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Query: [R] KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MVKRQRIESSNVPLSAFAVRQLTLSKAARKKDNSSGKKRSVSEEESQDKYEDEMKTEGEFPSYKHTLVQVVVPGVDHRTKLHSESSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSENVPHSPQSSNDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFGATYSSACMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPNFETVIAFRENENGLSKIARVLPFAKRLFSFKNLLQDASSISNNFEITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVPSGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSREDMKSSHREKKSIYQHKEYMPDFLSSRDEFQLTLLESTWQYLPDPNVNKVTSADNRMLGLLSYLYFNCNLQRWDFTTSLTACQPIATAFKGSSKGIDAVNIIGEPLNVNDVAKTINGTLMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGPLNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYLDRNHDRVAVGAHRRRVRRNIIRRSTFVGLast
1 -137.000[R] KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein  ali  100  1MVKRQRIESSNVPLSAFAVRQLTLSKAARKKDNSSGKKRSVSEEESQDKYEDEMKTEGEFPSYKHTLVQVVVPGVDHRTKLHSESSKNDSEITPDINRSKVNPQEYSEFSVASPQTISPSLPLNLDDETVSENVPHSPQSSNDAIPVIKITEENSFRVKDTLYVGLHKDQKLAMVGTFIFRSVRGKFQLFGATYSSACMSWFPLNAPLAFATPVFSAIDNALPAMQISEYEEDSLNLRSFAVPSYSPKEHEYELEPKDILPNFETVIAFRENENGLSKIARVLPFAKRLFSFKNLLQDASSISNNFEITPESWCSFSNQLLFSTSKSDYVVPRLMVCGPKGSGKSSFSRYITNRLLQQYRHIAYLDLDPGQPEVVPSGHISLYYINSPLQGPVFARMLFPTYMLRLHLGDISPQKDPDHYIACVTRLFAEYKDYIFNQEISQKEIIPLIINCPGWIRGGGAELLSSIVDICQPTEVVYMSREDMKSSHREKKSIYQHKEYMPDFLSSRDEFQLTLLESTWQYLPDPNVNKVTSADNRMLGLLSYLYFNCNLQRWDFTTSLTACQPIATAFKGSSKGIDAVNIIGEPLNVNDVAKTINGTLMALYACDTASLDNSNTQRIVSSPEGIPLIINDGLPLDPNTSHCLGLIVLRTIDLKRNEFHFVGPLNLELIKDAYAKSLKIVLERGRLELPVYAMLDHRLAQYSELPYLDRNHDRVAVGAHRRRVRRNIIRRSTFVG 736
2 -59.000[A] KOG2749 mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1  ali follow..  15  1...........................................................................................................................................................MFGPQIRRVKLEKQSELRIESPLRLRLLDGKAEIFGYELPHEVW-----ITFPPLMTFAVFTWYGATIEIDGIT---------------------------------------------------------------GNEYISCETPMVNYLGLHNSLQVQRHRVTSSTRDASSQGPRVIIVGDIDSGKSTLAKMLLNWAVKDGWKPTFVDLNVGQSSITIPGTIAAAPIKMLVDPVEGFPLDKA---LIHYFGLTNPSVNLRLYRTLVEELARELKEEFSAN--AESRASGMVIDTMGFIVREGYALLLHAIRTFNASLVIVVGQEEKLVYDLK---------------KNLKFKKNLQVLNLEKSEGVFSRSSDFRKTLRNSNIQNYFYGVTNDLT-------------VYTKTVKFSDVQVYRIGDFRVSGSTSAHQRGNDPLKITLVTIDEHL----------VNKVLAISYAIKPDQIISSIVAGFVCIKNVDISEERITYVSPSAAELPSKI--------LILGTLTWHVT............................................ 423
3 -58.800[R] COG1341 Predicted GTPase or GTP-binding protein  ali follow..  17  5..........................................................................................................................................................................................................................................................................................................ASNKAMFTNDVPQDRLLAVEKIES-----LRKPAKVMIIGDVDTGKTTLTIYLANELLSRGFRVAIIDSDIGQKGILPPATISLAFVDSHFTSLDDLKAF-----SHYFIGTITPNQYFGEMVVGVMKLSELAMK----------FSDVVLIDTTGMIYGSGVELKRMKIEAVKPNLILALERNNELAPILKGYED--------------------ITIRLEVSEKAKDFSRSERRELRREKWRKYFENSKIVNFNLDDVLVTG----TSLFQGEEIGDTEKSLLERLFKWLIIHGRKIGNKYFVVKVDASEGPRIVDKNVVKYFDF-SKLSNILLGLIDKQGFCIGLGILKSINFKEKKIEVLTPVED--------LSSVAEIRFGRVRVRE---------DGEELGLLD........................... 353
4 -52.200[A] COG5623 Pre-mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1  ali follow..  13  2...........................................................................................................................................ASLPGIDEHTTSEELITGDNEWHKLVIPKGSDWQIDGKLIVKVNSGIVEIFGTELAVDDEYTFQIYAVEETELLWKCPDLTTNTITVKPNH-------------------------------------------------------------------------------TMKYIYNLHFMLEKIRMSNFEGPRVVIVGGSQTGKTSLSRTLCSYALKFAYQPLYINLDPQQPIFTVPGCISATPISDILDAQLPTWGQSLKQPMVKNFGLERINENKDLYLECISQLGQVVGQRLHLD--PQVRRSGCIVDTPSISQLDNLAELHHIIEKLNVNIMLVLCSETDPLWEK-------------VKKTFGPELGNNNIFFIPKLDGVSAVDDVYKRSLQRTSIREYFYGSLDTA--------LSPYAIGVDYED-----LTIWKPSNVFDNEVGRVELFPVTITPSNLQHAII-------------AITFAERRADQATVIKSPILGFALITEVNEKRRKLRVLLPVPGRLPSKA--------MILTSYRY............................................... 443
5 -12.900[R] KOG1533 Predicted GTPase  ali follow..  18  21..............................................................................................................................................................................................................................................................................................................................EKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEM-----------ITVNDVMDRLGLG---PNGALKYCIETLGANCNWLLQKIEANHKK------LIIDCPGQLEGELWKVIRFLEKSGVRLCALHLADSLYCSD......................................................................................................................................................................................................................................................... 175
