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Query: [K] KOG3815 Transcription factor Doublesex, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLPARATEDPRISIPDDGCPFVSKQSIYTEDDYDERSDSSDSRTLNTSSLast
1 -106.000[K] KOG3815 Transcription factor Doublesex  ali  100  1MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAVAAPQPPPASQPSQPQPPRPAAELAAAAALRWTAEPQPGALQAQLAKPDLTEERLGDGKSADNTEVFSDKDTDQRSSPDVAKSKGCFTPESPEIVSVEEGGYAVQKNGGNPESRPDSPKCHAEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSVTGAERTSAEPESLALPSNGHIFEHTLSSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPSPLAGPLQPPFPQPPRYPLMLRNTLARSQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPSNSTSVFRSSPVLPARATEDPRISIPDDGCPFVSKQSIYTEDDYDERSDSSDSRTLNTSS 472
2 -16.300[O] KOG0802 E3 ubiquitin ligase  ali follow..  7  342LHAA----------PDATSEELRAYDDECAICREP-MAKAKRNH---CSWLD-SCPTC-----RKPLFVGRTENEVNPRTVEVSSDEQLARQLERQNNPVHALATGLFPAEVPDSVENDTSRNLGLDPSWLQTWSSQGSDVAGPSTTSRTVGLG----RVQMMMRHLASVGESYAQTALDDAAWSLWPMNPSQASTSSTTVPPGNGGRTGGLHLRTVSNTTNESLTNILAMAETVREVMPHVPDEIIFQVNFKCILDYL..................................................................................................................................................................................................................... 594
3 -15.200[O] KOG4275 Predicted E3 ubiquitin ligase  ali follow..  6  14.......................RRKRACFDCK-----------RYYC--ANCICKRCSVFASRTDLLKLKPKLIFEGCLEKEELVGLVLTHVAQVDRSRGSNASSNSPGRGQANPIDSLKQSCQNFFSNLSDNISDSLASFDSKVTTKPPESRQPEVPTHIFEQPRVSTREIPTYASAVNGGPQHVHVQQQATTTNGGSQSSSSPSTSTQSSNNRDASSSSQAHVAHQEARNEEQEDAQSKSDCECSDEEIMATFSERVSISLKTDTSGRRVNAAAEPSPVDLANVDNGPAGNTAPSPGCSKPGSSSSKADASSQSSFEELGAIGGISDESKANTDTN..................................................................................................................................... 334
4 -15.200[K] KOG4218 Nuclear hormone receptor betaFTZ-F1  ali follow..  11  1MSSNSDTGDLQESLKHGLTPIVSQFKMVCPVCGDHGLLT--KGFKR-CI-QNCRCPYCRF----QKCL--SVGMKLEAVRADRMRGGRNKFGPMYKRDRALKQQKKALIRANGLKLEAMSQVIQAMPSDLTISSAIQNIHSASKGLPLNHAALPPTDYDRSPFVTSPISMTMPPHGS....................................................................................................................................................................................................................................................................................................... 208
5 -14.600[R] KOG1819 FYVE finger-containing proteins  ali follow..  14  536.ANSQTEGEETGVEAQETLPLPAFMGVQCTACRRH--------H---C--RNC-CHKCSIYDRKPVVSSPQSNLSLLTRQDQFSCNLLHQSHHIHHLFNRSLVPHT.............................................................................................................................................................................................................................................................................................................................................................................. 656
6 -14.500[O] KOG3579 Predicted E3 ubiquitin ligase  ali follow..  27  451.GAGNTGGLEPVHPASLPDSSLATSAPCCTLCHEHFV--SVPSHK-FC-F--CSCEKCPLV-EIATILAGDVKVKKERDS........................................................................................................................................................................................................................................................................................................................................................................................................ 560
7 -14.200[O] COG5243 HRD ubiquitin ligase complex, ER membrane component  ali follow..  9  333............TVTVEQLQNSANDDNICIICMGH--------HLS-CNWRSQTCPIC-----RLPVFDEKGNVVQTTFTSNSDITTQTTVTDSTGIATDQQGFANEVDLLPTRTTSPDIRIVPTQNIDTLAMRTRSTSTPSPTWYTFPLHKTGDNSVGSSRSAYEFLITNSDEKENGIPVKLTIENHEVNSLHGDGGEQIAKKIVIPDKFIQH.................................................................................................................................................................................................................................................................. 550
8 -14.100[O] KOG1645 RING-finger-containing E3 ubiquitin ligase  ali follow..  11  78.VRVSQNESEGIENQNRRMSNGNKVTLRDCLV-GPAVAN-TKGI-IVFDTSTSGFSSDEVEGSLRDVRASRVAAVDDEAHKRILFL.................................................................................................................................................................................................................................................................................................................................................................................................. 180
9 -13.600[T] KOG4825 Component of synaptic membrane glycine-, glutamate- and thienylcyclohexylpiperidine-binding glycoprotein (43kDa)  ali follow..  22  775.......................KHCLRCDHCKQ---ISSLTEH-TECDFGKCRCSRCPLCHEKAHLMGPA---RKTHILQKAPALQPGKSSAVAASGPLGSKAGSKIPTPKGGLSKSSSRTYAKR.......................................................................................................................................................................................................................................................................................................................................................... 925
