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Query: [R] KOG2940 Predicted methyltransferase, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MRRINSLYGRIGLLKRVPEKSTKQAHTFLASLSFSTEGAYGGDGEFQQNSSKVKIFDRDLKRIHRDRAAWLSRQKNDSFVDAVADNLLDRLEDCKKSFPTAFCLGGSLGAVKRLLRGRGGIEKLIMMDTSYDMIKSCRDAQDDSLDNSIETSYFVGDEEFLPVKESSVDLIISSLGLHWTNDLPGSMIQCKLALKPDGLFLAAILGGETLKELRIACTLAHMEREGGISPRLSPLAQVRDAGNLLTRAGFSLPGVDVDEYVVKYKRAMDLIEHLRAMGETNALLERNKILNRETAVATAAIYDSMFATEDGTIPATFQVIYMTGWREHSSHPQAKRRGSATVSFTDLQKQFGGQSLast
1 -109.000[R] KOG2940 Predicted methyltransferase  ali  100  1MRRINSLYGRIGLLKRVPEKSTKQAHTFLASLSFSTEGAYGGDGEFQQNSSKVKIFDRDLKRIHRDRAAWLSRQKNDSFVDAVADNLLDRLEDCKKSFPTAFCLGGSLGAVKRLLRGRGGIEKLIMMDTSYDMIKSCRDAQDDSLDNSIETSYFVGDEEFLPVKESSVDLIISSLGLHWTNDLPGSMIQCKLALKPDGLFLAAILGGETLKELRIACTLAHMEREGGISPRLSPLAQVRDAGNLLTRAGFSLPGVDVDEYVVKYKRAMDLIEHLRAMGETNALLERNKILNRETAVATAAIYDSMFATEDGTIPATFQVIYMTGWREHSSHPQAKRRGSATVSFTDLQKQFGGQS 355
2 -53.100[R] COG4106 Trans-aconitate methyltransferase  ali follow..  15  4....................................................................SAQQYLKFEDERTRPARDLLAQVPL--ERVLNGYDLGCGPGNSTELLTDRYGVNVITGIDSDDDMLEKAADRLP-------NTNFGKADLATWKP-AQKADLLYANAVFQWVPDHLAVLSQLMDQLESGGVLAVQMPDNLQEPTHIAMHETADGGPWKDAFSGGGLLPPPSDYFNALSPKSSR-VDVWHTVYNHPMKDADSIVEWVKGTGLRPYLAAAGEENREAFLADYTRRIAAAYPMADGRLLLRFPRLFVVAVKK............................ 256
3 -34.800[R] KOG2899 Predicted methyltransferase  ali follow..  10  43..............................ESNVEATSRPPAQSPKKRLHLNGKPMQNKDLNFKYGNYK--HYYGKRILNKDFHDIRLDVLGTQPFRNKQLLDIGCNSGHLSIQIARKFEVKSLVGLDIDRGLINDAQKTVSHLKRHAVHGNYVLEDDVLLEIERPQFDVILCLSVTKWISGLKQAFRRMYLQLRPGGKLILEPQSFDGYKRRKKLSVSFIQEQIRDNYNAIKFRPDHFTEYLLSPEVGFA----EMKLMGIPEHCKVGFKRPI................................................................................. 317
4 -32.200[R] KOG2361 Predicted methyltransferase  ali follow..  13  45.........................................................TSTNTDKYERDAKKYWDIFYKHHGDRFFKDRHYLDKEVSGKSVILEVGCGAGNTIFPLIATYPDIFVYACDFSPRAVELVKAHDEYTETRCAFACDLTGDGLDKHISPSSVDIVTMIFVLSAVEKMSSVLQNIRKVLKPNGCILFRDYAVGDLAQERFS-QRISENFYVRGDGTRAFYFSNEFLETLFSEQGFEVEELDV---------------------CCKQVENRSRELVMNRRW----------------VQATFR-------RTNGNKNPCDSLTPAKLDKSE......... 300
5 -32.000[R] KOG3010 Methyltransferase  ali follow..  11  1............................................................MAALSEKEA----EAYLDARPRYPIDWFKKIAARTQDHKFAWDVGTGNGQAAIGLVEHY--ENVVATDINEAQLQRAIKHSRIS-YHHTPTTISEDEMVDLLGGENSVDLIVAAQAVHFF-DLNVFYNVAKRVLRKEGGL--IAVWVYNDIIISHEIDPIMKRLVDSTLPFRTPIMNLAFDGYKTLTFPFETIGMGSEGKPITLDSLKGFIGFLRSWQPAMKAKEKGV---ELINEDLITKFEEAWGDETQVKDVFYKAHMIVGKIPEEKFESDQVLSNKGRLLLETEVGRNQKR 287
6 -31.500[R] KOG1541 Predicted protein carboxyl methylase  ali follow..  14  6........................................................ELAPPEIFYNDSEAHKYTGSTRVQAKMTLRALELLN---QPCSFILDIGCGSGLSGEILTQE-GDHVWCGLDISPSMLATGLSRELE------GDLMLQDMGTGIPFRAGSFDAAISISAIQWLCNADTSYNDPKQRLMRFFNTLYAALKKGGKFVAQFYPKNDD---------------QVDDILQSAKVAGFSGGLVVDDPESKKNKKYYLVLS--SGAPPQGEEQVNLDGVTMDEENVNLKKQLRQRLKGGKDKESAKSFI--------RKKELMKRRGRKVAKDSKFTGRKRRHR 274
7 -28.100[A] KOG1975 mRNA cap methyltransferase  ali follow..  13  105..................................RHEIEMTANRSINVDQIVREHYNERTIIANRAKRNLSPIIKLRNFNNAIKYMLIDKY---TKPGDVVLELGCGKGGDLRKYGAA-GISQFIGIDISNASIQEAHKRYRSMRNLDYQVVLITGDCEPFPDCRFPCDIVSTQFCLHYAEKARRALLNVAKSLKIGGHFFGTIPDSEFIRYKLNKFPKEVEKLEDAIDNVPEYVVPFETLRSLADEYGLEL---------VSQMPFNKFFVQEIPKWIERFSPKMREGLQRSD--------RYGVEGDEKEAASYFYTMFAFRKVKQYIEPESVKPN................. 436
8 -27.100[R] KOG1331 Predicted methyltransferase  ali follow..  10  2.................................................SISSENVEQEYVHSIYSRLATYQQKEHKPSSPRIWPRVRQFVDQQSAG-SIILDVGCGEAKYTS------QKSHVIGFDTCSEVLSSSKKD---------DIDLCLADAINIPIRDDSVDAILNVSVIHHLATTAQVLQECSRCLRIGGQMLIYAWAFEQSQDILVPWNMHETAIGGRLPKVKFHLNTTKEQRVIAASIPVNISDGSIPQ................................................................................................ 204
