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Query: [T] KOG3886 GTP-binding protein, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVVSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMRLast
1 -102.000[T] KOG3886 GTP-binding protein  ali  100  1MEESDSEKTTEKENLGPRMDPPLGEPEGSLGWVLPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATILDRIHSLQINSSLSTYSLVDSVGNTKTFDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRDAHRFEKISNIIKQFKLSCSKLAASFQSMEVRNSNFAAFIDIFTSNTYVMVVVSDPSIPSAATLINIRNARKHFEKLERVDGPKQCLLMR 374
2 -67.200[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali follow..  19  58...................................STEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTN----------------------------KICREDVSNSSFVNFQIWDFPGQIDFFDPTFDY--EMIFRGTGALIFVIDSQDDY-MEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDM--QTYELCCDMIDVVIDISCIYDKESTAIIKLNNTTVLYLKEVTKFALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKVVK.... 376
3 -36.700[R] KOG1673 Ras GTPases  ali follow..  12  62IVHKISSTAGDIFDGDDDTTTEPTVSGRRFGSSSDSDLVSLKISLLGDCQTGKTTFVVKYVGDENQSFL----EMTGLNLMDKTFYVQ-------------------------GVTISFSIWDVGGDEK-----SKDHIPIACKDAVAILFMFDLTSRSTLNSVFGW---YSQARKWNKTAIPILIGTKFDDFVRLPPNLQWTIVTQARAYAKVMNASLFFSSATHNINVNKIFKFILARLFNLPWKIDRNLTLGEPIIDYDS............................................................................................................... 288
4 -36.500[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  18  2.....................ASRGATRPNGPNTGNKICQFKLVLLGESAVGKSSLVLRFVKGQFHEF---QESTIGAAFLTQTVCLD-------------------------DTTVKFEIWDTAGQERYH-----SLAPMYYRGAQAAIVVYDITNEESFARAKNWVKELQR--QASPNIVIALSGNKADLANKRA-----VDFQEAQSYADDNSLLFMETSAKTSMNVNEIFMAIAKKLPKNEPQ............................................................................................................................... 187
5 -36.000[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  16  2................................STKSYDYLIKLLLIGDSGVGKSCLLLRFSEDSFTPS---FITTIGIDFKIRTIELD-------------------------GKRIKLQIWDTAGQERFR-----TITTAYYRGAMGILLLYDVTDKKSFDNVRTWFSNVEQHA--SENVYKILIGNKCDCEDQRQ-----VSFEQGQALADELGVKFLEASAKTNVNVDEAFFTLAREIKKQKIDAENEFSNQANNVDLGN............................................................................................................... 192
6 -35.900[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  14  1..................MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPA---FVSTVGIDFKVKTIYRN-------------------------DKRIKLQIWDTAGQERYR-----TITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYS--WDNAQVLLVGNKCDMEDERV-----VSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSE............................................................................................................................... 189
7 -35.900[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  20  2.............................SAPAANGEVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKK---YIATIGVEVHPLSFYTN-------------------------FGEIKFDVWDTAGQEKFG-----GLRDGYYINAQCAIIMFDVTSRITYKNVPNW---HRDLVRVCENIPIVLCGNKVDVKERK-------VKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLAGNPQL............................................................................................................................... 176
8 -35.900[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  16  1................................MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDSYLDS---YISTIGVDFKIRTVEQD-------------------------GKTIKLQIWDTAGQERFR-----TITSSYYRGAHGIIVTYDVTDLESFNNVKQWLNEIDRYA--SENVNKLLVGNKCDLTSQKV-----VSTETAKAFADELGIPFLETSAKNATNVEEAFMAMTAAIKTRMAS............................................................................................................................... 175
9 -35.900[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  20  1................................MDEDVLTTLKILIIGESGVGKSSLLLRFTDDTFDPE---LAATIGVDFKVKTISVD-------------------------GNKAKLAIWDTAGQERFR-----TLTPSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRN-DIVNMLVGNKIDKENRE------VDRNEGLKFARKHSMLFIEASAKTCDGVQCAFEELVEKIIQTPGLWES............................................................................................................................ 178