10 -13.500[T] KOG4846 Nuclear receptor  ali follow..  17  123VTSSLSPPDSLSNGHTTQRHHIGKAISFCKVCGDHGVTS--KGFRR-CL-QVCRCQYCRF----KKCL--DSGMSKDSVRQMKF.................................................................................................................................................................................................................................................................................................................................................................................................... 226
11 -13.400[R] COG5236 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  9  214..................NSEGFKGHPMCAFCSGKRFYS-LYIHMRKCHI--CDCTVQTCLDNKFVVFKDELELQAHILQEHGNILK----------------------------------------------------GKPKFFQSELSTFISAPSRVIRERDDYDLPSISSLPGSSSGSRTDVRSASSPEESRLRLAERAKYYLENSKEDFNKFSSYNEDYSKGRLSAEKLLESYKLLFTKPNADVYLLIHNLAETFPKNSSK---------YNNLNAIYEQREQTLARQTSLPSLSSDSSLSMSIGRGHWGGTNDGGSAGAALGVRNIKNLPTLKSPSASYDPFATTVKKNTLRPVQNIKRTTPQSVSYRTSTNTVAFSPTYLESKKGSSSTSLNNSKDKLKSLNLPQLPPPKPKVQIPGLNRPQIADPKQ-KSSTQDTNVHDNLRELNTTSGGNKKKGKQKQLL.... 634
12 -13.300[O] KOG2231 Predicted E3 ubiquitin ligase  ali follow..  9  167............................CDLCQLHG--RSHRGH--LCEY--CNCHFCDLAEHFRAAFRNEIEYKAHVANVHGKSLNKQQAKQTRTLGPRGRSGQTEQGITSVRTRNDEHNDYQNDLPSITQRHVSIDAGNEEQFPTLRGASTAPSVSLVRPPPPSMRNLSGTSGLARTKENFPALGGGNGGGVTGPTSSSIAARAAQSQHPVAAVFKKPTSAAGSGSRSGPPGNGMLLHVSNRSAAVPKKAATPQVDFPALPGKGNKKNLRNLEEDMLPSGSPVPMANISAKHRSLADDYVSVASPSTFQKLQMVQKEEDEAKARQEALKKSAPKLTAAEFPSLGPSASASSSRTTAPKPSSGSPSLNWSKPANEKKQRELENRKAKVAPAPVLPSPTSKPAPKASNNNVQEQQANKKDKKQKDKKSNQENQPKTAKPKERNNNNEQKTNGAPSTPIRAPPGLKPGGPLKP 686
13 -13.300[O] KOG0320 Predicted E3 ubiquitin ligase  ali follow..  17  243.....DVASPPKRVNRDIDESQKEELYKCPICSKREPVSTKCGH--FC--RECKCPIC-----NKKLTARQF................................................................................................................................................................................................................................................................................................................................................................................................................ 314
14 -13.300[K] KOG4216 Steroid hormone nuclear receptor  ali follow..  11  71.AKNFINLREFFSFLLPALRKAQIEIIPCKICGDHGVIT--KGFRR-CP-KNCRCQHCRL----QKCLA--VGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAEPLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIKPEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITWQTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKNDQIVLLKA............................................................................................................................................................................................ 383
15 -13.000[O] KOG4265 Predicted E3 ubiquitin ligase  ali follow..  9  250LQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLI-RHLCLC--TSCNCPIC-----RLFPGPP-ADPGGAEEARSPVPRVLQPRPGPEPGA...................................................................................................................................................................................................................................................................................................................................................................................... 350
16 -12.900[T] KOG3575 FOG: Hormone receptors  ali follow..  14  1MSPLKMHVNMLQSDHALIMSSFPEPSPSCKVCGDRGASA--TVFRR-CM-QNCACRYCRF----QKCF--AVGMHSSAIQRRDL.................................................................................................................................................................................................................................................................................................................................................................................................... 111
17 -12.800[R] COG5048 FOG: Zn-finger  ali follow..  20  543...................KEMPDKTFECL-CRRYNIRSHIQTHRPYCDHPGCACP-C------GKKFNREDALVVHRSRM....................................................................................................................................................................................................................................................................................................................................................................................................... 630
18 -12.600[D] KOG3056 Protein required for S-phase initiation or completion  ali follow..  23  465................LTTYKMPCKAVICQVCKKH--LKVVDAEKRFC--KDCSCKNCAMIREKKILTGRETLSVRGDEET....................................................................................................................................................................................................................................................................................................................................................................................................... 562
19 -12.200[O] KOG1571 Predicted E3 ubiquitin ligase  ali follow..  18  263.KIRERLDTERRERRARSRPHTLSQDQLCVVCSTNPKEIIL-GHVCLC--EDCTCPVC-----RGSIVS---KAA............................................................................................................................................................................................................................................................................................................................................................................................................. 334