9 -26.700[R] KOG1271 Methyltransferases  ali follow..  12  2.........................................DSELNGSELGTKEFWESSYNREIRNYKSHGDVGEIWFDESAQWRTIDWLLNEIDKEASRVLDLGCGNGMFLVGLANEGFTGDLTGVDYSPKAVELAQNIAED---NKLSITYKVADLTQPQNELGQFDVVHDKGTYDAVEKRALYLDTVEKLLRTADSLFVITSCNWTEDELVDSFAE........................................................................................................................................ 186
10 -26.600[H] COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis  ali follow..  16  21........................................................KADMVAHVFHSVASK-YDVMNDLMSFGIHRLWKRFTIDCSGVQTVLDLAGGTGDLTAKFSRMVETGKVILADINDSMLKMGREKLRNI-GVIGNVEYVQANAEALPFPDNTFDCITISFGLRNVTEKEKALRSMFRVLKPGGRLLVLEFSKPIIEPLSKAYDANDADSYRYLAESIRMHPDQDTLKAMMQDAGFESV...................................................................................................... 233
11 -25.700[H] KOG1540 Ubiquinone biosynthesis methyltransferase COQ5  ali follow..  14  63........................................................KQKLVGDVFSSVANR-YDLMNDVKDHFINKLDAGKRPNSTTPLNFIDVAGGSGDIAFGLLDHAESSTMDIVDINPDMLKEGEKRAMEQYFKDPRVRFLVSNGEKLEEDSDSKDIYTVSFGIRNFTDIQKGLNTAYRVLKPGGIFYCLEFSKIENPLMDFAYQANDYDSYQYLVESIERFPDQETFKSMIEKAGFKSAGYE................................................................................................... 292
12 -23.900[R] COG4976 Predicted methyltransferase (contains TPR repeat)  ali follow..  16  98............................................EQPPSVYVERLFDDYAERFDHALVEKLGYSVPEKLAAVIGRVNGGG------RFRHVTDLGCGTGLFGERIRDRA--DFLEGFDLSANMLAKAEAKGVYDRLAQADLLAPEDSGVFGALEQRRADLVSAADVLMYLGNLEGVFVIADRLLAPGGLFAFSV-------------EDACGADGFVLRPSLRYAHPEASIASLCKESGLSMIATERTIIR.............................................................................................. 294
13 -22.700[H] KOG1270 Methyltransferases  ali follow..  12  27.................................................STSQTTVDSGEVK-TFLALAHKWWDRVPFIRDNLLKTIPNHQPGKPLLGMKILDVGCGGGLLTEPLGRLG--ASVIGIDPVDENIKTAQCHKSFDPVLDKRIEYRVCSLEEIEETAETFDAVVASEVVEHVIDLETFLQCCCQVLKPGGSLFITTINKTQLSYALGIVFSEQIAGIVPKGTH-EKFVSPETLESILESNGLSVQTVV-----MLYNPFSGYWHWSENTSLNYAAHAVKSRVQEHPASAEFVLKGET.................................................. 291
14 -22.700[IR] KOG1269 SAM-dependent methyltransferases  ali follow..  11  60....................................SEEDRARRIDGYKSVVNSYYDEYGWSQSFHFSRFYKGEAFAQSIARHEHYLAYRMG---KPGSRVLDVGCGVGGPAREITEFTG-CNLVGLNNNDYQISRCNNYAVKRNLDK-KQVFVKGDFMHMPFEDNTFDYVYAIEATVHAPSLEGVYGEIFRVLKPGGVFGVYEWVMSDDYDSSIP-KHREIAYNIEVGDGIPQMVRKCDAVEAIKKVGFN--LLEEDDLTDHDNPDLPWYYPLKLVTRYSVQFLEKIGVAAKGTSKVGDTLAIAQKGEGGETHLFTPMFLMIAKKPETDA........................ 378
15 -22.400[H] COG2227 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase  ali follow..  10  1....................................................MSNVDHAEIA-KFEALAHRWWDEFKPLHDINPLRVNWIDERAGLAGKKVLDIGCGGGILSEAMAQRG--ASVTGIDMGEAPLAVARLH---QLESGVAVDYRQITAEQMEEMPGQFDVVTCLEMLEHVPDPASVIRACHRLVKPGGQVFLSTINRNPKAYLFAVIGAEYILQLLPRGTH-RKFIRPSELGAWSREAGLEVKDII-----LTYNPLTKHYKLANDVDVNYMVQTKREA.................................................................. 232
16 -22.200[A] KOG3045 Predicted RNA methylase involved in rRNA processing  ali follow..  17  151................................................LGGRFRYINEQLYSTTSRKAEALFRKDSSAFEANPLNRIIKTIKKIPKT-AIIGDFGCGEGKLAQSVPN-----KVYSMDLVAA-----------------RSDIIACNITDTPLQARTLDVAVYCLSLMG-TDLNEFFLEANRVLKLHGTVYIAEI--------------------------QSRFQDVREFVRCLNACGFDLNKKDV.................................................................................................. 323
