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Query: [KB] KOG3265 Histone chaperone involved in gene silencing, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MASRVNIVQVQILDNPAMFVDKFKMEITFEVFEHLPHDLEWELVYVGSGTSRDFDQVLDSALVGPIPEGRHKFVFDAEHPDISKIPVEDIVGVSVLLLRCKYNDQEFINMGWFVANEYTDEELKENPPAKPLIEKVLFFSGKKHFISKHQLLSNDSPFLIVRTVFVESNKALHLTSNEDDCSGNYKTCINNSSDSFVENLSRKIETEDLRVTTFPIRWTDEDPVAEPVDEEANKVFDEDDLMPLHDDGQDDDEEEEDDDETGPNTEEVDLNESFNERMANAHDGTEQKNGEESMEHDGASGDVEMGDNQLFVQINTDTKATESMVDPLSDTTKRDFRSGLast
1 -72.200[KB] KOG3265 Histone chaperone involved in gene silencing  ali  100  1MASRVNIVQVQILDNPAMFVDKFKMEITFEVFEHLPHDLEWELVYVGSGTSRDFDQVLDSALVGPIPEGRHKFVFDAEHPDISKIPVEDIVGVSVLLLRCKYNDQEFINMGWFVANEYTDEELKENPPAKPLIEKVLFFSGKKHFISKHQLLSNDSPFLIVRTVFVESNKALHLTSNEDDCSGNYKTCINNSSDSFVENLSRKIETEDLRVTTFPIRWTDEDPVAEPVDEEANKVFDEDDLMPLHDDGQDDDEEEEDDDETGPNTEEVDLNESFNERMANAHDGTEQKNGEESMEHDGASGDVEMGDNQLFVQINTDTKATESMVDPLSDTTKRDFRSG 339
2 -51.600[KB] COG5137 Histone chaperone involved in gene silencing  ali follow..  32  1.MSIVNILSVNVLNNPAKFSDPYKFEITFECLEPLKSDLEWKLTYVGSATSQSYDQILDTLLVGPIPIGINKFVFEADPPNIDLLPQSDVLGVTVILLSCAYEDNEFVRVGYYVNNEMEGLNLQEMDDAEI------------------------------KKVKVDISKVWRSILAEKPRVTRFNIQWDNPDFDDAPPVQPDADEEEEEEEADEMEEEFDEEGEGDEEEEEEDDGDGDGEGDGDGEGENDGKGSEEEEEEEIDIEEEEEESALANASAAEEKPEEKPETSQ............................................... 262
3 -16.200[K] KOG2478 Putative RNA polymerase II regulator  ali follow..  6  358.................................................................................................................................................................EKELEAQEARKAQLENHEPEEEEEEEMETEEKEAGGSDEEQEKGSSSEKEGSEDEHSGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQAQGGSDNDSDSGSNGGGQRSRSHSRSASPFPSGSEHSAQEDGSEAAASDSSEADSDSD.... 531
4 -14.800[S] KOG4610 Uncharacterized conserved protein  ali follow..  11  172.........................DLTRDQLSQL-------LVYIGTAAD-AKIGFLVFLTLGIWSWSLMQFTIVLSATRGRRPRGS--IDVWGIVLNVILQDAPFLTFRLLIIFQYKIIN-KNSLVIILQLYRLYVVNAEFWKNRRESRMAKSRQFQSRRKVQDADQNSIYMISNERGGDVKKKIKRAKDKDYAEQEAVYSKKKKDKKDKKKRKRKDTGYSTASSQNLYSTKASGTDKDTRRKDKKGKKSKRTCSSSPSDCDLAKKQKRKNADKNDKKKSRKIEAVVEESSSSSSSSSDSSNSTLPSYEVIDEKKARRRKHRGSSSDTSSGDSSSSS 514
5 -14.100[R] KOG2295 C2H2 Zn-finger protein  ali follow..  6  269......................................................................................................................EDLKVLDEKPKDPVVYERKAEQMQSVKEVEKTINSPKEEMSEADPVSTQRKPVRPVNSDGENWDDDDAENSAPKKELAEDSKDSDSKPEDKQLNKKKTKKRKRNSSDDDSSSSESSSSSDEEKLKEKYDVEDGLRAEQKTEAEKDRQEATKAKQGPQSPKLDEDEGNENTEPKGLDSKINTYEEIDNTLKSPEISSNPIKNTDNGDGSKVEEDGEKPSVG. 488
6 -13.400[R] KOG4334 Uncharacterized conserved protein, contains double-stranded RNA-binding motif and WW domain  ali follow..  7  2.......................................................................................................................................................................................EQESGGKKSNEQLLSEREAIMRQLAMLGSGPEDLDVDDEEEDEEEEVEKMEEGVEETMENASVVKETTPVKDENIVEDSNSSEELFPYLDSPPEDKIQEISANDTEIDQIDSPIRFEGVKNPAQKMDVDGEEGTSTDARPVSGSSGSSVGEQIRA. 156
7 -11.900[R] KOG4264 Nucleo-cytoplasmic protein MLN51  ali follow..  9  3..................................................................................................................................................................DRRRQRASQDTEDEESGASGSDSGGSPLRGGGSCSGSAGGGGSGSLPSQRGGRTGALHLRRVESGGAKSAEESECESEDGIEGDAVLSDYESAEDSEGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKN. 178
8 -11.000[A] KOG4849 mRNA cleavage factor I subunit/CPSF subunit  ali follow..  9  515.........................................................................................................................................................EAKSYNRRERSRSRERSHRSRQRRERSTSRYRERSRERERDRDRERERDGGRSVRPRKSPEPVVAEAAEAPSSKRYYEDRERYRSSDRERRDRDRDRDRERERDRDRHFTNDGRGLPLDPSNFTSQNPGNIKTGRPKSAAVAGGSMEKPRGQSAWDIIDTDAHWIIKQQTTSIPAPPSSQQN.... 696