10 -35.600[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  16  2...............................AGTRDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSEN---YITTIGVDFKIRTMDIN-------------------------GQRVKLQIWDTAGQERFR-----TITSTYYRGTHGVVVVYDVTNGESFGNVKRW---LQEIENNCDSVQKVLVGNKCEENERRV-----VLESDARNYAQSMNISFFETSAKEDKNVEPMFTCITSLVLTAKLA............................................................................................................................... 176
11 -35.500[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  18  2................................SMEDYDFLFKIVLIGNAGVGKTCLVRRFTQGLFPPGQ---GATIGVGFMIKTVEIN-------------------------GEKVKLQIWDTAGQERFR-----SITQSYYRSANALILTYDITCEESFRCLPEWLREIEQYA--SNKVITVLVGNKIDLAERRE-----VSQQRAEEFSEAQDMYYLETSAKESDNVEKLFLDLACRLISEARQ............................................................................................................................... 176
12 -35.400[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  20  1................................MAETYDFLFKFLVIGSAGTGKSCLLHQFIENKFKQDS---NHTIGVEFGSRVVNVG-------------------------GKTVKLQIWDTAGQERFR-----SVTRSYYRGAAGALLVYDITSRETYNSLAAWLTDARTLA--SPNIVVILCGNKKDLDPERE-----VTFLEASRFAQENELMFLETSALTGENVEEAFLKCARTILNKIDS............................................................................................................................... 175
13 -35.300[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  17  1.............................MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADC---PHTIGVEFGTRIIEVS-------------------------GQKIKLQIWDTAGQERFR-----AVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLT--NPNTVIILIGNKADLEAQRD-----VTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQD............................................................................................................................... 178
14 -35.300[R] KOG0394 Ras-related GTPase  ali follow..  17  1................................MPSRRRTLLKVIILGDSGVGKTSLMNQYVNKKFSNQ---YKATIGADFLTKEVQFE-------------------------DRLFTLQIWDTAGQERFQ-----SLGVAFYRGADCCVLVYDVNSMKSFENLNNWREEFLIQASPSENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCAS--KGNIPYFETSAKVGTNVEEAFQCIAKDALKSGEE............................................................................................................................... 182
15 -35.200[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  19  2.............................LETNVDQKSFKFKIVLLGEGCVGKSSLVLRFVENKFSCK---HLSTIQASFQNKTVNVE-------------------------DCQADLHIWDTAGQEKYH-----ALGPIYYRGSNGVLLVFDITDRKSFEKVKNWVLEIKTCL--GNTAEILIVGNKIDLEEERQ-----VTRQDAEAYAESEGALYMETSAQDNVGISDAFESLTAKMIEHSRT............................................................................................................................... 179
16 -34.800[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  20  2................................ASVSPLAKYKLVFLGDQSVGKTSIITRFMYDKFDTT---YQATIGIDFLSKTMYLE-------------------------DRTVRLQLWDTAGQERFR-----SLIPSYIRDSSVAVVVYDVANRLSFLNTSKWIEEVRN--ERAGDVIIVLVGNKTDLVEKRQ-----VSIEEGDSKGREYGVMFIETSAKAGFNIKPLFRKIAAALPGMESY............................................................................................................................... 176
17 -34.800[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  15  2...............................CQEDEYDYLFKTVLIGDSGVGKSNLLMRFTRNEFNIES---KSTIGVEFATRNIVLD-------------------------NKKIKAQIWDTAGQERYR-----AITSAYYRGAVGALIVYDITKQSSFDNVGRWLKELREHA--DSNIVIMLVGNKTDLLHLRA-----VSTEEAQAFAAENNLSFIETSAMDASNVEEAFQTVLTEIFRIVSN............................................................................................................................... 177
18 -34.700[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  16  2...................................SYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPV---HDLTIGVEFGARMVTID-------------------------GKQIKLQIWDTAGQESFR-----SITRSYYRGAAGALLVYDITRRDTFNHLTSWLEDARQHS--NSNMVIMLIGNKSDLEARRE-----VKREEGEAFAREHGLVFMETSAKTAANVEEAFIDTAKEIYRKIQE............................................................................................................................... 173
19 -34.600[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  16  2................................SDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSK---FITTVGIDFREKRVVYR---------------ASGPDGATGRGQRIHLQLWDTAGQERFR-----SLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAY-CENPDIVLCGNKSDLEDQRV-----VKEEEAIALAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRMER............................................................................................................................... 187