6 -11.900[K] KOG1534 Putative transcription factor FET5  ali follow..  17  6.............................................................................................................................................................................................................................................................................................................................................AFVCGVASSGKSTFCGALMSYMKSVGRSCHLVNLDPAAENFEWEPTVDIRDL-----------ISIDDVMEELDYG---PNGGLIYCFEFLMENLDWLNEEIGDYDED------LIFDMPGQIEPILPALIRHLQVTLNRPCAVYLLESQFLVD......................................................................................................................................................................................................................................................... 146
7 -11.700[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  15  18...................................................................................................................................................................................................................................................................................................................KLVDSLDKLRVSAASSSSNFKKKPIIIIVVGMAGSGKTSFLHRLVCHTFDSKSHGYVVNLDPAGANIDIRDTVKYKEVMKQYLGPN---------------GGI---------LTSLNLFATKFDEVVSVIEKRADQLDYVLVDTPGQIEASGAIITEAFASTFPTVVTYVVDTP.............................................................................................................................................................................................................................................................. 180
8 -10.300[R] KOG1424 Predicted GTP-binding protein MMR1  ali follow..  10  1MGRRRAPAGGSLGRALMRHQTQRSRSHRHTDSWLHTSELNDGYDWGRLNLQSVTEQSSLDDFLATAELAGTEFVAEKLNIKFVPAEARTGLLSFEESQRIKKLHEENKQFLCIPRRPNWNQNTTPEELKQAEKDNFLEWRRQLVRLEEEQKLIRVIERSDIVVQIVDARNPLLFR---ENVILINKADLLT---AEQRSAWAMYFEKEDVKVIFWSALAGAIPLNGDSEEEANRDRDSPSLSENPTTDEDDSEYEDCPEEEEDDWQTCSEEDGPKEEDCSQDWKESSTADSEARSRKTPQKRQIHNFSHLVSKQELLELFKELHTGRKVKDGQLTVVGYPNVGKSSTINTIMGQTLYVEPGLCLCDC-PGKAEMTCSGILPIDQMRDHVPPVSLVCQNIPRHVLEATYGITPREDEDPHRPPTSEELLTAYGYMTAHGQPDQPRSARYILKD--YVSG-------KLLYCHPP....................................................................................................................................................................................................................................................................... 550
9 -10.300[D] COG3640 CO dehydrogenase maturation factor  ali follow..  13  2......................................................................................................................................................................................................................................................................................................................................EGFGMPKLIISGRGGSGKSTLVTLIAHTLKEQKKRVLVVDSDESNIGLSG--ILGIEPAEKTLMDYLGGKPRVMKKLRS--IGKIDHAME--PMGAVTRDFLNHVRLEEDQ----------VLVDTEAGVEHFGRGIVEGVVMVVDPS...................................................................................................................................................................................................................................................................... 177
10 -10.000[OK] COG0378 Ni2+-binding GTPase involved in regulation of expression and maturation of urease and hydrogenase  ali follow..  11  2........................................................................................................................................................................................................................................................................................................................................KRPLIIGVGGPVGAGKTMLIERLTRYLSTKGYSMAAITNDIYTKE------------ARILLNTSVLPADRIAGVETGGCPHTAIREDASMNFAAIEEMCDKHPDL-------------LFLESGG---AQGEKIPRKGGQGMIKSDLFIINKVDLAPYVGANVE................................................................................................................................................................................................................................................... 162
