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Query: [L] KOG3818 DNA polymerase epsilon, subunit B, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MNNSITDSVEKKPEQVSFEVQPNALRPVAFHVFTRKYDLNINRDSLQELASFVSKKCGSQWRSQCEPLLDEIAKTWKRVHETQPIVTRPLLIPVLANLNVPHEVRVSSLARVQTLETTGSFLNSSNSEIRETIKNEKYFRVLDAFKMPKFKYDSSRKVFVLSKQSPTLMASASACTDMLNRRFNVVYSRILRNESFQTPSFSGSFSQTGTYQLTPIRNLLGRAGNTFLLFGLLTIAPDGTLWLEDLDSQVQLDVSQAEQGFGLFCPGCLVLVNGQFLSSGLFLVFELGHPPIERRDASLKALNNLDILGLNMDAKQLALLRHAEQAYQSQAFVCISEVHLDNHQTFYALEKIFQKYESSEAVPFCIILCGSFMSSAFHNSGSSIQYKEGFNKLAASLEKFPKICEKTKFIFVPGPNDPWTTNGISLMPKHSIPLHFVNRIQRVCKHTIFASNPCRIIFFSQEVLIYRDDISGRFQRNSLKFGKTPQGTSNINSIPLAEQQVHQQRKLVKTVLDQSHLSPFPSRTRPILWDFDYALSVFPLPSCMGLIDSESSAFDVHYGGCPTFNPGALLLGVHYNWQEVFPVKKEIITHKERILast
1 -160.000[L] KOG3818 DNA polymerase epsilon, subunit B  ali  100  1MNNSITDSVEKKPEQVSFEVQPNALRPVAFHVFTRKYDLNINRDSLQELASFVSKKCGSQWRSQCEPLLDEIAKTWKRVHETQPIVTRPLLIPVLANLNVPHEVRVSSLARVQTLETTGSFLNSSNSEIRETIKNEKYFRVLDAFKMPKFKYDSSRKVFVLSKQSPTLMASASACTDMLNRRFNVVYSRILRNESFQTPSFSGSFSQTGTYQLTPIRNLLGRAGNTFLLFGLLTIAPDGTLWLEDLDSQVQLDVSQAEQGFGLFCPGCLVLVNGQFLSSGLFLVFELGHPPIERRDASLKALNNLDILGLNMDAKQLALLRHAEQAYQSQAFVCISEVHLDNHQTFYALEKIFQKYESSEAVPFCIILCGSFMSSAFHNSGSSIQYKEGFNKLAASLEKFPKICEKTKFIFVPGPNDPWTTNGISLMPKHSIPLHFVNRIQRVCKHTIFASNPCRIIFFSQEVLIYRDDISGRFQRNSLKFGKTPQGTSNINSIPLAEQQVHQQRKLVKTVLDQSHLSPFPSRTRPILWDFDYALSVFPLPSCMGLIDSESSAFDVHYGGCPTFNPGALLLGVHYNWQEVFPVKKEIITHKERI 594
2 -75.400[L] KOG1625 DNA polymerase alpha-primase complex, polymerase-associated subunit B  ali follow..  11  14SGFILVEEDEILKRCVTLSLKPSDLSWELYHLNRQLLDQTVKKDDMDGFVLHLQNEQKESIMRVEEAGLRDVDMLLDGVQEDTEEIVTTPTNKSQRLHPDPFDSISRSRDYGYSTGKSVGHVTPFGSRIEKFVVKFNVGNVAAHAENGNNDVENSEDDIIKRVQTSQRCSLKVNGSGPEPGCRFMYDRTEDRFSALEYRIVRHADAFAASGLYEEQVDPAVASQRSIFAVGMICCDGEGHLNSAERTSGQRVPVDLKRLDQFSIFPGQVVGIEGQNPSGHYLTASKLLDSVPLTLTVDVDLPPAKRQILDQEVLVPAEE---SCQKSEVSFIIASGPFTTSDNLLFEPLNELLAYAKRKP--PQLLVLLGPFVDSEHPEIKKDATFNEIFQVLRKLQDYVEFMGSEVRVVLVPSIRDANHDFIFPQPPFDHIPDLEHQFSSEKPYSLKSLQHKMLTGYSQVKVSCCTVDVLKQLSGEEMSKNPSGVPT-------------DRMSRLASHLLRQRSFYPLYPPPESLPYDSPKALQISSIPDILLLPS-DMRYFVKDAAKCVCVNPGRLAKGGTFVELTYKGGPESMHASIISI 620
3 -74.800[L] COG1311 Archaeal DNA polymerase II, small subunit/DNA polymerase delta, subunit B  ali follow..  12  5......................NIDAATVAKKF-LVRGYNIDPKAAELICKS-------------GLFSDELVDKICRIANGGFIIEKSVVEEFLRNLSNLKPATLT-----------------------PRPEERKVEEVKASCIALKVIKDITGKS--------SCQGNVEDFLMYFNSRLEKLSRIIRSRVNTTPI------------------AHAGKVRGNVSVVGMVNRGDKCYIRLEDTTGTITCVATGNAEVARELLGDEVIGVTGLL-KGSSLYANRIVFPDVPINGNG--------------------------EKKRDFYIVFLSDTHFGSKEFLEKEWEMFVRWQNLAEKVKYIVIAGDIVDGIGVYPGQEDAISDIYGQYEFAASHLDEIPKEIKIIVSPGNHDAVRQAE----PQPAFEGEIRSLFP---KNVEHVGNPAYVDIEGVKVLIYHGRSIDDIISKIP------------------RLSYDEPQKVMEELLKRRHLSPIYGGRTPLAPEREDYLVIEDVPDILHCGHIH-TYGTGFYRGVFMVNSSTWQAQTEFQKVNLNPMPGNVAVYRPG. 477
