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Query: [W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVNYGNRVPARVSQLTLAHEIGHNFGSPHDFPAECQPGLPDGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICRQESECSNLQTCDGRNAQCPVSPPKHDGIPCQDSTKVCSSGQCNGSVCAMFGLEDCFLTEGKADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLILHPGSPCNNYKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVHTPSTNPNKPPALNIYQTLTRPGTLIRQHRQRHRAAAGSVPPGPGAQPRSGAASAPSRTTPSARPSAPPLVAPQVAVAVPPGVVGPPIPLIATHPGSSSSTPAVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQTSSDAAGSSGNGGKKKGKLast
1 -224.000[W] KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases  ali  100  1MSSPIRNRLQLVVTLIFCLFFENVNGLNNFIDNFETLNYRATHVANQVTRRKRSIDSAASHYQEPIGFRFNAYNRTFHVQLHPIDDSLFHEDHMSDVDGGYADIKPSHFLYEGYLKDDPNSHVHGSVFDGVFEGHIQTGEGRRYSIDKAAKYFERDDRPTQYHSIIYRDDEINHRKWRVKRDAENLSEQMQGCGFSSRVRREMTDVQNSGESTDFFTNYMTMGGRSKRANTLRDHDGLYFVRTCSLYMQADHKLYEHIRMKEGNNDPIRTREEIVSLFYNHIKAVNEIYEGTNFNGIKGLHFVIQRTSIYTPDSCDRGRAKTDSDNPFCEENVDVSNFLNLNSQRNHSAFCLAYALTFRDFVGGTLGLAWVASPQFNTAGGICQVHQRYNEGSRGWVYRSLNTGIVTLVNYGNRVPARVSQLTLAHEIGHNFGSPHDFPAECQPGLPDGNFIMFASATSGDKPNNGKFSPCSVKNISAVLAVVLKSMPVDPTRNASPVGIGKRNCFQERTSAFCGNQIYEPGEECDCGFSQADCDQMGDKCCVPHEARGNGGPGPCKRKPGAQCSPSQGYCCNPDTCSLHGKNEEKICRQESECSNLQTCDGRNAQCPVSPPKHDGIPCQDSTKVCSSGQCNGSVCAMFGLEDCFLTEGKADELCFLACIKDGKCTSSVHLPEFSANRTNFLQNMRKDKPGLILHPGSPCNNYKGYCDIFRKCRSVDANGPLARLKNLLFNKRTIETLTQWAQDNWWVVGVGGLVFLVIMALFVKCCAVHTPSTNPNKPPALNIYQTLTRPGTLIRQHRQRHRAAAGSVPPGPGAQPRSGAASAPSRTTPSARPSAPPLVAPQVAVAVPPGVVGPPIPLIATHPGSSSSTPAVIVLEPPPPYTAADPGSAMGGPRRGHRKNKRQTSSDAAGSSGNGGKKKGK 922
2 -107.000[O] KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family  ali follow..  15  76NETAEKNLGVLADEDNTLQQNSSSNISYSNAMQKEITLPSRLIYYINQTKARHQQKHNKAVHLAQASFQIEAFGSKFILDLILNNGLLSSDYVEIHYENGKPSKGGEHCYYHGSIRGVKDSKVALSTCNG-LHGMFEDDTFVYMIEPLEL---VHDEKSTGRPHIIQKTLAGQYSKQMKNLTMERGDQW--------------------------PFLSELQWLKRRKRAVNPSRGIFEEMKYLELMIVNDHKTYKKHRSS---------HAHTNNFAKSVVNLVDSIYKEQ-----LNTRVVLVAVETWTEKD----QIDITTNPVQMLHEFSKYRQRIKQHADAVH------LISRVTFHYKRSSLSYFGGVCSRTRG----------------------------VGVNEYGLPMAVAQVLSQSLAQNLGIQWEPSSKPKCDCTESWGGCIMEETG--VSHSRKFSKCSILEYRDFLQRGGGACLFNRPT-------------KLFEPTECGNGYVEAGEECDCGFHVE----CYGLCCK-----------KCSLSNGAHCS--DGPCCNNTSCLFQPRGYECR-DAVNECDITEYCTGDSGQCPPNLHKQDGYACNQNQGRCYNGECKTRD------NQCQYIWGTKAAGSDKFCYEKLNTEGTEKGNCG-KDGDRWIQCSKHDVFCGFLLCGTPCGPSM--MCLDRKCLQIQALNPLDSKGKVCSGHGVCSNEATCICDFTWAGTDCSIRDPVRNLHPPKDEGPKGPSAT................................................................................................................................................... 791
3 -14.300[T] KOG4296 Epithelin/granulin  ali follow..  13  20....................................................................................................................................................................................................................................................................................................................................................................................................................................................RIFFCILYFNIKYFSFHTFIAELDQTIII---VSDKIGV-LSVCPLHSSFSFIFSIKIMRLILLFLAVFLCRVTAHQC-----DAETECSDDETCCKLGDNTWGCCPMPNAVCCDDRSHC--PTGTTCDPQGARCIGADEKHVNQFNEVVCPDKASKCPDGSTCQGSYGCCP----VPNAVCCADMLHCCPNGTCHGQFCSESDVDPIACGVGKTCPAKTTCCNVRGKNGEPKTM-------------------CCPLSNFNFRPSAVRTLAAQPAITVLM............................................................................................................................................................................................................. 335
4 -14.200[R] KOG3511 Sortilin and related receptors  ali follow..  9  93..............................................VAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHV------------PLVIMTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPE---NSGKVVLTAEVSGGSRGGRIFRSSD---------FAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLWVSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALETSDLGKSFKTIGVKIYSFGLGGRFLFASVMADKDTTRRIHVSTMHVDEPGDTGFGTIFTSDDRGIVHLYTTTGGETDFTNVTSLRGVYITSVLSEDNSIQTMIGGRW-KNECSLHIHASYSISQKLNVPMAPLSEPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGG--IIVAIEHSSRPINVIKFS--CWQTYTFTRDPIYFTGLASEPGARSMNIS-----FKDILERNCEEKDYTIEDGCILGYKEQFLRLRKSSCQNGRDYVVTKQPSIC------LCSLEDFLC---------------RPENDSKCDLEFCLYGREEHLTTNGYRKPGDKCQGGVNPVREVKDLKKKCTSNFLSP....................................................................................................................................................................................................................................................................................... 747
