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Query: [P] KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes), from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTAASSTTFPKANKRKNQNIGYKLGHRRAPFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREAQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSCLast
1 -124.000[P] KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes)  ali  100  1MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQQQQQQQPPPPAPPAAPQQPLGPSLQPQPPQLQQQQQQQQQQQQQQPPHPLSQLAQLQSQPVHPGLLHSSPTAFRAPPSSNSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAETEGQPLQLFSPSNPPEIVISSREDNHAHQTLLHHPNATHNHQHAGTAASSTTFPKANKRKNQNIGYKLGHRRAPFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREAQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLSAIIEARGVSVAVGTTHTPISDSPIGVSSTSFPTPYTSSSSC 731
2 -23.200[P] KOG4390 Voltage-gated A-type K+ channel KCND  ali follow..  14  185........................................................................................................................................................................................................................................................................................LVFYYVTGFFIAVSVIANVVETVPCGSSPGHIKELPCGERYAVAFFCLDTACVMIFTVEYLLRLAAAPSRYRFVRSVMS-------IIDVVAIL----PYYIGLVMTDN------------DVSGAFVTLRVFRVFRIFKFSRHSQGL------RILG----------YTLKSCASE--LGFLLFSLTMAIIIFATVMFYAEKG-SSASKFTSIPAAFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRAAKSGSANAYMQSKRNGLLSNQLQSSEDEQAFVSKSGSSFETQHHHLLHCLEKTTNHEFVDEQVFE-VATVNRPSSHSPSLSSQQGVTSTCCSRRHKKTFRIPNANVSGSHQGSIQELSTIQIRCVERTPLSNSRSSLNAKMEECVKLNCEQPYVTTAI. 597
3 -21.500[P] KOG3713 Voltage-gated K+ channel KCNB/KCNC  ali follow..  15  182........................................................................................................................................................................................................................................................................................RVVAVLSFLLILVSSVVMCMGTELQVLDAEGNRVEHPTLENVETACIGFTLEYLLRLFSSPNKLHFALSFMN--------------IVDVLAIL----PF----YVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQT----------------LTYALKRSFKE--LGLLLMYLAVGIFVFSALGYTMEQS-HPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSS.............................................................................................................................................................. 436
4 -19.100[P] COG1226 Kef-type K+ transport systems, predicted NAD-binding component  ali follow..  11  1......................................................................................................................................................................................................................................................................................................................................................................................................................................................................LRWPLFIRIGVIILCLILLFGQIIYILEP-----KQFTSVFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQHRYIEGKVAYKGRDHIILNEKTNRLLKDL----QLGAPSKTVVLIDESLTEGPLIENVHFIRGHAADDGTLKR--ANITEAESVMITADQYKSETDADMLSVLTLLS-----VKGLNPLAYCIVEILTDRFVTNAERAGANQI...................................... 226