20 -34.500[T] KOG4252 GTP-binding protein  ali follow..  18  2................................LEEDMEVAIKMVVVGNGAVGKSSMIQRYCKGIFTKD---YKKTIGVDFLERQIQVN-------------------------DEDVRLMLWDTAGQEEFD-----AITKAYYRGAQACVLVFSTTDRGSFEAVSSW---REKVVAEVGDIPTVLVQNKIDLLDDSC-----IKNEEAEALAKRLRLRFYRTSVKEDLNVNEVFKYLAEKYLQKLKQ............................................................................................................................... 175
21 -34.100[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  16  2................................VEPIFEYQFRLILIGDSTVGKSSLLKFFTDGKFAELS---DPTVGVDFFARLI------------------------EMKDGTQIKLQLWDTAGQERFR-----SITKSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPH-RPVFALVGCKLDLINAGGHREV--TTEEAQKFAKQHGLHFVETSARSGANVEEAFRMVTQEVYARIRS............................................................................................................................... 181
22 -32.000[R] KOG0395 Ras-related GTPase  ali follow..  14  2......................MKTLSSGNCTLSVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQ---YTPTIE---------------------------DFHRKVYNIRGDYQLDILDTSGNHPFP-----AMRRLSILTGDVFILVFSLDNRESFDEVKRLQKQILEVKKEAAELPMVICGNKNDHGELCRQ----VPTTEAELLVSGDENCAYFEVSAKKNNVDEMFYVLFSMAKLPHEM............................................................................................................................... 196
23 -30.900[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  16  454.........................SSSKAPEEEDEFDIMGKVIMLGDSGVGKTSLLIRFRDGRYVPS--YFLSTVGIDFRNKVVVVD-------------------------GTRVKLQIWDTAGQERFR-----SVTHAYYRDAHALLLLYDVTNKTTYDNIRAWLGEIRE--YAQEDVVIVLIGNKADCSGSERQ----VKREDGERLGREHNVPFMETSAKTGLNVELSFTAVARQLKSR.................................................................................................................................. 634
24 -30.300[R] COG2229 Predicted GTPase  ali follow..  15  3.......................................ENKIIFTGPVGVGKTTAIAAISDALVQTDASASDMTLDRKRNT--------------------TVAMDYGAISLDEDTKVHLYGTPGQERF-----NFMWEILSQGSMGLVLLLDNARTNPLKDLEFF---LHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAK-----HNLNVPVFEIDARKEDDVKQLVSAMLFSIDPGLE................................................................................................................................ 177
25 -29.900[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  14  14....................................KKEQYSILILGLDNAGKTTFLETLKKEYSLA--------------------------FKALEKIQPTVGQNVATIPVDSKQILKFWDVGGQESLRSMW-----SEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIE-GVPILMLANKQDRQDRMEVQDIKEVFNKIAEHISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK......................................................................................................................... 198
26 -29.500[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  17  18.....................................KEEMELTLVGLQFSGKTTFVNVIASGQFAEDMI---PTVGFNMRKITR-----------------------------GNVTIKVWDIGGQPRFRSMW-----ERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQLA-GIPVLVLGNKRDLPGALDETGLIERMN--LSSIQDREICCYSISCKEKDNIDITLQWLIQHSKSQSR................................................................................................................................ 186
27 -29.000[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  20  14.....................................ERELRLLMLGLDNAGKTTILKKFNGE----DIDTISPTLGFNIKTLEH-----------------------------RGFKLNIWDVGGQKSLRSYW-----RNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLA-GATLLIFANKQDLPGALSSNAIREALE--LDSIRSHHWCIQGCSAVTGENLLPGIDWLLDDISSRIFTAD............................................................................................................................. 184
28 -28.800[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  20  15.....................................DQEVRILLLGLDNAGKTTLLKQLASE----DISHITPTQGFNIKSVQS-----------------------------QGFKLNVWDIGGQRKIRPYW-----KNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLS-CVPVLIFANKQDLLTAAPASEIAEGLN--LHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK................................................................................................................................ 182
