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Query: [U] KOG3887 Predicted small GTPase involved in nuclear protein import, from VFDB

Results of FFAS03 search in VFDB
Master-slave alignment(slide right to see more) does not show gaps in the query sequence, use ali links to display alignment between query and templates.
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# Score Template Links and tools%idFirst MSQVLGKPQPQDEDDAEEEEEEDELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKVVKSRKVQNRLQKKKRATPNGTPRVLLLast
1 -103.000[U] KOG3887 Predicted small GTPase involved in nuclear protein import  ali  100  1MSQVLGKPQPQDEDDAEEEEEEDELVGLADYGDGPDSSDADPDSGTEEGVLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPNETLFLESTNKICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGTPYDKESTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKVVKSRKVQNRLQKKKRATPNGTPRVLL 400
2 -67.200[T] KOG3886 GTP-binding protein  ali follow..  19  36.........................................................NTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSDNIFRNVEVLIYVFDVESREEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLS-----RPLECSCFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAEIIEADEVLLFERATFLVISHYQCKEQRHRFEKISNIIKQFKLSCSKL-----------AASFQSMEVRNSNFAAFIDIFTSN-TYVMVVVSDPSIPSAATLINIRNARKHFEKLERVDGPKQC........................ 370
3 -40.100[U] KOG0076 GTP-binding ADP-ribosylation factor-like protein yARL3  ali follow..  12  1.............................................MFHLVKGLYNNWNKKEQYSILILGLDNAGKTTFLETLKKEYSLAALEKIQPTVGQNVATIPVDSKQILKFWDVGGQESLRSM---WSEYYSLCHGIIFIVDSSDRERLDECSTTLQSVVMDEEIEGVPILMLANKQDRQDRMEVQDIKEVFNKIAEH-----ISARDSRVLPISALTGEGVKDAIEWMIVRLERNKKSRPPIYK....................................................................................................................................................... 198
4 -39.500[U] KOG0070 GTP-binding ADP-ribosylation factor Arf1  ali follow..  20  1.............................................MGLSFGKLFSRLFAKKEMRILMVGLDAAGKTTILYKL----KLGEIVTTIPTIGFNVETVEY-KNISFTVWDVGGQDKIRPL---WRHYFQNTQGLIFVVDSNDRDRVVEARDELHRMLNEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRQ-------RHWYIQSTCATSGEGLYEGLDWLSNNIASK................................................................................................................................................................ 180
5 -39.300[U] KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1  ali follow..  20  1.............................................MDGGVLSYFRGLLGSREMRILILGLDGAGKTTILYRL----QVGEVVTTIPTIGFNVEQVTY-KNLKFQVWDLGGQTSIRPY---WRCYYSNTDAIIYVVDSADRDRIGISKDELLYMLREEELAGAILVVLANKQDMDGCMTVAEVHHALGLENLKN-------RTFQIFKTSATKGEGLDQAMDWLSNTLQSR................................................................................................................................................................ 180
6 -39.000[U] KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3)  ali follow..  21  5.............................................LFKGFSKPFSRLFSNKEMRILMLGLDAAGKTTILYKL----KLNQSVVTIPTVGFNVETVTY-KNIKFNVWDVGGQDKIRPL---WRHYFTGTKGLIFVVDSADSNRISEARQELHRIISDREMRDCLLLVLANKQDLPGALSPAQITDVLQLDKLKD-------RLWNVQPTCALTGDGLLEGLAWLSQNAKLK................................................................................................................................................................ 184
7 -38.700[UZ] KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2  ali follow..  15  4.................................................LTILKKMKQKERELRLLMLGLDNAGKTTILKKF----NGEDIDTISPTLGFNIKTLEH-RGFKLNIWDVGGQKSLRSY---WRNYFESTDGLIWVVDSADRQRMQDCQRELQSLLVEERLAGATLLIFANKQDLPGALSSNAIREALELDSIRSHHWCIQG-------CSAVTGENLLPGIDWLLDDISSRIFTAD........................................................................................................................................................... 184
8 -38.400[R] KOG0074 GTP-binding ADP-ribosylation factor-like protein ARL3  ali follow..  17  1.............................................MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQL----ASEDISHITPTQGFNIKSVQS-QGFKLNVWDIGGQRKIRPY---WKNYFENTDILIYVIDSADRKRFEETGQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRD-------RVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK.............................................................................................................................................................. 182
9 -38.400[R] KOG0075 GTP-binding ADP-ribosylation factor-like protein  ali follow..  17  13......................................................KSIFWKEEMELTLVGLQFSGKTTFVNVIASGQFAEDMI---PTVGFNMRKITR-GNVTIKVWDIGGQPRFRSM---WERYCRGVNAIVYMVDAADLDKLEASRNELHSLLDKPQLAGIPVLVLGNKRDLPGALDETGLIERMNLSSIQD-------REICCYSISCKEKDNIDITLQWLIQHSKSQSR.............................................................................................................................................................. 186
