................................CQFKLVLLGESAVGKSSLVLRFVKGQF---------HEFQESTIGAAFLTQTVCLDDTTVKFEIWDTAG------------------QERYHS-------LAPMYYRGAQAAIVVYDITESFARAKNWVKELQRQASPNIVIALSGNKADLANKRAVDF......................................................................................................................................................................... 145
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Godzik A. Fold recognition methods. Methods Biochem Anal. 2003;44:525-46. Review.