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Query: [Q] KOG3626 Organic anion transporter, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MERIYIFLGLFSFVFFLEAIGGSYINSAVQNIERQFQMSSRTSGFMISASDFGYIPCVVFIAHFGSKGNRARWIGAGAILVSITYLMLASPNFLFPQGHHDINTTEVSAKLKPTAGQLASNSTLKQLLSYQLIRDRMPHDTYMSLINLEDDTTPIEEYQPIGRPPKIGQGQSGNSTYTIDGWLFNEALVAAENLIANNTSQNTLRSSLSLFIHRRTNTSTKDIQKIRISAAAPFTFCGKLTNSLRAVIKDSKCKEQTSNSYPFLVFFFSLLLLGIGRTVPWSLGVPLLDDNIKKKSLPAYFGAISSIRVLGPICGYMIGSFCNKFYYTLNPPNGLTPADPTWIGAWWMGFLFIGSIALFPSTMLFFFPQGKEGDGSAVQLRDVHKEKLKKSVDEDRTITMKLKDFAKSCKKVLSTKIYMGSVLGRVCDVLAFKGYIVFLPKYLENHFGIPQYLVHRYMAMFGVFGFGLGVATGGYVTKKLKLNGRRAAMFVMLMSTLNVCLYSGKIFIGCESIVNSIGSNNRQTNYNFTRECNSQCSCENARLYPVCDQTGFAYFSPCHAGCREAMQYGSDPVLDFTSCQCAPGGVVSKKFCENTCKTSSVIFFLTVLPGSFVAGLGVVPAMLILLRSVPPETRSLSLGLQGMAVSLFGTLPSPILWGLVIDAACLVWDKACNGARGSCSIYHPDRLRVWMHLLYVVIRTVALITDVYVWKHAKNLNIMDEPVSEEKDNIRRNSIKMQAVQPDQLast
1 -207.000[Q] KOG3626 Organic anion transporter  ali  100  1MERIYIFLGLFSFVFFLEAIGGSYINSAVQNIERQFQMSSRTSGFMISASDFGYIPCVVFIAHFGSKGNRARWIGAGAILVSITYLMLASPNFLFPQGHHDINTTEVSAKLKPTAGQLASNSTLKQLLSYQLIRDRMPHDTYMSLINLEDDTTPIEEYQPIGRPPKIGQGQSGNSTYTIDGWLFNEALVAAENLIANNTSQNTLRSSLSLFIHRRTNTSTKDIQKIRISAAAPFTFCGKLTNSLRAVIKDSKCKEQTSNSYPFLVFFFSLLLLGIGRTVPWSLGVPLLDDNIKKKSLPAYFGAISSIRVLGPICGYMIGSFCNKFYYTLNPPNGLTPADPTWIGAWWMGFLFIGSIALFPSTMLFFFPQGKEGDGSAVQLRDVHKEKLKKSVDEDRTITMKLKDFAKSCKKVLSTKIYMGSVLGRVCDVLAFKGYIVFLPKYLENHFGIPQYLVHRYMAMFGVFGFGLGVATGGYVTKKLKLNGRRAAMFVMLMSTLNVCLYSGKIFIGCESIVNSIGSNNRQTNYNFTRECNSQCSCENARLYPVCDQTGFAYFSPCHAGCREAMQYGSDPVLDFTSCQCAPGGVVSKKFCENTCKTSSVIFFLTVLPGSFVAGLGVVPAMLILLRSVPPETRSLSLGLQGMAVSLFGTLPSPILWGLVIDAACLVWDKACNGARGSCSIYHPDRLRVWMHLLYVVIRTVALITDVYVWKHAKNLNIMDEPVSEEKDNIRRNSIKMQAVQPDQ 744
2 -26.000[G] COG2271 Sugar phosphate permease  ali follow..  13  23YRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQGFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFLPAGLILAAAVMLFMGF---------------------------------------------------------------------------------------------------------------------------------------------------------------------VPWATSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGIPPLLFLLGMAWF-----------------NDWHAALYMPAFCAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKAEQELTAKQ---IFMQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEY-AGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIATIVYWMNPAG-----------------------------------------------------------------------------------------NPTVDMICMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVAASAIVGYTVDFF---WDG--------------------GFMVMIGGSILAVI--LLIVVMIGEKRRHEQLLQERNGG............... 452