10 -38.100[U] KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1  ali follow..  14  18...........................................................QKEAKILFLGLDNAGKTTLLHML----KDERLVQHQPTQHPTSEELSI-GKIKFKAFDLGGHQIARRV---WKDYYAKVDAVVYLVDAYDKERFAESKRELDALLSDEALATVPFLILGNKIDIPYAASEDELRYHLGLTNFTTTLGDSGVRPLEVFMCSIVRKMGYGEGFKWLSQYI................................................................................................................................................................... 192
11 -37.900[R] COG1100 GTPase SAR1 and related small G proteins  ali follow..  21  15..........................................................SNKELRILILGLDGAGKTTILYRL----QIGEVVTTKPTIGFNVETLSY-KNLKLNVWDLGGQTSIRPY---WRCYYADTAAVIFVVDSTDKDRMSTASKELHLMLQEEELQDAALLVFANKQDQPGALSASEVSKELNLVELKD-------RSWSIVASSAIKGEGITEGLDWLIDVIKEE................................................................................................................................................................ 181
12 -29.500[U] KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily)  ali follow..  13  51.........................................................RRTKSNTVLLSGLSGSGKTVLFYQLRDGSSHQGAV---TSMEPNEGTFVLHNVKPVHLIDVPGHSRLISKL---EEYLPRAAAVVFVVDALEFLPAASEYLYDILTNASVIKNKTPVLLCCNKTDKVTAHTKEFIRKQMEKEIDKLRVSRSAIHNKVTVAEASGLTGETDQVQEFIREHVKP................................................................................................................................................................. 260
13 -23.300[R] COG2229 Predicted GTPase  ali follow..  14  2............................................................RENKIIFTGPVGVGKTTAIAAISDEALVQTDASANTTVAMDYGAISLDEDTKVHLYGTPGQERFN---FMWEILSQGSMGLVLLLDNART--NPLKDLEFFLHSFRGLLEKAPVVVGITKMDIRSQPGIDVYHKYLAKHNLN------------VFEIDARKEDDVKQLVSAMLFSIDPGLEV............................................................................................................................................................. 178
14 -21.800[R] KOG1673 Ras GTPases  ali follow..  16  103...............................................................KISLLGDCQTGKTTFVV----KYVGDENQSFLEMTGLNDKTFYVQGTISFSIWDVGGDEKRSKDHI--PIACKDAVAILFMFDLTSR--STLNSVFGWYSQARKWNKTAIPILIGTKFDDFVRLPPNL------QWTIVTQARAYAKVMNASLFFSSA-NINVNKIFKFILARLFNLPWKIDRNLT....................................................................................................................................................... 278
15 -21.700[U] KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily  ali follow..  17  14...............................................................KLVLVGDGGTGKTTFVKRHLTGEFEKK---YIATIGVEVHPLSFYGEIKFDVWDTAGQEKFGGLR---DGYYINAQCAIIMFDVTSR--ITYKNVPNWHRDLVRVCENIPIVLCGNKVDVKERKVKAKTIT--------------HRKKNLQYYDISA-NYNFEKPFLWLARKLAGNPQL............................................................................................................................................................. 176
16 -20.600[T] KOG4252 GTP-binding protein  ali follow..  21  11...............................................................KMVVVGNGAVGKSSMIQRYCKGIFTKD---YKKTIGVDERQIQVNDEVRLMLWDTAGQEEFDAIT---KAYYRGAQACVLVFSTTDR--GSFEAVSSWREKVVAEVGDIPTVLVQNKIDLLDD-----------SCIKNEEAEALAKRLRLRFYRTSVKEDNVNEVFKYLAEKYLQKLKQ............................................................................................................................................................. 175
17 -20.200[R] KOG0079 GTP-binding protein H-ray, small G protein superfamily  ali follow..  17  12...............................................................KLLIIGDSGVGKSSLLLRFADNTFSENYI---TTIGVDIRTMDINGQVKLQIWDTAGQERFRTIT---STYYRGTHGVVVVYDVTNG--ESFGNVKRWLQEIENNCDSVQKVLVGNKCEENER-----------RVVLESDARNYAQSMNISFFETSAKEDNVEPMFTCITSLVLTAKL.............................................................................................................................................................. 175
18 -20.000[R] KOG0395 Ras-related GTPase  ali follow..  12  13.......................................................SVPAKNSYRMVVLGASRVGKSSIVSRFLNGRFEDQ---YTPTIEFHRKVYNIRGDYQLDILDTSGNHPFPAMR---RLSILTGDVFILVFSLDNRESKQILEVKSCLKNKTKEAAELPMVICGNKNDHGELCRQVP---------TTEAELLVSGDENCAYFEVSAKKNNVDEMFYVLFSMA................................................................................................................................................................... 190