5 -13.700[S] COG4412 Uncharacterized protein conserved in bacteria  ali follow..  10  1MSKTKILGLLTAIAITFNATTNLTIKAY-----------------------------ADNSLQEKSKIS-SNSSASADNAI------------------------------AN-----DDKLIQMLKKNG---------------------------------TIPKNATAEETDKILNNYLAKHEGKDSNDPNKLDMKSIQGLKKYSKDALNKGILKKADKKSKRNGPQTSWDGTVTKDKALVILIEFPDLPHNTLTPQDTDMYYKDYTTSHYQDMIFG-LVSLKEYYNQQSGGSY-DIGGTVVG--YKAQHPAAYYGKNQGSDNSPRARDLVKEALTEVAKHIDLKQFDV---LNGDGNLNEPDGIIHSGM--GEEAGGGSISHSSKVYDMDNGTTKPWKIPGTDMSAYPYTIMPEDGAAVFCHEFGHDLGLPYDTQYSGKGEPVGYWSIMSSGSWSGTIPGT......................................................................................................................................................................................................................................................................................................................................................................................................................................................................... 390
6 -13.300[W] KOG4291 Mucin/alpha-tectorin  ali follow..  9  184......................................................................................................................................................................................................................................................FVTFDGTAYTFNGPVNYYGEVKATQLTAVAMRGNTTTTIEVRLRPLHARWRYRLDVLADGRRVYFDRESLKFQHFDGVTVYTPTYLLNQSQVVVQFDAVENEGYMTGRVFLPWKFINKTAGLF-----------GNWSFNKLDDFMLPNGQVAQLNLNDLR---------------SIHTNFGIKWMLTDREVP-----GVGAALFKREFGRMSGYYANATFQPNYVLDPADFLPANRSY--------------------LERAEELCGE-----CMQCDYAMTLNRDLAHFTKNYYDTIVNMQAENAVRVVSCGVLQTPRFG--------RKLSFDFMPGAKVSFECNEGFILIGDQREC-----LSNGLWNIPEYGYT---ECLREVYYTRRVAICPLMLCIVCGVYQKQLKEDPQWQMPMLPRSRASSARN-----------------LRTLNYDDDSDTDASTLKKTKKWDLDENDEDVTSSEGSQNRNSSKLARD---------------ISYINPNVTTGEKPKQLGRRSLHSASGTELDQHGSPVDGDHPDEDDDFDEADVHTGTTHPVGYHQPLSPEEADQLHRQQYSPTFSGLDSRTSGASSINYTPQAATQNRFGGVPVLPSNTQYYSRPPSSVNTVPLRTAPTPLTQDTGLPSPPLATSPTPSVQ 803
7 -13.000[T] KOG3512 Netrin, axonal chemotropic factor  ali follow..  13  403.......................................................................................................................................................................................................................................................................................................................................................................................................................................................GRCKCNGHASECVATVSSGSGTALSDQDDGPSLFGRSTQMSAKLTMTC-------------------------ACKHNTA--GPECECRATDNDANECKMCQCNGH-------ARRCRFNLKLSGRVSGGVCY---NCQHDTTGRYC-----HYCNHRKVCK----RCDCHPVGSTGKTCNHLSGQC---PCKGLTC-----NRCARGYQQTRSHVA--CIKVPTNANMIQAESAGGGGGGGTGDYKDGGGSQVEEMKKKCKASPKKLNLNKFCMEDYA............................................................................................................................................................................................................ 670
8 -11.500[S] KOG4260 Uncharacterized conserved protein  ali follow..  12  12...................................................................................................................................................................................................................................................................................................................................................................................................................................VFIAAASASYSPEKPVPPPCRACTQLVSSFRAGL-ERTKRGHAGGDTAWEEEKLRSYKN-----------------------SEVRLVEIQEKLCSEGEVINKDHCNLANEHEALLEDCLTCCNGKGDGTRKGNGKCKCDPGNECGPEHTQCCGEGGCTGGGPKSCRKCKKEAGCVDINECLEQQNPCRPQQFCVNSFSCLECDRSCDG--CDGDMCR-----KCADGYELKEGKCHDISAEQRSNYVSFTRMLTYFGMCVAT-----------------CVIFQSSTHIAWGCIVGAAVAGYIAVSEYWINSEAGGGH-QPEIDTKQL.............................................................................................................................................................................. 366