3 -25.900[G] KOG4686 Predicted sugar transporter  ali follow..  10  53.....MALVFMCLLGFGSYFCYDAPGALQNYFKKDLNLTSAQFTLIYSIYSWPNVVLCFVGGFLIDRLFGIRLGTIYMMILLVGQLIFAC----------------------------------------------------------------------------------------------------------------------------------------------------------------------GGILDAFWMMILGRFIFGIGAESLAVAQNSYAVLWFKGKELNMVFGLQLSVARFGSTVNFWVMQPIYEYV------------------SNFYKGHTALGVVLLLATLTCVMSMTCALILGWMDKRAERILQRNNNPAGQIP---------KLTDVFSFKPPFWMVSIICVAYYVAIFPFIALGQNFFVDRFGLSPAEANTVDSLVYL-IAAVSSPVFGFIIDKLGRNVTWVFTATLTTIGAHALLTFTQLTP-----------------------------------------------------------------------------------------------YVGMIIMGLSYSMLAASLWPLVALIIPEYQLGTAYGFCQSIQNL-GLAVITIVAGIIVDHS--------------------GGEHMWLQLFFMGWLTIALISTGVIWAYNNKNRGNLNMTPQQRAQFVSAENYQNF..... 477
4 -23.100[U] KOG3764 Vesicular amine transporter  ali follow..  11  96.......LTLHQTATQHMVTNASAVPSDCPSEDKDLLNENVQVGLLFASKATVQLITNPFIGLLTNRIGYPIPIFAGFCIMFVSTIMFAFSS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SYAFLLIARSLQGIGSSCSSVAGMGMLASVYDDEERGNVMGIALGGLAMGVLVGPPFGSVLYEFV------------------GKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGT--------------------------PLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILA----KMGRWLCALLGMIIVGVSILCIPF-----------------------------------------------------------------------------------------AKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCM-GYAIGPSAGGAIAKAI--------------------------FPWLMTIIGIIDILFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNIQS 502
5 -21.400[R] KOG2563 Permease of the major facilitator superfamily  ali follow..  10  47.....IVLLAVALLNNTNTMSWIGYAPSGNYVNSFYGESS--AAWLSMVYMMCTIPVGMFAMWAGREWGLRTAVLIAGWANGIGAVIRVI-----------------------------------------------------------------------------------------------------------------------------------------------------------------SSLDFVPQDLRFPICMTGQGIAAIAYPFIMFLPTKVAGSWFPDTQRAIATSIGVMSNPLGVLMANLISPAIVKSPEHVIW------------------LNIFTCVPSLIAMLIATFGVNRSEPKIPPTFSASKPQ----------------MDFVSGMKSCFSSKQYIILLIVMGGGIGMFNCLYTVMLELLC-PSGYSNFFSGVC-AALMIVGGVFGAAASSIFVDRTKLYEETLKIALGAAVIFGLIFLQLTLH-----------------------------------------------------------------------------------------QGYSVILGVTCLLFGVLGLATYPIGLELASECTFPVSEATSTGLIVLSGQIQSVI--VFIMKNFARPL----HIQVCQLTPDDTINTPKDNTMSIMIFSLLATLLVLTLVVLFKPVYKRLEAERGNRATADKAKELSNQNKDRITLQA 497
6 -21.100[R] KOG2325 Predicted transporter/transmembrane protein  ali follow..  11  36.......IITAAVVSCLNAVENSVLGIGEWPYMREIDPNATAQGLATSASKCGHAVFALIFSIWSYKTSSVK-LIASRLIAIAACMIYLTIEYV--------------------------------------------------------------------------------------------------------------------------------------------------------------------KTDKRYVLMAVYTLLGIANSGG-TVLRGYVTLCSSNEDRPRAFAALGLSFIFSIIVGPTIQLIFSAIPYPGYEIIPGIWFHLYSAPIWISFILTILTVFVI----LILIEDISREKKTKLRPSESQSSFSMERWRSLYEKLKKSN---------LDWKLIVVCFFVRMAVSFSHSTLSTIGSILYMVMFGWDGATTVRVGSITMVIFGVMSSTILLLYIFC-HFGKILPQHKVFLFFTIAFGAVYIITY-----------PFEFTSNPVAKYNETTRAGCNPEEY----------------SWCSTALAV-----------------------------NPMLYLSVTILVAGMSIPIMSTALDTVYSRILGNIDQSVAHGAMAVIDDI-LYMITPIFTTTMFTLY------------GIGPLW----------IVKSMAFGIIALTVLVSG.................................. 483