17 -19.500[R] KOG4300 Predicted methyltransferase  ali follow..  13  276.........................................................TEDLKRLRPPKPDWYEEFFAWSMNSEVSDYKMLFDNLVGKAEKVLEIGIGTGPNFKYYTDI-PNVSVIGIDPNAKMESYARKSATEAGLKPEEFTFVHALGESIPLEDASVDAVVGTLVLCSVTDVTQTLKEIKRILRPGGIYIF-------IEHVAAEDGTFLRLVQTVLDPLQQVVAD-RHTGESILEARFNGGADVK.................................................................................................. 472
18 -19.300[S] COG4627 Uncharacterized protein conserved in bacteria  ali follow..  12  5.....................................................................................................VVVGAGPYNNNP---------GWIHTQEE-------------------KLSLLDRSMWEKRFTPESISAILAEHVWEHLREGVEAANICYDFLKPSGYIRCAVPDGFFRDEQAVVQVGGPGPKDHPAASHKIVH-TYETISNMFKEAGFTVKLLEY.................................................................................................. 135
19 -18.400[QR] COG0500 SAM-dependent methyltransferases  ali follow..  14  74.....................................................EYFSPADICTEYAYFSSFATSWVSHA-KNYCDEITERLE---NDNSFVVEIASNDGYLLQHFLPK----PILGIEPAANVARTAIAKGVPTLVDFFGSRLA----LEMIGEGRKADLIIGNNVLAQVPDLNDFVRGMQLLLKPEGLLRWNS....................................................................................................................................................... 215
20 -18.400[S] COG1255 Uncharacterized protein conserved in archaea  ali follow..  12  2....................................................................................IEVAEFIAREVKK-GKVIEVGIGFYTIAKRLKELG---DVLAIDINKDAVVNAKNS---------GLNAEVDDIFNPNISLMGAKAIYS---IRPTPEMMNYILKISKAVKVPAYIV.......................................................................................................................................................... 105
21 -18.200[J] COG1889 Fibrillarin-like rRNA methylase  ali follow..  12  37........................................................GRRVYGERLIKWGGDEYREWNPYRSKLAAAILNGLKLVPIKETHILYLGAASGTTPSHISDIVENGLIYSVEFSPRVFREFMEKLVD--QGRRNVVPILGDARFPYQYAHYVKVDVVYIDVAQPAQAKILADNADYFLKPGGHVMLVIKAMSI-------------------DVTAPATETFKQEINTLKERGFD--ILETVHLEPYDTAHAMVIAKKR................................................................................ 235
22 -18.000[G] KOG2798 Putative trehalase  ali follow..  132...............................................FDEADVEPLKILKAQSTLKLIARDWSTEGALEREQSYKPIIDSIVAYELKDIKILVPGAGLGRLTYELACLG--YSCEGNEFSYFMLIASNDVCPLKNPPKGHFEIAAGDFLEVYKTPNAYNCVATCFFIDCANNVIDFIRTIYKILVPGGIWV-------NLGPLLYHFSDVSGQNSIE--------PAFEDLCIIMESVGFVIEKSRTGIRTKYAQNPSSMKQS------------------------------------------EYQSLFWVCRKPDLFEEQRGKRKASREPHDLIVREDSEEE 423
23 -18.000[J] KOG3420 Predicted RNA methylase  ali follow..  1.......................................................MPDKKTLWMLNEKPKIKLEQYATSSELAVSMMEMIDETIGFEGKKLIDIGCGCGMLMTTAATMYELETVLGVDIDDEALKICSRNLETAEVQD-RCELLQADILDPELPRGTFDVAVINPPFGTKNN-MQFVQIGLQMVRPGGS-VFSLHKSSTRDYILKNAKK........................................................................................................................................ 172
24 -17.700[I] COG3963 Phospholipid N-methyltransferase  ali follow..  12  1..............................................MALNLKQRLEQKFEEEIRFFKGMVSQPKKVGAISSITAKKMASVIN---HSGLPVLELGPGTGVITKAILARGKPESLTAIEYSTDFYNQLLRSYP-------GVNFVNGDAFDLDHKGQMFDSVISAVPMLNFPM-IKLLDELLKRVPHGRPVVQISYGPISPIVAQPHLYHIRH..................................................................................................................................... 178
25 -17.500[R] COG4798 Predicted methyltransferase  ali follow..  12  70.........................................................FAQVPANIAKAVADPSRPAAETARDAARRPGEILAMAELKPDTVVDYIMGGGYFTRIISGAVPQGVVYAYQPAEFIRFAARYGESLKAVTAANSKPLDGPITALDLP-DNVDAVITVQNYH--DTAAKANAEIFKSLKPGGVFL--------VIDHSA------IAGSGITAADTLHRIDIAAVKQEVEAAGFKLEA-KTDQFILKFRKPK....................................................................................... 298