5 -15.800[PT] KOG0499 Cyclic nucleotide-gated cation channel CNCG4  ali follow..  8  3....................................................................KSLTKVNKVKPIGENNENEQSSRRNEEGSHPSNQSQQTTAQEENKGEEKSLKTKSTPVTSEEPHTNIQDKLSKKNSSGDLTTNPDPQNAAEPTGTVPEQKEMDPGKEGPNSPQNKPPAAPVINEYADAQLHNLVKRMRQRTALYKKKLVEGDLSSPEASPQTAKPTAVPPVKESDDKPTEHYYRLLWFKVKKMPLTEYLKRIKLPNSIDSYTDRLYLLWLLLVTLAYNWNCWFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASII----PF----------------CYLFFGFNPMFRANRMLKYTSFFEFNHHLESI----------------MDKAYIYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDTVQLALAIDVNFSIISKVDLFKRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVGPDGTKVLVTLKTLQEILVHYPDSERILMKKARVLLKQKAKTAEATPPRKDLALLFPPKEETPKLFKTLLGGTGKASLARLLKLK. 695
6 -14.800[PT] KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins  ali follow..  8  2..............................................................................................................AKINTQYSHPSRTHLKVKTSDRDLNRAENGLSRAHSSSEETSSVLQPGIAMETRGLADSGQGSFTGQGIARLSRLIFLLRRWAARHVHHQDQGPDSFPDRFRGAELKEVSSQESNAQANVGSQEPADRGRSAWPLAKCNTNTSNNTEEEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWY-----LLICRACFDELQSEYLMLWLV---YSADVLYVLDVLVRARTGFLEQGLM--VSDTNRLWQHYKTTTQFKLDVLSLV----PT-----------------LAYLKVGTNYPEVRFNRLLKFSRLFEFFDRT-------------ETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFVYPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPP-PVKDEEYLFVVVDFLVGVLIFATIVGNVGSMIEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEKLKAEIAINVHLDTLKKVRIFQDCEASKDDLMEALTEYPEAKKALEEKGRQILMKDNLIDEELARAGADPKDLEEKVEQLGSSLDTLQTRFARLLAEYNATQMKMKQRLSQLESQVKGGGDKPLADGEVPGDATKTEDKQ. 693
7 -14.800[P] KOG0501 K+-channel KCNQ  ali follow..  9  112...........................................................................................................................................................................KIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS----------KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTF-VGPAGEVISDPKLIRMNYLKTWFVIDLLSCL----P----------YDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLV----------------------LVCVFGLAAHWMACIWYSIGDYEKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKDMRADICVHLNRKVFKEHPAFREFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAIDLHVIKRDLQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRF. 717
8 -13.700[P] KOG1418 Tandem pore domain K+ channel  ali follow..  9  2......................................................................................................DVPTFILHSADTESVISDDDSSYYFDGSVEQLTLRNQEYSDDNRMQRRAPIRRKSALDDDQTSQAMKLLEKYIRK--------KYRHSVIFSQDSADIEQSSTPVGHTQSACQFSRNLTPEQRNGFYSTPLGPAPSEYHFPPGSPQFRESTIREEFKQQYRETWGHWFVRVGKFLYKLLGIQYMLLALMILGYIFLTLEYD-------QQQLDLEVEKQVRLSESTLLAENLLKYLKQWNCGQSNENRCLELITKAFIERSIKVERDIRGEGWNLAC-------------KTNLGRVATIIYGLIGILMLFVLKIFGEHSIKWAQKVRYSIRRCVKRCFRRSKLKRASTIESVASDPVKWALFIVFFFMVVCSLIVSFWEK---------DFLTAFYFFFVSLSTIGFGDVIPEH----ACGNGLLEIKICYISVMINGALKMSGDAVNFPRFLNTKIQLTEKFQLYLISALFVLYFVGLALFSMVYAILQERVENQYMWALELIDQEYQENQKQDPDDHLEIPTILPENAAGMEGWTNTIGKMVSQNPVRWRAKNSAYSMENMPDRPISERRFSVLSPGEAPQAPPPVLGTFMLHSLSVKKKLLARSESILNRTGSPWPHAAEMNRP. 621
9 -13.300[P] KOG4404 Tandem pore domain K+ channel TASK3/THIK-1  ali follow..  10  1....................................................................................................................................................................................................................................................................MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIF------------LIFYGLVGCSSTILFFNIAYIMKSCHQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEG---------SYFDSLYFCFVAFSTIGFGDLVSSQNAHRFANFVFILMGVCCIYSLFNVISILI-----KQSLNWILRKMDSGCCPQCQRGL-----------LRSRRNVVMPGSVRNRCNISIETDGVAESDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVGAFAIMNNRLAETSGDR............................................ 408