9 -10.700[O] COG5549 Predicted Zn-dependent protease  ali follow..  10  39..............................................................................................................................................................................................................................................................LQIHPLPPELVDLGISLENRSLLGDDGTDYFSQVQPSPL--SKFPVTVAVDYPP--GLTPGSAAQKRYYTWQQAIKTAIADWQFFPLTIVENTTEADITIFYREPPLPRIV------PETGLVSFGRARTAQANYEFYWTDTSPPQLRHRMAIAIKPGLA--PLSLQGTARHELGHALGIGHSDHKED---------ALYPAQTA----DVPAISPRDLRTLYRLYQQ........................................................................................................................................................................................................................................................................................................................................................................................................................................................ 249
10 -10.200[Q] KOG3626 Organic anion transporter  ali follow..  10  6...IFLGLFSFVFFLEAIGGSYINSAVQNIERQFQMSSRTSGFMISASDFGY-AHFGSKGNRARWIGAGAILVSITYLMLASPN--FLFPQGHHDINTTEVSAKLKPTAGQLASNSTLKQLLSYQLIRDRMLINLEDDTTPIEEYQPIGRPPKIGQGQSGNSTYTIFNEALVAAENLIANNTSQNTLRSSLSLFIHRRTNTSTKDIQKIRISAAAPFTFCGKLTNSLRAVIKDSKCKEQTSNSYPFLVFFFSLLLLGIGRDDNIKKKSLPAYFGAISSIRVLSFCNKFYYTLNPPNGLTMGFLFIGSIAFPQGKEGDGSAVQLRDVHKEKLKKSVDEDRTITMKLKDFAKSCKKVLSTKIYMGSVLGRVCDVLA----FKGYIVFLPKYLENHFGIPQYLVHMAMFG---------------VFGFGLGVATG----------------GYVTKKLKLNGRRAAMFVM--MSTLNVCLYSGKIFIGC-----ESIVNSIGSNNRQTNYNFTREC-------NSQCSCENAR-------YPVCDQTGFA-----SPCH----AGCREASDPVLDFTSCQCAPGGVVSKKFCENTCETRSLSLGLQGTLPSPILVIDAA-CLVWDKACARGSC................................................................................................................................................................................................................................................................................................... 679
11 -10.100[O] KOG0006 E3 ubiquitin-protein ligase (Parkin protein)  ali follow..  9  2..................................................................................................................................................................................................................................................IVFVRFNSSHGFPVEVDSDTSIFQLKEVVAKRQGVPADQLRVIDWTVQNCDLDQQSIVHIVQRPWRKGQEMNATGGDDPRNAAGGCEREPQSLTRVDLSSSVLPGDSVGLAVILHTDSRKDSVYCKGPCQRVQPGKLRVQCSTCRFFKCGAHPTSDKETPVALHLIATNSRNITCITCTDVRSPVLVFQCNSRHVICLDC-------HLYCVTRLNDRQFVHDPQLGPCVAGCPNSLIKELHHFRILGEEQYNRYQQYGAEECVLQMGGVLC------PRPGCGAGLLPE----------------PDQRKVTCEGGNGLGCGFA---CCKEACSAVFEADERAAEQARWEAASKETIKKTTKPCPRPVEKNGG--CMH---KCPQPQCRLEWC------NCGCEWNRVCMGDH.......................................................................................................................................................................................................................................................................... 433
12 -9.960[T] KOG1480 Netrin transmembrane receptor unc-5  ali follow..  18  189................................................................................................................................................................................................................................................................................................................................................................................................................LKNEEPIDSEQDENIDTRADHNLIIRQA-----LSDSGNYTCMAANIVAKRRSLSATVNGGWSSWTEWSACNVR---------------------------------------CGRGWQKRSRTCT---------------------------NPAPLNGGAFCE---GMSVQKITCTSLVDGSWEVWSEWSVCSPE--CE-RIRECTAPPPRNGGKFCSQESENCTDGLC................................................................................................................................................................................................................................................................................................... 354
13 -9.940[R] COG1913 Predicted Zn-dependent proteases  ali follow..  12  16...................................................................................................................................................................................................................................................................................DVLAFLQNSLSGFYAKYGI-----------EVRLVGGLSLSKFQHAFDFERRQFLARYFLP---VLSYIRKDFNAKAALGVVNVDIYELIFGLAHPGL----------------------------RVAIISLYRLDRKLLKERALKEAMHELGHVFGLEHCPNPKC--------VMHFSNSIIDTDIKSWMYCEKCLRKLEKNLTRS....................................................................................................................................................................................................................................................................................................................................................................................................................................................... 186