4 -70.900[L] COG5214 DNA polymerase alpha-primase complex, polymerase-associated subunit B  ali follow..  12  22..................NMDEQTM-KWESWCLQRGNTPKLDLDTFKAFAKDMKFQMERQVKATLKQNPERKSIKQIPGMNIDSILGLPVKTTASGDSLMQESKPSTETLNSSDAGRVLEVLNKELKIVTSKPSAPSKLVIVANFDLKAFNYR-------------IMYQKLYDSSEVLDDRIELFSALTCRKYNISD---------------EDLANPSELTQEPVVVVGRIVVESTGRLNSRRLGAGVRVRLKVDDLPSYSIFPGQIVSVKGSNPSGNMFIAKEILPIPPLPFPSSSK--------------QEHATFVANTNNQPISIYIASGPWSLRDDLSFSPLKSMISYVNKNP--VDLVILCGPFLDINHILIRTGNTSATSLEELFKERVTPILSQLTCPCILIPHINDAASDHPAWPQDA------FNRVALGLPSNFKCFPNPCMFSINDVVFGVSTNDILLHTSREELFRLP---------------SHGNLFARLVSHVLHQRHFYPLFPGGSLEKCNLKLGEFLNTMPDILILPSD-LRYFVKNVENVVSLNPGKATKGGTFAKLTIAPLELGDNGSSNHY 559
5 -43.500[L] KOG2732 DNA polymerase delta, regulatory subunit 55  ali follow..  11  44............................................................................................................................................................................QQYSQIYFARLHLMRTLLYSL----------APTWKSHLPVCKVLGL--EKGKECIIVGTLFKHPDDNLILEDESGRVKLAGSALSPAI--YVTGVVVALHGKETNAGEFFVEDVLEAGLPPQIERP------------------------IDLQEDKYVVLLSGLCIGSKSANPLQFQLLVDHQGLAAQIVHVVIAGNSFEFPITFNLASKDQSTLYEPIKELDIMLSQIAAGVSVDIMPGTNDPANFAL----PQQPLNRCLFPGSSPY-NTFRSCTNPHSFDVDNIRFLGTSGQNIDDLGKYS---------------------EAKSKLDFVERTLRWRHLAPTAPNTLGCYPTDRDPFLIETCPHVYFVGNQDKYD-NRLIKGVRLICIPKFCETGIAVAVNL----RNLECHTLSF 449
6 -14.200[S] COG2908 Uncharacterized protein conserved in bacteria  ali follow..  7  3...........................................................................................................................................................................................................................................................................................................................................TLFIADLHLCVEEP-AITAGFLRFLAGEARKADALYILGDLFEAWIGDDDPNPLHRQMAAAIKAVSDS------GVPCYFIHGNRD-----------------FLLGKRFARESGMTLLPEEKVLELYGRRVLIMHGDAFRTKVHKPWRIAVRMRANSKEANSSKSLAIMDVNQNAVVSAMEKHQV------------------------QWLIHGHTHVHELIANQQPAFRVVLGAWHTEGSMVKVT............... 229
