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Query: [H] KOG2743 Cobalamin synthesis protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCTLast
1 -109.000[H] KOG2743 Cobalamin synthesis protein  ali  100  1MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVASMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT 395
2 -85.000[R] COG0523 Putative GTPases (G3E family)  ali follow..  29  2.......................................TPIAVTLLTGFLGAGKTTLLRHILNEQHGFKIAVIENEFGEVSVDDQLIGDRA-----TQIKTLTNGCICCTRSNELEDALLDLLDSRDAFDRLVIECTGMADPGPIIQTFFSHDVLCERYLLDGVIALVDAVHANEQMNQF------TIAQSQIGYADRILLTKTDVAGDSE--KLRERLARINARAPVYTVVHGDIDLSQLFNTSGFMLEENVLASQ---PRFHFIADKQNDVSSIVVELDYPVDISEVSRVMENLLLE--------SADKLLRYKGMLWIDGEPNRLLFQGVQRLYSAD-WDRPWG-DETPHSTLVFIGIQLPEDEIRAAFVGLR.................. 317
3 -21.600[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  18  2.......................................KRPLIIGVGGPVGAGKTMLIERLTRYTKGYSMAAITNDIYTKEDARILL--NTSVLPADRIAGVETGGCPHTAIRENFAAIEEMCDKHPDLQLLFLESGGDNLSATFSPDL------------DFSIYIIDVAQG---------EKIPRKGGQGMIKSDLFIINKVDLAPGANVEVMKADTLKSRGNKDFFVTN.................................................................................................................................................................. 181
4 -18.900[R] COG2403 Predicted GTPase  ali follow..  12  130..................................TEYDILEKPSLKILGTGRIGKTAVSAYAARHERQYNPCVVAMGRGGPE-EPEIVHGDRIEITPEFLMEQSDGCRRCGGGITNMKRGAETANRLDA-DFVILEGSGAAIP---------------PVKSNRHIVLVGANQPLINIKNFFGP--------RIGLADLVIVTMCEMAGDEKVREIVDFIESINPEAEVITTVFRPKPLGEIEGKNVLFATTAPDSVKDLLVEYLESEYSCRVVGTTPHLSNRPLLQRDIERYIEDA---------------LTELKAAAVDVATKDAL---------------------EAGLEVIYCDNIPVVRDGAQDELDDAIISVVERAIADFNLRKTP. 464
5 -13.100[R] COG3596 Predicted GTPase  ali follow..  16  5........NFEVLQPLQNSLSGLPLWVSERILQQINQLTHYEPVIGIMGKTGAGKSSLCNALF----AGEVSPVSDVAA-------------------------------CTRDPLRFRLQ------GEHFMTIVDLPGVGESGVR-DTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVIGEAYRH-----LFVISQSDKAEPTSGGNILSTEQKQNISRKICLLHELFQPVHPVCAVSV.................................................................................................................................................... 199
6 -12.700[R] KOG1533 Predicted GTPase  ali follow..  13  2..........QMNLNEKKQLLRVRVYATSEKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLTDSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMD-PNGALKYCIE--LGANCNWLLQKIEANKYLIIDCPGQLE-EGELWKVI--RFLEKSGVRLCALHLADSLYCSDPSKFISVALSTLATMVTMEMPQVNCLSKADLFSEDGTYDLEFFSHLPD........................................................................................................................................................................... 223
7 -12.500[H] COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein  ali follow..  12  1.........................................MNIFGITGWKNSGKTTLTEKLVAVRRGWKVSTVKHAHHDFDIDKPGADSFRHRQAGATEVAIVSGALMHELRGEDEPPLESILSRLAPCDIVLVE--GYKRRKIETRRLEAKDRTPLSAGDPNIVAIAADFAVTDKFDLDDVKSIVDFIERTTGLV...................................................................................................................................................................................................... 166
8 -12.200[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  13  1MDPMESSSEQDIVEESQKLVDSLDKLRVSAASSSSNFKKKPIIIIVV-GMAGSGKTSFLHRLVCFDSKSHGYVVNLDPAVMSLPFGANIDIRDTVKYKEVMK-PNGGILTSLNTKFDEVVSVIEKRADQLDYVLVDTPGQIE---ITEAFASTFPT--------VTYVVDTPRSSSPITFMSNMLYACSILYKTRLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTATL.............................................................................................................................................................. 245
9 -11.900[R] KOG2486 Predicted GTPase  ali follow..  13  114....................QVVQADYVKSSVKTEDCPADGLPEFALVGRSNVGKSSLLNSLVRRK-------------------RLALTSKKPGKTQCINHFRIN------------------------KWYLVDLPGAPHELKQDWNKFTKDYFLNRSTLVSVFLLVDASIPVKPIDLE-----YASWLGQNQVPMTLIFTKCDKRKKKKNGGPEANIKEFQDLIQGFFETTPPW.............................................................................................................................................................. 290