29 -28.700[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  19  15.....................................KKEMRILMVGLDAAGKTTILYKLKLG----EIVTTIPTIGFNVETVEY-----------------------------KNISFTVWDVGGQDKIRPLW-----RHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELR-DAVLLVFANKQDLPNAMNAAEITDKLG--LHSLRQRHWYIQSTCATSGEGLYEGLDWLSNNIASK.................................................................................................................................. 180
30 -28.700[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  18  19.....................................NKEMRILMLGLDAAGKTTILYKLKLN----QSVVTIPTVGFNVETVTY-----------------------------KNIKFNVWDVGGQDKIRPLW-----RHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMR-DCLLLVLANKQDLPGALSPAQITDVLQ--LDKLKDRLWNVQPTCALTGDGLLEGLAWLSQNAKLK.................................................................................................................................. 184
31 -28.600[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  18  15.....................................SREMRILILGLDGAGKTTILYRLQVG----EVVTTIPTIGFNVEQVTY-----------------------------KNLKFQVWDLGGQTSIRPYW-----RCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELA-GAILVVLANKQDMDGCMTVAEVHHALG--LENLKNRTFQIFKTSATKGEGLDQAMDWLSNTLQSR.................................................................................................................................. 180
32 -28.300[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  18  15....................................SNKELRILILGLDGAGKTTILYRLQIG----EVVTTKPTIGFNVETLSY-----------------------------KNLKLNVWDLGGQTSIRPYW-----RCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQ-DAALLVFANKQDQPGALSASEVSKELN--LVELKDRSWSIVASSAIKGEGITEGLDWLIDVIKEE.................................................................................................................................. 181
33 -28.200[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  13  18.....................................QKEAKILFLGLDNAGKTTLLHMLKDE----RLVQHQPTQHPTSEELSI-----------------------------GKIKFKAFDLGGHQIARRVW-----KDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALA-TVPFLILGNKIDIPYAASEDELRYHLKVTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYI..................................................................................................................................... 192
34 -27.300[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  12  51...................................RRTKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAV---TSMEPNEGTFVLH--------------------NENNTKKGKVKPVHLIDVPGHSRLISKL-----EEYLPRAAAVVFVVDALEPNIRAASEYLYDILTNASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVHNKVTVAEASGLTGETDQVQEFIREHVKP................................................................................................................................... 260
35 -24.000[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  14  5.........................................KCVVVGDGAVGKTCLLLSYTTNAFPGE---YILTV----------------------------TYSTNVMVDGRPINLSLWDTAGQDDY-----DQFRHLSFPQTDVFLVCFALNNPASFENVR--AKWYPEVSHHCPNTPIILVGTKADLREDRDTIERLRESRLQPVSHTQGYVMYLECSALTQIGLKQVFDEAIRTGLTPPQTPQT............................................................................................................................ 185
36 -20.800[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  10  7................................DSSGSPKPIRIVVVGEKGSGKSSLIMAAARNTFHPNIPSLLPYTNLPSEFFP------------------------------DRIPATVIDTSSRPED-----KGKVVKEVRQADAIVLTFAFDRPETLDRLSKY---LPLFRQLEVRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQYRE-VETSIQWSAQRLDQAKDVLYYAQKAVIDPVGPVIAALKRIFLLSDHNMDGILSDEELNELQKKCFDTPLVPCEIKQMKNVMQV............................................................................ 246
37 -20.400[R] COG3596 Predicted GTPase  ali follow..  15  40.........................................VIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTRDPLRFRLQI-----------------------------GEHFMTIVDLPGESGVRDTEYAALYREQLPRLDLILWLIKADDRALATD----EHFYRQVIGEAYRHKMLFVISQSDKAESTEQKQNISRKICLLHELFQPVHPVCAVSVRLQWGLRVMAERMIKCL..................................................................................................................................... 216