26 -16.500[E] KOG2352 Predicted spermine/spermidine synthase  ali follow..  11  1..............................................MSAPNEPQSFTDPAYWKNFFAKRKSPFEWYGDY-----NSLSNVIDKYLKPKDTFLQLGCGNSELATQLYDNG--HCIHSIDVEPSVIATQIRKNKER----LGMTFETGDAANLSMADEAHTIVIDKGTLDALALVTKMFEEVHRVLASGGRYIIVTLAQPHITE............................................................................................................................................... 166
27 -15.800[R] COG2521 Predicted archaeal methyltransferase  ali follow..  17  107..............................................................................MHSVLENPLLLTSRKVERAWGRVFECCTGLGYTAIEALKK-GARHVITVEVDPHVLTLASLNPYSRGLWSPAVDVILGDCYAFTVRDSSIDFIIH--------DPPALYREFYRILKRGGGVFHYVSQSGTKYRGLNPY---------------------KGVAERLRRVGFA---------VEKIKEGYGIYARRR................................................................................ 278
28 -15.300[M] COG2230 Cyclopropane fatty acid synthase and related methyltransferases  ali follow..  12  168.........................................................................ATLAEAQLAKKRHIAAKML---KEGDKVLDIGCGWGGMGLYLARHLK-ANVTGVTLSEEQHAIANQRARDEGLAD-RAKFELTDYRNI---NDKFDRLVSVGMFEHVGHFAEYFQHVARLMKPDGVFLLHAIGRSDGPGATNPF----------IRKYIFPIPALSEVLPHIEKAGLY--VTDIEILRLHYAETLKAWREAFLANRDKAKALYDERFCRAFRWQNMMVFHIQITHRQEAVPLTRNYIEAEEKRLKRLDSAPKGANSETRSVKKSINA..... 441
29 -14.800[J] COG2813 16S RNA G1207 methylase RsmC  ali follow..  13  219....................................................................SRTGLDIGARF-------FMQHLP--ENLEGEIVDLGCGNGVIGLTLLDKNPQAKVVFVDESPMAVASSRLNVETNMPEALDRCEFMINNALSGVEPFRFNAVLCNPPFHQQHALTEMFHHARRCLKINGELY--IVANRHLHKLKKIFGNCTT..................................................................................................................................... 369
30 -14.700[J] COG2263 Predicted RNA methylase  ali follow..  13  28..............................................................................TPSPLAAEILHFAYMQGDLDESVQDLGCGTGILAIGAK-LLGARKVVGYDTDPKALEVARKNAERL---GVEVEFVCSDIKKV---SGHVKTTLMNPPF--ARVKGRDRPFLSSALRTSEV-IYSIHNRGSLAFIQKFIKPAVITHS.................................................................................................................................. 165
31 -14.700[R] COG0220 Predicted S-adenosylmethionine-dependent methyltransferase  ali follow..  15  1............................................................MRVRNRKGAGEMLAENHIVVENPADFKGRWSERFGNDHPIHIEVGCGKGAFITGMAALHPEINYIAIDMQLSVLSYALDKAIE--ADLPNVQMMLVDGAAL-FADGEIDQVYLNFSDPWPKG-KSFLATYEKILRPEGEIHFKTLFEYSLVSLANY........................................................................................................................................... 169
32 -14.400[J] KOG3191 Predicted N6-DNA-methyltransferase  ali follow..  14  41..................................................................................LIDAIEKDIKEIRRDPKLVLEIGCGSGVVSTFVNQALGNVTSVATDLNPHALDVTLET---AKLNDIKIDVVRTDFAGLENLLGKVDVLLFNLTYAGGRTLDRLLPRVPELLSPRGVFYLVALHSNDIPALLKEHSE........................................................................................................................................ 196
33 -14.000[R] KOG3115 Methyltransferase-like protein  ali follow..  3..................................ATAKKSAAQLQREEEEARKKLKRLSKQGGVEGRLPMKRLFRQRAHANVLSDHELE--DVESNKKVEIVDIGCGYGGLTVALGPQFPDTLVLGMEIRMQVSDYLKEKIQALRYRAKNISVLRMNCQKF-FEKGQLSKMFFCFPDPHFKA-STLASEYAYFIRPHGTLYTITDVEELHVWMAQHLDA........................................................................................................................................ 223
34 -13.400[R] COG4123 Predicted O-methyltransferase  ali follow..  13  2..................................................EEEQLLKSGERINQLFSTDIKIIQNREVFSYSVDSVLLSRFPRFPKK-GLIVDFCAGNGAVGLFASTRTQ-AQILSVEIQERLADMAERSV-RLNGLEEQMQVICDDLKNMPIQGSKVDMILCNARHEITTNLEEICRSAQSILKSNGRLAM-----------------------------VHRPDRLLDILDTLKRHNLAPKRLQFVYPKREKEANMLLIEAIKDGSTSGFKVLPPLIV----------------HNDDGSYTPEIEEIY.................................. 246
