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Query: [P] KOG2718 Na+-bile acid cotransporter, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASAISLSLLNGATPLKSNSLHKSRLTPLHLRTISCSRLSYSPSSREISLKTQSTVPISCRRSRFDFVPRCGISSNDLPTEKKKSFGEWVEFVGEAVSTAFPIWVSLGCLLGLMRPSTFNWVTPNWTIVGLTITMLGMGMTLTLDDLRGALSMPKELFAGFLLQYSVMPLSAFFVSKLLNLPPHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTVSAVIMTPLLTAKLAKQYITVDALGLLMSTLQVVLLPVLAGAFLNQYFKKLVKFVSPVMPPIAVGTVAILCGYAIGQNASAILMSGKQVVLASCLLHISGFLFGYLFSRILGIDVASSRTISIEVGMQNSVLGVVLATQHFGNPLTAVPCAVSSVCHSILGSVLAGIWRRSAPKQLEDLast
1 -96.800[P] KOG2718 Na+-bile acid cotransporter  ali  100  1MASAISLSLLNGATPLKSNSLHKSRLTPLHLRTISCSRLSYSPSSREISLKTQSTVPISCRRSRFDFVPRCGISSNDLPTEKKKSFGEWVEFVGEAVSTAFPIWVSLGCLLGLMRPSTFNWVTPNWTIVGLTITMLGMGMTLTLDDLRGALSMPKELFAGFLLQYSVMPLSAFFVSKLLNLPPHYAAGLILVGCCPGGTASNIVTYIARGNVALSVLMTAASTVSAVIMTPLLTAKLAKQYITVDALGLLMSTLQVVLLPVLAGAFLNQYFKKLVKFVSPVMPPIAVGTVAILCGYAIGQNASAILMSGKQVVLASCLLHISGFLFGYLFSRILGIDVASSRTISIEVGMQNSVLGVVLATQHFGNPLTAVPCAVSSVCHSILGSVLAGIWRRSAPKQLED 401
2 -66.700[R] COG0385 Predicted Na+-dependent transporter  ali follow..  17  2..............................................................................................RFLPDKFTTMLIATILFASVLPVRGEFAFALATKIAVGLLFFLHGARLSREAVIAGITHWKLHVTVLASTFVLFPILGLAAGWAILSQSPFYTGILYLCVLPSTVQSSIFTSMARGNVSAAVVSASASNIFGMFLTPLLVGLLFAKGGGGISMDALESILLQLLAPFVLGQVLQPFIGNFVRRKARVLAVVDRGSILMVVYLAFSEAIVEGLDDLGMMVGVNILLLAVVLLATWYGSKWLGFSRPDRITIMFCGSKKSLASGALMANAIFAGANIVLPLMLFHQIQLMACAIIARKLAERHEIR... 320
3 -60.300[R] KOG4821 Predicted Na+-dependent cotransporter  ali follow..  14  3..............................................................................TQYSLIRKIWAHSVTEFLKSQWFFICLAILIVIARFAPNFARDGQYSIGYGCVAWIFLQSGLGMKSRSLMANMLNWRAHATILVLSFLITSSIVYGFCCAVKIDDWVLIGLILTATCPTTVASNVMTTNAGGNSLLCVCEVFIGNLLGAFITPALVQMFTNRAIGALYGRVMKQVGLSVFVPLFVGQVIQNCFPKGTAYYLGYHIKIGSYMLLLIMFSSFSTAFYQWFILKLFPHEPIEGKSTRLYRYSYNIFRPFYYSKEDAICIMFCGPAKTAALGVSLITSQYGDGKLLVPLVLYQVEQVMTANFFVSLFKRWIQKDAQA 393
4 -45.400[P] COG0798 Arsenite efflux pump ACR3 and related permeases  ali follow..  17  2................................................................................SLNQQTKSNLSFFEKYLTLWVFLCIFVGIALGRLFPELAVKLVSIPIAVCLFFMMYPIMVKIDFTQAMNALRTPKPVILTLVVNWLIKPFTMVAFSQFF--ANSYIAGTILLGIAPCTAMVLMWGYLSYGNQGHTLVMVAVNSLAMLFLAPLGRWLLAANDLTVPWQTIVLSVLIYVGLPLIAGIYSRYWIFKFESRFLKYLSPIAITALLLTLILLFAFKGELIVKHILLIAVPLFIQTNFIFLISYVAALKLNLAYEDAAPAALIGASNHFEVAIATAVMLFGNSGAALATVVGVLIEVPVMLMLVELCKRTASWFPRQ 360
5 -15.700[R] COG0679 Predicted permeases  ali follow..  16  165..........................................................................................SALISAAKEPVVWAPVLATILVLVIPAAWDPTFNLIAKANSGVAVFAAGLTLAAHKF----EFSAEIAYNTFLKLILMPLALLLVGMACHLNSEHLQMMVLAGALPPAFSGIIIASRFNVYTRTGTASLAVSVLGFVVTAPLWIYVS.................................................................................................................................................................... 310