10 -11.800[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  19  93..........................................PMILLVGQYSTGKTTFIRYLLEEPTTDRFIAVMHGDEEGSIPGNALV-VDAKKQFRALSGFGNAFLCSTLPNQVLESVT------------IVDTPGILS-TGVLEWFA---------RVDRIILLFDA----HKLDISDEFKRCIEALAGNEDKIRIVLNKSDMVDHQQLMRVYGAL............................................................................................................................................................................... 270
11 -11.700[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  13  52......................................RTKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAVTSMEP------EGTFVLHNENNTKKGKVKPVH-----------------------------LIDVPGHSRLISKLEEYLPR--------AAAVVFVVDALEFLPNIRAASEY-LTNASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEK............................................................................................................................................................................. 196
12 -11.600[K] KOG1534 Putative transcription factor FET5  ali follow..  11  6............................................AFVCGVASSGKSTFCGALMSKSVGRSCHLVNLDPAAENFEWEPTVDIRDLISIDDVME-PNGGLIYCFE--LMENLDWLNEEIGDYDYLIFDMPGQIE----ILPALIRHLQVTLNFRPCAVYLLESQFLVDRTKFFAGVLSAMSAMVMMEVPHINLLSKMDLLKDNNNITKAELKRFLNTDPLLLTGEINE............................................................................................................................................................... 206
13 -11.500[F] COG1618 Predicted nucleotide kinase  ali follow..  17  4...................................EGKEKTMLRIAVTGSPGVGKSTVVAKTAEK-GGIRTAEIRKEGHREGFSIRDLATGKTGILSHVKGSGPRLGKYHVNLDDLERIGANAVRNALACDLVVIDEIGPME-------------LISQSFVSAVEEVLESKPVLAVLHHSSRHPLAQRFRKGFEVLTVDKGNR-DELPEKITNRFLRKLG.............................................................................................................................................................................. 184
14 -10.900[J] KOG0468 U5 snRNP-specific protein  ali follow..  18  77..PDVETIVQEEDAQPLDKPLIEPVKKLKFQIKEQMDTPPLIRNVALVGHLHHGKTTFVDCLIRQT---------HPQFETMEERQLRYTDTLFTEQERGCSIKATPVTLVLQD----------VKQKSYLLNIFDTPGHVN--------FSDEATAAMRMSDGVVLFIDAAEGVMLNTERLLKHAVQERQAIT-----VCINKIDLPPQDAYFKLKHIVEEVNGLLSTYGAPDDNLLVSPILGNVCFA.................................................................................................................................................. 313
15 -10.900[R] COG1084 Predicted GTPase  ali follow..  16  141....................DLDFLDFAKNKLRNMPTVDLDAFTVVIAGFPNVGKSTLLRTLTGAE------PEVADY--------------------------------TTKGIQIGHLE------KWKRIQVIDTPGLLDRPVEDMNNIELQAMVALENIDVIMFIFDASETCGY-TLESQYSLYLGIRSVFDIPVVTVFNKMDLAENVKY--LEEYINMVEDPLKVSAFEGRGVS............................................................................................................................................................. 315
16 -10.300[F] COG2019 Archaeal adenylate kinase  ali follow..  13  2...........................................RSVITGVAGVGKTTVLDIVAR-----ESGIPVVNYGTL---FEVAKRRGLVENRDQIRKLSR--------ETQVDLQKLAGEEIGKMENAIVDTMSIKTPFGYLPGL--PEWVLRSINASVFVIIADPAIIKRRRDNDPTRARDDEGVDSIR-ATVKIVKNEEGKPEQAADEIVRVIK.............................................................................................................................................................................. 181
17 -10.300[J] KOG0469 Elongation factor 2  ali follow..  16  13...................................MDRKRNIRNMSVIAHVDHGKSTLTDSLVSKAGIIA-----------SKAGETRFTDTRKDEQERCITIKSTAISLFFELE-TVEVDGKKEKYNGFLINLIDSPGHVD--------FSSEVTAALRVTDGALVVVDCVSGVCVQTETVLRQAIAERIKPV-----LFMNKMDLGAEELFQTFQRIVENIN........................................................................................................................................................................... 198
18 -10.200[R] COG0218 Predicted GTPase  ali follow..  17  5.....................THNAEILLSAANKSHYPQDELPEIALAGRSNVGKSSFINTMLNR---KNLARTSGKPGKT-------------------------------------QLLNFFNIDDKMRFVDVPGYGYARVSKKEREKWIEEYLTTRENLRAVVSLVDLRHDPSADDVQ-----MYEFLKYYEIPVIIVATKADKIPRGKWNKHESAIKK............................................................................................................................................................................. 163