7 -11.400[R] COG2129 Predicted phosphoesterases, related to the Icc protein  ali follow..  13  3...........................................................................................................................................................................................................................................................................................................................................VLLLSDIHSS----TQNLEKILK-----AAEYDAVFIAGDLTQFRPKDAKVVDEIIS---------------EQTDSCLAVHGNCDHEAIL------------------GEKYKALKFIHGKS-VEFDGYTVH-------------GVGGSGITPFNTPSEYTEREILEIMDNFVLRDFNILLSHCPPKGFLDRTYSGVHAGCEAIRERFDVILCGHIH-ESHGVVDSPQLIVNPGPVMWG---RFAVIDVEKKVVELRKL.. 206
8 -11.300[S] COG3111 Uncharacterized conserved protein  ali follow..  13  45...................................................................................................................................................................................................................SVTTVESAKSLRDDTWVTLGNIVERSDDLYVFKDASGTINVDIDHKRWNGVTVTPKDTVEIQGEVDKDWEIDVKQI................................................................................................................................................................................................................................................................................................................... 125
9 -10.600[R] COG1768 Predicted phosphohydrolase  ali follow..  10  3...........................................................................................................................................................................................................................................................................................................................................IYGLADLHLALGPWIGYHQKICSEWQAVVHPEDIVLLPGDISWA-----MNLSEAHKDFAFIGDL---------PGTKYMIRGNHDYWSS------------ASTSKILQALPPSLYYLNQGFALLTPHLAVVGVRL---FLTPSTQEQSYTEQDEKIFLRELGRLKRAFAALPKEVTEVIVMTHYPPISSDGTP---PISEFLEADGRVSLCLFGHIHKVQ-FGNIRGIHYILVAA-------DYVNFVPQ........... 243
10 -8.560[N] COG5555 Cytolysin, a secreted calcineurin-like phosphatase  ali follow..  5  14...................................................................................................................................................................................................................................................RADVARAEIPPMMNHRWPKLLSRRGFLMQAAGLAAAGAFSRPALGQTGQRIQPIDATFLFIADVH-ASGLGPNCQQEGKTDAALLRNVAALNAINDKHWPAEINGVATGLRSAGTRIGMPLGLVVGGDITDDGGGQITQPSEGTQLLQFSQRYSQGVGADRVHMPVYVGLGNHDLDQRRELRDYVEVNHRPGVFFKPPVPATSYDVDTDCYSWDWGGLHLVQTHRFLKQDLATYA-ERWDPAKRTYDDDGAGAPHWWGEADRQALLAALKGYNV------------------------VGIFHGHQHDTPLIYRRDGLDLFKPKAAYMGG---FAVARVTSDGMDVALGEA 382
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Damiano JS, Stehlik C, Pio F, Godzik A., Reed JC. CLAN, a novel human CED-4-like gene. Genomics. 2001 Jul;75(1-3):77-83.