19 -20.000[R] KOG0080 GTPase Rab18, small G protein superfamily  ali follow..  20  10...............................................................KILIIGESGVGKSSLLLRFTDDTFDPE---LAATIGVDVKTISVDGNAKLAIWDTAGQERFRTLT---PSYYRGAQGVILVYDVTRRDTFVKLDNWLNELETYCTRNDIVNMLVGNKIDKENREVDRNEGLKFARKHSMLFIE-----------ASAKTCDGVQCAFEELVEKIIQTPGLWES.......................................................................................................................................................... 178
20 -19.600[R] KOG0091 GTPase Rab39, small G protein superfamily  ali follow..  19  11...............................................................RLILIGDSTVGKSSLLKFFTDGKFAELS---DPTVGVDFFEMKDGTQIKLQLWDTAGQERFRSIT---KSYYRNSVGVLLVYDISNHASFEHIPLWMMEAQRHIEPHRPVFALVGCKLDLINAGGHREVTTEEAQKFAKQH--------GLHFVETSARSANVEEAFRMVTQEVYARIRS............................................................................................................................................................. 181
21 -19.600[R] COG3596 Predicted GTPase  ali follow..  12  36...........................................................HYEPVIGIMGKTGAGKSSLCNALFAGEVSPVSDVAACTRDPLRFRLQIGE-HFMTIVDLPGGVRDTEYAALYREQLPRLDLILWLIKADDRALATDEHFYRQVI---GEAYRHKMLFVISQSDKAEPTSGGNILSTEQKQNISRKICLLHELFQ-VCAVSVRLQWGLRVMAERMIKCL................................................................................................................................................................... 216
22 -19.600[R] COG1084 Predicted GTPase  ali follow..  12  156.......................................................PTVDLDAFTVVIAGFPNVGKSTLLRTL-TGAEPEVADYPFTTKGIQIGHLERKW-KRIQVIDTPGEDMNNIELQAMVALENIADVIMFIFDASETCGYTLESQYSLYLGIRSVF-DIPVVTVFNKMDLAENVKYLEEYINMVEDP---------------LKVSAFEGRGVSKIIKKLEGLYEKETREAHDNV........................................................................................................................................................ 336
23 -19.400[U] KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases  ali follow..  24  22...............................................................KLVLLGESAVGKSSLVLRFVKGQFHEFQ---ESTIGAATQTVCLDDTVKFEIWDTAGQERYHSLA---PMYYRGAQAAIVVYDITNE--ESFARAKNWVKELQRQSPNIVIALSGNKADLANK-----------RAVDFQEAQSYADDNSLLFMETSA-SMNVNEIFMAIAKKLPKNEPQ............................................................................................................................................................. 187
24 -19.400[R] KOG2486 Predicted GTPase  ali follow..  12  128......................................................EDCPADGLPEFALVGRSNVGKSSLLNSLVRR---KRLALTSKKPGKTQCINHFRINDKWYLVDLPGKQDWNKFTKDYFLNRSTLVSVFLLVDASIPVKPIDLEYASWLGQN-----QVPMTLIFTKCDKRKKKKNGGKKPEANIKEFQDLIQGFFETTPPWIMTSSVTNQGRDEILLHMAQLR................................................................................................................................................................... 312
25 -19.400[R] KOG0394 Ras-related GTPase  ali follow..  16  10...............................................................KVIILGDSGVGKTSLMNQYVNKKFSNQ---YKATIGADTKEVQFEDRFTLQIWDTAGQERFQSLG---VAFYRGADCCVLVYDVNSMKSFENLN-EFLIQASPSDPENFPFVLIGNKVDVDDGNSRVVSEKKAKAWCASK---------NIPYFETSAKVGNVEEAFQCIAKDALKSGE.............................................................................................................................................................. 181
26 -19.100[U] KOG0093 GTPase Rab3, small G protein superfamily  ali follow..  17  24...............................................................KILIIGNSSVGKTSFLFRYADDSFTPAFV---STVGIDVKTIYRNDKIKLQIWDTAGQERYRTIT---TAYYRGAMGFILMYDITNE--ESFNAVQDWSTQIKTYWDNAQVLLVGNKCDMEDE-----------RVVSSERGRQLADHLGFEFFEASAKDNNVKQTFERLVDVICEKMS.............................................................................................................................................................. 188
27 -19.000[U] KOG0095 GTPase Rab30, small G protein superfamily  ali follow..  20  11...............................................................KIVLIGNAGVGKTCLVRRFTQGLFPPGQ---GATIGVGIKTVEINGEVKLQIWDTAGQERFRSIT---QSYYRSANALILTYDITCE--ESFRCLPEWLREIEQYASNKVITVLVNKIDLAER-----------REVSQQRAEEFSEAQDMYYLETSAKESNVEKLFLDLACRLISEARQ............................................................................................................................................................. 176
28 -19.000[TU] KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins  ali follow..  21  10...............................................................KLLLIGDSGVGKSCLLLRFADDSYLDSYI---STIGVDIRTVEQDGKIKLQIWDTAGQERFRTIT---SSYYRGAHGIIVTYDVTDL--ESFNNVKQWLNEIDRYSENVNKLLVGNKCDLTSQ-----------KVVSTETAKAFADELGIPFLETSAKNANVEEAFMAMTAAIKTRMAS............................................................................................................................................................. 175