35 -13.400[J] COG2890 Methylase of polypeptide chain release factors  ali follow..  11  111.........................................................................DSRVLVPRSPIGELIQNRFEPTEEPTRIMDLCTGSGCIAIACANAFPEAEVDAIDISVDALNVAEQNIQDHGLEQ-QVFPIRSD----DLPQEQYDLIVTNPPYVDQEDMDSLPSEFRH--EPELGLAA---GSDGLKLARRILANAPLYLKENGILVCEVGNSMVHMMEQYPHIPFTWLEFENG................................................................................................. 290
36 -13.300[H] COG2242 Precorrin-6B methylase 2  ali follow..  13  55...............................................................................KREVRLLIISALQ---KEESIIWDIGAGTGTIPVELALLCPRSRIVAVERDEEVAGLIRRNCERFGVT--NVTVHEGSADCLPQLIAHPTHICIEGG----RPIKQILQETWAHLAPGGRLVATANNLESLYGISETLSELQ...................................................................................................................................... 189
37 -12.900[O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase  ali follow..  14  36.....................................................QYVPEAYRTLAFVDMEIPLPGGQNMLPPRVEARVLQELA---RKHEDVLEVGAGSGYMAALLAH---GRHVTTVDIAPELVAFARDNLARNG---TNVDVVQGDAGQ--WGNSLYDVICVSGSVPAVPE------SLLAQLKVGGRLS-IFVGSAPVMEAQLITRVSETE.................................................................................................................................... 191
38 -12.900[J] COG2264 Ribosomal protein L11 methylase  ali follow..  11  141...............................................................................THPTTALCLEWLDSLDLQDKTVIDFGCGSGILA-IAALKLGAKSAVGIDIDPQAILASRNNAEQNGVADR----LQLFLSEDKPADLKADVVVANIL---AGPLKELYPVIRQLVKPNGVLGLSGILATQASSVCDAYAQ........................................................................................................................................ 272
39 -12.900[R] KOG2904 Predicted methyltransferase  ali follow..  16  172.........................................................................EEGVLIPRPETELIVDMVEELVTRDEIWADLGTGSGAIAIGIAKVLSRGRVIATDLSPVAIAVAGHNVQRYSLEG-MIEVREGS-EPLKDLEGKLVGLVSNLALDGGIDLFHLCHGASRMLQPGGFFVFETNGEKQSKMIVDYMMTSDLKDCFSDLKIVSDFAGINRF.................................................................................................................. 371
40 -12.600[J] COG2519 tRNA(1-methyladenosine) methyltransferase and related methyltransferases  ali follow..  12  73..........................................................................GPQIVHPKDAALIVAYAG---SPGDFIVEAGVGSGALTLFLANIVPEGRVVSYEIREDFAKLAWENIKWAGFDD-RVTIKLKDIYE--IEEENVDHVILDLPQPE-----RVVEHAAKALKPGGFFVAYTPCSNQVMRLHEKLREFK-----------DYFMKPRTINVLVFDQEVKKECMRPRTTALVHTGYITFARRI................................................................................. 253
41 -12.300[R] COG4076 Predicted RNA methylase  ali follow..  11  9..........................................................................HGNLLGDHERLAAFREAISSRAR-GLTYDLGAGSGILSFFASEYA--DRVIAIERDPKIAACAGENLS----GLDNVSVVNEDALHYEF--SAADTIICEML----EEQVPVLRRALKFLRNDGTVI.......................................................................................................................................................... 128
42 -12.000[R] COG4262 Predicted spermidine synthase with an N-terminal membrane domain  ali follow..  240..............................................SSPYQRLVVTRWKDDLRLYINGNLQFSSRDEYRYHEA---LVLPALESVRGARRVLVLGGGDGLALRQILKYPQVEHVTLVDLDPRMTSLFSHALNQHAFSDPRVTVVNADAQWLQTAADMFDVAIVDFPDPSNFSIGKLYSVLSRHVADTGLVVIQAFAPRSYWCVDATLKEA....................................................................................................................................... 425
