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Query: [R] KOG3529 Radixin, moesin and related proteins of the ERM family, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSKKAINVRVTSMDSELEFAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYTDNKGFPTWLKLNKKVLSQDVKKDPTLVFKFRAKFYPEDVAEEIIQDVTMRLFYLQVKDGILSDEIYCPPETSVLLASYAMQAKYGDYVPETHVAGCLTADRLLPQRVLGQFKLNSEEWERRIMTWWADHRATTREQAMLEYLKIAQDLEMYGVNYFEIRNKKGTDLYLGVDALGLNIYDKADRLSPKVGFPWSEIRNISFNDKKFVIKPIDKKAHDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKQQAREDRALKIAEQEKLTREMSAREEAEQRQRDAEKRMAQMQEDMERARLELAEAHNTIHSLEAQLKQLQLAKQALEQKEYELRELTAQLQSEKAMSDGERRHLRDQVDAREREVFSMREEVERQTTVTRQLQTQIHSQQHTQHYSNSHHVSNGHAHDETATDDEDNGATELTNDADQNVPQHELERVTAAEKNIQIKNKLDMLTRELDSVKDQNAVTDYDVLHMENKKAGRDKYKTLRQIRGGNTKRRIDQYENMLast
1 -130.000[R] KOG3529 Radixin, moesin and related proteins of the ERM family  ali  100  1MSKKAINVRVTSMDSELEFAIQSSTTGKQLFDQVVKTIGLREIWYFGLQYTDNKGFPTWLKLNKKVLSQDVKKDPTLVFKFRAKFYPEDVAEEIIQDVTMRLFYLQVKDGILSDEIYCPPETSVLLASYAMQAKYGDYVPETHVAGCLTADRLLPQRVLGQFKLNSEEWERRIMTWWADHRATTREQAMLEYLKIAQDLEMYGVNYFEIRNKKGTDLYLGVDALGLNIYDKADRLSPKVGFPWSEIRNISFNDKKFVIKPIDKKAHDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKQQAREDRALKIAEQEKLTREMSAREEAEQRQRDAEKRMAQMQEDMERARLELAEAHNTIHSLEAQLKQLQLAKQALEQKEYELRELTAQLQSEKAMSDGERRHLRDQVDAREREVFSMREEVERQTTVTRQLQTQIHSQQHTQHYSNSHHVSNGHAHDETATDDEDNGATELTNDADQNVPQHELERVTAAEKNIQIKNKLDMLTRELDSVKDQNAVTDYDVLHMENKKAGRDKYKTLRQIRGGNTKRRIDQYENM 563
2 -96.800[R] KOG3530 FERM domain protein EHM2  ali follow..  17  8.GNIVYKCTVRLLDDSLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC-KEMDPLLFSLRVKFYPADPFR-LTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGDYNEDVHVGSYVSSIELALR--------QTECLEKKIIELHKKEPGQNLSLAMDEFLGIARGLETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQ---HFRWNEIHKINFEGKMFIAHLSYTKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGFFSWGTKFRYTGRTEREILTENINALREQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPNGHFYGHDHGMSDANGGIQISSLEPVCEEARLRSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTVNGYDHPRKHNEARQHGSYSPNLYYGQSDGAVNSSSPADSFLHADPSTRKVKKFRKFH.......................................................... 508
3 -16.100[T] KOG4335 FERM domain-containing protein KRIT1  ali follow..  17  278........................................................RDWPEILAELTNLDPQRETPQLFLRRDVRLPLEVEKQIEDPLAILILFDEARYNLLKGFYTAPDAKLITLASLLLQIVYGNYESKKHKQGFLNEENIVPVTKLKS---KAPHWTNRILHEYKNLSSKEMHHLQRMFLQNCWEIPTYGAAFFTGQNHKVIPVYVGVNIKGLHLLNMETK--KYGCFMW------QLGDTDTCFQIHSENKMSFIVHTKQAGLVVKLLMKLNGQ................................................................................................................................................................................................................................................................................... 521
4 -7.280[T] KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family  ali follow..  11  39.SGDLVALKMVKMEPDDDVS---TLQKEILILKTCRHANIVA--YHGSYLWLQK----W------ICMEFCGAGSLQDIYQVTGSLSELQISYVCREVLQGLAYLHIHRDIKGANILINDAGEVRLADFGISAQIGATLARRLS----TPYWMAPE--------------------------VAAVALKGGY----ELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRL-KWSA----AFHN--FIKVTLTKSPK-------KRPSATKMLS-----HQLVSQPGLNRGLILDLLDKLKNPGKGPSIGDIEDEEPELPPAIPRRIRSTHRSSSLGIPDADCCRRHMEFRKLRGMETRPPANTARLQPPRDLRSSSPRKQLSESSDDDYDDVDIPTPAEDTPPPLPPKPKFRSPSDEGPGSMGDDGQLSPGVLVRCASGPPPNSPRPGPPPSTSSPHLTAHSEPSLWNPPSRELDKPPLLPPKKEKMKRKGCALLVKL....................................................... 490