29 -19.000[TU] KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins  ali follow..  17  11...............................................................KLLLIGDSGVGKSCLLLRFSEDSFTPSFI---TTIGIDIRTIELDGKIKLQIWDTAGQERFRTIT---TAYYRGAMGILLLYDVTDK--KSFDNVRTWFSNVEQHSENVYKILIGNKCDCEDQ-----------RQVSFEQGQALADELGVKFLEASAKTNNVDEAFFTLAREIKKQKI.............................................................................................................................................................. 175
30 -19.000[R] KOG0088 GTPase Rab21, small G protein superfamily  ali follow..  20  14...............................................................KIVLLGEGCVGKSSLVLRFVENKFSCKH---LSTIQASNKTVNVEDCADLHIWDTAGQEKYHALG---PIYYRGSNGVLLVFDITDR--KSFEKVKNWVLEIKTCGNTAEILIVGNKIDLEEE-----------RQVTRQDAEAYAESEGALYMETSA-NVGISDAFESLTAKMIEHSRT............................................................................................................................................................. 179
31 -18.900[U] KOG0081 GTPase Rab27, small G protein superfamily  ali follow..  16  11...............................................................KFLALGDSGVGKTSVLYQYTDGKFNSK---FITTVGIDEKRVVYRASIHLQLWDTAGQERFRSLT---TAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQ-----------RVVKEEEAIALAEKYGIPYFETSA-GTNISQAIEMLLDLIMKRME.............................................................................................................................................................. 186
32 -18.700[U] KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily  ali follow..  16  11...............................................................KLVFLGDQSVGKTSIITRFMYDKFDTT---YQATIGIDSKTMYLEDTVRLQLWDTAGQERFRSLI---PSYIRDSSVAVVVYDVANR--LSFLNTSKWIEEVRNERAGDVIIVLVNKTDLVEK-----------RQVSIEEGDSKGREYGVMFIETSA-GFNIKPLFRKIAAALPGMESY............................................................................................................................................................. 176
33 -18.700[U] KOG0086 GTPase Rab4, small G protein superfamily  ali follow..  21  10...............................................................KFLVIGSAGTGKSCLLHQFIENKFKQDS---NHTIGVESRVVNVGGKVKLQIWDTAGQERFRSVT---RSYYRGAAGALLVYDITSR--ETYNSLAAWLTDARTLSPNIVVILCGNKKDLDPE-----------REVTFLEASRFAQENELMFLETSALTENVEEAFLKCARTILNKIDS............................................................................................................................................................. 175
34 -18.600[U] KOG0097 GTPase Rab14, small G protein superfamily  ali follow..  19  13...............................................................KYIIIGDMGVGKSCLLHQFTEKKFMADC---PHTIGVETRIIEVSGQIKLQIWDTAGQERFRAVT---RSYYRGAAGALMVYDITRR--STYNHLSSWLTDARNLNPNTVIILIGNKADLEAQ-----------RDVTYEEAKQFAEENGLLFLEASAKTENVEDAFLEAAKKIYQNIQD............................................................................................................................................................. 178
35 -18.500[U] KOG0098 GTPase Rab2, small G protein superfamily  ali follow..  19  8...............................................................KYIIIGDTGVGKSCLLLQFTDKRFQPVH---DLTIGVEARMVTIDGKIKLQIWDTAGQESFRSIT---RSYYRGAAGALLVYDITRR--DTFNHLTSWLEDARQHNSNMVIMLIGNKSDLEAR-----------REVKREEGEAFAREHGLVFMETSAKTANVEEAFIDTAKEIYRKIQE............................................................................................................................................................. 173
36 -18.500[U] KOG0087 GTPase Rab11/YPT3, small G protein superfamily  ali follow..  21  12...............................................................KTVLIGDSGVGKSNLLMRFTRNEFNIES---KSTIGVETRNIVLDNKIKAQIWDTAGQERYRAIT---SAYYRGAVGALIVYDITKQ--SSFDNVGRWLKELREHDSNIVIMLVGNKTDLLHL-----------RAVSTEEAQAFAAENNLSFIETSAMDANVEEAFQTVLTEIFRIVSN............................................................................................................................................................. 177
37 -17.800[R] KOG0083 GTPase Rab26/Rab37, small G protein superfamily  ali follow..  18  470...............................................................KVIMLGDSGVGKTSLLIRFRDGR---VPSYFLSTVGIDNKVVVVDGTVKLQIWDTAGQERFRSVT---HAYYRDAHALLLLYDVTNK--TTYDNIRAWLGEIREYAQEDVVIVLINKADCSGSE----------RQVKREDGERLGREHNVPFMETSA-GLNVELSFTAVARQLKSR................................................................................................................................................................ 634
38 -17.100[R] KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily)  ali follow..  13  162.......................................................PSIDPNTRTVLICGYPNVGKSSFMNKV-TRADVDVQPYAFTTKSLFVGHTDY-KYLRYQVIDTPGFEDRNIIEMCSITALAHLRAVLFFLDISGSCGYTIAQQAALFHSIKSLFMNKPLVIVCNKTDLMPMENISEEDRKLIEEMKSEAMKTAMGASE-LLKMSTLTDEGVMSVKNAACERLLDQ................................................................................................................................................................ 352
