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Query: [S] KOG2706 Predicted membrane protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSIDDVIYVICLLGCIGAGSYVKKIADEGQRKLVSTGLGVLVVVIVSGLHSLHCFVSLALGTAAVLLVHPSKGHLVTFAVMFGYLVFFRIFDFYFGIPGHTNMIQMILTLKVSGIAFEKTAAWKRLQAHDEQKKNDQRDVHQESPIEITDYDVELQSLSAAEILHYSFNYIGVLTGPYYRYRTYRDYFEMPFKTYAPTVEATLEKLKYAVFYCALYLATNYMWPLDYALSDEFFNDRSFVYRLLYVWPTFFTFRARIYTGLTLSECVCTMAGFGAYPDESDPNNGEGPRKRYQHLKRDADKHTYNFTTIVNTRVLEVERCWTFREGMKHWNVCVQYWLAVNVYKLFPSKKYRTGATLLCSAYWHGFRPGHYFCIMGAPFYVSLEDMWDKLVRKSATGTSRRVIDVIFWIFKWFAFSYLGEAFLLSSFGNIWRFYSSVYHIGYISWAAMTALGFYLTSQRKAAERRKKRAAEKAAGGDGIAAAIEKEKAQLast
1 -137.000[S] KOG2706 Predicted membrane protein  ali  100  1MSIDDVIYVICLLGCIGAGSYVKKIADEGQRKLVSTGLGVLVVVIVSGLHSLHCFVSLALGTAAVLLVHPSKGHLVTFAVMFGYLVFFRIFDFYFGIPGHTNMIQMILTLKVSGIAFEKTAAWKRLQAHDEQKKNDQRDVHQESPIEITDYDVELQSLSAAEILHYSFNYIGVLTGPYYRYRTYRDYFEMPFKTYAPTVEATLEKLKYAVFYCALYLATNYMWPLDYALSDEFFNDRSFVYRLLYVWPTFFTFRARIYTGLTLSECVCTMAGFGAYPDESDPNNGEGPRKRYQHLKRDADKHTYNFTTIVNTRVLEVERCWTFREGMKHWNVCVQYWLAVNVYKLFPSKKYRTGATLLCSAYWHGFRPGHYFCIMGAPFYVSLEDMWDKLVRKSATGTSRRVIDVIFWIFKWFAFSYLGEAFLLSSFGNIWRFYSSVYHIGYISWAAMTALGFYLTSQRKAAERRKKRAAEKAAGGDGIAAAIEKEKAQ 489
2 -109.000[S] COG5202 Predicted membrane protein  ali follow..  17  18VHPDQLKLLFCFLSAYPFAGILKRLPAPWIRNLFSISIGLFYLIGVHYDGVLVLLFDALFTYFVAAFYRSSRMPWIIFIVILGHTFSSHVIRYYPSENTDITASQMVLCMKLTAFAWSVYDGRLP----------------SSELSSYQKDRALRKIPNILYFLGYVFFFPSLLVGPAFDYVDYERFITLSMFKPPHSLEPALGRCWRGLLWLILFITGSSIYPLKFLLTPKF-ASSPILLKYGYVCITAFVARMKYYGAWELSDGACILSGIGYNGLDSSKH--------------------PRWDRVKNIDPIKFEFADNIKCALEAWNMNTNKWLRNYVYLRVAKGFKSTLSTFTVSAMWHGVSAGYYLTFVSAAFIQTVAKYTRRHVRPFFPGPFKRVYDVIGMVATNLSLSYLIISFLLLNLKESIHVWKELYFIVHIYILIALAVFNSPIRSKLDNKIRSRVNSYKLKSYEQSMKSTSDTDML 495
3 -108.000[S] KOG2704 Predicted membrane protein  ali follow..  19  15VSVAVLRFLLCFVATIPISFLWRFIPSRLGKHIYSAASGAFLSYLSFGFSSNLHFLVPMTIGYASMAIYRPLSGFITFFLGFAYLIGCHVFYMSKEGGIDSTGALMVLTLKVISCSINYNDGMLK----------------EEGLREAQKKNRLIQMPSLIEYFGYCLCCGSHFAGPVFEMKDYLEWTEEKGIWAPSPYGAMIRAVFQAAICMALYLYLVPQFPLTRFTEPVY-QEWGFLKRFGYQYMAGFTARWKYYFIWSISEASIIISGLGFSGWTDE------------------TQTKAKWDRAKNVDILGVELAKSAVQIPLFWNIQVSTWLRHYVYERIVKGFFQLLATQTVSAVWHGLYPGYIIFFVQSALMIDGSKAIYRWQQAIPPKMLRNVLVLINFLYTVVVLNYSSVGFMVLSLHETLVAFKSVYYIGTVIPIAVLLLSYLVPVKPVRPKTRKEE..................... 465