5 -6.920[T] KOG0582 Ste20-like serine/threonine protein kinase  ali follow..  38.LNVVVAIKVLDLE-----------KCNNDLDGIRREVQTMSLQAHC-SFT--TGHQLWVVMPLHIIKSSYPDG-----------FEEPVIATLLRETLKALVYLHIHRDVKAGNILLDSNGAVKLADFGVSACMFDTGDRQRSRNTFTPCWMAPE----------------------------------------------------MQQLHGYDFKADVWSFGITALELAHGHAPFSKYPPMKVLLMTLQNAPPGLDYERDKRFSKAF--------KEMVGTCLVKHPFFKHARPADYLVKTILNGLPPLGDRYRQIKSKEADLLMQNKSEYEAHLSQARISTFCLIQEYIRGISAEDLKTQAALISDDDTSHAEEPDFNQKQCERQDESALSPERASSSATAPSQDDELNDIHDLESSFASFPIKPLQALKGCFDISEDEDNATTPDWKDANVNSGQQLLTKASIGSLAETTKEEDTAAQNTSLPRHVISEQKKYLSGSIIPESTFSPKRITSDADREFQQRRYQTERSYSGSLYRTKRDSVDETSEVPHVEHKGRFK.. 551
6 -6.750[T] KOG3537 Adaptor protein NUMB  ali follow..  11  62...................................................ESSKPHQWQADEEAVRSA--------TCSFSVKY----------------------------------------LGCVEVFESRGM-----------------------------QVCEEAL-----------------------KVLR--------QSRRRPVRGLLHVSGDGLRVVDDETK----------TIEKVSF------CAPDRNHERGFSYICRDGTTRRWM---C---HGFLACKDSGERL----SHAVGCAFAVCLERKQRRDKECGVTMTFDTKNSTFTRTGSFRQQTLTERLAMATVGTNERSVDGPGSAMPGPPAATVKPFNPFAIERPHATPNMLERQSSFRLSTIGSQSPFKRQMSLRINDLPSNADRQRAFLTAAAGNPMQTP................................................................................................................. 332
7 -6.690[S] KOG2103 Uncharacterized conserved protein  ali follow..  10  700VTPEESSLVVYLIDT---------ITGRILHRLSHQGCQVFSENWVVYHYFNLRAHKYEVLGKHNLTAPITSYSRPEVFTKSQSYFFAQSVKTIAVTSTAK---ITSKQLLIGDQI-------LALDKRFVDPR--NPSQAEKEEGIIPLTDTLPII------------PQAYVTHSHKVEGLRGIVTAPSKLESTTHVFAYGVDLF-------------------------TRLAPSKTY---DSLTDDFSYALLLITIV------ITWVLSEKKELSEKWR........................................................................................................................................................................................................................................................................................ 955
8 -6.310[S] COG4036 Predicted membrane protein  ali follow..  15  11....................................................................................FTVPEKC-MMVPEFTLSLFQPAIYTGLIAGFIALLGISIVGIAMLVIVAAVGT----------LAEALILPGLVVELAEI-SEILISREMRILGEVPVVEHRPMELEVFRTAPNLIAYGVFLTGFTGG-------AVAGAGILFYVATRRARGLPTVEWDGIAGISGVTWCLWL---------AGFLI----TAPQLWLPAL-------------MSGCGILIKVASKMGLIGVLAREEIREA............................................................................................................................................................................................................................................ 237
9 -6.310[S] COG4457 Uncharacterized protein conserved in bacteria, putative virulence factor  ali follow..  20.........IQFLDFALTPESDTELPNKFV--PLEQSLKLLNQIWLPLPFLRFTGPDNWARV--QILTLDTPDQDGNTLRVTLAF-----DTKVYPESHDNDYLAPTENDIKTGLSFALAYHNEDLAEFLDLTWVDGWLRDEYQAHYLNVLALLPEIKITTNTLQEPAVNDLILDV-----GNSHTCGIL--LNQTYELQLRDLSKPHYLYNALFESRVEFAQAKFGQQSFSVESGREDAFIWPSITRVGHEACRMALQRLGTEGSTG---ISSPR--RYLWDEESYAAGWRFSGTPTAPHEELATALPLTLLLNDDGEPLYRLPAEERLPVFSPHYSRSS.............................................................................................................................................................................................................................. 416
10 -6.050[F] KOG2070 Guanine nucleotide exchange factor  ali follow..  240...................GFDTTAINKSYYNVVLQNILETENEYS-LQTV----LSTYL---RPLQTSEKLSSANISYLM--EIC--SFQQMLVQSLEECTCFLNLMPQMKT-LTYCAPSAVNVLTEH--SEELGEFMETKGAS--LTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLEVRKRKEL------AIRNWEGDD----IKTLGNVTYMSQVLINERYLLLFPNVLLMLYQGKRNAFEISGSMIERILVSCNNQQD-LQEWVEHLQK----TKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN............................................ 782

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Robinson-Rechavi M, Godzik A. Structural Genomics of Thermotoga maritima Proteins Shows that Contact Order Is a Major Determinant of Protein Thermostability. Structure (Camb). 2005 Jun;13(6):857-60.