39 -16.700[R] COG0218 Predicted GTPase  ali follow..  13  18......................................................SHYPQDELPEIALAGRSNVGKSSFINTMLNR---KNLARTSGKPGKTQLLNFFNIDDKMRFVDVPGYGCMIEEYLTTR---ENLRAVVSLVDLRHDPSADDVQMYEFLKYY-----EIPVIIVATKADKIPRGKWNKHESAIKKKLN-------FDPSDDFILFSSVSKAGMDEAWDAILEKL................................................................................................................................................................... 195
40 -15.900[E] COG4917 Ethanolamine utilization protein  ali follow..  15  2..............................................................KRIAFVGSVGAGKTTLFNALQGN-------------YTLARKTQAVEFNDKGDIDTPGEYFNHPRWYHA-TTLQDVDMLIYVHGANDPESRLPAGLLDIGV-------SKRQIAVISKTDMPDADVAATRKLLLETGFEEPM-----------FELNSHDPQSVQQLVDYLASLT................................................................................................................................................................... 146
41 -15.800[R] KOG0393 Ras-related small GTPase, Rho type  ali follow..  14  2............................................................QAIKCVVVGDGAVGKTCLLLSYTTNAFPGEYI---LTVTYSTNVMVDGRPINLSLWDTAGQDDYDQFR---HLSFPQTDVFLVCFALNNPASFENVR-AKWYPEVSHHCPNTPIILVGTKADLREDRDTIERLRESRLQVSHTQGYVMAKEIKAVKYLSALTQIGLKQVFDEAIRTGLTPPQTPQT.......................................................................................................................................................... 185
42 -15.700[V] KOG1707 Predicted Ras related/Rac-GTP binding protein  ali follow..  11  1................................................MWMGVGDSSGSPKPIRIVVVGEKGSGKSSLIMAAARNTFHPNIPSLLPYTNLPSE---FPDRIPATVIDTSSRPEDKGKVVKE---VRQADAIVLTFAFDRPETLDRLS-KYWLPLFRQLEVRVPIIVAGYEVDNKEAYNHFSIEQITSALMKQ------YREVETSIQWSAQRLDQAKDVLYYAQKAVIPVGPVFDQENNVLKPRCIAALKRIF......................................................................................................................................... 204
43 -14.300[T] KOG1486 GTP-binding protein DRG2 (ODN superfamily)  ali follow..  9  56.......................................................EVTKYGHGRVALIGFPSVGKSTLLTMLTGEAASYEFTTLTCIPGV----IHYND-TKIQLLDLPGASEGKGRGRQVIAVAKSSDLVLMVLDASKSEGHRQILTKELEAVGLRLNKTPPQ-IYFKKKKT-----------GISFNTTAPLTHIDEKLCYQILHEYKIHNAEVLFRENATVDDFIDVIEGNRKYIKCVYVYNKIDVVRLSRQPNSIVISCNLKLNLDRLLARMWDEMGLVRVYSKPQGQQPDFDEPFVLSSDRGGCTVEDFCNHVHRTLVKDMKYALVWGTSTRHNPQNCGLSQHLEDEDVVQIVKKKERDEGGRGRFKSHSNAPARIADREKKAPL 397
44 -13.900[R] COG1163 Predicted GTPase  ali follow..  9  60........................................................VARTGVASVGFVGFPSVGKSTLLSKL-TGTESEAAEYEFTTLVTVPGVIRYKG-AKIQMLDLPGAKDGRGRGKQVIAVARTCNLLFIILDVNKPL-HHKQIIEKELEGVGIRLNKTPPDILIKKKEKGGISITNTVPL---THLGNDEIRAVMSEYRINSAEIAFRCDATVDDLIDVLEASSRRYMPAIYVLNKIDSLSIEELELLYRIPNAVPISSGQDWNLDELLQVMWDRLNLVRIYTKPKGQIPDFTDPVVLRSDRCS--VKDFCNQIHKSLVDDFRNALVYGSSVKHQPQYVGLSHILEDEDVVTILK............................... 368
45 -13.100[T] KOG1487 GTP-binding protein DRG1 (ODN superfamily)  ali follow..  12  1MSSTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTARIGFVGFPSVGKSTLLSNLAGEVAAYEFTTLTTVPG-----VIRYKGAKIQLLDLPGAKDGKGRGRQVIAVARTCNLILIVLDVLKPL-GHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQ---SELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIY-VLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTT--VEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQI................................. 364
46 -12.800[R] COG1159 GTPase  ali follow..  12  11................................................................IAIVGRPNVGKSTLLNKLLGQKIS--TSRKAQTTRHRIVGIHTEGPYQAIYVDTPGLHMEEKRAINRSSSIGDVELVIFVVEGTRWTPDDEMVLNKL------RDGKAPVILAVNKVDNVQEKVDLLPHLQFLASQMNFLD---------IVPISAETGMNVDTIAGIVRKHLFPEDYITDRSQRFMASEIIREKLM........................................................................................................................................... 203
47 -12.300[O] KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis  ali follow..  10  72..........................................................SRRHMKVAFFGRTSSGKSSVINAMLDKVLPSGIGHITNCF--MDKDLKAGCLVRLVLVDSPGTDVTTELDSWIDKFCLDADVFVLVANSESTLMNTEKHF---FHKVNEWLSKPNIFILNNRWDASASEPEYQHMERCLHFLVEELKVANALEAQNRIFFVSAKESARKQKAQGMPESGVALAEGFHARLQEFQNFEQIFEECISQSAVKTKFEQHTIRAK----QILATVKNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLLTLDVKKKI................................................................ 398
48 -12.000[T] KOG0099 G protein subunit Galphas, small G protein superfamily  ali follow..  22  33......................................................DKQVYRATHRLLLLGAGESGKSTIVKAARSNSSDQDLLRCRLTSGIFETKFQV-DKVNFHMFDVGGQRDERRKWI---QCFNDVTAIIFVVASSSREDNQTNRLQEALNLFKSI-RTISVILFLNKQDLLAEKVLTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDENIRRVFNDCRDIIQRM................................................................................................................................................................ 386