6 -12.200[P] KOG4505 Na+/H+ antiporter  ali follow..  11  43......................................................................................................MATATGLIFGPYVAKLFV-ITEELARVLLVVEVFAAGAELPRAYMLRHWRSMFVMLPVMIFGWLVSTGFMYALIPRLSFLESLAIAACITATDPVLASSIVGKGKFARRVPLRNMLLAESGCMAIPFLYLAIYLIIEKPARHAGRDVCIIILYECTFGCVLGAIIGVIARKMIKFSERRGLMDRESFLVFYFVLALF------------CGGIGTIIGVDDLLVSFCAGAAFSWDSWFSKKTEESHVSNVIDVGAIMPWPQFHMPHMDLSRLVVLAICILIARRIPAVL.......... 346
7 -11.500[R] COG3180 Putative ammonia monooxygenase  ali follow..  13  73.............................................................................................................................LFFCVQVVLAMMIAASMSPDLLVTFSGNWLLFLAIILSVIGVSTLCGWTITRMGILPGTTA----IWGSSAGAAST-LMADAYGADARLVAFMQYLRVVFVASTATIVSHLWVSGFAPIAGLPFFMTLAVGIAVPAFLVPFAIGSALNITGTLTIELPQWLLALSFAMLGWNIGLGFTHARRALMPTIVSIVVLISFSGLLALLLIKVAGIDPLTAYLATSPGGLDS--IAVIAASSNVDLPFVMALQTARLLIITLIGPALARFVADRA...... 362
8 -11.000[P] KOG3826 Na+/H+ antiporter  ali follow..  11  97........................................................................................................LALGIIIK-QFFVFPPFVETMIRKVALVMIIVRWGLATDIHFLYENALMPVTILVTAIGEIIAVTIASYFI---ISFVMSIFCALILVTVSPAVTVPAMINFKEKQ--ENILAICCVDNLFCVILFMVLSSIITDAPIATTILLNAGSIVFGCIGGIVLGWILWRFPRSDAPHTQFLLGTICIAVVLLFICLGMKFDCSTLTWEIVFLCIAVIAIGLLVRTILMLVTLSSHINFKEQIVVAL-SLLPRATFQADLAPTLLLMATILKAAILSVLITAPIFDILLNLVGSKCLSQYNP 472
9 -10.900[P] COG3263 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain  ali follow..  17  18.........................................................................................................................FAYMVSNLALAIILLDGGMRTQASSFRVALGPALSLALGVLITSGLTGMMAAWLFN-LDLIEGLLIGAIVGSTDAAAVFSLLVGSTLEINDPMAVFLTITGIVIGLGGGYLLLQMINRIALPAGLYPLLALSGGIILAVYLCGFLLGNRPIRNRYGILQNFDGLAWLAIAMFLVLGLLVNPSDLLPIAIPALILSAWMIFFARPLSVFAGLL-GFNLRERVFISW-VGLRGA-VPIILAVFPMMAGLENARLFFNVAFFVVLVSLLL............. 336
10 -10.500[P] KOG1650 Predicted K+/H+-antiporter  ali follow..  14  83........................................................................................................VLAGIILGMFLPISGKITLQTLSNLGFFIHLFLLGLRIDASIIRKAGSKAILITASYALPFSLGNLTVLFLKNTYNLPPDVVHCISTVISLNAMTSFPVTTTVLAGRLATNCSI--VCEAFSWIVALVFRMFLRDGTLASVWSFVWVTALILVIFAFWLGVSLPDGPPLGTGLTTKLEMFATSLMLCFISISGLQTNFFIIGESHVKIIEAVILITYGCKFLGAAASAYCNIQIGDAFSLALLMCCQGYTCVMWKDEKVLNTECFNLLIITLLLVTGISRFLVVCLYDPSKRYRSKS 455
11 -9.990[C] COG1883 Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit  ali follow..  14  114....................................................................................................................................LIFFGLGA---MTDFGPMIADPKTALLGAAAQIGVFVAMLVALALGFNLKEAASIGII--GGADGPTTIYLTTKLAP---ATAVAAYSYMSLVPLIQPPVIKALTTPEERKIRMFPIVSMIVIGLLVPLMIGNLFREVVQRLSKAAQEELMNIVTIFLGLGVGSTMRAE-SFLTAKTLMILTLGVVAFASATAGGVLFGKLMMKISGGKINPMIAAGVSAVPMSARVVQRLASEEDPGNFILMHAMGPNVAGVI............... 386
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Jaroszewski L, Slabinski L, Wooley J, Deacon AM, Lesley SA, Wilson IA, Godzik A. Genome pool strategy for structural coverage of protein families. Structure. 2008 Nov 12;16(11):1659-67.