20 -12.100[K] KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors  ali follow..  20  26...TMGNDTSPSEGTNLNAPNSLGVSALCAICGDHGASS--KGFRR-CR-RQCQCRYCRL----KKCF--RAGMKKEAVQNER..................................................................................................................................................................................................................................................................................................................................................................................................... 125
21 -11.900[O] KOG0978 E3 ubiquitin ligase involved in syntaxin degradation  ali follow..  18  819LEELGSESVEAAIVRLQEEVKNCKNILKCGVCFDR-VIV---YH--FC--QQCKCPGCGTAFGQNDVR--LVKM.............................................................................................................................................................................................................................................................................................................................................................................................................. 899
22 -11.900[K] KOG4577 Transcription factor LIM3, contains LIM and HOX domains  ali follow..  21  2MQSATVPAEGAVKGLPEMLGVPMQQIPQCAGCNQDKFILKVLDHSSDCQ-RACKCTAC-----QQGIPPTQVVRKAQDFV........................................................................................................................................................................................................................................................................................................................................................................................................ 109
23 -11.800[O] KOG0824 Predicted E3 ubiquitin ligase  ali follow..  18  1MNASTSSPSQQLQQAINSTID------ECAVCYSLPTTIPSCGHK-FC--FICDCPIC-----RGPIDSQIFKKPLQAVD........................................................................................................................................................................................................................................................................................................................................................................................................ 80
24 -11.600[O] KOG0823 Predicted E3 ubiquitin ligase  ali follow..  19  89.NGENKTYLIAKALNMEKTSSVPGGFFDCNIC-EDPILT---GH--FC-W-GCECPVC-----DGEVTDAEVI--NGDDCDGTKPKLEDCGISLPPRPNAKR.................................................................................................................................................................................................................................................................................................................................................................................. 197
25 -11.500[V] COG3183 Predicted restriction endonuclease  ali follow..  17  165.LTSSIVESTPEGKKILCYTTRYERNAQCQGCGHH--LCEEEGSVPINAETDLICANCHRMIHRRKLKELQELLLANKS......................................................................................................................................................................................................................................................................................................................................................................................................... 279
26 -11.500[T] COG5432 RING-finger-containing E3 ubiquitin ligase  ali follow..  17  1MD-HQITTASDFTTTSIPSLYQLDTLLRCHICKD--LKVPV-GHT-FC--SLCNCPLC-------LFEFRESLLRSEFLVSE...................................................................................................................................................................................................................................................................................................................................................................................................... 82
27 -11.500[L] KOG0287 Postreplication repair protein RAD18  ali follow..  17  1MD-HQITTASDFTTTSIPSLYQLDTLLRCHICKD--LKVPV-GHT-FC--SLCNCPLC-------LFEFRESLLRSEFLVSE...................................................................................................................................................................................................................................................................................................................................................................................................... 82
28 -11.400[K] COG5641 GATA Zn-finger-containing transcription factor  ali follow..  11  104.KNQVKNNGQTMDANCNNNVSNDANVPVCKNCLT--STTPL--------WR---CNACGLFLKRPISLKTDVIKSRNRKSNTNHA................................................................................................................................................................................................................................................................................................................................................................................................... 187
29 -11.400[O] KOG4628 Predicted E3 ubiquitin ligase  ali follow..  10  224.................TKNNANNKYDTCVICRSHPY------HTH-CPWNRRVCPIC-----KRKVFTKGEARASRSRQPSLDNVTDTDDDTTPLLQQQQSNGRQVGQVSSASSAGGAAGSSSSVAAAAVAGTTRHGTFRRGHAGRNPFEESQSSDDENALLASTVRPATSSGAHERINPFDRAPNLPAHLAEQLTESRRSVWSRINFASFFRRQPAVISVAAPPYLERVESGTSAMGLPVTGTIAVASPAS........................................................................................................................................................................................................................... 466