49 -12.000[R] COG3911 Predicted ATPase  ali follow..  9  1........................................................MQNDFDRVFVLTGGPGSGKTTLIAALRRASVVAGRGIVRDQSSIGGTALPWSDRTLFA------ELMLSWEMRSYQNAVEQKGPVFFVPETLGYLRLSGLPVADHVSTAAKRFRYNPRVFIAPPWPDIFAQDEERKQTPDEAKCTYHALAEIYTELGYEL--VPLPLAPVETRLRFVLADA................................................................................................................................................................... 180
50 -11.900[R] KOG1533 Predicted GTPase  ali follow..  16  36................................................................VLVIGAPGAGKSTFCAGLTDIFSQTKTINLDPANDITVNDVMDRLGLKYLIIDCPGQLELYKSEGELWKVIRFLECALHLADSLYCSDPSKFISVALSTLATMVTMEMPQVNCLSKADLFSEDGTYDLEFFSHLPDVNRLLDLLNEVPG----------LEKYRKLNEAICGVISDFDLVSFVPLAVENKESMMKVI........................................................................................................................................... 274
51 -11.800[R] KOG1489 Predicted GTP-binding protein (ODN superfamily)  ali follow..  17  335.............................................................ELKSILIGLPNAGKSTILNKI-SNAKPKIGHWQFTTLSPTIGTVSLFGQDVFTVADIPGIIQGASLDKGMGLEFERSNGWVFVLDLSNKNPLNDLQLLIEEVGTLEKVKTKNILIVCNKVDIDAEKSESFAKYLQVEKFSKS..................................................................................................................................................................................................... 484
52 -11.600[K] KOG1534 Putative transcription factor FET5  ali follow..  15  6................................................................AFVCGVASSGKSTFCGALMSYMKSVGLVNLDPAAEISIDDVMEELDYDYLIFDMPGQIELYTHVPILPALIRHLQCAVYLLESQFLVDRTKFFAGVLSAMSAMVMMEVPHINLLSKMDLLKDNNNITKAELKRHELNRCIVQLIDDFNMVNFLPLESGNEESVSRVLSYIDDAT.................................................................................................................................................................. 253
53 -11.500[R] COG1160 Predicted GTPases  ali follow..  11  211.........................................................EQDKNIKIAIVGRPNVGKSTLTNRILGE----DRVVVFDMPGTTRDSIYIPDGQQYTLIDTAGVRKRGKVHLAVEKFIQDANVVLLTIDARENISDQDLSLLGFILNAGR-----SLVIVVNKWDGLDQDVKDRVKSELDRRLDF--------DFARVHFISALHGSGVGNLFDSIKEAYACATQKMTTLLTRILQMA................................................................................................................................................. 404
54 -11.400[T] KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily  ali follow..  15  32......................................................DKRDARRELKLLLLGTGESGKSTFIKQM-LGYLPTQQDVLRPTTGIIEYPFDL-ENIIFRMVDVGGQRSERRKWI---HCFENVTSIMFLVALSEVESDNENRMEESKALFRTI-QNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQREPQAAREFILHFTCATDTENIRFVFAAVKDTILQL................................................................................................................................................................ 351
55 -11.300[DZU] KOG2655 Septin family protein (P-loop GTPase)  ali follow..  17  37...............................................................TLMVVGESGLGKSTLVNSLFERIIPDAIEKQKQTVKLEASTVEIEERLRLTVVDTPGDEQYERFLRDESGL-NRIHCCFYFISPFGHGLKPLD-----VEFMKKLHSKVNIVPVIAKADCLTKKEILRLKCRIMQEIESH..................................................................................................................................................................................................... 204
56 -11.300[DT] KOG0082 G-protein alpha subunit (small G protein superfamily)  ali follow..  19  26......................................................DAERDARTVKLLLLGAGESGKSTIVKVIYSNTNEQDVLHSRKTTGIIETQFSFKD-LHFRMFDVGGQRSERKKWI---HCFEGVTCIIFCAALSAVEDEEVNRMHESLHLFNSI-STTSIVLFLNKKDIFQEKVTKEDAGNYIKNQFLDLNLKKEDKEIYSHMTCATDTQNVKFVFDAVTDIIIKE................................................................................................................................................................ 346
57 -11.200[F] COG4088 Predicted nucleotide kinase  ali follow..  6  4................................................................IIVSGYPSSGKTTRSNELKKALEDRQNIDNTKDYRVIIINDESLNIEKETYRESKNEKAARGLLYSAVQRELSKSTFV-ICDALNYIKGFRYQLYCESKSM-----AVPQDLCRKFNSNKEQPYPDDVLEQLMFRYEEPNGMTRWDSPLF-----TVLHDDASCPIDDIWSVLIHNKNVKPNQATMVKPPAEVNYLYELDKTTQDVIML----------------------------LDNSNDTSLITVPGSKLQIALPSVTVSLPLLQRRRQFIQINRQQSYNTNVLKEMFVEFLNGQFET.................................. 279