14 -9.890[R] COG5141 PHD zinc finger-containing protein  ali follow..  12  112......................................................................................................................................................................................................................................................................................................................................................................................................................EYFKFVAIHPYSKTSFPVSYDL--------DELDT----------MWLTYYNEFQLSSNSEWENVSKEFLEIVLTIIEREW-MPKIEPVRVEDELDGRC------VICNEAECENSNACD----------------------------NCNTSVHQNC---EGQCCLLACCAFCPDRDGAFCTTLDGCAIPEISFHDTASIPKSRWKLVCCICKLRWGTCV--QCSDKNCYAAYHITCARRAGYDSVDMETYCDKHT................................................................................................................................................................................................................................................................... 363
15 -9.820[TW] KOG1226 Integrin beta subunit (N-terminal portion of extracellular region)  ali follow..  9  84.......................................................................................................................................................................................................VSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDY-IYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLR-------IGFGAFVDKPVS-YISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFAIMQAT-------VCDEKIGWRNDASHLLVFTTDAKT--------------------HIALDG-GIVQPNDGQCHVGSDQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQKIRSKVELEVRDLPEELSLSFNATCLNN-LKIGDTVSFSIEAKVRGCPQEKECDCACQAQAEPNSHRCNNGNGTFE--CGVC----RCGPGWLGSQC------ECSEEDYRPSQQDECSPR---EGQPVC-SQRGECLCGQC---VCHS----------SDFGKITGKYCECDDFSCVRYKGEMCSGH--------------GQCSCGD-CLCDSDWTGYYCNC-TTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCE......................................................................................................................................................................... 625
16 -9.330[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  13  58.......................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................EAAPKCNCSQRGHLKKDCPHIIC-------------------SYCGATDDHCPKAIQCS--------------KCDEVGH---YRSQCPHK---WKKVQCT----LCSKERCPSIWRAYILVDDNEKAKPKVLPFHTIYCYN--------------------------------------CGG-KGH--FGDDCKEKRSSRVPNEDGSAFTGS------------------------------------------NLSVELKQEYYRHMNRNSDENEDYQFSESIYDEDPLPRPSHKRHSQNDHSHSGRNKRRASNFHPPPYQKSNVIQPTIRGETLSLNNNISKNSRYQNTKVNVSSISENMYGSRYNPSTYVDNNSISNSSNYRNYNSYQPYRSGTLGKRR 344
17 -9.250[R] KOG3002 Zn finger protein  ali follow..  16  1....................................................................................................................................................................................................................................................................................................................................................................................................................................................................MAPGGSALKEALESNSTGVDYEVKMAKVEANSKPTKSGSGSIGKFHSSNG---YELLECPVCTNLMYPPIHQCPNG----------HTLC-----------SSCKLRVQNTCP----------TCRYELGNIRCLALEKVAESLEVPCRYQNLGCQDYSKLKHEQHCRFRSYSC----YAGSECSVTGDIP....................................................................................................................................................................................................................................................................................... 159
18 -9.250[R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins  ali follow..  15  205....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................SAVYCRYYNANGICGK-----GAACEPTRKTICPKFLNGRC----------KAEDCNLSHELDCRYFLLGKCNNPNCRYVENAPICF-AKYGFCELGTSCKNQHIQCTD---------------YAMFGSCNNPQCS............................................................................................................................................................................................................................................................................................. 329
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li W, Wooley JC, Godzik A. Probing metagenomics by rapid cluster analysis of very large datasets. PLoS ONE. 2008;3(10):e3375. Epub 2008 Oct 10.