19 -10.000[R] COG3911 Predicted ATPase  ali follow..  10  10.............................................VLTGGPGSGKTTLIAAL-----RRAGFATSVVAGRGIVRDQSSIGGTALPWSDRT----------LFAELMLSWEMRSYQNAVEQKGPVFFDRGVPETLGYLRLSGLPSTAAKRFRYNPRVFIADEERKQTPDEAKCTYHALAEIYTELGY-ELVPLPLAPV--ETRLRFVLADAG.............................................................................................................................................................................. 181
20 -9.800[R] COG2229 Predicted GTPase  ali follow..  17  6............................................IIFTGPVGVGKTTAIAAISDEADRKRNTTVAMDYGAISLDEDTKVH-------------------------------------------LYGTPGQERFNFMWEILSQG--------SMGLVLLLDNARTNPLKDLEFFLHSFRGLLEKAPV--VVGITKMDIRSQPGIDVYHKYLAKHNLNVPVFEID.................................................................................................................................................................. 154
21 -9.680[E] COG4917 Ethanolamine utilization protein  ali follow..  22  1.........................................MKRIAFVGSVGAGKTTLFNALQGNYTLAR-----------------------------------------------------TQAVEFNDKGDIDTPGE-----FNHPRWYHALITTLQDVDMLIYVHGANDPESRLPAGLLDIGVSKRQ-------IAVISKTDMPD-ADVAATRKLLLETGFEEPMFELN.................................................................................................................................................................. 128
22 -9.640[R] COG1160 Predicted GTPases  ali follow..  17  2........................................ATPVVALVGRPNVGKSTLFNRLT----RTRDALVADFPG-------------------------------LTRDRKYGHAH------AGYDFIVIDTGGIDGTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIGIANYLRQRQNKIT----VVVANKTDGIDADSHC---AEFYQLGLGEIEQIAASQGRGVTQLME....................................................................................................................................................... 158
23 -9.630[V] COG3896 Chloramphenicol 3-O-phosphotransferase  ali follow..  10  5.......................TRARRMRYRLAAMAGMPEGKLILLNGGSSAGKTSLALAFQDLAAECWMHIGIDLFLARVRPEYYTWDSAVEADGLEWFTVHPGPILDLAMHSRYRAIRAYLDNGMN---VIADDVIWTREWLVDALRVFEGCRVWMVGVHVSDEEGARRELERGDRHPGWNRGSARAAHADAEYD-FELDTTATPVHELARELHESYQA............................................................................................................................................................................. 209
24 -9.250[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  22  59..............................................VTGTPGAGKSTFLEAFGMLREGLKVAVIAVD-GSILGDKTRMNDLARAEAAFIRPVPSSGHL-----GGASQRARELMLEAAGYDVVIVETVGVGQ-----------SETEVARMVDCFISL---------QIAGGGDDLQGIKKGLMEVADLIVINKDDGDNHTNVAIARHMYESA............................................................................................................................................................................ 220
25 -9.180[J] COG4108 Peptide chain release factor RF-3  ali follow..  15  2............................LMSTTPYFGEVSKRRTFAIISHPDAGKTTITEKVL-------FGRAIQVAGTVK-SNQHAKSDWMEMEKERGISVTTSVMQFPYGDCLVN---------------LLDTPGHED--------FSEDTYRTLTAVDSCLMVIDAAKGV-----EDRTRKLMEVTRLRDTPIVTFMNKLDREIRDPMELMDEVENELKIACSPITWPIGC............................................................................................................................................................... 177
26 -9.110[R] COG1159 GTPase  ali follow..  18  2...................................STDKTYCGFIAIVGRPNVGKSTLLNKLL----GQKISITSRK---------------------------------TTRHRIVGIHTE-----GPYQAIYVDTPGLMEEKRAINRLMNKAASSSIGDVELVIFVVEGT------RWTPDDEMVLNKLRDGKAPVILAVNKVDNVEKVDLLPHLQFLASQMNFLDIVPIS.................................................................................................................................................................. 155

FFAS is supported by the NIH grant R01-GM087218-01
1 3 6 3 0 1   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Veeramalai M, Ye Y, Godzik A. TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics. 2008 Aug 31;9(1):35