11 -10.000[L] KOG1803 DNA helicase  ali follow..  10  238...................................................................................................................................................................................................................................................................................................................TLNPSQVAAVSAAMN------TQRNLLCIQGPPGTGKTRVIAEIVHQLMKKKKKVLV----------CAPTHVAVRNAMDATTGRMIEEMPEEKAEQQLCLLANTKDSTMSTSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFST---LGTSSIQIVDEAAQCTEPATWVPVLTTPSCKKLILVGDQKQLPAVVLSDKAMKGNFKLSLMEKLAEEFSSNNINILLNEQYRMNKKIMNWSNE---------------------------------------------VFYENQLTAHSTVSDITLRDICPNLPEDHVLNNPIMFESHSFTNTDELNLV---LVVDLGINPKAIAVISPYYAQIEKLRRSIPFRVDVFQGH-ERQVVIFCLVRDNDEGQIGFLN---ETRRLNVAVTRARRQF-----LIG 646
12 -9.800[R] KOG2878 Predicted kinase  ali follow..  15  1..................................................................................................................................................................................................................................................................................................................MSSLEIIVDKILKFLEKQPKPEGRPFILGISGPQGSGKSTLASALDTELTRKNESVVKFSLDDFYLTHAEQVELAKNNPNNPLVGLAGTH-------------------DVTFLNNVLNAFIPFYDKSKFGGYGDRGDESQ-YVIFEGWMVGF..................................................................................................................................................................................................................................................................................... 155
13 -9.530[C] COG3954 Phosphoribulokinase  ali follow..  11  2.......................................................................................................................................................................................................................................................................................................................................SAKHPVIAVTGSSGAGTTTTSLAFRKIFAQLNLHAAEVEGD-RHISYFGPEANDFSLLEHTFIERKYLHTYDEAVPWNQVPGTFTPWQEPTDVL-FYEGLHGGVVT--PQHDVARHVDLLVGVVPI---RGHSREAVMDSVVRSMDDYINYITPQFSRTHI........................................................................................................................................................................................................................................................ 203
14 -9.430[E] COG1703 Putative periplasmic protein kinase ArgK and related GTPases of G3E family  ali follow..  18  34......................................................................................................................................................................................................................................................................................................................PRHQALSTQLLDAIMPYCGNTLRLGVTGTPGAGKSTFLEAFGMLLIREGLKVAVIAVDPSSP---TGGSI---------LG---TRMNDLARAEAAFIRPVPSSGHLGGASQRARELMLLCEAAGYD----------VIVETVG-IAGGGDDLQGIKKGLMEVADLIVINKDD............................................................................................................................................................................................................................................................. 203
15 -9.420[F] KOG3308 Uncharacterized protein of the uridine kinase family  ali follow..  9  2.......................................................................................................................................................................................................................................................................................................................................TRKTIIVGVSGASCSGKSTLCQLLHAIF----EGSSLVHED-GIADWDCQESLNLDAFLENL-----HYIRDHGVLPTHLRNRENKNVAPEALIEYADIIKEF------KAPAIPTLEQHLVF-----VDGFMMYVNEDLINAFDIRLMLVTDFD.............................................................................................................................................................................................................................................................. 148
16 -9.410[R] KOG2484 GTPase  ali follow..  10  3LKRLKTKKS----------KRLTGRLKHKIEKKVRDHNKKERRAAKKNPKKGSKKQKLIQIPNICPFKDDILKEVEEAKQRQEAERLARREAFKAEREQNKFKTLESMVEDADMRSTVHGIMHENDAQDQDEKKYKNAVTKEQSLKQYFKEFRKVIENADVVLEVVDARDPLGTRGNKRLVLVLNKADLV----RENLNNWIKYFRRSGPVTAFKASTQDQANRLGRRKLREMKTEKAMQGSVCI--------------------------------------------------------------------AELLMSMLGNYCRNKKTSIRVGVVGIPNVGKSSIINSLTRG-VELDSKIKLIDC-PGNSHAVLKNAQRVGDVKDPFTIAESVLKRASKEYFCTMYD-ITNYDTFEEFFAKKAARMGKFLKKGVPDVVAAAR---SVLN---WNTG-------KIKYCTQP....................................................................................................................................................................................................................................................................... 419