38 -19.300[R] COG1084 Predicted GTPase  ali follow..  13  164.........................................TVVIAGFPNVGKSTLLRTLTGA--PEVADYPFTTKGIQIGHLER-----------------------------KWKRIQVIDTPGPVEDMNNIELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLGIRSVFDI--PVVTVFNKMDLAENVKYLEEYINMVEDP----------LKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV.......................................................................................................................... 336
39 -16.800[R] KOG2486 Predicted GTPase  ali follow..  13  122..........................KSSVKTEDCPADGLPEFALVGRSNVGKSSLLNSLVRRKRLALTSK-GKTQCINHFRIN---------------------------------KWYLVDLPG-NKFTKDYFLNR-----STLVSVFLLVDASIPVKPIDLE-YASWLG-----QNQVPMTLIFTKCDKRKKKKNEANIKEFQDLIQGFFETTPPWIMTSSVTNQGRDEILLHMAQLR..................................................................................................................................... 312
40 -16.800[S] KOG4273 Uncharacterized conserved protein  ali follow..  17  2.....................................ESRPGVLVVGSSGVGKRTLLSRLLSVEFEDSS---ESSSQTEVHGWTINTKYYT-------------------------ADVSVCISHICDEYS-----LPNLPNSHPLVALVMVFDLSELSTLVALQDW---VSHTDINSFDILL-CIGNKVDRVPHEYRRRLLKASDPSRDLYSDIDDFGISETEGSSLGSEDASLDIRGACLE................................................................................................................................... 176
41 -16.600[E] COG4917 Ethanolamine utilization protein  ali follow..  16  1.......................................MKRIAFVGSVGAGKTTLFNALQGN-----------------------------------------YTLARKTQAVEFNDKGDIDTPGE--FNHPRWYHALITTLQDVDMLIYVHGANDPE--------SRLPAGLLDIGVSKRQIAVISKTDMPDADVAATRKLLLETGFEE-------PMFELNSHDPQSVQQLVDYLASLTKQEEAGEK............................................................................................................................ 154
42 -16.000[R] COG0218 Predicted GTPase  ali follow..  15  22....................................QDELPEIALAGRSNVGKSSFINTMLNRKNLARTSG-GKTQLLNFFNID---------------------------------KMRFVDVPGYGCMIEEYLTTR-----ENLRAVVSLVDLRHDPSADDVQMYEFL------KYYEIPVIIVATKADKIPRGKWNKHESAIKKKLNFDPSDDFILF--SSVSKAGMDEAWDAILEKL..................................................................................................................................... 195
43 -15.900[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  11  171..........................................VLICGYPNVGKSSFMNKV-TRADVDVQPYAFTTKSLFVGHTDY-----------------------------KYLRYQVIDTPGRPFEDRNIIEMCSITALAHLRAVLFFLDI-SGSCGYTIAQQAALFHSIKSLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAMKTAMGLKMSTLTDEGVMSVKNAACERLLDQRVEAKMKSKKINDHLN.................................................................................................................. 368
44 -14.600[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  16  57....EGLRKIYKQKLLPLEEFHKFHDFHSPALDDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTT----DRFIAVMHGDEEGSIPGNALVVDAKKQFRALSGFGN-SVTIVDTPGQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGNED-----KIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVRVYLGSFWDHPLHRLFQDEQHDLFQDLQALPR............................................................................................................................ 321
45 -14.400[R] COG1159 GTPase  ali follow..  14  11..........................................IAIVGRPNVGKSTLLNKLLGQKISITSRKAQTT-----------------------------RHRIVGIHTEGPYQAIYVDTPGEKRAINRLMNKAASSSIGDVELVIFVVEGTRWTPDDE-----MVLNKLRDGK--APVILAVNKVDNVQEKVDLLPHLQFLASQMNFLDIVPI----SAETGMNVDTIAGIVRKHL..................................................................................................................................... 173
46 -14.200[T] KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily  ali follow..  14  12............SDEVKESKRINAEIEKQLRRDKRDARRELKLLLLGTGESGKSTFIKQM-AGYSEEDKRGFTKLV-LTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDL-ENIIFRMVDVGGQRSERRKWIH-----CFENVTSIMFLVSDNENRMEESKALFRTIITY--PWFQNSSVILFLNKKDLLEDKAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQL.................................................................................................................................. 351
47 -14.000[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  12  1MAGGEAGVTLGQPHLSRQDLTTLDVTKTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISVRFKNELERNITIKLGYANAKIYQLDDPSCPRPECYRSCGSSMPDEFPT-NFRLVRHVSFVDCPGHDILMATMLNGA-----AVMDAALLLIAGNESCPQPQTSEHLAAIEIM-------HILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKI..................................................................................................................................... 243