7 -21.000[G] COG2814 Arabinose efflux permease  ali follow..  14  29.......VFAMSVCAFALIASEFLPVSLLTPMARDLQVTEGMTGQGIAISGAFAVLTSLFISALAGSLNRKTLLLGLTLAMGVSGAIVALPNY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------IYMLGRALIGVVVGGFWSMSAATAIRMVPKRDVPRALAIVNGGNALATVVAAPMGAYLSTVI------------------GWRGAFLCLVPVSLIALAWQWKTLPSMPAAARAPGIGQ-----------------------VFKVFTLFKHPGVVVGMLASSLLFMGQFGLFTYVRPFLETVTNVHGATISLFLLVLGA-AGFIGTVLIGRVLQRSFYQTMIVIPVLMALTALALIAFGSSVAI-----------------------------------------------------------------------------------------------VLVLLALWGLTGTSAPVGWWAWIAKVFPKDAEAGGGLFVAVVQM-SIALGSTVGGILFDHS................................................................................ 378
8 -20.700[R] KOG3762 Predicted transporter  ali follow..  21.......AFICRLFYLSFFASFGSLFPLLAVYFKQLGMTAAQAGFLIGSRPIVEFLSGPFWSQFASRFRKQKLL---LLFSLGSLVLFTLGIGLVQPVTPYCIVYVPEGNKTCQTMLAPAGKIIRGGALGMLKETLVGGSTRPARQRRQTQSPLVEKIIDLSSFDSEEDTVAGIAP-------------------------------------------------EYITRDRVCNYNEDNYGILVSPPHSTRVYRQPAVEQAFMLLLILICLCEFFSAPALPLADAATLHSVRDNPAEF------KIRLMA-SVGWGFAMFIMGIALDYSDTFRNHPCPATTEKNYTLCFVMCVIFMLAAMGLASKFKFDDDVPAPGEVHGLVMDAEKARARITQSEGGGGSENSLLLAMKALASMHILLFFVSVVVMGGGAGLVFSFLYWHLQ-----DIGGSPVLFGILSVVNHASEIFYVFKLINKY-----GHVRVMYLCLAVNFFRFMALSIL-----------------------------------------------NP--------------------------------------------MVLPLQILQGACLATVWSCASSYISLVAPPHAKQHAQYALQVGYHGIGKGLGSIIGGSVISI-------------GTRTTF-----------IYGLICLATCAGSFGLNKLFKYEGIKYGAGNFEEEDMDIMAPQGVPMARDG 593
9 -18.800[P] KOG0252 Inorganic phosphate transporter  ali follow..  10  15.AKTQMYHFTAIVIAGMGFFTDAYDLFSISLVKKPGTLPPNVAAAVNGVAFCGTLAGQLFFGWLGDKLGRKKVYGITLMLMVLCSLGSGL-------------------------------------------------------------------------------------------------------------------------------------------------------------------SFGHSANGVMATLCFFRFWLGFGIGGDYPLSATIMSEYANKKTRGAFIAAVFAMQGFGILAGGIVSLIVSSTFAPTYEVDPVGSTVPQADYVWRIVLMFGAIPALLTYYWRMKMPETSKVLQVDLIAEEEAQSNSNSSNPNFTFGLFTREFARRHGLHLLGTTLLDIAYYSSNLFQKDIYTAIGWIPAAETMNAIHEVFTVSKAQTLIALCGTVPGYWFTVAFIDIL---GRFFIQLMGFIFMTIFMFALAIPYDHWRHRENRIG------------------------------------------------------------------------------------FLIMYSLTMFFANFGPNATFVVPAEIFPARLRSTCHGISAASGKAGAIV-GAFGFLYAAQSS---------DSEKT----YPPGIGVRNSLLMLACVNFLGIVFTLLVPESKGKSLEEISREDEEQSGGDTVVEMTVANSGR 538