10 -12.300[Z] KOG4462 WASP-interacting protein VRP1/WIP, contains WH2 domain  ali follow..  6  54VGGGVVGERKSNTPKSFAAPPVPTGAPSLPTSSNNTQQAEERPSMPALGGLFAGGMPKLRHIGKSSASAAPPSAPAPPTPQSELRPPTSAPPRPSIPPPSPASAPPIPSKAPPIPSSLPPPAQPAAPVKSPPSAPSLPSAVPPMPPKVPPPPLSQAPVANTSSRPSSFAPPAGHAPNVTSESPKFPNRGPSIPSASVPPVPPSSYVLQQRPNRVDDHGRFHFKDDSYLPIPHPFLGVPKVYRGGSGTTV.................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................. 302
11 -12.200[PT] KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain  ali follow..  11  12....................................................................................................................................................................................................................KDEGKPLSSEYGYGRKARPSLDRVFKNVKWGFKKPLSFPSHKDPDHKETSSVTRKNIINPQDSFLQNWNKIFLFACVVALA-YIPIVDSARHCLTLDSKLEIAASLLRTLIDAFYIIHIVFQFRTAYIAPSSRVFGRLVDDAKAIALKYLSSYFIIDLLSILPLPQIVVLAVIPSVNQPVSLLTKDYLKFSIIAQYVPRILRMYPLYTEVTRTSGIVTETA----------------WAGAAWNLSLYMLASHVFGALWYLISFTDALKSGVVESHDFWKKFFYCFWWGLRNLSALGQNLQTSKFVGEIIFAISICISGLVLFALLIGNMQKYLEMRVRKRDAEQWMSHRMLPEDLRKRIRRYEQYRWQETRGVEEETLLRNLP-KDLRRDIKRHLCLDLLKKVPLFEIMDEQLLDAVCDRLRPVLYTENSYVIREGDPVGEMLFVMRGRLVSATTNGGRSGFFNAVNLKA................................................ 538
12 -10.800[R] KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor)  ali follow..  6  702.SASTSGSGSGSSSMQPPKRMPAHLKRGSAASSPGVQSKGTENGTNGSNSSSSNSKNVAKKSADQPLSTLANTRERRSEYGQKRNVSGSRLAATPASKRKLSSKDVEQAADAPEVLTHSDNAVDVGIIDDECGGFGAVGVMNGVASPVANNSEMDTEAEVEAEPTATKAITIHCQQPVTTPVAAAATANERLPGVAPHRRGPRRADRREEELVASAPGYRCRPSMRGADAGAAAAAAAAPTHPHPHRPPPP................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................ 951
13 -10.800[P] KOG1341 Na+/K+ transporter  ali follow..  9  188.SREDPRQSASDVPMDSPDTSALSSISPLNVSSSKEESSDTQSSPPNFSSKRQPSDVDPRDIYKSIMMLQKQQEKSNANSTDSFSSETNGPAFIVQERHERRAPHCSLKRHSVLPSSQELNKLAQTKSFQKLLGLRRDEGDHDYFDGAPHKYMVTKKKKISRTQSCNIPTYTASPSPKTSGQVVENHRNLAKSAPSSFVDEEMSFSPQESLNLQFQAHPPKPKRREGDIGHPFTRTMSTNYLSWQPTFGRNSVFIGLTKQQKEELGGVEYRALRLLC---CILMVYYIGFNILAFVTIACTRHHYSEIIRRNGVSPTWWGFFTAMSAFSNLGLSL---------------TADSMVSFDTAPYPLIFMMFFIII-----------------------------NTGFPIMLRFIIWIMFKTSRDLSQFKE---------------SLGFLLDLLFPSGPTWWLFTTLVVLNATDWILFIILDAVVRQVAKGYRALMGLF--SVCTRTAGFNDLSKLHPSIQVSYMLMMYVSVLPLAISIRR-------NVYEEQSLGLYDSGQDDENITHEDDIKETDHDGESEERDTVSTKSKPKKQSPKSFVGAHLRRQLSFDLEGRKIEDVNKPDFNVFAILFEVVSAYGTVPNTNTSLSAQFTVLSKLV-LIRGRNRGLPYTLDRAIMLPSDKLEQIDRLQDMKAKGKLLAKVGEDPMTTYVKKRSHKLKKIATKF. 885
14 -10.700[TZ] KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover  ali follow..  9  140........QSQTQLHSQHRQHSPPPSGGSVGSQRLDMSKKSMSSPAVGSSCGLPQNQGMIESPSMGSMQFQGSSCTIQTPQQQQPLPAPPAPAPSPSAASATPTAASTSKAATGGDVAQDNSITSEPSETTTTTTTTSEDVVTTYKETSQMSTSQQHKPQNGSTASASISASASASALRSNGGNGKANGSATALHQELQQEEADSAPDKSDDASAVQSDDGCPANGDSADNSQALDSIDSPSHRQRGLSLGRIEEGATGGGQLKVESSDVYQIVDALRRNTNLSFDLSCEALRVVLTSLEQLQRTWMLYEDEEDIIQFLEELVEILI--MFINLVQYYQMETRWSIKRLLL---KTFTAACHLDYIIVDILLTSVLP------LEIVEDMKTHFSNLDRFKQLVKMLTIIFYLGVHFASFLLEIVEGNNPEVLVDMV-------IALILAFNQQFSEHTYNVIIEGM----VFTEKLLLLLNREDDPTRLLNTVLRMFIDIFSHPDTAGMNDI----------------------KVLIDIVVRQLDLDAGSTTRPCYL--------------ELCRRILR------------------------------------NTNYQEHQHRKHDLMKIFTRIFCEETECSASDQQLVREI........................................................................... 791