48 -14.000[DT] KOG0082 G-protein alpha subunit (small G protein superfamily)  ali follow..  18  6............SSESKESAKRSKELEKKLQEDAERDARTVKLLLLGAGESGKSTIVKQM-NGYSEQECMEFKAVI-LNDLDRITASGYVPNEQDVLHSRVKTTGIIETQFSF-KDLHFRMFDVGGQRSERKKWIH-----CFEGVTCIIFCADEEVNRMHESLHLFNSICNH-----STTSIVLFLNKKDIFQEKDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDQNVKFVFDAVTDIIIKE.................................................................................................................................. 346
49 -14.000[T] KOG0099 G protein subunit Galphas, small G protein superfamily  ali follow..  13  6.....NSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM-NGFNGEGGEEDPQAA-LDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQV-DKVNFHMFDVGGQRDERRKWIQ-----CFNDVTAIIFVVDNQTNRLQEALNLFKSIWNN-----RTISVILFLNKQDLLAEKVLAGKSK-LRISTASGDGRHYCYPHFTCAVDENIRRVFNDCRDIIQRM.................................................................................................................................. 386
50 -13.200[F] COG1618 Predicted nucleotide kinase  ali follow..  11  2...............................RIEGKEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIGGIRTAEIRKEGHREGFSIRDLATGKTGILSHVKGSGPVRNALACDLVVIDEIGPMELISQSFVSAVEEVLESDKPVLAVLHHSSRHPLAQRFRKGFEVLTVDKGNRDELPEKITNRF........................................................................................................................................................................................ 179
51 -13.100[R] COG1163 Predicted GTPase  ali follow..  12  32......KAKLAKLRRELLTSASSGSGGGAGIGFDVARTGVASVGFVGFPSVGKSTLLSKLTGEAAEYEFTTLVTVPGV------------------------------------KGAKIQMLDLPGDGAKDGRGRGKQVIAVARTCNLLFIILDVNKP--LHHKQIIEKELEGVGIRLNKTPPDILIKKKEK...................................................................................................................................................................................... 187
52 -13.000[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  13  24.EYHLGQLKAKIAKLRTQLLEPPKGASGGGEGFEVTKYGHGRVALIGFPSVGKSTLLTMLTGEAASYEFTTLTCIPGV------------------------------------NDTKIQLLDLPGEGASEGKGRGRQVIAVAKSSDLVLMVLDASKSE--GHRQILTKELEAVGLRLNKTPPQIYFKKKKT...................................................................................................................................................................................... 184
53 -12.800[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  12  32.......KARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGEVAAYEFTTLTTVPGV------------------------------------KGAKIQLLDLPGEGAKDGKGRGRQVIAVARTCNLILIVLDVLKP--LGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELD....................................................................................................................................................................... 201
54 -12.700[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  10  36VEATYKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKVAFFGRTSSGKSSVINAMLDKVLPSGIGHITNCFTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVRLVLVDSPGTDVTTEL--DSWIDKFCLDADVFVLVANSESTLMNTEKHF----FHKVNEWLSKPNIFILNNRWDASASEPEYQHMERCLHFLVEELKVANALEAQNRIFFVSAKEVLSARKQK---LAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAK------QILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKIKEVTEEVA-NKVSCAMTDEIC........... 418
55 -12.600[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  11  3.......................................NQSEINIGLVG-GKTTLTKALSDTHSEETKRGISIRLGYADITFRKCPQCEAPMCYTTAEICERCGTETELLR-----KVSFVDAPGHETLMATMLSGA-----ALMDGAILVIAANEPCPQPQTKEHLMALDVIGVKD----VIVVQNKIDIVSKERALESYREIKEFVKGTCAEDAPIIPVSAQQGANIDILIETIEERI..................................................................................................................................... 197
56 -12.400[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  12  321.........................SKPGRNGLEQHFLFELKSILIGLPNAGKSTILNKI-SNAKPKIGHWQFTTLSPTIGTVSLGF---------------------------GQDVFTVADIPGQGASLDKGMGLEFLRHIERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNIL-IVCNKVDIDAEKSESFAKYLQVEKFSKSQEWDCVPI--SALREKT................................................................................................................................................. 499