58 -11.200[S] KOG4273 Uncharacterized conserved protein  ali follow..  16  2...........................................................ESRPGVLVVGSSGVGKRTLLSRLLSVEFEDSS---ESSSQTEVHGWTINTTADVSVCISHICDEYS---LPNLPNSHPLVALVMVFDLSEL--STLVALQDWVSHTDINSFDILLCI--NKVDRVPHHLAHDEYRRRLLKASDPSRDLYSDIDDFGISETE.................................................................................................................................................................................... 156
59 -11.100[L] KOG1532 GTPase XAB1, interacts with DNA repair protein XPA  ali follow..  12  2......................DPMESSSEQDIVEESQKLVDSLDKLRVSAASSSSNFKKKPIIIIVVGMAGSGKTSFLHRLVCHTFDSKVVNLDPAVMVKYKEVKRADQLDYVLVDTPGQIEIFTWSASGAIITEAFAVVTYVVDTPRSSSPITFMSNMLYACSILYKTRLPLVLAFNKTDVADHKFALEWMEDFEVFQAAIQSDNSYTATLANSLSLSL--YEFYRNIRSVGVSAISGMDGFFKAIEASAEEYMETYKADLDMRKADKERLEEERKKHEMEKLRKDM............................................................................................................... 321
60 -11.000[F] COG1618 Predicted nucleotide kinase  ali follow..  14  6.........................................................KEKTMLRIAVTGSPGVGKSTVVAKTAEKLAEKPGFKIG----RTAEIRKEGHREGFSIRDLATGKTGI-ERIGANAVRNALACDLVVIDEIGPMELISQSFVSAVEEVLE--SDKPVLAVLHHSSRVDKGNRDELPEKITNRFLRKL.................................................................................................................................................................................................... 183
61 -10.900[TU] KOG1954 Endocytosis/signaling protein EHD1  ali follow..  14  90...........................................................DAKPMILLVGQYSTGKTTFIRYLLESDFPGIRIGPEPTTDFQCSTLPNQVLESVTIVDTPGILSGEKQRIDRGYDFTGVDRIILLFDAHKLDISDEFKRCIEALAGNED----KIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYLGSFWDHLHYDLNRRLFQDEQHDLFQDLQALPR.......................................................................................................................................................... 321
62 -10.600[J] KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  14  34......................................................EVISRQATINIGTIGHVAHGKSTVVKAI-NELERNITIKLG-RSCGSSMPDEFPTDIHVSFVDCPGHDILMATMLN-----AVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLK---HILILQNKIDLVKERQAKEQYEQILAFVQGTVAEGA------IIPISAQLKYNIEVVCEYIVKKI................................................................................................................................................................... 243
63 -10.500[J] COG5256 Translation elongation factor EF-1alpha (GTPase)  ali follow..  14  6.........................................................SQKPHLNLITIGHVDHGKSTLVGRLLYEHGEIPAHIIEETIDLAHRKFE-TDKYYFTLIDAPGHRDFVKNMIT-----SQADAAILVISAREGEGVMEQTREHAFLART------QMVVAINKMDATSPPYSEKRYNEVKADAEKLLRSIGFKDISFV--ISGYKGDNVTKPSPNM-PTLLQALDAFK........................................................................................................................................................... 220
64 -10.400[J] KOG0052 Translation elongation factor EF-1 alpha/Tu  ali follow..  17  3.........................................................KEKVHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKTIDIALWKFE-TAKYYITIIDAPGHRDFIKNMIT-----SQADCAVLVVACGTGEFEAQTREHALLAQTLGVK---QLIVACNKMDSTEPPFSEARFTEITNEVSGFIKKIGYNPKAVPF-ISGFNGDNMLEVSSNM....................................................................................................................................................................... 208
65 -10.400[H] COG3172 Predicted ATPase/kinase involved in NAD metabolism  ali follow..  11  1......................................................TEVKPFFVRTVAILGGESSGKSTLVNKLANIFN------TTSAWEYGRDYVFSHLGGDEIALQYSDYDKIALGHAQYIDFAVKYANKVAFIDTDFVTTQAFCKKYHPFVQALIDEYRFDLVILLEVADGLRSLGSSVDRKEFQNLLVEMLEENNIE--------VRVEEEDYDSRFLRCVELV................................................................................................................................................................... 179
66 -10.300[J] COG0050 GTPases - translation elongation factors  ali follow..  13  1....................................................MSKEKFERTKPHVNVIGHVDHGKTTLTAAITTVLAAPEEKARGITINTSHVEYDTPAR-HYAHVDCPGHADYVKNMIT-----AQMDGAILVVAATDGPMPQTREHILLGRQV-------YIIVFMNKCDMVDDE---ELLELVEMEVRELLSAYDFPGDDLPVVRGSALKA--LEGEAEWEAKIIELAGYLDSYIP--EPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIVKVGEEVEIVGIKDTVKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREDI--VLAKPGSIKPHTTFESEVYILSKD..................................... 315
67 -10.300[R] COG2262 GTPases  ali follow..  15  189.....................................................RQSRIKADVPTVSLVGYTNAGKSTLFNRITEARVYAA--QLFATLDPTLRRIDVADVGETVLADTVGPHDLVAAFKATLQETRQATLLLHVIDAADVRVQENIEAVNTVLEEIDAHEIPTLLVM-NKIDMLEDFEPRIDRDEENKP---------------RVWLSAQTGAGIPQLFQALTERLSGEVAQHTLRL........................................................................................................................................................ 372