15 -10.300[PET] KOG4440 NMDA selective glutamate-gated ion channel receptor subunit GRIN1  ali follow..  11  501................................................................................................................................................................................................................................................................................................................................................................................................................................MMGELLSGQADMIVAPLTINNERAQYIEFSKPFKLTILVKKQPFQSLWLLVGLSVHVVAVMLYLLDRSEEEEEDALTLSSAMWFSWGVLLNSGIGEGAPRSFSARILGMVWAGFAMIIVASYTANLAAFLVLDRPEERITGINDPRLRNPSDKSSVDIYFRRQVELSTMYRHMEKHNYESAAEAIQAVRDN--KLHAFIWDSAVLEFEASQKCDLVTTGELFFRSMRKDSPWKQNVSLSILKSHENMEDLDKTWVRYQECDSRSNAPATLTFEN......................................... 812
16 -9.830[PT] KOG3676 Ca2+-permeable cation channel OSM-9 and related channels (OTRPC family)  ali follow..  3  428.................................................................................................................................................................................................................................................................................DRFVKRIFYFNFLVYCLYMIIFTMAAYYRPVDGLPPFKMEKIGDYFRVTGEILSVLGGVYFFFRGIQYFLQRRPSMKTLFVDSYSEMLFFLQSLFMLATVVLY------------------SHLKEYVASMVFSLALGWTNMLYYTRGFQQMGIY------------------AVMIEKMILRD----LCRFMFVYIVFLFGFSTAVVRWRGPACRPPDSSYNSLYSTCLELFTIGMGDLYDFKAVFIILLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAFRSGKLLQVGYTPDGKDDYRWCFRVDEV--NWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSSRVSGRHWKALVPLLREASARDRQSAQPEEVYLRQFSGSLKPEDAEVFKSPAASGEK................................. 839
17 -9.510[PET] KOG1054 Glutamate-gated AMPA-type ion channel receptor subunit GluR2 and related subunits  ali follow..  10  477................................................................................................................................................................................................................................................................................................................................................................................................................................MVGELVYGRADVAVAPLTITLVREEVIDFSKPFMISIMIKKDPLAYIWMCIVFAYIGVSVVLFLVSRFSPYESNEFGIFNSLWFSLGAFMQQG-CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIES-AEDLAKQTEIAGSTKEFFRRS-KIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKRNPVNLAVLKLNEQLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSN.................................... 805
18 -9.360[PET] KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits  ali follow..  10  501................................................................................................................................................................................................................................................................................................................................................................................................................................MVRELIDHKADLAVAPLAITYVREKVIDFSKPFMISILYRKNPLSPIWMYILLAYLGVSCVLFVIARFSPYEENNFTLLNSFWFGVGALMQQG-SELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDS-ADDLAKQTKIEYGAVEATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKRDKITIAILQLQEELHMMKEK.............................................................. 797
FFAS is supported by the NIH grant R01-GM087218-01
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Comments and questions to: webmaster
Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Friedberg I. and Godzik A Connecting the Protein Structure Universe by Using Sparse Recurring Fragments. Structure (Camb.) (2005) Aug;13(8):1213-24