30 -11.100[K] KOG4217 Nuclear receptors of the nerve growth factor-induced protein B type  ali follow..  23  265.PTASSLLGESPSLPSPPSRSSSSGEGTCAVCGDHGVRT--KGFKR-CL-KNCRCQYCRF----QKCL--SVGMVKEVVRTDSLKGRRGRLPSKPKSPLQQEPSQPSPPSP......................................................................................................................................................................................................................................................................................................................................................................... 394
31 -10.900[DKL] COG5220 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB3  ali follow..  19  2.................DDEGARKVDEKCPLCQADRYLNPMKYHK-MC--ESCPTPGCNKILRKAKQIEREVDVRKRISRIFNK.................................................................................................................................................................................................................................................................................................................................................................................................... 94
32 -10.900[S] KOG4623 Uncharacterized conserved protein  ali follow..  14  98..GSSSICANSYYSDVLTAQPPAPKNGLCDQCEAQRLKQELKVYRERLQFR--LCSSCELHEKKKMVLSSKFLIIKGASLLKQPHFN................................................................................................................................................................................................................................................................................................................................................................................................. 207
33 -10.800[S] KOG4791 Uncharacterized conserved protein  ali follow..  22  2......................PNQGEDCSTCT--------KGDS--CPFRHCRCFRCRF-KKRSEI..................................................................................................................................................................................................................................................................................................................................................................................................................... 64
34 -10.800[R] KOG4602 Nanos and related proteins  ali follow..  18  209....SPGPPLGQDQGLGAPGANGGLGTLCNFCKHNGESRHVSSHK--CP---CPCGACPLNGGQQSLYSGRNSAGRRVKR........................................................................................................................................................................................................................................................................................................................................................................................................ 308
35 -10.800[R] COG5152 Uncharacterized conserved protein, contains RING and CCCH-type Zn-fingers  ali follow..  20  253...........................VCLICKK--YRSPI-GH--FC--EQCTCIQCG-LFSVDKNFDRLLKNRKSKNDEAVKQ................................................................................................................................................................................................................................................................................................................................................................................................... 322
36 -10.800[R] KOG3002 Zn finger protein  ali follow..  20  1MAPGGSALKEALESNSTGVDYEVKMAKECPVCTNL-IHQCPNGH--LC--SSCTCPTCRYELGNIRCLALEKVAESLE.......................................................................................................................................................................................................................................................................................................................................................................................................... 112
37 -10.700[O] KOG1813 Predicted E3 ubiquitin ligase  ali follow..  24  276...........................ACFICRE--VVTK--KH--FC--EHCKCFVC-----NQPTIKKRMAEERSKAEQGLR.................................................................................................................................................................................................................................................................................................................................................................................................... 344
38 -10.700[O] KOG1100 Predicted E3 ubiquitin ligase  ali follow..  17  260.GDSEEERWKLAGEAQDTKKMCRVGMSMCRSCGKGEASVLL-RHMCLC--SVCTCPIC-----KSPKTASHVNLS............................................................................................................................................................................................................................................................................................................................................................................................................. 334
39 -10.600[R] KOG1311 DHHC-type Zn-finger proteins  ali follow..  10  65LDPAVHPYAIGSEEPTQVDDLRAPLYKNCVTCRSS--------HCSVC--NRCICPNC--VGKRN-LTVFHLVLRGRTTNEQVTGKFTSGYNPFTIGCWGNCKKTLCHSQLPTFKSHVMEFRKQRKEEQARLANRINGPVEEQNAHADDERDETSVLYVPDQKRADGKMVAVVEFNKNNSVLRQQNTTTTTSRSESQNRITESQSQSMSMSSGCDESRITVGGGGGGAEADGSTCNLFEMERGGGRHKKN.............................................................................................................................................................................................................................. 392