10 -18.000[P] COG2807 Cyanate permease  ali follow..  14  14.....VLIAGILMIATTLRVTFTGAAPLLDTIRSAYSLTTAQTGLLTTLPLLAFALISPLAAPVARRFGMERSLFAALLLICAGIAIRSLPS---------------------------------------------------------------------------------------------------------------------------------------------------------------------------YLLFGGTAVIGGGIALGNVLLPGLIKRDFPHS-VARLTGAYSLTMGAAAALGSAMVVPLALNG------------------FGWQGALLMLMCFPLLALFLWLPQWRSQQHANLSTSRAL------------------------HTRGIWRSPLAWQVTLFLGINSLVYYVIIGWLPAILISH-GYSEAQAGSLHGLLQLATA-APGLLIPLFLHHVK-DQRGIAAFVALMCAVGAVGLCF---------------------------------------------------------------------------------------------MPAHAITWTLLFGFGSGATMILGLTFIGLRASSAHQAAALSGMAQSVGYLLAAC-GPPLMGKIHDAN---WS........................................................................... 366
11 -17.100[G] KOG2532 Permease of the major facilitator superfamily  ali follow..  11  6........LTLNFTVICMDDIVEDFHMFHNSTETHWFERSTEKSLLFSGVAIGGLIGLVPSVPQISSIGLRNTQTISGFISGLGSFLFPL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------AVSVGFYTSFLCRVLQGIGAAVLFTAVGVVPGVWAPKSEANTFMSILACAFQLSNVICMPVSGLLCESAV-----------------GWRSIYYISGAITFVLYTVFWFTYTDDPKLHRNVSQKELRKISTGKVEKIKEPV---------PYFAVSTDPTVIISWISLFGGNMGFYVLCIYGPTYLREVLKFDVKETGFLTALPFILSAIAKFSAGRISDKLTGLSERARFVFFASIFQIGLVAGLVVMAFTTNRVIAQIAFNFAIVSSGLN----------------IMGVVKFADLPKNLIF-------------------------------------------VNLPICQFAGSFREILYKIETLKVRCLQHVHYTLTVMSFTAYASQFL-SPTLVSIICNYTNEQW-------------------KTFFLVISGLIVACNAGFPFLARSDAAGYTKKQEPTVK................... 451
12 -15.400[P] KOG3574 Acetyl-CoA transporter  ali follow..  13  75.......ILLLLFLYVLQGIPLGLA-GSIPLILQSKNVSYTDQAFFSFVF--APLVDAVYVKNFG---RRKSWLVPTQYILGLFMIYLST---------------------------------------------------------------------------------------------------------------------------------------------------------QVDRLLGNTDDRTPDVIALTVAFFLFEFLAATQDIAVDGWALTMLSRE---------VGYASTCNSVGQTAGYFLGNVLFLALESAD--------------FCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENEVSVVKEETQ---GITDTYKLLFAIIKMPAVLTFCLLILTAKIGFSAADAVTGLKL-VEEGVPKEHLALLAVPMVPLQIILPLIISKYTAGPQPLN-----TFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPI---------------------------------------------------------------------------YYYIVVLLSYALHQVTVYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVA-LWLVDPNCRDAVELCKKLGGSCVTLDG------YYVESIICVFIGFGWWFFLGPKFKKLQDEGSSS..................... 542
13 -15.400[P] COG2223 Nitrate/nitrite transporter  ali follow..  13  31.HRVASRNLWISVPCLLLAFCVWMLFSAVAVPKVGFNFTTDQLFMLTALPSVSGALLRVPYSFMVPLFGGRRWTAFSTGILIVPCVWLGF--------------------------------------------------------------------------------------------------------------------------------------------------------------------AVQDTSTPFSTFIIISLLCGFAGAN-FASSMANISFFFPKQKQGGALGLNGGLGNMGVSVMQLVAPLVVSLSI-----------------GSHGVEQPDGSQLYLANAAWIWVPFLAIFTLAAWFGMNELATSKAS---------------LKEQLPVLKRGHLWIMSLLYLATFGSFIGFSAGFAMLSKTQFPDVQ--ILHYAFFGPFIG-ALARSAGGAISDRLGGTRVTLINFVLMAIFSGLLFLTLPTG---------------------------------------------------------------------------------------GVGGSFIAFYGVFLALFLTAGLGSGSTFQMISVIFRKLTMDRVTAAALGFISAIGAIGGPKAFGSSLALT------------GS------------PVGAMKVFLIFYIACVVITWAVYGRHSKNKK....................... 465