68 -10.300[M] COG0481 Membrane GTPase LepA  ali follow..  12  2...........................................................KNIRNFSIIAHIDHGKSTLSDRLIQEAQVLDSMDLE-TIKAQSVTLNYKATYQLNFIDTPGHVDF-----EVSRSLAACEGALLVVDAGQ------VEAQTLANCYTAIEMNLEVVPILNKIDLPAAD----------ERVAEEIEDIVGIDAMEAVRCSAKTGVGIEDVLEEIVHKIPAPEGDPNAPLQALIIDSWFDNVSLVRIKNGTLRKGDKIKVMSTGQSYNVDRLGIFTPKQVDTTILNCGEVGWVVCAIKDILGAPVGDTLTSHNNPASSVLPGFKKVKPQVYAGLFSDDYEAFRDALGKLSLNDASLFYEPENSTALGFGFRCGFLGLLHMEI 350
69 -10.200[R] COG5258 GTPase  ali follow..  11  56..........PDEELVKALETLREMARRVGASLYILRVSEGIRGKVAEVLLRAVSREEPPPTVTVVALGNVDAGKSTLVGVLTTGFSGDKVVNHGLIDPLDEAEVYKRSDKLVLLVDVGGHERYLRTALR-----SQPDYVMLVVAANSGVQKMTKEHLGIAVAI-----GIPVFVVVTRIDITPSEVFQKTVEEVVRILKMAAKAMPAGRVAPVFYVSSVTGHGL-----DLLLRFLSLLPRRRRWDYGGEFLMYISDIYLVKGVGVVIGGL............................................................................................................................... 359
70 -10.200[DZ] COG5019 Septin family protein  ali follow..  18  87.....................................................RRCVRQGFNFNVLVLGESGSGKSTLVNTLLNRLTGDFGVNPEPTVMINSSAVEIVENLQLNVIDTPGEGRYDQYLELEKHN-PRVHACIFFIQPTGHAISAME-----LRVMLALHEKVNIIPIIAKADTLTDDELNFTKEMILRDIQYH..................................................................................................................................................................................................... 267
71 -10.200[J] COG5257 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)  ali follow..  13  1........................................................MKNQSEINIGLVGHVDHGKTTLTKAL-DTHSEETKRGISIRLGYADITFETELLRKVSFVDAPGHETLMATMLS----AALMDGAILVIAANEPCPQPQTKEHLMALDVIGVK---DVIVVQNKIDIVSKERALESYREIKEFVKGTCAEDA------IIPVSAQQGANIDILIETIEERI................................................................................................................................................................... 197
72 -10.100[P] COG2895 GTPases - Sulfate adenylate transferase subunit 1  ali follow..  17  2....................................NTALAQQIANEGGVEAWMIAQQHKSLLRFLTCGSVDDGKSTLIGRLLHDTRQIYEDQLSSTIDVAYRYFS-TEKRKFIIADTPGHEQYTRNMAT-----STCELAILLIDARKGVLDQTRRHSFISTLL-------HLVVAINKMDLV--DYSEETFTRIREDYLTFAGQLPGNLDIRFVPLSALEGDNVASQSESM-PTLLEVLETVE........................................................................................................................................................... 236
73 -10.100[P] COG0370 Fe2+ transport system protein B  ali follow..  10  2............................................................SQNTYCILGNPNTGKTSLFNAL---TGSYEYVGNWSGVTVEKKVGTLRSK-TGKLIDLPGIYDLNPISRDETVV-EKFDCMLNIVDSSQIER-------NLNLTVQLLEYGAPVVMGLNMIDVAAGRGIHLNIQNLAKKL--------------ILPVVARSGKGTEDILSTLSEKH................................................................................................................................................................... 161
74 -9.970[R] COG0486 Predicted GTPase  ali follow..  15  225...........................................................REGMKVVIAGRPNAGKSSLLNALAGREAAIVTDIAGTTRDVLREHIHIDG-MPLHIIDTAGLREATDE--RAWSEIEQADRILLMLDSTEADNQDLEKVRSEFLT--KLPSNIPVTIVRNKADLSGENEGIVEQNGYT-----------------VITLSAKTQQGIALLREHLKQSMGYQTNMEGGFLARRRHLEALEQA............................................................................................................................................ 410
75 -9.930[R] KOG0410 Predicted GTP binding protein  ali follow..  16  301.....................................................RSRRVAIPVPVVSLVGYTNAGKSTLLNQLTGANVLAE--RLFATLDPTTRRVQMQNGKEFLLTDTVGPTTLVAAFRATLEEIAESSLLVHVVDISHPLAEQQIEAVEKVMSELDVSSIPKLVVW-NKVDRVDDPQKVKLEAEETGD---------------TICISALTGEGLDDFCNAVHEKLKDSMVWVEALL........................................................................................................................................................ 483
FFAS is supported by the NIH grant R01-GM087218-01
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Selected papers from Godzik Lab
Ying Zhang, Ines Thiele, Dana Weekes, Zhanwen Li, Lukasz Jaroszewski, Krzysztof Ginalski, Ashley Deacon, John Wooley, Scott Lesley, Ian Wilson, Bernhard Palsson, Andrei Osterman, Adam Godzik. Three-Dimensional Structural View of the Central Metabolic Network of Thermotoga maritima. Science. 2009 Sep 18;325(5947):1544-9.

Mayya Sedova, Mallika Iyer, Zhanwen Li, Lukasz Jaroszewski, Kai W Post, Thomas Hrabe, Eduard Porta-Pardo, Adam Godzik Cancer3D 2.0:: interactive analysis of 3D patterns of cancer mutations in cancer subsets. Nucleic Acids Research, gky1098 2018; Published on November 8 2018.

Pawlowski K, Jaroszewski L, Bierzynski A, Godzik A. Multiple model approach--dealing with alignment ambiguities in protein modeling. Pac Symp Biocomput. 1997;:328-39.