57 -12.200[R] COG5258 GTPase  ali follow..  9  100................................SREEPPPTVTVVALGNVDAGKSTLVGVLTTGRLDDGKGLARSYAVLTGRTSAVSLRLLGFSGDKVVNHGLIDPLDEAEVYKRSDKLVLLVDVGGHERYLRTALRGLFS---SQPDYVMLVVAANSGVQKMTKEHLGIAVAI------GIPVFVVVTRIDITPSEVFQKTVEEVVRILKMPAGRVAPVFYVSSVTGHGL-----DLLLRFLSLLPRRRRWDYGGEFLMYISDIYLVKGVGVVIGGLVEKGILHVGDRVWL-DGKWMQTVVKSIHFNRTPVESAKAGSFITVALDKVEKVEKGMVLSARPLKAVREVTADVLVLRH.................. 441
58 -12.100[R] COG1160 Predicted GTPases  ali follow..  12  3.......................................TPVVALVGRPNVGKSTLFNRLTRTRDALVADFPGLTRDRKYGHAH------------------------------AGYDFIVIDTGGTEEGVEEKMAEQSLLAIDEADIVLFLVDARAGLTAADIG-----IANYLRQRQNKITVVVANKTDGIDADSHCAEFYQL---------GLGEIEQIAASQGRGVTQLMEQVLAPF..................................................................................................................................... 164
59 -12.000[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  15  1MDPMESSSEQDIVEESQKLVDSLDKLRVSAASSSSNFKKKP-IIVVGMAGSGKTSFLHRLVCHTFDSKSHGYVVNLDPAVMSLPFGANIDIRDTVKYKEVMKQYNVVSVIEKRADQLDYVLVDTPGQEIFTWSASGAIITEAFAS--VVTYVVDTP---SSSPITFMSNMLYACSLYKTRLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTATLANSLSLSLYEFYRNIRSVGVSAIS................................................................................................................................ 269
60 -11.500[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  10  2...............................KIMASQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEEYRKEAEQKGKATFEFAWVMDRFKEERERGVTIDLAHRKFTDKYYFTLIDAPGHRDFVKNMITGTSQ-----ADAAILVISAREGEGVMEQTREHAFLARTLGVP---QMVVAINKMDATSPPYSEKRYNEVKADAEKLLRSIGFK--ISGYKGDNVTKPSPNM-PTLLQALDAFKVPEKPINKPLRIPVEDVYSITG....................................................................................................... 242
61 -11.500[J] KOG0469 Elongation factor 2  ali follow..  13  5.........................TVDEIRALMDRKRNIRNMSVIAHVDHGKSTLTDSLVSKATRKDEQERCITIKSTAISLFFELEKKDLEFVKGENQFETVEVDGKKEKYNGFL-INLIDSPGHVDFSSEVTAA-----LRVTDGALVVVDCVSGVCVQTETVLRQAIAE------RIKPVLFMNKMDRALLELQ-LGAEELFQTFQRIVENINVIIATYGDDDGPMGPIMVDPSI....................................................................................................................................... 220
62 -11.500[R] KOG1533 Predicted GTPase  ali follow..  8  2........QMNLNEKKQLLRVRVYATSEKGENLGSTHWTMYGVLVIGAPGAGKSTFCAGLTDIFSQTKRPFLTINLDPANDTMAYAPDVNITEMITVNDVMDRLGLGPNQKIEANHKKYLIIDCPGQELYKSEGELWKVIRFLEKSGCALHLADSL---CSDPSKFISVALSTLAMVTMEMPQVNCLSKADLFSEDGTYDLEFFSH-----LPDVNRLLDLLNEVPGLEKYRKLNEAICGVISDFDLVSFVPLAVENKESMMKVI............................................................................................................. 274
63 -11.400[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali follow..  13  31...................................KKGFEFTLMVVGESGLGKSTLVNSLFERIIPDAIEKQKQTVKLEASTVEIEERGVK-------------------------LRLTVVDTPGFGDAIDNYIDEQYERFLRDIHCCFYFISPFGHGLKP--------VEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIES................................................................................................................................................................... 203
64 -11.400[M] COG0481 Membrane GTPase LepA  ali follow..  12  2.....................................KNIRNFSIIAHIDHGKSTLSDRLIQ---------TCGGLSDREMEAQVLDSMDLERERGITIKAQSVTLNYKA-KDGETYQLNFIDTPGHVDF-----SYEVSRSLAACEGALLVVDAGQGVEAQTLANCYTAIEM------NLEVVPILNKIDLPAADPE----RVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVHKIPAPEGDPNAPLQALIIDSWFDN............................................................................................................... 202
65 -11.200[K] KOG1534 Putative transcription factor FET5  ali follow..  11  6..........................................AFVCGVASSGKSTFCGALMSKSVGRSCHLVNLDPAAENFEWEPTVDIRDLISIDDVMEELDYGPNGGLIYCFEFLMENIFDMPGQIELYTPALIRHLQVTLNFRPCAVYLLESQ---LVDRTKFFAGVLSAMSMVMMEVPHINLLSKMDLLKDNNNITKAELKRFLNTDPLLLTGEINETTNPKFHELNRCIVQLIDNFLPLESGNEESVSRVLSYID.................................................................................................................. 250
66 -11.100[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  11  1.................................MGKEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAQEMGKGSFKYAWVLDKLKAERERGITIDIALWKFEAKYYITIIDAPGHRDFIKNMITGTSQ-----ADCAVLVVACGTGEFEAGISKNGQTREHALLAQT--QLIVACNKMDSTEPPFSEARFTEITNEVSGFIKKIGYNVPISGFNGDNMLEVSSNM......................................................................................................................................... 208