40 -10.600[O] KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein  ali follow..  18  258GIPKESQLTHINLSDKNQLPFIPEASRKCILCLM--------GH--FC-W-SCECPLC-----RQHCQPQEILLRQ............................................................................................................................................................................................................................................................................................................................................................................................................ 337
41 -10.400[R] KOG1595 CCCH-type Zn-finger protein  ali follow..  13  241.................PGENARRRDPSCPKCE-HGVFE----HPAQYRTRLCKCARCFFAHRRDE-------LRPVNASTGSAMVSPRSSNQSPEMSVMSPLTLGSSPMNSPMANGVPLSPRNGGLWQNRVNSLTPPPLQLNGSRLKSTLSARDMDMEMELRFRGLDNRRLGDLKPSNLEETFGSYDSASVMQLQSPSRHSQMNHYPSSPVRQPPPHGFESSAAMAAAVMNARSSAFAKRSLSFKPAPVASNVSDWGSPNGKLE-------GMQRDELNKLRRSASFGIHGNNNNSVSRPA.......................................................................................................................................................................... 537
42 -10.400[R] KOG1313 DHHC-type Zn-finger proteins  ali follow..  22  96FKCAGKPTNILYGTHPGVGNGALNNYTFCNYCRTH--------H---CR----TCGMCVLDMDHH--IGNCVGAGNHK.......................................................................................................................................................................................................................................................................................................................................................................................................... 165
43 -10.400[S] KOG4317 Predicted Zn-finger protein  ali follow..  17  1MMPEKTIISSESSNSSPLNPSSTRII--CHVCN--------KQFSQYCP--RCNFRYCSLPCYKSHSVQCTESFMRDNVNDELKQ................................................................................................................................................................................................................................................................................................................................................................................................... 74
44 -10.400[O] KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor  ali follow..  20  2...........................ECKKCKSNEYTNK--GHP-LC--KNCNCHVCNRVLRKNNFIDKETFLRRKLRKIYNLK................................................................................................................................................................................................................................................................................................................................................................................................... 82
45 -10.400[R] COG5063 CCCH-type Zn-finger protein  ali follow..  25  158...........VKSQVQETPKQLYKTELCSKCQ-HG-LGELKVKKSCKNFRTCVCRRCCFKHGDDNDIAVYVKAGTYCNVSST..................................................................................................................................................................................................................................................................................................................................................................................................... 253
46 -10.300[R] KOG0490 Transcription factor, contains HOX domain  ali follow..  26  3..........................VHCAGCERDRFLLNVLDHIK-CK-RECKCAGCA-ISPSDLVRKAR................................................................................................................................................................................................................................................................................................................................................................................................................. 81
47 -10.300[R] KOG4377 Zn-finger protein  ali follow..  20  405...........................HCRKCVAH-----RRLHLR-CDSPGCSCVTC--VLSRAQLAA-----KHRTGFPKQEA................................................................................................................................................................................................................................................................................................................................................................................................... 489
48 -10.300[R] KOG1312 DHHC-type Zn-finger proteins  ali follow..  17  106VSRAEDSKDHKSGSTEEYPYDYLLYYPACSTCRSK--------HCSIC--NRCVCINC--IGKGNYLISNIFSM.............................................................................................................................................................................................................................................................................................................................................................................................................. 190
49 -10.100[OU] COG5082 Arginine methyltransferase-interacting protein, contains RING Zn-finger  ali follow..  30  50...............DDDKDAIKEAAPKCNNCSQ-------RGHKKDCP-RHCQCSKC.............................................................................................................................................................................................................................................................................................................................................................................................................................. 104