14 -15.100[R] KOG2816 Predicted transporter ADD1 (major facilitator superfamily)  ali follow..  10  9.......LRHLLVTVFLSGLAEYLIRPVMTDVDDSCSLAVYLTGVQQVTVGMGTMVMMPVIGNLSDRYGIKAMLTLPMCLSVLPPAILGY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------RRDTNFFYAFYVIKTL----------FDMAKNVHGTKRISMFGILAGVSSISGVCASLSARFLSIAS----------------------TFQVAAISLFIGLVYMRVFLKERLQDADDDDEADSGGCRSHQEVH--------------NGGDLKMLTEPILRDAPTKTHVFNSKYSSWKDMYFLKARFGFNKNDFAELFLLVTIIGSISQLFILPTLSSTI--GERKVLSTGLLMEFFNATCLSV---------------------------------------------------------------------------------------------AWSPWVPYAMTMLVPGAMFVMPSVCGIASRQVGSSEQGKVQGCISGVRA-FAQVVAPFVYSPLTA------------------LFLSENAPFYFPGFSILCIAISLMIGFLQSLLIKDHPSLPLVNITINNPSKAEA.......... 415
15 -14.700[G] COG0738 Fucose permease  ali follow..  14  19.KNYGFALTSLTLLFFMSGFITCLNDILIPHLKNVFQLNYTQSMLIQFCFFGAYFIVSLPAGQLVKRISYKCGIVVGLIVAAIGCALFIP----------------------------------------------------------------------------------------------------------------------------------------------------------------------AASYRVYALFLGALFVLASGVTILQVAANPYVTILGKPETAASRLTLTQAFNSLGTTVAPVFGAVLIL-------------------AATDATVNAEADAVRFPYLLLALAFTVLAIIFAILKPPDVQEDEPALSDK--------------KEGSAWQYRHLVLGAIGIFVYVGAEVSVGSFLVNFLSDP-GLSETDAAHHVAYF---GAMVGRFIGSAAMRYIDDG-KALAFNAFVAIILLFITVATTGHIA----------------------------------------------------------------------------------------------MWSVLAIGLFNSIMFPTIFSLALHGLGSHTSQGSGIL---CLAIVGGAIVPLIQGALADAI................................................................................ 386
16 -14.000[G] KOG0569 Permease of the major facilitator superfamily  ali follow..  10  6......IHILSIALCLSSGFQQGYIASVLNQPIERTGHPHLLWSLLNVCFPIATIFGQFLAGWMCSQFGRKHTALIASFLYIPGALLCAAAKWCFPA---------------------------------------------------------------------------------------------------------------------------------------------------------------------FELLFVGRIIWSLANGVNTVNATVWIVECAPPQIRGRMAAMQEFFMALGSLLTQAVGVPFST------------------DELWPYNFLPNCAVVVVSMVMFSWVAESIMEKYNDVDRARKALAQYHGVSEDDPSVESEIRICEQSIGRLIRYCAWVGVMVKIAYVFTGARSLRGYSTFILYTLSHFTYSQATWLSFATGLLRL-PFTLVPVFLVDRL--GRRPLIIVSMLVSFVSILVMIIAINI-------------------------------------------------------------------------------------NGELKYATFIGLTVLLLVNTCGIGSVS-RFYAAELVPRNLLLSSVSTLTMLTKIGVEFAFYPTA---------------------------NVIGAQSLLLFLIPTGVFTVMCYLMCPETSRMTVNEVLNNVAAKKKMDVVFPM....... 494