17 -9.390[H] KOG3220 Similar to bacterial dephospho-CoA kinase  ali follow..  11  3............................................................................................................................................................................................................................................................................................................................................IVAVTGGIATGKSTISKVFERQ------GIPVIDADKIAREIVEPGQPCWRQIRE-VFGDEVLLPSNRAVLGKMIFEDKELRGKLNKITHIHRKIFWQVCKLLVTGHAWIVLDLPLLFETGVLMDFIHKIVCVTCDSDKQLERLIALSESEARHRVDSQMPLDKKCEKSHFVIDNNGSVEEAE............................................................................................................................................................................................................................. 186
18 -9.310[G] KOG3354 Gluconate kinase  ali follow..  15  2..............................................................................................................................................................................................................................................................................................................................TVTPINPTNQPYKYVFVVIGPAGSGKTTMAKAVSEKL-----GFEYIEGD----DLHPKANIEKMSQGHPLNDND-------LHNCGGACAMELDKESIKGVVLTCSALKRSYRDILRSSLEHRPAILRFI-----YLAAMKADMVESQLAILEAKDVITISVENGKEQS........................................................................................................................................................................................................................................................ 175
19 -9.290[R] KOG2486 Predicted GTPase  ali follow..  15  119..........................................................................................................................................................................................................................................................................................................................DYVKSSVKTEDCPADGLPEFALVGRSNVGKSS----LLNSLVRR-KRLALTSKKPGKTQ-------KWYLVDLPGYG----------------------------YASAPHELKQDWNKFTKDLNRSTLVSVFLLVDASIPVKPIDLEYASWLGQNQVPMTLIFTKCDKRKKK......................................................................................................................................................................................................................................................... 262
20 -9.120[P] KOG0635 Adenosine 5`-phosphosulfate kinase  ali follow..  14  96.......................................................................................................................................................................................................................................................................................................................VWHESSICRCDRQQLLQQKGCVVWITGLSGSGKSTVACALSKALFERGKLTYTLDGDLTFKAFADVGVICIASLISPYRR----SLLPDGDFVEVFMDHVCESRDPKLYKLARAGKIKGFTGIDDPYEAPVNCE--VVLKHTGDDESCSPRMAENIISYLQNKGYL................................................................................................................................................................................................................................................................... 291
21 -9.020[R] COG0218 Predicted GTPase  ali follow..  13  9..........................................................................................................................................................................................................................................................................................................................EILLSAANKSHYPQDELPEIALAGRSNVGKSSFINTMLNR-----KNLARTSGKPGKTQ-----LLNFFNIDDKMR-PGYGYARVSKKEREKW------GCMIEEYLTTRENLRAVV----------------SLVDLRHDPSADDVQMYEFLKYYEIPVIIVATKADKIPRG......................................................................................................................................................................................................................................................... 152
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Veeramalai M, Ye Y, Godzik A. TOPS++FATCAT: fast flexible structural alignment using constraints derived from TOPS+ Strings Model. BMC Bioinformatics. 2008 Aug 31;9(1):35