43 -12.000[J] KOG2539 Mitochondrial/chloroplast ribosome small subunit component  ali follow..  11  150...................................RNEVDRIMKKENFNWKPLEITTKESAAAYSLARLAPNYAEITRTLEEFNTIP-------DFQPETVLDFGSGAGAGFWAIQNKWPDKEITMVDLSDAMMKFSMDSLRNEQSSEASQNGRPFVHNNVNFLNTTYDVVLAHRVLCEIGSSETRLQLIESLWKRTNRFLILI-AFGGLLEARDFLLTQGTLV................................................................................................................................... 344
44 -11.800[O] KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase  ali follow..  13  6..........................................SAGEDNDDLIDNLKEAQYIRTERVEQAFRAIDRGDYYLEGIYSEVMEALK---QPGLSFLNLGSGTGYLSTMVGL--PFGINHGIELHSDVVEYAKEKLESFIKNSDEPAFVVGNCLQIASDSHQYDRIYCGAG---VQKDHENY--MKILLKVGGILVMPI--EDQLTQIMRT........................................................................................................................................... 201
45 -11.600[M] COG0357 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division  ali follow..  16  47...............................................................................NEMLVRHILDSIVVAPLQGERFIDVGTGPGLPGIPLSIVRPEAHFTLLDSLGKRVRFLRQVQHELKLE--NIEPVQSRVEEFP-SEPPFDGVISRA----FASLNDMVSWCHHLPGEQGRFY-ALKGQMPEDEIALL........................................................................................................................................... 176
46 -11.500[R] COG1568 Predicted methyltransferases  ali follow..  105.....................................................DLLEQFREIVKDRPEPLHQYDQAYVTPETTVARVILMHTRGDLENKEIFVLGDDDL-TSVALMLSGLPKRIAVLDIDERLIKFIEKVADELGYN--DIEIFTFDLKPLP--LHKFDTFITDPPET-IKAIRAFVGRGIATLKGPRCAGYFGITRRESSLDKW----------------------REIQRLLINEFNVVITDIIRNFNEYVNWGYAQETRAWRLIPVKKL......................................................................... 309
47 -11.400[A] KOG2793 Putative N2,N2-dimethylguanosine tRNA methyltransferase  ali follow..  15  71..................................................................................................RRGIELGTGCG-VAGMAFYLLGLTEIVLTDIAPPALKHNLKRNKTALGKSLKTSIV-NNRDQISALKPPFDLVIAADVVYIEESVGQLVTAMELLVADDGAVLLG-------YQIRSP--------------------EADKLFWELCDIVFKIEKVPHEHLHSDYAYEETDVYIFRKKVKKNEAES...................................................................... 232
48 -11.300[E] COG0421 Spermidine synthase  ali follow..  14  36......................................................LYAGKSKYQDVLVFESETYGHVLVLDGAIQEMIAHLALNSHPNPKKVLVIGGGDGGVLREVVKHECVEEAILCDIDEDVIKVSKQYLPEMSAGHPKVKVHIGDGKFLQDYQNTFDVIITDSS-------KPYFQLLSDALRGGGVITTQAIHLGVISNVLTAVKTV....................................................................................................................................... 222
49 -11.200[J] COG0030 Dimethyladenosine transferase (rRNA methylation)  ali follow..  11  14..........................................................DAEVRNTVFKFNKDFGQHILKNPLVAQGIVDKAD---KQSDTVLEVGPGTGNLTVRMLEK--ARKVIAVEMDPRMAAEITKRVQGTPKEK-KLQVVLGDV--IKTDLPYFDVCVSNTPYQISSPLVFKLLQQRPAPRAAILMFQREFA-------LRLVARPGDPLYCRLSANVQMWAHVKHIMKVGKNNFRPPPLVESSVVRIEPKNPPPPLAFEEWDGLLRIVFLRKNKTIGACFKTSS........................................................ 240
50 -11.100[A] KOG0820 Ribosomal RNA adenine dimethylase  ali follow..  10  20..........................................................RELKSAGGLMFNTGIGQHILKNPLIINSIIDKAA---RPTDVVLEVGPGTGNMTVKLLEK--AKKVVACELDPRLVAELHKRVQGTPVAS-KLQVLVGDV--LKTDLPFFDTCVANLPYQISSPFVFKLLLHRPFFRCAILMFQREFA-------LRLVAKPGDKLYCRLSINTQLLARVDHLMKVGKNNFRPPPKVESSVVRIEPKNPPPPINFQEWDGLVRITFVRKNKTLSAAFKSSA........................................................ 246
51 -10.800[R] KOG3178 Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases  ali follow..  17  174....................................................MKLFEYIQADERFGKVFNRAMLESSTMVTEKVLKFYEGFKDVK----TLVDVGGGLGNTLGLITSKYPHLIGINFDLAPVL---------ANAHSYPGVNHVAGDMIKIP----KGDAIFMKWILHWTDE--AILKNCWKSLEENGIIVEMVTPVEAKSGDICSNIVFGMDMTMLTQCSGGKERDLYEFENLAYASGFSRCAI------VCAVYPFSVIEIYK................................................................................ 378