50 -10.100[R] KOG2893 Zn finger protein  ali follow..  22  1MG----------------RKKKKQLKPWCWYCRDFDDEKILIQHQKAKHFK---CHIC-----HKKLYTG-LAIHCMQVHKET..................................................................................................................................................................................................................................................................................................................................................................................................... 61
51 -10.000[R] KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger  ali follow..  17  114...............DDPSNFTIHDAVECDGCGL----APLIGFRYKC--VQCSCQKCELAHKHPEHLMLRMPTNNGPGMV....................................................................................................................................................................................................................................................................................................................................................................................................... 177
52 -9.980[R] KOG1314 DHHC-type Zn-finger protein  ali follow..  15  78VGPGFVP-----LGWKPEISQDTMYLQYCKVCRSH--------H---CR----KCNRCVMKMDHH--INNCCGYQNHA.......................................................................................................................................................................................................................................................................................................................................................................................................... 142
53 -9.950[S] KOG4367 Predicted Zn-finger protein  ali follow..  14  172..................EKAPKEATVMCEQCDCHPPRGPLAKHR-YC--VQCKCYQCLEEGKHSEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRNMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTG............................................................................................................................................................................................................................................................................................................... 365
54 -9.950[O] KOG0827 Predicted E3 ubiquitin ligase  ali follow..  19  5...........................NCVICAEH--------HHN-CQWRSKTCPQC-----RNKCTTRNIRVYFNLANLDVSHIDVGSLQE........................................................................................................................................................................................................................................................................................................................................................................................... 77
55 -9.920[S] KOG2660 Locus-specific chromosome binding proteins  ali follow..  11  16............................CSICDNI-----RDATT-IS--EKCTCPVCKLRPDHQDLRAKIFALKRRKVKAPGIVSLPGKRKERSISSLVVSTPMVSAQAGTTRRRTKAPTRKELRNGSLAERTVKKEESSGDELLESTSSPDTLNKFTQNKRQSKKSCKESISNKENKDGDEPWDSKMDWKPLNFLVEVANGTKPLKSSASQGSGSKSEHANVSRNQFQGSKTKTKNKKRKCKREDDKS.............................................................................................................................................................................................................................. 253
56 -9.860[R] KOG4299 PHD Zn-finger protein  ali follow..  11  239.EGRAEDISSNELLPTPEEYPYRYNNDYCSACHGPGNFLCCET----CPFHTC-CNECKHHSLYNELDEQEELESNVKEEGT...................................................................................................................................................................................................................................................................................................................................................................................................... 333
57 -9.730[S] KOG4020 Protein DRE2, required for cell viability  ali follow..  17  274LDPEDLKKPDPASLRAASCGEGKKRKA-CKNCT--GLAEELEKEKS-C---NCRCASCPYL------MPAKVLLSDSNLHD....................................................................................................................................................................................................................................................................................................................................................................................................... 366
58 -9.650[O] KOG0826 Predicted E3 ubiquitin ligase involved in peroxisome organization  ali follow..  15  217.GTLINPEAMPRKQLPKEVQQSLPQRGECPVCLLTPTACSVSGY--FC-WK-CTCPVTHYPISLDDLVRIYET............................................................................................................................................................................................................................................................................................................................................................................................................... 297
59 -9.640[S] KOG3740 Uncharacterized conserved protein  ali follow..  14  261................MSAATVLSREPMCAQCKT---------------WRAIMCENCMTTNQKKALKVEHTALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKLAFRS................................................................................................................................................................................................................................................................................................................................................................ 369