17 -13.400[R] KOG2615 Permease of the major facilitator superfamily  ali follow..  13  13.......LFTVWIIVLCTALPISSLFPFLYFMIDDFNIAKKEAGFVGCSFMLGRAFTSVAWGLVADRYGRKPVILIGTASVVVFNTLFGL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLNFWMAIITRFCLGSFNGLLGPI--AYAMEIFRDEYQGLALSAVSTAWGIGLIIGPAIGGFLAQ-YPSLFSQDSIFGKFP-----FFLPCLAISVFAFLVTIVSSRIPETLHNHKFNDDESYDALKDLSDDPESNKVAER------NGKSSLLNNWPLISSIIVYCVFSLHDMAYTEIFSLWANSPLGYSTADVGSVLAFSGFGLLIFQLSLYSYAERLL--GPIIVTRISGSLAMVVLSCY------------------------------------------PLIAKLSGLAL--------------------------------------------TVTVTSASVAKSVLGTSAITGLFILQNKAVRQDQRGAANGIAMTAMSLFKAI-GPAAAGIIFSWS................................................................................ 413
18 -13.300[R] KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily)  ali follow..  11  104.....LVVFQIMLLTCVTYMGSSIYTPGQEYIQEEFHVGHVVATLNLSLYVLG--------------------YGLGPIIFS----LSETARY------------------------------------------GRLNLYMVTLFFFMIFQVGCATVHNIGG------------------------------------------------------------------------------------------------------LIVMRFISGILCSPSLATGGGTVADIISPEMVPLVLGMWSAGAVAAPVLAPLLGAAMVD--------------AKNWRFIFWLLMWLSAATFILLAFFFPETQHHNILYRRALKLRKETGDDRYYTEQDKLDREVDARTLYRPLKMIIKEPAILAFDLYIAVAYGCFYLFFEAFPIVFVGIYHFSLVEVGL-----AYMGFCVGCVLAYGLIVPRFRNGTFTPEAFLIVAMCVCWCLPLSLFL----------------------------------------TARVHWILPVISEVFFVLAVFNIFQATFAYLATCYPKYVASVFAGNGFCRASFACAFPLFGRAMYDNLAT---------------KNYPVAWGSSLVGFLTLAIIPFIYGPSL................................................................................... 539
19 -12.500[R] KOG0254 Predicted transporter (major facilitator superfamily)  ali follow..  117......................................................................................................................................................................................................................................................................IEWLYVARVFAGLTGGGMFVVLPIFIGEIADNSIRGRLCSFFTLTMNTGIMVGFVVSSHI----------------------AYHVIPCAVVGLPVLYVLLATRYPEPNVSKEEERAYQKHFDEMRLAIQQQNNDTDDNGLSMSDFLTKRSLKALATGLVLMVANIFTGTFAFNNYMSNIFDAVTQLDPNTNTIIIGAVQI----LGTLASIYLVDRY--GRKILLIVSCAGSGIGTSAFGLYAFYAEEQKVDLS---------------------AFSAWLPVT--------------------------------------------------------LMAFIIFIANVGVISVT-MVVLVEILPQKIRAVATSFCLGCLSFFAFASL--TFPLMMFHL---------GLAATMWFC-------------AAVSVICLFYVVVCLEETKGRSMYD........................ 472
20 -11.100[R] COG2270 Permeases of the major facilitator superfamily  ali follow..  108.............................................................................................................................................................................................................................................................APGSPIILPIICMILASIAAEFSIVFN-----SMMPRLTNPQNVGRISNLAWGLGYLGGMVVLIAVVTLLATGLTIAGVKPLFGLDPATGEDARITGPLAALWYLVFILPMF-----------------LLTSDAEKGLPFAAAIRSGLGELKITLRELRYRPVLLRFLIARMLYQDGVNGVIILGGAFAAGMFGWATMEI-GLFGILLNVVAIAGCFAAGRLDQKL--GSRITILISLALLLLATVGIVST------------------------------------------EKGSTLFGWIQLSTADNDRIFATGAEKA---------------------------YLLYGVLIGLAFGPVQASSRSYLARNITVAEAGRYFGIYALSGRATSFM-ATLSFSIATTIS--------------------GSAHIGMATLIVFLGAGFLLL....................................... 449