9 -11.000[S] COG5604 Uncharacterized conserved protein  ali follow..  8  6...................................................................................................................................................................SIIKARKANALAKKNDKIKKKDTDKGIRQKHSKKEGKDETLKRDVEKFIQNVNSEDTPSEDDSMSMDAFLEGGFEELDSANSNDAGSSRKRKNLPNENTQDSTSESSEEEEDGLESYQKQLEGLKEKDPEFYKFLEQNDQDLLEFNAAETDAMAKEIDENERLKSSSGKIVLTSD. 180
10 -11.000[J] KOG2256 Predicted protein involved in nuclear export of pre-ribosomes  ali follow..  8  6...................................................................................................................................................................SIIKARKANALAKKNDKIKKKDTDKGIRQKHSKKEGKDETLKRDVEKFIQNVNSEDTPSEDDSMSMDAFLEGGFEELDSANSNDAGSSRKRKNLPNENTQDSTSESSEEEEDGLESYQKQLEGLKEKDPEFYKFLEQNDQDLLEFNAAETDAMAKEIDENERLKSSSGKIVLTSD. 180
11 -10.900[J] KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis  ali follow..  9  2.....................................................................................................................................................................................TKKLALKRRGKDSEPTNEVVASSEASENEEEEEDLLQAVKDPGEDSTDDEGIDQEYHSDSSEELQFESDEEGNYLGRKQSSSAEEDEESSDEEDNEEEESTDGEEVEDEEKDSKSKQTDDKPSGSGAASKKALTAELPKRDSSKPEYQDSDTSDEED. 158
12 -10.900[K] KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit  ali follow..  11  403.................................................................................................................................................................................................PEPGFEDVFKSIQEEFERSEKTRIQKDALQPSQRNHQETTKDMKKCKNTNKEKDDDVNADEDSEDLDDEYEEAANDDDISISSHGYGDMENNSRTYLQGLFNRFPSSASALYGSANDDNDSDGEYPIYEQESNALDDDEEDDE... 545
13 -10.900[K] KOG2393 Transcription initiation factor IIF, large subunit (RAP74)  ali follow..  11  197.............................................................................................................................................................NNGPALFGEVDNEKESGGTSGGGGRGRKKSSGGDEEEGNVSDRGDEDEEEEASRKSRLGLNRKSNDDDDEEGPRGGDLDMDDDDIEKGDDWEHEEIFTDDDEAVGNDPEEREDLLAPEIPAPPEIKQDEDDEENEEEEGGLSKSGKELKKLLGKANGLDESDEDDDDDSDDEEETNYGTVT. 377
14 -10.800[KU] KOG2773 Apoptosis antagonizing transcription factor/protein transport protein  ali follow..  9  29.........................................................................................................................................................AEDSDFDVATGPRLVDFEEEEYDLPDARSTDFRKRNVKLLSEQSDRYKGKISSRKELDDDEDKDDEQEVSYEESDEDDENLTNFKQKLNAGGAEDSEEETAAGHSESGEESEEIESNLTDFKKKFEAGDFKYDDDEEEDDDSEEEDHSQESEGDDDDSEDDEAEDDAIKPSDVMSKTNHQAEIQKG 214
15 -10.400[J] COG5593 Nucleic-acid-binding protein possibly involved in ribosomal biogenesis  ali follow..  12  699..................................................................................................................................................................................NDKYIKGKQARKTKVDRDEEGEIDEDEVWKALVDSKPQLEMDEEESDFDSEEMDKAMTDMGSDSEQSADENDNESMASEEKPMFSDEENLSEIAHSEDEFDDTVDFFEDENDLLPFNETDDEEEIQTVDHSETHSHKKKKRKAIKDLPVFADAES...... 853
16 -10.100[S] COG4392 Predicted membrane protein  ali follow..  12  1.MVWAVIFGMGAIVFLNRY-----LFLEPRLPIRLGSNLRQFLGFAVPG-------MLTAICGPIVFMPEGRIDLGYDNPY--------LVSGAVTVALVLYTRNTLASM..................................................................................................................................................................................................................................... 89