52 -10.700[R] COG2384 Predicted SAM-dependent methyltransferase  ali follow..  5.................................................................................KLSKRL-KAVANYVDNGARLADIGSDHAYLPTYLMQKLVIDFAVAGEVVKGPFEIAKNHVSEADLSDRIEVRLANGLGAIENTDKIDTIVIAGM---------------------GGILISEILGKEKLGHVKRLI--------------LQPNNHEESLRQWLVNHQFV---IKKEEILLEAGKFYEIIVAEPLSKLMTEKLSVNDLTFGPFLSKEKSTVFQQKWQKE-------TLNKIIARLPEEQAEKRQEVLNQIARIEEVLR...... 230
53 -10.700[V] COG3510 Cephalosporin hydroxylase  ali follow..  11  70..................................................................................NYQEILSEL-----QPSLVIEFGTRYGYFANIMRQIGQPFKVLTVDNSHKALDPRARREPLFVESSSTDPAIAEQIQRLKNEYPGKIFAILDSD-HSMNHVLAEMKLLRPLLSAGDYLV--------VEDSNINGHPVLPGFGPGPYEAIEAYEDEF-------PNDYKHDAERENKFGWTSAPNGFLIRN.................................................................................. 245
54 -10.700[R] KOG2920 Predicted methyltransferase  ali follow..  11  170.................................................................................ECTFDLLAYFTKAKVKFKKVLDLGCGSG-LLGITAFKGGSKEIHFQDYNSMVIDEVKRCRKPKVTQLYKCRFFSGEVLSSEKLFVKYDLILTSETIYNPDYYSNLHQTFLRLLSKNGRVLLAS-----------------KAHYFGVGGGVHLFQK------FVEERDVFKTRILKIIDEGLKRFIIEI--TFKFPG............................................................................. 372
55 -10.600[J] COG5459 Predicted rRNA methylase  ali follow..  89...................................NNNIMAVHIPNNLRRVATNYYKEIQEPNSLHRPCRTKMEVDAHIAFQSLKELQKRVGPDNFKPQRILDVGYGPATGIVALNDILGPNERAKIILSRQLNEVVDTVEENVSTEKEQETDRRNKNFQ---ASKEYDLIILTHQLQFPIQVDENIEHYLNILAPGGHIVINPMGFEIIARARQITLRPENF.................................................................................................................................... 333
56 -10.500[L] COG1041 Predicted DNA modification methylase  ali follow..  12  142......................................................IREFKGKEFEDRKADRRPFSRPIALPPRIARAMVN----LTKATREVLDPFMGTGGM--LIEAGLIGLKVYGLDIREDMVEGAKINLEYYGIRDYVV--KVGDATKIEFPGKTFEAVATDPPY-----YKRSLESIHSVLEGRLAIA---------------------------------FPADFDARDVAESIGFKVLGRFYQRVHSSLSRYFYVME................................................................................... 328
57 -10.500[J] COG1189 Predicted rRNA methylase  ali follow..  12  12.....................................................ERYDKPGQKIDDGTELRLKGEKLRYVSR--GLKLEKALKEFHLEINTCLDIGSSTGGFTDVMLQN-GAKLVYALDVGTNQLAKIRSDERVVVMEQFNFRNAVLAD----FEQGRPSFTSIDVSF----SLDLILPPLYEILEKNGEVA-------ALIKPQFEAGREQVGKNGIIRDPKVHQMTIEKVLKTATQLGFSVKGLTFSPIKGGAGNVEFLVHLLKDGKAEIAQQVNIESVLQKESEEL......................................................... 243
58 -10.500[J] KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14  ali follow..  226..........................................................................GTAITFPKDINMILSMMD---NPGDTVLEAGSGSGGMSLFLSKAGSQGRVISFEVRKDHHDLAKKNYKHWRDSWDNVDFIHKDISG--IKSLTFDAVALDMLNPH-----VTLPVFYPHLKHGGVCAVYV---VNITQVIELLDGIRTC---------LALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQ................................................................... 433
59 -10.400[D] KOG4589 Cell division protein FtsJ  ali follow..  12  3...........................................STKKSQGNLHKYIQRQSTDEFAVKAREHNYRARSAFK-----EINEKFKFLKPE-STVIDIGCAPGSWLQVVVQKCPNGYASGVDLQNVLPIRGADILSLSDITDPAVKLKIREK----LAHRQVDVVLSDMAPNPTGDFRLFSVENEIELVKNGVYLCKIWDGSARAEFVRELSD........................................................................................................................................ 185
60 -10.200[R] COG4122 Predicted O-methyltransferase  ali follow..  11  31..................................................................RQETALQPMGRMQIAPEQGQFMALLVQL-LGAKKTLEVGVFTGYSSLIVALALPAGKLVACDINEEFTAIAQRYWQKAGVDHKIDLYLAPALETLD-EAETFDFAFIDAD----SNYDNYYERSLQLIRSGGVIAI----DNVLWSGKVADPEIQDNRTQKIRAFNHKLLQDQRITLSLIPIG.......................................................................................................... 211