21 -10.500[S] KOG3098 Uncharacterized conserved protein  ali follow..  1............................MAPTTRRYELLSAA------------------------------MLGFGHLCIMVG--------YDSGFFDQEPTNLSGIENCAKAREMRQGTESASTIYLILYSAFMIIVTNVILGQKMPKSFVLESVIHSIHEKAIGKYAGYYGQAVMYIIYMILNEIGAKYILICSAICFASFPLGFFFVNS--------------------------------------------------YYYYFSQMLLGFGYALYYQGHGGYLTSHSTRKTIESNINIAWCVGCICLLLSSGILATVTHMTLDSREIMQNLKNST---------EFEPVERRFSDLEIKLLFGVFLGASVLGIVNFISCPGKDVTNCIQETKKKGTFMEGFKQTCSALTSKSMLQ-----LFPLFTVLGTSSFWLSIFTTAMNFTAANSNL-TYLAAIYPLSVGVIGTALFITQMSRRFKDFSL-TMLIGAIFSILGFGLVHVSTPYD------------------------------APMRPTQEVPLLFG----------------------------------------HSYLVISVIGVIVGIGDCCLNS-CRSVICALAMPDRRAQAFSI----SKLYQALGSCVLF-----------------------FASPIIPLYVYTIGVSIHLIIANVFFNITARRTQTMEKDMQ....................... 519
22 -10.300[S] KOG3097 Predicted membrane protein  ali follow..  10  46.......ISIISIAFMVQFTAFQGTANLQSSINAKDGLGTVSLSAIYAALVVSCIFLTLIIRKLTVK----------TLVCSMLCYAPYIAFQLFPRF---------------------------------------------------------------------------------------------------------------------------------------------------------------------YTLVPAGILVGMGAAPMWASKATYLTEQAVDAIIVRFFGFFFLAWQSAELWGNLISSLVLSSGAHGGGSSSNTTVSEEDLQFCGANFCTTGS-DEIFEISMIYLSCIVAAVCIIAFFLDPLKRYGEKRKGSNSAAELSGLQLLSATFRQMKKPNLQLLI------ITVFIGMEQ---AFIGADFTQAYVACALGVNKIGFVMICFGVALCSILFGSVMKYIGRTPIIVLGAVVHFTLITVELF------------------------------------WRPNPDNPIIFYAMSGLWG---------------------------------------------------VGDAVWQTQINGLYGLLFRRNKEAAFSN----YRLWESAGFVIAY-----------------------AYATTLCTQMKLYILLAVLTLGCIGYVIVEILYRKKQRKLKKQEKLEAAEKEKEAAAAAAAAAL 509
23 -10.200[W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases  ali follow..  10  4.....PIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRK-------SIDSAASHYQEPIGFRFNAYNRTFHVQLHPISLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGV-------FEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSII----YRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRM-----------KEGNNDPIRTREEIVSLFYNHI---------KAVNEIYEGTNFNGIKG-----------LHFVIQRTSI---------YTPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPAGGICQVHQRYNEGSRGWVYRSLN--TGIVTTLAHEIGHNFGNFIMFASATSGDKPNNGKF-CSVKNISAVLAVVLKSMRNASPVGIGKRNCFQERTSAFCGEECDCGFSQ-DKCCVPHEAR--GPCKAQCSPS----QGYCCNPDTCSLHGKNEEKICRQESEC-----------------------------------SNLQTCDGRN-------AQCPVSP---PKHDGICQDSTKVC--SSGQC................................................................. 631