17 -9.950[A] KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain  ali follow..  4  7.........................................................................................................................................KVNELREELQRRGLDTRGLKTELAERLQAALEAEEPDDERELDADDEPGRPGHINEEVETEGGSELEGTAQPPPPGLQPHAEPGGYSGPDGHYAMDNITRQNQFYDTQVIKQENESGYERRPLEMEQQQAYRPEMKTEMKQGAPTSFLPPEASQLKPDRQQFQSRKRPYEENRGRGYFEHREDRRGRSPQPPAEEDEDDFD. 207
18 -9.820[K] COG5164 Transcription elongation factor  ali follow..  9  1...........................................................................................................................................MSDNSDTNVSMQDHDQQFADPVVVPQSTDTKDENTSDKDTVDSGNVTTTESTERAESTSNIPPLDGEEKEAKSEPQQPEDNAETAATEQVSSSNGPATDDAQATLNTDSSEANEIVKKEEGSDERKRPREEDTKNSDGDTKDEGDNKDEDDDEDDDDDDDDEDDDDEAPTKRRRQDIEAEVSDDEDEDEDEEDSELVREG 206
19 -9.730[A] KOG4676 Splicing factor, arginine/serine-rich  ali follow..  9  308.................................................................................................................................................................SKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDMDMSD. 484
20 -9.560[R] KOG1400 Predicted ATP-dependent protease PIL, contains LON domain  ali follow..  6  1......................................................................................................................................................MDEEENSEINSVQARDEDVQLEDQQSQGLQDRQVDVIEQAWNNAMPDEPSPPAEDAFQDPLATDGEGGDALEAMVENVLQDDTASEGSHPSSDMSLESPGSEDDSDLESLPHWMIPQNRLRSAVDMMVSQARNRDGGIAALLSGDNFLQRVRSMVFSQERRRSRTSEETSQEAAEQPVDPPPQQPPRP. 188
21 -9.550[S] COG5291 Predicted membrane protein  ali follow..  9  212..........................................................................................................................................................................................................NEHPSSCCKARKGITIREGRERHERNMGYSNASTTSGDSMASLTDMADTKSSTENSAVTEESQCCAESFKDSSVVSSQKSMAVSTVVGSSTEAKNNYLDFTEALCDKEVVAEQNPESQSNEEWDEKWGDSDNESECS 348
22 -9.540[B] KOG2266 Chromatin-associated protein Dek and related proteins, contains SAP DNA binding domain  ali follow..  10  2.................................................................................................................................................................GEDTKATIEPTANKTTSLEKPSEAMAGKENAGGKETQELAKDEDMAEPDNMEIDAQIKKDDEKAETEDKESEVKKNEDNAETQKMEEKVEVTKDEGQAEATNMDEDADGKKEQTDDGVSVEDTVMKENVESKDNNYAKDDEKETKETDITEADHKKAGKEDIQHEADKANGTKDGNT. 178
23 -9.310[C] KOG4669 NADH dehydrogenase subunit 4L and related proteins  ali follow..  11  1MIDHVYQMPLLAISLLGILVYRSHLVSSLLCLEGIILSIVIINTLTALSIHFTLAPIIPIILL----------VFAP----------EAAVGFALLVSISNTYGLDYVQ...................................................................................................................................................................................................................................... 92
24 -9.170[J] KOG2147 Nucleolar protein involved in 40S ribosome biogenesis  ali follow..  8  158.......................................................................................................................EKTAEEHVREKISREDMISNLIAKTKLARHEKQQQKDELELMTESLDSKYQALMGKMKASFRPTGRQPLEKDDYDKLTITLKTEADARATPADRKLSEEEEALKEKERLETLEAAPDADVDIDAGSKADARKVQAKNSRFEVKFDDEGGLIDEDTVEKSRILKKNLDGSDESDDDEDLEDEEEDLDDLLEDEDELEEDSDDEEAQEAQKVVKKAKKSAPE 377
FFAS is supported by the NIH grant R01-GM087218-01
1 4 8 3 2 2   jobs submitted since Jan 1, 2011
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Reed JC, Doctor K, Rojas A, Zapata JM, Stehlik C, Fiorentino L, Damiano J, Roth W, Matsuzawa S, Newman R, Takayama S, Marusawa H, Xu F, Salvesen G, Godzik A.; RIKEN GER Group; GSL Members. Comparative analysis of apoptosis and inflammation genes of mice and humans. Genome Res. 2003 Jun;13(6B):1376-88.