4 -105.000[S] KOG2705 Predicted membrane protein  ali follow..  16  23VPVEALRLLLTILAGYPVAALYQKFADKTVHHMFFAGCGAGLCYFNYGLDTYHSLIAILTTYFLVLLLRKKTQIFLAINFVFHMSYLGYFYTSSNDYDILWTMPHCILVLRMIGYGFDITDGLKE----------------ESELSKDQKETALKKPPSLLELLAFSYFPSGFLVGPQFPFRRYKAFVDGEFRQHEGNVEAGVRRFGAGAFYLIVCQVGLRYLPDSYFLTPEF-AQVSFVKRIYLLGFWAKFSLYKYISCWLLTEGALICIGLTYKGEDKNGQ--------------------PDWSGCSNVKLKLLETGNTMEHYVQSFNVNTNQWVGQYIYKRLKFRTISYGAALGFLAVWHGYHSGYYMTFLMEYMVVSTEKQITRFYTKVVSDIYKLLYFITLKSYNVVYMGWCLTAFVFLKYERWIVVYGAVSYYGFTFLVLWAAFYHTFNHFFRSSSRKLAGEDQKLQDSNTDKLVEEKKPED 493
5 -31.100[T] KOG3860 Acyltransferase required for palmitoylation of Hedgehog (Hh) family of secreted signaling proteins  ali follow..  9  100...DNFALLSVLMLVHTSIKRIVLYSTNITKLRFDLIFGLIFLVAAHGVNSIRILAHMLILYAIAHVLKRRIATISIWIYGISTLFINDNFRAYPFGNICSFLSPLFTLLRVLSYNLDFLERWENLQKKKSPSYESKEAKSAILLNERARLTAAHPIQSLMNYIAYVTYTPLFIAGPIITFNDYVYQSKHTLPSI--NFKFIFYYAVRFVIALLSMEFILHFLHVVAISKTKAWENDTPFQISMIGLFNLNIIWLKLLIPWRLFRLWALLDGI---------------------------------DTPENMI---VDNNYSSLAFWRAWHRSYNKWVVRYIYIPLKNRVLTSLAVFSFVAIWHDIELKLLLWGWLIVLFLLPEIFATQIFSHYTDAVWYRHVCAVGAVFNIWVMMIANLFGFCLGSDGTKKLLSDMFCTVSGFKFVILASVSLFIAVQIMFEIREEEKRH.................. 554
6 -22.700[M] COG1696 Predicted membrane protein involved in D-alanine export  ali follow..  9  17PIYFVYLILAFLPVII---GIFKQKRLSTYETLVSLVFILFMFGGDHYQQLVAFLFYLLWQIISVFAYNSAGVFYLAIAMALFPLIWVKVAPLTGPSSQTLFSFLGILTFKSIGMIIEMRDGTLQEV-------------------------------RLPDFIRFMIFFPTFSSGPIDRFRHFQEDYHKERDDYFAMLNKAVMYLMLGFLYKHIISCLGGILLPLLENKALMVGGYFNKETILVMYVYGLNLFFDFAGYSMFAIGISYLLGIRT----------------------------------ENFN-----LSASLKDFWNRWHMSLSFWFRDYVFNRNVTSGVAYLVNMLVMGFWHGLTWYYIAYGLFHGIGLIINDAWIRKKKEINRHRKKRAFHVLCIVVTFHVVMFSLLLFSGFLNDLWFNRPLH..................................................... 418