67 -11.100[R] COG2262 GTPases  ali follow..  15  182........................EKQREQGRQSRIKADVPTVSLVGYTNAGKSTLFNRITEARVYAADQLFA-----------------------------TLDPTLRRIDVADVGETVLADTVG---FIRHLPHDLVAAFTRQATLLLHVIDAADVRVQENIEAVNTVLEEI----HEIPTLLVMNKIDMLEDF---------EPRIDRDEENKPIRVWLSAQTGAGIPQLFQALTERLSGEVAQHTLRL.......................................................................................................................... 372
68 -10.700[J] COG0050 GTPases - translation elongation factors  ali follow..  12  2.............................SKEKFERTKPHVNVGTIGHVDHGKTTLTAAITTVLAKTYGGSARAFDQIDNAPEEKARGI-------------TINTSHVEYDTPAR-HYAHVDCPGHADYVKNMITGA-----AQMDGAILVVAATDGPMPQTREHIL-----LGRQVGVPYIIVFMNKCDMVDDEELLELVEMEVRELLSAYDFPGDDLPVVRGSALKALEGEAEWEAKIIELAGYLDSYIPEPERAIDKPFLLPIED......................................................................................................... 217
69 -10.700[R] KOG0410 Predicted GTP binding protein  ali follow..  16  272IEVDKRILRTQIGVLKKELES---RKHRKQYRSRRVAIPVPVVSLVGYTNAGKSTLLNQLTGANVLAENR-LFATL----------------------------DPTTRRVQMQNGKEFLLTDTVG---FIQKLPTTLVAAFIAESSLLVHVVDISHPLAEQQIEAVEKVMSEL----SSIPKLVVWNKVDRVDDPQKVKLEAEETGDT----------ICISALTGEGLDDFCNAVHEKLKDSMVWVEALL.......................................................................................................................... 483
70 -10.700[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  14  3...............TALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSSKRHGTQGEKLDLALLVDGLQAEREQGITIDVAYRYFSTEKR-KFIIADTPGHEQYTRNMATGA-----STCELAILLIDARKGVLDQTRRH--SFISTLLGIK---HLVVAINKMDLVSEETFTRIREDYLTFAGQLPGNLDIRF-LSALEGDNVASQSESM-PTLLEVLETVE............................................................................................................................. 236
71 -10.600[F] COG4088 Predicted nucleotide kinase  ali follow..  7  4..........................................IIVSGYPSSGKTTRSNELKKALEDRIHQNIDNTKDYRVIIIN---------------------------ESLNIEKETYRESKNEKAARGLLYSAVQRELSKST---FVICDALN------IKGFRYQLYCESKSMYAVPQDLCRKFNSNKEQPYPDDVLEQLMFRYEEPNGMTRWDSPLFTVLHDDASCPIDDIWSVLIHNKNVKPNQATMVKPPAEVNYLYELDK------------------TTQDVIMLILDNSNDTSLITVPGSKLQIALPSVTVSLPLLQRRQFIQINRQQSYNTNVLKEMFVEFLNGQFET.............. 279
72 -10.500[R] COG3911 Predicted ATPase  ali follow..  11  2...................................QNDFDRVFVLTGGPGSGKTTLIAALRRAGFATSVVAGRGIVRDQSSIGGTALPWSDRTLFAELMLSWEMRSYQNAVEQKGPV---FFDRG--------------------------VPETLGYLRLSGLPVADHVSTAAKRFRYNPRVFIAIFAQDEERKQTPDEAKCTYHALAEIYTE---LGYELVPLPLAPVETRLRFVLADA..................................................................................................................................... 180
73 -10.500[J] KOG0468 U5 snRNP-specific protein  ali follow..  11  83VQEEDAQPKKLKFQIKEQDMQETTYDMEFMADLMDTPPLIRNVALVGHLHHGKTTFVDCLIR-----QTHPQFETMEERQLRYTDTLFTEQERGCSIKATPVTLVLQDVK---QKSYLLNIFDTPGHVNFSDEATAA-----MRMSDGVVLFIDAAEGVMLNTERLLKHAVQE------RQAITVCINKIDRLILELKLPPQDAYFK....................................................................................................................................................................... 279
74 -10.400[DZ] COG5019 Septin family protein  ali follow..  15  91...................................RQGFNFNVLVLGESGSGKSTLVNTLLKSLTGDFGVNPEPTVMINSSAVEIVENGIS-------------------------LQLNVIDTPGFGDFIDNDIEGRYDQYLELVHACIFFIQPTGHAISA--------LRVMLALHEKVNIIPIIAKADTLTDDELNFTKEMILRDIQY................................................................................................................................................................... 266
75 -10.400[R] COG0486 Predicted GTPase  ali follow..  12  229.........................................KVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHI-----------------------------DGMPLHIIDTAGATDEVERIGIVRAWSEIEQADRILLMLDSTEADNQDLEKVRSEFLT---KLPSNIPVTIVRNKADLSGENEGIVEQNGYT------------VITLSAKTQQGIALLREHLKQSMGYQTNMEGGFLARRRHLEALEQA.............................................................................................................. 410
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Plewczynski D, Tkacz A, Wyrwicz LS, Godzik A, Kloczkowski A, Rychlewski L. Support-vector-machine classification of linear functional motifs in proteins. J Mol Model 2006 Aug;12(4):453-61. Epub 2005 Dec 10.