24 -10.100[G] KOG2533 Permease of the major facilitator superfamily  ali follow..  10  85......IIPCLWILYFLSCCLRFTVLSFTMNTAQGHSLIQTLSGY--SAHYLALGLALFYVGY----------------------IIFEVPSNLM--------------------------------------------------------------------------MAFIEPRIWVSRIQLTIGV---------------------------------------------VGACHAVLGTKHGNAQS---------------YVALRFFLGVAESGLWPGLAYYMSRWYRGKHLGKRIGWYYTAAQIAAAAVSLVSAGFQKM------------DGARGLYGYQWMFLIWGVVAIAQALSIPWWLPAVASKEHRKSLSSFITPADKSLHSRYIAEMNVGKRWWSDLLKSCLDLRVWPFILMYFGIVGVGNGIFNYCTLIIEE---INPSFSGIDISLLNAPIWLADALG--VTVMPLYDRFHKKFSFFTGSCLIIIAGLAVANYA---------------------------------------PRAWSRYGG------------------------------------------------------LLMIGFGLGPTVPICMAWCSASGVASSLALVTGLGNLGSVVTTYALYSGWPGDP-----------------FRKS------NDVCIALIGVSIIACGIEFLLDKTGFGQFNASFNNHDHEVEDEQEMTDIKPA. 559
25 -9.840[W] KOG4004 Matricellular protein Osteonectin/SPARC/BM-40  ali follow..  12  72.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................CQNHHCKHG-----------KVCELDCVCPIGEFEKVCSNDNKTFDSSCHTKCKYIPPCLDSELTEFPLRMRDWLKNVLVTLYERDEDNNLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKNYNMYIFPVHWQFGQLDQPLRAPLIPMEHCT-FFETCDLDNDGCFGIKQKDIDKDLV.................................................... 302
26 -9.720[G] KOG0637 Sucrose transporter and related proteins  ali follow..  34.......IISVASIAAGVQFGWALQLSLLTPYIQLLGIPHKWSSYMWLCGPISGMIVQPIVGYHSDRGRRRPFIAAGVALVAVSVFLIGFAADMGHSFGDKLENKVRTRA------------------------------IIIFLTGFWFLDVANNTLQGPCRAFLADLADAKKTRVANACFSFFMAVGNVLGYAAGSY---TNLHKMFPFTMTKACDIYCANLKTCFFLSITLLLIVTFSSLWYVKDKQWSPPQGDKEEKTSSLFFFGEIFGAVRHMKRPMVMLLIVT---------NWIAWFPFILYDTDWMGREVYG---------GNSDGDERSKKLYDQGVQAGALGLMFNSILLGFVSLGVESIGRKMGGAKRLWGCVNFILAIGLAMTVLVTKSAEHHREIAGPLA---GPSSGIKAGVFSLFTVLGITYSIPALASIFSTNSGAGQGLSLGVLNIAICIIVSFSSGPLDAQFGGGNLPSFVVGAIAAAVSGVLALTV............................................................................................................................................................................................................................................... 494
27 -9.260[O] KOG0828 Predicted E3 ubiquitin ligase  ali follow..  219.........................NDRWKLLNLQIDFSDKAEK-------------KHSIYSKA------YDIQRGRILSISQS-LFALPHYMSFQNDYNEKIFNDVKELVDEFWNFTDYTDVMTMKDVQDAYNNANFKCEYLIFLQL------EPWNQYTRDQIKLIDDELNWPLGRPANLSSLPPINVVSGLLYSPDCGVRLGL----------------------------------HNVKGTRYELKIMSIRKHLLFGIALFAAQIYLMVNKISFYCFSMINLVDGS----LYFVAASVVPELYLPLVISAFSCFILASIF-----------------------------IRYLISIYASQVNEQNVGIINLLRGNTGTYDENRPRPAFIPDEGSIGGSLYGRFFFMLIIFTFLILSSTSWPRQLRMVFEYILI--FILNSYWIPQIFRNAVKGIPSR------RERARSSIGGNRSQNKMPLLWSFVIGTTIIRSLPVVYVFTYSSNVFRHHKDVHSEHGGGTAEHTVDC--------AICVDQHSYMVTPCHTSC...................................................................................................................................................................................... 737

FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24