7 -14.000[I] KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase  ali follow..  12  70.....FNLSILLLVLSNGRVALENVIKYGILITPLQWISTFVEHHYSIWSWPNLALILCSNIQILSVFGMEKILEVIAHLTIPVVVTLTHKWKNPLWSVVMMGVYVIEALKFISYGHV-KITELKTQVTDLAKKTCDPKQFWDLKDELSMHQMAAQYPANLTLSNIYYF----MAAPTLCYEKF--------RLLRIRKHFLIKRTVELIFLSFLIAALVQQWVVPTVRNSMKPLSEMEYSRCLLAIPNHLIWLLFFYTFFLIAE----LLRFADREFYRD------------------------WN------------AETIGYFWKSWNIPVHRFAVRHIYSPM-SKMSAFFVVFFVSAFFHEYLVSVPLKIFRLWSYYGMMGQIPLSIITDKVVRGGRTGNIIVWLSLIVGQPLAILMY................................................................... 475
8 -13.000[I] COG5056 Acyl-CoA cholesterol acyltransferase  ali follow..  11  102.....YVLFWLSMAAWVLQLYARSYWQRDTLLGLPLARQVFRQFFVLFSSDFLMICLSFFSYGLQVCIEKNMITLWQGFYMVLAVYWVKHRDFPIVQCVFFTLHCAVLIMKQFSYSHLTFPNKPAETISTLQAEEIVALTAKYLSRQMRSEVGNVVYPDNINFFNYVDY----LLVPSLVYSEFPR-------VAHFRWHYMAFKAGSTFGLLALTLALVDWYFVPSAVAVKDLDFIGKLRIAPIMFPAIILYLIMFYLIFAFAE----ITKFADRGFYGA------------------------WN------------TVTWDEFSREWNKPVHVFLMRHVYHSS-KKSHAVLLTFLISALVH-FRCYILTFQLLQIPLYDLQQMFAFKKR-------DILGNVFFWIGMFTGPSFLCILYIVF................................................................ 537
9 -7.690[S] KOG3097 Predicted membrane protein  ali follow..  11  46............ISIISIAFMVQFTAFQGTANLQSSILGTVSLSAIY---AALVVSCIFLPTLIIRKLTVKWTLVCSMLCYAPYIAFQLFPRFY----------TLVPAGILVGMGAAP---------ASKATYLTQVGQVYAKITEQAVDAIIVRFFGFF----FLAWQSAELWGNLISSLVLSS--GGHGNLERPPEDEIFEISMIYLSCIVAAVCIIAFFLDPLKRYGEKRKGSNSAAELSGLQLLSATFRQMKKPNLQLLIPITVFIGM---------------------------EQAFIGADFTQAYVACALGVNKIGFVMICFGVVLCSILFGSVMKYIGRTPIIVLTLITVELFWRPNPDNPIIFYAMSGLWGVGDAVWQTQINGLYGLLFRRNKEAAFSNYRLWESAGFVIAYAY---ATTLCTQMKLYILLAVLTLGCIGYVIVEILYRKKQRKLKKQEKLEAAEKEKEAAAAAAAAAL 509
10 -6.820[S] COG4682 Predicted membrane protein  ali follow..  9  12.....................................................................................................................................................................................................................................................................................................................................................AFSIVSWIALVGGIVTYLLGLWN----GYYFAVLVLGLFSAA--SYQKTVRDKYEGPTTSIYYMTCLTVFIISVALLMVGLWNATLLLSEKGFYGLAFF--LSLFGAVAVQKNIRDAGINPPKETQVTQEEYSE.............. 146
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I, Godzik A. Fragnostic: walking through protein structure space. Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W249-51.