60 -9.620[O] KOG0800 FOG: Predicted E3 ubiquitin ligase  ali follow..  11  90..................KESFTVMDSQCSVCQKHTF------HMD-CLWSHTTCPLC-----RLALIPSRSRQSQDDPVPSLVSPDEEVSSQPESEPVNHRVVSTQPESEPVNHSGVSSQPESQPVVNHRGVSSQPESQPVNHINDGHEQQCDQDVEGFKEMEEDERNNIGTSSACCSCRTVHYCCVSRDNQIMYAYNNAGDHRNNESLAALCLEKTPPETRGKKTFGFLMKDDFVYFAIVDDVFKKSSVLDFLEKL-----RDELKEANKK-SNVQDQIVRRLIASLEFDHTCLPLSSPSIDGAEQSYASN............................................................................................................................................................... 403
61 -9.530[S] KOG2846 Predicted membrane protein  ali follow..  14  258...................DSPKDR---CKACHAHGML--PKEEYEYTTFR---CAFCNVLNPARKKRPVAPRLSLEAPSDTANKRNDSSESESSDDDSDKEPSARRALLQKLPSGGADMDATAETEDLAMETETIETGSAAPSTAEVAASS................................................................................................................................................................................................................................................................................................................................ 387
62 -9.460[TZR] KOG1704 FOG: LIM domain  ali follow..  9  205............................CAQCND-DQKYMQRANKPVCHWHECCCCVC-----SKNLLGVKYSRVGESGGEDEELLDEDRLGSPHRKVTQKSTKVVRIPASPRVAPRHPHVIQQNLTTTMTIQKPSVVIQNQRPKPPQRAPPPPPSENIYETVLPCSSNNSPNFDKKYSHELPTSPNHHNYYSKTPNNLLTGYPEMDGYSTSSSSDSDDEQLYISNIMAAASLSRVPAKSSSRKSKKNEPMMMSGGGVRMAKKKKSSRCTVS........................................................................................................................................................................................................ 489
63 -9.380[R] KOG4323 Polycomb-like PHD Zn-finger protein  ali follow..  14  176...........NATALKRKSRKVDMVTLCSVCQLSNRIVFCDGHQ-LCEW----CMKCQYRRAKQPLETQDLGLSESDKK........................................................................................................................................................................................................................................................................................................................................................................................................ 269
64 -9.350[KD] COG5189 Putative transcriptional repressor regulating G2/M transition  ali follow..  17  589..................VMDHEEQKPKCP-CKTYKNQNGLKYHRLH-PYR---CEVC------GKRYKNLNGLKYHRGHS....................................................................................................................................................................................................................................................................................................................................................................................................... 681
65 -9.300[O] COG5574 RING-finger-containing E3 ubiquitin ligase  ali follow..  16  359...........................ECAICSN--AYKPVRSHV-FC--LHCFCPLC-----RAKEFPREIKEKFEENENDTFTPS................................................................................................................................................................................................................................................................................................................................................................................................. 442
66 -9.300[R] COG5084 Cleavage and polyadenylation specificity factor (CPSF) Clipper subunit and related makorin family Zn-finger proteins  ali follow..  16  259.......................RRIPACRNCRVHGFCE--LGHILQCTYAMCNNPQCSLYHGAVSADVPEQTEAPISKTAGSINPEDSGSEIGSNSLESNL.................................................................................................................................................................................................................................................................................................................................................................................. 372
67 -9.300[DR] KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins  ali follow..  21  543KNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVF-GHLVVC---ECKCPIC-----RGIIKGTRTFLS............................................................................................................................................................................................................................................................................................................................................................................................................. 618
68 -9.200[R] COG5222 Uncharacterized conserved protein, contains RING Zn-finger  ali follow..  13  263....KRENRQIDGDETIWRKGHFKDLPKCPLTGG--KTSKCCNID-FS--KEAVCPNCSLVPDEKEVLKKQEELHGSSKDGNQPETKKMKLMDPTGTAGLNNNTSLPTSVNNGGTPVPPVPLPFGIPPFPMFPMPFMPPTATITNPHQADASPKK............................................................................................................................................................................................................................................................................................................................. 441
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Li Z, Ye Y, Godzik A. Flexible Structural Neighborhood--a database of protein structural similarities and alignments. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D277-80.