61 -10.200[E] KOG1562 Spermidine synthase  ali follow..  16  56......................................................LFHEKSKYQDVLVFESTTYGNVLVLDGIVQEMLAHLPMFAHPDPKRVLIIGGGDGGILREVLKHESVEKVTMCEIDEMVIDVAKKFLPGMSCGHPKLDLFCGDGEFLKNHKNEFDVIITDSS-------QSYYELLRDALKEDGILSSQGLDMKLISTVIHSARDL....................................................................................................................................... 242
62 -10.200[OKT] KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes  ali follow..  16  222......................................................................ESYAGNDIHFLMLNDSVRDFVYHNKHIFATVLDVGCGTGILS-MFCAKAGAKKVYAVDNSD--IIQMAISNAFENGLADQITFIRGKIEDISLPVGKVDIIISGYALTFESMIDSVLVARDRFLAPSGIMALTATTNTELLEEPIDFKMNGMKDASYKGVSVQVVPQTYVNAKPVVFARFNMHTCKVQDVSFTSPFSLIIDNEGPLCA............................................................................. 450
63 -10.200[R] COG2933 Predicted SAM-dependent methyltransferase  ali follow..  186................................................................................SRSTLKLEEAFHVFIPADEWAVDLGACPGGWTYQLVKR---MWVYSVDNGP---------MAQSLMDTGQVTWLREDGFKFRPTRSNISWMVCDMVEKPAKVAALMAQWLVNGWCRETIFNLKLPMKKRYEEVSHNLAYIQAQLD.................................................................................................................................. 328
64 -9.920[Q] KOG1663 O-methyltransferase  ali follow..  10  49.....................................................SVYPREPESMKELREVTAKHPWNIMTTSADEGQFLNMLIKL-VNAKNTMEIGVYTGYSLLATALALPEGKILAMDVNRENYELGLPIIEKAGVAH-KIDFREGPAPVLD-NHGTYDFIFVDAD----DNYINYHKRLIDLVKIGGVIGYTLWNGSVVAPPDAPMRKYVRYYRDFVLELNKALAADPRIEICMLPVG.......................................................................................................... 249
65 -9.860[R] KOG2497 Predicted methyltransferase  ali follow..  11  127...............................................PRSRKLVIPLHCSLNMLEGDTGCSIWPSSLFL----SEFVLSFPELFA---KACFEVGSGVG-MVGICLAHVKAKEVILTDGDLLTLSNMKLNLERNHLNYDDEFLKQETASESELSQYRPDIVLGADVIYDPSCLPHLLRVLVALLKNPPKRGNGSL----ETEDRDTTQEEHSPAVAYIASVIRNVDTFNVCLTLADQMDLSITDVTAEL................................................................................................ 343
66 -9.520[DR] KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ  ali follow..  13  1....................................................MGKASRDKRDIYYRKAKEEGWRARSAFK-----QIDEEFNIFEGV-KRVVDLCAAPGSWSQVLSRQLYLPAIVAIDLQP-------------MAPIEGVIQVQGDITN--FDGCKADLVVCDGAFVQSQLILAGLTIVTHILKEGGKFIAKIFRGKDTSLLCQAFAVCE...................................................................................................................................... 185
67 -9.470[R] COG3897 Predicted methyltransferase  ali follow..  13  63..................................................................................LARYILDHPESVC---KRVLDFASGSG-LVAIAAAKAGAAKVLAADIDPWTETAIRLN---AALNGVDIGFTGLDLVG---KPVDADVLLAGDVFYDRAFADLLVPWFVELTEKGMIVLVGDPGRAYLPK............................................................................................................................................... 183
68 -9.460[L] KOG2671 Putative RNA methylase  ali follow..  182........................................................DRKLLPTF--QLKSRTYLGPTAMDAEMAFLMAN-QAKATSG-KLVYDPFVGTGSI--LVSAARFGAMTMGADIDIRVVRDGRGPDCNVWSNPMPVALLRMDNNVPPWRKEIFDAIICDPPYSLVECVHDLLHLAARMLVMKGRLVFFF-------------------------------DETGSEVKFPEHPCFKLVAVSEQILSSRYSRVLLTMVKVEPYSEEVEEAARLM--------------------------LEFRENHLKWLEDGNIHSSIFKPIDSSQIDTDSKAFKDPKP 470

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Godzik A. Surface map comparison: studying function diversity of homologous proteins. J Mol Biol. 2001 Jun 8;309(3):793-806.